Holmes is a childhood friend of his daughter's, or daughter of his childhood friend or something like that, so he has known her all her life. I can't see how she could have been funded any other way.
Though this is america where people don't give jobs or security clearences or such to their relatives and friends.
Sorry I wasn't clear that that was my point: this is a product for people who have broadband, all of whom already have internet-connected devices. AT&T's box does nothing for such people *and* does nothing for people without broadband (a group AT&T is plainly abandoning).
I liked the combination of "...responding to... consumers' concern about the environmental impact... That means adding bubble envelopes". Those bubble envelopes are a glued sandwich of polyetheline and paper, which can't be recycled. Good job adressing environmental concerns, Amazon! I'm sure Scott Pruitt is thrilled.
Iâ(TM)m the opposite: Iâ(TM)d much rather just have a big block text so I can read it and enjoy it rather than have to move my eye all over the place to get around these pointless pictures that get in the way.
But I know not everybody is like that. I wish âoereader modeâ really was about reading and would strip all images out
Yes, you can transport Ethernet over HDMI. What a disappointment if the receiver or cable box or whatnot acted as a router. I suppose you could block the MAC from your DHCP server but how many people will know how to do this,
That seems ridiculous. It would be diametrically the opposite of the Whole Foods brand.
True. But the brand is softening due to mainstreamng of ts niche. There's a perfectly reasonable alternative scenario in which AMZN purchased infrastructure (warehouses, distribution, shops) and supply chain (a lot of the "organic" stuff is just product lines of the same multinationals like Nestle, Kellogs, Coca-Cola etc) and didn't have a high value for the brand.
Still makes the ideas of mixing stock-taking robots with customers absurd, I'm just talking about the idea that amzon wanted the brand positioning of WFM
As I understand it, venture capitalists tend to be unwilling to fund clinical trials that don't result in a patent or other exclusive rights that keep free riders from unfairly benefiting from the VC's investment.
Yep, that's how it works. And diagnostic companies manage to get funded and deal with this.
There's a lot of art in the med field about how to structure things in a way that are protectable.
Genetic variants are different from drugs. For one things, there are billions of genetic variants.
Currently the FDA is trying to apply drug validation studies to genetic variants. That's like requiring cars to have proper horse shoes.
So, umm, this is not the case. Do you have any idea how the non-ag side of the FDA actually operates?
When you go for approval you define the criteria. "All" you have to show is that you will show statically valid evidence that your claims are plausible. Sometimes the Agency wants some specific proof (e.g. they may ask that you use a specific animal to verify a specific procedure or organ consequence) or may want an additional test because they know some classes of can compounds have characteristic issues. But in general they don't dictate anything. Oh yeah, for a treatment there are outcome criteria, but you are mostly the origin of those as well.
Diagnostics are simpler to approve than devices, which tend to be simpler to approve than drugs, which to some degree are simpler than biologics. Each division has its own specialists. And the so-called "billions" of genetic cases are a red herring -- just consider the complex consequences of introducing organic compounds into the body.
Disclaimer: I am not a geneticist, and have not gone for any diagnostic approval, though I am an advisor to a couple of companies that have. But apart from my own experience in the small molecule domain, I do know most of 23&me's regulatory team socially, and we do talk about work. So I know generally what issues they face.
I have appeared before the FDA, discussing a testing protocol for a drug we were designing...when I was the CEO of a Silicon Valley VC-backed pharma company. The article even quotes a partner from NEA which is a life science investor in addition to being a tech investor.
Sure, some people try for easy wins...why not? Some people don't do their homework too -- and not just in the life sciences. And some people (looking at you, 23 & me), get the benefit of the FDA bending over backwards to try to allow them maximum freedom to experiment within the consrtraints of the law, and still don't do their homework, and cry victim when they finally have to deal with making no effort to prove the validity of their claims.
And then the article quotes one company that -- oops -- failed to do its homework.
I don't want to sound like an Apple shill, but the reason so many merchants and CC companies don't like apple pay is that it hides this info from the network and point of sale.
I'm even suspicious of one-time numbers from the CC company since that company knows who you are.
I understand the misuse but the places are culturally distinct. Even the few VCs with presence in both hire different kinds of people for their offices.
I remember talking with a taxi driver in Berlin who felt he knew the USA very well -- because he'd been to Miami six times. It's a cognitive bias I'm sure I suffer from too, but it doesn't mean it isn't worth correcting.
Resurgence in the popularity of analog photography has created demand for new and old film products alike.
Yes, from a very low number to a slightly less low number, as with vinyl audio. Counterexample: Keeble and Schuchat photography in Palo Alto (perhaps the only remaining place on the peninsula where you could get film developed or buy pro gear) just went out of business in November.
Slashdot Mirror
Holmes is a childhood friend of his daughter's, or daughter of his childhood friend or something like that, so he has known her all her life. I can't see how she could have been funded any other way.
Though this is america where people don't give jobs or security clearences or such to their relatives and friends.
Sorry I wasn't clear that that was my point: this is a product for people who have broadband, all of whom already have internet-connected devices. AT&T's box does nothing for such people *and* does nothing for people without broadband (a group AT&T is plainly abandoning).
If you already have broadband, you could just run a directv app on your existing devices or buy an inexpensive one.
Though I did get such an app (att watch tv) bundled with my phone service and itâ(TM)s terrible... so maybe their capacity to write one is limited.
