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Ethicists Advise Caution In Applying CRISPR Gene Editing To Humans (washingtonpost.com)

New submitter Baron_Yam quotes a report from Washington Post (Warning: may be paywalled; alternate source): Ethicists have been working overtime to figure out how to handle CRISPR, the revolutionary gene-editing technique that could potentially prevent congenital diseases but could also be used for cosmetic enhancements and lead to permanent, heritable changes in the human species. The latest iteration of this ongoing CRISPR debate is a report published Tuesday by the National Academy of Sciences and the National Academy of Medicine. The report, a series of guidelines written by 22 experts from multiple countries and a variety of academic specialties, presents a kind of flashing red light for CRISPR. The report did not recommend an absolute prohibition of gene editing on the human "germline" if such interventions can be proved safe. This would involve genetic changes to eggs, sperm or embryos that would persist in an adult and could be inherited by future generations. For some ethicists, that represents a slippery slope. At the conclusion of a gene-editing summit in Washington at the National Academy of Sciences in December 2015, scientists said that although some basic research could proceed, it would be irresponsible to use genetically modified germline cells for the purpose of establishing a pregnancy. But the new report takes a slightly more permissive, forward-thinking position, saying that, if and when such interventions are proved safe -- which could be in the near future -- and if numerous criteria are met to ensure that such gene editing is regulated and limited, it could potentially be used to treat rare, serious diseases. "We say proceed with all due caution, but we don't prohibit germline, after considerable discussion and debate," said Richard Hynes, an MIT biologist and one of the leaders of the new study. "We're talking only about fixing diseases."

159 comments

  1. China will jump on this by turkeydance · · Score: 1

    damn. Star Trek again with that Gene War thing.

    1. Re:China will jump on this by lord_mike · · Score: 1

      Yeah, according to Memory Alpha:

      Rising from the ashes of the Eugenics Wars of the mid-1990s, the era of World War III was a period of global conflict on Earth that eventually escalated into a nuclear cataclysm and genocidal war over issues including genetic manipulation and Human genome enhancement. World War III itself ultimately lasted from 2026 through 2053, and resulted in the death of some 600 million Humans. By that time, many of the planet's major cities and governments had been destroyed. (ENT: "In a Mirror, Darkly, Part II"; Star Trek: First Contact; VOY: "In the Flesh")

      Creepy...

    2. Re:China will jump on this by Anonymous Coward · · Score: 1

      Yeah, according to Memory Alpha:

      Gundam Seed seems a better reference.
      Gundam Seed

      Ethics aside, if I could somehow edit my genes to gain the mental acuity, reflexes, and health of a coordinator, I'd be horribly tempted, particularly if it could be done without telling anyone. Of course I'd be more wary if I planned to have children, since the risk one takes for oneself is different than one takes for their children..

    3. Re:China will jump on this by Gilgaron · · Score: 1

      If you're sufficiently fancy in your application you could avoid editing your germ line DNA...

  2. Re:Deport all smelly indo-chimps from by hackwrench · · Score: 0

    You do like to talk about yourself, don't you? Don't just convince people to deport you, leave voluntarily! Oh, you miss home and can't afford the fare? I get it now!

  3. CRISPER Gene??? by Anonymous Coward · · Score: 0

    Isn't that the space allocated to deli meats, cheeses, and whatnot as it has the drawer with the little adjustable plastic vent?

  4. So... by DontBeAMoran · · Score: 2, Funny

    What's the ETA for catgirls? ^_^

    --
    #DeleteFacebook
  5. Re:White Leftists Whine, China Creates Superhumans by swamp_ig · · Score: 2

    I'm not sure how the right of a transgender person to use a particular bathroom stands in the way of genetic engineering exactly....

    TFA is just saying be careful. Umm... duh?

    Go read about the horse named impressive. A prime example of not being careful.

  6. Bioethicist is the easiest job in the world by Anonymous Coward · · Score: 2, Insightful

    If you're a bioethicist, you basically just have to learn one word: "Don't."

    That's all they ever say when you invite one to some panel or something. If you also know how to "urge caution," you're basically guaranteed tenure.

    1. Re:Bioethicist is the easiest job in the world by s.petry · · Score: 2

      Sure, and then your boss/funding source says "your fired or collect a fat check". This is an age old problem with science and power. Sadly we can only control ourselves, so if we don't China/Russia/Germany/England (anyone with enough money and manpower) will.

      I get it, it sounds good on paper. Unfortunately morality of the scientists is not the only issue.

      --

      -The wise argue that there are few absolutes, the fool argues that there are no probabilities.

    2. Re:Bioethicist is the easiest job in the world by rickb928 · · Score: 1

      And you think bosses even consider the bioethicist points of view?

      That's almost as funny as the implicit claim that research funding is ethically constrained.

      --
      deleting the extra space after periods so i can stay relevant, yeah.
    3. Re:Bioethicist is the easiest job in the world by jbmartin6 · · Score: 1

      Exactly, what the heck is an "ethicist" anyway? Aren't we all ethicists? "Ethicists Advise Caution" is so far below interesting.

      --
      This posting is provided 'AS IS' without warranty of any kind, implied or otherwise.
    4. Re:Bioethicist is the easiest job in the world by Anonymous Coward · · Score: 0

      If you're a bioethicist, you basically just have to learn one word: "Don't."

      And you will always be right.

    5. Re:Bioethicist is the easiest job in the world by slew · · Score: 1

      And you think bosses even consider the bioethicist points of view?

      That's almost as funny as the implicit claim that research funding is ethically constrained.

      Sure, by definition bosses consider a bioethicist's (or other consultants') point of view. They consider it when they hire them and they consider it when they fire them. The employed bioethicist will probably know who paying the bills and what answer the boss wants to hear.

      Thus the comment that all research funding is ethically constrained is effectively a tautology. If the research requires funding, it mirror the ethics of the funding.

    6. Re:Bioethicist is the easiest job in the world by s.petry · · Score: 1

      As "slew" stated, I'm guessing that the bosses do hear and consider the ethics presented by the scientists. I never stated or insinuated otherwise. That does not mean, nor should it imply, that those are the only two voices in the equation especially when you look at funding. Funding is not a single layer up the food chain, it may be dozens of layers up the food chain. The public at large has no input on those decisions, and quite frankly can only find out about them after the fact.

      I'm not really sure what you were attempting to argue, but what ever it was you failed.

      --

      -The wise argue that there are few absolutes, the fool argues that there are no probabilities.

  7. Khan!!!! by www.sorehands.com · · Score: 1

    Fire up the SS Botany Bay.

    1. Re: Khan!!!! by Anonymous Coward · · Score: 0

      Star Track is ok

  8. It will be used for the traits that pay the most by FeelGood314 · · Score: 4, Interesting

    Initially this is going to be very expensive so only rich people will be able to use it for their children. Most rich people don't have genetic mutations they will pass on, they (and everyone else), will want taller, whiter, more athletic children, lighter coloured eyes, blonde hair, etc. Next we will figure out the genes for intelligence. In 15 years the very rich will be able to give these gifts to their children. In 40 years every Olympic medal will be won by one of these children. If you thought the rich had an advantage by sending their kids to better schools just imagine what this will do to inequality. (Although maybe we can hope that in 50 years this will lead to more intelligent and more compassionate politicians)

  9. The Real Effect by Anonymous Coward · · Score: 1

    All this technology does is reduce the number of aborted fetuses and rejected embryos for the benefit of fighting serious inherited conditions. Pro-lifers, you may now activate to defend this life saving technology at your pleasure.

  10. stopping the tide by Anonymous Coward · · Score: 0

    attempting to close the barn door as the tornado arrives

  11. Prohibition doesn't work by Iamthecheese · · Score: 5, Insightful

    Nature wrote a solid article on the dangers. IMO it's going to lead to some seriously damaged humans before it's closer to perfected. But IMO it will be improved until it's in common use, unless a different technique comes along. In the mean time there's little point to banning it.

    Governments that fight markets never win. If Europe and the US ban this technology that just means progress will continue in other places. And there are other reasons than eliminating disease. I could argue the ethics, but that's not the point. Like it or not people are going to do it. We live in the last fully nature-made generation.

