Don't forget that the stiffed his bail donors, reneging on his promise to stand trial, and thus the bail was confiscated. Supposedly, some of the donors are really pissed of, and have the means to aggressively pursue repayment (including, for example, the option to put a lien on the proceeds of any future book deals, etc. he might be offered). With interest, his debt is now to the tune of several million pounds. As soon as the first civil suit in this matter hits the courts, he will most likely have to surrender his passport because he certainly is a flight risk. I expect that will happen in the next days.
The device used to get to this type of pressure is called a diamond anvil press/cell (see wikipedia) And no, there is no way to use such a device outside a very specialized lab.
Perfect solid mixing is practically impossible with non-professional equipment. It starts with requiring all grains to be far smaller than the lethal dose, and no accumulation in layers, nooks of the apparatus, etc. Liquid mixing is better, but also more complicated on second sight - i.e. you should use a clean room to exclude dust particles which could selectively adsorb the active substance in lethal concentration, and then end up in the pill. Not exactly the type of set-up you would expect in a backyard operation.
Please understand what a patent protection provides, and what not.
A patent only prevents the commercial exploitation of the protected patent topic by competitors. It explicitly does *not* prevent *anybody* from studying and researching the patent matter, even with the explicit aim to circumvent the patent, to understand the issue beyond what is disclosed in the patent, or the commercialization of development results designed to avoid the patent matter.
For decades, Pallas, Juno, Vesta, Ceres, Astraea, Hebe, Iris, Flora, Metis, Hygiea, Parthenope, Victoria, Egeria, Irene and Eunomia were officially classified as planets. Until a new planet definition was widely accepted in 1854. And once more, the book authors were not part of the process. Therefore, this needs to be rewound, and the planetary status voted publicly upon on Facebook!
In Europe, about a dozen advanced sunscreen compounds (which avoid many of the shortcomings and dangers of older substances) are approved which are not yet (after more than 10 years of delays) FDA-certified.
The Ramazzini Institute has been publishing dubious studies for more than a decade. They have been accused of data fabrication and deliberate misinterpretation of their own source data (which they tend to keep under wraps even to government institutions) on multiple occasions, and most often publish on environmental and health topics which already got a lot of press (glyphosate, aspartam, methanol, now cell tower radiation). EPA, its Euro equivalent and other reputable institutions have more or less ceased taking these studies seriously (and not just since the new administration took office) and are actively reviewing and updating their older reports which referenced data from that source: http://www.epaarchive.cc/node/92139.html
Given this history, I am really skeptical wrt this new study.
As far as complexity of drug-like molecules is concerned, Psilocybin is really a trivial molecule where large-scale manufacturing in mushrooms or GM-yeast/bacteria would be waste of money. The paper identifies the reaction sequence and the involved enzymes, which is certainly interesting, but as absolutely ZERO applicability to any type of medical-grade commercial production.
The random generator passed only 9 of 15 standard randomness tests of NIST. Not surprising - it is unlikely that the two inverter branches are identical to the atom level, and that is a prerequisite that the thermal noise has exactly equal chance of flipping either branch.
Was not even mentioned in the summary. You can run multiple cabins in the same shaft, saving precious floor space (and move the cabins horizontally if they need to pass each other, or you can just assign up and down shafts). Thus, for larger buildings this type of elevator can actually be a major cost saver.
The average cost to develop a new drug, advance it through all clinical trials and bring it to market in the US, Europe and Japan is currently about 2 billion USD. 3 billion of donated funds are *nowhere* near the investment needed to make a sizable impression on the pharma landscape.
would you even consider to throw these into normal trash. Here in Germany, that would get you fined - (almost) empty laser printer cartridges are nearly on the same level of nastiness as old engine oil.
On the other hand, if you do not find a commercial recycling program you like (every toner manufacturer and seller on the German market has to take back its empty cartridges at zero cost, and of course we also have companies which specialize in refills and pay a few dimes for used cartridges), every communal recycling center accepts toner cartridges free of charge. And in case they'd manage to make some bucks of them, it goes into the city budget. No need for charity shopping.
