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Ancient Viruses Altered Human Brains

giulioprisco writes: A new study from Lund University in Sweden (abstract) indicates inherited viruses that are millions of years old play an important role in building up the complex networks that characterize the human brain. The Lund study shows that retroviruses seem to play a central role in the basic functions of the brain — over the course of evolution, the viruses took an increasingly firm hold on the steering wheel in our cellular machinery. In particular, the retroviruses seem to play an important role in the regulation of which genes are to be expressed, and when."

65 of 110 comments (clear)

  1. WSB by Anonymous Coward · · Score: 4, Insightful

    William Burroughs figured this out decades ago.

  2. Re:Run! by Tablizer · · Score: 3, Funny

    Based on our collective voting patterns, YES.

  3. I KNEW IT by hel1xx · · Score: 1

    Something new to blame my lack of endowment on! Thank you!

    --
    IT Professional.
  4. Re:[bleep] have the CURE for the VIRUS. by Tablizer · · Score: 4, Funny

    This poster is likely a specimen having a recently-infected brain that may be ideal for studying this phenomenon in its early stages.

  5. Agent Smith was Right by Fire_Wraith · · Score: 5, Interesting

    Agent Smith: "I'd like to share a revelation that I've had during my time here. It came to me when I tried to classify your species and I realized that you're not actually mammals. Every mammal on this planet instinctively develops an equilibrium with the surrounding environment, but you humans do not. You move to an area and you multiply and multiply until every natural resource is consumed. The only way you can survive is to spread to another area. There is another organism on this planet that follows the same pattern. Do you know what it is? A virus. Human beings are a disease, a cancer of this planet; you are a plague and we are the cure."

    1. Re:Agent Smith was Right by plover · · Score: 3, Funny

      Put on your best Hugo Weaving voice and imagine Elrond saying "Hobbits ... are a disease; and we are the cure."

      --
      John
    2. Re: Agent Smith was Right by jd2112 · · Score: 2

      I for one welcome Hugo Weaving as our new Agent Overlord!

      --
      Any insufficiently advanced magic is indistinguishable from technology.
    3. Re:Agent Smith was Right by dasunt · · Score: 5, Interesting

      Agent Smith: "I'd like to share a revelation that I've had during my time here. It came to me when I tried to classify your species and I realized that you're not actually mammals. Every mammal on this planet instinctively develops an equilibrium with the surrounding environment, but you humans do not.

      Cute sentimentality, but considering how obviously untrue it is, that monologue always bugged me.

      First off, what areas have humans consumed so many natural resources that they can no longer survive there? About the only arguable cases I can think of is areas of desertification - and even then, humans do manage to live there.

      Second, mammals have no instinct to come to an equilibrium with their environment. E.g. rabbits in Australia - introduced a century ago, and definitely did not come to an homeostasis with the environment they found - instead, growing so numerous that they are a serious ecological problem.

    4. Re:Agent Smith was Right by Dutch+Gun · · Score: 4, Funny

      Pfft, never let facts get in the way of a good monologue.

      --
      Irony: Agile development has too much intertia to be abandoned now.
    5. Re:Agent Smith was Right by gnupun · · Score: 1

      Do you know what it is? A virus. Human beings are a disease, a cancer of this planet; you are a plague and we are the cure."

      That may be true of modern, technologically advanced humans. Those humans that have lived in primitive tribes for hundreds/thousands of years haven't harmed the environment much.

    6. Re:Agent Smith was Right by QilessQi · · Score: 3, Funny

      "I'm going to enjoy watching you die, Mister Baggins."

      "My name... is BILBO."

    7. Re: Agent Smith was Right by Anonymous Coward · · Score: 4, Insightful

      Better read Collapse by Jared Diamond before you get all cuddly with yourself. If that doesn't work for you, pick up a copy of The Limits to Growth: The 30 Year Update.

      If you don't like either of those, then look at the projections from the National Security Council regarding the future of global geopolitical stability once climate change has really kicked in. Why do you think humans are considered (by ourselves) to be the world's most 'successful' species, anyway? Ya think it has anything to do with the upcoming 6th major extinction event?

      Cultivate some more viri, will ya.

