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Study Linking GM Maize To Rat Tumors Is Retracted

ananyo writes "Bowing to scientists' near-universal scorn, the journal Food and Chemical Toxicology has fulfilled its threat to retract a controversial paper which claimed that a genetically modified (GM) maize causes serious disease in rats after the authors refused to withdraw it. The paper, from a research group led by Gilles-Eric Séralini, a molecular biologist at the University of Caen, France, and published in 2012, showed 'no evidence of fraud or intentional misrepresentation of the data,' said a statement from Elsevier, which publishes the journal. But the small number and type of animals used in the study means that 'no definitive conclusions can be reached.' The known high incidence of tumors in the Sprague-Dawley rat 'cannot be excluded as the cause of the higher mortality and incidence observed in the treated groups,' it added. Today's move came as no surprise. Earlier this month, the journal's editor-in-chief, Wallace Hayes, threatened retraction if Séralini refused to withdraw the paper, which is exactly what he announced at a press conference in Brussels this morning. Séralini and his team remained unrepentant, and allege that the retraction derives from the journal's editorial appointment of biologist Richard Goodman, who previously worked for biotechnology giant Monsanto for seven years."

24 of 341 comments (clear)

  1. seems a bit strange by Trepidity · · Score: 5, Insightful

    Imo, withdrawing papers makes sense mainly if there is indeed, "evidence of fraud or intentional misrepresentation of the data". Faked data doesn't help advance science, and should be purged from the record.

    But merely questionable conclusions are another story. Science is a back-and-forth process: someone publishes a study purporting to show X, and then someone else criticizes their conclusions, re-analyzes their data, attempts to replicate it, etc. Then they publish their own conclusions, purporting to show not-X. Withdrawing the original study in this case doesn't make sense to me, if it was not fraudulent: we don't typically retroactively go into old journals and blank out the articles that have subsequently turned out to be wrong. We just write new articles with better analysis.

    1. Re:seems a bit strange by cranky_chemist · · Score: 4, Insightful

      You are correct.

      Weak science and insufficient sample sizes are matters for the journal's referees to suss out and, if necessary, recommend that the journal not publish the paper. The fact that the paper passed peer review should have the journal re-examining their editorial/peer-review policies.

      Ultimately, the decision to publish (and responsibility for publishing) a paper lies with the journal's editor in chief.

    2. Re:seems a bit strange by gregor-e · · Score: 5, Insightful

      The case made for withdrawal bases its objections on bad science. The response from the authors was an ad-hominem attack against one of the editors.

    3. Re:seems a bit strange by Impy+the+Impiuos+Imp · · Score: 5, Insightful

      One cannot rule out the lesser-sized, but very real industry of trumping up faux problems for the purpose of becoming talking heads.

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      (-1: Post disagrees with my already-settled worldview) is not a valid mod option.
    4. Re:seems a bit strange by phantomfive · · Score: 5, Insightful

      Think of it this way, imagine someone did a study, where a single kid was vaccinated and later got autism. The authors of this study drew the conclusion that vaccines cause autism.

      Would you consider that to be poor science? Because that is essentially what happened here, there were obvious problems with the experiment, and the science was badly done. Elsevier was being kind by saying there was no evidence of fraud, because either it was fraud or incompetence that motivated these scientists to publish.

      What they should do is repeat the experiment with a better sample size.

      --
      "First they came for the slanderers and i said nothing."
    5. Re:seems a bit strange by plover · · Score: 5, Informative

      No, it wasn't a sample size of 1 with no control group. But according to one expert, the control group was way too small to derive statistically valid results from. According to UCD researcher Martina Newell–McGloughlin, quoted in the Discovery article (from 2012), here's what they did wrong:

      • They had a control group of 10 or 20 rats in an overall population of 200 rats (Discovery claimed the study should have had a control group that was two or three times the size of the experimental rat population.)
      • The breed of rat is tumor prone (I assume this is a problem because the researchers were pre-supposing the outcome will be tumors.)
      • The rats were two years old (a very old rat for such a study, and at two years old are likely to randomly develop tumors independently.)
      • The rats were allowed to eat unlimited quantities of the food (which is known to lead to tumors even with untainted food.)
      • They found no dose-dependent correlation between the quantity of food consumed and the tumor rate (expected in toxicology studies.)
      • They performed no independent confirmation analysis to determine if the outcome they saw could have been arrived at by chance.

      So yeah, while it's not as bad as the vaccine hoaxers, it was apparently not good research.

      --
      John
    6. Re:seems a bit strange by Chalnoth · · Score: 5, Informative

      The study wasn't just unconvincing. It was riddled with serious flaws. The first and clearest complaint: they didn't do any statistical analysis. At all. Plus, some of the GMO and pesticide groups lived noticeably longer than the control group. The highest-dose pesticide or GMO group rarely did the worst, and sometimes did the best among the groups.