First, so far this is just an idea. Zero development of the detection chemistry has been performed. But hey, at least they have already decided on their indicator color scheme!
Second, the concept requires that the antibodies, coloring agents and supporting chemicals come into direct bodily contact with (mucous) skin. That is very different from normal medicinal tests where you scrape off or otherwise obtain test material and then add additional chemicals far away from your body in a test tube. The FDA will look very, very closely at this and require lots of tests before it would grant approval. Lots of enormously expensive tests, far beyond what a novelty condom could ever earn.
while there is right now a really promising result from Biogen, in clinical trials on humans:
http://www.cnbc.com/id/102521170
THAT is news. Not some un-vetted academic work, interesting as it might be, which will need at least 10 more years of experimentation before human trials, if this approach does not die before (at least 98% probability, but of course I wish the researchers luck).
I think Slashdot needs more expertise in selecting science stories.
Yes, it is mildly interesting. But professionals do not even agree whether it is a significant new tech at all. And if is is, it is most certainly not for production of compounds in measurable quantity (e.g. more than a few mg at most). The only agreement is that the researcher is known for good marketing and a big ego.
Here are links to interesting discussions by people who actually know what they are posting about:
In US jury trials, there are almost never any jurors really knowledgeable about the topic of the trial, if the topic is of any complexity. These candidate experts are reliably weeded by by peremptory challenges during the jury selection by the side with the weaker arguments.
This is a perennial problem with US patent trials with regular international repercussions: Every other civilized nation lets expert judges decide these trials, the US uses farmer jurors from certain Eastern Texas districts who are quick to slap foreign, un-American companies with ridiculous judgements.
and once more the US system is incompatible...
on
The Magic of Pallets
·
· Score: 1
with what the rest of the world uses, because they insist on custom non-metric sizes. Just like paper. There are many more Euro pallets in use than US-sized ones.
http://en.wikipedia.org/wiki/EUR-pallet
Though in this case, the US size may actually win in the long term, because standard containers are designed to accomodate US pallets optimally. The Euro variant does not fit as well. There is a slightly wider Euro container variant designed to play nicely with Euro pallets, but with ever increasing ocean-crossing container shipping, these are on the way out.
One problem of the smallest variant of the US pallet (35 × 45.5 inch Milspec, 40 × 48 standard type) is that is does not fit trough standard European doors (which are 850 mm - Euro pallets are 800 mm, US mil pallets are 889 mm on the smallest side, standard type even larger).
That is an obvious concern, but also one the examining scientists and their reviewers had... consensus seems to be that these concerns were properly addressed, at least in the later studies.
There are now over half a dozen carbon-containing meteorites where a (small) excess of L-amino acids was found, and none where the opposite enantiomer was found to be in excess. Since these meteorites where never in contact with the earth's biosphere (the samples were of course not scraped from the surface), the chance of an evolution of isolated systems into a random chiral direction is already pretty slim.
The weight of lithium is pretty irrelevant. There are no currently existing battery technologies where Li is more than 10% of the total weight of the battery, and standard battery types are significantly below that. If the active ion weight were the prime factor, there would be more interest in beryllium batteries (just 30% more weight vs. twice the charge per ion).
Most of the commercial launches want equatorial orbits, and for that you want to launch as near to the equator as possible. As far as polar orbits for research satellites are concerned there is already the Kiruna site, which is fully equipped and at a better location for monitoring polar orbits. Polar orbits for secret missions? Countries involved in this will want to launch from their own turf. And space tourism? Does not exist yet.
Slashdot Mirror
Don't forget that the stiffed his bail donors, reneging on his promise to stand trial, and thus the bail was confiscated. Supposedly, some of the donors are really pissed of, and have the means to aggressively pursue repayment (including, for example, the option to put a lien on the proceeds of any future book deals, etc. he might be offered). With interest, his debt is now to the tune of several million pounds. As soon as the first civil suit in this matter hits the courts, he will most likely have to surrender his passport because he certainly is a flight risk. I expect that will happen in the next days.
