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Why Do Pathogen Researchers Face Less Scrutiny Than Nuclear Scientists?

Lasrick writes "Derrin Culp of the National Center for Disease Preparedness explores the different levels of scrutiny that scientists in microbiology undergo, when compared to those who work in the nuclear weapons field. His complaint is that, even though America's most notorious biosecurity breach — the 2001 anthrax mailings — was the work of an insider, expert panels have concluded that there is no need for intrusive monitoring of microbiologists engaged in unclassified research."

227 comments

  1. Intrusive Monitoring for Everybody! by Anonymous Coward · · Score: 0

    Let's all pass around some intrusive monitoring, sound good?

    Let's do anal probes with the morning latte, and lie detectors with the evening beer!

    Huzzah?

    1. Re:Intrusive Monitoring for Everybody! by davester666 · · Score: 5, Informative

      What is intrusive anymore?

      Things you don't need a warrant for:
      -tracking someones travels via their cell phone
      -reading their email
      -any call that originates from another country or is destined for another country can be monitored/recorded
      -who they have called/texted
      -any and all business records [actually, are there ANY limitations on NSL's?]
      -lots of other stuff, based on secret interpretations of laws, cherry picked from "friendly" lawyers, which you are not permitted to know about

      --
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    2. Re:Intrusive Monitoring for Everybody! by Anonymous Coward · · Score: 0

      Intrusive is probing your posterior. Everything else is fair game.

  2. Oh god, please die in a fire right now by Samantha+Wright · · Score: 0, Troll

    It's because no biological weapon could ever be as effective as a chemical one. You want something to worry about? Think about all of the millions of gallons of hydrofluoric acid used every day in glass etching. That is dangerous. Not some little bug that takes four days to incubate and can be eradicated with antibiotics and ultraviolet light.

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    1. Re:Oh god, please die in a fire right now by Anonymous Coward · · Score: 1

      That's incredibly naive.

      I'm sure that there are certain sequences of nucleic acid or protein that, once synthesized and not "contained" could represent an existential threat to life on this planet.

    2. Re:Oh god, please die in a fire right now by Anonymous Coward · · Score: 1

      Also, there's no reason to suspect that engineering an infectious agent that spawns a global pandemic is impossible, even if the agent is easy to neutralize.

    3. Re:Oh god, please die in a fire right now by Anonymous Coward · · Score: 1

      Im incredibly worried about biological attacks. If there was any reason that we should have universal healthcare it is the threat of biological weapons. It's national defense.

    4. Re:Oh god, please die in a fire right now by The+Master+Control+P · · Score: 2

      You do realize that biological agents do something that chemicals don't, right?

      Spill any chemical you want - that's all there is and all I have to do to escape it is not go where it's laying. Weaponized anthrax? Smallpox? Pandemic flu? Yeah, good luck escaping that shit by staying away from the place of the initial outbreak.

    5. Re:Oh god, please die in a fire right now by Samantha+Wright · · Score: 1

      The plague took months to spread around Europe when there was no sanitation whatsoever. As a weapon of mass destruction, diseases are (a) wildly impractical and (b) much less convenient than many alternatives.

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    6. Re:Oh god, please die in a fire right now by Bowling+Moses · · Score: 1

      "I'm sure that there are certain sequences of nucleic acid or protein that, once synthesized and not "contained" could represent an existential threat to life on this planet."

      Nope. Nucleic acid is not terribly stable stuff and for relatively short sequences every possible combination already exists in nature. Proteins aren't terrifically stable either and the vast majority require a three dimensional fold on top of the chemical structure in order to function. You can get rid of that fold-denature the protein-by a large number of means. Even if you still have properly folded protein its activity is heavily impacted by temperature, pH, presence of salts, concentration, etc. Life has evolved over billions of years to consume, break down, and reuse nucleic acids and proteins. The risk factor is around that of somebody manipulating water to go all ice-nine on us.

    7. Re:Oh god, please die in a fire right now by Samantha+Wright · · Score: 1

      It's not. There aren't. And if there were, it would be cheaper to do anything else, like one of the many missing Russian nukes. All things die when left alone in the wild. This fearmongering is the product of years of zombie fantasies in popular culture. All of it is utter nonsense.

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    8. Re:Oh god, please die in a fire right now by Anonymous Coward · · Score: 0, Troll

      Dr. Critchon, I thought you were dead.

      You are so mentally deficient you cannot even spell Crichton correctly.

      Quit posting and go smoke some cock, you mentally deficient lowlife faggot
      piece of subhuman waste.

    9. Re:Oh god, please die in a fire right now by Anonymous Coward · · Score: 0

      Also, there is no good way to stop them from infecting your own populace at a future point. It would be the pinnacle of stupidity to unleash some type of unstoppable virulent pathogen onto the world. No rational nation would ever do such a thing. Anyone that cares about their people and doesn't want to hurt them would know better. I mean, Kim Il Sung is way smarter than ... wait ... oh, shit.

    10. Re:Oh god, please die in a fire right now by flayzernax · · Score: 1

      Thats not necessarily true. There some pollutants that stick around for a good while. Some of those could be mixed into a bioengineering bacterium that would stick around for awhile in the environment as well. Again its all unpredictable, but you could really screw up an ecosystem for decades by using 1 pathogen targeted at the right environment with the right payload.

      DDT is a chemical that comes to mind. Something like that wouldn't be as dramatic as zombies but would definitely make for a devastating affect over a long. Really great if you planned for a war of attrition and wanted the enemies food supply to become unreliable.

    11. Re:Oh god, please die in a fire right now by Samantha+Wright · · Score: 2, Interesting

      Oh, yes. A doomsday device that gets preyed upon by every protozoan, yeast, and bacterium in the world. How brilliant. At least that rules out any organization other than a lunatic from employing it!

      Why do you think MRSA—by all means a real, legitimate biological threat that isn't the fantasy of a powerhungry politician—is only found in hospitals and factory farms? The metabolic cost of the antibiotic resistance makes it vulnerable to the environment. The more radically efficient a disease is, the worse it is at killing. Even exceptional pathogens are meagre: "during the outbreak the fatality of SARS was less than 1% for people aged 24 or younger, 6% for those 25 to 44, 15% for those 45 to 64, and more than 50% for those over 65."

      Furthermore, what would controlling American researchers accomplish? The United States does not have a monopoly on disease research. Surely a much greater threat comes from disease research laboratories in less developed countries with more corrupt governments rather than the exceptional person in a generally healthy, secure, and safe working and living environment. Moreover, despite the lack of a direct oversight mechanism, there is still a great deal of internal review, and it is implausible that an academic would have the resources to work on a project such as this without scrutiny and authorization.

      Ultimately, this approach seeks to treat with suspect people who do sensitive work. In less fortunate populations that has been shown very thoroughly to induce criminality. Ivins, the prime suspect of the "Amerithrax" case, was known to be mentally unstable and once saw a counsellor, who was apparently terrified of him. He should have been directed to another therapist, but wasn't.

      So there you have it. The only real scenario that has ever occurred, which this policy seeks to prevent, and it was caused by a failure of the psychiatric system. And no one died.

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    12. Re:Oh god, please die in a fire right now by Anonymous Coward · · Score: 0

      One of my friends works in a lab focused on lots of nasty stuff -- everything you've heard about being weaponized and more. There are exceptions, but in most cases the measures needed to protect the workers from their work are extremely unimpressive. Much of the time it's just gloves and keeping the work under a hood, like in your standard Bio 101 lab. It's not exactly a fair comparison, I know, but you're not going to find a lot of similarly casual safety among people handling live nuclear material.

    13. Re:Oh god, please die in a fire right now by Samantha+Wright · · Score: 1

      That's merely a popular misconception of cult leaders—they're not that short-sighted. Even North Korea's current sabre-rattling is an attempt to get something out of the UN and the US.

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    14. Re:Oh god, please die in a fire right now by Samantha+Wright · · Score: 0, Offtopic

      Pretty sure it's past your curfew.

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    15. Re:Oh god, please die in a fire right now by Anonymous Coward · · Score: 0

      Nucleic acid is not terribly stable stuff and for relatively short sequences every possible combination already exists in nature.

      You've proven this? Can we see your data?

    16. Re:Oh god, please die in a fire right now by Anonymous Coward · · Score: 0

      Happily, you're not the one making policy decisions on this.

      Ebola comes to mind.

      Go back to your corner.

    17. Re:Oh god, please die in a fire right now by Samantha+Wright · · Score: 1

      I don't think you know a thing about evolution.

      Multiple antibiotic-resistant bacteria are not found in the wild unless there is an excess of antibiotics significant enough to justify the metabolic cost of wasting energy on keeping the resistance alive. What bacteria do not need, they do not keep. Take the patients out of the hospitals and they will do just fine. You should have picked a better example, like Russia's tuberculosis epidemic, but I get the feeling that if you had anything more than surface knowledge about this subject, you wouldn't be throwing such childish words around. Engineered mutations are fragile.

      The reality is that the real biological threats to human health don't need us to enable them. Malaria kills millions of people a year, and has been doing so since the beginning of human history—it kills so many, in fact, that most deaths go unreported and it's believed that the real figures may be ten times higher than what we can verify. And it does it without any engineering or mentally unstable biochemists getting in the picture. This proposal is a complete waste of money that will only bring misery to the researchers it affects.

      So, really, take your paranoid babytalk and go back to your basement.

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    18. Re:Oh god, please die in a fire right now by stevez67 · · Score: 1

      Try reading scientific journals before showing off your lack of knowledge ... there are some organisms and some sequences of nucleic acid that could be used as bio-weapons but they wouldn't be a "threat to life on this planet". Those that could be weaponized are maintained very securely, use and access is tightly controlled and restricted, and they are quite expensive and cumbersome to do research with or on.

    19. Re:Oh god, please die in a fire right now by Anonymous Coward · · Score: 0

      The problem with biological weapons is what happens when you release them at major airport, by the time the symptoms make a pattern every country with enough money for even occasional flights from the "upper classes" has been infected. Also even near 100% survival with hospital treatment can look very bleak when all the hospitals are full. But this cuts both ways. even most religious terrorists wont use them, their country's and people who follow their cause will suffer the worst- compare religiosity scores to economic development for the reason, you need money for heath care. I say most for a reason however if you view civilisation as worth destroying and will consider your compatriots deaths to be justified martyrdom then you might want to.

      This does not mean however that biological weapons are automatically doomsday devices, the details matter, incubation period, infection rates, transmission requirements, lethality rates with varying levels of treatment (drug resistance/effectiveness ect) and the cost of that treatment in scares resources(eg blood for hemorrhagic fever). Chose the wrong disease and it is not much more than an inconvenience on a national scale, and *if* it gets taken seriously the quarantine will cut spread and may even give time for immunisations.

      So, scary, random, may hurt the users more than the targets - and all this leaving out what will happen if anyone finds out who released it. But if it does happen it could be horrific, it wont end civilisation but it could seriously ruin the lives of pretty much everyone for years, even decades afterwards. So should we look at these experts? NO - it does not take an expert to do this, hence the fear factor. It might not work but any clever organised graduate with a biology degree and a decent wad of cash could set an attack like this up with little suspicion. The thing that stops this from happening is that only the crazy or stupid would want to do this anyway and it would take a lot of clever organisation to pull it off. The best thing to do is prepare quarantine plans keep hospitals well drilled and make shure that the international disease warning systems are well funded, all of which have the benefit of being effective against more common but smaller threats.

    20. Re:Oh god, please die in a fire right now by ColdWetDog · · Score: 1

      Happily, you're not the one making policy decisions on this.

      Ebola comes to mind.

      Go back to your corner.

      Speaking of corners, Elboa sits in one. It's not a very good bioweapon. Really virulent viruses tend to be crappy weapons. Once you kill your vector, you're pretty much dead yourself unless you simultaneously invoke the deux ex machina of a Zombie Apocalypse.

      Now that would be a good bioweapon. Even the CDC agrees with that.

      --
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    21. Re:Oh god, please die in a fire right now by Samantha+Wright · · Score: 2

      They do get higher—there are a handful of BSL-4 labs where everything is vacuum-sealed, and personnel suits have life support systems that are kept under positive pressure. It sounds like you're describing a BSL-2 lab, which can be used to study (for example) hepatitis, but not tuberculosis or anthrax, which are BSL-3. BSL-3 labs require either constantly working under a hood or special safety equipment. Different safety levels may be found in adjacent rooms, so it's easy to get confused.

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    22. Re:Oh god, please die in a fire right now by Samantha+Wright · · Score: 1

      Ebola and TB could be imported from Africa by anyone, though. Why harass researchers?

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    23. Re:Oh god, please die in a fire right now by Samantha+Wright · · Score: 2

      No, a biology degree isn't even required—just a well-concealed sample imported from a third-world country in your carry-on luggage, like a mosquito with malaria. No exposure to academia of any kind needs to be involved, and it certainly doesn't make sense to harass researchers who are likely to wind up in the middle of the quarantine area. With nuclear weapons this all makes sense because the transfer of technology could give a vulnerable country a bartering chip in world politics, and a scientist giving up this information does not put himself or herself in danger to do so. But with biology, the resources are already available.

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    24. Re:Oh god, please die in a fire right now by RsG · · Score: 1

      This fearmongering is the product of years of zombie fantasies in popular culture. All of it is utter nonsense.

      Second that. Though it's not just zombies.

      Plagues, both natural and manmade, are a staple of apocalyptic fiction. Current craze is zombies, but they're a recent (and effective) retelling of a very old meme.

      Stop me if you've read this one: "PLAGUENAME a (virus/bacteria/prion/plot device) created by (godless researchers/actual god(s)/mother nature/snidley whiplash) swept the globe after (accident/outbreak in the third world/contrived event) killing (millions/billions/everyone but our heroes), and turning our cities into haunting graveyards". When you can make a mad libs version of what is essentially the same story, it's officially become a cliche.

      Now, reality time. The worst plagues in recent history were the 1918 flu epidemic and the HIV pandemic, while the worst in ancient history were the black death and smallpox. These are the killers that the cliche above sprung out of. They set the bar.

      They aren't even close to apocalyptic. Especially not on a global scale. Even a pathogenic perfect storm is at worst a regional catastrophe.

      Is this any surprise? Fiction always takes things further than reality. If the world conformed to our fantasies, we'd have moon cities twenty years ago. Reality is a huge letdown sometimes. Not that that stops people from believing; you could probably make a killing by selling lunar real estate with the promise that it'll be ready in twenty years.

      So you get people who think that yes, it really is possible to bring about the end of the human race via pathogen. And those same people will look at something like the 2001 anthrax attack and think the sky is falling, while reality being what it is, the total death toll for that was single digit. The article is pandering to that mindset.

      --
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    25. Re:Oh god, please die in a fire right now by Samantha+Wright · · Score: 2

      ...and let's be honest, if nature was going to do it, it's had fifty million years to make a move, y'know?

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    26. Re:Oh god, please die in a fire right now by __aaltlg1547 · · Score: 1

      The plague took months to spread around Europe when there was no sanitation whatsoever. As a weapon of mass destruction, diseases are (a) wildly impractical and (b) much less convenient than many alternatives.

