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New US Experiments Aim To Create Gene-Edited Human Embryos (npr.org)

An anonymous reader quotes a report from NPR: A scientist in New York is conducting experiments designed to modify DNA in human embryos as a step toward someday preventing inherited diseases, NPR has learned. For now, the work is confined to a laboratory. But the research, if successful, would mark another step toward turning CRISPR, a powerful form of gene editing, into a tool for medical treatment. Dieter Egli, a developmental biologist at Columbia University, says he is conducting his experiments "for research purposes." He wants to determine whether CRISPR can safely repair mutations in human embryos to prevent genetic diseases from being passed down for generations. So far, Egli has stopped any modified embryos from developing beyond one day so he can study them. "Right now we are not trying to make babies. None of these cells will go into the womb of a person," he says. But if the approach is successful, Egli would likely allow edited embryos to develop further to continue his research. Egli's research is reviewed in advance and overseen by a panel of other scientists and bioethicists at Columbia. Specifically, Egli is trying to fix one of the genetic defects that cause retinitis pigmentosa, an inherited form of blindness. "If it works, the hope is that the approach could help blind people carrying the mutation have genetically related children whose vision is normal," reports NPR.

87 comments

  1. Hmmmm yes, pure genetics by Anonymous Coward · · Score: 0

    Perhaps this is the start of a master race?

    1. Re:Hmmmm yes, pure genetics by Anonymous Coward · · Score: 0

      Mengele was a hack!

    2. Re: Hmmmm yes, pure genetics by Anonymous Coward · · Score: 0

      Whatâ(TM)s with the different letters on the edge of the swastikas? Does it make the whole thing have a better edge or what?

    3. Re:Hmmmm yes, pure genetics by Aighearach · · Score: 4, Insightful

      Purity, in the context of genetics, means very badly inbred.

    4. Re: Hmmmm yes, pure genetics by Anonymous Coward · · Score: 0

      And you would know!

    5. Re:Hmmmm yes, pure genetics by Anonymous Coward · · Score: 0

      Vhen I asked him to perfarm de bris,
      he said, "Circumcision? Heart surgery is a lot of money! What do you need quadruple amputation for?"

    6. Re: Hmmmm yes, pure genetics by Anonymous Coward · · Score: 0

      Don't know. One of the GNAA guys sent it to me because it's 10x better than the old swastikas. He also had an SS that I never was able to get to format right. The leading spaces or newlines never come out right.

      .,:codk0O' ';cldkO0l ,NMMMMMMWl .kMMMMMMM0. .0MMMMMMMk oWMMMMMMN,
                      xMMMMMMMK. ;NMMMMMMWl
                    cWMMMMMMN: .KMMMMMMMk
                  'XMMMMMMMd xMMMMMMMK. .OMMMMMMMO. cWMMMMMMN;
                oWMMMMMMX' ,XMMMMMMWo ;NMMMMMMWc ..,:c; .0MMMMMMMO. ..';:l. .KMMMMMMMW0KXWWMMN; dMMMMMMMMX0XNWMMMx
            kMMMMMMMMMMMMMMMWo :WMMMMMMMMMMMMMMM0.
          oWMMMMMMMMMMMMMMMx 'XMMMMMMMMMMMMMMMX'
      cWMMMMMMMMMMMMMMM0. .0MMMMMMMMMMMMMMMW:
      'XWNX0OxdXMMMMMMMN, xWWNKOkdOMMMMMMMMd .,.. ;NMMMMMMWl '... .OMMMMMMMO. .KMMMMMMMk oWMMMMMMX'
                    xMMMMMMMK. ;NMMMMMMWc
                  cWMMMMMMN; .KMMMMMMMx
                'XMMMMMMMo kMMMMMMMK. .0MMMMMMMO. lWMMMMMMN;
              dMMMMMMMX' ,NMMMMMMWo :WMMMMWNK: .0MMMMMWNx. .ldlc;'.. ;doc:,'.