The device used to get to this type of pressure is called a diamond anvil press/cell (see wikipedia) And no, there is no way to use such a device outside a very specialized lab.
Perfect solid mixing is practically impossible with non-professional equipment. It starts with requiring all grains to be far smaller than the lethal dose, and no accumulation in layers, nooks of the apparatus, etc. Liquid mixing is better, but also more complicated on second sight - i.e. you should use a clean room to exclude dust particles which could selectively adsorb the active substance in lethal concentration, and then end up in the pill. Not exactly the type of set-up you would expect in a backyard operation.
Please understand what a patent protection provides, and what not.
A patent only prevents the commercial exploitation of the protected patent topic by competitors. It explicitly does *not* prevent *anybody* from studying and researching the patent matter, even with the explicit aim to circumvent the patent, to understand the issue beyond what is disclosed in the patent, or the commercialization of development results designed to avoid the patent matter.
For decades, Pallas, Juno, Vesta, Ceres, Astraea, Hebe, Iris, Flora, Metis, Hygiea, Parthenope, Victoria, Egeria, Irene and Eunomia were officially classified as planets. Until a new planet definition was widely accepted in 1854. And once more, the book authors were not part of the process. Therefore, this needs to be rewound, and the planetary status voted publicly upon on Facebook!
In Europe, about a dozen advanced sunscreen compounds (which avoid many of the shortcomings and dangers of older substances) are approved which are not yet (after more than 10 years of delays) FDA-certified.
https://cen.acs.org/articles/93/i20/Decade-FDA-Still-Wont-Allow.html
The Ramazzini Institute has been publishing dubious studies for more than a decade. They have been accused of data fabrication and deliberate misinterpretation of their own source data (which they tend to keep under wraps even to government institutions) on multiple occasions, and most often publish on environmental and health topics which already got a lot of press (glyphosate, aspartam, methanol, now cell tower radiation). EPA, its Euro equivalent and other reputable institutions have more or less ceased taking these studies seriously (and not just since the new administration took office) and are actively reviewing and updating their older reports which referenced data from that source: http://www.epaarchive.cc/node/92139.html
Given this history, I am really skeptical wrt this new study.
on multiple occasions, the lead broke, and they had small conductive graphite particles floating around the control panels.
As far as complexity of drug-like molecules is concerned, Psilocybin is really a trivial molecule where large-scale manufacturing in mushrooms or GM-yeast/bacteria would be waste of money. The paper identifies the reaction sequence and the involved enzymes, which is certainly interesting, but as absolutely ZERO applicability to any type of medical-grade commercial production.
The random generator passed only 9 of 15 standard randomness tests of NIST. Not surprising - it is unlikely that the two inverter branches are identical to the atom level, and that is a prerequisite that the thermal noise has exactly equal chance of flipping either branch.
Was not even mentioned in the summary. You can run multiple cabins in the same shaft, saving precious floor space (and move the cabins horizontally if they need to pass each other, or you can just assign up and down shafts). Thus, for larger buildings this type of elevator can actually be a major cost saver.
The average cost to develop a new drug, advance it through all clinical trials and bring it to market in the US, Europe and Japan is currently about 2 billion USD. 3 billion of donated funds are *nowhere* near the investment needed to make a sizable impression on the pharma landscape.
Reacting uranium with anything does not (measurably) change its decay rate. Uraninite is NO exception.
The (few) identified atoms of each new element had all specific and measured neutron counts. And they still possess half-lifes in the seconds range.
would you even consider to throw these into normal trash. Here in Germany, that would get you fined - (almost) empty laser printer cartridges are nearly on the same level of nastiness as old engine oil.
