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"Fat-Burning Pill" Inches Closer To Reality
Zothecula writes with news that a fat burning pill may be on the horizon. "Researchers at Harvard University say they have identified two chemical compounds that could replace "bad" fat cells in the human body with healthy fat-burning cells, in what may be the first step toward the development of an effective medical treatment – which could even take the form of a pill – to help control weight gain. Not all fat is created equal. While white fat cells store energy as lipids and contribute to obesity, heart disease and type 2 diabetes, the less common brown fat cells pack energy in iron-rich mitochondria, have been shown to lower triglyceride levels and insulin resistance in mice, and appear to be correlated with lower body weight in humans. Brown fat makes up about five percent of the body mass of healthy newborns, helping them keep warm, and is still present in lower quantities in our neck and shoulders as adults, where it helps burn the white fat cells."
why you gotta be racist?
There's a certain subset of people for whom that is just never going to happen, or periods in lives where that's not going to happen. If we can make a magic pill, is that terrible? It's the future, let's take advantage.
Eating better cost more.
Being more active is annoying/boring.
No.
I will take the magic pill.
Your suggestion is difficult to disagree with, as long as there is no pleasanter solution. However, if a safe and effective "thin pill" can be developed, I (for one) would use it in preference to starving myself and depriving myself of favorite foods.
....it's just been discovered that the fat pill has unwanted side effects including: making you fat.
What are your feelings on birth control? Similar?
it's called "Diet and exercise"
I'm a fat, lazy old f**K whose lost 25 pounds over the last 6 months and kept it off. I hate sweating so I get nifty free apps to monitor what I eat and match that with my activity (or lack thereof) and eat accordingly.
Now I'm less fat, a little less lazy. Sadly, getting older. I need a miracle pill to fix *that*!
That's fine for those who are already healthy. For someone who has made the mistake to allow themselves to become obese it's not so easy. The body resists change and making drastic changes in lifestyle is not a simple thing. If there could be a safe way to assist in reversing obesity, alongside lifestyle changes, it could be a good way to generate results and bolster motivation.
Simplistic and self-righteous comments are not helpful.
you are welcome to your anal leakage.
No reasonable amount of discomfort and struggle are going to help a person with endocrine issues such as PCOS keeping them fat. Simple self discipline is not the answer for many individuals.
Fiddlesticks! Oh, just eat less, exercise more. But there are several things that are true that are being missed here: people who were obese as children have more fat cells than people who were starved as children. They put on weight more readily, and it comes off with more difficulty. The adult who was overweight as a child can exercise twice as much as an adult who was skinny as a child, and will have a harder time taking off weight. Next, there are people who have a difficult time getting exercise (wheelchair restrictions, COPD, physical injury, arthritis, etc.). Should these people be restricted to 20 calories per day (because they can't exercise), and suffer from nutrient restriction (and associated problems), or do they eat food that has all the nutrition they require, but get stuck with the associated fat (and thus put on weight). Your pat answer "Self discipline, eat less, exercise more" is a pile of hooey. There are people who would be better off exercising more and eating less, but its not a universal truth.
Use self discipline, eat less, eat better, be more active, and accept that discomfort and struggle may be required maintain a healthy body.
Of course, at some point with enough white fat cells, you can't do that efficiently without a system shock approach. Perhaps this pill could be coupled with a healthier lifestyle to reverse morbid obesity. Similar to how SSRIs are recommended as best combined with therapy to treat depression.
Also as others mention, there are times where "being more active" simply isn't possible.
Make sure everyone's vote counts: Verified Voting
Now if they can make the penis enlargement pills real, too, the Spam won't seem so bad!
Your suggestion is difficult to disagree with, as long as there is no pleasanter solution. However, if a safe and effective "thin pill" can be developed, I (for one) would use it in preference to starving myself and depriving myself of favorite foods.
while i myself would in fact also partake in this magic pill if it where safe and available you must take the time to ask yourself what if ?
what if we eat so much crap food that the wholesome hearty foods stop being produced
what if when we lose those foods we realize that they are in fact a big part of what and who we are
there is no truer a saying than that of "you are what you eat"
if you starve yourself of the correct foods just so you can eat what you like you will become deficient in many required substances for the human body to correctly maintain itself
McCoy: [McCoy, masked and in surgical garb, passes an elderly woman groaning on a gurney in the hallway] What's the matter with you?
Elderly patient: [weakly] Kidney
[pause]
Elderly patient: dialysis.
McCoy: [geniunely surprised] Dialysis?
[musing to himself]
McCoy: What is this, the Dark Ages?
[He turns back to the patient and hands her a large white pill]
McCoy: Here,
[pause]
McCoy: you swallow that, and if you have any more problems, just call me!
[He pats her cheek and leaves]
So maybe you should complain to them instead of spamming stories? Or are you waiting for Bennett Whats-his-name to comment?
"Transparent" is a shit show that trades on every stereotype going. A man in drag is NOT a transsexual.