    7. Re: Hmmmm yes, pure genetics by Anonymous Coward · · Score: 0

      What do you know?
      We will make our own race.
      With super soldiers...and super hookers!

    8. Re: Hmmmm yes, pure genetics by Anonymous Coward · · Score: 0

      Inbreding is a problem only if you transmit disease (mostly recessive or X chromosome linked). In this case, you can prevent transmission.

    9. Re: Hmmmm yes, pure genetics by Anonymous Coward · · Score: 0

      I'm waiting for the Model SW-3000 to come out. I heard it will be the new, refined swastika.

    10. Re:Hmmmm yes, pure genetics by Anonymous Coward · · Score: 0

      Inbreeding is never "very bad". It actually is the fastest and most efficient way to eliminate errors in the DNA of the parents. Child mortality will be high, but those that survive will have lower genetic load.

      If you believe inbreeding is bad, you don't understand why sexual reproduction exists - it is both to select for positive adaptions, and eliminate errors in the DNA replication process.

      Largescale breeding of distantly related parties largely increases genetic load, decreases intelligence, and decreases lifespan.

      The ideal mating groups are what existed historically - cousins.

  2. So where does society draw the line? by TuballoyThunder · · Score: 1

    Blind? Deaf? Skin color? Sexual orientation?

    1. Re: So where does society draw the line? by Anonymous Coward · · Score: 0

      Okay. Okay. Not okay. Not okay.

      Anything else?

    2. Re: So where does society draw the line? by Anonymous Coward · · Score: 0

      Redheads.

    3. Re:So where does society draw the line? by Anonymous Coward · · Score: 0

      (...) Sexual orientation?

      Only if we turn everybody into asexual people. It would be for the best, the next generation would be more focused on what matters and they can find new and better ways to responsibly produce babies for society.

    4. Re:So where does society draw the line? by Anonymous Coward · · Score: 0

      If we can make trannies with bigger gapes and thicker cocks, I'm all for it!

    5. Re:So where does society draw the line? by Gravis+Zero · · Score: 1

      So where does society draw the line?

      Since a "complex" modification is really anything more than an edit or two, most everything is far beyond our reach. No lines needs to be drawn for quite some time.

      You might as well be striking up an argument about AI person-hood because you're just invented the transistor in 1925 and are sure AI is just around the corner.

      --
      Anons need not reply. Questions end with a question mark.
    6. Re:So where does society draw the line? by mentil · · Score: 2

      You say 'line', I say 'goalpost'. In either case it'll keep being moved, and no legion of pearl-clutchers will stop that, for better or worse.

      --
      Corruption is convincing someone that the selfless ideal is the same as their selfish ideal.
    7. Re: So where does society draw the line? by mentil · · Score: 1

      There are real benefits to modifying skin melanin content/production. Don't be too quick to dismiss that.

      --
      Corruption is convincing someone that the selfless ideal is the same as their selfish ideal.
    8. Re:So where does society draw the line? by mentil · · Score: 1

      If some people can argue that a zygote counts as a person, why can't a single transistor also be?

      --
      Corruption is convincing someone that the selfless ideal is the same as their selfish ideal.
    9. Re:So where does society draw the line? by Anonymous Coward · · Score: 0

      You might as well be striking up an argument about AI person-hood because you're just invented the transistor in 1925 and are sure AI is just around the corner.

      That's 90% of award-winning science fiction and what nearly all of famous scientists spend their retirement years doing.

    10. Re: So where does society draw the line? by ShanghaiBill · · Score: 2

      Why should "society" (i.e.: government) be drawing the line?

      Why shouldn't individuals be allowed to make their own reproductive decisions?

      Keep your laws off my body.

    11. Re:So where does society draw the line? by phantomfive · · Score: 1

      A zygote has a lot more intelligence, and is a lot more complex, many orders of magnitude more complex, than a single transistor. A transistor isn't much.

