Designing DNA Specific Bio-Weapons
Hugh Pickens writes writes "The Atlantic reports that experts in genetics and microbiology are convinced we may be only a few years away from the development of advanced, genetic bio-weapons able to target a single human being based on their DNA. The authors paint a scenario of the development of a virus that causes only mild flu in the general population but when the virus crosses paths with cells containing a very specific DNA sequence, the sequence would act as a molecular key to unlock secondary functions that would trigger a fast-acting neuro-destructive disease that produces memory loss and, eventually, death. The requisite equipment including gene sequencers, micro-array scanners, and mass spectrometers now cost over $1 million but on eBay, it can be had for as little as $10,000. According to Ronald Kessler, the author of the 2009 book In the President's Secret Service, Navy stewards gather bedsheets, drinking glasses, and other objects the president has touched—they are later sanitized or destroyed—in an effort to keep would-be malefactors from obtaining his genetic material. However no amount of Secret Service vigilance can ever fully secure the president's DNA, because an entire genetic blueprint can now be produced from the information within just a single cell. How to protect the President? The authors propose open-sourcing the president's genetic information to a select group of security-cleared researchers who could follow in the footsteps of the computer sciences, where 'red-team exercises,' are extremely common practices so a similar testing environment could be developed for biological war games. 'Advances in biotechnology are radically changing the scientific landscape. We are entering a world where imagination is the only brake on biology,' write the authors. 'In light of this coming synbio revolution, a wider-ranging relationship between scientists and security organizations—one defined by open exchange, continual collaboration, and crowd-sourced defenses—may prove the only way to protect the president.'"
Just throwing that out there... Basic scenario; brilliant biochemist does exactly this to wreck revenge on Ireland and England for the conflict that took his family. Mild flu in males, deadly to females. Some of his best work outside Dune, btw...
IAIFARSIJDPOOTV - I Am In Fact A Reality Star; I Just Don't Play One On TV
This is just cruel. A bullet would be more humane than to cause an eventual death by progressively shutting down their body.
For every interest group when they figure out that they can target "unwanted" groups of people. And imagine what the Nazis of Germany could have done during WWII - a virus designed to kill off everyone that wasn't pure Arian.
If builders built buildings the way programmers wrote programs, then the first woodpecker would destroy civilization.
We haven't yet found a cure for cancer, or other horrible and debilitating diseases, but we've found time to research something like this?
I'm on bluesnews, right? This is an announcement for another Resident Evil game?
If I was a foreign power wanting to build a genetic weapon to specifically target the President, I would haver been collecting the DNA of all the top echelon politicians well before they came close to running their presidential campaigns. If I can think of this in 10 seconds of reading TFS (not even TFA) then I'm sure that the bad guys have already thought of it - unless you subscribe to the theory that the bad guys are always dumb.
I am Slashdot. Are you Slashdot as well?
It seems that they are already attacking our politicians with this method, since they never seem to be able to remember anything they said before they were elected.
What a horrible thing to do with advances in science. We should be working to cure the world's ills, not create new ones. And those who think that by doing such things in order to prevent them is a good idea, are sadly mistaken. You just know that the goal is destruction, not prevention, for those who create in order to protect.
Maybe, but only maybe the article is right and it would be possible to design a protein, which binds specifically to a DNA sequence motif of a single human being killing the host. Currently this is a lot of work even for a few (as in 18) bases and not solvable by standard means. The design of a protein binding specifically to any random DNA sequence ( think huuuuuugee Zinc-Finger Nucleases : http://en.wikipedia.org/wiki/Zinc_finger_nuclease ) is in my opinion still nobel prize material.
If that was actually possible, people would use it to do good (Gene therapy etc). To knock out cancerous genes, while retaining the good ones. To bind specifically to Virus RNA or to just identifiy gene segments, which are connected somehow to genetical disorders (minus the killing of course in this case).
My point is: I don't think there is enough motivation in the scientific community to develop this just to kill a political target. There are definitely less costly ways, which leave less traces.
We've found cures for many cancers. "cancer" isn't a disease, it's a family of diseases, and killing is a whole lot easier when you're less selective. By the way, this isn't research, this is spouting notions. The two are only conflated in think tanks and idiots. but I repeat myself.