There is over 1 billion people that have problems with weight. Imagine you have 1 billion clients buying your product every month to the rest of their lives... As we want to be always fit and eat what we want.
Had one of those checkups at the doctor's office and we talked about the same thing. Given the option of working out and managing my diet or a pill? Pill. Every time. Doctor agreed. Bring the future.
Until then, excercise and diet it is.
If you were me, you'd be good lookin'. - six string samurai
It already worked, Babs. May I call you Babs?
The difference is that there are people who can eat what they want and stay thin. Leavings things to evolution is often the safer bet.
Why OpalCalc is the best Windows calc
you are welcome to your anal leakage.
Citation required or put a plug in it! And no butts!
"Transparent" is a shit show that trades on every stereotype going. A man in drag is NOT a transsexual.
Yes, and Star Trek had FTL transportation, transporters, a post scarcity economy and uniformly attractive women.
It's all very nice for an hour or so a week, but most of us have to deal with this annoying concept of reality. Hell, I'd settle for just one of those.
Faster! Faster! Faster would be better!
You should probably send your idea to these researchers. They likely have never heard of it and did not realize they are wasting their time with this study.
It doesn't work. It is proven that people with real weight problems will actually lose weight to just recover it and more after 2 to 3 years. The only thing that currently gives permanent results is stomach surgery, which is a bit radical. There is piles and tons of studies to prove that.It has nothing to do with self-discipline. You have no idea what you are talking about.
Achille Talon
Hop!
Use self discipline, eat less, eat better, be more active, and accept that discomfort and struggle may be required maintain a healthy body.
Thanks, already doing all of that myself and don't have a need for such a pill. Unfortunately, that doesn't apply to everybody and I welcome such advancements where is is medically necessary because traditional methods are not appropriate for treatment.
it's hard to win when they are making foods addictive. http://www.nytimes.com/2013/02...
Anons need not reply. Questions end with a question mark.
"what if we eat so much crap food that the wholesome hearty foods stop being produced"
There really isn't a clear line between "wholesome hearty food" and "crap food". The dosage is the problem and some foods like deserts, candy, and chips are just so calorically dense and so tasty that they're almost assured to be overeaten by the majority of people.
In case society collapses and these pills can no longer be manufactured? We could be left with people that gain and retain fat easily! That would be horrible during the ensuing famine!
Star trek: ;)
Shuttles: Check, at least for a while, before we gave up
USB Key-sized storage: Check
Tablet computers: Check
Sat phones: check
Medical tricorders: there's an X-prize for that, now, right?
Attractive women in uniform: check
Still working on that warp drive, but 3D printers and increasing automation make "post-scarcity" much less of a fantasy than it used to be.
Transporters were a budget-saving hack, but have become standard fare for discussions in Theory of Identity classes in philosophy.
ST:TOS was the closest thing to good SciFi we'll likely ever see.
Socialism: a lie told by totalitarians and believed by fools.
and if it can solve a problem without discomfort and struggle why the hell not? Christ, it wasn't long ago that we expected the plague as divine retribution ya know...
Hi! I make Firefox Plug-ins. Check 'em out @ https://addons.mozilla.org/en-US/firefox/addon/youtube-mp3-podcaster/
Jeez, they couldn't have come up with this thing when I was in my teens?
So if I eat fat burning pills I'll become BURNING MAN. Swoit!
Anyone can eat what they want and maintain a reasonable weight. Either limit the portion or actually do enough physical exercise to burn off the excess calories consumed.
>there is no truer a saying than that of "you are what you eat"
Which is why we should all avoid fruits and nuts. Suckers too. Not to mention vegetables, nobody wants to be a vegetable.
--- Most topics have many sides worth arguing, allow me to take one opposite you.
You said "Attractive women in uniform: check ;)"; but that is not the same as "uniformly attractive women"....just sayin
@Random_Adam
Sometimes a sig doesn't have to be funny!!
That is one theory, another approach is to use science on what has proven to work: http://www.nwcr.ws/ A database of those who have successfully lost weight and kept it off and how they did it.
Iron-rich midichlorians? Hell yeah, you can sign me up for a test run!
That's because you're being too difficult :)
Great one mistake in the production line and the percentage of active ingredient is 10-100 times more than normal. Spontaneous human explosion becomes a reality.
Why not. Actually, I downloaded the Android Studio 1.0 to see if it was any better than the beta version (which kind of sucked, but that's just my opinion). Haven't gotten around to installing it yet, though.
"Transparent" is a shit show that trades on every stereotype going. A man in drag is NOT a transsexual.
Brown fat development is interesting. Not only it burns fat, but it also produces heat. I always thought it was really dumb to feel cold in winter while we had all that energy stored as fat on our bellies.
Right now the only trick I heard of to develop brown fat was body exposition to cold: it seems the more clothes you put on, the less heat you produce. Now we have some drug, but unfortunately TFA says it messes with inflamatory response, which is not a good news. I think most people will be better with fat rather than with a cancer.
