Newsflash: Northern Europe is still capitalist. "Capitalism" isn't tempered - most things are still privately owned and individuals own capital; "laissez-faire" policies are. Social safety nets exist. All of that is still compatible with capitalism. Take your bullshit elsewhere.
Saying Cuba has a lower infant mortality rate than America is misleading. America and Cuba use different standards for determining what counts as a live birth. America's is more strict - essentially, if it comes out and can breathe, it's a live birth. Cuba - and most of Western Europe - automatically count births younger than a certain age (varies a bit by country) or under a certain weight as stillborn unless they actually survive.
The best single change the US could make right now would be to let Medicare and Medicaid negotiate with drug companies over prices, like the single payer systems in Europe can. Until that happens, very little will change healthcare costs in America.
4% unemployment is better than most of Europe. I've been to Columbus. I've been to Berlin and Frankfurt too, and - besides the German cities being somewhat cleaner in the well-traveled areas - there wasn't otherwise much difference, in my experience. But your experience isn't any more valid than mine is.
You had some good thoughts - but influenza uses RNA as its genome. While there are probably Cas versions that cut RNA, I don't think anybody has isolated or characterized them yet. Flu also replicates pretty fast, and I think any CRISPR system that could keep up would have a lot of off-target effects. You're right that getting into cells is another major challenge - you'd need to have this in a lot of cells that could become infected.
Your first example is so completely off base I'm not even sure how to respond, but I'll give it a shot. Parts of the US Constitution do only apply to American citizens, and the Constitution always only applies within American borders. The First Amendment and free speech are not the same thing, however.
I am aware. The fact that executions do occur does not mean they are glorified, and properly administered, there is no "flipping around". When it's done properly, loss of consciousness is extremely quick and death occurs within ten minutes. Now, it certainly doesn't always go as it should, but mistakes don't appear to be common. Stealing a chocolate bar 3 times does not result in a life in solitary.
No, normally we go by easily observable physical characteristics. If I see someone with a beard, I'll probably say "he" without first looking at a karyotype.
Yeah, trans people do have a lot of mental illness; I was under the impression that suicide rates do drop after surgery and hormones, but not to the level of the general populace. If you have seen something that says they don't change, I'd be interested in seeing it.
It's unreasonable for society to expend a lot of effort cater to delusions. But changing the pronouns you use for a person is such a low level of effort (assuming they are asking for real pronouns, not "bunself" or whatever BS the kids on Tumblr are using these days) that I think it's a reasonable request that you at least try.
How does the US think free speech stops at its border? The US has more free speech protections than pretty much any other country, because most other countries think "hate speech" isn't protected speech. The US does not glorify in executing people, let alone doing it slowly. "Never keeps its word" is strong and demonstrably false.
If that's what space was, then there wouldn't be much of an economic case (satellites are pretty useful economically though). But I think you're forgetting about a) raw materials, from the moon, Mars, asteroid belt, etc., b) technologies developed for space exploration often can be repurposed to useful, economically beneficial use on Earth, c) tourism.
Yep, I'm aware (also in the field) - that's why I suggested doing it in combination with a shock and kill approach where you pharmacologically reactivate the latent HIV reservoir, introduce CAR T cells to kill infected cells, and use lenti delivering the CRIPSR system - either to knock out HIV genomes or CCR5 (or both - luckily gRNAs are pretty small!). Off-target effects can be somewhat mitigated with the newer versions of Cas9 - Keith Joung is doing some particularly interesting work there.
Yeah, there's definitely more work to be done on the public health side. A vaccine that actually works would help a lot.
Are chromosomes really what we want to base pronouns off of? There's evidence that the brains of transgender people more closely resemble brains of the gender they identify with rather than what their chromosomes would say. And while they won't completely be able to transition biologically, they can do enough so that the differences are unlikely to come up in everyday life. Frankly, while it's not something I really understand or experience, it also doesn't hurt me in any way. Gender dysphoria sounds awful, and the best way we have to treat it at the moment is hormones and surgery.