      The Spanish Flu took about six weeks to go from barely noticeable levels to its peak. Other flu strains do the same.

    27. Re:Oh god, please die in a fire right now by Anonymous Coward · · Score: 0

      Once you kill your vector, you're pretty much dead yourself unless you simultaneously invoke the deux ex machina of a Zombie Apocalypse.

      Not only that but nothing says "stay away and don't get infected" like making your host bleed out.

    28. Re:Oh god, please die in a fire right now by Samantha+Wright · · Score: 1

      And they're all similarly non-perilous in the face of modern medicine.

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    29. Re:Oh god, please die in a fire right now by sgt+scrub · · Score: 1

      "during the outbreak the fatality of SARS was less than 1% for people aged 24 or younger, 6% for those 25 to 44, 15% for those 45 to 64, and more than 50% for those over 65."

      Are you saying it is less important because it is a possible resolution to the "social security crisis"?

      What?!? I couldn't find any of the expected juvenile jokes involving scientists, small things, and magnifying glasses.

      --
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    30. Re:Oh god, please die in a fire right now by Lehk228 · · Score: 2

      ordinary pathogens tend towards less lethal simply because killing off all available hosts is bad for business and will likely lead to extinction of the strain.

      however, engineered pathogens are not subject to such restrictions, modify a rhinovirus so that it also craps all over p53 and now you have a cancer causing cold.

      --
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    31. Re:Oh god, please die in a fire right now by __aaltlg1547 · · Score: 1

      Ebola IS very dangerous to humans and it does spread, but there have been a lot of outbreaks and they always burn out in a few days. It kills its victims too fast to spread rapidly once people are aware that people are getting sick. To be a big threat to humans, a disease has to have a longer incubation. Smallpox, for example, had an incubation period of about 12 days.

      Interestingly, during the 19th and early 20th centuries, a less-virulent form of smallpox evolved, called "variola minor." Patients with this form didn't get as sick but it was higly communicable. The minor form spread rapidly and might eventually have made full-blown smallpox extinct if the eradication campaign hadn't made both forms extinct in the wild.

    32. Re:Oh god, please die in a fire right now by Samantha+Wright · · Score: 1

      Honestly, Malaria would give far better results, in which case harassing disease researchers won't accomplish anything. My point was that engineered diseases are futile.

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    33. Re:Oh god, please die in a fire right now by Anonymous Coward · · Score: 0

      I just looked it up and it's BSL-3. Not that it adds a lot to the discussion.

    34. Re:Oh god, please die in a fire right now by __aaltlg1547 · · Score: 1

      And they're all similarly non-perilous in the face of modern medicine.

      That's not correct. The Spanish flu was a particularly deadly strain, unlike most other flu variants before and since and we don't really know why it was so bad. It is completely possible for a deadly new flu (or other disease) variant to crop up for which we just don't have the proper medicines. Flu outbreaks can be reduced with vaccination campaigns, but that depends on the correct prediction of what flu types will be going around in a few months. Sometimes the flu shots are effective and sometimes they're not because the formulators guessed wrong. There are now antivirals like Tamiflu, but not all types of flu are susceptible to it.

    35. Re:Oh god, please die in a fire right now by Samantha+Wright · · Score: 1

      Your suggestion is a perfect example of why engineering wouldn't work.

      Rhinoviruses are successful because they mutate rapidly. The only thing that prevents them from corrupting their genes completely and disappearing is the tiny chance that they won't misfold and will, instead, produce new viable virions after host infection.

      A payload protein specifically meant to interfere with a normal cellular function would (a) be selected against due to a high rate of failure and (b) not serve the virus in any capacity, thereby causing it to fail through mutation. (And I don't know enough about virology to say for certain, but I don't think enteroviruses integrate with the genome normally, so there goes that approach.)

      You would probably have more luck trying to engineer a really aggressive strain of HPV, but that's easily eliminated with sanitation.

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    36. Re:Oh god, please die in a fire right now by Samantha+Wright · · Score: 1

      And there's a key theme—communicability is inversely proportionate to impact, particularly with viruses. They don't really have incubation periods; cells get infected and effects worsen until the immune system can't keep it under control. If the symptoms are extreme, people die right away. And if you really want to kill a handful of people immediately, why bother with a disease at all? Envelopes of anthrax spores is a gimmick that works once before everyone gets suspicious. There is no advantage over a normal assassination or a poison gas attack.

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    37. Re:Oh god, please die in a fire right now by russotto · · Score: 1

      however, engineered pathogens are not subject to such restrictions, modify a rhinovirus so that it also craps all over p53 and now you have a cancer causing cold.

      Subtle, and possibly quite effective at cleansing the earth of its two-legged parasites, but I prefer the more direct and messy approach of using the Ebola glycoprotein.

    38. Re:Oh god, please die in a fire right now by Samantha+Wright · · Score: 1

      In that case, most of the precautions taken are in the fume hoods. If a BSL-3 lab has a containment breach, typically the entire building will go under quarantine until everyone has been properly screened; a friend of mine had the misfortune of going through one once.

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    39. Re:Oh god, please die in a fire right now by Samantha+Wright · · Score: 2

      The mechanism is actually understood, now; like SARS and H5N1 it causes a cytokine storm. A 2003 publication produced results suggesting that cytokine storms can be treated. Moreover, both SARS and H5N1 were largely defeated by public awareness and proper sanitation; in contrast, the 1918 flu spread throughout Europe in a time when military censors prohibited publication about it, making things worse. In fact we call it the Spanish flu because Spain wasn't subject to that censorship.

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    40. Re:Oh god, please die in a fire right now by Samantha+Wright · · Score: 1

      You sound like you have a very childish grasp of sexuality.

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    41. Re:Oh god, please die in a fire right now by Anonymous Coward · · Score: 3, Informative

      Apocalyptic plagues are an evolutionary dead end. If it kills quickly and surely enough to be a weapon, it's not a particularly fit organism because its host will tend to die before they can infect others.

      I'm far more scared of pathogens than nukes, though, and I don't think this idea deserves the derision it's getting. Prion diseases, for example, are really terrifying stuff. The kuru strain of the CJD prion, for example, exhibited an incubation period of between 5 and 20 years. If you were really determined, you could get that disease into a lot of people before it started showing itself.

      Look up Biopreparat. Look up the Marburg virus. This is very useful, very worthwhile research which we should be spending a great deal of effort on, but it's also the kind of research that could end up destroying a civilisation. Is it really so terrible to suggest that perhaps we should be a little more protective than we already are?

    42. Re:Oh god, please die in a fire right now by Samantha+Wright · · Score: 1

      Weaponisation of prions is an interesting angle I hadn't considered, although it looks like research into BSE and CJD is far enough along that, if Kuru were weaponised today and spread amongst a million people, we would notice it and cure it before it started causing symptoms. (That might be a little on the optimistic side, but presumably funding and other resources would be reallocated in such a situation.) Engineering new prions also seems like a woefully wasteful plan, and ultimately all such superdiseases run into a classic shortcoming of zombie stories: it's not currently practical to defend yourself or your people from getting infected, too.

      The Marburg virus, like other BSL-4 diseases, falls under the other clause of this debate, which is that it doesn't require a biologist to disseminate, and so monitoring researchers wouldn't do a lick of good. I've already noted similar of other diseases like Ebola. As a general rule such diseases kill so aggressively that they can be only used with a handful of targets, in which case it would be more reliable and cost-effective to send a hitman, or use a nerve gas attack.

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    43. Re:Oh god, please die in a fire right now by Anonymous Coward · · Score: 0

      So, something like Lassa with a 6 to 21 day incubation period? Crimean–Congo with a flu-like appearance for about a week where the person is contagious? Maybe MARV or RAVV . . . I don't know their incubation times off hand. HPS could be nasty, another week long incubation followed by days to week of infection spreading, with 60% fatality rate.

    44. Re:Oh god, please die in a fire right now by Anonymous Coward · · Score: 0

      And yet, it was one little bug that in a 5 year period wiped out 1/3 of the world's population. Likewise, another takes roughly 10% of all deaths each year.

    45. Re: Oh god, please die in a fire right now by Doubting+Sapien · · Score: 3, Interesting

      So far diagnosis of prion infections can only be reliably done using post-mortem detection of PrP, which is too late in most cases. The incubation period of most prion disease, measured in months and years, makes it a very poor bio-weapon candidate. While the argument can be made that military research can make progress toward that end, the practical reality is that it is still a not very well understood disorder and a lot of basic research is still needed despite intense and public scrutiny (for obvious reasons) from the agricultural sector of developed nations. Treatment options at the moment are virtually non-existent. Containment and culling to halt the spread of infection is still the order of the day in most agro scenarios. But this has been difficult where the infection exists in wild populations. Studies from a Colorado wildlife research facility where chronic wasting disease is endemic in local elks and deers have shown that prion infections can persist dispite conventional cleaning and sterilization methods. Other research shows that livestock to human transmission are not the only cross-species cases with examples being observed in minks from fur farms and guinea pigs in the laboratory also being suceptable. Such realities have resulted in hunters and recipients of venison from road kill being publicly cautioned from consuming the meat of animals from area known to have infected populations. There are a few efforts in very early experimental stages, but owing to the still very immature understanding of prions in general, it is still effectively a fatal disease with know cure/treatment options in human.

      --
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    46. Re:Oh god, please die in a fire right now by Lehk228 · · Score: 1

      i am sure it would not be point and click VB.net simple as i describe, but working in some type of hardening code to partially protect the payload should help longevity, and you only want limited longevity, a nice bloom is desired, a global kill pandemic is not (unless the party engineering the virus is a human-extinction advocate)

      --
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    47. Re:Oh god, please die in a fire right now by Anonymous Coward · · Score: 0

      Ebola and TB could be imported from Africa by anyone, though. Why harass researchers?

      citation?

    48. Re:Oh god, please die in a fire right now by Samantha+Wright · · Score: 1

      You don't need a citation for that, just a clever method of concealment at airport security, an experienced drug mule, or any other common household method of smuggling.

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    49. Re:Oh god, please die in a fire right now by Samantha+Wright · · Score: 1

      If you're referring to the Spanish flu as your "one little bug", it lasted for three years and only killed 3-5% of the population. Furthermore, it was only able to spread as effectively as it did because of a communications blackout. Today, it would be no more dangerous to public health than SARS.

      And if you're thinking of Malaria as your "another", that's somewhat treatable with Mefloquine, and like all existing diseases, could easily be imported by a smuggler.

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    50. Re:Oh god, please die in a fire right now by Samantha+Wright · · Score: 1

      You'll have to get in line behind the rest of 4chan. Is this a parlour trick, or do you talk like this during job interviews too?

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    51. Re:Oh god, please die in a fire right now by dbIII · · Score: 1

      The virgins are noisy again today.

    52. Re: Oh god, please die in a fire right now by Samantha+Wright · · Score: 1

      I think the proposed usage was more of a "I want to destroy all of civilization by poisoning schoolchildren's lunchmeat" scenario than a targeted weapon. This is a totally different scenario from normal warfare, for which an unmodified form of the disease vector would do just fine. Speaking generally, I would guess that the period before symptoms manifest on a given prion is unmodifiable, and is directly linked to that protein's role in the organism.

      --
      Bio questions? Ask me to start a Q&A journal. Computer analogies available for most topics!
    53. Re:Oh god, please die in a fire right now by dbIII · · Score: 2

      However the reality of 2001 was that the anthrax didn't spread everywhere after release. It's also the reality of a town near me where records of anthrax stored from WWII were found, so the canisters were dug up with great care and found to have rusted away years ago - it all got out but nothing happened because it doesn't quite spread the same way as in the movies.

    54. Re:Oh god, please die in a fire right now by Samantha+Wright · · Score: 1

      Unfortunately, anything in a virus that's static makes it vulnerable to culling by the immune system. A virus has to be able to change constantly in order to survive, and if you try to have it both ways, the frozen part will just stop working and be replaced by the dynamic part.

      --
      Bio questions? Ask me to start a Q&A journal. Computer analogies available for most topics!
    55. Re:Oh god, please die in a fire right now by khallow · · Score: 1

      If there was any reason that we should have universal healthcare it is the threat of biological weapons.

      Since it's not (the current system of people showing up in US (since that's the only place with this sort of debate) emergency rooms actually works just as well), the contrapositive of your conditional statement asserts that no reason exists for universal healthcare.

    56. Re:Oh god, please die in a fire right now by Pentium100 · · Score: 4, Interesting

      As I understand it, the body is quite efficient at neutralizing viruses or bacteria that it has encountered before because the body has to create antibodies that can kill a particular virus, but once those antibodies are created they can be recreated very fast. That's why vaccine works. The flu and cold viruses mutate rapidly so each time you get infected it's a "new" virus because your body could get rid of the old virus quite fast the second time.

      On the other hand, if somebody engineered a virus that has static genes, but very high mortality rate, it would no matter, since people would only get infected by it once (which would be the "first time") and then they would die. After all, human bodies do not keep a centralized antivirus database for the entire population ("John was infected by a similar virus once, here's how you build the antibodies"), just for the individual.

      So, the effectiveness of a static virus would most likely be limited by how fast a vaccine can be created and distributed.

    57. Re:Oh god, please die in a fire right now by TheTurtlesMoves · · Score: 1

      there is zero evidence that H5N1 causes a cytokine storm. In fact is was more mild than the previous strain from the previous year. Tamiflu however made a lot of money.

      --
      The Grey Goo disaster happened 3 billion years ago. This rock is covered in self replicating machines!
    58. Re:Oh god, please die in a fire right now by Samantha+Wright · · Score: 1

      My mistake.

      --
      Bio questions? Ask me to start a Q&A journal. Computer analogies available for most topics!
    59. Re:Oh god, please die in a fire right now by Samantha+Wright · · Score: 3, Informative

      No, a static virus would be recognized by the body too quickly. The immune system constantly circulates a huge pool of antibody-producing cells, each of which detects a different target (antigen). If something gets detected, then the antibody-producing cell responsible is told to reproduce aggressively. The memory functionality is simply accomplished by keeping more of that cell line around. It's like a very basic single-layer neural network. Short of killing the entire organism simultaneously, no static virus can be effective. Even HIV, a very rapidly-mutating virus, has problems overcoming the immune system immediately following an infection.

      --
      Bio questions? Ask me to start a Q&A journal. Computer analogies available for most topics!
    60. Re:Oh god, please die in a fire right now by the+biologist · · Score: 1

      I'm far more scared of pathogens than nukes, though, and I don't think this idea deserves the derision it's getting. Prion diseases, for example, are really terrifying stuff. The kuru strain of the CJD prion, for example, exhibited an incubation period of between 5 and 20 years. If you were really determined, you could get that disease into a lot of people before it started showing itself.