Can't bulk and cut at the same time.... now maybe you can
"When life gives you lemons, don't make lemonade. Make life take the lemons back!" -- Cave Johnson
May be appropriate for clinically obese (abnormally low metabolism.) For everyone else who just wants to scarf junk food with no consequences, you are asking for trouble.
Whenever something sounds too good to be true, it usually isn't. I'll put some cash on this being in the Ig-Nobles in a year or two.
Back to 'Eat less and exercise', everyone. That's probably safer, anyhow.
"The greatest lesson in life is to know that even fools are right sometimes" - Winston Churchill
I think this is something that needs to be figured out. There are many people who simply cannot lose weight. The problem is that there are a lot more people who are simply too lazy to even try. I suppose it may end up being a better solution for them too. But damn have we become an impatient, instant gratification society.
Any scientific solutions which are based on the backwards assumptions of wishful thinkers and psychopaths is going to make you sicker.
Statin drugs are a prime and relevant example. Drugs designed to lower cholesterol in your body. -Based on the insanely backwards assumption that fat kills.
Fat doesn't kill. There is no 'good' and 'bad' cholesterol. (Well, I suppose the cholesterol which plaques up the arteries could be considered 'bad', but it's not there because you are eating eggs. It's there because you are eating sugars).
You want to not be fat anymore? You don't have to suffer. You don't need to starve yourself or run for miles. And you certainly don't need some screwed up toxic pill.
Eat fat. Cut out the sugars. -Bacon, not potatoes. Butter, not bread. No fruits or refined sugars. You'll look and feel like a superhero. You may even *want* to run, just because you'll be full of energy.
Caveat: Eat animal fat. Plant oils are not the same thing at all.
But pills from Big Pharma? Those people are completely nuts.
That's the least effective of the lot. Metformin (for applicable cases), T4 (ditto), phentermine/topiramate (practically for everyone) won't give you the runs.
As for pills as a "quick exit", consider those who are too fat to exercise effectively or too poor to eat optimally (good salads and fatty fish are expensive).
L2Grammarz bitch. You should also go get some pills for your paranoid conspiracy nutter nonsense. Oh and stop overriding my default font, fucker! Yet another clear sign of a conspiracy nutter. You just gotta be different...
Do you even lift, bro?
Cue all the thin people claiming that healthy eating and willpower are the keys to being thin and the fat people responding that weight is dominated by genetics.
I stole this Sig
There's a certain subset of people for whom that is just never going to happen, or periods in lives where that's not going to happen. If we can make a magic pill, is that terrible? It's the future, let's take advantage.
Wrong. Bunk. Snake-Oil. Nonesense. Most of all, Fatlogic. Not sure how the hell this was modded insightful.
There's a certain subset for whom it's never going to happen because they won't stop eating more than they should. Full stop, end of story. It's simple thermodynamics. Your Total Daily Energy Expenditure (TDEE) is how many calories your body uses up simply existing each day. Eat more than this, you gain weight. Eat less than this, you lose weight. There are plenty of online calculators to help you figure out what your specific TDEE is.
Bottom line is ANYONE can lose weight, and you don't need some "magic pill" to do so. The first step is to put down the 64oz beetus-juice and the cheese fries. Most people don't need 3000+ calories every day. Exercise helps (allows you to eat more calories because you're burning more than recovery), but you can't outrun a shitty diet. Weight loss is hard, because it requires effort, but ANYONE can do it. To think you need some pill to lose weight is nothing but fatlogic and magical thinking.
Source: I'm a (soon to be former) fatty who's been fat their entire life and has lost just over 30lbs since August, with 40 more to go. By all accounts, I should be one of the "it's never gonna happen" cases, since I tried to lose weight before and didn't (read: I thought about trying but that's as far as I got). But once I decided to get off my fat ass and actually take it seriously, the weight has been dropping off. No magic, no pills, no special juices or detox regimens, none of that. I pay attention to what I eat (novel concept, isn't it?), meaning I stopped shovelling garbage into my mouth like the fat kid I'd always been, I cut out sodas completely, and I'm actually attempting to be more active. Couldn't run for more than about a minute at a time without feeling like I was gonna die, and now I'm up to 10k at a time and training for a half-marathon this spring when I'll be at my goal weight. But even without the running, I'd still be losing weight, because I decided to stop being a human-shaped garbage disposal when it comes to food!
tl;dr - Stop making excuses or waiting for a magic pill and take control of your life. If my fat ass can get healthy, so can you.
Also, what's this "beta blocker" expensive scam? Bloodletting and pressure points are free!
I wonder how this drug would affect brown fat adipogenesis induced by cold exposure, if it would increase Brown fat at a greater rate than one does by taking 30 minute cold showers every day. (Which does work for fat loss.)
