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User: Doubting+Sapien

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  1. Re:This is FUD on Genomics Impact On US Economy Approaches $1 Trillion · · Score: 1

    Sir, what are your credentials? Instead of making unfounded assumptions about your Interlocutor behind the shield of an anonymous coward, would you care to comment substantively on the subject at hand? I was prepared to rebut GP, but I'd like to hear what you have to say first.

  2. Re:This is FUD on Genomics Impact On US Economy Approaches $1 Trillion · · Score: 1

    I disagree vehemently with GP as he/she is obviously clueless about the subject matter. However, I also take issue with the implication of your snippy reply that crops are somehow divorced from or not associated with progress in genomic research. I assure you, agriculture has not been left behind by recent technological innovations in this area. Many of the underlying tools and techniques jump started by the HGP is routinely used by the research arm of the USDA in the interest of the American public. During a 10 month stint at the Western Regional Research Center in Albany CA, I provided lab support for a protein chemist who studied the nature of food allergens as part of an effort to increase accessibility of nutrition to those with food allergies. For my boss, bioinformatic tools were part of his routine. For me, many of the genomic databases became my friends. Scores of molecular biology experiments I was performing couldn't be done without checking libraries or catalogs such as those at NCBI established in the wake of the HGP. A rising tide raises all boats. We may not have worked directly with the human genome, but we're all beneficiaries just the same.

  3. Re:And who's brain will it model? on Why We Should Build a Supercomputer Replica of the Human Brain · · Score: 2

    A pestilent child will bo lobbing antrax, smallpox, and/or ebola, not nukes. Get your WMD straight.

  4. Been there, done that? on Genetically Modified Plants To Produce Natural Lighting · · Score: 1

    An illuminated bush? Didn't Moses come across one of those already? If I were a Christian of the conservative variety, I would be a bit upset about some crazy scientists trying to play God. As if those pretentious molecular biologist aren't arrogant enough stealing the name of such a shady character for something as beautiful as the warm soft glow of summer evening fireflies.

  5. Re:Sustainable? on Genetically Modified Plants To Produce Natural Lighting · · Score: 1

    The solution to pollution is dilution. - with apologies to Dr. Loh.

  6. Re: One option on Space Junk 'Cleaning' Missions Urgently Needed · · Score: 1

    It is a practical reality that everything in LEO is subjected to some degree of atmospheric drag. Even the Hubble Space Telescope, at a normal altitude almost twice that of the ISS will succumb to the ocassional collision with gas particles in the thermosphere. We happen to be entering the solar maximum which should heat and expand the atmosphere, exacerbating the effect. I recall this was the reason America lost the first Skylab station. The idea of bringing the atmosphere up to the orbiting debris instead of waiting for the orbit to decay is an elegant solution. Especially for large debris fields where for example the fragments of a destroyed satellite still pretty much share the same orbit. You would maneuver a de-orbiting tanker traveling in the exact opposite direction, release a gas cloud that will collide headon with the target. Each gas particle will slow it down and lower it's altitude, sending it on its way into the thicker lower atmosphere. The gas itself would pose little hazard, most likely dissipating harmlessly. I think the biggest drawback may be that it probably wouldn't be very cost effective unless you can de-orbit multiple targets at once. In the case of stray small objects that are not trackable by radar, you simply don't know.

  7. Re: Make him run the Marathon on Police Capture Second Marathon Bombing Suspect in Watertown, Mass. · · Score: 5, Informative

    Guess who's presecuting? I'm watching the live stream from ABCnews and who should I see muscle her way in front of the mic but Carmen Ortiz. Yep, the one of Aaron Swartz fame. God! It would be such a travesty if she should escape responsibility for bullying Aaron by riding the political prestige to be had from punishing this nut job bomber.

  8. Re: Oh god, please die in a fire right now on Why Do Pathogen Researchers Face Less Scrutiny Than Nuclear Scientists? · · Score: 1

    I think the proposed usage was more of a "I want to destroy all of civilization by poisoning schoolchildren's lunchmeat" scenario than a targeted weapon.