      But perhaps the most damning problem of all is that the very design of the study was such that it was guaranteed that they would be able to find something wrong with the GMO/pesticide groups (at least superficially). This is due to the virtue of having in effect 20 different experimental groups of 10 mice each (10 male, 10 female for 10 different dosages of GMO's or pesticides). And they measured dozens of different things over the course of the study. In essence, if the rats in the GMO/pesticide groups hadn't had (superficially) more tumors, they would have had something else wrong with them more often, just due to random chance.

      Whether this execrable excuse of a paper is so terrible due to abject incompetence or outright fraud, it deserves to be retracted. It should never have been published in the first place, but I'm glad the journal has decided to retract it in the end.

    7. Re:seems a bit strange by AlphaWolf_HK · · Score: 4, Insightful

      Indeed let's look at it from that perspective: I'm sure you'd be rather suspect of any study that has received most of its funding from Monsanto. Likewise, would you be in favor of retracting any that reached a very shaky conclusion?

      On that same token, would you be suspect of any research study that was funded by any one (or several) companies in the organic lobby? The organic industry is massively profitable, and in fact enjoys much higher profit margins than conventional farming. The organic lobby also dumps all kinds of money into trying to prove that GM crops are harmful, and this particular study was in fact one of those they funded, in addition to this one:

      http://www.marklynas.org/2013/06/gmo-pigs-study-more-junk-science/

      Seralini is himself an anti-GMO activist who is setting out from the get-go to try to kill GMO farming. This is like having a scientist who also happens to be a catholic minister publishing a study proving that Intelligent Design is true and Evolution is false. Of course I'd retract it. And besides, it isn't even just the publisher who wants it retracted, numerous other independent researchers want the same thing because Seralini himself tried to derail the peer review process:

      http://en.wikipedia.org/wiki/S%C3%A9ralini_affair

      --
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  2. Re:maize?? by khallow · · Score: 5, Informative

    who uses the term maize any longer??

    Scientific researchers for starters. And anyone who speaks Spanish.

  3. Re:maize?? by FilmedInNoir · · Score: 5, Informative

    really?? I mean sure it is proper but who uses the term maize any longer?? (for those who are not up to date, maize is the native american term for corn)

    http://en.wikipedia.org/wiki/Maize
    TL;DR Maize is preferred in formal, scientific, and international usage because it refers specifically to this one grain, unlike corn, which has a complex variety of meanings that vary by context and geographic region.

    --
    Sig. Sig. Sputnik
  4. Re:'no definitive conclusions can be reached' by Anonymous Coward · · Score: 5, Insightful

    It's very easy to prove that something is unsafe; you simply show meaningful and reproducible examples of harm caused

    You can't prove that something is safe because you can't say beyond a doubt that something will never ever cause harm in the future. What you *can* do is show multiple studies that were looking for harm and could not meaningfully find any.

    What we know about GMOs is that there are no known examples of harm caused by them that can be reproduced by scientific peers.

  5. The US isn't always wrong. by jellomizer · · Score: 5, Interesting

    Corn is a major export crop of the United States.

    Europe government wants to promote food that is grown within the Union. It really makes sense that a European scientist would feel pressured to find evidence against a primary US import.
    As the US agriculture system is very efficient at making low cost food.

    I know it is trendy to be Anti-American as it must be some conspiracy from big US companies to hide the truth, like with Big Tobacco.
    But what if GM Food is actually perfectly safe like the science says it is.

    --
    If something is so important that you feel the need to post it on the internet... It probably isn't that important.
  6. Re:maize?? by SuricouRaven · · Score: 5, Informative

    Come to Europe. We grow corn too - but our corn is a different plant entirely.

    When European settlers came to the new world, they found a lot of new species they had no names for. So they named them after something familiar from back home. 'Corn' was named because it was the staple crop, just like the 'corn' back home - otherwise known as wheat, or the stuff cornflakes and bread are made from. This is also why you have a robin that isn't even in the same family as the european robin: It has a similar red breast, so it was called a robin.

  7. Read the definition of corn... by clonan · · Score: 4, Informative

    Gan: Corn is defined as a small hard grain/seed

    Wheat is corn
    Rice is corn
    Rye is Corn
    Millet is Corn

    Maize is also corn

    The term Corn used in supermarkets is actually slang....

    If you are going to be a vocab critic then at least get the vocab right!

  8. Re:'no definitive conclusions can be reached' by khallow · · Score: 4, Insightful

    Funny how Monsanto isn't required to definitively prove their crap is safe, but everyone else is required to definitely prove that it isn't.

    It's not that way for either party and shouldn't be ("definitively prove" is a ludicrously high threshold). This was apparently half-assed research which didn't "prove" anything.

  9. Re:maize?? by AlecC · · Score: 5, Interesting

    Maize is the term used in the UK, where corn means, usually, wheat - sometimes barley.

    Many dictionaries say that "corn" means the local most common grain crop, and therefore each grain type needs another name for use where it is not the most common.

    --
    Consciousness is an illusion caused by an excess of self consciousness.
  10. Re:'no definitive conclusions can be reached' by Samantha+Wright · · Score: 5, Insightful

    Like it or not, even big companies are innocent until proven guilty. Pending FDA approval, anyway.