My advice is not to let all the people who sit back and claim that the obesity problem is 100% due to people sitting around and eating junk food, granted that doesn't help but everyone is different and some people just have that stubborn visceral abdominal fat (20-30 pounds or so) that though they are not considered fat by any measure .. even by their doctor, would greatly increase their health if they could lose it. I am talking about type 1 diabetics in particular for whom drugs like metformin though thy can cause some fat loss and increased insulin sensitivity, are dangerous because they can also cause severe hypoglycemia. (Metformin works pretty well for type 2 diabetics but that is another story entirely.)
Even in the case of type 2 diabetes, it is not caused just by people being lazy and eating cheetos non stop, Type 2 tends to run in families and is linked to liver disfunction, certain viral infections, cardiovascular conditions and believe it or not, type 1 diabetes within the family. I just laugh when I hear all the "OH You should just stop eating so much.." argument because with most people, their fat loss stalls or they even pack on fat and lose muscle mass when they reduce their calories too much even if they are exercising. Fat loss is just not that simple, and some people are just addicted to criticizing others instead of dealing with their own problems. I know someone will take this as flame bait, but I just don't care what they think, partly because the facts don't match their opinion, but mostly because I have seen people eat more, gain muscle mass and lose fat, without even working out that hard (1 to 3 gym sessions a week.) Everyone is different and the naysayers just tend to down play that.
I hope Harvard pursues this because in addition to eliminating a lot of suffering in the world and saving lives, this line of research is a "Billion Dollar Idea".
The original paper for this was discussed yesterday on In The Pipeline. The point was raised that the mechanism involved, the JAK-STAT signalling pathway is used quite broadly throughout the body in the control of cell growth and differentiation. There are several Janus Kinase (that's JAK) inhibitors already on the market or in development, and they are powerful immunosuppressants indicated for the treatment of things like rheumatoid arthritis or leukemia. They tend to be the sorts of drugs whose advertisements say stuff like, "Xeljanz may increase your risk of serious infection." Notably, Xeljanz (tofacitinib) popped up in the news a few months ago when it was used to grow hair in a patient with alopecia universalis (who was already taking the drug for an autoimmune disease) and the headlines exclaimed that a cure for baldness was on the horizon. Now, a single drug that burns fat, grows hair, and relieves psorasis sounds like a miracle, but the reality is that's a sign that these compounds act more broadly than is desirable.
As the paper's authors themselves put it:
"FDA staff reviewers expressed concern about the number of patients who were left out of the study because they died."
TOS was campy as fuck. It's the sci-fi counterpart to 60s batman.
TNG is where it's at.
Doesn't work for everyone, I have to run 70km/week and do weights and eat very carefully to lose any weight. On diet alone, I only start to lose weight slowly at 800Kcal/day, which is malnutrition level, I'm 6`3".
The drug Viagra has the temporary effect of converting fat stem cells into brown fat cells.
If they find a drug that can convert fat stem cells into brown fat that burns fat and has the same effect as viagra but is permanent, I want to propose a name for the drug:
"AWESOME SAUCE"
They can have that.
They mean there are many people around who have inefficient digestive systems that do not extract all of the energy from the foods they eat, or who would naturally burn more energy than their counterpart if both were in a coma. Highly efficient energy extraction is good when energy is scarce, such as a cave man winter might have had, but in a society with abundance it's not quite as useful.
Unfortunately it's not that simple. For some maintaining a reasonable weight means always being hungry. I don't think you realize this (I personally lost 60lb and have to work hard to keep it off) but it can be very miserable always being hungry. Always having that pain in the back of your mind and stomach. For some people it's too much to handle and I personally don't blame those who eat too much if they face this; it's better to enjoy food and be fat if the alternative is being miserable and always in pain. It's like complaining why people with depression just aren't happy; the same applies to why some overweight people don't stop being hungry.
Wow, no one has mentioned this yet? It's a chemical used today as a herbicide precursor and staining agent, that was originally created and used as blasting aid for explosives, that has the concerning effect of making anyone who breathes it in or ingests it lose fat. This had it prescribed as a diet aid in the 1930s.
And it works better than any other chemical in history. If you ingest it, you *will* burn fat at an incredible rate. It also will give you cataracts, peripheral neuropathy, cancer via extreme free radical production, and possibly just kill you on the spot via hyperthermia and dehydration.
After reading about it and having close friends in bodybuilding circles experiment with it, I'm incredibly skeptical about any pill that claims 'safe' fat burning. Our bodies hang onto fat for a reason, and anything that short-circuits that will probably end up with a hellish biological feedback cycle.
Let the appearance-obsessed celebrities be the guinea pigs for this one.
Some people can mouse weight earlier than others, because of metabolism and appetite. Those people don't have to try hard to lose weight. They gives them for time and energy to focus on other pursuits. For other people, they have to focus on losing or controlling their weight almost to the exclusion of everything else.
Likewise, some people are naturally more intelligent than others. But if they invented a smart pill, would you poo-poo it and tell the dumb people that they should just work harder and longer to achieve what others can do effortlessly?
