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Scientists Discover Antibody That Neutralizes 98% of HIV Strains (inquisitr.com)
An anonymous reader quotes a report from The Inquisitr: The National Institute of Allergy and Infectious Diseases (NIAID) announced this week that a "remarkable" breakthrough has been made in the study of preventing and treating the human immunodeficiency virus (HIV), the virus that leads to acquired immunodeficiency syndrome (AIDS), according to a press release posted on the agency's official website. The breakthrough centers around the discovery of a powerful antibody named N6 that is highly effective in both binding to the surface of the HIV virus and neutralizing it. The former has proved elusive in the past. "Identifying broadly neutralizing antibodies against HIV has been difficult because the virus rapidly changes its surface proteins to evade recognition by the immune system," the press release explains. The antibody was initially discovered in an HIV-positive person and has since proven to potentially neutralize 98 percent of HIV isolates, "including 16 of 20 strains resistant to other antibodies of the same class," according to the press release. Researchers have had previous success with other antibodies, but N6 appears to be more effective. The new discovery has potential benefits far beyond preventing and treating HIV as well. Studying exactly how N6 works could potentially lead to breakthroughs in other anti-viral antibodies. "Findings from the current study showed that N6 evolved a unique mode of binding that depends less on a variable area of the HIV envelope known as the V5 region and focuses more on conserved regions, which change relatively little among HIV strains," NIAID explains. "This allows N6 to tolerate changes in the HIV envelope, including the attachment of sugars in the V5 region, a major mechanism by which HIV develops resistance to other VRC01-class antibodies. Due to its potency, N6 may offer stronger and more durable prevention and treatment benefits, and researchers may be able to administer it subcutaneously (into the fat under the skin) rather than intravenously. In addition, its ability to neutralize nearly all HIV strains would be advantageous for both prevention and treatment strategies."
One of my biggest academic regrets... no organic chem, no serious cellular biology. Such an exciting time in those fields these days.
Someone had to do it.
>"Identifying broadly neutralizing antibodies against HIV has been difficult because the virus rapidly changes" ... "since proven to potentially neutralize 98 percent of HIV isolates"
So the remaining 2% quickly change to be resistant and in a few years we are back where we started again? 98% sounds great for some things. But if you had 200 fleas and got rid of 396, those remaining 4 can potentially become 200 again pretty quickly.
So, they've found James Delmore Shapely. Took them a while longer than Gibson thought, but the good part (I guess) is that the Big Quake is still up there in the future.
Faster! Faster! Faster would be better!
The other day I said that BeauHD posts crap. I compared him to that AKB guy who used to post ridiculous diatribes about hosts files, becuase he was apparently unaware of why hosts files didn't work and had to be replaced by DNS.
Anyway, I talked shit about BeauHD's submissions, so it's only fair that I now acknowledge this is a very interesting story that does belong on Slashdot. Much better than some other submissions.
preposition ending. i know.
Good. Now people can fuck all day long and not have to worry about the AIDS
Finally I can fuck dudes in prison without having to worry about needing a condom. :)
> preposition ending. i know.
Ending with a GRATUITOUS is bad. "Where is Bob at?" means exactly the same thing as "where is Bob?", so you shouldn't add "at" to the end, as it serves no purpose.
http://blog.oxforddictionaries...
Medical professionals generally don't like dealing with HIV. I work in a hospital (clinical pharmacist) and it's a giant hassle when we get an HIV positive patient.
Where is...at Bob?
Thats true at a practitioner level. I guess I'm referring to the FDA's propensity for denying approval for everything for decades. That, and big pharma wouldn't be very happy. It's like curing cancer. Yes cancer has an economic cost but it also employs countless doctors, nurses, patient transporters, oncologists, blah blah. It's a big money maker for the medical community industry. If there was a cure for cancer tomorrow, the fda would sit on it for 20 years. The excuse is that we need clinical trials on pigs, first.
Hell we even developed a fairly decent vaccine for norovirus driven gastroenteritis, but it's effectiveness was in the 60ish percent range, so the fda decided that a 100% chance of barfing was a far better option.
The best way to accelerate disease research is to infect everyone on the fda advisory boards with the diseases. And their kids. You'll see some amazing fucking progress in short order.
