I don't think they're very concerned with easily-divisible numbers—4*7-day months and 13-month years! At least the crazy Soviet calendar reform from the thirties prioritized getting rid of 7-day weeks.
It's not about whether the game is fixed or not, it's about the business's management decisions. Lots of people won't buy EA games, for example, regardless of the quality of the title itself, because of the business's conduct in the past. The simple act of shipping a fixed game doesn't equate to the necessary cultural shift from the developer that would merit returning to the game. It's not as if they've gotten rid of Bobby Kotick as the head of Activision Blizzard, or said they'd commit to a long-term fan-driven model across their titles. It's essentially a boycott.
On top of that, we're talking about rewarding them with more money for what is, at its heart, an old product with some refreshes. Expansion packs and other forms of non-free DLC are only really effective at drawing in consumers when the base product has something the player wants to continue. Many people (myself included) got sick of the repetitive, imbalanced structure of the game a year and a half ago, when it first came out, and we have no desire to relive those memories or anything tightly associated with them. D3 had a breathtakingly uncompelling story; the adventure RPG equivalent of a cookie-cutter save-the-cat blockbuster, only without any character development whatsoever. (Unless you can think of a game with a lamer ending cutscene?) Even without the auction house, crazy elite monsters, terrible loot rates, failure to learn from competitors and clones like the Torchlight and Dungeon Siege series, the total lack of character personalization, and the extensive balance issues, I think the exploitative, sequelitis-infested anti-plot would be enough to keep people away from any continuation of the franchise.
I believe the obvious message is "the bridges are burnt," not "we want more crappy games." Publishers may be incredibly, unbelievably stupid, but they are stateful enough to know when they've killed brand trust. It is one of the few things they are indoctrinated in, since they are little more than marketers run amok.
(Sure, but PacBio in particular is quite new on the market still. Three years ago they were borderline vaporware!)
And, yeah, most serious sequencing projects I've seen do use a mixture of methods, particularly 454 stuff. But I'm sure they'll switch to IonTorrent and PacBio as opportunities allow.
You're right, it's not an entirely ubiquitous phenomenon. But amongst the plants that do have large, repetitive genomes, fine-grained epigenetics and averaged-out mutations tend to be the primary benefits, IIRC.
The hardware platform of choice is a matter of availability. Here is a map of where most/all of the NGS platforms are in the world; Illumina sequencers are the most common amongst the newer systems.
63x total coverage with from Illumina hardware using a mixture of paired-end libraries, ranging from 200 bp to a whopping 40 Kbp. I'm pretty sure that's sufficient information to estimate the number of large-scale repetitions. Sequencing projects of species for which there is no good relative to scaffold against are typically much more rigorous than what you'd see in cancer research.
While the set of large-genomed organisms does include some very sophisticated trees and flowers, it also includes several species of amoeba... so I wouldn't panic just yet.
All a big genome really means for certain is that you're good enough at finding food that you can support it. The substance is a lot more important—some species of shrimp, for example, have 88 or 92 chromosomes, but they're mostly redundant duplicates. Wheat has five copies of every chromosome, too.
Plants tend to have large genomes because they reproduce so rapidly—a field of corn has enough offspring every season to mutate every nucleotide in the whole kit and kaboodle at least once, and because they have very static, slow existences, they can afford to tune themselves very well to their environments. That's what the genes and duplicates are for—giving the plant very fine-grained control over things like how it prepares for the next season based on the weather from the last one.
Inadvisable—much of wood itself (not the bark, the structural stuff underneath) is dead at functional maturity. Trees are just skin and bones! (And plumbing. And really crazy hair. And roots. And sometimes genitals.)
Ah, okay. It wasn't even a touch phone; you had to scroll/jump through selectable objects, press the "go" button, and then choose the appropriate action from a numeric menu that popped up.
I used to have a candybar feature-phone (a cheap Huawei) that ran Qualcomm BREW. I guess it's possible they licensed the patent in question, but it did have blue, underlined phone numbers. (Any number, in fact. It was not a smart phone.)