    --
    If video games influenced behavior the Pac Man generation would be eating pills and running away from their problems.
    1. Re: Prohibition doesn't work by IMightB · · Score: 1

      I actually the "We live in the last fully nature made generation" is an extremely accurate and prescient comment, mind if I borrow it?

    2. Re:Prohibition doesn't work by serviscope_minor · · Score: 2

      Governments that fight markets never win.

      That's demonstrably not true. There used to be a healthy market for slaves, for example. Markets are not magical things.

      --
      SJW n. One who posts facts.
    3. Re:Prohibition doesn't work by Mab_Mass · · Score: 1

      Markets are not magical things.

      That's not what libertarians seem to believe.

    4. Re:Prohibition doesn't work by Glarimore · · Score: 1

      By the time the slave trade was killed in the US, it had already been eliminated in what would have been considered, at the time, to be other "1st world" (industrialized) countries that could have taken advantage of a large number of slaves and competed with the US. You picked that one sentence to criticize, but I think OP's sentiment was really "governments who fight markets, in which there is demand, never win." In the case of the slave trade, the rest of the market and its demand had already been killed.

      To be clear, I don't necessarily agree with OP's absolute claim, but I don't think your example is a counterargument to it.

    5. Re: Prohibition doesn't work by Iamthecheese · · Score: 1

      I don't even publish in closed journals. Use it, say you invented it, add to it, lie about it. Information wants to be free.

      --
      If video games influenced behavior the Pac Man generation would be eating pills and running away from their problems.
    6. Re:Prohibition doesn't work by Khashishi · · Score: 1

      But the slave trade still exists. It's just underground.

    7. Re:Prohibition doesn't work by Anonymous Coward · · Score: 0

      And there are other reasons than eliminating disease.

      Yep, I want all my female offspring to be at least DD and all males to be at least 8".

      Come on, seriously, you know that is what it is going to be used for. That and black market animal mods. You think that steroids are big in the Olympics now, just wait till they have to start screening entrants in the 100m sprint for cheetah genes.

  12. Re:It will be used for the traits that pay the mos by Truekaiser · · Score: 4, Insightful

    What was that one books solution? The time machine one? Oh right, the vast horde eats the rich.

  13. Obvious Solution by Stormy+Dragon · · Score: 3, Funny

    Ethicists Advise Caution In Applying CRISPR Gene Editing To Humans

    Only until we edit out their impulse control genes!

    1. Re:Obvious Solution by Anonymous Coward · · Score: 0

      Start with the President

    2. Re:Obvious Solution by someone1234 · · Score: 0

      The President already looks like a damaged cyborg with all those weird grimaces.

      --
      Patents Drive Free Software as Hurricanes Drive Construction Industry
  14. Re:It will be used for the traits that pay the mos by Anonymous Coward · · Score: 0

    Equality is an overrated assumption.

  15. Cant stop it by Mes · · Score: 1

    Just as you cant put the nuclear genie back in the bottle, so too genetic engineering. You may delay it, but eventually the dam will break.

  16. Catgirl hats by tepples · · Score: 0

    What's the ETA for catgirls? ^_^

    January 21, 2017

    1. Re:Catgirl hats by Opportunist · · Score: 1

      Somehow I guess I now know how a suicide bomber feels after blowing himself up, expecting 72 virgins and finds himself in the middle of a LAN party...

      --
      We used to have a Bill of Rights. Now, with the rights gone, all we have left is the bill.
  17. Brave new world by alexo · · Score: 5, Insightful

    Alpha children wear grey. They work much harder than we do, because they're so frightfully clever. I'm really awfully glad I'm a Beta, because I don't work so hard. And then we are much better than the Gammas and Deltas. Gammas are stupid. They all wear green, and Delta children wear khaki. Oh no, I don't want to play with Delta children. And Epsilons are still worse. They're too stupid to be able to read or write. Besides they wear black, which is such a beastly colour. I'm so glad I'm a Beta.

  18. khaaaaaannnnnnnn by Anonymous Coward · · Score: 0

    nuf said

    1. Re:khaaaaaannnnnnnn by Anonymous Coward · · Score: 3, Interesting

      The most basic problem is, too many folks don't know that an ancient hypothesis called "vitalism" has been thoroughly disproved. The result of that disproof is simple: Every living thing, from a microbe to a whale, is basically just as much a machine as a fuel-powered car. Including the human body. Which means that we, as owners and drivers of human bodies, while we definitely want to fix "lemon" bodies, we also should be free to decide what we want in the way of improvements. Logically, we need to think about what opinions future generations will have, regarding any improvements we choose --but they will have the same dilemma with respect to the generations that follow their choices of improvements.
      I know of some improvements that very few might disagree with: For example, the human species is descended from other species that are to manufacture their own Vitamin C, but humans lost that ability because of ancestors that lived in trees for many generations, where sources of Vitamin C made it unnecessary for bodies to make it. But then human ancestors descended from the trees, and Vitamin C was not so available as before.... By extension, it could be worth fixing up the human species to be able to internally manufacture all essential vitamins (and amino acids, too!)....

  19. "Ethicists working overtime" LOL by Anonymous Coward · · Score: 0, Interesting

    "Ethicists working overtime". "Ethicists" is a fake job held by a highly educated person with no marketable skills.

  20. Let the ethics question evolve incrementally by Applehu+Akbar · · Score: 1

    ...Like the technology itself. Right now, the focus is on using CRISPR to eliminate genetic diseases. Ethically there is no problem with that usage. But if a hipster fad develops for making their children really tall, we will have to call the ethicists back in for a discussion.

    1. Re:Let the ethics question evolve incrementally by Anonymous Coward · · Score: 3, Insightful

      Good luck with that. There are a lot of people for whom ethical considerations only apply to other people.

    2. Re:Let the ethics question evolve incrementally by mmell · · Score: 1

      Rules are for untermenschen, not ubermenschen. Almost universally, laws as well.

    3. Re:Let the ethics question evolve incrementally by Applehu+Akbar · · Score: 1

      Good luck with that. There are a lot of people for whom ethical considerations only apply to other people.

      I'm not claiming that ethicists have any power to prevent questionable uses, only that they will give us moral opinions about applications of the tech as they develop.

  21. Re:Create the perfect woman by Opportunist · · Score: 1

    And 3 feet tall with a flat head, so they can give you a blowjob while at the same time offering a surface to rest your beer on, right?

    --
    We used to have a Bill of Rights. Now, with the rights gone, all we have left is the bill.
  22. CRISPR by backslashdot · · Score: 5, Interesting

    You people do realize that the CRISPR genes of the type to do gene editing are present in strep pyogenes and also staph aureus? These bacteria, especially staph aureus, are found everywhere. That means that anyone can extract these genes and put them into a plasmid quite easily using technology such as PCR (which can be done with a thermometer, stove, and a cup of ice). The only difficult part is making oligonucleotide sequences -- which are dirt cheap to buy though not trivial for someone to make at home but if I really thought about it I am sure there is a way to do it with just household chemicals and a small lab.

    What I am saying is, if you ban this thing it will do nothing other than prevent its good use. The bad use will still be possible -- although there are tons of much easier and more effective ways to cause harm than genetic engineering -- it's rather sad to watch people get so paranoid about something like this. I mean people it's easier to cure late stage IV cancer and diabetes than it is to do something bad with genetic engineering -- yet there are tons of much easier ways to hurt people.

    1. Re:CRISPR by Anonymous Coward · · Score: 1

      Well, duh!

    2. Re:CRISPR by roman_mir · · Score: 0

      Well, these are ethicists, so their job is always to stop people from doing things they are doing because of feelings, so come on, feelings.

    3. Re:CRISPR by drinkypoo · · Score: 1

      You people do realize that the CRISPR genes of the type to do gene editing are present in strep pyogenes and also staph aureus?

      What does that have to do with anything? Is this a reply to some comment or comments? If so, you might have considered posting it as such. As it stands, it looks like you're shaking your fist and ranting at the summary in a way that makes no sense, since it doesn't say anything about gene editing as a weapon. They're specifically addressing the issue of whether using genetic modification to cure diseases is safe. There's no question among mainstream scientists whether it's ethical to create harmful things with it which target populations genetically.

