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Study Finds Probiotics 'Not As Beneficial For Gut Health As Previously Thought' (theguardian.com)

An anonymous reader quotes a report from The Guardian: The gut microbiome is the sum total of all the micro-organisms living in a person's gut, and has been shown to play a huge role in human health. New research has found probiotics -- usually taken as supplements or in foods such as yoghurt, kimchi or kefir -- can hinder a patient's gut microbiome from returning to normal after a course of antibiotics, and that different people respond to probiotics in dramatically different ways. In the first of two papers published in the journal Cell, researchers performed endoscopies and colonoscopies to sample and study the gut microbiomes of people who took antibiotics before and after probiotic consumption. Another group were given samples of their own gut microbiomes collected before consuming antibiotics. The researchers found the microbiomes of those who had taken the probiotics had suffered a "very severe disturbance." "Once the probiotics had colonized the gut, they completely inhibited the return of the indigenous microbiome which was disrupted during antibiotic treatment," said Eran Elinav, an immunologist at the Weizmann Institute of Science in Israel and lead author on the studies.

The scientists also compared the gut microbiomes of the gut intestinal tract of 25 volunteers with that of their stools. They found that stool bacteria only partially correlated with the microbiomes functioning inside their bodies. "So the fact that we all almost exclusively rely on stool in our microbiome research may not be a reliable way of studying gut microbiome health," said Elinav. In the second paper, the researchers examined the colonization and impact of probiotics on 15 people by sampling within their gastrointestinal tract. They divided the individuals into two groups: one were given a preparation made of 11 strains of very commonly used probiotics and the other were given a placebo. Of those who were given probiotics, he said, "We could group the individuals into two distinct groups: one which resisted the colonisation of the probiotics, and one in which the probiotics colonized the gut and modified the composition of the gut microbiome and the genes of the host individual."

21 of 115 comments (clear)

  1. Bitter sweet by Anonymous Coward · · Score: 3, Interesting

    Been saying this for years. I get some people have IBS but the reliance on things like yogurt is crazy.

    Fun little tip for a stomach ache - saliva. Let it build in your mouth (without water) and swallow in one gulp. Not only does it give your mouth a natural way to break down any bateria / sugar, but helps to calm your gut. Mouthwash is the nuclear option.

    So much of how your body functions comes down to diet. It's interesting they do not go into what foods were consumed.

    1. Re:Bitter sweet by omnichad · · Score: 5, Informative

      The "S" stands for syndrome, which identifies it as a collection of symptoms and not a disease. It's a diagnosis only in that there are good ways to treat the symptoms even when you don't understand the root cause fully.

  2. Don't take probiotic pills by PopeRatzo · · Score: 4, Insightful

    Don't waste your money on probiotic capsules. If you want to try to increase the amount or variety of bacteria in your guts, there are tons of delicious foods that are chock full of probiotics. Olives, pickles, fermented meats like the Italian delicacy soprasetta (which might be the tastiest thing ever invented by humans). Kimchi is also good, but it will make you smell bad, so if you're single, you might want to go easy on the kimchi.

    Also, if you use vinegar on salads, try getting some of that good cider vinegar that still has the "mother" in it. Shake the bottle and use like any other vinegar. And of course, yogurt, kefir, that kind of stuff is delicious too.

    I'm not crazy about kombucha. It's a big fad now and there are places here in California that have kombucha on tap, but it's not really to my taste. Some people swear by it. I notice that now when you buy it in the store, they ask for an ID since there's a small amount of alcohol in it.

    Also, alcohol is not really good for your gut bacteria, but there are more important things in life than gut bacteria, you know? Just eat a lot of different kinds of food and you'll end up with good gut bacteria without even trying.

    --
    You are welcome on my lawn.
    1. Re: Don't take probiotic pills by ljw1004 · · Score: 4, Insightful

      Why would you advise people on natural sources of probiotics - in response to an article which said that they're either ineffectual or actually bad?

    2. Re: Don't take probiotic pills by omnichad · · Score: 2, Interesting

      They likely contain a lot more biodiversity vs. a monoculture or handful of strains in probiotic supplements. And they would still probably be ineffectual most of the time, except after antibiotic use. This study doesn't cover any of that. Of course if you're trying to feed the microbiome you already have, eating unfermented vegetables makes more sense as they still have the complex sugars like oligosaccharides, fructans and so on that would feed it. That depends on whether you are repopulating after antibiotics or not.

    3. Re: Don't take probiotic pills by PopeRatzo · · Score: 5, Interesting

      Why would you advise people on natural sources of probiotics - in response to an article which said that they're either ineffectual or actually bad?

      Because on the high probability that this new "study" actually gets overturned by future research, I want people to know they can eat delicious healthy food.

