Why Are Cells the Size They Are? Gravity May Be a Factor
carmendrahl writes "Eukaryotic cells, which are defined by having a nucleus, rarely grow larger than 10 micrometers in diameter. Scientists know a few reasons why this is so. A new study suggests another reason — gravity. Studying egg cells from the frog Xenopus laevis, which reach as big as 1 mm across and are common research tools, Princeton researchers Marina Feric and Clifford Brangwynne noticed that the insides of the eggs' nuclei settled to the bottom when they disabled a mesh made from the cytoskeleton protein actin. They think the frog eggs evolved the mesh to counteract gravity, which according to their calculations becomes significant if cells get bigger than 10 micrometers in diameter."
If I'm reading this correctly, it seems very possible that any children born in space would grow up to look like jabba the hut, since the whole gravety issue would no longer be a problem.
And if it's not obvious (mainly for our SI-challenged readers), 10 micrometers equals 0.01 mm.
c++;
let shifty eyed salesmen sell us on gravity
This makes no sense. Actin is found in practically all eukaryotic cells, including those that are tiny. TFA makes no claim that "frog eggs evolved the [actin] mesh to counteract gravity".
So this must be the Tholian mesh we hear about in Star Trek ?
It's not a typo if you understood the meaning!
This sounds like a perfect experiment for ISS. They mainly do biological experiments (it's not really a good platform for anything else), and this could be a neat result. CASIS (the ISS science institute) is always looking for new experiments and experimenters for the station.
I know micrometers can vary in size, but it seems like 10 micrometers should be around thirty inches long.
Why is it a problem if the nucleus settles to the bottom of the cell?
Bert
I've just realized (though I'm sure someone smarter than me might have done this before) that the fact that cells are more or less spherical means that they evolved microgravity or while buoyant in a liquid. So it's either the aliens in an ancient station in orbit or earth's oceans.
Curiously yours, crip.
Does this mean that a specific gravity is a requirement for cell formation? Lowering the gravity should allow for larger stable cells up until a certain point, correct?
Why is Snark Required?
I was under the impression that surface area played a significant role in this as well, which probably couldn't be easily discounted. The surface area of a sphere is 4 pi times the radius squared while the volume is 4/3 pi times the radius cubed. So, the greater the radius, the greater the ratio of volume to surface area. This usually doesn't scale well, as it means there is more mass to support and less means of getting the input and output needed to support it. I'm not saying that gravity doesn't contribute as well, but that's a fairly difficult barrier as well.
This is my signature. There are many like it, but this one is mine.
Why does gravity have the strength it has.
If Pandora's box is destined to be opened, *I* want to be the one to open it.
Does this mean there is also a "goldilocks size" to a planet for advanced life, even any life to evolve? Can it be at the correct distance from its star, have water, and still be essentially dead? Can a planet look like the Earth but because it is five times the size, be sterile?
E Proelio Veritas.
Wait, gravity affects the size of things?! Mind = blown.
Couldn't a cell be neutrally buoyant in water negating the effects of gravity? I thought it was something like surface tension keeping these things small, it would also make sense that this mesh would counteract surface tension.
neorush
Well, yea but, how can we make this Obama's fault?