On the other hand, if you do not find a commercial recycling program you like (every toner manufacturer and seller on the German market has to take back its empty cartridges at zero cost, and of course we also have companies which specialize in refills and pay a few dimes for used cartridges), every communal recycling center accepts toner cartridges free of charge. And in case they'd manage to make some bucks of them, it goes into the city budget. No need for charity shopping.
First, so far this is just an idea. Zero development of the detection chemistry has been performed. But hey, at least they have already decided on their indicator color scheme!
Second, the concept requires that the antibodies, coloring agents and supporting chemicals come into direct bodily contact with (mucous) skin. That is very different from normal medicinal tests where you scrape off or otherwise obtain test material and then add additional chemicals far away from your body in a test tube. The FDA will look very, very closely at this and require lots of tests before it would grant approval. Lots of enormously expensive tests, far beyond what a novelty condom could ever earn.
So in summary - a creative but stupid idea.
while there is right now a really promising result from Biogen, in clinical trials on humans:
http://www.cnbc.com/id/102521170
THAT is news. Not some un-vetted academic work, interesting as it might be, which will need at least 10 more years of experimentation before human trials, if this approach does not die before (at least 98% probability, but of course I wish the researchers luck).
I think Slashdot needs more expertise in selecting science stories.
The first and crucial step was high-temperature hydrolysis with sodium hydroxide. The remaining soup is harmless enough to be dumped.
Yes, it is mildly interesting. But professionals do not even agree whether it is a significant new tech at all. And if is is, it is most certainly not for production of compounds in measurable quantity (e.g. more than a few mg at most). The only agreement is that the researcher is known for good marketing and a big ego.
Here are links to interesting discussions by people who actually know what they are posting about:
http://pipeline.corante.com/archives/2015/03/12/the_end_of_synthesis.php
http://pipeline.corante.com/archives/2015/03/13/objections_to_the_end_of_synthesis.php
In US jury trials, there are almost never any jurors really knowledgeable about the topic of the trial, if the topic is of any complexity. These candidate experts are reliably weeded by by peremptory challenges during the jury selection by the side with the weaker arguments.
This is a perennial problem with US patent trials with regular international repercussions: Every other civilized nation lets expert judges decide these trials, the US uses farmer jurors from certain Eastern Texas districts who are quick to slap foreign, un-American companies with ridiculous judgements.
with what the rest of the world uses, because they insist on custom non-metric sizes. Just like paper. There are many more Euro pallets in use than US-sized ones.
http://en.wikipedia.org/wiki/EUR-pallet
Though in this case, the US size may actually win in the long term, because standard containers are designed to accomodate US pallets optimally. The Euro variant does not fit as well. There is a slightly wider Euro container variant designed to play nicely with Euro pallets, but with ever increasing ocean-crossing container shipping, these are on the way out.
One problem of the smallest variant of the US pallet (35 × 45.5 inch Milspec, 40 × 48 standard type) is that is does not fit trough standard European doors (which are 850 mm - Euro pallets are 800 mm, US mil pallets are 889 mm on the smallest side, standard type even larger).
That is an obvious concern, but also one the examining scientists and their reviewers had... consensus seems to be that these concerns were properly addressed, at least in the later studies.
There are now over half a dozen carbon-containing meteorites where a (small) excess of L-amino acids was found, and none where the opposite enantiomer was found to be in excess. Since these meteorites where never in contact with the earth's biosphere (the samples were of course not scraped from the surface), the chance of an evolution of isolated systems into a random chiral direction is already pretty slim.
The weight of lithium is pretty irrelevant. There are no currently existing battery technologies where Li is more than 10% of the total weight of the battery, and standard battery types are significantly below that. If the active ion weight were the prime factor, there would be more interest in beryllium batteries (just 30% more weight vs. twice the charge per ion).
Most of the commercial launches want equatorial orbits, and for that you want to launch as near to the equator as possible. As far as polar orbits for research satellites are concerned there is already the Kiruna site, which is fully equipped and at a better location for monitoring polar orbits. Polar orbits for secret missions? Countries involved in this will want to launch from their own turf. And space tourism? Does not exist yet.