      Remember when fats were bad? And coffee? And wine was good for you? And eggs were bad for you? And low-fat diets were good for losing weight?
      And chocolate was bad for you? Do you need me to go on? When a "study" comes out saying something is either good for you or not, you can almost set your clock another study coming around the corner saying the opposite. So eat what's good. If your grandparents ate something and lived to be 90, it probably won't be bad for you. Just don't waste money on some gelatin capsule with "live bacteria" in it when there are delicious alternatives.

      Remember the Nutrition Pyramid? The Four Food Groups? Member? Huh?

      --
      You are welcome on my lawn.
    4. Re:Don't take probiotic pills by PopeRatzo · · Score: 5, Insightful

      This is just crazy. You don't know what kind of bacteria is in this food. And most bacteria in our food are killed by the acids in our stomach.

      You're absolutely right. So the worst thing that can happen from ingesting this food is that you've just eaten something delicious that people have been eating for centuries. I'm not sure I get what part of it that is "crazy".

      I don't know if probiotics are good or bogus or simply neutral. But I knew that fermented food is good food. I buy this habanero hot sauce that is fermented in barrels and it will make you weep and praise the lord. Get you some of that whole milk yogurt and put a big spoon on some blueberries and a drop of honey, it's like dipping your snout in Aphrodite's lady parts.

      Don't pay attention to the labels. Eat what you like and don't overdo it and you'll live a nice long life and you won't need all those antibiotics because you'll be healthy.

      --
      You are welcome on my lawn.
    5. Re: Don't take probiotic pills by Zorpheus · · Score: 5, Interesting

      I once made sourdough bread myself and added more of the starter culture to the dough than you normally would, since I just had too much. It turned out to be pretty sour. But what was really interesting: when the bread got older it never grew mould as it normally does. Instead it just got even more sour over time. The environment of the dough did not permit mould to grow, even after the initial organisms were killed by baking.

    6. Re: Don't take probiotic pills by Maxo-Texas · · Score: 3, Interesting

      I've had a complete failure of my gut three times in my life. The first took months to recover naturally. The other two, I recognized and bought a bottle of "yellow" and "purple" gut bacteria, and contrary to the labels simply took one of each capsule type (they wanted you to take one daily). I recovered within 48 hours after taking the pills on those two occasions.

      So for me- it worked very well on two occasions.

      I do not consume pro-biotics on a regular basis tho I do eat yogurt about 30 days a year just for the flavor, not for the health benefits.

      --
      She was like chocolate when she drank... semi-sweet at first and then increasingly bitter.
    7. Re: Don't take probiotic pills by Zorpheus · · Score: 2

      I am talking about the probiotic yoghurt and the one with El Casei cultures. They claim to be healthy for the gut without real proof.

    8. Re: Don't take probiotic pills by Translation+Error · · Score: 2

      Even if there's evidence that probiotics can cause problems after a course of antibiotics, it doesn't necessarily follow that they should be avoided in general.

      --
      When someone says, "Any fool can see ..." they're usually exactly right.
  3. Makes sense to me. by Vegan+Cyclist · · Score: 5, Informative

    Most probiotics are a pretty small range of bacteria, and I don't know if I've ever seen anywhere that confirms these are actually the ones we want on a large scale...especially when some supplements have pretty large doses of these.

    From all the reading I've done it seems the best direction will be to focus on prebiotics, aka the foods that the microbiome thrives on, which is typically fibrous vegetable matter. Feed the good ones you've got (rather than trying to implant others), and you'll probably be better off.

  4. This study is done by morons by gurps_npc · · Score: 3, Insightful

    What idiot thinks that if you give pills of a specific biome you will get something BESIDES that specific biome???? Look, if you take probiotic pills, you are replacing your normal biome WITH the biome of the pills.

    That was the presumed GOAL of taking the pills. The fact that your biome change is the thing you were trying to do, that's why you take the pills.

    If you have a blue car, and then paint it with red paint you are an idiot if you complain that the car is no longer red.

    There are lots of good reasons to try and change your microbiome. We are pretty sure that some microbiomes cause ulcers, obesity, and even diabetes, We have suspicious about cancer, autism, autoimmune diseases, and many other things.

    We don't know much about microbiomes, we are not sure about a lot of things and it might make zero sense to take a probiotic pill. But it also might make a lot of sense.

    These studies don't answer the real question. They have nothing to do with it being beneficial or not, they just show that a change has occurred. They are talking about whether the pills change your biome, (and they do), not about whether it is a good idea to change your biome by taking the pills.

    --
    excitingthingstodo.blogspot.com
    1. Re:This study is done by morons by omnichad · · Score: 5, Informative

      Look, if you take probiotic pills, you are replacing your normal biome WITH the biome of the pills.