So there are a couple options here. One is to actually modify an HIV genome to include the CRISPR/Cas system they used here, and use that as the delivery vector. You can also combine that with a shock and kill treatment - possibly using chimeric antigen receptor (CAR) T cells. It's not going to be cheap or easy, but this is an additional tool.
No, OP is flabbergasted that it works well enough in an actual animal to eliminate integrated HIV copies. Plenty of things work well in isolated cells or tissues that fail to translate to animal models. Efficient delivery is usually a lot harder in animals than in cells.
It'll almost certainly be cheaper long-term than HAART cocktails, but an effective HIV vaccine would do a lot more to end AIDS. Ideally, we'll get both a cure and a vaccine in the near future.
IIRC, this CRISPR/Cas system shouldn't require individualized patient sequencing. HIV does have highly conserved regions of its genome, and disrupting those is enough to render the proviral genome completely non-functional.
Most viruses don't integrate into the host genome like HIV does. This system would not be useful for treating any virus that doesn't use DNA (like, say, the flu) and it would likely not even do very much against most viruses that do use DNA at some point in their replication cycle.
I would also like to see a citation that any materials the Chinese passed out contained things that Leonardo eventually got credit for. I'm well aware that they sent fleets out (not around the globe, but certainly at least to parts of Africa and the Middle East), but I doubt they included reference materials of that nature. Feel free to prove me wrong though, that would be interesting.
IMO, the term "engineer" should not have a legal meaning. "Professional Engineer" or "Certified Engineer" (or something similar) should, but the term "engineer" itself is too broad to be restricted legally.
Slashdot Mirror
Newsflash: Northern Europe is still capitalist. "Capitalism" isn't tempered - most things are still privately owned and individuals own capital; "laissez-faire" policies are. Social safety nets exist. All of that is still compatible with capitalism. Take your bullshit elsewhere.
Saying Cuba has a lower infant mortality rate than America is misleading. America and Cuba use different standards for determining what counts as a live birth. America's is more strict - essentially, if it comes out and can breathe, it's a live birth. Cuba - and most of Western Europe - automatically count births younger than a certain age (varies a bit by country) or under a certain weight as stillborn unless they actually survive.
The best single change the US could make right now would be to let Medicare and Medicaid negotiate with drug companies over prices, like the single payer systems in Europe can. Until that happens, very little will change healthcare costs in America.
4% unemployment is better than most of Europe. I've been to Columbus. I've been to Berlin and Frankfurt too, and - besides the German cities being somewhat cleaner in the well-traveled areas - there wasn't otherwise much difference, in my experience. But your experience isn't any more valid than mine is.
Yeah, that's why charities never get anything done!
If your proposed tool for dealing with it is censorship, then yeah, I can see why they'd say that.
Oh, FFS. Rape is not a pre-existing condition. The AHCA is bad enough without spouting a bunch of BS about it.
You had some good thoughts - but influenza uses RNA as its genome. While there are probably Cas versions that cut RNA, I don't think anybody has isolated or characterized them yet. Flu also replicates pretty fast, and I think any CRISPR system that could keep up would have a lot of off-target effects. You're right that getting into cells is another major challenge - you'd need to have this in a lot of cells that could become infected.
When you say "used to" - did it go away for some reason?
Your first example is so completely off base I'm not even sure how to respond, but I'll give it a shot. Parts of the US Constitution do only apply to American citizens, and the Constitution always only applies within American borders. The First Amendment and free speech are not the same thing, however.
I am aware. The fact that executions do occur does not mean they are glorified, and properly administered, there is no "flipping around". When it's done properly, loss of consciousness is extremely quick and death occurs within ten minutes. Now, it certainly doesn't always go as it should, but mistakes don't appear to be common. Stealing a chocolate bar 3 times does not result in a life in solitary.
No, normally we go by easily observable physical characteristics. If I see someone with a beard, I'll probably say "he" without first looking at a karyotype.