      --
      "You're right," Fisheye says. "I should have set it on 'whip' or 'chop.'"
    4. Re:CRISPR by Anonymous Coward · · Score: 0

      If capitalism comes up with a way to deal with people who do millions-billions of dollars of damage because they didn't stop to think "what could go wrong" without ethicists to tell them what could go wrong, let us know. Until then, it appears that unchecked capitalism runs on the premise of:

      We have been supplying a legitimate professional demand and not once could have foreseen the unlooked-for results. I do not feel that there was any responsibility on our part.

      Which you may or may not recognize as the sentences that led to the formation of the FDA as we have it today, including all of the testing requirements to look for those "unlooked-for" results that companies feel they are not responsible for.

    5. Re:CRISPR by Anonymous Coward · · Score: 0

      I believe the GP is attempting to argue that a CRISPR ban is pointless because there isn't any way to control the materials which are needed to do CRISPR. It's relatively easy for anyone who's interested to have the tools needed at any moderately well-stocked backyard biochemistry lab.

      The disconnect here is that the GP is probably thinking about a CRISPR ban of a similar fashion to an atom bomb ban. Atom bombs are banned (except for a few governments), and as such obtaining the materials needed (uranium ore, centrifuges, etc.) is highly controlled and almost impossible unless you're a very well-funded government.

      That, though, is probably not going to be the approach taken with a CRISPR ban. You're not going to be able to control the materials to do CRISPR - especially as it's just germline human CRISPR which is being banned, not CRISPR in non-humans.

      Instead, a CRISPR ban is likely to look like the ban on murder. You can't ban/control all the tools used for murder (all you need to murder someone is a rock you picked up off the ground). Instead, the ban on murder is done through having very stiff penalties for people who carry it out. Likewise with a CRISPR ban: there's nothing physically preventing you from doing CRISPR on humans, but the second someone realizes that you are doing it, they'll come down on you like a ton of bricks, seizing all your assets and locking you up. This would dissuade most people from even considering it.

  23. Re:White Leftists Whine, China Creates Superhumans by ShanghaiBill · · Score: 1

    TFA is just saying be careful. Umm... duh?

    It is saying more than that. It is mostly hand waving blather, but mentions some specific guidelines, such as an emphasis on curing diseases rather than "enhancements". The summary is a lot worse. It uses the term "prove safe" several times, which is nonsense, since nothing can be "proved" outside of mathematics. TFA is better, and doesn't use meaningless terms like "proof" or "prove" even once.

  24. CRISPR is a great tool by Humbubba · · Score: 1
    Human Gene editing is already happening. In 2016, Dr John Zhang used his spindle nuclear transfer technique to avoid a child being born with Leigh Syndrome. CRISPR may be the greatest health care tool yet.

    CRISPR may be used for vain, nonessential and even suspect purposes. Its a brave new world, get over it.

    1. Re:CRISPR is a great tool by Anonymous Coward · · Score: 0

      Human Gene editing is already happening. In 2016, Dr John Zhang used his spindle nuclear transfer technique to avoid a child being born with Leigh Syndrome. CRISPR may be the greatest health care tool yet.

      CRISPR may be used for vain, nonessential and even suspect purposes. Its a brave new world, get over it.

      Wait until they port the male only trait from mice to humans. First generation of parents will rejoice in India and Middle East. No female offspring which need an expensive dowry. Second generation... Which second generation? That'll show them that they shouldn't diminish females.

    2. Re:CRISPR is a great tool by rickb928 · · Score: 1

      They export males already. Sending back a sustaining income to their parents is the only real goal, and grandchildren help immensely.

      This is one reason why immigration is so damned important.

      --
      deleting the extra space after periods so i can stay relevant, yeah.
    3. Re:CRISPR is a great tool by Anonymous Coward · · Score: 0

      They export males already. Sending back a sustaining income to their parents is the only real goal, and grandchildren help immensely.

      This is one reason why *emigration* is so damned important.

      FTFY. But there's no reason other countries have to enable this with their immigration laws...

    4. Re:CRISPR is a great tool by Anonymous Coward · · Score: 0

      CRISPR may be used for vain, nonessential and even suspect purposes. Its a brave new world, get over it.

      Substitute "will" for "may". The idea that this will only be used to cure disease is ludicrous. There will be attempts to make people more attractive. There will be attempts to make people better athletes. There will be attempts to create super-soldiers. The interesting question, speaking of "Brave New World", is whether there will be attempts to make people who are deliberately mentally limited so that they will happily do menial work.

  25. I want my kid to fly by Anonymous Coward · · Score: 0

    I'm going to modify his genetics so he has wings. Omg so amazing!

    1. Re:I want my kid to fly by rickb928 · · Score: 1

      And a tail that regrows. And other cute traits.

      --
      deleting the extra space after periods so i can stay relevant, yeah.
  26. Government regulation by globaljustin · · Score: 1

    Yeah, just what we need, more government regulation.

    Unless we let corporations edit the human genome, and patent human DNA, we are the enemy of the free market. /s

    --
    Thank you Dave Raggett
  27. Framing by Anonymous Coward · · Score: 2, Insightful

    The definition of "disease" has always been somewhat subjective, and I suspect it will become rather more so as technological advances continue. -PCP

    1. Re:Framing by Anonymous Coward · · Score: 0

      "The definition of "disease" has always been somewhat subjective"

      And then someone bleeds to death from a scraped knee.

  28. Re:White Leftists Whine, China Creates Superhumans by shaitand · · Score: 1

    It is saying a lot more than that, it is saying to limit technology to only treat major illnesses instead of actually giving people an advantage. There seems to be no reason for that.

  29. No shit, wally by Anonymous Coward · · Score: 0

    The rest of the world advises caution too,

  30. Much Ado About Not Much by mentil · · Score: 2

    but could also be used for cosmetic enhancements and lead to permanent, heritable changes in the human species.

    Excuse me if I'm failing to see this as a downside. Instead of repairing heritable diseases for one person, those fixes persist to their descendants as well? Sure in the short term, untested changes could lead to unknown side-effects, but that's obvious and wouldn't justify a broad ban on germline changes. Eventually/soon, germline gene editing will be cheaper than treating these diseases for even one individual, much less them and all their descendants; with socialized medicine, some countries will DEMAND gene editing, once it's cheaper. The moral panic reminds me of that surrounding in-vitro fertilization when it was novel. Remember, right now the standard practice is to do genetic testing on fetuses in the womb, and if any developmental problems are found, it's recommended the pregnancy be aborted; it's not like abortion is controversial or anything, right? To ensure I get modded to oblivion, I present this thought experiment: once inbreeding depression has been genetically eliminated, would people still consider inbreeding morally unacceptable?

    Who really cares about 'cosmetic changes'? What's considered an 'enhancement' varies from culture to culture. If e.g. Japanese want to edit their genes to have wider eyelids rather than getting them surgically widened, sure why not. Is "you are tall because your parents were tall" more comforting than "you are tall because your parents wanted you to be tall"? Do we really want to revive the spectre of 'genetic purity'?

    As for the rich being the only ones with access to this technology, leading to them becoming a master race that the unwashed masses can't compete with, that's nonsense. Consider how quickly the cost of genome sequencing has plummeted in the past 20 years; the same thing will happen with gene editing. Furthermore, consider how many parents in e.g. China are willing to do ANYTHING, including sacrifice their life (e.g. Foxconn suicides), for the sake of their children; many, many parents would be willing to save money for decades, so that before they died, they could afford gene editing for their children, assuring their offspring a better life. A MUCH more likely scenario is that gene editing is outright made illegal in a given country, so only the rich can leave the country to have it done elsewhere; this goes doubly for oppressive countries with restrictions on travel.

    --
    Corruption is convincing someone that the selfless ideal is the same as their selfish ideal.
    1. Re:Much Ado About Not Much by rickb928 · · Score: 1

      We can't seem to agree to provide needed drugs worldwide where they can treat or prevent diseases. How are we going to change ourselves to share this technology?

      No, we won't.

      --
      deleting the extra space after periods so i can stay relevant, yeah.
  31. Let's go for it. by bdwoolman · · Score: 5, Interesting

    Once upon a time dissecting people was thought unholy, but renaissance physicians like Vessalius did it anyway, risking anything from excommunication to death. Medical progress has always been hampered from time to time by unfounded pseudoreligeous fears.

    CRISPR is awesome progress. Germline enhancement is clearly the next step. Certainly a generation of smarter stronger humans can do better with things than we have. China will have no compunctions going towards enhancement. We should not allow squeamishness to prevent us from literally making better people. It won't be hard. The bar is not very high.

