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Banned Weight-loss Drug Could Combat Liver Disease, Diabetes
sciencehabit writes: A drug the U.S. government once branded "extremely dangerous and not fit for human consumption" deserves a second chance, a study of rats suggests. Researchers report (abstract) that a slow-release version of the compound reverses diabetes and nonalcoholic fatty liver disease (NAFLD), an untreatable condition that can lead to cirrhosis and liver cancer.
...they fire it up and let it run for 18 hours.
When Fascism comes to America, it will call itself Anti-Fascism, and tell you to give up your guns.
Funny, I would label a rust remover "extremely dangerous and not fit for human consumption". Especially if by drinking it you are just begging for diabetes. But Cola is still not banned from the supermarket.
Nae king! Nae laird! Nae yurrupiean pressedent! We willna be fooled again!
So, is this beta or just something worse till beta comes?
JFC....why does someone have to change something JUST For the sake of change. What was wrong with they way /. has looked for the past years?
It is now a PITA to go see what comments are threaded onto my comments...whereas it was quite easy to see and tell when new ones came onto your part of the thread in response to you.
I just discovered the Soylent News thing....maybe that will indeed be the new slashdot.
This is very disappointing. Not everyone views everything through the small fucking screen of a cell phone.
Light travels faster than sound. This is why some people appear bright until you hear them speak.........
Title and summary didn't name the subject of the article, adding here.
I keep getting mod points that I can't use because the dropdown isn't rendering anymore.
X
> "extremely dangerous and not fit for human consumption"
This Slashdot beta really is getting out of control.
(-1: Post disagrees with my already-settled worldview) is not a valid mod option.
Beta no longer exists.
And now apparently instead of at least having a sandbox to make changes in, they just dump their untested code into the main Slashdot page.
How can we continue to believe in a just universe and freedom to eat crackers if we have no ale?
The drug is dinitrophenol. From the medical texts:
DNP is an ATP inhibitor, which means it prevents cell mitochondria from synthesising ATP from simple sugars. Taken in excess, DNP can cause cell death by starvation and organism death by hyperthermia (it causes an imbalance in the proton gradient which results in the release of large amounts of heat). The good: you'll be thin. The bad: you'll be dead. But at least you won't be cold.
Industrial uses include a precursor to sulphur dyes, and a component in liquid and plastic explosives. The US FDA and the UK's Food Standards Agency have both condemned DNP as a dangerous industrial chemical that should not be taken internally. Doses as low as 20mg/kg (in humans) are shown to be lethal (http://dx.doi.org/10.1081%2Fclt-200058946).
Political debates have me rolling my eyes so much I think I got optical whiplash. I should sue. - Foamy The Squirrel
http://slashdot.org/journal/21...
"Don't meddle in the affairs of a patent dragon, for thou art tasty and good with ketchup." ~ohcrapitssteve
Back in 2006 Slashdot ran a CSS redesign contest. Slashdot users overwhelmingly preferred Peter Lada's redesign:
http://web.archive.org/web/201...
Slashdot, in contravention, picked a mobile-ready, stripped down design that left a lot to be desired.
Then the beta fiasco with the Dice purchase happened in 2014, IIRC. It was presented in a VERY confrontational 'fuck you' way: get ready to have this shoved down your throat for the sake of pointless redesign. Needless to say, they gave users an option for a while and then they appeared to drop the issue.
But change HAS to happen at SOME point, because you NEED to utterly derail what works, right? In order to avoid a hue and cry, Slashdot will be making unannounced incremental changes like this. Why? Because fuck the slashdot community, that's why.
think they're trying the 7" phablet look, rather than a 2.5" squint screen. Either way, yes, this shit fails.
Political debates have me rolling my eyes so much I think I got optical whiplash. I should sue. - Foamy The Squirrel
This. Annoying as hell, my only contribution to /. is moderation, which is now impossible except on beta. Which also sucks, because I have to highlight with my mouse, then tab to the mod I want to make. Move the mouse and the damn box disappears.
Every single time they've released a new interface and taken feedback the response has been "this is worse than everything you've ever had before" almost universally. So with the latest beta they didn't bother with the "how do you like the new interface" thread because they were just going to ignore it anyway.
No, it's not beta. Beta's a lot worse (think full of AJAX). This is really a bunch of minor tweaks that kinda-sorta broke whitepacing and other things. Which is probably why it isn't as objectionable - there are still plenty of issues (missing Post buttons and the reply link often overlaps the comments), but it works and is really a bunch of minor changes than the crap that was beta.
I couldn't figure how to post to the thread with no previous comments (where was the reply button?)