    In this case it looks like the researchers were out for blood and let their dislike for Monsanto get in the way of doing the science properly—not only did they use cancer-prone rats like it says in the summary, but they didn't do enough replicates to determine if the results were actually statistically significant: the control group definitely got fewer tumours, but given the unreliability of the rat breed's tumour-forming rate it's hard to say that it wasn't just a coincidence. (And using a cancer-prone rat isn't exactly realistic to begin with; tumours grow faster whenever they get cheap and easy nutrients.)

    The paper was under close scrutiny immediately when it was published, and not just from Elsevier or Monsanto.

    --
    Bio questions? Ask me to start a Q&A journal. Computer analogies available for most topics!
  11. Re:maize?? by gregor-e · · Score: 4, Informative

    Albanian - misër
    Cebuano - mais
    Danish - majs
    Dutch - maïs
    Esperanto - maizo
    Estonian - mais
    Filipino - mais
    Finnish - maissi
    French - maïs
    German - Mais
    Haitian Creole - mayi
    Italian - mais
    Norwegian - mais
    Spanish - maíz
    Swedish - majs
    Turkish - misir

  12. Re:maize?? by ColdWetDog · · Score: 5, Funny

    Well that explains a lot of things - Healthcare, Democrat, Football.

    No wonder we're so confused. It's all your fault.

    USA! USA! USA!

    --
    Faster! Faster! Faster would be better!
  13. Re:'no definitive conclusions can be reached' by stenvar · · Score: 5, Insightful

    Funny how Monsanto isn't required to definitively prove their crap is safe, but everyone else is required to definitely prove that it isn't.

    That's because it is reasonable to assume that it is safe based on what we know about biology. Furthermore, there are no real-world indications that it is not. At this point, if you want to claim it's unsafe, you better have some strong data to back it up.

    he's basically just demonstrated that Food and Chemical Toxicology isn't interested in objective science.

    According to objective science, every widely used organism produced by genetic manipulation is safe to consume.

  14. Re:'no definitive conclusions can be reached' by Kohath · · Score: 5, Funny

    GMOs produce toxins. Those toxins have already been shown to stay in the human body almost indefinitely, compromising the human immune system. And, in perfect correlation to the spread of GMOs, all sorts of illnesses are growing and a rapid rate.

    They turned me into a newt!

    This is why they refuse to do any long-term studies.

    I got better.

  15. Re:'no definitive conclusions can be reached' by Anonymous Coward · · Score: 5, Interesting

    Uh, no, the paper was about GMO corn causing tumors in rats - are you high on weed or something?

    Anyway, there is a broad scientific consensus about the safety of GMOs. There are over 600 studies - you can start here: http://www.biofortified.org/genera/studies-for-genera/. Do you want to claim that Monsanto has the entire scientific community locked up in their sphere of influence? That's about as sensible as claiming that human-caused global warming proponents in academia are all part of some liberal conspiracy to implement communism.

    Re: "GMOs produce toxins" the only toxins that are being produced are GMOs that have been modified to produce the Bt toxin which is COMPLETELY harmless to humans. The mechanism of action of the Bt pesticide only affects insects - the digestive system of the human is completely unaffected by it. Also, you may not be aware, but Bt is available as a spray and is approved for use even on USDA Organic crops. So even if you're eating organic food, there is a very good chance you're consuming the Bt pesticide.

    If you think Bt is unsafe to humans then PROVE IT. Put up or shut up.

  16. Wrong issues with GMOs by presidenteloco · · Score: 4, Insightful

    Direct health effects of GMO foods are IMHO only the third most important potential concern with GMOs.

    The first concern is that whatever you have engineered, it is self-reproducing and could potentially take over a niche in a whole ecosystem, displacing other species or naturually adapted varieties, and you in general could not stop this if it happened. So eco-systems then become fully the responsibility of human biology tweakers.
    This seems generally unwise. The consequences of such ecosystem shifts is too complex to be predicted.

    A second concern is that each genetic engineering modification needs to be fully assessed separately from all others, due to the complexity of the systems into which they are being inserted. Or at least, very narrow equivalence classes of modifications need each to be individually, and in combination, re-tested for long term effects, viability, viability and effects of likely mutations of the tweak etc, each time they are tweaked.
    The cost of such repeated and long term safety testing is well beyond the capability of the companies producing the products, so we can be sure that such rigorous, long term, and repeated (when product is varied) testing is not being done.
    Instead, smaller numbers of specific tests on a subset of engineered varieties are generalized in alleged applicability and conclusion, to save money.

    So there is still a lot of know unknown and unknown unknown out there, and it is the kind of product that in general, self-reproduces and also expands in range.

    --

    Where are we going and why are we in a handbasket?
  17. Re:maize?? by ganjadude · · Score: 4, Informative

    Thank you for that, now i feel foolish for posting heh

    --
    have you seen my sig? there are many others like it but none that are the same