Let me be the first (seriously, the first despite so many other assholes who already posted) to congratulate them on this discovery. Sadly, I'm quite sure this is not a cure since I don't see how it would affect infected cells, but at least it can prevent the spread both within the body and transmission to other people.
Don't waste your vote! Vote for whoever you want, unless you live in a swing state it won't matter anyways
The problem with idiots like you is you think you understand how everything works. You're uninformed, uneducated, and you don't understand a damn thing.
It seems like we're exposed to some kind of "major breakthrough" every few months that never amounts to anything. Is this really what it appears to be, or is there some "that's all great, but..." part that people who aren't biochemist/medical professionals are missing? I'd really like to hear from people with actual medical training on this one instead of people who read three wikipedia articles and now think they know kung-fu.
BeauHD. Worst editor since kdawson.
Where Bob at?
Why bother with the gratuitous "is"?
You are welcome on my lawn.
"a fairly decent vaccine for norovirus driven gastroenteritis, but it's effectiveness"
I wish there was a vaccine against extra apostrophes... it's means it is.
But I did not read that they have figured out how to cause a person to produce this antibody. In fact, the article talked about infusing people with antibodies, but not about some vaccine that might cause people to produce the antibodies themselves. I expect that this is being pursued. Until that pursuit yields results, I don't know that this discovery will be able to counterbalance risky behavior very much.
Still going to wear condoms while fucking Bobo. Don't want to pay child support to that homo-queer, regardless.
Where is...at Bob?
Laughter aside:
"At what(which?) location is Bob?"
Once there was a man who painted a new sign for his store: "Fresh Fish for Sale"
His friend came along, saw what he was doing, and said, "Of course they're fresh, what kind of jerk sells unfresh fish?"
The man decided he was right, and crossed out the word fish.
The friend thought a bit and said, "Well........why say for sale? Why would you have fish in your store if they're not for sale?"
So,,,,,,,,,the man crossed off the words 'for sale,' becoming more efficient.
Then his friend thought some more, and said, "Ya know, everyone can tell they're fish, we can smell them from a block away."
The man crossed off the word fish, thankful he had such a wise friend.
Words are redundant, as can be proven by this following paragraph:
.
"First they came for the slanderers and i said nothing."
Where is Bob at != Where was Bob at
It becomes gratuitous when we as a species live a transcendent existence outside of spacetime.
Well not exactly.
The discovery of an antibody that targets a non-variable site is important in several ways. I'm not sure how good a therapeutic drug it will make. Antibodies are huge and hard to make so depending on the dose required it could be prohibitive to inject enough of the stuff in an active form to do any good. Massive proteins often are lousy drugs. THat's not to say that antibodies can't be used as drugs. There's a lot that are on the market now, for example Humira. But that's going after receptors in the host not viruses so it's a different regime.
But what is good about this is three things. You learn where you can bind on the virus, you learn the binding mode of the contact points, and finally you learn that that binding mode is protective across most HIV. It's not uncommon to have something that binds HIV well but fails to be protective. Given this structural knowledge one can now try to design either small molecules or other smaller proteins than an anti-body that bind in a similar manner and target either the same binding site or the same origins of protection.
Some drink at the fountain of knowledge. Others just gargle.
Been saving myself for a cure. Sure, that must be it. It sounds like a good excuse.
Corrected headline:
"Persons Immune System Discovers Antibody That Neutralizes 98% of HIV Strains; Scientists Take Credit"
Betting pool on how long it takes to patent, and who gets the patent, starts now...
Only repressed faggots call it "GRIDS".
[...] HIV virus [...]
That's the Human Immunodeficiency Virus Virus?
Great news, great work scientists... slashdot, do you even proofread?
Will defund these agencies.
Oh look, a Nevada desert conspiracy guy. Just the type I was using as an example the other day in the thread on anti-science attitudes.
You should have paid attention in your English classes.
The fda will see to that. Too much money lost by the medical profession
In only a few more weeks, the FDA will no longer be controlled by the Democrat/Republican party donor base. Things are about to get interesting.
Oh look, a Nevada desert conspiracy guy. Just the type I was using as an example the other day in the thread on anti-science attitudes.