      There is no such thing as a 'kuru strain' of the CJD prion. Prions are not infectious organisms. If you get exposed to pathogenic prions, the prions naturally found in your brain are converted into pathogenic prions. This process is more akin to crystallization, rather than a standard infectious process. If you get exposed to pathogenic prions from humans, cows, sheep, or gerbils... the course of the infection is only determined by how you were exposed, how much of the protein you were exposed to, and your own genetic situation.

    61. Re:Oh god, please die in a fire right now by the+biologist · · Score: 1

      Of course there is an easy way to prevent the agent from infecting your own populace at a future point... they're called vaccines.

    62. Re:Oh god, please die in a fire right now by Electricity+Likes+Me · · Score: 1

      No sequence of nucleic acid, by itself, is dangerous. It gets obliterated by the stuff on your finger, for example.

      You need to shoot it into an organism, get it stably being transcribed into proteins, and then after all that actually wind up with an organism that's viable and has good disease properties. Most "flesh eating bacteria" for example are normal throat bacteria that are normally harmless.

    63. Re:Oh god, please die in a fire right now by Anonymous Coward · · Score: 0

      If you want a zombie apocalypse, engineering an airborne rabies virus would be a good way to go, it takes a while to start showing symptoms and once it does, it's too late to treat.

    64. Re:Oh god, please die in a fire right now by sFurbo · · Score: 1

      No, you need a lot of DDT for it to affect an ecosystem. The reason POPs coudl do it was that we spread thousands of tonnes of them over our food supply, cities and nature. If you have the ability to do that to your enemy, traditional explosives would be much more effecient, and include much less risk for it to spread to your own food supply.

    65. Re:Oh god, please die in a fire right now by sFurbo · · Score: 1

      I was under the impression that, while the first versions of antiobiotic resistance made the bacteria ineffecient, we had seen evidence for the evolution of less expensive versions, allowing resistant bacteria to spread outside hospitals. Is that wrong?

    66. Re:Oh god, please die in a fire right now by voidphoenix · · Score: 1

      There is no such thing as a 'kuru strain' of the CJD prion.

      The origin of the prion agent of kuru: molecular and biological strain typing

      Kuru is an acquired human prion disease that primarily affected the Fore linguistic group of the Eastern Highlands of Papua New Guinea. The central clinical feature of kuru is progressive cerebellar ataxia and, in sharp contrast to most cases of sporadic Creutzfeldt–Jakob disease (CJD), dementia is a less prominent and usually late clinical feature. In this regard, kuru is more similar to variant CJD, which also has similar prodromal symptoms of sensory disturbance and joint pains in the legs and psychiatric and behavioural changes. Since a significant part of the clinicopathological diversity seen in human prion disease is likely to relate to the propagation of distinct human prion strains, we have compared the transmission properties of kuru prions with those isolated from patients with sporadic, iatrogenic and variant CJD in both transgenic and wild-type mice. These data have established that kuru prions have prion strain properties equivalent to those of classical (sporadic and iatrogenic) CJD prions but distinct from variant CJD prions. Here, we review these findings and discuss how peripheral routes of infection and other factors may be critical modifiers of the kuru phenotype.

      That's just the first hit when you Google "kuru strain".

    67. Re:Oh god, please die in a fire right now by Stonefish · · Score: 1

      An organisms role is to generate more copies of itself, it doesn't matter if it wipe out 99% of the host during that periods as long as it spreads. If increased virulance spreads better than being benign the virulence wins as more copies of that clade will spread.

    68. Re: Oh god, please die in a fire right now by Doubting+Sapien · · Score: 1

      I think the proposed usage was more of a "I want to destroy all of civilization by poisoning schoolchildren's lunchmeat" scenario than a targeted weapon.

      I'm sorry for coming a bit late to the discussion. Who's proposal? It seems to me that a Kill-every-living-human/WMD-type device that takes months to years to take effect in a statistically small proportion of the exposed target population wouldn't be a very good way to achieve any kind of military or political objective in any sensible way. If on the other hand, you are a non-state actor trying to spread terror....I'll give you that, maybe. But still, there are no historic precedence to my knowledge of any extremist groups declaring to the world: "give us what we want or we will give you brain cooties". True, symptoms of fevers/bleeding/malaise of things like bird flu makes for dramatic visuals in the same way conveyed by WWI photos of soldiers blinded by mustard gas. In contrast, aside from the scary name of Mad Cow Disease, how many in the general public can identify the symptoms of vCJD much less know what it is? Put it another way, Do you think a terrorist would consider it a good idea to weaponize HIV? Similar in a lot of way - certainly easier to get and transmit, but just not practical from a common sense perspective.

      This is a totally different scenario from normal warfare, for which an unmodified form of the disease vector would do just fine.

      Exactly! In unmodified form, the disease vector is terribly inefficient - being statistically significant enough infection-wise to make your target sit up and take notice, but otherwise doesn't nearly approach the virulence that true pestilences of the past have cause death and destruction among the masses. It really isn't going to kill very many people. I guess what I am trying to say is, no matter how you cut it, prions - as we currently understand them - do not have the qualities of a good biological weapon regardless of what kind of war you are trying to fight with it. I would assert thus, that given the slow acting nature and generally vague symptoms (which can easily be mistaken for other neurological issues in the absence of post-mortem histological analysis), the only appropriate role for prions as a weapon of some sort is along the lines of some kind of assassination tool. That is, if other short comings can be addressed.

      Speaking generally, I would guess that the period before symptoms manifest on a given prion is unmodifiable, and is directly linked to that protein's role in the organism.

      Last I was aware, no one has yet divined the role played by PrP in living organisms. (It must be important though because the sucker is highly conserved across many species.) It has been a while since I've kept up with this stuff, so it is entirely possible that something within the last few months has been published that can be used to put numbers on this thing. However, The matter of symptoms can be really tricky to pin down. We've made great strides in illuminating many aspects of prion molecular biology, but not nearly enough to say we truly comprehend disease pathology. To complicate matters further, the brain is an incredibly resilient organ capable of taking quit a bit of abuse by adapting and compensating around damage. It may very well be the reason why symptoms take so long to appear is because victims brains are actively rewiring around parts damaged by plaque formation. I don't know if plasticity is something that has yet been quantified and/or standardized across all people. But given the range of brains, even in a place like slashdot, there are different levels of suceptability. I could very well be wrong, but I think it is premature to be asserting any kind of symptom time frame in association with a protein function that still isn't clear at all. From a strictly experimental perspective, however, I am optimistic analytic tools and techniques can be applied with further

      --
      ========== "Hello World" in my programming language of choice: ATG - LET THERE BE LIFE - TAG ==========
    69. Re:Oh god, please die in a fire right now by dunkelfalke · · Score: 1

      You forget the psychological effect. Certain diseases are way scarier than normal assassinations.

      --
      "It's such a fine line between stupid and clever" -- David St. Hubbins, Spinal Tap
    70. Re:Oh god, please die in a fire right now by Anonymous Coward · · Score: 0

      Nothing with an incubation period of 20 years will destroy humanity. There is time enough to reproduce in that timeframe - some lousy countries have an average life span of only 20 years. Now that is statistical, so some die young while others live to become 30. But it is the same way with disease. The incubation period varies, and there are usually some survivors for whom the disease didn't work.

      We are all infected by something lethal with a 80-year incubation period . . .

    71. Re:Oh god, please die in a fire right now by Pentium100 · · Score: 1

      Now I know. Thanks for the explanation.

    72. Re:Oh god, please die in a fire right now by Samantha+Wright · · Score: 1

      It happens, but only as long as the environment is a little contaminated. If there are no antibiotics around, then it's just dead weight. Environmental bacteria with antibiotic resistance are proof that we're massively overusing antibiotics.

      --
      Bio questions? Ask me to start a Q&A journal. Computer analogies available for most topics!
    73. Re:Oh god, please die in a fire right now by Samantha+Wright · · Score: 1

      Sure, but not scarier than a bucket of hydrofluoric acid! Chemical weapons are much better at producing dramatic horrors.

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      Bio questions? Ask me to start a Q&A journal. Computer analogies available for most topics!
    74. Re:Oh god, please die in a fire right now by pchimp · · Score: 1

      a clever method of concealment at airport security

      And the human body works pretty well for concealing such things. Just pay the airfare (and a small bit for the family) of a (likely) terminally ill individual and VOILA -- intercontinental transmission. Bonus points if you can get them to stop off in Madagascar first.

    75. Re:Oh god, please die in a fire right now by Anonymous Coward · · Score: 1

      You know what does have almost no problems overcoming the immune system at all? Parasitic worms. Even with medicine those things can be a daunting task to eliminate completely. and for some stupid reason doctors are terrible at detecting them.

    76. Re:Oh god, please die in a fire right now by Samantha+Wright · · Score: 1

      Right. As a general rule, eukaryotic parasites don't need our engineering to destroy civilization, just a little bit of transport.

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    77. Re:Oh god, please die in a fire right now by Samantha+Wright · · Score: 1

      Actually, they screen for that. You can be held for quarantine when leaving some countries if you're not able to prove good health.

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    78. Re:Oh god, please die in a fire right now by HiThere · · Score: 1

      O, that's correct enough. The conclusion doesn't follow, but the facts are correct.

      The chance of it happening by accident are quite low. As proof, we only have three or four instances in all of history. (Flu, black death, bubonic plague, maybe another one or two.)

      This, however, doesn't address the current situation. We now have a much denser and more mobile population than ever before. And we've been carefully incubating LOTS of microbes to be immune to all the treatments we possess. So there's lots of raw material. Having it happen by accident is thus more likely than ever before. (To be honest, it would probably only kill off humans and one or two other species. Depending on the exact route by which it became lethal.) Imagine if it were carried by flys AND could spread by contact.

      Now if we add malign human intent, it becomes quite probable. This is only unlikely because there's no plausible way that the malign humans could protect themselves and their associates. But many people don't think things through.

      Note that this still doesn't involve experts in the field. And doesn't even necessarily involve malign intent. Rats around a factory farm could pick up a disease of pigs that had been cultured in the midst of antibiotics. These could infect the rats in a pet shop with a disease that adapted itself to rats (so it no longer harmed them excessively) but which spread by contact. And some version of this could learn to live on people. It would quite likely be deadly, because it came from a significantly different species, but it could still spread through contact and, say, coughing. NO treatment would work, because it had inherited an immunity to all our antibiotics.

      FWIW, tuberculosis shows signs of breaking out in a new form that resists all current treatment. This isn't as quickly lethat as a new flu, because it's adapted to humans. But it's resistant to all known treatments. And many people who have it are living in the general population of several countries where free medical care isn't available. So expect it to spread worldwide.

      The only real answer to contagious diseases that resist treatment is quarantine. But people tend to avoid that because of the economic burden that it imposes on them. (There are also other reasons, but that's the really intractable one.) But even quarantine won't work if the disease becomes contagious before symptoms become blatantly obvious.

      P.S.: The burning of the houses of victims is one of the things that spread the plague. Don't believe we won't make equivalent mistakes.

      --

      I think we've pushed this "anyone can grow up to be president" thing too far.
    79. Re:Oh god, please die in a fire right now by HiThere · · Score: 1

      Yah. But if the incubation period were 5 years, and it were (slightly) contagious during the last two years before obvious symptoms...

      Then there's the question of how we would notice. If the symptoms were increasing lack of attention to detail slowly progressing over another 5 years to total unconsciousness (but not death). Since it is proposed to be very slow, there might well not be any obvious changes.

      OTOH, that kind of disease WOULD require an expert to fabricate it. Someone more expert than I believe currently exists. I find zoonotic diseases much more plausible, especially given factory farms. But it's also true that the current multi-drug resistant tuberculosis could mutate into a form that was much more contagious and not less deadly. Or there could be a vairant of measles that was resistant to the vaccine, and which had a much worse recurrence than sciatica. (You never kill off the measles virus. It lives on in hiding, waiting to reappear when your immune system stops suppressing it.)

      Note that these aren't generally humanity killers, but some of them might well be civilization killers. Or perhaps they would just drive us to eschew all human contact, and only use electronic communications...but robots aren't yet well enough developed to allow that to be practical.

      --

      I think we've pushed this "anyone can grow up to be president" thing too far.
    80. Re:Oh god, please die in a fire right now by HiThere · · Score: 1

      The rate of transmission of highly contagious diseases is related to the common speed of travel, and also to the fastest normal speed of travel, and also to the number (not percentage) of people travelling.

      So you can't say that because it took months to spread around Europe when the fastest speed was a fast horse, and the common speed was oxcart, and the number of people travelling was extremely low means that it would take months now. Actually it can take days to spread from New York to Shanghai. (It's usually a bit slower, but that's not the way you calculate threat estimates.)

      --

      I think we've pushed this "anyone can grow up to be president" thing too far.
    81. Re:Oh god, please die in a fire right now by HiThere · · Score: 1

      IIUC, weaponized anthrax can generally be avoided by not being where it is being used. That isn't, of course, true of the others.

      --

      I think we've pushed this "anyone can grow up to be president" thing too far.
    82. Re:Oh god, please die in a fire right now by HiThere · · Score: 1

      If by "effective" he means "targeted" (a defensible usage in this context) then his comment is defensible, though still, I believe, incorrect.

      Consider how effective mailing anthrax powder to a key Senator was in getting certain legislation passed.

      --

      I think we've pushed this "anyone can grow up to be president" thing too far.
    83. Re:Oh god, please die in a fire right now by flayzernax · · Score: 1

      Yep, I neglected to think of cost efficiency. Thanks for pointing that out.

      I do not know how cost efficient it might be to engineer a bacteria that poisons its environment though with something that doesn't kill its host but disrupts other parts of the food change or something that would stop nitrogen from re-entering the soil or something. (may be impossible)

      I would wager the cost to make oil devouring bacteria is probably close to the cost it would take to make an organism purely for disruptive purposes.

    84. Re:Oh god, please die in a fire right now by the+biologist · · Score: 1

      yes. you should also look into what a prion actually is.

    85. Re:Oh god, please die in a fire right now by Samantha+Wright · · Score: 1

      And yet the diseases that do manage to spread so quickly are aggressively contained due to improvements in sanitation and quarantining. SARS killed 775 people, mostly in China and Hong Kong, and there were only 8273 cases in total. The spreading characteristic of viruses and bacterial pathogens is all but defeated by modern practices.

      --
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    86. Re:Oh god, please die in a fire right now by the+biologist · · Score: 1

      In particular, you should read further than just the abstract of the paper you just referred to. The second sentence into the introduction is :

      Their central feature is the post-translational conversion of host-encoded, cellular prion protein (PrPC) to an abnormal isoform, designated PrPSc.

      This accurately tells you what a prion is and how the pathogenic process occurs. Because it is conversion of the host prion proteins, the only 'strain' that exists is the host. With regard to the pathogenic process, it is better to think of some people as 'kuru strain' while others are not.

      In general, it really helps to read what you cite. Don't worry, plenty of professional scientists don't do this... citing papers that don't actually have anything to do with what they're talking about in their paper.

    87. Re:Oh god, please die in a fire right now by sFurbo · · Score: 1

      OK, thank you for that, and thank you for bringing a lot of factual knowledge to the slashdot discussion, it is much appreciated.