      The study concluded the opposite (in all cases except with antibiotic use). And the results are surprising. What it sounds like is happening is that all of the bacteria in the probiotic compete for food with the biofilm in your intestines. However, the probiotic has no way to supplant the biofilm - that's a protective layer that keeps out competing bacteria. It just starves the resident population a little bit as it passes on through. Either way, more or less none of it stays behind and it all leaves the body with your digested food.

      With antibiotic use, the biofilm dies off, but there are only a few strains in the probiotic. These compete with the remnant biofilm reserve in the appendix for recolonization and actually slow recovery. Again this is just continuing my theory based on the results of the study. And those few strains are not enough diversity to maintain your digestive health and should not be the entire makeup of your intestinal microbiome.

  5. Re:Probiotics are disgusting. by jblues · · Score: 5, Informative

    Bacteria are are naturally present in raw fruit and vegetables and naturally fermented foods, including naturally fermented bread. Most cold climate cultures relied on fermented vegetables to get them through the winter. Salt fermentation of raw vegetables allows the lactobacillus bacterias to proliferate. Almost all of the sugars are consumed, however most of the rest of nutritional profile is intact, including the vitamin C. In some cases the nutritional profile is enhanced. This is why viking sailors didn't get scurvy. I used to wonder how these past cultures survived the whole winter without vegetables. They actually didn't.

    The amount of bacteria in many fermented foods exceeds probiotics dosages. They might not be very beneficial, but they're probably not very harmful either. They certainly have an effect on the gut biome. In some cases certain strains have been shown to be beneficial, through immune system modulation, for certain conditions, such as in the natural treatment of eczma - there are efforts ongoing to commercialize on this.

    --
    If it acquires resources on instantiation like a duck, then its a shared_ptr<Duck>
  6. Re:Probiotics are disgusting. by Firethorn · · Score: 4, Interesting

    The amount of bacteria in many fermented foods exceeds probiotics dosages. They might not be very beneficial, but they're probably not very harmful either. They certainly have an effect on the gut biome. In some cases certain strains have been shown to be beneficial, through immune system modulation, for certain conditions, such as in the natural treatment of eczma - there are efforts ongoing to commercialize on this.

    I actually heard about the probiotic stuff on NPR where they were talking to a researcher. He said the exact opposite - that fermented foods were superior to many probiotic preparations such as pills because they didn't have as much bacteria, and were mixed with other materials that would help with digestion and ensuring that the consumed bacteria didn't overwhelm where they weren't supposed to.

    --
    I don't read AC A human right
  7. Re:Probiotics are disgusting. by jblues · · Score: 4, Informative

    Probiotics are bacteria. Lactobacillus is a type of bacteria. They are gram-positive, facultative anaerobic (meaning they don't need oxygen) or microaerophilic, rod-shaped, non-spore-forming bacteria. There are lots of different species of lactobacillus. These are "friendly" bacteria that normally live in our digestive, urinary, and genital systems without causing disease. They also occur in nature, for example on raw, fresh vegetables, or fermented foods like yogurt and in dietary supplements. They are generally harmless, sometimes beneficial to almost everyone.

    Perhaps on NPR they were saying the fermented foods have less noxiousbacteria than probiotic preparations. There are other kinds of bacteria, that in a person with a well functioning immune system will be harmless, but could cause problems to someone who is already ill. And then there are things like Clostridium botulinum aka botulism - comes from spoiled canned foods, that you definitely don't want to ingest. It is deadly.

    --
    If it acquires resources on instantiation like a duck, then its a shared_ptr<Duck>
  8. Re:I guess it's back to by serviscope_minor · · Score: 5, Funny

    Seriously, is anything [...] really bad for you in moderation?

    Plutonium.

    --
    SJW n. One who posts facts.
  9. This is rather confusing by butchersong · · Score: 3, Insightful

    "very severe disturbance." "Once the probiotics had colonized the gut, they completely inhibited the return of the indigenous microbiome which was disrupted during antibiotic treatment,"

    Isn't that the entire point of taking probiotics? To populate the gut microbiome with whatever you are ingesting? Who in their right mind would have theorized anything else occurring? The entire point is to get those strains of bacteria in the guts. How is that a "very severe disturbance"?

  10. How yogurt is made by DrYak · · Score: 2

    that's how yoghurt is made. Same with cheese. How did you think they were made?

    saddly some cheap industrial process are just mixing in cheap acids to accelerate the precipitation.
    you also get a firm product at the end just like with naturally occurring lactic acid, but with less waiting for the fermentation to produce those.

    but yes, the *real* one relies on fermentation.

    --
    "Sufficiently advanced satire is indistinguishable from reality." - [Tips: 1DrYakQDKCQ6y52z6QbnkxHXAocMZJE61o ]
  11. Completely normal by nospam007 · · Score: 2

    "The researchers found the microbiomes of those who had taken the probiotics had suffered a "very severe disturbance."

    A pound and a half of Sauerkraut can do that for you.