      --
      "First they came for the slanderers and i said nothing."
    12. Re:So where does society draw the line? by Anonymous Coward · · Score: 0

      "No lines needs to be drawn for quite some time"
      The "lines" can be moved as the technology advances.

      "So where does society draw the line?" Who cares since society has turned into a collection of idiots who cannot even agree that "water is wet"..

    13. Re:So where does society draw the line? by Anonymous Coward · · Score: 0
    14. Re:So where does society draw the line? by Anonymous Coward · · Score: 0

      There will be no line, problem is that CRISPR is so cheap and easy there will be a lot of shady private companies doing whatever you want.

    15. Re: So where does society draw the line? by djinn6 · · Score: 2

      Technically not your body, but your kids. And yes, the government has some say because your kids' problems will eventually be society's problems.

    16. Re:So where does society draw the line? by Anonymous Coward · · Score: 0

      Cat ears.

    17. Re: So where does society draw the line? by Anonymous Coward · · Score: 0

      Why shouldn't individuals be allowed to make their own reproductive decisions?

      * https://en.wikipedia.org/wiki/The_Island_of_Doctor_Moreau

    18. Re:So where does society draw the line? by mossweb · · Score: 0

      Hmm... Crystals.... https://en.wikipedia.org/wiki/... schrodinger's transistor on/x/off alive/x/dead AI/x/NotAI x=linear

    19. Re:So where does society draw the line? by vyvepe · · Score: 1

      Eventually there will be no line. People will design their bodies whatever way they like it when the technology evolves enough.

    20. Re: So where does society draw the line? by Anonymous Coward · · Score: 0

      Don't turn off the gene that causes people to pay taxes.

    21. Re: So where does society draw the line? by Anonymous Coward · · Score: 0

      Interesting philosophy! Make everyone sterile, use CRISPR to turn off the sterility in embryos, and bring each baby to term only after it's genome is approved. Mark my words, we'll have that in 2 or 3 decades.

    22. Re: So where does society draw the line? by nospam007 · · Score: 1

      "Technically not your body, but your kids. And yes, the government has some say because your kids' problems will eventually be society's problems."

      Eventually? Jenny MaCarthy already made that happen. Every years hundreds of people die because of that bitch and her 'vaccinating cause autism' shtick.

    23. Re: So where does society draw the line? by Anonymous Coward · · Score: 0

      IKR bodily integrity is only for whores who got knocked up by some thug and need to flush the fetus out before the next round of slagging it up. Everyone else should have no say, and government should be allowed to inject whatever whenever into them. Now that sounds like a free, safe and happy society! Bodily integrity sounds like some sort of Russian propaganda (unless you're a knocked up whore with a half breed growing inside you, of course).

    24. Re: So where does society draw the line? by Anonymous Coward · · Score: 0

      This is typical circular liberal "logic."
      Government should play Mommy for adults, therefore they should be able to raise your kids, because they have to play Mommy for future adults.

    25. Re: So where does society draw the line? by Anonymous Coward · · Score: 0

      Ya, but talk about using selective breeding methods instead of CRISPR and suddenly you're literally Hitler.

    26. Re: So where does society draw the line? by edris90 · · Score: 1

      Take away the single greatest joy in life we are biologically capable of experiencing, our hard-coded happy button the orgasm? What is this make other things more important by removing everything more appealing? Its Hard enough to be happy in this complicated world.

    27. Re: So where does society draw the line? by edris90 · · Score: 1

      Selective breeding is just basic common sense. don't breed with people who have traits that you do not wish to have in your kids. Given that there are other people without those traits why take the risk? As long as you breed with is consensual .society's opinion is irrelevant

  3. I heard there are a bunch by bobstreo · · Score: 1

    of Chinese Scientists who have some experience with this currently looking for employment.

  4. Genetic defects by Anonymous Coward · · Score: 0

    My experiments with using internet porn always come up short. It certainly seems like a genetic defect to me. Will they do any research on addressing this problem? My thought is that a simple solution would be to alter human genetics to grow a third arm. Simple yet effective.