    --
    "No fear. No envy. No meanness." Liam Clancy
    1. Re:Let's go for it. by drinkypoo · · Score: 0

      Certainly a generation of smarter stronger humans can do better with things than we have.

      They'll be even better at oppressing people, you mean? Because let's face it, if you don't have more morality to go with more power, you just end up with more abuse of power. We need to become better before we become stronger if we hope to do anything better.

      --
      "You're right," Fisheye says. "I should have set it on 'whip' or 'chop.'"
    2. Re:Let's go for it. by Anonymous Coward · · Score: 0

      Once upon a time dissecting people was thought unholy

      The above quote is exactly why we must discuss and agree upon ethics.
      It's because you failed to clarify the conditions of dissecting people.

      For example, not only "once upon a time", but right now this very second, it is still considered unethical and wrong to dissect a living and self aware person.

      The fact remains that your failure at removing ambiguity is exactly how another person could easily interpret "It's fine to dissect people" as meaning "It's fine to dissect people, living or dead", and is exactly why discussing ethics to specify such things is so necessary.

      Gene editing is no different. There are ways to use it for good, ways to use it for bad, and also ways to use it for good that inadvertently and unexpectedly turn out to be bad.

      There is nothing wrong with discussing and specifying some of the known "bad" uses and to desire for those particular uses to not be attempted.

      And you are a shining example why even the "good" uses need to be specified in greater detail, so there is less to no room for ambiguity for those that may interpret your blanket and generic statement differently than you intended.

    3. Re:Let's go for it. by Shane_Optima · · Score: 1

      Yeah, one need look only at the status of organ transplants in China to see how this is going to proceed. They loathe the peasantry, there's a strong Confucian paternalism still present, blended with a pragmatic, anything-goes Communist attitudes... and they're big into soft and hard media controls to simply prevent their own people to figure out what's going on.

      And the motives here will be both personal (high ranking party members who want to do this with their own children) and patriotic (improving the Chinese people to help the entire country.)

      There's no good reason at all to shoot ourselves in the foot by trying to ban this, either nationally or internationally. It *is* coming. Better the research take place in the open.

  32. Better Humans? What's the downside? by NotQuiteReal · · Score: 2

    It's all part of Evolution, right?

    --
    This issue is a bit more complicated than you think.
    1. Re:Better Humans? What's the downside? by Anonymous Coward · · Score: 0

      Evolution was God's plan all along ... ...you'd hardly know it from the current neanderthals in the headlines, but have faith ! :)
      We shall evolve anyway - God has told us to.
      Amen.

  33. Population Control by lazy+genes · · Score: 0

    Now we have a new tool for population control. We need to find a way to shrink people so you can fit more of them on this planet. There is a correlation to population size and human intelligence.

  34. Fallacy by Anonymous Coward · · Score: 0

    "The Slippery Slope is a fallacy in which a person asserts that some event must inevitably follow from another without any argument for the inevitability of the event in question."

    1. Re:Fallacy by Anonymous Coward · · Score: 0

      "The Slippery Slope is a fallacy in which a person asserts that some event must inevitably follow from another without any argument for the inevitability of the event in question."

      Like trickle down economics, or market growth.

  35. Re:Create the perfect woman by Anonymous Coward · · Score: 0

    Get out of here with your midget fetish, freak.

  36. AI+ by wolfheart111 · · Score: 1

    This may be the only way to keep up with AI.

    --
    [($)]
  37. It's like caution for creating AI by Anonymous Coward · · Score: 0

    You can try to stop it and make it friendly all you want but it is being built for its one sole purpose: domination.

  38. Pointy Hats by JimSadler · · Score: 1

    The ethics priests need to take a break. Obviously any cure for any disease or condition has spin off effects that may or may not be considered negative by some people. Suppose for example we find a genetic cure for schizophrenia that persists through out generations. Obviously many people with such a condition would never be born. How the heck can anyone weigh the horrors of that illness against the potential joy or contributions that a schizophrenic might experience or create/ How about manic depression? Or how about severe mental retardation? Some people really love their handicapped children. Does that somehow imply that we should not prevent mental retardation? How the blue heck does anyone propose to carefully weigh the results of eliminating any illness? After all if we let smallpox lose on the population it would reduce traffic congestion. Who dares define what is negative or positive for the world ?

    1. Re:Pointy Hats by Rande · · Score: 4, Interesting

      Had one woman on the radio a few month ago worried about a new 99% reliable and non-invasive test for Downs Syndrome because it meant that in future Downs Children and parents would be looked down on as it meant that the child was _chosen_ to live that way.
      So yeah, there are people who would argue that we shouldn't prevent retardation.

      Of course, a lot of this is due to people worried that we'll somehow create a neo-nazi pure white aryan standard for babies, rather than the opposite.
      I hope that gengineering will lead to _more_ diversity. People of every color of the rainbow. The world needs more green and blue people. Colonize the seas with merpeople. Cute little things like cat and dog ears. Tails! Centaurs! Functional hermaphrodites (use whatever damn toilet you want)!
      That's not to say that's the only way to go. I also want cyborgs and uploaded consciousness.

    2. Re:Pointy Hats by AmiMoJo · · Score: 1

      Had one woman on the radio a few month ago worried about a new 99% reliable and non-invasive test for Downs Syndrome because it meant that in future Downs Children and parents would be looked down on as it meant that the child was _chosen_ to live that way.
      So yeah, there are people who would argue that we shouldn't prevent retardation.

      I'm really interested to explore this, if you don't mind.

      So the only option at the moment is go ahead with the birth or abort. I think the interests of the child are the most important thing to consider. Children with Downs Syndrome do have some kind of life, so I'm not sure we can automatically say that the suffering outweighs what they get from the opportunity to live.

      You seem quite certain that those fetuses should terminated. Could you explain your thoughts behind that assertion?

      I'm genuinely asking because it's not something I have given a great deal of thought to. I did read recently that a child of incest was suing their parents.

      --
      const int one = 65536; (Silvermoon, Texture.cs)
      SJW, n: "Someone I don't like, and by the way I'm a fuckwit" - AC
    3. Re:Pointy Hats by rickb928 · · Score: 1

      Precisely. For all the ethical justifications for abortion, I know very few people who would support their mother making that decision for them.

      --
      deleting the extra space after periods so i can stay relevant, yeah.
    4. Re:Pointy Hats by Rande · · Score: 1

      I'm not going to force a woman to terminate - that would be just as wrong as forcing a woman not to terminate.

      A special needs child with intellectual disabilities will cost from ~$1.5million to $3 million in care over his or her lifetime. Unless this cost is picked up by the parents, then it'll be absorbed by the State. This adds up to literally hundreds of billions of dollars that the taxpayer has to fork out for every year.

      So yeah, not impressed when women _choose_ to bring these little burdens on society into the world.

  39. Re: It will be used for the traits that pay the mo by Anonymous Coward · · Score: 1

    Actually you can buy pre-made kits on line that let you do CRISPR editing for $1200 in your own garage. Obviously you're selecting from a set of existing tools and it's not for editing human cells, but one of the reasons CRISPR is such a breakthrough is because of how cheap and simple it is - and it's very powerful.

  40. Re:White Leftists Whine, China Creates Superhumans by Anonymous Coward · · Score: 2, Interesting

    Which is all total nonsense anyway.

    Human evolution is favoring things now which could never hold within nature. People are born with inherited diseases and survive beyond their generation and produce offspring. You could say we've been favoring the wrong genetics for a long time now, so why not let science take a crack at this problem? We're provably doing far worse than even Darwin could have comprehended.

    The only reason we have to fear creating something that can outperform us is our own feeling of inadequacy. It's not that we don't want to produce something better, it's that we don't want to produce something that's better than we are. That makes us feel uncomfortable. Get over it.

  41. reversing aging by Anonymous Coward · · Score: 1

    For me, the entire point of all of this technology is to figure how to deal with aging.

    Aging is by-product of metabolising - like engine damage is a by-product of running a car engine.

    You can deal with the results in the body, but part of that probably involves some genetic modification.

    People are going on about ethics which is fine, but also loosing sight of the fact that aging is something which kills ALL of us, and fixing it something we need to do right away.