    I'm sorry for coming a bit late to the discussion. Who's proposal? It seems to me that a Kill-every-living-human/WMD-type device that takes months to years to take effect in a statistically small proportion of the exposed target population wouldn't be a very good way to achieve any kind of military or political objective in any sensible way. If on the other hand, you are a non-state actor trying to spread terror....I'll give you that, maybe. But still, there are no historic precedence to my knowledge of any extremist groups declaring to the world: "give us what we want or we will give you brain cooties". True, symptoms of fevers/bleeding/malaise of things like bird flu makes for dramatic visuals in the same way conveyed by WWI photos of soldiers blinded by mustard gas. In contrast, aside from the scary name of Mad Cow Disease, how many in the general public can identify the symptoms of vCJD much less know what it is? Put it another way, Do you think a terrorist would consider it a good idea to weaponize HIV? Similar in a lot of way - certainly easier to get and transmit, but just not practical from a common sense perspective.

    This is a totally different scenario from normal warfare, for which an unmodified form of the disease vector would do just fine.

    Exactly! In unmodified form, the disease vector is terribly inefficient - being statistically significant enough infection-wise to make your target sit up and take notice, but otherwise doesn't nearly approach the virulence that true pestilences of the past have cause death and destruction among the masses. It really isn't going to kill very many people. I guess what I am trying to say is, no matter how you cut it, prions - as we currently understand them - do not have the qualities of a good biological weapon regardless of what kind of war you are trying to fight with it. I would assert thus, that given the slow acting nature and generally vague symptoms (which can easily be mistaken for other neurological issues in the absence of post-mortem histological analysis), the only appropriate role for prions as a weapon of some sort is along the lines of some kind of assassination tool. That is, if other short comings can be addressed.

    Speaking generally, I would guess that the period before symptoms manifest on a given prion is unmodifiable, and is directly linked to that protein's role in the organism.

    Last I was aware, no one has yet divined the role played by PrP in living organisms. (It must be important though because the sucker is highly conserved across many species.) It has been a while since I've kept up with this stuff, so it is entirely possible that something within the last few months has been published that can be used to put numbers on this thing. However, The matter of symptoms can be really tricky to pin down. We've made great strides in illuminating many aspects of prion molecular biology, but not nearly enough to say we truly comprehend disease pathology. To complicate matters further, the brain is an incredibly resilient organ capable of taking quit a bit of abuse by adapting and compensating around damage. It may very well be the reason why symptoms take so long to appear is because victims brains are actively rewiring around parts damaged by plaque formation. I don't know if plasticity is something that has yet been quantified and/or standardized across all people. But given the range of brains, even in a place like slashdot, there are different levels of suceptability. I could very well be wrong, but I think it is premature to be asserting any kind of symptom time frame in association with a protein function that still isn't clear at all. From a strictly experimental perspective, however, I am optimistic analytic tools and techniques can be applied with further

  9. Re: Oh god, please die in a fire right now on Why Do Pathogen Researchers Face Less Scrutiny Than Nuclear Scientists? · · Score: 3, Interesting

    So far diagnosis of prion infections can only be reliably done using post-mortem detection of PrP, which is too late in most cases. The incubation period of most prion disease, measured in months and years, makes it a very poor bio-weapon candidate. While the argument can be made that military research can make progress toward that end, the practical reality is that it is still a not very well understood disorder and a lot of basic research is still needed despite intense and public scrutiny (for obvious reasons) from the agricultural sector of developed nations. Treatment options at the moment are virtually non-existent. Containment and culling to halt the spread of infection is still the order of the day in most agro scenarios. But this has been difficult where the infection exists in wild populations. Studies from a Colorado wildlife research facility where chronic wasting disease is endemic in local elks and deers have shown that prion infections can persist dispite conventional cleaning and sterilization methods. Other research shows that livestock to human transmission are not the only cross-species cases with examples being observed in minks from fur farms and guinea pigs in the laboratory also being suceptable. Such realities have resulted in hunters and recipients of venison from road kill being publicly cautioned from consuming the meat of animals from area known to have infected populations. There are a few efforts in very early experimental stages, but owing to the still very immature understanding of prions in general, it is still effectively a fatal disease with know cure/treatment options in human.

  10. Re:I wouldn't shed a tear on Russian Cyber Criminal Unmasked As Creator of "Most Successful" Apple Malware · · Score: 1

    Well, that wouldn't be nearly as cool as assembling a posse of nerd Avengers and publicly humiliate the damn bastard in the most awesomely creative way possible. The guilty should live if for no other reason than to suffer the ridicule and retribution of those who've been harmed by said malware.