    88. Re:Oh god, please die in a fire right now by the+biologist · · Score: 1

      The authors cited use the term 'molecular strain types', when they should have said 'molecular isoforms'. An 'isoform' is not the same as a 'strain type'. An isoform is a variation of a protein, due to a different gene sequence. Unless you're prone to referring to different types of soda pop as different strains, you really shouldn't refer to different isoforms as different strains either.

    89. Re:Oh god, please die in a fire right now by sFurbo · · Score: 1

      As Samantha Wright have pointed out at other places in this discussion, things that are of no benefit for the microorganism is bound to disappear withing days, as it is broken by random mutations.

    90. Re: Oh god, please die in a fire right now by AK+Marc · · Score: 1

      The incubation period of most prion disease, measured in months and years, makes it a very poor bio-weapon candidate.

      Make it incubate in 10 years with a very very high mortality rate, then poison the food in the exclusive schools. Before they have a chance to breed, the richest and brightest will start dying a horrible death. The country will collapse. Do it on a couple of countries that are growing faster than us and leap-frog over the "competition". Or spread it over Somolia and get rid of pirates (and everyone else).

    91. Re:Oh god, please die in a fire right now by AK+Marc · · Score: 1

      Just agree to go out with him, you know he can't speak in front of a real girl, that's why all his girls are inflatable, and his "fix" to that is saving up for a RealDoll.

    92. Re:Oh god, please die in a fire right now by AK+Marc · · Score: 1

      Anthrax caused quite the disruption, and it was engineered. Someone else mentioned weaponizing prions. Not a military weapon, like the flu could be (even the regular flu, or malaria like you mention would impair the other side enough for an advantage), but as a weapon of genocide.

    93. Re:Oh god, please die in a fire right now by AK+Marc · · Score: 1

      When it's weaponized, it's assumed you don't need a vector. You can infect directly with large canisters of infected water blown up in heatless explosions dispersing the germ over multiple square miles in infectious concentrations. Secondary infections are bonus, not required.

    94. Re:Oh god, please die in a fire right now by Samantha+Wright · · Score: 1

      Anthrax was a one-trick pony, now spent; people are too paranoid for that to work again. Someone said that as much could have been accomplished by mailing an envelope full of white sugar. The anthrax was not engineered or modified beyond the addition of powdered glass, which when mixed with the air would make the lungs of the victim more vulnerable. The mutations seen in the anthrax was simply a product of natural drift in the sample's genome—good for forensic fingerprinting, but not actually meaningful.

      Prions take years and years to become relevant; you may want to read the replies to that post where we summarily beat the idea to death. The difficulty of containment, low fatality rate, and ridiculous amount of research required to make them useful makes it solely the purview of Bond villains, much like stupidly large lasers and melting the ice caps.

      --
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    95. Re:Oh god, please die in a fire right now by AK+Marc · · Score: 1

      And if you really want to kill a handful of people immediately, why bother with a disease at all?

      Anything you can't see is scary. "An invisible killer took out Congress today." After all, it wouldn't be that hard to sneak in an aerosoled-weaponized disease in a fumigation canister designed to look like deodorant.

    96. Re:Oh god, please die in a fire right now by Samantha+Wright · · Score: 1

      An interesting strategy, but I've concluded it's probably nowhere nearly effective as just ignoring it.

      --
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    97. Re:Oh god, please die in a fire right now by AK+Marc · · Score: 1

      Anthrax was a one-trick pony, now spent; people are too paranoid for that to work again.

      The delivery was one-trick. But take 10 balloons of it (mostly helium, some anthrax powder in each one, no I will not blow up your baloons for you), and walk through a crowd, popping one every 10 meters. The concentration will not be high enough for guaranteed kills, but it will cause a fear of public spaces worse than the sniper attacks, and a fear of balloons. Your problem is that you understand it too much to understand it. It's not scary to you. That's where your logic fails. You expect the purpose of the attack would be to cause deaths, not to cause panic. And that's where you fail.

      Prions take years and years to become relevant; you may want to read the replies to that post where we summarily beat the idea to death.

      It was asserted to be a bad idea. That's not beaten to death. Nobody explained how large amounts of prions spread on meat products destined for school children in the elite private schools in China wouldn't destabilize China enough for a takeover in 20 years time. You are again assuming that the *only* purpose is to kill, and yes, prions are a poor choice for that. They aren't nearly reliable and dependable for that.

    98. Re:Oh god, please die in a fire right now by AK+Marc · · Score: 1

      The problem is you seem to assert a solution, but not follow it. How many times did you reply after determining that to be the optimal solution?

    99. Re:Oh god, please die in a fire right now by voidphoenix · · Score: 1

      First off, prions are infectious pathogens. It doesn't matter what the mechanism for infection is, just that the infection happens. Viruses have a different mechanism for infecting hosts than do bacteria, but we still refer to variants as strains. Soda cans generally aren't considered pathogens, so I don't refer to their variants as strains.

      You're implying that the only difference are the host's proteins and all the variance is accounted for by the host's genetic variations. But just like other pathogens, genetic variations in hosts result in different levels of susceptibility from different strains.

      You seem to have you panties in a knot about the use of the word "strain" to describe prion isoforms. Sorry to bust your pedantic bubble, but strain is commonly used in literature about prions. Of course, since you're posting on Slashdot, you must be a subject matter expert and know must know better than everyone else.

      Because it is conversion of the host prion proteins, the only 'strain' that exists is the host.

      Wrong. From the UCL Institute of Neurology MRC Prion Clinic:

      Although prions do not carry genetic material, they also come in several different forms - again known as strains. If prions are just proteins, how can they come in different strains? This has been a very important question. It is now clear that there is not just one rogue form of PrP that causes prion disease but there several distinct rogue forms.

      Oh look, they also use the word "strain" on that page, the horror!

      Aside from the authors I cited and the MRC Prion Clinic, a quick search shows hundreds of examples. They all must be wrong too, huh? Anyway, I'm going to go with the credentialed neurologists and researchers on this, as opposed to some random arrogant Slashdot pedant.

    100. Re:Oh god, please die in a fire right now by HiThere · · Score: 1

      Why do you characterise SARS as spreading aggressively? I know people were afraid that it would, but I didn't see any evidence that it spread as readily as the flu, or even measles.

      If you say "The spreading characteristic of viruses and bacterial pathogens is all but defeated by modern practices.", I'd want to know how those practices are applied in schools, bars, and public transit, not in hospitals and biology labs. (But even in hospitals those statements appear to be a vast overrating of actual practice, though certainly increased efforts are currently underway.)

      --

      I think we've pushed this "anyone can grow up to be president" thing too far.
    101. Re:Oh god, please die in a fire right now by Marxist+Hacker+42 · · Score: 1

      Not to mention the delivery methods are not very good or useful.

      --
      SJW: a person who perceives an injustice, and while correcting it, commits a greater injustice.
    102. Re:Oh god, please die in a fire right now by flayzernax · · Score: 1

      I had no idea how efficient nature was at selecting positive traits and weeding out the bad ones. I figured that really only went for things that were grossly or moderately detrimental to the organism.

      Thanks for enlightening this layman.

    103. Re: Oh god, please die in a fire right now by Samantha+Wright · · Score: 1

      The proposal being that of the AC to whom I was originally replying; who brought up prions in the first place. Its only real utility would be to weaken a general population (again, with foolishly low success rates.) I find it amusing how some posters are ignoring the ineffectiveness of these methods of killing and then saying "yeah, but I think it's scary," as though we should legislate against bogeymen.

      The "rerouting around plaques" explanation makes sense. I expect there's a maximum plaque formation rate which is mostly a function of the protein's normal kinetics, localization and availability.

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    104. Re:Oh god, please die in a fire right now by Samantha+Wright · · Score: 1

      You're kinda beating a dead horse here, buddy.

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      Bio questions? Ask me to start a Q&A journal. Computer analogies available for most topics!
    105. Re:Oh god, please die in a fire right now by Samantha+Wright · · Score: 1

      Outside of The Dark Knight, creating panic is not actually an objective of terrorism. It's much more important for them to prove that they can do anything at any time, which is a useful bargaining chip. Fear is useless unless it affects those being extorted.

      As for prions, it looks like vCJD may actually be practical as a weapon. Until the late nineties BSE epidemic in Britian, most known prion diseases cases were in people over the age of 55.

      The only numbers we have on any prion's success rate were of the first Kuru epidemic in the late 50s. 1 in 50 people were affected; with about 90% being women, and all women being potentially exposed to the disease, it is likely that the rate of problems was around 4%. If vCJD has the same characteristics, this seems like a very low-yield strategy compared to alternatives like chemical poisoning. There are plenty of methods that would be about as untraceable, and could give much more effective, rapid results.

      --
      Bio questions? Ask me to start a Q&A journal. Computer analogies available for most topics!
    106. Re:Oh god, please die in a fire right now by Samantha+Wright · · Score: 1

      Well, it's the closest example of a modern disease. There were only a dozen or so cases of H5N1 transmitting between humans; there aren't any other good examples of epidemics affecting Western countries in the last few years, except maybe the 1972 Yugoslavian smallpox outbreak, in which there were only 175 cases and 35 deaths due to vaccination and quarantine.

      "Modern practices" is, honestly, pretty simple: basic hygiene. Schools, bars, and public transit are all regularly sterilized. Simply washing your hands with warm water eliminates ninety percent of the bacteria on them. To contrast, there are millions of people in India who rely on the Ganges river for both drinking water and waste outflow—and it's not exactly segregated as to what goes into the river where. This is a major factor in the continued persistence of plague, cholera, and other diseases in those regions which Europeans would normally assume to be relics of history.

      The spread of disease in hospitals is a completely different problem. Because keeping those places sterile is so important, we've come to rely on antibiotics that are normally very effective, but target specific mechanisms inside of the bacterial cell in order to kill it. Against these weapons, bacteria have had a chance to evolve defences, due to frequent usage but insufficient thoroughness.

      --
      Bio questions? Ask me to start a Q&A journal. Computer analogies available for most topics!
    107. Re:Oh god, please die in a fire right now by AK+Marc · · Score: 1

      Outside of The Dark Knight, creating panic is not actually an objective of terrorism. It's much more important for them to prove that they can do anything at any time, which is a useful bargaining chip. Fear is useless unless it affects those being extorted.

      The terrorism of suicide bombers in crowds is mainly to demoralize the population to cause a loss of will of keeping up a fight. The panic is an objective, in that a disorganized and conflicted enemy is a weaker enemy. Panic is never the end goal (even in Batman) but a means to an end. Killing all the enemy isn't ever the "goal" of a war. "Winning" is the goal, and killing everyone else may be a means to the end, but isn't the end. Your focus on killing is irrelevant, as that's not even the goal of chemical attacks. Or the US's nuclear strikes against Japan. The goal wasn't to kill Japanese people, but to end the war. Demonstrating a chemical or biological weapon of less destruction may have had a greater effect on the will to fight because the fear itself is a desired outcome as an intermediate step to the desired final outcome.

      Sometimes the goal is a slow and predictable destabilization of a government/nation. And I can see a place in that for something with a 10 year incubation period.

    108. Re:Oh god, please die in a fire right now by Samantha+Wright · · Score: 1

      I'm not saying it wouldn't be a worthwhile tactic, but it goes against the philosophy of the nuclear and chemical strikes. The bombing of Japan and the attacks on the World Trade Center both attempted to say the same thing: you are defenceless. They were shows of force, intended to make the military itself feel vulnerable. The military can thwart the second wave of biological attacks against it easily, so there's no chance of lasting intimidation. Attacking already vulnerable civilians essentially contravenes the doctrine of "shock and awe," which has been a component of successful military strategy all the way back to Sun Tzu and the Roman Empire, and is likely to create martyrs, as 9/11 did.

      --
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    109. Re:Oh god, please die in a fire right now by Lehk228 · · Score: 1

      most worms are stupidly easy to prevent through adequate precautions and hygiene.

      --
      Snowden and Manning are heroes.
    110. Re:Oh god, please die in a fire right now by AK+Marc · · Score: 1
      If you give me 20 suicide bombers, I'll collapse the US air infrastructure. 2 the first week, one on each coast (LAX and JFK) blowing themselves up in the security line. Then, there'll be pre-security security lines. Wait a month for those to be set however the authorities assert is "best" Then blow up 2 more on the coast (SFO and Boston) as close to the detection point as practical. Then, evaluate the response and repeat the process in Denver and Chicago. You leave the middle until last so they feel safe, then over-react when it finally comes to them. 6 guys and the airports will be mostly shut down. If they aren't, car bombs at dropoff points at ATL and PHX with some of the remainder bombers. The point being to wait for the response, then respond to their response, showing it useless. When the people don't feel safe, and you've proven there's nothing the government can do to address that, then your job is done. I'm not sure what the intended response to 9/11 was, but it seemed to have the response desired. It pissed off the Americans and helped lead to financial troubles for the US

      The military can thwart the second wave of biological attacks against it easily, so there's no chance of lasting intimidation.

      You seem to prefer chemical to biological attacks, so that seems like a silly statement. The military's response to a chemical attack will likely render it immune to the next. Many of the preparations for chemical match biological. And both greatly reduce fighting ability, especially in hot climes.

    111. Re:Oh god, please die in a fire right now by Samantha+Wright · · Score: 1

      My idea of an effective chemical attack involves extremely vicious acid, not a toxin. Even so, chemical attacks are much faster-acting and can conceivably be employed without giving the enemy time to warn others.

      I'm not sure what the point of your bombing explanation was, since that qualifies as shock and awe (against the air transit system itself) and could not be implemented with biological weapons.

      --
      Bio questions? Ask me to start a Q&A journal. Computer analogies available for most topics!
    112. Re:Oh god, please die in a fire right now by AK+Marc · · Score: 1

      And I don't understand how you think chemicals are better than bio attacks when a hint of warning (or previous attack) and your vicious acid will have zero effect on the authorities - who will be all decked out in NBC gear.

    113. Re:Oh god, please die in a fire right now by Samantha+Wright · · Score: 1

      It's quite simple; extremely high concentrations of triflic acid can eat through anything but glass and teflon, including plastics and rubber. It spontaneously vaporizes if put in air that's even slightly humid, and the fumes can cause severe burns and blindness within seconds from several metres away. It can destroy buildings. And unlike a biological attack, everyone has to be outfitted with safety equipment; it can't be defeated by herding everyone into a room with extremely rapid ventilation.

      Chemical attacks aren't nearly as versatile as traditional warfare, no, but they have much more potential to cause actual damage than biological attacks.

      --
      Bio questions? Ask me to start a Q&A journal. Computer analogies available for most topics!
    114. Re:Oh god, please die in a fire right now by AK+Marc · · Score: 1

      The problem with your chemical attack is that you'd need to have all of it in a rooftop water-tower set to spill on the crowd. It would be useless in a subway situation. That's why toxins are used, rather than chemicals. What's the maximum damage that you can cause with one cup of liquid in a crowded subway? For biological weapons, the theoretical maximum is killing billions. For toxins, you could kill hundreds. For your acid, you kill no more than tens, perhaps with a higher rate of casualties, but maybe not.