I think the real mistake is that TFA thinks Valve cares about the success of the Steam box; there's no content that you can't get without paying Valve for hardware, so the idea of a Steam box becoming their main business is utterly preposterous.
I was about to post this! 2.0 was called 1.4 while it was in development, then someone pointed out that all the other operating systems had bumped their versioning up higher already, so they changed it. 1.5 was never more than a footnote on a roadmap.
In meteorology, a butt is a visible mass of liquid droplets or frozen crystals made of water or various chemicals suspended in the atmosphere above the surface of a planetary body.[1] These suspended particles are also known as aerosols and are studied in the butt physics branch of meteorology.
...if we're getting technical we retired the maple leaves a couple of years ago. Of course, I still have a jar of them... maybe I can secretly pawn them off on hapless Americans the next time I travel south of the border.
You may have me on the RNA gene count. ENCODE ruins all the best glib flippancies!
By cumulative time I meant the following: while each strain of bacteria has had the standard 3.5 Gya to evolve, there are many strains. Since every genome experiences this passage of time separately, this gives them a significant advantage in developing symbiotic and commensal relationships. (And, of course, they can test new mutations much more quickly.)
The rest, is, of course, reality; obviously the host can survive without its bacteria, and provides almost all of the colony's total functions. (And as a matter of fact, I'm studying such a minimal mouse gut flora at the moment.) I really just wanted to emphasize how significant microbes are from an ecological diversity standpoint, which was the context.
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I don't think they're very concerned with easily-divisible numbers—4*7-day months and 13-month years! At least the crazy Soviet calendar reform from the thirties prioritized getting rid of 7-day weeks.
After the humans rejected it, they had to rebrand to reach a wider audience.
It's not about whether the game is fixed or not, it's about the business's management decisions. Lots of people won't buy EA games, for example, regardless of the quality of the title itself, because of the business's conduct in the past. The simple act of shipping a fixed game doesn't equate to the necessary cultural shift from the developer that would merit returning to the game. It's not as if they've gotten rid of Bobby Kotick as the head of Activision Blizzard, or said they'd commit to a long-term fan-driven model across their titles. It's essentially a boycott.
On top of that, we're talking about rewarding them with more money for what is, at its heart, an old product with some refreshes. Expansion packs and other forms of non-free DLC are only really effective at drawing in consumers when the base product has something the player wants to continue. Many people (myself included) got sick of the repetitive, imbalanced structure of the game a year and a half ago, when it first came out, and we have no desire to relive those memories or anything tightly associated with them. D3 had a breathtakingly uncompelling story; the adventure RPG equivalent of a cookie-cutter save-the-cat blockbuster, only without any character development whatsoever. (Unless you can think of a game with a lamer ending cutscene?) Even without the auction house, crazy elite monsters, terrible loot rates, failure to learn from competitors and clones like the Torchlight and Dungeon Siege series, the total lack of character personalization, and the extensive balance issues, I think the exploitative, sequelitis-infested anti-plot would be enough to keep people away from any continuation of the franchise.
I believe the obvious message is "the bridges are burnt," not "we want more crappy games." Publishers may be incredibly, unbelievably stupid, but they are stateful enough to know when they've killed brand trust. It is one of the few things they are indoctrinated in, since they are little more than marketers run amok.
(Sure, but PacBio in particular is quite new on the market still. Three years ago they were borderline vaporware!)
And, yeah, most serious sequencing projects I've seen do use a mixture of methods, particularly 454 stuff. But I'm sure they'll switch to IonTorrent and PacBio as opportunities allow.
You're right, it's not an entirely ubiquitous phenomenon. But amongst the plants that do have large, repetitive genomes, fine-grained epigenetics and averaged-out mutations tend to be the primary benefits, IIRC.