    8. Re:Agent Smith was Right by DigiShaman · · Score: 2

      "The planet will be here for a long, long, LONG time after we’re gone, and it will heal itself, it will cleanse itself, ’cause that’s what it does. It’s a self-correcting system. The air and the water will recover, the earth will be renewed. And if it’s true that plastic is not degradable, well, the planet will simply incorporate plastic into a new paradigm: the earth plus plastic. The earth doesn’t share our prejudice toward plastic. Plastic came out of the earth. The earth probably sees plastic as just another one of its children. Could be the only reason the earth allowed us to be spawned from it in the first place. It wanted plastic for itself. Didn’t know how to make it. Needed us. Could be the answer to our age-old egocentric philosophical question, “Why are we here?

      Plastic asshole.”

      -George Carlin

      --
      Life is not for the lazy.
    9. Re:Agent Smith was Right by lisaparratt · · Score: 1

      Matrix lines said in the voice he used in Priscilla, Queen of the Desert. Ruins it forever.

    10. Re:Agent Smith was Right by mrbester · · Score: 1

      Oh, so close.

      You should have used "Mr Underhill" and Frodo.

      --
      "Wait. Something's happening. It's opening up! My God, it's full of apricots!"
    11. Re:Agent Smith was Right by drinkypoo · · Score: 1

      First off, what areas have humans consumed so many natural resources that they can no longer survive there? About the only arguable cases I can think of is areas of desertification - and even then, humans do manage to live there.

      We've succeeded in turning most of the places that humans can survive without clothing into places that no longer fit that description, and we're working on the rest.

      Second, mammals have no instinct to come to an equilibrium with their environment. E.g. rabbits in Australia - introduced a century ago, and definitely did not come to an homeostasis with the environment they found - instead, growing so numerous that they are a serious ecological problem.

      Yes, the difference is that we don't have any meaningful predators. The top predator isn't kept in check by anything other than lack of food. However, our means of food production is in decline. We can survive by going hydroponic, but we're destroying the last good topsoil on the planet. Interestingly, Ukraine is the home of some of the world's best soil, in order to get into the EU they had to let in Monsanto and thus assloads of chemicals will be dumped on that soil and it will be ruined. Monsanto doesn't know how to make topsoil at high speed any more than anyone else, they specialize in murder and destruction and not in making things better.

      --
      "You're right," Fisheye says. "I should have set it on 'whip' or 'chop.'"
    12. Re: Agent Smith was Right by dasunt · · Score: 1

      I'm not saying humans are awesome, and I'm not dismissing our environmental impacts. I'm just pointing out the flaws in that speech.

      Take "Collapse" by Jared Diamond, since you mentioned it. The regions he talked about still have a human population. It's not similar to a virus, but instead a boom/bust population cycle common to some mammals (e.g. the infamous snowshoe hare)

      We may cause the end of our civilization in many ways. But humanity is likely to still be around even after the end.

    13. Re: Agent Smith was Right by Anonymous Coward · · Score: 2, Insightful

      That's the problem with people like you who filter out what they don't like. If you stop reading, you will stay dumb.

    14. Re:Agent Smith was Right by QilessQi · · Score: 1

      I doff my cap to you sir: that is indeed superior. :-)

    15. Re:Agent Smith was Right by Half-pint+HAL · · Score: 1

      Do you know what it is? A virus. Human beings are a disease, a cancer of this planet; you are a plague and we are the cure."

      That may be true of modern, technologically advanced humans. Those humans that have lived in primitive tribes for hundreds/thousands of years haven't harmed the environment much.

      Which is why there are still ancient megaherbivores on aboriginal lands in Australia, right? Or by "modern, technologically advanced humans" do you mean any people who can built boats?

      --
      Got them moderator blues I blieve I walk out the do', With these mod-points I been gettin', I 'most never post no mo'
    16. Re:Agent Smith was Right by tehcyder · · Score: 1

      You do know that The Matrix isn't a documentary or scientific paper, right?

      --
      To have a right to do a thing is not at all the same as to be right in doing it
    17. Re: Agent Smith was Right by tehcyder · · Score: 1

      I stopped reading at "climate change."

      They are your "and here's a cartoon of the prophet Mohammed" words?

      --
      To have a right to do a thing is not at all the same as to be right in doing it
    18. Re:Agent Smith was Right by Reziac · · Score: 1

      Deer will also eat themselves out of house and home, even in areas where they are native.