  5. You know ... by fahrbot-bot · · Score: 1

    ... there's an Emacs mode for this.

    --
    It must have been something you assimilated. . . .
  6. I don't believe a word from the medical idiots by Anonymous Coward · · Score: 0

    These are the same people who are "perplexed" by the appendix on MRIs or CT scans... this is the profession that can't even agree what we are supposed to EAT three times a day but we let them tool around the genome?

    Yeah, no thanks, fools.

    1. Re: I don't believe a word from the medical idiots by Anonymous Coward · · Score: 0

      Personally, I eat ass three times a day.

    2. Re: I don't believe a word from the medical idiots by Anonymous Coward · · Score: 0

      A/S/L?

  7. We all know the cure for this.. by Anonymous Coward · · Score: 0

    But no one wants to admit it..

    If their genetics are fuxked up (not unwanted and undesirable or pure race bs. but actually broken) , they need to be sterilized to stop it continuing, if not outright put down.

    And before you get all irate over this, I am in this category and wish someone had the kindness to put me down at birth. Instead of being the horror show I now am.
     

    1. Re: We all know the cure for this.. by Anonymous Coward · · Score: 2, Insightful

      The point is that thanks to CRISPR, we might be able to do eugenics without sterilization. Since most people with some bad genes also carry a lot of good genes, this is not only more humane, but also good for genetic diversity.

    2. Re: We all know the cure for this.. by Anonymous Coward · · Score: 0

      let's get rid of the appendix

  8. Finally by Anonymous Coward · · Score: 0

    A planet of busty blonds and bbcs

  9. Sexual orientation's more complicated than genes by rsilvergun · · Score: 1

    Hormonal levels in the womb, temperature differences, nutrients and other environmental factors can play a role. Not saying we won't work it out, but it won't be as easy as, say, curing hereditary blindness or hearing loss. Meaning we've got time to sort some other odds/ends out before we move on to that thorny issue.

    --
    Hi! I make Firefox Plug-ins. Check 'em out @ https://addons.mozilla.org/en-US/firefox/addon/youtube-mp3-podcaster/
  10. Re: I don't believe a word from the medical idiot by Anonymous Coward · · Score: 0

    msmash/slashdot editor/the cardboard box under the second street bridge

  11. G A T T A C A by Anonymous Coward · · Score: 0

    Will we create a new type of "racism?"
    Nay, nay, nay!

    1. Re:G A T T A C A by Anonymous Coward · · Score: 0

      racism is racism... there are no types.

      Humans will always find some group to hate... its part of our core programming.

  12. Someday by AndyKron · · Score: 1

    We're all gonna die! Someday

    1. Re:Someday by smoot123 · · Score: 1

      Birth is 100% fatal (well except for 7 billion exceptions but just wait).

    2. Re:Someday by Anonymous Coward · · Score: 0

      There are more people* alive today than have ever lived before. Therefore, birth is less than 50% fatal.

      *Homo Sapiens

  13. Re: I don't believe a word from the medical idio by Maelwryth · · Score: 1

    A/S/L = Age/Sex/Location last time I used it.

    --
    I reserve the write to mangle english.
  14. Hidden Danger by duke_cheetah2003 · · Score: 1, Insightful

    All the societal impacts aside, fiddling with the human genome, when we BARELY understand how this stuff works seems like a really dangerous idea.

    Who knows what sort of new problem you're introducing into our genome, that may not be expressed for a few generations?

    You think you solved some awful human condition, start doing it widespread, and 150 years down the road, we're all fucked cuz it did something unintended like made everyone sterile, or have some other much worse disability.

    1. Re:Hidden Danger by djinn6 · · Score: 2, Insightful

      A bug introduced by early 21st century technology will be trivial to fix with 22nd century technology.

    2. Re:Hidden Danger by Anonymous Coward · · Score: 0

      Insightful.