  11. treatment might be worse than the cure on Programming Immune Cells To Treat Disease · · Score: 2

    Depending on the type of cancer this therapeutic approach is attempted on, the patient may experience the same symptoms as either a severe but localized or broad, systemic infection. Even if you are going to train the immune system to go after cancerous tumor cells, it will treat the target in the same way (using the same biochemical weapons) as a dangerous pathogen. History has taught us that the immune response itself can be more destructive than what triggered that response in the first place. If this isn't done correctly, you can easily have a case where the cancer patient experiences a positive feedback loop where the immune system overshoots the intended treatment goal and kills the patient.

  12. Re:How is this insightful? on Mosquitoes Beginning To Ignore DEET Repellent · · Score: 3, Informative

    I would go so far as to even say GP is wrong. The article describes how experiments show the mosquito's olfactory system appears to loose sensitivity to DEET after the first exposure. There is no supporting evidence that conclusively points to this being due to evolutionary change. A more appropriate characterization is simply that the insect's nervous system is being down-regulated in responsiveness to this particular chemical. In other words, the mosquito adapts by learning to ignore some noxious gunk in order to get a blood meal. If such is the case, the insect is simply showing that it can be conditioned with the right stimuli. This is neural-plasticity, not evolution.

  13. No, let them be on Missouri Legislation Redefines Science, Pushes Intelligent Design · · Score: 1

    An open letter

    Dear Citizens of Missouri,

    We support your efforts to take science education in your state into a brave new world. Science is an ever changing, ever advancing quest. However, not everything in science ought to be about science. For we must recognize the practical reality that science serves human civilization. And in today's global community, the American nation faces a crisis in which we must as loyal patriots reaffirm our nation's position at the forefront of civilization. We can not afford to continue outsourcing, exporting, abandoning, or otherwise ceding economic and social opportunities to less advanced parts of the world. Therefore it is imperative that we begin building and nurturing a domestic underclass to which we can bequeath unskilled labor and civil malcontent ^H^H^H^H^H^H^H^H^H^H diversity. Through the fire of conflict that your state endured during our nation's bloody adolescence, you have demonstrated an admirable ability to endure hardship and be resilient. We should all be fortunate, that you have taken the bold step of engaging in this new social experiment where the idea that state-directed education can be used to further the socio-political goals of our nation with tangible socio-economic effects.

    Let's face it: If we are to stem the hordes of illegal residents taking away job opportunities from real Americans, we must have enough Americans sufficiently educated to be able to compete for those appropriate jobs that do not require an over-abundance of schooling based on excessive and unnecessary critical thinking. A workforce thus educated under your new legislations should be expected to also considerably lighten the load on social services such as health care that is riddled with exorbitant expenses based on medical practices founded on unproven Darwinian principles. Under ID-inspired health care, we are, by design, perfect and thus require no treatment. Imagine the savings we can achieve for a government that is already burdened by entitlement programs our children can not afford!

    Ages hence, when historians look back upon our era, the state of Missouri will be held up as a shining example of the pioneering American spirit that blazed a new trail for intellectual courage and social freedom. You will be remembered as the brave souls who cast aside the shackles of conformity and not only challenged, but prevailed against the stifling madness of old tradition. The multitudes, Missourians and non-Missourians alike, will remember with gratitude the legacy you have left them.

    yours truly, the mob-ocracy.

  14. branch out on Ask Slashdot: Programming / IT Jobs For Older, Retrained Workers? · · Score: 1

    You should seriously consider the wide-spread sentiments here about broadening your options. Your wealth of experience is your greatest asset here. I would recommend to you some writing done by NPR reporter Adam Davidson on the current and future state of American Manufacturing.

    http://www.theatlantic.com/magazine/archive/2012/01/making-it-in-america/308844/

    http://www.npr.org/2012/02/02/146297224/the-future-of-americas-manufacturing-jobs

    Basically, Adam makes the case that while low skilled, labor intensive work has gone overseas, the American economy still has a lot of opportunities for qualified workers to fill less manual but highly skilled positions in advanced manufacturing. Your work history and familiarity with industrial control stuff positions you nicely to enter the job market he writes about. You didn't mention where you live (and presumably where you'd be job-hunting) however. That may play a significant factor in available opportunities for you.

  15. Re:This is why I love science. on Dung Beetles Navigate By the Milky Way; Pigeons Tune In To Magnetism · · Score: 2
    from the article:

    The experiment was conducted both outdoors under the night sky, and inside a planetarium where researchers could manipulate the starlight and hone in on the specific cues that the dung beetles were using.

    Better trolling next time.