      And I can mail-order trifilic acid for about $2000 per kg. Though results for "eats plastic" doesn't return anything indicating it eats plastic, so I'm not sure why you think a military NBC suit will not protect from a "common" industrial chemical.

    115. Re:Oh god, please die in a fire right now by the+biologist · · Score: 1

      The word 'strain' doesn't imply anything about pathogenicity. People refer to different strains of plants, animals, fungus, etc. that have no pathogenic modes.

      Prions don't replicate themselves. They convert pre-existing host prion proteins into an altered pathogenic conformation. If you have active prion disease, it is your own cellular-synthesized protein which has become mis-folded and is causing pathogenesis. The initial mis-folding in your body can happen sporadically or it can be triggered by mis-folded prion proteins from external exposure.

      It turns out there are different pathogenic ways the native prion protein can mis-fold and that these are referred to as 'strains', but that term doesn't imply what it means in other contexts. I'm not claiming that those articles are incorrect, I am claiming that you are misunderstanding those articles because you don't understand what prions are and how they work.

    116. Re:Oh god, please die in a fire right now by Samantha+Wright · · Score: 1

      From here:

      Because of the hygroscopic nature of triflic acid, handling and transfer under a dry, inert atmosphere is recommended. Contact with natural and most synthetic polymers (rubber, cork, common plastics) can lead to reaction. For this reason, storage in glass or PTFE containers is recommended.

      Triflic acid vapour aggressively spreads through the air. People I've known who've worked with triflic acid describe the phenomenon as shimmering smoke, a little like a halon extinguisher. A cup of the stuff could most likely kill everyone on a crowded subway platform (i.e., hundreds of people) within a minute, by burning their lungs and pulmonary edema. The more humid the environment, the more aggressively it spreads. Handling the stuff unprotected for only a couple of seconds will cause nosebleeds. People would be dead long before they realised what was happening, eliminating the chance that they could warn others (a major problem with slow-acting biological weapons.)

      Plenty of common industrial chemicals are seriously horrible, nasty stuff. While they do make PTFE-coated (teflon) hazmat suits specifically for handling spills of reagents like triflic acid, such suits are not appropriate for all toxins. One of the first things you learn in organic chemistry is that no material can protect against all chemicals.

      I think that's a lot more dangerous than a theoretical maximum which is trivially capped by a shower and a standard ventilator and would take years to reach.

      --
      Bio questions? Ask me to start a Q&A journal. Computer analogies available for most topics!
    117. Re:Oh god, please die in a fire right now by the+biologist · · Score: 1

      I had a misunderstanding about prions having multiple pathogenic folds which are commonly referred to as 'strains'. The term 'strain' is very often misconstrued by science writers in the media to mean the same thing as a 'strain' of bacteria, leading to most media discussions of the pathogen having many of the fundamentals wrong. I may have jumped the gun in thinking you were making the same mistake.

      Of course, since you're posting on Slashdot, you must be a subject matter expert and know must know better than everyone else.

      I am an actual practicing biologist in academia at a major research institution, but don't let that stop you from being a jackass and making claims that don't represent reality. Actual science, practiced by actual scientists, is full of arguments all the time. Scientific conventions are hothouses of drinking, dancing, and fighting. However, once you've decided to go with personal attacks, you're no longer doing science and should examine your motivations.

    118. Re:Oh god, please die in a fire right now by AK+Marc · · Score: 1

      a theoretical maximum which is trivially capped by a shower and a standard ventilator and would take years to reach.

      When you are considering the case where everyone in the subway is standing in a shower wearing a ventilator to be the "theoretical maximum" you are obviously no longer discussing things rationally. That leaves nothing left to say.

    119. Re:Oh god, please die in a fire right now by Samantha+Wright · · Score: 1

      The subway platform was a separate example. The fact remains that biological attacks remain less effective against prepared targets than chemical ones, and are easier to prepare against. Further, I already agreed with you that a sleeper attack on civilians is (in principle) a valid move when were discussing prions; just not compatible with major real-world doctrines.

      --
      Bio questions? Ask me to start a Q&A journal. Computer analogies available for most topics!
    120. Re: Re: Oh god, please die in a fire right now by Anonymous Coward · · Score: 0

      I am an actual practicing biologist in academia at a major research institution, but I don't let that stop me from being a jackass and making claims that don't represent reality. Actual science, practiced by actual scientists, is full of arguments all the time, so naturally I do my darned best to do the same, armchair shithead pedant that I am. Scientific conventions are hothouses of drinking, dancing, and fighting, just the kinds of places I like to go to satisfy my redneck proclivities. However, since I've decided to go with personal attacks, you need to stop provoking me because I'm burning brain cells trying to argue around the fact that I spat in the face of established science when I said there is no kuru strain.

      Whew! FTFY. You have no idea what a strain reading and editing your shit is. You really need to put your mouth in neutral and put your brain, assuming you have one, into drive. I realize you probably jerk off to seeing your name on the internet, or that the whole "publish or perish" thing has turned reading your name into some Pavlovian cum-on-command thing for you, but please, stop polluting Slashdot with your shit. Go fuck a goat or whatever it is idiot biologist jackasses like you do in their spare time.

    121. Re:Oh god, please die in a fire right now by voidphoenix · · Score: 1

      The word 'strain' doesn't imply anything about pathogenicity. People refer to different strains of plants, animals, fungus, etc. that have no pathogenic modes.

      Quite right. I didn't mean to imply that strains only referred to pathogens, just that the word strain is commonly used to describe varieties of pathogens, a category which includes prions.

      Prions don't replicate themselves.

      Neither do viruses.

      It turns out there are different pathogenic ways the native prion protein can mis-fold and that these are referred to as 'strains', but that term doesn't imply what it means in other contexts.

      What you're missing here is that not only are there are multiple variants of PrPc (normal form) protein, caused by variations in the PRNP gene, but that there are also multiple variants of the PrPsc (misfolded/prion form) protein (not just different ways of misfolding), and that different variants of PrPc result in different levels of susceptibility or resistance to different variants of PrPsc. These PrPsc variants are referred to as strains in pretty much all the literature, despite your claims that the use of the word is wrong.

      I may have jumped the gun in thinking you were making the same mistake.

      No, not "may have". You did jump the gun, despite the fact that I actually cited an example of the word strain being used to describe a prion variety in the literature.

      Of course, since you're posting on Slashdot, you must be a subject matter expert and know must know better than everyone else.

      I am an actual practicing biologist in academia at a major research institution,

      Argumentum ex cathedra: "I'm an expert, all you amateurs stand back!" Whatever your background and present situation may be, you're just plain wrong about prion strains.

      but don't let that stop you from being a jackass

      I started with a simple citation demonstrating that the word strain is used to describe prion varieties. You responded with the following:

      yes. you should also look into what a prion actually is.

      you should read further than just the abstract of the paper

      it really helps to read what you cite. Don't worry, plenty of professional scientists don't do this... citing papers that don't actually have anything to do with what they're talking about in their paper.

      Unless you're prone to referring to different types of soda pop as different strains

      Several thinly veiled strains of condescension implying that (a) I don't know what a prion actually is; (b) I didn't read what I cited; (c) I cited a paper that didn't actually have anything to do with what I was talking about; and (d) I'm an idiot. Thinly veiled, but easy to translate: I'm an ignorant buffoon and you're an expert, so I should stop playing in the same room as you. In other words, you were a jackass.

      Actual science, practiced by actual scientists,

      More ad hominem and ex cathedra. Now you're implying that I'm not an actual scientist practicing actual science, but you are.

      However, once you've decided to go with personal attacks,

      Except you decided to go with personal attacks, very thinly veiled ones.

      you're no longer doing science and should examine your motivations.

      Good advice. You should take it.

      and making claims that don't represent reality.

      You mean like:

      There is no such thing as a 'kuru strain' of the CJD prion.

      and

      the only 'strain' that exists is the host

      Both of those cl

    122. Re:Oh god, please die in a fire right now by the+biologist · · Score: 1

      Argumentum ex cathedra: "I'm an expert, all you amateurs stand back!"

      Note that this is exactly the opposite of what I did. I was pointing out that real science involves arguments, but thanks for playing. I made no "thinly veiled personal attacks". The closest I made to personal attacks was calling you a jackass in response to you making personal attacks. You accused me of thinking I knew better than anyone else, so I pointed out that I am a researcher and that real science involves arguments as a matter of course. Me having an argument means that I think something differently AND I want to know better about something.

    123. Re:Oh god, please die in a fire right now by the+biologist · · Score: 1

      you should read further than just the abstract of the paper

      it really helps to read what you cite. Don't worry, plenty of professional scientists don't do this... citing papers that don't actually have anything to do with what they're talking about in their paper.

      The introduction of the paper contradicted what you referred to in the abstract. (This is fairly common because condensing the entire paper into an abstract leads to information loss.) You focussing on what the abstract said, rather than what the paper said suggested you read the abstract, but not the complete paper. There were several citations from the paper which, when those papers were read, contradicted what the paper claimed those citations said. This indicates the authors are not in agreement with the community they're working in. (Again, fairly common.)

      Citing the number of Google findings from 'prion strain' also suggested a quick overview method of research review. Googling 'prion isoform' produced a similar, but larger number of hits. At best it suggests there might be disagreement over terminology among scientists researching prions. A more likely interpretation is that neither result means much, but referring to google as an authority could be interpreted as an attempt to prove superior Google-fu.

      Several thinly veiled strains of condescension implying that (a) I don't know what a prion actually is; (b) I didn't read what I cited; (c) I cited a paper that didn't actually have anything to do with what I was talking about; and (d) I'm an idiot. Thinly veiled, but easy to translate: I'm an ignorant buffoon and you're an expert, so I should stop playing in the same room as you. In other words, you were a jackass.

      (a)(b) How many of the papers cited by the paper you cited did you read? Doing so it made it clear that the authors in that paper were using the term 'strain' to mean what researchers in other communities mean by 'isoform'.

      (c) I was referring to citations that paper made which made it clear the paper you cited was talking about isoform differences.

      (d) I never said this in any way, nor do I think it is a relevant statement. If you know something that I don't, I don't think of myself as an idiot. If I know something that you don't, I don't think of you as an idiot. If we have a disagreement of opinion, I don't think either of us are idiots. Seriously?

    124. Re:Oh god, please die in a fire right now by voidphoenix · · Score: 1
      I'm not sure if this is worth the bother, since you seem to be completely resistant to accepting any correction, new information or indeed even the possibility that you might be wrong. Any of the three runs counter to the scientific method, all three together is dogma. But I'll try anyway.

      There is no such thing as a 'kuru strain' of the CJD prion.

      Because it is conversion of the host prion proteins, the only 'strain' that exists is the host.

      These are the statements you made that I am refuting. I quote them here for easy reference.

      The introduction of the paper contradicted what you referred to in the abstract.

      No, it didn't, and I'll explain why in a bit.

      You focussing on what the abstract said, rather than what the paper said suggested you read the abstract, but not the complete paper.

      Because I only needed an example of the use of the word "strain" to describe varieties of prions, specifically the kuru strain, and nothing more.

      There were several citations from the paper which, when those papers were read, contradicted what the paper claimed those citations said. This indicates the authors are not in agreement with the community they're working in. (Again, fairly common.)

      Irrelevant to our discussion, because we're not discussing their study, just the fact that there is a kuru strain and that the word "strain" is used in prion literature.

      Citing the number of Google findings from 'prion strain' also suggested a quick overview method of research review. Googling 'prion isoform' produced a similar, but larger number of hits.

      I only used Google to find examples of prion varieties being referred to as "strains" in scientific literature. Since you suggested this as a metric... prion strain: About 518,000 results; prion isoform: About 356,000 results. Searching for the exact phrases... "prion strain": About 30,400 results; "prion isoform": About 5,290 results. Not that those numbers mean anything.

      At best it suggests there might be disagreement over terminology among scientists researching prions.

      The disagreement isn't among prion researchers. They use "strain" and "isoform" to describe two different things. Again, explanation follows.

      The authors cited use the term 'molecular strain types', when they should have said 'molecular isoforms'.

      The authors used 'molecular strain types' because they meant 'molecular strain types' and not 'molecular isoforms'. You think they should have used the other phrase because you misunderstand what they mean, and I think I understand why there's confusion.

      Here's the promised explanation. In prion literature, we mainly study the protein PrP (aka CD230), which is encoded by the PRNP gene in humans. The normal form is referred to as the PrPc isoform or the normal cellular isoform (c for cellular). The pathogenic form is called the PrPsc isoform or the scrapie isoform (sc for scrapie). PrPsc is a misfolded PrPc and it seems to be able to cause existing PrPc to misfold into PrPsc. In prion research, there are two isoforms of PrP, the normal c and the misfolded sc.

      There are several gene polymorphisms of PRNP which express into slightly different forms of PrP. These are what are referred to as strains. The encoding genes are slightly different and the expressed protein sequences are slightly different. These different strains have a (naturally occurring) PrPc isoform and most of them also have a misfolded PrPsc isoform. The PrPsc isoforms of PrPc strains have slight compositional and structural differences, due to the base PrPc isoforms having those differences, hence the existence of PrPsc strains or prion strains. The use of the word "strain" for prions is essentially identical to that for bacte

  3. O'rly? by flayzernax · · Score: 1

    http://www.nytimes.com/2008/08/02/washington/02anthrax.html?pagewanted=all&_r=0

    Seems like biowarfare researchers make just as solid scapegoats as crazy nuclear physicists and MIT computer nerds.

    1. Re:O'rly? by EvilSS · · Score: 2, Funny

      I've tried this before but a FAGGOT is such a non-standardized unit of measure no one can seem to come up with a consistently working conversion. Sometimes we ended up with a carton of menthols. Sometimes a big bundle of sticks (why the fuck would I need that?) The worse were the times we ended up with a cheap beer swilling ex high school jock. Seriously inconvenient unit of measure those were and I couldn't trade them for anything useful!

      --
      I browse on +1 so AC's need not respond, I won't see it.
  4. scrutiny? from whom? by turkeydance · · Score: 1

    is scrutiny from A better and/or more reliable than from B? will multiple scrutinizers provide better data just because they're *more*? my position is: inviting more to the party invites more of absolutely everything.

    1. Re:scrutiny? from whom? by Anonymous Coward · · Score: 0

      scrutinizers

      The noun for the person is "scrutineer".

      You're welcome.

  5. The same reason there no more anti-war protests by Kohath · · Score: 0, Flamebait

    Why pick on nuclear science and the nuclear industry? For partisan political advantage. In the 70s and 80s, the anti-nuclear crowd was able to spread lots of FUD -- and they got unlimited media help -- because it helped the left gain political power. Pathogen research offered no such advantage.

    Where are the protestors for the drone war, BTW? Where was the "grim milestone" protest for Obama's 1000th US soldier killed in Afghanistan? Or his 2000th? No partisan political advantage means no (or very, very little) media coverage and no organized protests.