      And looking at the history of the Sahara (which during major warm periods has not been a desert), and the difference between grazed (vibrant) and not-grazed (desertified) -- it appears that climate changes and disuse are the culprits, far more than anything humans do.

      http://www.youtube.com/watch?v...

      --
      ~REZ~ #43301. Who'd fake being me anyway?
  6. Re:[bleep] have the CURE for the VIRUS. by FatdogHaiku · · Score: 3, Funny

    I can't removatize Bushificationisms from my head brain. Should I visitify a therapisterizer?

    A thrud xposyer will helpificate this problemification....

    --
    You have the right to remain sentient. If you give up the right to remain sentient, you will be elected to public office
  7. Sex, radiation and now viruses by Anonymous Coward · · Score: 5, Interesting

    A few years ago New Scientist had an interesting article that made me look at viruses in a different light.
    It basically said that viruses allow different species to exchange genetic material beyond what would be possible with
    sex alone. They had some example like the development of the placenta :
    http://blogs.discovermagazine.com/loom/2012/02/14/mammals-made-by-viruses/

  8. Now the anti-vax crowd by Ukab+the+Great · · Score: 1

    will latch onto the "your kid will never be anything more than a mere monkey" argument.

    1. Re:Now the anti-vax crowd by hel1xx · · Score: 1

      ______ gives you autism.

      vaccines give you autism. researching the brain will give you autism (damn fancy brain scanning equipment altering kids brains!)

      These people need to be shot.

      --
      IT Professional.
    2. Re:Now the anti-vax crowd by Anonanonaon · · Score: 1, Redundant

      These people need to be shot.

      That's not exactly a ringing endorsement for why the pro-vax side should be respected.

      "Believe what I believe or I'll kill you."

      Yeah. People who think that way are exactly the sort who should not be listened to, and for directly related reasons cannot seem to understand why anybody would question their values and assurances.

      Authoritarian followers believe what they are told, and the authorities of this world are either psychopaths or more authoritarian followers conned by the former.

    3. Re: Now the anti-vax crowd by Ukab+the+Great · · Score: 4, Funny

      Good luck with that. The raw milk they drink gives them super strength and their excellent homepathy will repair any damage.

    4. Re: Now the anti-vax crowd by jbengt · · Score: 4, Funny

      You would think that homeopaths would heartily endorse vaccines, as they seem to be one of the few treatments that successfully use small dose solutions of material that causes similar symptoms to treat (prevent) the actual disease.

    5. Re:Now the anti-vax crowd by Half-pint+HAL · · Score: 1

      I hope you're not trying to imply that an orangutang is a monkey. That's wrong, and it's completely racist.

      --
      Got them moderator blues I blieve I walk out the do', With these mod-points I been gettin', I 'most never post no mo'
    6. Re:Now the anti-vax crowd by Kaenneth · · Score: 1

      Ook.

    7. Re:Now the anti-vax crowd by Opyros · · Score: 1

      And very dangerous to say in front of the Librarian of Unseen University...

    8. Re:Now the anti-vax crowd by Half-pint+HAL · · Score: 1

      Tangerines is itself a racist term as it is often applied indiscriminately to clementines and mandarins. Please rename your society, and your fruit.

      --
      Got them moderator blues I blieve I walk out the do', With these mod-points I been gettin', I 'most never post no mo'
  9. Neuronal Tumors by Anonymous Coward · · Score: 1

    The article lies. It says, "[t]he reason the viruses are activated specifically in the brain is probably due to the fact that tumours cannot form in nerve cells, unlike in other tissues."

    Leaving aside the awkward phrasing ("form _in_ nerve cells" [emphasis added]), it turns out that 1% of brain tumors are neuronal tumors. "Tumors of the central nervous system that contain abnormal neuronal elements, termed neuronal tumors, make up approximately 1% of all brain tumors." (http://pubs.rsna.org/doi/pdf/10.1148/radiographics.22.5.g02se051177)

    That said, I think I understand the gist of the argument. But I didn't know that neuronal tumors were so rare (or supposedly impossible, according to TFA) and felt compelled to fact check that assertion.

    1. Re:Neuronal Tumors by ColdWetDog · · Score: 4, Informative

      The article lies. It says, "[t]he reason the viruses are activated specifically in the brain is probably due to the fact that tumours cannot form in nerve cells, unlike in other tissues."