We're already very aware of how viruses constantly mutate. So, how long before this one mutates such that the "switch" is always in the "ON" position, and then proceeds to wipe out most of the human population?
BRILLIANT idea. brilliant. It's these sorts of mad scientists that truly scare me.
Add to that, there's no "kill switch" if you have a problem. Anyone caught making a virus weapon needs to die by fire. Along with the ones that funded and assisted them. The whole world needs to be completely clear about this, because it's a serious danger to every living soul.
I work for the Department of Redundancy Department.
The summary is all about defending POTUS against this, but would either political party be very inconvenienced over losing their nominal figurehead? It would probably cause a temporary drop in worldwide market values but political agendas would be unchanged and it would probably provide an opportune moment to implicate an unwanted faction and clamp down further on individual freedoms.
Or at least it's highly specific as long as the virus replicates itself perfectly, even for nonessential DNA.
It's a good thing that viruses never mutate, isn't it?
Lacking <sarcasm> tags,
Now that sounds like a good idea. Brilliant. Given the fact that we know exactly how DNA, the human body and related things work, this can only end well.
And don't think they won't do it just because I'm being a cynical old so-and-so.
Reminds me of the FOXDIE virus from the original Metal Gear Solid game.
I feel relieved that, knowing that moderate funds and a scientific background are now sufficient to create a disease that could kill billions, or target entire ethnicities for genocide, at least the president is safe.
DNA-tailored bio-weapons would give a whole new meaning to the word "genocide". Sure they'd make for a good assassination tool, but wouldn't the same DNA watermarking technques apply when dealing with groups of genetically related individuals? While current genetic theories rule out race-specific weapons of mass destruction that don't suffer from huge collateral damage, they could be used effectively to settle scores between Mafia-style crime families.
Damnit, this technology is the entire conceit behind my comic Genocide Man, but it's not supposed to exist until the year 2030 or so. The 21st century is consistently being more lethal than even I predicted.
Genocide Man -- Life is funny. Death is funnier. Mass murder can be hilarious.
Hmm, the circles keep getting smaller, like the previous SARS that only killed Chinese, the swine flu from a few years ago, that only killed Mexicans and the current wave of SARS that is only killing Qatari Arabs.
Excuse me, but please get off my Pennisetum Clandestinum, eh!
and don't get pulled over for anything.
I wonder how big is the DNA content in a breathalyzer test?
Americans sure are obsessed with their president.
Knowledge is power; knowledge shared is power lost.
I thought this was troll, too, but as pointed out here it's very much relevant.
FOXDIE is an engineered retrovirus developed by the DIA for the Pentagon. It is programmed to kill specific people by identifying the person's DNA and their nanomachines then causing cardiac arrest. The only known host for FOXDIE was Solid Snake.
your thin skin doesn't make me a troll
They create something that disables guns, eventually being able to create the device which can disable "DNA". thus creating the perfect assassination machine.
Its quite amazing how science fiction is becoming true.
My Aurora : http://www.youtube.com/watch?v=o91ZsGwJYyg
FB : https://www.facebook.com/TanveersPhotography
Navy stewards gather bedsheets, drinking glasses, and other objects the president has touched-they are later sanitized or destroyed-in an effort to keep would-be malefactors from obtaining his genetic material.
Was this policy introduced towards the end of the Clinton Administration..?
What could possibly go wrong?
"Navy stewards gather bedsheets, drinking glasses, and other objects the president has touched—they are later sanitized or destroyed—in an effort to keep would-be malefactors from obtaining his genetic material."
All it takes is one ML-1 Monica surveillance drone!
Ezekiel 23:20
But in fact the particular warm body currently occupying the office of President is not a single point of failure. He is an easily replaceable politician whose life is of no more value than yours or mine. It amazed me, the turn the story took into this silly business of protecting His Highness.
Those who would give up essential liberty to purchase a little temporary safety, deserve neither liberty nor safety.
And just how effective is this methodology when the candidate changes completely every 5 minutes?