It's awesome you lost weight. Good for you. But you sound like a zealot--that is, the only authenticate and leigitmate way to achieve something is and should be the way you did it.
If by that you mean "most people" I agree.
However, I think the idea that they're going to be able to magically fix your metabolism so you won't get fat by taking some drug that WON'T HARM YOU sounds a little far-fetched.
I mean, for it to work it has to change either your basic metabolism (which sounds incredibly unsafe) or interfere with the fundamental behavioral food-seeking function common to all animals.
How's that going to work?
It could only work by starving you or depriving you of your favorite foods, so no luck there.
While I agree with most of what you said, the message has a callousness that will likely cause it to fall on deaf ears. Also, to imply that it's easy or simple just to eat less or control your appetite is a bit condescending to those who have a difficult time with this. Most people lack an awareness about their appetite and take a very reactive approach to satisfying their hunger. But the truth of the matter is that sugar and carbohydrates can rule us with the fierceness of a drug or alcohol addiction. I myself have never had a trouble knowing when to stop drinking, but others, due to genetics, can't have just one.
Once I finally started to treat sugar as a drug addiction, I finally started having the success at controlling my weight. I'm currently 60lbs lighter than my peak and have a six pack for the first time in my life at 39. Now that I know how to do it, it's easy, but figuring it out and changing my habits was not.
So while I do sympathize with overweight people who struggle with controlling their appetite, I do find the fatalistic attitude that many overweight people have adopted to be quite annoying, and potentially harmful to others around them.
-- Knowledge shared is power lost. -- Aleister Crowley
I'm glad you have lost 30 lbs. since August. I started around August decreasing calorie intake and increasing exercise, reducing my daily calorie consumption by around 500 calories per day.
Have I lost weight? Not a bit. In fact, my doctor says I gained weight.
Yes, I know some of the gain could be muscle weight, but really it doesn't seem like that is the case. I don't fit clothes any better and overall just still feel the same.
So yes, I wouldn't mind having a pill if it will help people like me who actually try and get no results.
All my liberal friends think I'm a conservative, all my conservative friends think I'm a liberal.
Encouraging cells in your body to destroy/convert others? if that goes wrong, we have it
What do you do if you have constant acid reflex from your stomach that burns so badly as to impinge even on your work and the most elementary daily activities?
Seven years ago I went to the doctors with this complaint. After that check or another they said I had a bad bacteria and gave me antibiotics. Did not help. OK, says the doctor then we will stop the acid production in your stomach. Start daily intake of proton inhibitor. OK, I start and sure the acid is gone.
It was a long-held believe, which turned out to be partially true, that acid in the stomach is needed for digestion. So I was worried a bit but the pain from the acid was just too much. What I did not realize at the time is that the acid is also a protection against infections. And that this pill does not fix my issue by removing the causes for the excessive acid; it simply masks the problem.
In the last 7 years I also suffered from chronic infection in the bladder and urethra by our old friend -- the candida. When I was growing up the understanding was "never get it via sex because you will have hell of time cleaning up, can take years or never go away". I though "wow, we can do stuff against syphilis but this yeast is somehow unbeatable" [my first degree is bachelor in biochemistry and biotechnology].
Only....due to medical reasons my misuss has no libido for half a decade already, so why did I became infested with the stuff provided that the attack vector of sex is not there? And why being treated by urologists at least 4 times in 2 different countries, private or not --> I tried everything, did not help? No result whatsoever.
Until one day, 5 months ago I got really pissed and though for hours until it struck me. I picked the phone and asked my GP when did I complained from the candida for the first time and when did I start taking the proton inhibitors. Yep, I started the pills a few months before the candida arrived. So I go to the GP and tell him this. He sends me to "not a real doctor" according to the insurance companies, so I'd have to pay.
Ok, I go there and the lady says "I will take you off the proton inhibitor in one week, if you follow my advice what to eat and where to buy it from". She puts me on a "paleo diet" and we take a stool test. HALF of the buggers in my intestine was candida. HALF of more than a kilo that is there!!! Starting the diet , which is simply no grain and no sugar [diary products are OK] and baying everything fresh from the farmers directly took me off the inhibitor in 3 days. That was 5 months ago.
However, the candida is not that easy to conquer so taking caprylic acid [plenty in coconut oil; but I use highly concentrated pills] and probiotic [that brings the good bugs back] seems to be the way. I am almost off the candida infection [can always feel it in the urethra so I don't need tests anymore].
Now, you tell me that "magic pills" are the answer. So, the food industry makes us ill [sugar, fat, salt] then we get a magic pill paying even more that makes more sick and then we spend enormous resources fighting an unwinable battle, whereas the only thing needed was to keep the stomach flora happy by eating real food rather than industrial food.
Not to mention the 15 kg reduction in mass that occurred in 3 weeks! and never came back. I have now the body I had when I was 17, only with more muscles cause I do sports. Not to mention that the candida is also responsible for smelly feet and treating them with a bit of coconut oil 2 times per week removes the smell altogether.