    1. Re:The same reason there no more anti-war protests by wanfuse123 · · Score: 3, Interesting

      I wrote an article on the Ulterior Motives: That killed the best nuclear solution to date for the US for nearly seventy years. That solution is LFTR Nuclear Reactors, If it hadn't been for the Oil industry, Nuclear Bombs, and Other Alternative Energy Movements, we would have a nearly endless supply of safe and cheap power. It goes to show you spreading FUD does pay off. Every time I post a message about LFTR reactors someone inevitable says something that is unfounded. Being as impartial a write as possible, I always entertain the arguments by giving them counter arguments which takes a lot of time from research for the defense. Nuclear is a solution and a good one. One the US would be smart to invest in. It would kill the Global Warming problem in 10 years with the right effort with the least environmental impact of any solution that can be deployed to date.

    2. Re:The same reason there no more anti-war protests by Idou · · Score: 2

      >For partisan political advantage. Really? Had nothing to do with a very possible nuclear war apocalypse (which almost happened, from my knowledge, at least once . . .).

      >Pathogen research offered no such advantage. Maybe if a version of the Nagasaki or Hiroshima bombings were to occur with pathogen research, you would start to see some more protests. Humans are not very good at understanding risks, such that it can take seeing cities of people perish in unimaginable hell before they actually care enough to get involved.

      The rest of your post gives examples that basically do not even come close to a "global apocalypse." In fact, your post seems more politically motivated than the protests against nuclear war. If nuclear science was also a target, I would consider it as just a casualty of being too closely associated with the very real threat of nuclear war apocalypse at the time. Seems some of the blame for nuclear science getting a bad wrap should go to weaponization and use against large numbers of civilians.

      --
      Sdelat' Ameriku velikoy Snova!
    3. Re:The same reason there no more anti-war protests by sgt+scrub · · Score: 1

      Where was the "grim milestone" protest for Obama's Obama didn't go tarded and start as many wars as he could.

      In the 70s and 80s, the anti-nuclear crowd was able to spread lots of FUD Yeah. FUD. Because humans never get lazy or forget to expect the unexpected.

      because it helped the left gain political power. Yeah. Because every time there is an anti-nuclear protest it only charges the left.

      --
      Having to work for a living is the root of all evil.
    4. Re:The same reason there no more anti-war protests by nbauman · · Score: 1

      This is the kind of "scrutiny" they're talking about, BTW.

      http://thebulletin.org/web-edition/op-eds/lessons-not-learned-insider-threats-pathogen-research

      Both determined that intrusive monitoring of microbiologists engaged in unclassified research would not necessarily increase protection against insider threats and rejected broad adoption of procedures that scientists and military personnel who work with nuclear weapons and fissile material must endure, such as random testing for alcohol, marijuana, cocaine, or amphetamines; observation of off-duty behavior; video monitoring of laboratory activity; annual psychological assessments; or mandatory privacy waivers to allow supervisors to review mental health treatment records.

    5. Re:The same reason there no more anti-war protests by Anonymous Coward · · Score: 0

      Where are the protestors for the drone war, BTW?

      Most people are aware that a drone isn't morally worse than using a guided missile, a smart bomb, mortars, or artillery.

    6. Re:The same reason there no more anti-war protests by Anonymous Coward · · Score: 0

      Every time I post a message about LFTR reactors someone inevitable says something that is unfounded. Being as impartial a write as possible, I always entertain the arguments by giving them counter arguments which takes a lot of time from research for the defense.

      Yeah, but the real issue with LFTR it will explode, killing millions like in Chernobyl, but we couldn't cover that up here, which is why they need to add flouride to the water in New York, to keep people dazed and unable to share the secret glowing death zone of 3 mile island. Then there's the miollions of years of instantly fatal radioactive waste, unlike clean coal and "natural" gas. Also, nukclear powah causes racoon aids in people, spreading "the gay". Robble robble robble.

    7. Re:The same reason there no more anti-war protests by Kohath · · Score: 1

      Yeah, but the real issue with LFTR it will explode, killing millions like in Chernobyl

      False. Chernobyl didn't kill millions. Stop spreading lies please.

  6. Everyone should be intrusively monitored by Anonymous Coward · · Score: 3, Insightful

    Remember 9/11 folks. That happened because the government didn't have the proper tools to monitor the terrorists before the act occurred mainly due to the idiotic beliefs in an outdated and itself a terroristic document, the constitution. Now that we are moving away from the constitution, which was a piece of crap anyways, the country can be made secure. We now have a solid globalist President that is on board with the abolition of the constitution, especially the second amendment, which will lead us to a socialist global society. It's time to give up your so called 'rights' and get with the program. FORWARD!

    1. Re:Everyone should be intrusively monitored by Anonymous Coward · · Score: 0

      Yeah, I've been hearing that on the radio too, and let I tell you I'm going to invest all my money in gold. We all need to listen more to the people who talk tough and are angry and not wimps and make sure you know that with every sentence that comes out of their mouths!

    2. Re:Everyone should be intrusively monitored by dbIII · · Score: 0

      especially the second amendment

      What? He's taking guns away from the National Guard? Why would he want to shut down a well organized militia?
      Oh that's right, you don't know what you are writing about. Maybe you think that amendment is just about having your guns with no responsibility while others go to fight and die for you. There's more to being a patriot than wrapping yourself in a flag and screaming about toys being taken away.

    3. Re:Everyone should be intrusively monitored by skine · · Score: 1

      I would like you to back up the statements that Obama is on board with 1) "abolishing the constitution, especially the 2nd amendment," and 2) "which will lead us to a socialist global society."

      1) Placing limits on the 2nd amendment isn't abolishing it. Every other amendment from the Bill of Rights has limits that have progressively become more well defined over the last 220 years. The 1st amendment guarantees freedom of speech, yet defamation is illegal. Obama isn't taking your guns. He's saying that we should run background checks on gun purchasers and limit the number of bullets that can be fired without reloading to a number higher than THE standard service rifle during WWII.

      2) How to argue this really depends on your meaning of "socialist global society."

      I would argue that the US became a global society during WWI, and a socialist society during the Great Depression. Over the last 80 years, we've become more global via commerce and war, and the most socialistic bills are the ones that guarantee defense contractors and oil companies free money, not the bill that said "if you get sick before getting insurance, you can still get insurance, but they still don't have to pay if you were sick before you got insurance," nor the ones loaning money to tech and car companies that have mostly been paid back.

    4. Re:Everyone should be intrusively monitored by Anonymous Coward · · Score: 0

      Remember 9/11 folks. That happened because the government didn't have the proper tools to monitor the terrorists before the act occurred mainly due to the idiotic beliefs in an outdated and itself a terroristic document, the constitution. Now that we are moving away from the constitution, which was a piece of crap anyways, the country can be made secure. We now have a solid globalist President that is on board with the abolition of the constitution, especially the second amendment, which will lead us to a socialist global society. It's time to give up your so called 'rights' and get with the program. FORWARD!

      wow, not sure if real or ironic, but every time I read something like this David Bowie's "I'm afraid of Americans" comes to mind.

    5. Re:Everyone should be intrusively monitored by Anonymous Coward · · Score: 1

      1) Placing limits on the 2nd amendment isn't abolishing it.

      Unless it's done by amendment, then yes it is.

      The 1st amendment guarantees freedom of speech, yet defamation is illegal.

      Not exactly - You cannot be arrested and prosecuted for defamation, it's a Civil matter between you and the other party.

      and limit the number of bullets that can be fired without reloading to a number higher than THE standard service rifle during WWII.

      Changing clips takes a few seconds, and with a little practice it can be done in under one second.
      In combat such as in WWII you don't want most of the troops using full-auto weapons and high capacity clips, because they'll burn through all their ammunition on the first target. The purpose of the lower capacity magazine is not to slow down rate of fire, but rather to help break focus of the shooter so he can aquire a new target instead of pumping more rounds into the body he already shot multiple times. The higher capacity clips also have problems in rough combat situations, they are more prone to getting bumped and bent, which causes jamming.

      I would argue that the US became a global society during WWI

      Then you would be wrong, and need to go back and study some History. Pay special attention to the post-WWI isolationist movement and its impact on US and World politics.

    6. Re:Everyone should be intrusively monitored by CrimsonAvenger · · Score: 1

      He's saying that we should run background checks on gun purchasers and limit the number of bullets that can be fired without reloading to a number higher than THE standard service rifle during WWII.

      Did you know that there were standard issue WW2 individual weapons that used 15 round magazines? And 30 round magazines? And 50 round magazines?

      Didn't think so.

      Placing limits on the 2nd amendment isn't abolishing it.

      Which parts of "shall not be infringed" do you have a hard time with?

      Note that the First Amendment only has a prohibition against Congress passing laws restricting....

      --

      "I do not agree with what you say, but I will defend to the death your right to say it"
    7. Re:Everyone should be intrusively monitored by Chrontius · · Score: 1

      I should direct the viewer's attention to the M1 Carbine, which unlike the M1 Garand, had detachable box magazines of up to 30 rounds issued.

      Then they gave it a "fun switch" and called the M2 Carbine, and it was very nearly a modern assault rifle at that point, wanting only for black plastic and modern ergonomics. Actually, the paratrooper version got the modern ergonomics, and a folding stock to boot. It still lacked pointy-nosed, or "spitzer" bullets, which makes them more aerodynamic and increases their range, but wasn't really necessary for the sort of up-close fighting the M1 and M2 was designed for. Sure sucked when someone brought combat to you, I'll bet, but it was a solid design that's still in production for the civilian market, where it's considered a good gun to teach someone to shoot with - it's light, easy to use, and doesn't recoil very hard.

    8. Re:Everyone should be intrusively monitored by Anonymous Coward · · Score: 0

      92% of americans support universal background checks. if 8% of americans are criminally minded, that means the only opponents are criminals or the few idiots who believe in that tea party crap. My car is a lethal weapon. if i hit someone with it, i may lose my license to drive. i must have insurance for it. the second amendment doesnt say firearms. it says arms. and they can be regulated. its there in the first sentence. congress can regulate arms by regulating how militias are formed and what constitutes one. What they cannot do is pass a law forbidding citizens from owning arms, as in "no one can own any weapons, ever". so, lets have a well regulated militia, with each member required to pass extensive background checks, pay for insurance for each weapon they own, pay a tax for excess ammo/guns owned personally, pay dues to the militia, have the weapons and ammos stored in a magazine in the town hall, perhaps where the fallout shelters are.

      Bottom line: the constitution says it must "establish Justice, insure domestic Tranquility, provide for the common defence, promote the general Welfare". where is defense listed as INDIVIDUAL defense? no where. how about the declarationn of independence: "Life, liberty and the pursuit of happiness". it doesnt say: life is not as important as liberty.

      If your "right" to own a gun, collectively interferes the right of 30,000 other citizens to "live", then your right will be necessarily restricted. you cant shout fire in a crowded theatre, you cant own unlimited firepower.

      Remember, those who rail against increased gun regulation are outliers, renegades, philosophically bankrupt, violent, dangerous and evil. just saying.

  7. Great point, and also by Anonymous Coward · · Score: 0

    Why is Jerry Jones still calling the shots in Dallas? The Boys have won exactly one NFL playoff game in the last 16 years. An owner and GM are two separate jobs, Jones is messing up both right now.

  8. Open access leads to better outcomes by Stonefish · · Score: 4, Interesting

    1. Biological agents are readily available.
    2. Biological agents are naturally dangerous ie H5N1 is killing people.
    3. Reseach into these agents will provide positive outcomes. ie vaccines
    4. Stupid measures such as profiles fail the best researchers, eg NSA fails more than 50% of maths researchers. Those creative left handed types are dangerous. It's actually true that NSA employs fewer left handed people than the research community at large and is an acknowledged problem. ;-)
    5. Research doesn't have many resources, wasting them upon dumb controls means much less reseach.
    6 The military has oodles of cash (read wasteful) however they're not allowed to play with biological weapons so biology doesn't get much of this cash. (unlike nukes)

  9. History. by LowlyWorm · · Score: 1

    The reason there is less scrutiny is simply history. Nuclear weapons were used in the last world war. Biological warfare was not used extensively since WWI. It was used in mid evil times and in the American wars against native Americans but biological weapons are more difficult to contain than other weapons of mass destruction and are less widely used for that reason. Also, there are justifiable reasons for biological research in the medical research field that might be severally limited if over-regulation were applied. This is not to say that misuse of biological pathogens is any less deadly.

    --
    Time flies like an arrow. Fruit flies like a banana.
  10. Easy by Mister+Liberty · · Score: 0

    Nuclear rhymes with explosion.
    REAL explosion that is -- not as in outbreak.
    Great sensayional effect,spectacular soundtrack,
    great lightshow, tremendous kinetic surround effects,
    what's not to like?

  11. Re: History (correction) by LowlyWorm · · Score: 1

    Chemical weapons were used extensively in WWI.

    --
    Time flies like an arrow. Fruit flies like a banana.
  12. Spanish Flu by Roger+W+Moore · · Score: 4, Insightful

    Speaking of naive. You're sure of this. Just a 'few sequences' and poof, the end of life as we know it?

    Obviously that seems exceedingly unlikely so to try to cut through irrational fears lets try looking at a real disease. The Spanish flu of 1918 killed 50-100 million people world wide. If we scale that as a percentage of the population today that number would be 180-300 million and that is for a disease which 80-90% of the people who caught it survived. This is clearly comparable to several, powerful nuclear weapons and for something as infectious as flu it is unlikely that you could stop it once it got out e.g. the recent swine flu outbreak.

    So for those involved in researching viruses with the same, or worse, potential as the spanish flu why shouldn't there be similar safe guards to nuclear weapons researchers? The consequences of material getting out is similar in both cases and, in a world with suicide bombers, I'm not sure I'd rely on the fact that a biological weapon may well kill the one who releases it to stop if from happening.

    1. Re:Spanish Flu by Anonymous Coward · · Score: 2

      Because anyone with a decent knowledge of virology could pull an attack off without access to any "restricted" materials, they might not succeed, but if you think that you are secure because you watched the experts you just missed well more than 90% of the risk.

    2. Re:Spanish Flu by Anonymous Coward · · Score: 0, Insightful

      Really? So what? The nuclear weapon not only kills a bunch of people in a spectacular way, it also makes a large area uninhabitable and, of course, destroys the infrastructure too. The flu kills some people. The land is still livable and the buildings, roads, bridges, etc. are all fine. The only thing that happens is the population (which is too high) goes down a bit.

    3. Re:Spanish Flu by __aaltlg1547 · · Score: 4, Interesting

      The consequences of the material getting out are worse with the pathogens because it doesn't take any technical capability at all to start the spread of the pathogen. All a person has to do is get infected, or get another person infected.

      Steal 20 pounds of weapons-grade plutonium and you have 20 of raw material that you need a Ph.D. and a lot of engineering knowledge to convert into a bomb that can kill millions of people.

      Also, the pathogen is millions of times easier to conceal.