Just like the weapon Ana Khouri uses to assassinate Taraschi in Revelation Space by Alastair Reynolds
Sci-fi has been talking about this exact type of thing for at least 20 years, so it's not a new idea.
Second, and far more important, only a complete F-N moron would even try to release such a thing.
The reason is very simple, it's called MUTATION. Yes, viruses mutate, even the engineered ones. That targeting mechanism is either going to cease to function, get bypassed, or widen it's range of targets, and there is no way to predict which it will do or when it will happen.
Here's another thing to think about. Without including a massive amount of targeting info in the virus, you won't be able to discern between related targets or just random individuals with similar dna. Because of that, you will be unintentionally targeting unwanted subjects. If that's not bad enough, if you really do put in enough info for the virus to target 1 individual in the human populace, that huge amount of info is going to be a drain on the resources of the virus. You know what many microbes like to do with massive useless genes like that? They throw them away. Yes, that's right, it might not even take one replication in release before they chuck all your precious targeting info. And then what happens? Do they no longer have their deadly payload, or do they use it on everyone?
So leave this stuff to sci-fi writers, because reality is that viruses make HORRIBLE targeted weapons, though they aren't bad for indiscriminant killing and terror, even if they are a lot slower than bombs, guns, knives, poisons, and all other weapons in existence.
As long as they can clone our leader from his nose, who cares if they can engineer this (see 1973's sleeper http://www.imdb.com/title/tt0070707/ ). In case my country's secret services are listening, that was an attempt at a joke,
Read the "wool" series and the sequel "first shift - legacy" same basic idea except with nanomachines.
Both by hugh howey.
Reminds me of the book Alas, Babylon where everybody in the line of succession is killed by Russian nuclear weapons.. Down to the Secretary of Education, if I recall.
A witty saying proves you are wittier than the next guy.
Not sure why this was rated as 'troll'... this is basically just the FOXDIE virus from Metal Gear lol. Someone below already pointed this out, but I planned on making the post that got flagged lol.
> I remember reading that doing Aparteid the South African government worked on something like this against the African population.
They collaborated with Israel, as one wanted negro-nixing viruses and the other wanted a virus nixing the ishmaelite (arabs). Luckily this collaboration happened before the arrival of DNA chips, so they did not get much result, but human experimentation on negro and pali prisoners happened anyhow. If .il was not untouchable this scandal would have ended in a new Nurenberg doctor trial.
BTW, the top5 .il ex-leaders of this programme were eliminated when the ukrainian air defence "accidentally" missileered a russian Tu-154 airliner over the Crimea in 2001. The five were en route to the Vektor Institute in Siberia, the russians' bioweapons centre.
According to some, who are into conspiracy theories, the society of the nine unknown men was behind that downing. That is supposed to be an ancient hindi organization that was secretly set up by King Ashoka to curb warfare all over the world. A host of other bio-weapons experts culling also shows their hand still being active in the defence of mankind versus madmen.
Most the white Americans who can lay claim to long bloodlines on this side of the Atlantic share genes from all of North America's representative races. That is to say few southern whites with roots that predate the Civil War can be sure that they don't have some African or Native American blood. This, because in days gone by, if somebody could pass for white they mostly chose to do so -- hiding their ancestry. In the early 1970s I heard the great anthropologist Margaret Meade deliver lecture on this topic. The argument as I recall was statistical, and pretty incontrovertible, involving the statistical clines of the various traits.
Famously, the Vanderbilt family is descended from Anthony Janszoon van Salee who was also proudly claimed as a progenitor by Jaquiline Bouvier Kennnedy on her mother's side. Other open examples of this sort are not hard to find.
Race itself is a problematic concept for many physical anthropologists. And is arguably a very inexact classification when done with simple phenotype. But it does prove useful for forensic analysis.
"No fear. No envy. No meanness." Liam Clancy
Why target 1 annoying human being when we have flys and mosquitos to kill instead?
It's time to occupy Wall Street cell by cell!
Gesundheit Mr. Blankfein!