Candidosis is the lead cause of sterility in women. If you have that much of them in you all kinds of bad stuff begins to happen --> from tiredness to swell eyes to urethra infections to even death [how do you like it guys, to be half a man for so many years because some bastards want to make profit instead of cure you --> why do you think these food specialists are shunned aside by the insurance? can you empathize with me about it? can you imagine the horror and the embarrassment?]
We'll get you in on the largest settlement since Vioxx!!
Operators standing by.
I can just see it now. Millions affected by the desire to lose weight while eating total SHIT. Fuck you, FDA!
I've been losing weight steadily for several months now, on a low-carb, high-fat, "paleo" lifestyle which includes light exercise and intermittent fasting. I do not pay any attention to calories whatsoever, I only avoid carbs and eat as much "real food" as I feel like, meaning single-ingredient, natural, fresh-cooked or raw products, as opposed to the processed "edible food-like substances" which occupy most of the shelf space in a modern supermarket.
In terms of caloric intake, my diet is about 75~80% fat, 15~20% protein, and 5~10% carbs.
I eat a lot of the following:
Raw veg: carrot sticks, celery, broccoli, cauliflower, salad.
Cooked veg: spinach, cabbage, sprouts, etc..
Fermented veg: dill pickles, sauerkraut
Dairy: butter, cream, cheese, cream-cheese, sour cream
- Do eggs count as dairy? I eat about two per day.
Nuts: almonds, walnuts, pistachios, etc..
Meat: the fattier the better, especially organ meats
Fish: the fattier the better.
I avoid all processed foods and carbs in particular: Sugar, soft drinks, fruit juice, bread, pasta, starchy veg (eg. potatoes)... and also "somewhat avoid" legumes in general and soy products in particular.
As for exercise, I don't have a regime or program, I just live in a walkable city with great public transpo, so I end up walking a couple miles per day on average. I also started using a stand-up desk last spring. I've been losing a steady 1lb per week for the last half year, and am well on the way to my target by next summer.
XML is like violence. If it doesn't solve your problem, you're not using enough of it. --AC
Forgot to mention coconut oil, which is a major contributor to the fat content of my diet.
XML is like violence. If it doesn't solve your problem, you're not using enough of it. --AC
To all of the "just eat less" people: I guess we don't need condoms & the pill either? Just fuck less, you know...
Eggs don't count as dairy. Dairy is milk and milk derived products. Eggs is eggs...
Careful though. After a few cases of spontaneous human combustion scientists admitted their fat burning pills may still need some adjustment.
The subset is probably larger than you think too. The UK is starting to realize that it's better to provide many more people with weight loss surgery than to rely on them managing to lose weight unaided because it really isn't that easy. There are often complicating health problems, sometimes due to the weight itself but often unrelated. It doesn't take much going wrong to exponentially increase the difficulty of controlling weight.
const int one = 65536; (Silvermoon, Texture.cs)
SJW, n: "Someone I don't like, and by the way I'm a fuckwit" - AC
I'm going to put this as reasonably and diplomatically as possible: eat sensibly.
If you're eating anything other than a vegan diet, you are paying for it with your quality of life and the environment - not to mention the animal lives. This is 100% within mainstream research. Find out for yourselves. Vegans eat more fruit and veg, use 18% percent of the land of meat eaters, produce 20% of the CO2 e, use 1/3 of the water and live substantially better lives while reducing the risk of several prominent diseases. Just one more thing; supplement B12. Now eat with your head, not your habit.
https://www.ncbi.nlm.nih.gov/pubmed/19351712
http://vegetarian.about.com/od/vegetarianvegan101/f/waterpollution.htm
http://veganhealth.org/articles/dxrates
In Star Trek women aren't uniformly attractive; it's simply that the ones who aren't attractive don't get promoted into the "important" ranks who get all the screen-time. Does it still seem so far-fetched?
Rodents aren't that heavy to start with.
Confucius say, "Find worm in apple - bad. Find half a worm - worse."
In Star Trek women aren't uniformly attractive; it's simply that the ones who aren't attractive don't get promoted into the "important" ranks who get all the screen-time. Does it still seem so far-fetched?
No, they just get beamed out on a transporter with the biofilter set to "hotness".
If Slashdot were chemistry it would look like this:Cadaverine
The best part is the scene later, when they're escaping the hospital:
"[Regarding the 'cloud,'] ownership was what made America different than Russia." -- Woz
The pills aren't from a company called Adipose are they?
I can't wait for next week's article about male enhancement... come on Slashdot! You can do better!
Hopefully cardiac arrests don't start up again and people lose their life after the lose their weight.
The difference is that there are people who can eat what they want and stay thin. Leavings things to evolution is often the safer bet.
I'd love to hear your proposed solution for the disabled.