      Leaving aside the awkward phrasing ("form _in_ nerve cells" [emphasis added]), it turns out that 1% of brain tumors are neuronal tumors. "Tumors of the central nervous system that contain abnormal neuronal elements, termed neuronal tumors, make up approximately 1% of all brain tumors." (http://pubs.rsna.org/doi/pdf/10.1148/radiographics.22.5.g02se051177)

      That said, I think I understand the gist of the argument. But I didn't know that neuronal tumors were so rare (or supposedly impossible, according to TFA) and felt compelled to fact check that assertion.

      I think it may refer to the fact that neural derived tumors typically form from the neural support cells (glial cells, astrocytes) rather than the axons and dentrite of a 'nerve cell'. Lousy phrasing and really a stretch as far as significance.

      Which segues into nicely hyperbolic title in TFA. What the research shows is that retroviral-derived sequences have some interesting control factors that are different from other cells. To intimate that this has anything to do with intelligence or even brain function is rather a stretch. It's a shame because the findings (a novel control pathway in the brain) is interesting all by itself.

      Sigh.

      --
      Faster! Faster! Faster would be better!
  10. Error in TFA by Prune · · Score: 5, Informative

    From the article: "tumours cannot form in nerve cells". This, of course, is BS that was discredited a couple of years ago: http://m.medicalxpress.com/new... Perhaps we should have a Slashdot discussion on lazy scientists failing to keep up with developments in their own field. If you write without bothering to read, you end up with... well, something like Slashdot...

    --
    "Politicians and diapers must be changed often, and for the same reason."
  11. Re:[bleep] have the CURE for the VIRUS. by hermitdev · · Score: 1

    Recently infected? Feels more like a primordial specimen that couldn't step out of the initial pool.

  12. lost hair by kcelery · · Score: 1, Troll

    I would consider human brain development is due to some odd genetic mutation when
    human had lost their hair. When climate changed, those who could figure out how to
    survive the cold winter lives on.

    For the hairless homo sapien to keep warm in cold climate is quite complicated as the
    fur from other animal is not quite ready to cover the body part. The cold weather forms
    some kind of selective breeding. To survive hairless, human were forced to use the brain.

    1. Re:lost hair by Gavagai80 · · Score: 3, Informative

      Unfortunately for your randomly invented theory, homo sapiens developed their brains in warm parts of Africa.

      --
      This space intentionally left blank
    2. Re:lost hair by ledow · · Score: 1

      Chances are, the hairless homo sapien came about BECAUSE it could be hairless. Not the other way around (becoming hairless and then finding a way to cope with that).

      That means either warm climates where they mainly were, or already having the knowledge on how to keep warm, or both.

      And, to be honest, plenty of hairless animals survive without having to wrap themselves in lion-skins. And if you do wrap yourself in lion skin, the shape barely matters as you can always do enough to cope with very mild climates with the barest scrap of clothing (Newcastle, UK, on a Saturday night).

    3. Re:lost hair by mrbester · · Score: 1

      Thought that was leopard skin...

      --
      "Wait. Something's happening. It's opening up! My God, it's full of apricots!"
  13. From the Enderverse by werepants · · Score: 1

    Reminds me of the virus that was found in the sequels to Ender's Game - there was an alien species that was completely dependent on the virus for survival, to the point that they believed it might have been directly responsible for their intelligence. Also, it brings to mind something like a biological version of the virus in Snow Crash, the concept that you could upload information to human minds that would instantly change the social structure as a whole.

    Once again, life imitates art.

    1. Re:From the Enderverse by righteousness · · Score: 1

      How do we know it's not actually art imitating life? Maybe Orson Scott Card already had a theory of viruses being responsible for human intelligence, or he heard it from someone else. But OSC or his scientist friend didn't want to publicise the theory for fear of being called a quack, so OSC decided to put the theory in a book?

      --
      Don't fornicate. Seriously, just don't do it.
    2. Re:From the Enderverse by Coren22 · · Score: 2

      Another one, the religion virus in Snow Crash?

      --
      APK likes to ask for responses to the same things over and over. Maybe he just likes the responses?
  14. Easter island by aepervius · · Score: 4, Insightful

    what areas have humans consumed so many natural resources that they can no longer survive there

    There isn't that many, but i think easter island would qualify.