The hardware platform of choice is a matter of availability. Here is a map of where most/all of the NGS platforms are in the world; Illumina sequencers are the most common amongst the newer systems.
63x total coverage with from Illumina hardware using a mixture of paired-end libraries, ranging from 200 bp to a whopping 40 Kbp. I'm pretty sure that's sufficient information to estimate the number of large-scale repetitions. Sequencing projects of species for which there is no good relative to scaffold against are typically much more rigorous than what you'd see in cancer research.
...perhaps your hatred towards trees has something to do with these auditory hallucinations?
Yes. All old things are superior. Like typewriters, glaciers, and expired milk.
While the set of large-genomed organisms does include some very sophisticated trees and flowers, it also includes several species of amoeba... so I wouldn't panic just yet.
All a big genome really means for certain is that you're good enough at finding food that you can support it. The substance is a lot more important—some species of shrimp, for example, have 88 or 92 chromosomes, but they're mostly redundant duplicates. Wheat has five copies of every chromosome, too.
Plants tend to have large genomes because they reproduce so rapidly—a field of corn has enough offspring every season to mutate every nucleotide in the whole kit and kaboodle at least once, and because they have very static, slow existences, they can afford to tune themselves very well to their environments. That's what the genes and duplicates are for—giving the plant very fine-grained control over things like how it prepares for the next season based on the weather from the last one.
Inadvisable—much of wood itself (not the bark, the structural stuff underneath) is dead at functional maturity. Trees are just skin and bones! (And plumbing. And really crazy hair. And roots. And sometimes genitals.)
You know it's a problem when...
Ah, okay. It wasn't even a touch phone; you had to scroll/jump through selectable objects, press the "go" button, and then choose the appropriate action from a numeric menu that popped up.
I used to have a candybar feature-phone (a cheap Huawei) that ran Qualcomm BREW. I guess it's possible they licensed the patent in question, but it did have blue, underlined phone numbers. (Any number, in fact. It was not a smart phone.)
I believe the relevant quotation is "the best thing about STDs is that there are so many to choose from."
I think the real mistake is that TFA thinks Valve cares about the success of the Steam box; there's no content that you can't get without paying Valve for hardware, so the idea of a Steam box becoming their main business is utterly preposterous.
I was about to post this! 2.0 was called 1.4 while it was in development, then someone pointed out that all the other operating systems had bumped their versioning up higher already, so they changed it. 1.5 was never more than a footnote on a roadmap.
Speaking of realtime raytracing... (Say hello to your new god.)
The source for this figure is Richard Garriott, not IEEE. Plenty of people are IEEE members! (My cat's an IEEE member!)
I guess this goes to prove that great old chestnut—linear regression is never wrong, for very small amounts of never and asymptotic amounts of wrong.
The founder of WhatsApp, which was just bought by Facebook. Sorry, Mario, but your stereotype is in another castle.
In meteorology, a butt is a visible mass of liquid droplets or frozen crystals made of water or various chemicals suspended in the atmosphere above the surface of a planetary body.[1] These suspended particles are also known as aerosols and are studied in the butt physics branch of meteorology.
I can see forever...
Well, it's mostly zinc and other things. But yes, that's why we stopped making them!
...if we're getting technical we retired the maple leaves a couple of years ago. Of course, I still have a jar of them... maybe I can secretly pawn them off on hapless Americans the next time I travel south of the border.
You may have me on the RNA gene count. ENCODE ruins all the best glib flippancies!
By cumulative time I meant the following: while each strain of bacteria has had the standard 3.5 Gya to evolve, there are many strains. Since every genome experiences this passage of time separately, this gives them a significant advantage in developing symbiotic and commensal relationships. (And, of course, they can test new mutations much more quickly.)
The rest, is, of course, reality; obviously the host can survive without its bacteria, and provides almost all of the colony's total functions. (And as a matter of fact, I'm studying such a minimal mouse gut flora at the moment.) I really just wanted to emphasize how significant microbes are from an ecological diversity standpoint, which was the context.