    1. Re:reversing aging by Anonymous Coward · · Score: 0

      For me, the entire point of all of this technology is to figure how to deal with aging.

      Aging is by-product of metabolising - like engine damage is a by-product of running a car engine.

      You can deal with the results in the body, but part of that probably involves some genetic modification.

      People are going on about ethics which is fine, but also loosing sight of the fact that aging is something which kills ALL of us, and fixing it something we need to do right away.

      ALL hail our eternal trumperor!

  42. Re:Create the perfect woman by Anonymous Coward · · Score: 0

    Is that you Mike?

  43. Re:White Leftists Whine, China Creates Superhumans by Anonymous Coward · · Score: 0

    My concern with giving advantages is exasperating the resource divide between the rich and poor by adding a capability divide, such that the rich get enhancements that help them get more rich whilst the poor pool up dysfunction and mediocracy.

    Thats not to say we shouldn't edit out disease genetics, since thats just mediicine.

    With all that said, genetiic enhancemennts to help people survive poverty or generally improved resiliiance is just good medicine as well, and I'll conceed that like with microsurgery (where there might be debate over whether fat trimming surgery is cosmetic or preventative) , the difference between 'enhancements' and 'prevention', might only be in the eye of the beholder

  44. Re: White Leftists Whine, China Creates Superhuman by Anonymous Coward · · Score: 0

    Exacerbating.

  45. Re:White Leftists Whine, China Creates Superhumans by Anonymous Coward · · Score: 0

    The right is more of an obstacle for this is anything. They're the one who are trying to pass a bill making children of artificial insemination illegitimate. Christ that is just cartoonishly evil.

  46. Why should I care about "ethicists"? by Angstroem · · Score: 0

    Are they people with proper scientific training in the field who can do appropriate risk assessment? Then, please, do so and provide a list of risks, potential consequences as well as measures to minimize and mitigate potential ill effects.

    Or are they basically people from some sort of so-called "social studies" and self-proclaimed "philosophers" who do nothing more than "discussing" things just based on their gut feelings and hearsay?

    Branding oneself as "ethicist" sounds an awful lot like the latter -- and I couldn't care less about those peoples' opinion.

  47. Cowardly Old Luddites by Shane_Optima · · Score: 3, Insightful

    The elimination of disease, enhancement of intelligence, etc. are good and desirable things for the vast majority of people. There will be clever arguments, not all of which are entirely wrong, that this is bad or at least highly dangerous for humanity, but outright banning it is much more dangerous. Do you think that all ~200 countries in the world will not only follow suit, but will proactively enforce the law?

    The Brave New World comparison is quite weak. Huxley's world didn't use genetic modification as I recall; they used embryological stimulation in an artificial womb. That was the key to their entire society--no more pregnancies, the government controlled all births. Now tell me, what do rich designer babies (with all of the usual attendant horrors of there being more blond people in the world, oh noes!) have to do with total and complete governmental control of reproduction and child rearing?

    These things are not only unalike; they are opposite. People having control over their bodies and genes and children is directly opposed to the government having control (and/or denying them such control through bans.) There are plenty of real concerns here, but I fear they will be completely drowned out by nonsensical BNW and GATTACA quotes.

    I fear and suspect the western world will end up intentionally abandoning this technological revolution, leaving it up to another power (perhaps the Russians or Chinese) to lead the way, very possibly in a clandestine way known only to the rich ruling elite. I must say, though, it'll be pretty amusing if the Chinese get there first and show us all just how ridiculous those "oh no, too many Nordic-looking people!" arguments are.

    1. Re:Cowardly Old Luddites by rickb928 · · Score: 2

      "with all of the usual attendant horrors of there being more blond people in the world, oh noes!"

      Hair dyes have already solved/caused this 'problem'. Simpler, somewhat less dangerous, readily accessible to most economic strata.

      Hair color ceased to be an attractor for me a long, long time ago.

      --
      deleting the extra space after periods so i can stay relevant, yeah.
    2. Re:Cowardly Old Luddites by Shane_Optima · · Score: 1

      Well, substitute blue eyes then.

      There's actually a side issue here about genetic prevalence, racial attitudes and (especially) ongoing reactionary racial biases. If one can put aside the historical baggage of Aryan theory for a moment, why *wouldn't* we want to save genetically unique features that are possessed by a small *and dwindling* minority of the population, including (but certainly not limited to) red or blond hair, Nordic-pale skin, blue eyes, etc.? Certainly, if you set this alongside the likely scenario of the much more genetically homogeneous Han people (of which there are literally an order of magnitude more than genetically Nordic people) perpetuating their ideal beauty standards[1], it is very hard to see how the commonly articulated terror of blond hair and blues eyes becoming commonplace isn't simply a remnant of anti-Nazi reactionaries (now commonly called SJWs) who are still tinkering with fairly mild forms of anti-white / anti-Nordic rhetoric--not from a genuinely anti-egalitarian place, mind, but merely in an attempt to (in their eyes) rebalance the scales.

      I mention this only as a tangent of obscure and mild intellectual interest, surely nothing that people would enjoy screaming about for hours.


      1. There is sometimes an argument that they favor having "western eyes", but a cultural aesthetic aversion to especially prominent epicanthal folds does not imply that Asian eyes aren't viewed favorably in east Asia any more than an aesthetic aversion to albinism means that blond hair and blue eyes aren't viewed aesthetically favorably in many western countries.

    3. Re:Cowardly Old Luddites by slew · · Score: 1

      Well, substitute blue eyes then.

      Colored contact lenses solved this problem long ago too...
       

      There's actually a side issue here about genetic prevalence, racial attitudes and (especially) ongoing reactionary racial biases. If one can put aside the historical baggage of Aryan theory for a moment, why *wouldn't* we want to save genetically unique features that are possessed by a small *and dwindling* minority of the population, including (but certainly not limited to) red or blond hair, Nordic-pale skin, blue eyes, etc.?

      I think there is an analogy with fuzzy cute animals are the only ones that make it to the endangered species list, but I'll leave it to others to make the case as to why that is...

    4. Re:Cowardly Old Luddites by Shane_Optima · · Score: 1

      Meh, the contacts I've seen have looked fairly crappy up close.

    5. Re:Cowardly Old Luddites by angel'o'sphere · · Score: 1

      horrors of there being more blond people in the world, oh noes!
      Actually for me and plenty of people I know "blonde" is the least desired colour for hair.

      The myth about blonds came up in african, south european, asian countries when Rome tried to conquer Germania.

      I personally prefer any other hair colour over blond, probably red being my favourite. And as a side not: no, blondes usually don't have blond pubic hair but brown or even dark brown like everyone else who is not a black haired.

      I fear and suspect the western world will end up intentionally abandoning this technological revolution, leaving it up to another power (perhaps the Russians or Chinese) to lead the way
      Does not matter. CRISPER is already so cheap that you can assume a modification will cost like $5 in 50 years.

      I must say, though, it'll be pretty amusing if the Chinese get there first
      To Mars or Moon, probably :D

      just how ridiculous those "oh no, too many Nordic-looking people!" arguments are.
      Of course they are. Some asians like europeans/nordic people. Plenty don't! And nordic people or europeans don't travel to Asia to meet nordic looking asian girls ... well, most not even travel there to meet nordic looking european girls :D

      I like asian girls with funny hair colours, but blonde does not suit them (it does not even suit most Italian, Spanish or Greek girls, just as an example)

      --
      Cost free eBook I read (by iBook/Kobo/Amazon/ObookO/Gutenberg etc.): "The Green Odyssey" by Philip Jose Farmer.
    6. Re:Cowardly Old Luddites by angel'o'sphere · · Score: 1

      There is no dwindling population of red hairs etc.
      That is an idiotic claim from popular science magazines that don't understand how genetics works.

      BTW: if you want to know how Aryans really look, I guess you can google that. Aryans as a "tribe" come from the central Perisan areas, our days Iran, the word Iran actually is a simplification of Aryan. Aryans are black haired but surprisingly with a very high percentage of blue eyed people.

      In other words: the Nazi myth about Aryans is even more retarded when you realize that the nordic and germans/teutons are not Aryans.