    3. Re:Hidden Danger by Anonymous Coward · · Score: 0

      How is editing DNA before birth and then extending it to an actual birth any different than doing gene therapy whereby one introduces a DNA modification in a current live person to correct for a gene defect?j

      To me doing DNA modifications is the same as gene therapy.....So as long as they are very sure to reduce as much risk as possible, then it will benefit some future generation to correct humanities DNA defects.

    4. Re:Hidden Danger by Anonymous Coward · · Score: 0

      Yes like how trivial it is to fix cancer caused by asbestos or brain damage from lead and mercury poisoning.

    5. Re:Hidden Danger by smoot123 · · Score: 1

      All the societal impacts aside, fiddling with the human genome, when we BARELY understand how this stuff works seems like a really dangerous idea.

      We understand the CRISPR mechanism in great detail. It's simple and reliable (relatively speaking). My Cal-student daughter uses CRISPR in her lab experiments. I'm astounded by this but there you are.

      What we don't really understand, and what Egli is trying to figure out, is how reliable this is in an embryo and whether it actually works to correct gene defects. I'm surprised he's doing this in human embryos instead of some other organism but I'm willing to trust he has his reasons. I personally don't know if we've shown this concept works in, say, pigs or rabbits. Or zebrafish, everyone's favorite biological model organism.

      I heard and interview with Egli. It sounds like he's proceeding the right way. He's not being secretive and he's run his experiments past various review panels ahead of time. I'm sure they've thought of all these objections already and trust he had compelling answers.

  15. Someone doesn't like this. by grep+-v+'.*'+* · · Score: 4, Informative

    as a step toward someday preventing inherited diseases

    "the hope is that the approach could help blind people carrying the mutation have genetically related children whose vision is normal"

    Very surprisingly to me, this is generally NOT an immediate accepted topic / action / result. IT'S GONE NOW -- I read it and was shocked. I immediately thought of Ender's Game book 3? where the ?antagonist? -- who had to start and follow wood grain lines until the gods were satisfied -- didn't want to be cured, but also couldn't disrespect her father, so was cured against her will.

    There was an article (actually, an opinion piece) that was (not any more!) at: https://www.pluralist.com/post....

    It said: A prominent disabilities activist spoke against the use of genetic editing to eliminate diseases from birth because it would be tantamount to a "genocide" against the culture of the disabled.

    Link. Other link Discussion

    We're talking about removal of diseases," she said. "That's forever. That's a change -- a modification -- that will be passed on to future generations. So that's actually genocide. It's a form of eugenics where certain lived experiences are seen as undesirable and unimaginable."

    ... argued that disabled people are a community unto themselves and that eliminating their conditions means erasing the potential future of their culture. She asked, "Where is the line between what society perceives to be a horrible genetic mutation and someone's culture?"

    The Eye of the Beholder

    I'm like: DO IT. And do it AGAIN just to make sure. And if you're bored, check to see if you need to do it AGAIN. If you want to be deaf, you can always stick bananas in your ears. Or your eyes. Or any other random orifices.

    --
    If the universe is someone's simulation -- does that mean the stars are just stuck pixels?
    1. Re:Someone doesn't like this. by djinn6 · · Score: 2

      I have the same response to people trying to save mosquitoes from genetically engineered extinction.

      There's 600,000 people on one side of the trolley track, a swarm of annoying bloodsuckers on the other, and we keep letting the trolley run over the people.

    2. Re:Someone doesn't like this. by Anonymous Coward · · Score: 0

      There's 600,000 people on one side of the trolley track, a swarm of annoying bloodsuckers on the other, and we keep letting the trolley run over the people.

      I am confused. What do lawyers have to do with this?

    3. Re: Someone doesn't like this. by edris90 · · Score: 1

      Well if it's culture then they are free to continue to do those things as cultures are just shared ideas and information passed down. I can continue to share those ideas. Old culture adapts and morphs overtime until eventually does not resemble anything recognizable as what their ancestors practiced and believed. It is normal for culture to come and go or metamorphosis. these are not things that should be feared but rather recognise as normal dynamics of culture

    4. Re:Someone doesn't like this. by ceoyoyo · · Score: 1

      At least with eliminating mosquitoes there's the possibility that it might have some horrible ecological effect that would be worse than leaving them alone.