    4. Re:Spanish Flu by Roger+W+Moore · · Score: 2, Insightful

      Yes but with the Spanish flu as much as 50% of the world's population was infected so, while a nuclear weapon is limited to killing the people in one city a biological weapon can reach into practically every home on the planet. Those "some people" will include your friends and family so again I would say it seems just as terrible as a nuclear weapon but in a different way.

    5. Re:Spanish Flu by Anonymous Coward · · Score: 0

      The Spanish flu was somewhat special case as the secrecy and censorship during the WW1 caused media to mostly ignore the early signs of the disease, giving the flu great way to spread mostly unnoticed. The other factors where the large population movements and the chlorine gas used in the battlefield.
        It is of course quite telling that the need to monitoring is not very large for those involved with unclassified research. With classified research, the need for intrusive monitoring is apparently high then, which leads to the question of what the virus they are researching at?

    6. Re:Spanish Flu by girlinatrainingbra · · Score: 1

      I loved the Spanish Flu episodes of ReGenesis. That show really captures a lot of intelligence and thoughtful analysis in the midst of crazy and unlikely + unrealistic plot lines. Ellen Page was in it as Sandstrom daughter in the first-season episodes (The Ontario Genomics Institute also wrote a bunch of fact-sheets about the scientific facts behind the fictional story lines. Two of those apply to these concepts. Hell, even Psych did an episode about virulent pathogens, and that episode even starred the Asperger's scientist from ReGenesis, Bob Melnikov (played by Dmitry Chepovetsky): the episode was in 2010 Death is in the Air, which is Psych Season 4, episode 13.

    7. Re:Spanish Flu by Jessified · · Score: 2

      Our ability to identify and quarantine disease is obviously what it was at the beginning of the 20th century. No big breakthroughs since then.

    8. Re:Spanish Flu by Electricity+Likes+Me · · Score: 5, Insightful

      This. The potential "super virus" that was developed a few months back wasn't done with any complex genetic engineering. They just passed it between ferrets for a few generations, and wound up with the most dangerous disease currently imaginable.

      You want a risk factor? Factory farms swimming in our antibiotics of last resort for no good reason.

    9. Re:Spanish Flu by Anonymous Coward · · Score: 0

      No phd needed. Put enough weapons-grade material in one place, such as making a simple pile by hand, and it will explode. The engineers can get a much bigger yield from less material, but so what? A "handmade" nuclear explosion might still get you to 1/10 of the Hiroshima bomb, with lots of nasty fallout. Not what you want in a city of 10 million people.

      A very simple nuke with lumps of stolen uranium at both ends of a pipe, and some dynamite to make the lumps meet in the center, will get you a Hiroshima-strength bomb. Never mind that someone with "Ph.Ds and lots of engineering" can thousand-double that yield with a good H-bomb design. A terrorist with the simplest kind of bomb is too bad already. Unlike a foreign government, a terrorist may not need to "win a war".

    10. Re:Spanish Flu by Anonymous Coward · · Score: 0

      ... start the spread of the pathogen ...

      That is a knife that cuts both ways. Namely, the bio-weapon will spread and my army will catch it. So any pathogen has to be very stable (no mutations), very virulent, and very short-lived. Now that's difficult. There are plenty of stories of a pathogen decimating the planet. eg '28 days later'.

    11. Re:Spanish Flu by dkf · · Score: 1

      Our ability to identify and quarantine disease is obviously what it was at the beginning of the 20th century. No big breakthroughs since then.

      Problem is, the breakthroughs we've made in the past 50 years or so have been in a time with relatively few 'flu-like pandemics. We don't actually know if the breakthroughs will help with anything that infectious. We might be in a good position to deal with it, or that might just be total hubris.

      Well, punk? Do you feel lucky?

      --
      "Little does he know, but there is no 'I' in 'Idiot'!"
    12. Re:Spanish Flu by Roger+W+Moore · · Score: 1

      No big breakthroughs since then.

      Like air travel? Coupled with a higher population density I'm not convinved the net affect of breakthroughs has made containment easier. Again, sticking to real events as a guideline, containment did not work with swine flu did it?

    13. Re: Spanish Flu by Anonymous Coward · · Score: 1

      We may have better medicine, but we also have transit hubs unlike anything in the 1910s. The problem is that infected folks can spread the disease even faster in the period before symptoms appear via air travel.

      And yes, that worry is why we watch new flu strains carefully, like H1N1. But if we miss one on accident? Ouch.

    14. Re:Spanish Flu by HiThere · · Score: 1

      FWIW, I believe that Neutron bombs don't significantly damage the real estate attacked.

      OTOH, there are reported to have been developed diseases that are 100% fatal to exposed individuals. (They were ferrets, not people, but ferrets were chosen because they are immunologically similar to people WRT that disease.) Also, I believe, it was contagious before the first symptoms appeared. (Not that that matters too much, since many companies have employment policies that strongly encourage people to come to work even when they feel sick.)

      --

      I think we've pushed this "anyone can grow up to be president" thing too far.
    15. Re:Spanish Flu by Chrontius · · Score: 1

      My empire for a mod point.

      This guy gets it.

    16. Re:Spanish Flu by AK+Marc · · Score: 1

      That and 1918 flu was in the middle of a world war. So many other things were going on that coordinating a fight against an epidemic was impossible.

    17. Re:Spanish Flu by rioki · · Score: 1

      Except that there is no practicable neutron bomb. All enhanced radiation weapons are basically nuclear bombs with a smaller blast radius. What that equates to is a large area of destruction, a little halo of death and a large area where the bomb did not do much. Most will die of cancer a decade down the row, but can still fight you for their land now and will probably very viciously.

      But then GPs argument is moot on total other ground.

    18. Re:Spanish Flu by __aaltlg1547 · · Score: 1

      Uranium 235 yes. Plutonium no.

  13. Easy.. by Anonymous Coward · · Score: 0

    Because there aren't decades of anti-nuclear propaganda to make people scared of it, just a few novels and sci-fi scenarios, and the medical industry is far better at keeping its nose clean in the public's eye.

  14. Re:Simple, it's because obama... by DigiShaman · · Score: 0

    Obama is not the n word. In fact, his character is refined and he does have a sense of cuth. The problem with Obama is that he's your typical passive-aggressive authoritarian that somehow feels he can get around the law by making it an executive branch issue. Despite the fact communist progressives are toxic to maintaining a harmonious and prosperous culture, the American people voted for these ideal multiple times. Thus I'm reminded that presentation, not substance, matters. Therefore, if it takes being a bullshitter to make it in life, so be it. I can play that game too.

    --
    Life is not for the lazy.
  15. Re:Simple, it's because obama... by Anonymous Coward · · Score: 0

    You don't want to be seen as a 'racist' after all as that's a fate worse than any other.

  16. Re:Simple, it's because obama... by Anonymous Coward · · Score: 0

    Whoever modded OP as insightful should have mod privileges revoked. This is pretty basic.

  17. Hmm by lightknight · · Score: 1

    In the past seventy odd years or so, how many nuclear scientists / chemists / biologists / etc. have gone awol?

    There's your answer.

    --
    I am John Hurt.
    1. Re:Hmm by Samantha+Wright · · Score: 1

      And there's a very good reason for that! A nuclear scientist who defects may justify his or her actions as giving a small country leverage against a bigger one's economic clout. No nukes need to be fired; it's just that (for example) India can't threaten Pakistan with nukes. It's a completely peaceful transfer of power, making it a guilt-free action on the part of the defector.

      With biological weapons, the most dangerous ones are already out there—Malaria, Ebola, et cetera. These are already found in third-world countries, and engineering pathogens can't improve on them much... and for various reasons, they're impractical as a weapon against a developed country like the US; you would do better to send a hitman or nerve gas in most cases.

      Really, there's no such thing as a biological WMD.

      --
      Bio questions? Ask me to start a Q&A journal. Computer analogies available for most topics!
  18. Haha by sargon666777 · · Score: 1

    There is something humorous about the story right below this being a nuclear water containment leak....

    --
    Am I lying when I tell you that im telling the truth? Or am I telling the truth when I say that Im lying?
  19. Anthrax = Weapon of Mass Distraction by damn_registrars · · Score: 1

    Of course, there are plenty of dangerous pathogens that are researched actively in the US and other countries. However, Anthrax for the most part is not one of them. As my undergrad microbiology professor said, Anthrax is a "weapon of mass distraction", as it is of little value in terms of actually causing fatalities. It is incredibly difficult for someone who has caught Anthrax to actually transmit it to another individual. Even when you have spores (such as those that were mailed) it is not easy to actually infect someone with it as the required number of spores to infect someone is highly variable. And on top of that, if it is quickly diagnosed the outcome is usually quite good.

    In other words, you could do almost as much by mailing letters with powdered sugar instead.

    --
    Damn_registrars has no butt-hole. Damn_registrars has no use for a butt-hole.
    1. Re:Anthrax = Weapon of Mass Distraction by Lehk228 · · Score: 1

      anthrax is a biological weapon in that it is a weapon of biological origin, however it's behavior and characteristics are much more similar to a chemical weapon.

      --
      Snowden and Manning are heroes.
    2. Re:Anthrax = Weapon of Mass Distraction by Anonymous Coward · · Score: 0

      Although I am not disagreeing with you about anthrax, the goal of a biological is not necessarily to cause casualties. If you were to use something like a weaponized form of brucella, you would get very few deaths. What you would get is to completely overwhelm the medical resources of a first world country. You also get a country where 75% of its workforce it put out of commission for 1-3 months and anyone who is not infected is too scared to leave their homes. Do you think that might have some useful secondary effects? Like maybe the complete collapse of the economy. People dieing from completely unrelated conditions simply because they are unable to get any medical care. Maintaining adequate protection of the border also because impossible which means you get to walk across with even more bio weapons, or maybe a backpack nuke, or just a few dozen terrorist cells ready to cause trouble when the crisis is finally over..

    3. Re:Anthrax = Weapon of Mass Distraction by sgt+scrub · · Score: 1

      I guess terrorist will have to get cocaine popular before using it. Kinda defeats the whole terror thing when people are all happy and stuff though.

      --
      Having to work for a living is the root of all evil.
  20. simple:pathogens don't go flash/boom by Anonymous Coward · · Score: 0

    Nuclear devices have demonstrated capability to kill many people and cause much damage in a short time.
    Biological/Chemical weapons may have large mortality, but not quickly. Bhopal was smaller than Hiroshima (8k vs 150k). Biological and chemical weapons/accidents do not cause property damage (loss of use, perhaps, in a transient sense "sowing a field with salt")

    The articles (and the ones referenced) describe controls on nuclear workers and ask why bio researchers aren't under similar restrictions, but neglects that the vast majority of people who have capability and knowledge of nuclear info are not restricted in any way.
    The controls on nuclear workers are on the sophisticated end products (the SNM itself, design *details*). There are no real limitations on someone doing nuclear experimentation in their garage or lab other than "occupational safety". Basic design information and, of course, the underlying theory, is in the open literature, and totally unrestricted. It is very possible for someone to come up with a workable design using library materials (demonstrated multiple times, see, e.g. "the N-country problem"). Nuclear weapons are somewhat unique in that the essential materials (fissionable materials) are hard to come by.

    The situation is a bit different for biological weapons. Building a lab in your garage is certainly possible at relatively low cost. The "bench skills" needed aren't hard to acquire and are well within the ability of high school students (look at the International Science & Engineering Fair for examples). (Or Frank Herbert's "The White Plague") The "hard parts" are things like weaponizing (just as the hard part for nuclear devices is in making a small portable bomb), and that's more in the nature of "trade secrets" and should be protected in the same way as design details in the nuclear biz (e.g. security clearances and whatnot).

    Just as in the nuclear field, though, there's a long distance between talented researcher in well equipped university lab and weapons developer. We don't engage in security restrictions on students doing nuclear work.

    It all comes down to the fact that there are LOTS and LOTS of people who possess knowledge of how to cause mass casualties or to cause them directly (the driver of the hazmat truck: we transport millions, if not billions, of tons of hazardous materials every day. A truckload of dynamite has no special precautions, neither does a truckload of phosgene or HF or any of a zillion things). And most people do not do "bad things".

    What about regulating mechanical engineers: they could be designing a high rate of fire machine gun to be mounted on a small private plane re-equipped as a UAV. Or what about aero/astro majors.. they could modify a crop dusting plane to serve as a CBW dispersal vector.

  21. Suggest a reconsideration by ridgecritter · · Score: 1

    because nobody could distribute the daily HF etchant load so as to kill very many people. Contrast that with the Black Death, which killed 1/3 of Europe through the movement of fleas on rats on ships. http://en.wikipedia.org/wiki/Black_Death

    Chemweapons have to be distributed and don't extend their effects very far beyond their delivery locus. Bioweapons can propagate. Engineer a latency between infection and onset of symptoms of say, 100 days into an airborne pathogen with high clinical mortality and watch it spread far and wide before it surfaces.

    I understand that such bioengineering may be nontrivial, but to say that "no biological weapon could ever be as effective as a chemical one" is, I believe, incorrect.

    1. Re:Suggest a reconsideration by Samantha+Wright · · Score: 1

      Engineered bioweapons cannot propagate. Incubation period is inversely proportionate to severity of symptoms, except for complex organisms like protozoans. Bacteria and viruses both mutate too quickly for a delayed lethal phenotype to be in their interest, otherwise we would see this more frequently in the wild.

      The only highly-spread bioweapon (that comes to mind) not defeated by a combination of sanitation and the environment is malaria. Rather crucially, malaria is very common in third-world countries, which means that restricting the activities of researchers provides a uselessly small amount of security.

      --
      Bio questions? Ask me to start a Q&A journal. Computer analogies available for most topics!
    2. Re:Suggest a reconsideration by ridgecritter · · Score: 1

      The inverse correlation between incubation period and symptom severity is what one would expect from successful in-the-wild pathogens. I get that evolutionary processes have given us the pathogen behavior you describe.

      However, I don't think what we currently know is that's all that's possible. I suspect the set of potential (engineerable) pathogenic behavior is broader than what we observe in the wild, and broader than what we currently think probable.

      Your statement "Engineered bioweapons cannot propagate" seems (to me, anyway) unlikely to be valid given the complexity of the systems involved and human creativity. I regard it as only a matter of time, just as the transition from chemical to nuclear explosives was only a matter of the time needed to understand new physics and do the engineering, once the motivation was there. "Cannot" isn't the bet I'd place.

      That said, it's silly to think that intrusively monitoring bioresearchers will help anyone but the security theater types. It will only add friction that will delay beneficial applications of the research.

       

    3. Re:Suggest a reconsideration by Samantha+Wright · · Score: 2

      I've put up the explanation in another comment, but the gist of it is this: the DNA in bacteria and viruses evolves to do whatever is necessary to survive. If you do not set it up so that your construct is vital to the cell's survival, it will drop that functionality within a few days to a week of propagating in the wild. Viruses have been very frustrating to use for controlled engineering tasks like gene replacement because they tend to kill more target cells (without replication) than they transfect, and because viral genomes are so unstable, anything not immediately vital to its function will be gone by the time it's left the host. You'd be better off poisoning the target(s) with Polonium.