I liked the combination of "...responding to ... consumers' concern about the environmental impact ... That means adding bubble envelopes". Those bubble envelopes are a glued sandwich of polyetheline and paper, which can't be recycled. Good job adressing environmental concerns, Amazon! I'm sure Scott Pruitt is thrilled.
Please bring me free dinner oh and yes, you must pay me for the privilege.
ipad.
Iâ(TM)m the opposite: Iâ(TM)d much rather just have a big block text so I can read it and enjoy it rather than have to move my eye all over the place to get around these pointless pictures that get in the way.
But I know not everybody is like that. I wish âoereader modeâ really was about reading and would strip all images out
I wouldn't want to be a beta tester for a 1st gen device with no pedigree. Maybe after a few iterations, sure.
I dunno, I happily replaced a blackberry with an original iphone shortly after launch, and used it for three years.
And to be fair, Andy did found Danger and Android, so there's some pedigree there.
Yes, you can transport Ethernet over HDMI. What a disappointment if the receiver or cable box or whatnot acted as a router. I suppose you could block the MAC from your DHCP server but how many people will know how to do this,
Just don't connect the TV itself to your LAN.
That seems ridiculous. It would be diametrically the opposite of the Whole Foods brand.
True. But the brand is softening due to mainstreamng of ts niche. There's a perfectly reasonable alternative scenario in which AMZN purchased infrastructure (warehouses, distribution, shops) and supply chain (a lot of the "organic" stuff is just product lines of the same multinationals like Nestle, Kellogs, Coca-Cola etc) and didn't have a high value for the brand.
Still makes the ideas of mixing stock-taking robots with customers absurd, I'm just talking about the idea that amzon wanted the brand positioning of WFM
Ha ha, had to look that one up!
They are no longer considered the worst?? Wow.
Slashdot suggest the "related" links "Donald Trump Wins US Presidency" -- must be thinking of dissatisfaction rankings.
As I understand it, venture capitalists tend to be unwilling to fund clinical trials that don't result in a patent or other exclusive rights that keep free riders from unfairly benefiting from the VC's investment.
Yep, that's how it works. And diagnostic companies manage to get funded and deal with this.
There's a lot of art in the med field about how to structure things in a way that are protectable.
Genetic variants are different from drugs. For one things, there are billions of genetic variants.
Currently the FDA is trying to apply drug validation studies to genetic variants. That's like requiring cars to have proper horse shoes.
So, umm, this is not the case. Do you have any idea how the non-ag side of the FDA actually operates?
When you go for approval you define the criteria. "All" you have to show is that you will show statically valid evidence that your claims are plausible. Sometimes the Agency wants some specific proof (e.g. they may ask that you use a specific animal to verify a specific procedure or organ consequence) or may want an additional test because they know some classes of can compounds have characteristic issues. But in general they don't dictate anything. Oh yeah, for a treatment there are outcome criteria, but you are mostly the origin of those as well.
Diagnostics are simpler to approve than devices, which tend to be simpler to approve than drugs, which to some degree are simpler than biologics. Each division has its own specialists. And the so-called "billions" of genetic cases are a red herring -- just consider the complex consequences of introducing organic compounds into the body.
Disclaimer: I am not a geneticist, and have not gone for any diagnostic approval, though I am an advisor to a couple of companies that have. But apart from my own experience in the small molecule domain, I do know most of 23&me's regulatory team socially, and we do talk about work. So I know generally what issues they face.
Typically life science startups use, you know, VC money to pay for such proof. 23&me just couldn't be bothered.
I have appeared before the FDA, discussing a testing protocol for a drug we were designing...when I was the CEO of a Silicon Valley VC-backed pharma company. The article even quotes a partner from NEA which is a life science investor in addition to being a tech investor.
Sure, some people try for easy wins...why not? Some people don't do their homework too -- and not just in the life sciences. And some people (looking at you, 23 & me), get the benefit of the FDA bending over backwards to try to allow them maximum freedom to experiment within the consrtraints of the law, and still don't do their homework, and cry victim when they finally have to deal with making no effort to prove the validity of their claims.
And then the article quotes one company that -- oops -- failed to do its homework.
I don't want to sound like an Apple shill, but the reason so many merchants and CC companies don't like apple pay is that it hides this info from the network and point of sale.
I'm even suspicious of one-time numbers from the CC company since that company knows who you are.
The US should be stealing rocket secrets from the russians!
To be fair, "building" a tower PC is just snapping together lego bricks as well. It's all about your choice of brick.
Apart from FB I pretty much only use RSS. Most sites still support it.
And the fact that FB doesn't is annoying and discourages me from visiting the site.
I understand the misuse but the places are culturally distinct. Even the few VCs with presence in both hire different kinds of people for their offices.
I remember talking with a taxi driver in Berlin who felt he knew the USA very well -- because he'd been to Miami six times. It's a cognitive bias I'm sure I suffer from too, but it doesn't mean it isn't worth correcting.
Uber is in San Francisco, not in the Valley.
Resurgence in the popularity of analog photography has created demand for new and old film products alike.
Yes, from a very low number to a slightly less low number, as with vinyl audio. Counterexample: Keeble and Schuchat photography in Palo Alto (perhaps the only remaining place on the peninsula where you could get film developed or buy pro gear) just went out of business in November.
I'm only half Asian, and it's the south kind. So pray I'm ok.
Err, except...my mum grew up speaking Chinese as a kid. Crap!
Mr Bannon I your rules unclear. Am I human or not?