Conspiracy is a caper that hasn't been uncovered, scandal is what it is. Recently I showed photos of my grandfathers mechanical drawing set which included a Pratt & Whitney jet engine part that had been machined into a scribe to Flight Museum on Edwards AFB along with what my great uncle spook (Jack Branham) stated about my grandfather back in '92 along with a brief bio of my grandfather and the museum director stated that this artifact should be preserved with it's backstory as close to an A-12 as possible, California Science Center on USC stated that there is rich history behind this set and should be on static display at the right museum. They also said that what my great uncle (who's name they recognized) doesn't fit their story line which is not surprising do to a change in the administration in '63 and the program being shrouded in secrecy, from what I can see they screwed up the program pretty bad and it is not like that much can't be fixed, just ain't gonna happen here. As far as the bimbo ex wife part, she left some pretty juicy evidence to what her father's buddy told me about her father working blood money along with other docs that indicate the guy is into pretty much everything and include the name of a guy that no doubt knew Sinatra. Call it Russian recruitment as a whole but being it goes back over 100 years to another ancestor of mine, not good news for Tahoe (kind of a "beginning to look a lot like Christmas" thing for the Pentagon) who where the ones that lost the most in my grandfather. Apparently my ancestor left his initials on something around the turn of last century that is something that will unlock billions in natural resources and never made it back to Wisconsin. Gang is still on north shore and already been there to tell them they're f*cked.
Your man redundantly crossed out fish twice. (yeah, I guess I could have left out redundantly)
I recognised the nouns, verbs and prepositions are in sentence structure.
The actual meaning of what you wrote still eludes me.
I recognised the nouns, verbs and prepositions are in sentence structure.
The actual meaning of what you wrote still eludes me.
AG Loretta Lynch was fired yesterday:
http://yournewswire.com/trump-...
so you don't have to play stupid,
else https://www.youtube.com/watch?...
Stupid doesn't unscrew Tahoe, grace period for them to make good on all that was expired with my fathers life, and further aggravated when the mafia was caught fixing to punch my ticket about a month and a half ago.
Being controlled by the anti-government Tea Party conservatives isn't any better. Pence will probably kill this quickly to punish the gays, drug users, and people having sex.
You should increase the voltage on your treatments.
~ People that think they are better than anyone else for any reason are the cause of all the strife in the world.
You should increase the voltage on your treatments.
No treatment, however a voltage increase in application has already been administered:
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XXX.XXX A NJ-02 USAF AFMC 412 TW/MU
Sep 12
to me
Sir,
He loved it! Thought it should be preserved with its "Backstory" as close to an A-12 as possible. I'll have him get back to you if you would like as soon as possible but this week won't work. We're basically booked up to our eyeballs for the next 7-10 days.
V/r,
On Sep 1, 2016 2:18 PM, "XXX.XXX A NJ-02 USAF AFMC 412 TW/MU" > wrote:
Sir,
Got it! I'll show this to the director and see what he thinks
V/r,
To: XXX.XXX A NJ-02 USAF AFMC 412 TW/MU >
Subject: Fwd: OXCART drafting set photos
A while back I was down there for a couple days and recently came across something. My great uncle Jack Branham said after sending my father out of the room "Strategic Reconnaissance was my baby, and it had to be cancelled, not because they cut funding but because of the way they did it and that involved your grandfather". My grandfather (Arthur Hoenig) was a 33rd degree Mason that for his act of kindness to humanity aligned and organized Children's Hospital and Shriner's fund raisers in Tahoe and Reno and died in a plane crash directly following between 4-6 million dollars wired into the program that never made it in '63. He worked as an "electrician" at American Brass & Iron in Oakland, CA but did most of his work at night. I did tell my father what my uncle said as it was looking like he was possibly under attack and/or being stalked like I was recently. My mother and I were looking through the garage and found something that my father told me once belonged to my grandfather. Pics attached... This would explain exactly why the program had to be cancelled. This could be the set used to draw the origins of AQM-60 Kingfisher/U2/SR-71 Blackbird. My uncle was very adamant that I understood what he was telling me and one of the days we were out to breakfast in town he asked me to ride in his truck with him and he said "I don't think you absorbed what I told you, I got your grandfather killed. I didn't mean to but spyplanes is a dangerous business". I asked if anything was stolen and that was when I found out about the money stolen out of the program and I told him well there you go. Not sure if he knew about my great grandfather's initials seen be myself and my father on the underground river plug beneath a Virginia City museum when I was 9 and told by my father that he never made it back to Wisconsin but that looks like a repeat crime rather than related to the JFK hit. Anyway I think that about fixes my grandfather being an unsung hero of CIA SR. Anyway my family somehow ended up in Tahoe for the last 40 years and it looks like they set us up, been trying to get out of here after being gang stalked and my business I had going down in LA folded as a result. Just me, my mother and sister left because they took out my father 3 years ago. My father told me back in '92 'shh' as we were leaving my great uncles house in north woods Wisconsin and that was the last I spoke of it until recent.