      Curing genetic diseases is unlikely to have widespread negative consequences.

    5. Re:Someone doesn't like this. by djinn6 · · Score: 1

      There's over 3500 species of mosquitoes. Research is directed at removing just a few of those species that spread disease.

    6. Re:Someone doesn't like this. by ceoyoyo · · Score: 1

      You didn't say "a few species of mosquitoes that carry particular diseases". There are lots of people who would like to remove all mosquitoes, and the possibility has been studied. Also, you have to specify what you mean by "spread disease." Malaria, sure. Zika? West Nile?

      In everything from immigrants to genetically modified crops, people fail to state their positions precisely and that just invites others to argue past them.

    7. Re:Someone doesn't like this. by smoot123 · · Score: 1

      I have the same response to people trying to save mosquitoes from genetically engineered extinction.

      There's 600,000 people on one side of the trolley track, a swarm of annoying bloodsuckers on the other, and we keep letting the trolley run over the people.

      Generally speaking, I'm fine with exterminating mosquitoes, hopefully in an extremely painful way. However, we've seen time and again that when we introduce or destroy a species from an area, there are unexpected consequences. I think it behooves us to be a bit more humble before just going out with flamethrowers or gene drives.

      To be more specific, perhaps there's a way to just kill the malaria parasite without killing the mosquitoes. And perhaps there is some critter which eats the mosquitoes who we'd adversely affect. Or there's some critter who's numbers are kept in check by malaria infestations. Or there's some reason humans need the occasional malaria infection to keep our immune system from attacking us. These are just the questions I can think up. I'm sure the biologists involved can come up with a hundred better questions.

  16. Re: I don't believe a word from the medical idi by Anonymous Coward · · Score: 0

    99/tranny/slashdot

  17. US vs China by Anonymous Coward · · Score: 1

    So it's okay for US to do it, but not China...

  18. The rich will have designer babies by Anonymous Coward · · Score: 0

    Gattaca will be inevitable.

  19. Gattaca by Anonymous Coward · · Score: 0

    Here comes "Gattaca":

    * https://en.wikipedia.org/wiki/Gattaca

    if we're lucky. If not:

    * https://en.wikipedia.org/wiki/The_Island_of_Doctor_Moreau

    1. Re: Gattaca by Anonymous Coward · · Score: 1

      We should also stop developing cybernetics because of Robocop, AI because of Terminator and jewelry because of Lord of the Rings...

  20. This would be great by Anonymous Coward · · Score: 0

    If most diseases weren't related to things like age and lifestyle. Most humans already start out 'clean', so to speak, and genetic pre-dispositions can already be overcome. There really isn't a magic bullet when it comes to nature, and that's just the reality of the situation.

  21. We must not allow a genome gap by Anonymous Coward · · Score: 0

    After kicking up a fuss about china now the US is following in their footsteps. So predictable.

  22. Mammy ... by Anonymous Coward · · Score: 0

    I'm a malformed child due to the illegal CRISPR experiments ...

  23. There is no way ... by Anonymous Coward · · Score: 0

    ...that this could possibly end badly. We are human beings, after all. When have we ever taken and twisted a technology to its moist perverse extreme?

    1. Re:There is no way ... by Areyoukiddingme · · Score: 1

      When have we ever taken and twisted a technology to its moist perverse extreme?

      I see what you did there.

  24. Screw that I want by wolfheart111 · · Score: 1

    Superpowers. :)

    --
    [($)]
    1. Re:Screw that I want by smoot123 · · Score: 1

      Two words: gamma rays.

      Works every time. Except when it kills you.

  25. Keep calm. Everything is under control. by Anonymous Coward · · Score: 0

    The Chinese will demand their extradition and incarcerate these people like they deserve.