      --
      Cost free eBook I read (by iBook/Kobo/Amazon/ObookO/Gutenberg etc.): "The Green Odyssey" by Philip Jose Farmer.
    7. Re:Cowardly Old Luddites by angel'o'sphere · · Score: 1

      a) there is no problem to solve
      b) contact lenses would not solve it I never would stick anything like that into my eye

      --
      Cost free eBook I read (by iBook/Kobo/Amazon/ObookO/Gutenberg etc.): "The Green Odyssey" by Philip Jose Farmer.
    8. Re:Cowardly Old Luddites by Shane_Optima · · Score: 1

      That is an idiotic claim from popular science magazines that don't understand how genetics works.

      It's not true that the expression of recessive genes will dwindle in an environment where there is extensive interbreeding with a much larger number of people with a dominant gene? it's not true that darker haired/eyed people have higher birth rates than those of Nordic complexion?

      Yes yes, I understand that if you are starting from an assumption that neither gene affects (nor is statistically correlated with) survivability or reproductive chances then no gene will be increasing or decreasing in prevalence. Except to the extent that population bottlenecks have a larger chance of wiping out the rarer-gene.

    9. Re:Cowardly Old Luddites by angel'o'sphere · · Score: 2

      Depends what you want to ask, and if you know what 'expression' means.

      Point is: no, the question if a bene is regressive or dominat (outdated terms btw, as both twrms are wrong) is irrelevant for 'heritage'. You simply inherit both and the 'more dominant' is 'more epxressed'. The recessive one is not lost in any way.

      it's not true that darker haired/eyed people have higher birth rates than those of Nordic complexion?
      Only if you want to be pedantic. But as most nordics breed amoung themselves and most 'browns' breed amoun themselves ... it had no effect on the genepool. You can only argue that the 'browns' still increase in population and the nordic are stagnant. So the percentage of blond or raid looking at the world wide population is becomming less.

      Who would care about that?

      Except to the extent that population bottlenecks have a larger chance of wiping out the rarer-gene.
      If the owners of that gene don't 'breed' succesfully ... if they do: no.

      --
      Cost free eBook I read (by iBook/Kobo/Amazon/ObookO/Gutenberg etc.): "The Green Odyssey" by Philip Jose Farmer.
  48. Re: It will be used for the traits that pay the mo by zijus · · Score: 2

    Actually you can buy pre-made kits on line that let you do CRISPR editing for $1200 in your own garage. Obviously you're selecting from a set of existing tools and it's not for editing human cells, but one of the reasons CRISPR is such a breakthrough is because of how cheap and simple it is - and it's very powerful.

    +++ This is the very point. G*ogle "CRISPR kit" and... blamo within 5 top match : http://www.origene.com/CRISPR-.... Page "CRISPR-Cas9 Vectors" : nothing over 500$. All possible in your kitchen. What some of us don't get IMO is we are not talking about a revolution here but instead a full scale disruption. I know ([fr] https://www.franceinter.fr/emi...) some national defence office are well on the case. Already. We all know whether legal or not is irrelevant. It will be done. Don't we know ?

  49. Re:It will be used for the traits that pay the mos by AmiMoJo · · Score: 0

    The best way to handle it is to only allow modifications that are available to everyone. Then the only way that the rich will legally be able to get those modifications will be to push for them to be available to everyone for free, and they will use their power and wealth to make it happen.

    That doesn't solve the problem of different countries having different rules, but as most of the wealth is concentrated in the larger blocks (EU, US) and countries that generally respect international law, I'm sure something could be done. Unfortunately it might involve harsh penalties and restrictions on illegally modified children, because plenty of parents would take 5 years in jail to give their kid super powers.

    --
    const int one = 65536; (Silvermoon, Texture.cs)
    SJW, n: "Someone I don't like, and by the way I'm a fuckwit" - AC
  50. Me am play gods! by 0xdeadbeef · · Score: 1

    The real "ethical debate" should be about whether a group of moralizing busybodies should be allowed to interfere in the reproductive choices of other people.

    Of course, it is a short debate, because the answer is "no".

    It's funny how many of our most contentious issues are actually about people fearing that someone else's (undeserving) kids will out-compete their own.

    1. Re:Me am play gods! by Anonymous Coward · · Score: 1

      Just as with vaccination, the reason you interfere with the choice of others is because a few individuals can have a radically bad influence on the rest of the group through their selfish choices.

      The concern is that by tampering with our genes (which we still have very little idea how they work overall, and do not fully understand the implications of) we can introduce horrific problems into the gene pool that may go unnoticed for many generations, long after it is too late.

      It's also working against evolution, which can impair the survivability of the species in the long term. You wanted all those essential vitamins to be self-manufactured? Sounds great, right? Well, sorry, energy requirements are now up and if famine strikes, or you even lose your high-energy western diet, your gene line is the first to die.

      Everyone leaps on the latest genetic trend? Whoops, monoculture - everyone succumbs to the same deadly disease.

      The point is that the comments thread here is itself an ongoing discussion of the ethics of the situation, only performed by amateurs with very little idea what they're talking about (normal for Slashdot).

    2. Re:Me am play gods! by djinn6 · · Score: 1

      The concern is ... we can introduce horrific problems into the gene pool that may go unnoticed for many generations, long after it is too late.

      If you notice a problem, just change it back. If the genes are easy to edit, they'll be easy to un-edit.

      It's also working against evolution, which can impair the survivability of the species in the long term. You wanted all those essential vitamins to be self-manufactured? Sounds great, right? Well, sorry, energy requirements are now up and if famine strikes, or you even lose your high-energy western diet, your gene line is the first to die.

      The only thing impairing the survivability of the species is the fact that we all live on this same rock. Famine will never kill everyone.

      Everyone leaps on the latest genetic trend? Whoops, monoculture - everyone succumbs to the same deadly disease.

      What is quarantine?

  51. Re:White Leftists Whine, China Creates Superhumans by Anonymous Coward · · Score: 1

    I would say it really doesn't matter. Having a great disparity between rich and poor is the stable state for a human government, where democracies or stable times where people have similar incomes are at best transitory points (Iran for example.)

    It might just be that human destiny is like the master/slave species like the Canopians in Piers Anthony's Cluster series. Of course, going down these thought processes, we are definitely going down the same paths that the pre-Nazis did with eugenics... but if you look at the tech industry and idols like Steve Jobs that gave $0 to any charity, you will realize that you can't eat ethics, if it makes better, stronger, smarter, healthier, longer-lived kids than the people who cannot afford it, do it. That is the modern way, and the center of secular humanism.

    Even if one follows a faith, some beliefs even say that people were made poor because they are being punished (either for a past life, or for sins of family members.) There is a philosophy from Persia of "kick a blind man. Why be kinder than God?" If you were given the ability to improve your genetic code, it is a blessing from God, so use it.

    tl;dr, ethics have no ROI. Mod your kids.

  52. Re: ill tell you by IMightB · · Score: 2

    Sounds like you need some editing yourself, if this is what you consider a thoughtful, appropriate reply.

  53. Re: White Leftists Whine, China Creates Superhuman by IMightB · · Score: 2

    While I don't entirely disagree with you, this is an extremely slippery slope to go down.... I would actually oppose you until we 100% (well as close as we can get) understand genetics. For as advanced as we are right now, we're just leaving the horse and buggy era, and its just too soon to be messing, wholesale, with human genetics.

  54. Re:It will be used for the traits that pay the mos by Xarius · · Score: 2

    CRISPR is already super cheap (in relative terms), it's extremely simple and doesn't require enormous expenditure to set up and run. economies of scale would materialise almost instantly and a minimum wage worker could afford, in a year or two, to give his kids the same advantages rich dickheads do.

    It may actually become an equaliser. The lie that we're all born with the same opportunities could be whittled down some and made real by this.

    --
    C17H21NO4
  55. Re:What the hell by Anonymous Coward · · Score: 0

    Spoken like a true child of capitalism. I bet you know the price of everything, too.

  56. Re: Create the perfect woman by IMightB · · Score: 1

    Let me guess: you're from the great lakes area and have heard of the musician Pat Dailey... https://m.youtube.com/watch?v=...

    Not my favorite version of the song, but 2/3 of the way into the song .... Is the appropriate verse.

  57. Re:White Leftists Whine, China Creates Superhumans by rickb928 · · Score: 4, Interesting

    Genomics and genetic manipulation will not result in any sort of equality.