Yeah, trans people do have a lot of mental illness; I was under the impression that suicide rates do drop after surgery and hormones, but not to the level of the general populace. If you have seen something that says they don't change, I'd be interested in seeing it.
It's unreasonable for society to expend a lot of effort cater to delusions. But changing the pronouns you use for a person is such a low level of effort (assuming they are asking for real pronouns, not "bunself" or whatever BS the kids on Tumblr are using these days) that I think it's a reasonable request that you at least try.
Ah yes, that old boogeyman. I can't believe how many people still care about a dead hashtag.
How does the US think free speech stops at its border? The US has more free speech protections than pretty much any other country, because most other countries think "hate speech" isn't protected speech. The US does not glorify in executing people, let alone doing it slowly. "Never keeps its word" is strong and demonstrably false.
If you make it an SNL skit, then it wouldn't work in real life.
If that's what space was, then there wouldn't be much of an economic case (satellites are pretty useful economically though). But I think you're forgetting about a) raw materials, from the moon, Mars, asteroid belt, etc., b) technologies developed for space exploration often can be repurposed to useful, economically beneficial use on Earth, c) tourism.
Yep, I'm aware (also in the field) - that's why I suggested doing it in combination with a shock and kill approach where you pharmacologically reactivate the latent HIV reservoir, introduce CAR T cells to kill infected cells, and use lenti delivering the CRIPSR system - either to knock out HIV genomes or CCR5 (or both - luckily gRNAs are pretty small!). Off-target effects can be somewhat mitigated with the newer versions of Cas9 - Keith Joung is doing some particularly interesting work there.
Yeah, there's definitely more work to be done on the public health side. A vaccine that actually works would help a lot.
Are chromosomes really what we want to base pronouns off of? There's evidence that the brains of transgender people more closely resemble brains of the gender they identify with rather than what their chromosomes would say. And while they won't completely be able to transition biologically, they can do enough so that the differences are unlikely to come up in everyday life. Frankly, while it's not something I really understand or experience, it also doesn't hurt me in any way. Gender dysphoria sounds awful, and the best way we have to treat it at the moment is hormones and surgery.
CRISPR has potential applications for flu research, certainly. But it won't be useful as a flu therapeutic, which is what I said.
So there are a couple options here. One is to actually modify an HIV genome to include the CRISPR/Cas system they used here, and use that as the delivery vector. You can also combine that with a shock and kill treatment - possibly using chimeric antigen receptor (CAR) T cells. It's not going to be cheap or easy, but this is an additional tool.
No, OP is flabbergasted that it works well enough in an actual animal to eliminate integrated HIV copies. Plenty of things work well in isolated cells or tissues that fail to translate to animal models. Efficient delivery is usually a lot harder in animals than in cells.
It'll almost certainly be cheaper long-term than HAART cocktails, but an effective HIV vaccine would do a lot more to end AIDS. Ideally, we'll get both a cure and a vaccine in the near future.
IIRC, this CRISPR/Cas system shouldn't require individualized patient sequencing. HIV does have highly conserved regions of its genome, and disrupting those is enough to render the proviral genome completely non-functional.
Most viruses don't integrate into the host genome like HIV does. This system would not be useful for treating any virus that doesn't use DNA (like, say, the flu) and it would likely not even do very much against most viruses that do use DNA at some point in their replication cycle.
Thanks - I assume you mean for solar panels, yeah? Is the remainder dangerous or is it reasonable to treat it like normal trash?
I would also like to see a citation that any materials the Chinese passed out contained things that Leonardo eventually got credit for. I'm well aware that they sent fleets out (not around the globe, but certainly at least to parts of Africa and the Middle East), but I doubt they included reference materials of that nature. Feel free to prove me wrong though, that would be interesting.
IMO, the term "engineer" should not have a legal meaning. "Professional Engineer" or "Certified Engineer" (or something similar) should, but the term "engineer" itself is too broad to be restricted legally.