  16. Re:Great idea, but in Tennessee?????? on Star Wars Fans Plan Full-Size Millennium Falcon Replica · · Score: 1

    Despite my cheeky comment which set off this little flame war, I happen to identify more with rural folks myself. Before my family came to the US, my father was a vet serving a multitude of local farms. I grew up surrounded by Holstein dairy cows, pig pens, and rice patties. I'm sorry such a throwaway comment was perceived as a slight against people of rural extraction. I have read the other comments of GP and mostly sympathize with his views. I, myself, have nothing against accents as all other members of my family were too old when we came to the US to learn to speak English without an accent. Trust me, I know what it feels like to be stereotyped by virtue of where one calls home. As a high school student, I studied one summer at Cornell in Ithaca, New York. Apparently, high schoolers from other parts of the country knows of San Francisco only as the "Gay Capital of the World". For what it is worth, my real beef isn't with rural vs urban - my problem is with religious fundamentalism vs. science (which i will broadly include science fiction here) literacy.

  17. Great idea, but in Tennessee?????? on Star Wars Fans Plan Full-Size Millennium Falcon Replica · · Score: 2, Funny

    Those padawans better learn quick how to build their own light sabers when the hillbilly fundamentalists mass at the gates with pitchforks in hand.

  18. Re:Uh huh. on Research Suggests Apes and Humans Separated By a Single Gene · · Score: 1

    But most are separated by more. I find the featured article to be overtly sensationalist. Excerpts from a wonderful talk by Ken Miller on the Dover ID trial should put things in perspective: http://www.youtube.com/watch?v=zi8FfMBYCkk The fusion of chromosome #2 Dr. Miller alluded to is arguably *much* more significant than any single gene alleged in the article. I don't object to this submission as "news for nerds, stuff that matters." But jokes aside, we need much better QA for science writing in general.

  19. Re:Uplift on Research Suggests Apes and Humans Separated By a Single Gene · · Score: 1

    Where have you been? For a long time already, men have had their hands in their jeans, fiddling with themselves. Whether or not that makes you a monkey is a point of disagreement among individuals of different cultural persuasions.

  20. Re:I hope you aren't over 45 on Artificial Wombs In the Near Future? · · Score: 3, Funny

    There is no compelling contextual evidence for the age or gender of the original poster. For all we know, sexconker might very well be a young girl with a geeky streak who happens to like gourmet ice cream and pretty boys with good pipes. I sang baritone in school. An i've been told i clean up well. Anyone in SF bay area interested in starting an a Capella group? We can call ourselves "Super Cache", or maybe go with "Beowulf". What kind of name is likely to attract the attention of the geek girl among /.ers? I know! "The GNU Directions"!

  21. Re:Slashvertisement? on Elon Musk Will Usher In the Era of Electric Cars · · Score: 1

    I heard it was the other way around. SHE divorced HIM because he was too wrapped up in running his business to bother being much of a husband.

  22. Re:Signal isn't chaning, the noise floor is on Ask Slashdot: Why Does Wireless Gear Degrade Over Time? · · Score: 1

    Simple way to test that. Record/measure signal integrity in known EM noisy and EM quiet environments with the same hardware. I'd be genuinely curious if anyone knows of any such benchmarking to test equipment quality.

  23. Re:Can't read? on How Facebook Can Out Your Most Personal Secrets · · Score: 1

    Can't read indeed. The article (most of it, anyway) is behind a pay wall. Care to do a cut and paste for us?

  24. Re:What exactly did he say? on US House Science Committee Member: Evolution Is a Lie From Hell · · Score: 1

    It is up on the church's website: http://libertybc.ws/ministries/sportsmanBanquet.cfm There is a youtube clip of his "testimony".

  25. hypocracy? on US House Science Committee Member: Evolution Is a Lie From Hell · · Score: 3, Interesting
    Well, how about applying his own test to the comments under scrutiny? From his own home page http://broun.house.gov/ at the HoR website:

    BROUN'S 4-WAY TEST

    I am committed to protecting the constitutional rights and pocketbooks of every American. I will apply the following four-way test to every piece of legislation that comes before the House for a vote:

    1) Is it Right/Moral?
    2) Is it Constitutional?
    3) Is it Necessary?
    4) Is it Affordable?

    Ask Slashdot: Is Paul Broun fit to be:

    1) A US legislator - responsible for national policy affecting Science, Space and Technology.
    2) A medical professional - tasked with health care of the sick and ill.
    3) An American Citizen - (ideally) part of a rational, responsible, and well-informed electorate.
    4) A Christian - committed to following the teachings of Christ.
    5) A Homo Sapien - the name, more or less, means "of the same wisdom/intelligence".