    Initially the rich will have access, and control, and well, become richer and richer if they have their way. Inequality persists.

    Then the technology will become 'democratized', IE cheaper, and the less rich will take advantage of it.

    Finally, the much less rich will find this technology is 'given' to them to 'solve problems', mostly to do with productivity, healthcare costs, and anything annoying the regulators believe ought to be fixed.

    Along the way, much black-market stuff will happen. Gender selection will be popular. Cosmetics of course.

    Equality? No, that will never be a goal nor result of this genetic manipulation.

    --
    deleting the extra space after periods so i can stay relevant, yeah.
  58. Re:White Leftists Whine, China Creates Superhumans by rickb928 · · Score: 1

    "bill making children of artificial insemination illegitimate"

    And husbands could, no, wait for it, WILL merely adopt these children. Nullification. That was easy.

    Somehow, when a non-Leftist proposes stupid legislation, it's a criminal, offensive, morally bankrupt act. But when a Leftist proposes something equally stupid, they get a pass for caring, being correct, and generally nice people, no matter how much money and freedom THEY take in the name of whatever cause du jour they are forcing.

    Eh. the tide has turned. I shouldn't be doing this.

    --
    deleting the extra space after periods so i can stay relevant, yeah.
  59. Re:It will be used for the traits that pay the mos by rickb928 · · Score: 1

    "The best way to handle it is to only allow modifications that are available to everyone."

    Ok, you give yours away first. Thanks, bye.

    --
    deleting the extra space after periods so i can stay relevant, yeah.
  60. More nonsense from scientists by Sqreater · · Score: 1

    We (humanity) don't even know if diseases ARE diseases from evolution's viewpoint. They may simply be an evolutionary vector, a change on the way to something else. But let's fix evolution for individual humans. And how many times have we seen this cycle? They have a serious concern. They have conferences and write papers. Then they do it anyway, because it is interesting to them.

    --
    E Proelio Veritas.
  61. Re:Create the perfect woman by rickb928 · · Score: 1

    Self-motivated to labor and toil for your benefit. Not too intelligent.

    Oh, wait, let me fix that for myself. Leave them the hell alone. trying to improve women is the wrong thing, wrong way. Try improving yourself, fellow men.

    Then you will either find the woman you choose is somehow so much better, or that she is so much more desirable.

    --
    deleting the extra space after periods so i can stay relevant, yeah.
  62. These are wonders ... by dbIII · · Score: 1

    These are wonders beyond what we can conceive but the next generation will be able to learn from their four fathers.

  63. Re: White Leftists Whine, China Creates Superhuman by Oligonicella · · Score: 1

    The entire debate isn't relevant anyway. Just look at the time frame involving inception to public use of 3D printers. Same will happen here. In short order this will not be a high-tech lab activity.

  64. Better Question by Shane_Optima · · Score: 1

    Given how quickly cephalopods can breed and the lack of legal impediments concerning non-humans, I think the more pressing question is "what's the ETA for fully functional tentacle monsters?"

  65. Re:It will be used for the traits that pay the mos by Anonymous Coward · · Score: 0

    A great man, who shall not be misunderstood to have been a good one, once said: "Quantity has a quality all its own".

  66. Gattaca? by Anonymous Coward · · Score: 0

    A whole article about this and not a single mention of Gattaca. And you call yourselves nerds.

    1. Re:Gattaca? by slew · · Score: 1

      A whole article about this and not a single mention of Gattaca. And you call yourselves nerds.

      Actually, I was thinking about the eyeball lab scene from Blade Runner. Just one of many areas where the movie was better than the book Do Androids dream of Electric Sheep...

  67. Re:It will be used for the traits that pay the mos by ranton · · Score: 1

    The best way to handle it is to only allow modifications that are available to everyone, so we can create a large market for Chinese genetic conception tourism.

    People need to face facts. With a new world government mandating these laws across the globe, you cannot stop the wealthy from finding some country which will allow it. If they can afford some $500k procedure to improve their children, do you really think they cannot afford a $10k vacation to China?

    --
    -- All that is necessary for the triumph of evil is that good men do nothing. -- Edmund Burke
  68. Perhaps Ron White is wrong by flatulus · · Score: 2

    Perhaps this will lead to a fix for stupid.

  69. Re:It will be used for the traits that pay the mos by avandesande · · Score: 1

    sequencing the human genome cost 100s of thousands of dollars a decade or so ago and it is a few hundred dollars now. I don't see why gene therapy will be expensive.

    --
    love is just extroverted narcissism
  70. Re: White Leftists Whine, China Creates Superhuman by shaitand · · Score: 1

    On the contrary, this has been something you could work with $5 worth of raw material, a few dozen hours of self study, and a few hundred bucks worth of diy equipment for at least a decade now. Thanks to IP and strict agreements no share terms on that $5 worth of material plus ethical concerns has remained something that in practice will require you to be associated with a multi-million dollar organization to play at all.

  71. Re:White Leftists Whine, China Creates Superhumans by shaitand · · Score: 1

    That is a short term problem. The rich and the poor still mate and have offspring which will be poor as often as rich.

  72. I could not agree more. by bdwoolman · · Score: 1

    I really learned something from your comment. It really put some meat on the bone, Yes, for the reasons you so clearly stated, whatever the Chinese do with gene tech will not be pretty or even handed. One would hope that we can move forward with more decency and with a higher ethical standard... But move forward we must. And quickly.

    --
    "No fear. No envy. No meanness." Liam Clancy
    1. Re:I could not agree more. by slew · · Score: 1

      I really learned something from your comment. It really put some meat on the bone, Yes, for the reasons you so clearly stated, whatever the Chinese do with gene tech will not be pretty or even handed. One would hope that we can move forward with more decency and with a higher ethical standard... But move forward we must. And quickly.

      So we aren't going with the lysine contingency route then?

  73. Re:White Leftists Whine, China Creates Superhumans by Anonymous Coward · · Score: 0

    And husbands could, no, wait for it, WILL merely adopt these children.

    And you're offering to pay the $1500-$2500 for that?

    But when a Leftist proposes something equally stupid, they get a pass for caring, being correct, and generally nice people, no matter how much money and freedom THEY take in the name of whatever cause du jour they are forcing.

    At least the liberals can pretend to believe that whatever they're doing is helping somebody regardless of whether it works or whose liberties it infringes. Can you even name one person being helped by Tennessee's proposed bill? Of course because you're not a morally bankrupt hypocrite who actually is against big government and doesn't just use it as a bumper sticker, you're not going to name whatever government agency or courthouse collects that money, right?

  74. Not for Ethicists to decide by mi · · Score: 2

    It is mostly hand waving blather

    Worse. The objections are justified by ethics. As if it were unethical to want your children to be smarter, stronger, and better-looking.

    Maybe, the changes are "dangerous" from the point of view of Biology and population health. But dragging Ethics into it is utter nonsense.

    --
    In Soviet Washington the swamp drains you.
    1. Re:Not for Ethicists to decide by fox171171 · · Score: 1

      Maybe, the changes are "dangerous" from the point of view of Biology and population health. But dragging Ethics into it is utter nonsense.

      Ethics does come into play, particularly since we are beginners at this technology. Is it ethical to go ahead and create a human being designed to be smarter and stronger, and it ends up with unintended consequences because we are amateurs? Maybe the child lives in constant pain? Has missing limbs? Three eyes? And all we can say is "Whoops! You were just supposed to be smart."

      I'm pretty excited by the technology, and don't wish to stop it (I'm sure we couldn't if we wanted). I think we need to be careful, and we need to remember that our mistakes could lead to a great deal of suffering to the innocent humans we create.

      Will it be available to everyone? Or just the 0.1%? Or the military supersoldiers? Or some other country creating a "master-race"? There is a lot that could go wrong, not only with the technology itself, but also with how we use it.Certainly lots to consider. Ethics is only one small part of it.

    2. Re:Not for Ethicists to decide by mi · · Score: 1

      Maybe the child lives in constant pain? Has missing limbs? Three eyes?

      These are questions for Biology in general and Genetics in particular. Not for Ethics. And that's my point.

      Will it be available to everyone? Or just the 0.1%?

      These might be questions for Ethics, but we already have the answer: there is nothing unethical about richer people having better things. FYI, in the 19th century, flush toilet was only for the 0.1%...