I found it. There's a "Post" button just above the word "Threshold" in the green bar where you can change how comments are displayed. The word "Post" is in very slightly lighter green than the green bar itself. If you hover over it, it will turn into a gray square button with "Post" in black text. I actually found it by accident when moving the mouse around. When I realized what it was I tried to see it without hovering over it. If you know that it's there, you may see it from a normal viewing distance. But I didn't see it until I really looked closely.
The Reply to This, Parent, and Share hyperlinks use a different front and if someone has a .sig they overlap it. That's one of the problems.
No, it's not beta. Beta's a lot worse (think full of AJAX).
"Oh my God; it's full of AJAX !" was the original line in 2010, but they eventually changed it to "stars !"
It must have been something you assimilated. . . .
It's a little easier to see the word "Post" in IE than it is in FF.
I can. It's a butt ugly standard dropdown box but it works.
"I'm not much interested in interoperability. I want substitutability. I want to be able to throw your software out."
It's not known as NAFLD. It's known as NASH. Non Alcoholic SteatoHepatitis. It's even in the title of the TFA FFS.
I should use this sig to advertise my book ISBN-13 : 978-1501515132.
It was banned after it was discovered to be the cause of severe birth defects. Later it was discovered to be useful for:
URL.
Any drug that is sufficiently powerful to cure you, also has the power to hurt you. The converse is true also.
In the land of the blind, the one-eyed man is king.
"Banned Weight-loss Drug Could Combat Liver Disease, Diabetes"
And that drug? Exercise. That's right. Exercise.
In the future, our laws and the FDA are going to have to reform to adjust to a new realty. In brief, there no bad chemicals or bad drugs, only bad uses. Medicine has been so extraordinarily good at providing near miraculous cures, that we have come to have a "magic pill" mindset. This drug magically cures this disease and is "safe". The reality of medicine is a series of tradeoffs, typically the tradeoffs are greatly to our advantage, but not always. Further, it has long been known that a drug that works for one person doesn't work for someone else. There is no doubt that targeted medicine, what I consider a subset of open source medicine, is the next critical system break through. For example, this is why it is so intriguing to be putting IBM Watson on the task of medicine, Watson will be able to analysis your personal health makeup and suggest a drug appropriate for you, along with recommended possible side effect markers to watch and even possibly test for! How do you go about regulating medicine is such an environment, in the future it will no longer make sense for the FDA to "approve" or "disapprove" a drug. Rather the most sensible course will be to monitor an accurate database of effects and make sure all the participants are following correct recording procedures, along with assuring purity of products. If you follow through this logic, you will quickly realize it calls into question the current system of patents. Where an entity has a financial interest is promoting a particular drug, it also has an interest in suppressing negative information and promoting positive. Under such circumstances it isn’t strongly in anyone personal interest, other than an illegal cartel, to promote inappropriate uses of a particular drug. Obviously some system of financial rewards/incentives need to be applied, and of course no can work for free. But just as the open source software movement hasn’t killed off software companies, nor will making a space for open source medicine kill of drug companies. Indeed the free flow of ideas has only enhanced technological progress. I hope I have convinced some of you to embrace a move to open source medicine.
I prevent non-alcholic fatty liver disease with large volumes of alcohol.
I completely hate the new layout.
it looks like ass on my Mac and too many buttons don't have backgrounds until I mouseover them.
There are also loads of text layout issues.
Completely sucks.
Slashdot, do not follow in this idiotic bandwagon of "flat" or minimal UI design. It sucks ass. Ass does not want to be sucked.
- Zav - Imagine a Beowulf cluster of insensitive clods...
The power of diabetes is both a blessing and a curse. But mostly a curse.
If it aint broke, break it?
Sent from my ASR33 using ASCII
The dose makes the poison: There is an excellent book by that name: http://www.amazon.com/Dose-Mak... It should be required reading before posting on this topic.
DNP is an ATP inhibitor, which means it prevents cell mitochondria from synthesising ATP from simple sugars.
I think I understand what you're trying to say, but let me make it a bit more clear using a car analogy. Yes, you get less ATP out at the end, but that's not really the point of the drug.
DNP is an oxidative phosphorylation decoupler. What this means, it that it does the equivalent of popping your clutch into neutral, and then stomping on the gas. Your mitochondria will rev-up furiously, but no ATP is produced as you have just decoupled the connection between the engine and the wheels. In the meantime, you burn a lot of gas.
"Check out this one weird trick the FDA doesn't want you to know about a banned weight-loss drug that could combat liver disease & diabetes."