      Bacteria take a little longer to screw everything up, but they have their own problems, in that they're pernicious gene-exchangers. The majority of genes in any given bacterium can be found in most of the other species from the same environment; this strategy has allowed them to defend against unexpected stressors like antibiotics and plant chemical defences (allelochemicals). As a result, either the payload will be dead in a week or two (a problem that has often marred many good iGEM projects), or on the off-chance it's actually useful, you can expect it to have spread around the world in a few years. That's great for rogue madmen, but an impediment to goal-oriented terrorist organisations and nation states.

      --
      Bio questions? Ask me to start a Q&A journal. Computer analogies available for most topics!
  22. bunch of reasons by stenvar · · Score: 1

    (1) People have an irrational fear of radiation and anything "nuclear".

    (2) It's damned hard to create a deadly pathogen that's any worse than what already is out there.

    (3) Radioactivity is trivial to detect, new pathogens are pretty much impossible to detect, so it's hard to "scrutinize" the work.

  23. "Safe" and "dangerous" strains look the same. by Anonymous Coward · · Score: 0

    Can you tell the difference between a bacteria that is pathogenic and one that is safe with video surveillance? No.

    How many virulence factors does a "safe" strain need to be a harmful strain? Probably 1-3 in the case of bacteria (such as Anthrax's capsule and toxin) and 1-2 for a virus (one human gene added can make a vaccine useless).

    How many people are already dying from pathogens that are freely available?

  24. why do Financial Executives face less than either? by darue · · Score: 1

    Let's snoop on everyone! Or we could just establish real world precautions that prevent people from smuggling anthrax out of labs and that sort of thing.

  25. Bio is hard because it's all been done: by Hartree · · Score: 2

    "expert panels have concluded that there is no need for intrusive monitoring of microbiologists engaged in unclassified research."

    For good reason.

    First, the knowledge is more widespread.

    We have large numbers of researchers/lab workers/hospital lab techs that could do the neccesary techniques for much of biological work.

    We have to have them in large numbers to keep us safer from the NATURAL bioweapons we face every day.

    Such well known killers as malaria, bacterial pneumonia, a whole range of virii, the various strains of antibiotic resistant bacteria we keep a running treadmill race going with, etc, etc.

    Putting all of these lab/hospital workers (Yes, they are working with pathogens. Why else do you think they're doing culturing of that throat swab your doctor took?) under a magnifying glass is needless, discouraging to those who might enter the field, and actively disruptive to trying to fight disease.

    Second, nature completely outclasses us.

    Someone in a lab can do one experiment every few days/weeks, maybe. Mother nature can and does do billions to trillions of experiments all in parallel.

    The bioweapon arms race has been going on in nature for billions of years (yes, billions. Single cell life has been around that long and competing. Multicelled life and armor/teeth is a latecomer at 600 million or so). Every nasty trick you're likely to think of to put into your superbug has been tried multiple times naturally.

    The metallo-beta-lactamases that are the hot new nasty in antibiotic resistance? They aren't new. They were old genetic material that were present in a minority of bacteria, and then spread due to it being an advantage for some bacteria in some cases. None of the antibiotic resistance we see is "new". It's all relics in the bacterial genomes that have become useful again. Why? Because Mom Nature already tried those tricks.

    And,it's the same for virii or any other one you can think of.

  26. "Nuclear" sounds dangerous. It's just bad P.R. by girlinatrainingbra · · Score: 3, Insightful

    It seems like it's mostly because of bad PR for the word "nuclear". The sciency types here on /. know that nuclear power plants are not as dangerous as other types of power plants, yet the majority of the public is against nuclear power systems. The PR for "nuke" is so bad that it even caused medical types to change the name of one of their diagnostic devices:
    .
    MRI machines (magnetic resonance imaging) are called that because when they called them NMR machines originally, people were afraid of the word "nuclear" in Nuclear Magnetic Resonance. Even though MRI machines are still exactly the same thing and still measure nuclear magnetic resonance, they no longer use the word "nuclear", because no one wanted to be stuffed in a tube of a machine that had "nuclear" in its name!! People confused it with nuclear imaging in which radioactive isotopes really are injected into the human body and then imaging is performed to see how the isotope is distributed and if it clusters in certain parts of the body.
    .
    People are scared of "nukes", and not-so-much of teeny little microbes, though look at all of the wacky episodes of ReGenesis, a canadian show about the canadian equivalent of the CDC and a genomics lab, to see the crazy plotlines of what could go wrong with bio-organisms. Psych also did an episode, "Death is in the Air", Season 4, Episode 13, that used "Bob" from Regenesis as the same sort of scientist. See my other post here for links to those episodes.

  27. because bioweapons don't cause property damage by Anonymous Coward · · Score: 0

    the 0.1% are more concerned about property than lives and they control legislation and regulation
    Nuclear weapons destroy buildings and other capital assets.

    Bioweapons kill people, but those are easily replaced, at lower cost. Dead people don't require paying pension benefits.

    Destroyed factories require rebuilding at substantial expense.

    1. Re:because bioweapons don't cause property damage by tloh · · Score: 1

      Not so in the case of intellectual property. Imagine corporate black ops where a company eliminates a competitor by ensnaring their key employees with hookers loaded with chlamydia that has been weaponized with a fatal payload.

      --
      Stay sentient. Don't drink bad milk.
  28. well, duh by Goldsmith · · Score: 1

    Intrusive regulation "may" discourage infectious disease research? Of course it would. It has done just that for (non-medical) nuclear research.

    We sent a UCLA professor to jail when a student in his lab died in an accident related to poor training. Maybe that's the right idea.

    If a deadly accident or malicious release occurs from your lab, you go to jail. Just reiterate that to everyone: you're ultimately responsible for what comes out of your lab. It's a lot less harsh than the permanent label you earn as a terrorist and an enemy of civilization for a nuclear mistake.

  29. Don't fear it, sing it! by servognome · · Score: 1

    There was a little Spanish Flu
    A deadly pathogen you know
    He'd heard of microbes like Tetanus
    Malaria spread by mosquitos
    Why not a little Spanish Flu

    --
    D6 63 0D 70 89 81 BB 8E 7B 7C 5F 5D 54 EA AB 73
  30. Wired had a good article on Anthrax by witherstaff · · Score: 1

    The Wired Article : Anthrax Redux: Did the Feds Nab the Wrong Guy? makes me wonder if the anthrax mailer got away with it. Also the Wiki article says one of the 19 involved in 9/11 may have had anthrax based on a doctor which I had never heard before.

    1. Re:Wired had a good article on Anthrax by flayzernax · · Score: 1

      I find it odd that with the prevalence of things like anthrax in the wild in 3rd world countries that the Anthrax Mailer cases were such isolated incidents and that only one "terrorist" out of so many bothered to put in the effort. You would think that if there was a real serious problem in this regard we'd be seeing incidents like this on a yearly, if not at least bi-yearly basis.

      This makes me think that the whole incident better explained as a conspiracy to produce propaganda and FUD. Of course thats pure conjecture. But I'm one of those dip shits who likes to trust their intuition and logic over what the news media spews forth on a daily basis.

      Then again it could have just been one wacko's response to one isolated incident (9/11)... That works if you fully trust Occom's razor. It is the most simple answer.

      But it is enough to make me question what I see and hear on the news and in "official reports".

  31. Don't have to target humans by Anonymous Coward · · Score: 0

    I don't think anyone's mentioned this yet, wouldn't an easier way to bio-screw up a country be to target it's main food crop? They're pretty much monocultures so if you can bypass their resistance then nothing's going to survive, I imagine it'd be easier to infect static fields of wheat than a specific human population.

    Added bonus is that the evil biologist won't be at risk himself, he can fly back to evil country before the food riots start.

  32. Don't worry! by Sqr(twg) · · Score: 1

    The trustworthy people in the physics department always have a suitcase nuke on standby, in case the microbiologists get unruly.

  33. Real Reason by Stonefish · · Score: 1

    The real reason that people in nuclear establishments undergo extensive screening relates more to a cold war philosophy than public safety. They're just making sure that you don't sell those secrets to the Reds.

    1. Re: Real Reason by LowlyWorm · · Score: 1

      I agree. I understand the Russian biological weapons program was far larger than we originally suspected though. I think the reason it was not more widly publicized and feared is that th UN has always been more concerned with nuclear threats.

      --
      Time flies like an arrow. Fruit flies like a banana.
  34. Proliferation, not Research, is the issue by Shoten · · Score: 1

    I hear everyone arguing about what a scientist could produce, and how, and how bad it could/would be...but that isn't the issue at all here. If you're going to talk about nuclear technology vs. pathogen technology, then you need to talk about proliferation. The treaties at stake, the classification of information, export controls...none of these are about *doing* research, they're about the control of knowledge needed to do research. The controls on nuclear research and engineering are about proliferation, about containment of what is known rather than direct prohibition of learning more or experimenting by people who are not in the trusted circle.

    Here's the problem: what's needed in terms of expertise to make effective (more on that word in a moment) nuclear weapons is only known to a relatively small and contained population of scientists. But what's needed to do the kind of research which is feared here on the pathogen side of things is, quite simply, not. You could make all kinds of arguments about why this is, but the fact of the matter is that the horse has left the barn (or whatever the rural metaphor is) with regard to the issue of proliferation on the biological side of this. Maybe it's because of organizations like Biopreparat and what happened when it disbanded, maybe it's because dangerous pathogens have always existed naturally (unlike nuclear weapons or, for that matter, any of the key materials used to build them). Maybe it's because there's a genuine value to the public good for many people to study how pathogens work...and ironically, the nastier the pathogen, the more the public good is studied by intensive and widespread study.

    But however you slice it, you can't restrict sharing knowledge nor the research methods around pathogen-focused microbiology now. And even if you could, restrictions on either sharing knowledge or generating new knowledge through research would inevitably cause unintended consequences because you would also hamstring benevolent research that seeks to do things like develop vaccines and decipher previously unknown pathogens like SARS.

    --

    For your security, this post has been encrypted with ROT-13, twice.
    1. Re:Proliferation, not Research, is the issue by Anonymous Coward · · Score: 0

      So, what do we do? Suppose North Korea releases the 'mutually assured destruction super bug'. What the fuck do we do? Quarantine? Generic anti-virals? Cryo? Bunkers? Escape pods to mars?

  35. The problem is one of control. by Anonymous Coward · · Score: 0

    It is easy to make a nuclear device that kills exactly everyone you hate, and no one else. It is not possible to make a pathogen that kills only your enemy. So while a revolutionary may like the taste of nuclear winter, only a true cartoonish supervillian will deal in a weapon that can easily kill himself.

    1. Re:The problem is one of control. by Anonymous Coward · · Score: 0

      Well, not exactly everyone you hate, as you state here, but disproportionally those that are the targets. You actually make a good point here and this post deserves to be marked up. With things like guns, explosives, and even vehicles and airplanes being flown into buildings, those attacks are more targeted (ie: towards upper class individuals or towards individuals of a certain race or religion or whatever). Even a suicide bomber has the agenda of disproportionately killing one group of people over another, if an attack kills his friends (ie: those of his race, religion, etc...) in equal proportions as his enemies then there is no point as this doesn't hurt his enemies any more than his friends and so his side doesn't gain a relative advantage. Bio weapons don't necessarily discriminate as much, the net outcome is much less predictable ahead of time (lab experiments may not tell you how this pathogen is going to spread once released in the wild) you may release a bio weapon in one country and all of a sudden it could reach your home country and kill your friends (esp in this day and age of international travel). A bomb can be targeted to attack the people residing at a specific location at a specific time.

  36. Knowing Cheney... by Anonymous Coward · · Score: 0

    That inside job likely had approval.

  37. Cow problems don't need a Ph.D. by Anonymous Coward · · Score: 0

    Steal 20 pounds of weapons-grade plutonium and you have 20 of raw material that you need a Ph.D. and a lot of engineering knowledge to convert into a bomb

    That is not the slightest bit correct. Like mots technical things, it is a smart cow problem. Practical designs for 'basic' nuclear weapons are well known. You can even get a t-shirt with one such design. It is the acquirement of material and enrichment processes that are hard.

  38. I'll attach this here.. by Anonymous Coward · · Score: 1

    I'm attaching this here instead of under a more relevant OP, because otherwise it will quickly be buried.

    I have a few family friends that have done work for the government (biology-related, the sort of "let's figure this out before somebody else does so we can combat it if it ever gets released into the air" sort of work), and one of them is now retired. He left because he eventually found out what they were using his work for. I can safely say that the government keeps _very close_ tabs on these guys, and they face a TON of scrutiny. I don't know who this guy is that wrote this article, but it's complete codswallop. If you work on anything remotely dangerous in this field, the kind of thing our government actually takes seriously, they will keep tabs on you, very close tabs, and they'll never let you out of their sight unless they absolutely can't help it.

  39. '01 Anthrax attacks NOT shown to be an inside job by McGruber · · Score: 1

    The second paragraph of the linked article makes this bogus assertion:

    Since 2008, when investigators led by the FBI's Washington Field Office identified Bruce E. Ivins, an Army civilian research scientist, as the sole perpetrator, the collective response has been to minimize discussion of the problem, indulge in wishful thinking, and enact cosmetic changes.

    Here is a Wednesday, Feb 16, 2011 article by Salon's Glenn Greenwald, titled "Serious doubt cast on FBI’s anthrax case against Bruce Ivins - A scientific panel concludes the Government overstated its genetic evidence against Bruce Ivins": http://www.salon.com/2011/02/16/ivans/

  40. We Measure Short by b4upoo · · Score: 1

    We have no ability at all to predict whether a person will strike out or not. The notion that we can watch, predict, or stop bad actors is a fantasy.
                            First we have no way to determine if an individual is acting on his own impulses or is being coerced. A family member could be held by terrorists for example. We also have big problems spotting people with abnormal levels of greed who might be bribed. Follow that up with the fact that we have found no way to determine whether a person simply is the type to want to commit mass murder.
                            Yet somehow our rather limp response is to pass laws, form panels, hire some people, and waste tax dollars trying to prevent things which will surely happen from time to time.
                            This mentality is rather like the chumps who walk into a casino and just keep gambling. The more you participate in the gambling the more certain your failure. The more money we toss down the rat hole of predicting anti-social acts the more we will lose until some technology is born that will aid us.

  41. NBAF by ThatsNotPudding · · Score: 1

    Probably the same line of reasoning that will be moving a disease lab from an island to the campus of a centrallly-located public university (also within eyesight of the stadium, coliseum, and rec center): greed and pork-barrel politics.

    http://en.wikipedia.org/wiki/National_Bio_and_Agro-Defense_Facility

  42. All i've got to say is... by messymerry · · Score: 1

    12 Monkeys Damn the taxpayers, full speed ahead...

    --
    Dear Microlimp: I give you 2 valid product keys for win7 and you reject both of them. Piss off you wankers!!!
  43. Prove it! by Anonymous Coward · · Score: 0

    I am an actual practicing biologist in academia at a major research institution...

    Screenshots, or it didn't happen.