    --
    C. Sagan : A demon haunted world:
    http://www.amazon.com/gp/product/0345409469/
    visit randi.org
    1. Re:Easter island by Anonymous Coward · · Score: 1

      There are a number of similar theories about ancient cities that were abandoned, especially in the deserts of North America. The land stops supporting the population at a certain point, and the city disbands. The Anasazi are usually held to be an example of this, but there are still questions about that, and there are other examples in the New World that might prove more reliable. In the Old World, one should remember that Babylonia was once a verdant place.

  15. Thank you by s.petry · · Score: 2

    People actually believe this crap though, and it's pretty frightening. Not saying humans don't have sociopaths and psychopaths, but if we could rid ourselves somehow of our current political classes of people the problems would not be bad.

    For example, people in Africa that have lived for countless generations on the same land are having it stolen by "tycoons" and politicians. They have to move now because they can't survive without any land to live on, and their land is converted to exploit it's resources for a select few to profit at the expense of the masses. Happens all over sadly.

    I think we should convert to a very successful time in Athens, where politicians were selected by lottery... Out with the political class and the people that can buy them.

    --

    -The wise argue that there are few absolutes, the fool argues that there are no probabilities.

    1. Re:Thank you by drinkypoo · · Score: 4, Interesting

      I think we should convert to a very successful time in Athens, where politicians were selected by lottery... Out with the political class and the people that can buy them.

      Only a portion of the politicians were selected by lottery, and only racially privileged male landowners were eligible to serve or had a vote. Once elected, they could still be bought. Their society was based on slavery. Still want to convert back to Athenian government? Guess what? It was an oligarchic republic just like what we have now.

      --
      "You're right," Fisheye says. "I should have set it on 'whip' or 'chop.'"
    2. Re:Thank you by Fire_Wraith · · Score: 1

      Obligatory HHGTTG:

      "The major problem — one of the major problems, for there are several — one of the many major problems with governing people is that of whom you get to do it; or rather of who manages to get people to let them do it to them.
      To summarize: it is a well known fact that those people who most want to rule people are, ipso facto, those least suited to do it. To summarize the summary: anyone who is capable of getting themselves made President should on no account be allowed to do the job. To summarize the summary of the summary: people are a problem."

  16. Re:[bleep] have the CURE for the VIRUS. by lisaparratt · · Score: 1

    Doing so would require the ability to breed, so that's a no go on slashdot.

  17. Re:subject nobody reads by lisaparratt · · Score: 1, Troll

    Or was it just someone terminally stupid misinterpreting their ergot-derived delusions and cursing humanity with the result?

  18. Re:I thought evolutionists had it all figured out? by Chronosphear · · Score: 1

    Scientists, as a rule, don't claim their theories are iron-clad facts - that's what the mass media does.

  19. Re:I thought evolutionists had it all figured out? by Anonymous Coward · · Score: 1

    "they had everything figured out" Where did you get this impression of science?

    I am a professional scientist. I'm a published author, and most of my colleagues are respected scientists. None of us, and no one in my field that I've ever met, thinks that they have everything figured out. And none of us have ever publicly stated so.

    In fact, science is based on the idea that we are always adding to our total body of knowledge, and that new discoveries fill in the gaps of previous theories. Over time, we approach a larger view of the total picture of how all information and knowledge relates to each other. The fact that there is always something new to learn, and new discoveries and contributions can be made by people just like you...that's what makes science so powerful and beautiful.

    Perhaps you would enjoy learning about the history of this useful thing called science that benefits you every day of your life....

    http://en.wikipedia.org/wiki/Scientific_method

  20. Can I get some more? by sabbede · · Score: 1

    That's a flu I can use!

  21. Re:I thought evolutionists had it all figured out? by Muros · · Score: 1

    The evolutionists used to say that human intelligence could be explained by evolutionary process of natural selection, and they made no reference to viruses

    The article has nothing to do with natural selection. There are two main components to evolution, mutation and natural selection. Natural selection is the description given to processes that determine what mutations remain in the gene pool, and what ones die out due to giving a poorer chance of survival and/or reproduction. The article here is about the mutation side of evolution.