Devin Waller
Nov 1
to me
Hi,
Thank you for your interest in the California Science Center and your generous donation offer. It seems that your grandfather’s drafting set has a rich history and will be an ideal artifact for static display for the appropriate museum. We appreciate your consideration of the Science Center as a donor organization. However, we are simply not able to accept this item at this time. I’d like to recommend that you contact Cindy Macha, President of the Western Museum of Flight in Torrance (http://www.wmof.com/) or Professor William Deverell, Director of the Huntington-USC Institute (http://dornsife.usc.edu/icw).
Kind regards,
Devin
Devin Waller | Exhibit Project Manager
Samuel Oschin Air and Space Center
California Science Center
700 Exposition Park Drive, Los Angeles, CA 90037
O: (213) 744-7448
C: (310) 975-5400
dwaller@cscmail.org
CaliforniaScienceCenter.org
Please consider the environment before printing this email.
William Francis Deverell
Nov 14
to me
Thanks Mr. Hoenig – the Huntington very rarely takes on material artifacts like these, as interesting as they are – perhaps Cindy Macha will be in touch with her thoughts, too.
Best regards,
Bill Deverell
You should increase the voltage on your treatments.
There are just 5 things I care about in the Lake Tahoe basin: Water, lumber, uranium, gold and silver, and the local Sheriff's office (EDSO) has been made fully aware of that. What are they going to do? Take the Pentagon's guns away? Big pharma cartel style sales of pills for depression, paranoid schitz, or psychosis of unknown origin to the Pentagon? I'd love to see that. I don't fit any of the above diagnosis, however might I suggest writing out a diagnosis of "Really f*cking pist, is talking, and has a bat shit crazy hardon for every natural resource in the Tahoe basin, and can get at every one of them".
Oh, that's the kind of thing geniuses do.
"First they came for the slanderers and i said nothing."
After getting a course of Vit C IV 50 grams x 10, my body started to manufacture x10 more IgG for HHV6. Vit C strips off the viral proteins that protect it from the immune system (per research I read from 1950's) so that the infected cells can be targeted. HHV6 is guerrilla virus that is very sneaky and infects T-Lymphocytes and changes proteins on Natural Killer Cells to make them ineffective.
Oh no! Perhaps I'd be all broken up if I was a karma whore. I'll be sure to mention /. manipulation on the RT interview I promised Putin.
Oh, that'll teach me... NOT! You know I passed up giving the interview to Dateline when they offered to buy it for a related reason. Obviously they would edit it so it wouldn't be offensive to a couple groups of folks that screwed up CIA SR on a repeat hate crime.
How many moderator points will you burn before you figure out I'm all out of shits to give about /. karma?
What's the matter? No more mod points abuse? Perhaps Putin would like to purchase that mechanical drawing set, I know he'd love to have the trophy to display. Wouldn't that really chap ur ass? Perhaps you can squeeze one of ur buddies for some mod points to burn.
???? I read your comment several times and it seemed to me to be nothing more than word salad... a string of disconnected thoughts. I shared it with friends... no one can make any sense of what you have written.
???? I read your comment several times and it seemed to me to be nothing more than word salad... a string of disconnected thoughts. I shared it with friends... no one can make any sense of what you have written.
Just shared my opinion of the US political system and a bit of my family history, over a 100 years worth in the region of Tahoe, and a bit of trolling the AC's abuse of mod points. There's some legit emails in there involving one of them that called me out on it referencing me to being nuttier than squirrel shit. When I came back with those emails he seemed to get all personal and figures I actually care about /. karma system and began attacking mine, so I have been trying to get him to burn every mod point he can get at.