Anyone can eat what they want and maintain a reasonable weight. Either limit the portion or actually do enough physical exercise to burn off the excess calories consumed.
That's like saying any of my classmates could get the same grades I did in science and math classes. All they had to do was study 40 hours per day and write down the correct answers to the exam questions. Never mind that I was able to write down the correct answers while barely studying at all.
Don't assume the fact that you're able to do something means that others can do the same thing. The human brain doesn't work that way.
I'm in my mid 40s and lost 10 kg over the last year with exercise and reducing carbs. But I wouldn't agree that sugar is just an addiction. I've found I need some fast carbs for my brain, or else I will get dizzy and have headaches. I also need a mixture of fast and slow carbs to reload after exercise. The trick is eating the right amount at the right time, not banning sugar completely.
In diabetes there is a new medication that I underwent clinical trials for that takes advantage of a certain trait of the body to dispose of sugars before the levels become too high. You see when the body becomes saturated with glucose the body takes it on itself to urinate out the excess sugars. Typically this threshold is at the 190+ level (where 140 is a normal maximum). Long story short the medication was a pill that lowered the threshold to the healthy 140 level so that even if you body took in all of that sugar it would dispose of the excess before reaching unhealthy levels.
In regards to the amount of food that we intake we don't convert all of that food into energy. Plenty of energy is lost in the inefficiency of the process of digestion. I see no reason why a pill couldn't be made to inhibit the intake, or facilitate the evacuation of, an unhealthy level of fats and carbs in the same way we can with sugars. Controlling factors like dosage and other things would be a challenge, but it is certainly plausible.
I agree with you that if you want to be truly healthy you will probably never be able to take a magic six-pack pill and exercise will always be a part of a healthy lifestyle, but for those who just want to take their weight down a level a pill like that would be a great option.
P.S. I do realize that the medicine in question is taking a different approach. I just wanted to point out that some precedent exists for this kind of thing, and it isn't all just snake oil.
"There are lies, there are damn lies, and there are statistics"
Metabolism and lipid storage is such a fundamental part of cells and boday that it may be hard to change it without unintended side effects. For example that amino acid combo that destroyed heart valves a few years ago.
It's easy to make a fat burning pill. First, you make the pill large and of sufficiently heavy metal so that it weighs anywhere from 50 to 100 pounds. Then you hold the pill over your head and do squat thrusts. Alternatively, you can also hold the pill at your waist and repeatedly curl it up to your chin. Using such a pill in this manner every day or so will eventually cause your fat to burn away.
Proverbs 21:19
A treatment that chemically reduces body fat could help lower the "barriers to entry" of a healthier lifestyle. People who are obese face greater discomfort adjusting their eating and exercise habits than those who are not. Reducing their weight somewhat with moderate use of a medication like that described in the article could mitigate that discomfort and help them make the transition to healthier habits, after which the medication may not even be needed.
Well "treat it like an addiction" doesn't necessarily mean stop. If you are addicted to pain medication but, also constantly in pain, do you stop just because you are an addict? No, but perhaps you pay more attention.
Sugar is fine in small amounts. Same is true for most things. Coffee is an addiction too. Its ok to recognize that and still drink it, but it does mean that when 4 pm rolls around, and I look down at the bottom of my cup and think "I could use some joe", I stop myself and don't make another full pot and drink it down so I am awake until 4 am
The problem with sugar is really a quantity thing, and that it has secondary effects on appetite. Which is why you want to manage sugar intake since sugar intake leads to more food cravings. The less hunger you need to resist the easier it is to eat less, and its much easier to manage that up front by managing sugar intake than ignoring hunger.
"I opened my eyes, and everything went dark again"
There's a certain subset of people for whom that is just never going to happen
I'd say that that subset of people who lack the self discipline to deny themselves in the long run would be "most people".
Anyone can say "no" to themselves once, twice, or even several times. But eventually indulgence will win out over self-discipline, because really, which one feels way the fuck better than the other?
They don't grade fathers, but if your daughter's a stripper, you fucked up. --Chris Rock
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The best way to deal with an addiction is to simply avoid the stuff you're addicted to. Alcoholics can often go dry, and spend years or decades without drinking the stuff, and then drink some again and the addiction's back. Dealing with an addiction to something that you need some of is, I suspect, considerably harder.
"When you have eliminated the unacceptable, whatever is left, however improbable, must be the truthiness" - Holmes
A friend of mine is seriously overweight and has heart problems. His doctor told him to lose weight, and he offered to go on any diet plan the doctor suggested, provided the doctor could show better than 5% success after five years. He's not on a diet, because his doctor couldn't come up with one where the chance of long-term failure wasn't completely ineffective at the p0.05 measure.
"When you have eliminated the unacceptable, whatever is left, however improbable, must be the truthiness" - Holmes
I have little doubt that most diets are completely unsuccessful after 5 years, but I also wouldn't really expect a doctor to have so much information on various diets. Your friend would probably have better luck asking a registered dietician for that information.