  22. Re:[bleep] have the CURE for the VIRUS. by Half-pint+HAL · · Score: 1

    Indeed. I suspect this specimen is immune to these virsuses.

    --
    Got them moderator blues I blieve I walk out the do', With these mod-points I been gettin', I 'most never post no mo'
  23. Humans and green slime will be future of earth by summguy · · Score: 1

    Until or unless the earth is hit by a meteorite or volcanic action causes an ice age - The future of life on planet earth will consist of humans and ponds (lakes) of green slime used as a food source. That's it. We will grow our population to the point where all "biologically-available" carbon atoms will reside in two species of life: Humans, and our food source. All other life, and the land and energy and ecosystems that they require, will be eliminated to support the expansion of the human population. We are doing it today on a scale that is on the virge of wiping out many of the higher order species. Over time all of the rest of them will follow. The earth will resemble a mechanical structure that looks more like the death star from star wars as we cover the planet with habitation cubicals, and lakes of green slime where we recycle our dead bodies and consume the calories and nutrients of the slime. Since we are unable to biologically synthesize our own food, only the most space and energy-efficient species that will be our food source will share the planet with us. That will most likely be a photosynthetic green slime. We will reach that point because we will continue on our current path of harvesting just one more animal species for food, cut down just one more forest for space and to build homes with. Just one more - it can't hurt right? The earth will tolerate it - right? We have no ability or desire or control to reduce our population growth, and we will ultimately use all available space and energy to cover the last square foot of available space, the last calorie or kg of supportable biomass will be contained in either the body of a human or our companion food species.

  24. Re:Genetic engineering by Half-pint+HAL · · Score: 1

    Actually, these aren't viruses at all, but fragments of exploded Thetan souls....

    --
    Got them moderator blues I blieve I walk out the do', With these mod-points I been gettin', I 'most never post no mo'
  25. Re:subject nobody reads by Half-pint+HAL · · Score: 1

    It isn't stupid to believe what you see. If you're tripping and you don't know you're tripping, it seems extreeeeeeeemely real. Heck, when I was about 10 or 12, I had a dream where my Action Man was alive. It was so real that the next day I was convinced it was true, even though I was really old enough to know better...

    --
    Got them moderator blues I blieve I walk out the do', With these mod-points I been gettin', I 'most never post no mo'
  26. Darwin's Radio by weiserfireman · · Score: 1

    By Greg Bear, explored this idea of retrovirus's controlling evolution about 15 years ago. It was a very good read.

  27. Debugger by rktechhead · · Score: 1

    I am generally fascinated though also terrified by this sort of thing based on the following thought pattern: https://xkcd.com/1163/

  28. Re:Well if you think about it... by pcb · · Score: 1

    Its also highly unlikely that junk DNA would have remained in the genome if it had no purpose

    This is a common error; the reverse is actually true. Cells (and by extension, us) serve DNA. Cells (again, by extension, us) are merely vehicles for DNA to replicate - they're the unit of evolution. As a consequence, the DNA does not care whether it contains 'junk' bits. It only cares if it's faithfully copied. Btw, this is an astonishing consequence of evolution that personally blows my mind. If anybody's interested, read The Selfish Gene by Richard Dawkins.

    Note: I'm aware that DNA is a mindless macro-molecule. It just easier to anthropomorphism it for the purpose of discussion.

    PCB

    --
    'Men never commit evil so fully and joyfully as when they do it for religious convictions.' B. Pascal
  29. Re:I thought evolutionists had it all figured out? by Anguirel · · Score: 1

    The mathematicians used to say that one plus one equaled two, and they made no reference to fractions. Meaning previously, they never said fractions were required for two to appear. Now these people are saying that one-half plus one-half plus one-half plus one-half equals two. Meaning that if there were no halves, there would be no two. So why did they say they had everything figured out? Were the mathematicians wrong previously? Were they lying? Are they lying now?

    --
    ~Anguirel (lit. Living Star-Iron)
    QA: The art of telling someone that their baby is ugly without getting punched.
  30. Re:Well if you think about it... by Viol8 · · Score: 1

    Umm, no. If 1 cell takes more energy to replicate than another due to excess DNA that add nothing to its fitness in a survival situation then guess which genes will eventually win. DNA doesn't "care" at all, its simply a biological instruction list, nothing more. If its fit it'll survive, if it isn't it won't.