The kind of warfare we traditionally think about when we think about war is rendered ineffective by the current and emerging technology. If you think DNA-Specific Bio Weapons are a problem that is just race-based medicine which has been discussed on here previously. Cybernetic Warfare is about the creation of a cyborg army to use against the enemy which also creates a cyborg army. In this scenario cyborgs don't have rights, robots don't have rights, humans don't have rights either, and the soldiers are part man part machine with super powers. And no it's not a myth, it's what the military is currently working on doing.
That was "Battlestar Galactica" and the bad guys were called "cylons" not "Russians".
"Red team" biowarfare exercises, where we create biological weapons to figure out ways to "defend" against them, is the dumbest idea since sharing needles.
Our brilliant military scientists were doing red team exercises in Fort Detrick when they developed weaponized anthrax. Brilliant! Now we've demonstrated to every biology grad student in the world that it's possible to turn anthrax into a cheap, effective biological weapon, and how to do it.
Now any terrorist with a budget of $100,000 and basic bacteriological skills knows how to bring the U.S. postal system, and most of the U.S., to a halt. Then what do we do? Require photo ID to mail a letter? Autoclave the mail?
one of those where the president needs to be protected at all cost while the rest of the world can go to hell? I sometimes stand awked, euh, gawked? in awe? baffled !! by this movie mentality , but i never see it reflected in what americans say on forums anywhere. Maybe i missed the right forums then?
Free speech was meant to be free for all... how can anyone grow up in a nanny state ?
All it would take is one of these to mutate in the wild into something not so particular, and wham, worldwide pandemic.
Dr. Noah (Woody Allan) in Casino Royale made a bomb that would kill off all men over 4' 10" tall.
Have gnu, will travel.
Infowars.com and prisonplanet.com have been writing articles about this VERY thing for years folks. Took the stupid mainstream media outlets long enough to admit it!! Why do you think police departments are moving to take your DNA at every turn, why do you think the push for sending in your DNA for genetic testing, for Genetic genealogy etc.... Of course they are gathering up as much DNA as they can - then they can create DNA specific bio weapons to "kill you".
"I'm achmed the terrorist, I'll kill you!!!"
The Truth is a Virus!!!
As I suggested a dozen years ago: http://www.kurtz-fernhout.com/oscomak/fears.htm ..."
"The race is on to make the human world a better (and more resilient) place before one of these overwhelms us:
* Autonomous military robots out of control
* Nanotechnology virus / gray slime
* Ethnically targeted virus
See also though the root cause misperception: http://www.pdfernhout.net/recognizing-irony-is-a-key-to-transcending-militarism.html ..."
"Biological weapons like genetically-engineered plagues are ironic because they are about using advanced life-altering biotechnology to fight over which old-fashioned humans get to occupy the planet. Why not just use advanced biotech to let people pick their skin color, or to create living arkologies and agricultural abundance for everyone everywhere?
Think of the unknowns surrounding DNA like a lock that kept us safe from ourselves. Removing those unknowns is like telling everyone how to open all the locks on the planet (including digital locks protecting nuclear weapons). That implies our culture needs to change if we are to survive. On my website I talk about some of that. Here is another good one: http://anwot.org/
A 21st century issue: the irony of technologies of abundance in the hands of those still thinking in terms of scarcity.
> The authors propose open-sourcing the president's genetic information to a select group of security-cleared researchers
Um... I don't think whoever said that understands what "open source" actually means.
This is the same problem with Mark Shuttleworth's recent insistence that letting a some non-employees in on unreleased software projects somehow makes them more "open" or "transparent". The point is not whether the monks in your cathedral draw a paycheck. It's that you're still discriminating about who will and won't be participating in the project.
If it's not open to //anyone//, it's not open at all.
In case you were curious, the actual line of succession includes:
1. VP (Joe Biden)
2. Speaker of the House (John Boehner)
3. President Pro-Tempore of the Senate (Daniel Inouye)
4. Secretary of State (Hillary Clinton)
5. Secretary of the Treasury (Tim Geitner)
6. Secretary of Defense (Leon Panetta)
Other cabinet secretaries, but if you've gone this far down we're already in heaps of trouble.
Because the cabinet secretaries go in order of the creation of their departments, Homeland Security (Janet Napolitano) is currently last on the list.
I am officially gone from