Anecdotally, most of the weight loss success stories that I've heard involve the person making lifestyle changes that naturally appeal to the person, and also just happen to involve increased physical activity and/or caloric restriction. So it's not a one-size-fits-all type of thing. It's more like sitting down and saying to yourself, "Self, what could I change about my life that would primarily be really fun, but would also promote weight loss?"
For me, I'm an economist by training, so I found enjoyment making a satiety vs. calories maximization problem out of it (i.e. what foods kept the hunger away for the longest time for the least amount of calories consumed?). So, I dutifully logged everything that I ate or drank in myfitnesspal and kept notes on how long everything kept me sated. Now, I have a list of foods that, for me anyway, keep the hunger at bay so I can simply eat less food and not feel tired/hungry/grouchy.
I realize that most people would hate doing this, but since I have a love for The Dismal Science, it appealed to me. Others needs to figure out what would excite them.
They don't grade fathers, but if your daughter's a stripper, you fucked up. --Chris Rock
sounds like a weird trick to burn fat!
It has changed AGAIN. Same version number in the filename. G- you are wacked!
Now it is:
Windows android-studio-bundle-135.1629389.exe
(Recommended) 868337656 bytes 1931dbaeadb52f5e0a8ba6e2ae60d9df20b2076b
Thinner
Just sayin'...
There are people who can have sex all they want and never get pregant, too, but evolution doesn't select for them, at least in subsequent generations. :-)
Check out my sci-fi/humor trilogy at PatriotsBooks.
Err... pregnant. Safari's spell checker didn't flag that. Weird.
Check out my sci-fi/humor trilogy at PatriotsBooks.
Have you had your doctor calculate the amount of calories that you need to maintain your existing weight? If so, shoot for 500 calories below that and as long as that is above 1000 calories for the day, you should lose weight. The 1000 lower limit is often considered the point at which the body goes into "starvation mode" and can start storing fat (although a friend went on a 600 calorie a day diet for a few weeks to try address his diabetes and lost a bunch of weight in the process).
the good ground has been paved over by suicidal maniacs
I see no reason why a pill couldn't be made to inhibit the intake, or facilitate the evacuation of, an unhealthy level of fats and carbs in the same way we can with sugars.
That already exists: http://www.webmd.com/diet/alli... If the first time you take it and then eat a really greasy meal (fried chicken, pizza, ribs, onion rings, etc), the next trip to the toilet will be a surprise. It will look like the Exxon Valdez ran around in the toilet bowl, but with globs of orange fat floating in the water instead. Also, when one feels and hears a rumble deep in your guts, it is time to find a bathroom as quickly as possible, because as Jim Lahey would say "the express shit train is all greased up and ready to leave the station".
the good ground has been paved over by suicidal maniacs
It isn't so much the diet as it is the will of the person to change their behavior. They need to get their mind focused on a goal and decide to not live the way that they did in the past. I used to be over 300 pounds and tried a few things over the years that didn't help very much. I'd get on a big project and gain the weight back again because I was eating crap food and was always at my desk. I had some heart rhythm problems one day and to help diagnose the problem, my doctor had me wear a heart monitor for a week. After hearing about this, my mom and my older sister drove 1000 miles (some of it through a blizzard) to take care of me. After that, I swore that I'd never put my mom through that again and I wasn't going to be the lardass carted off to the hospital in an ambulance ever again. Monitoring my food intake via smartphone apps has been a huge help in addition to making what I eat at home instead of going out or eating pre-packaged stuff. I'm nearly 100 pounds down from my max weight and would be doing better if I could just stop doing stupid things that limit my ability to exercise (hell, I didn't know that shoes could be considered "worn out" before all the tread was off the bottom and that you can mess up your legs trying to run with them - but I do now. :) ). I do creep up from time to time, but as long as the trend is going down, I'm happy. It's nice to hear "hey, man, you're getting skinny" from time to time, but I still have more to lose and until I'm at my goal, I'm still a lardass that needs to work at losing weight.
So if your friend wants a doctor to prove to him that a particular diet plan to work, then it doesn't sound to me like he's had a "I have change, or I'm going to fucking die" moment. I hope he comes to that realization before he has any serious problems and can get to a healthy weight.
the good ground has been paved over by suicidal maniacs
Who is going to bet that the company producing it is Adipose Industries. Your fat will just jump out of your body as Adipose, then run off to the Adipose Nursery Ship.
Well, that's exactly what I did, dropped 500 calories per day. No noticeable results over 4 months, when generally one should expect around 1 pound/week loss.
(And I'm nowhere near the 1000 calorie limit.)
All my liberal friends think I'm a conservative, all my conservative friends think I'm a liberal.
I have. At some point the must have passed through the stages of "a tad chubby" and "quite plump".
Yeah, those are the only healthy foods that exist. Lentils? I just made those up.
Confucius say, "Find worm in apple - bad. Find half a worm - worse."