      Certainly lots to consider

      Yes.

      Ethics is only one small part of it.

      No, Ethics has no part in it.

      --
      In Soviet Washington the swamp drains you.
  75. "We're only talking about fixing diseases." by jeffb+(2.718) · · Score: 1

    Of course, the most pernicious diseases are those congenital disorders of metabolism that cause you to develop the wrong skin/hair/eye color, or the wrong adult height or weight. At least, that's what the money will say.

  76. Open your eyes and look around you by alexo · · Score: 2

    The wealth distribution gap between the rich and the poor is continuously widening. What makes you think that these scientific advancements will be equally available to all members of society?

    This will lead to the inequality between the classes to become entrenched on the genetic level.

    1. Re:Open your eyes and look around you by Shane_Optima · · Score: 1
      As a poor person who possesses some modicum of awareness and proclivity for deep thought, I have quite a lot to say on the subject of wealth and class inequality, including the long list of laws that sustain the status quo... but the doom and gloom over this technology is both (mostly) wrong and pointless.

      What makes you think that these scientific advancements will be equally available to all members of society?

      For the same reason that iPhones can be found in significant numbers even amongst the poor--the economics of scale are such that, after an initial break-in period where only the rich can afford it (perhaps two decades at the absolute most, which given the gestation of humans is *far* too short for any real prejudice to emerge), the technology and infrastructure will mature to the point where it's affordable to the vast majority of the population. Also, during this initial break-in period, the improvements offered will probably be modest relative to the game changing superhuman stuff that might come much later.

      I'm not super well versed in biotech but I have observed many procedures plummet in cost once things mature (most notably genome sequencing.) Other people in this thread have talked at length about how cheap and easy this is to do in principle... it won't stay a rich persons' product for long, it really won't. It can't.

      This will lead to the inequality between the classes to become entrenched on the genetic level.

      Yeah, it's a pity rich people never have sex with the poor... oh wait.

      You realize that every single lesbian couple wanting a kid will go for the super-sperm, right? (Well, minus the particularly hardcore tofu-eaters.) It's not going to be particularly hard to get hold of. Plus a fair number of single women, plus probably even some women in committed heterosexual relationships.

      Even if none of this were true, it's still unclear what the alternative is. China *will* do it, unless there's some cultural impediment I'm unaware of here (there are cultural impediments to organ transplant too, but that hasn't stopped them from apparently harvesting them on-demand from political prisoners.) Russian millionaires will certainly do it.

      This is happening. Figure out how to deal with it. Demonizing it is head-in-sand behavior.

  77. Same problem as AI, etc. by fyngyrz · · Score: 3, Insightful

    The problem here -- and why these "ethicists" are pretty much irrelevant other than listening to themselves pontificate -- is that just like AI and a host of other things of similar nature, you can make all the rules and laws you want, but as the tech or product or service becomes readily available, people will do what they want with it, not what you want (or insist upon.)

    Can't buy pot at the corner store? Fine. Get it on the black market.
    Can't buy sex at the hotel? Fine. Get it on the black market.
    Can't get an AI that is designed to do [whatever]? Fine. Get it on the black market.
    Can't get a gene edit to to [whatever] at a doctor's office or a commercial lab? Fine. Get it on the black market.

    Where there's demand, there's provision. No way around it. Good or bad, easy or hard -- it's going to happen.

    --
    I've fallen off your lawn, and I can't get up.
    1. Re:Same problem as AI, etc. by atrex · · Score: 1

      Banning steroids and other performance enhancing drugs doesn't stop them from being used in sports whenever the person/team thinks they can get away with it. It will be the same with gene manipulation if they find ways to make it lead to smarter, stronger, faster human beings. There are plenty of wealthy individuals out there that would want every advantage for their children regardless of any ethical barriers.

    2. Re:Same problem as AI, etc. by syntotic · · Score: 1

      What they CAN, not what they WANT. Just see: Microsoft Windows #X.

  78. Re:Deport all smelly indo-chimps from by virtuosonic · · Score: 0

    I think we should start hearing the ethicists once they create something useful

    --
    http://agender.sourceforge.net/ get a free schedule tool
  79. Re:White Leftists Whine, China Creates Superhumans by rickb928 · · Score: 1

    Since I'm working on adopting a child right now I can tell you that $1500-$2500 is a low estimate for initial expenses. This will cost me $25,000 before I'm done. And the expenses of raising a child beyond that.

    But I'm not in Tennessee, nor am I adopting a child the result of anything other than a failed family.

    --
    deleting the extra space after periods so i can stay relevant, yeah.
  80. Wolf to Friendly Dog, Human to Evil CEO? by omfglearntoplay · · Score: 1

    I am willing to bet that gene editing will lead to more evil humans. Why? The rich that could afford and want to edit genes are going to want to give their kids the things they admire.

    What they admire is easy to guess regardless of decade we are in... they'll want their kids to be like them but "better", and most rich people run businesses. They'll want height, competitive drive, greed (they won't call it greed), alpha dog attitudes, and other qualities that lead to "being a better business person". And of course genderwise, muscles on guys, curves on girls. So what are you breeding?

    A whole new race of miniature psychopath CEOs that have zero empathy towards the rest of their race.

      https://www.quora.com/Why-do-p...

    http://www.forbes.com/forbes/w...

    The Wolf to Friendly dog thing is highlighted by a Russian study of wild foxes. It took a few years for the foxes to be bred into animals that look a lot like dogs... curly tails and whatnot. The genes that make the fox less mean to humans connected to genes that basically made the fox less mature and more pup like. They may have tried to breed some of that back out, but look at the TV show that goes into some detail about this.

    https://en.wikipedia.org/wiki/...

  81. We can hope by bdwoolman · · Score: 1

    Would truly superior beings be oppressive? Maybe. Perhaps what our Genetically Enhanced successors gain in intelligence they would also gain in wisdom. I think the education of such beings would be of critical importance. Public school might not be such a good idea. Cheers

    --
    "No fear. No envy. No meanness." Liam Clancy
  82. Re:White Leftists Whine, China Creates Superhumans by fox171171 · · Score: 1

    My concern with giving advantages is exasperating the resource divide between the rich and poor by adding a capability divide, such that the rich get enhancements that help them get more rich whilst the poor pool up dysfunction and mediocracy.

    I suspect at first it will only be available to the rich, but later it will become mandatory for the poor. They will be edited to be more docile, compliant, submissive, obedient.

  83. Gundam by Anonymous Coward · · Score: 0

    Reminds me of the anime Gundam Seed.
    Humanity figured out how to engineer genes and henceforth came the "Coordinators", pretty much a super human.
    A war broke out between "Naturals" and "Coordinators" because Coordinators were seen as an abomination due to man tampering with nature.

    Anyway, it's an interesting story, made me a reflect a bit on my younger years

  84. Unique Nature of webapps by rrajdev · · Score: 0
  85. Re:Deport all smelly indo-chimps from by syntotic · · Score: 1

    Let Ethicists do their own gene splicing first, then complain. Believe me, Philosophy is out. If we wipe out ourselves with gene editing, so be it! The more, the better, someone will come up with a deterrence reply or a solution. We try to regulate before knowing what is going to be regulated. You can achieve an army of clones just by having sex with different women even day, it already happened. Anyway, to see results two generations later by the end of life... unless we can make the girls grow up quicker, of course. If they can accomplish it by gene splicing, they probably deserve it. Better ENSURE standard and typical crimes like fraud, theft, misrepresentation, extortion, kidnapping be stopped before someone can claim somebody else s work in this discipline. Now, can ANYONE get me SOMEONE to turn my airplane mode OFF again so I can keep enjoying of my BT mouse and console controller for GBA/DSi ROMS? The API seems so secretive no solution in the internet can be found and NO ONE seems to be able to just code a solution, like before. A call by a stranger and your lap goes into mute, go figure...

  86. Re: It will be used for the traits that pay the mo by angel'o'sphere · · Score: 1

    Am I the only one who saw frankensteiner.fr in that URL?

    --
    Cost free eBook I read (by iBook/Kobo/Amazon/ObookO/Gutenberg etc.): "The Green Odyssey" by Philip Jose Farmer.
  87. First Use by Anonymous Coward · · Score: 0

    I'll bet the first use of this new technology will be to create a new bioweapon.