For $DEITY's sake why must the 'agency remain neutral'?
It's the "politically correct" crowd's favorite underhand tactic for silencing any opposition. Where have you been the past 5 years or so? God, no wait, Heaven, no wait, HIGHER POWER forbid that anyone have an OPINION about something anymore. Apparently using your brain opens you to being labeled as a bigot. Anyway, enjoy your Christmas umm Holiday umm End of Year festivities.
Speaking as a doctor I will point out the difference for you.
if we're talking about oximes - we're talking about carbamate/organophospate poisoning. These chemicals interact with an enzyme called acetyl cholinesterase, present in the synapses of nerves. As you probably know/remember, acetyl choline is a key neurotransmitter in the brain and the parasympathetic nervous system, as well as the terminal motor connection. When these poisons are applied, they reversibly (carbamates) or irreversibly (organophosphates) bind to acetyl choline and inhibit it.
What this does is prevent the breakdown of acetyl choline in the synapses and terminal motor plate, resulting in excessive parasympathetic stimulation (blood pressure drop, sweating, mucosal secretion, etc), muscular paralysis, and CNS effects. But it's the muscular paralysis (especially the respiratory muscles) that kill you.
Now, what atropine does is bind to acetyl choline receptors. The idea here is that if I have more acetyl choline in the synapse but block the receptor, then the neurons won't be stimulated as much (because the receptors are blocked even if the neurotransmitter concentration is through the roof). This works in cases of mild intoxication (such as carbamates, where the inhibition of acetyl choline is reversible and will decrease over time). This does NOT work with organophosphates (because the enzyme is junked and new enzyme needs to be synthesized, which will take days/weeks).
Now oximes, which have been around for a while, are compounds that are capable of breaking off the organophosphate from its binding site on acetyl cholinesterase. As far as I recall when I studied medicine a few years ago, this only worked within the first few hours of intoxication, because the newly bound protein eventually went a structural reconfiguration which made the process irreversible. However if these scientists have come up with an oxime that is capable of undoing the damage even after the conformational change of the protein, this is newsworthy indeed.
1. the state or condition of being insurgent. 2. insurrection against an existing government, usually one's own, by a group not recognized as having the status of a belligerent. 3. rebellion within a group, as by members against leaders.
Funny, the partisans in Iraq are rebelling against a foreign occupier, not their own government. However in the US the word "insurgent" has become the same as "terrorist"...
Oh mod me offtopic, but Iraq has had me sick for the past 4 years. How long did WW2 last again?
Even in the USA, I'd love to see how they explain the general overall decrease in violent crime since the 1990's, when comparing it to the proliferation of freely available, abundant pornography (internet) and video game consoles with violent games during that same time period.
I think you're the same asshole who goes around whining when people say "Micro$oft" and "Winblowz" too, aren't you? Well I have news for you - take your politically correct agenda and SHOVE IT UP YOUR ASS. People will express themselves however they damned well please, and no one gives a shit about your whining. MAFIAA has been used for YEARS on slashdot, and it's not your sniveling that is going to change it. Have a nice day. Dunbal.
Oh the whackos are good at piracy. My ex wife is a right wing Christian loony evangelical umm I ran out of adjectives, anyway, I remember her spending hundreds of dollars buying CD's loaded with Christian music - every single one of them a pirated copy.
But I guess if you're doing "god"'s work, it doesn't matter if you rip people off. Funny how the pastor drove a mercedes and the wife was always going around in gucci and luis vuitton stuff, though. Especially in this poor country.
Seriously, that's the choice in many situations - crazy meth'd-up homeless guy charges cop with knife...cop tases or cop shoots. Which do you prefer?
OK, how about "guy starts arguing about a speeding ticket". Now is this situation worth risking the person's life using the potentially lethal taser? How about this guy, who was rude and stole a microphone? Yes, let's risk his life too. Or howaboutthese incidents?
Police need to be aware that every time they use a taser there is a small but REAL chance that they will kill the person they are shooting. Therefore they should be a lot more hesitant before using them than they are today. If as a doctor I perform a procedure on a patient without considering (and informing him of) the risks involved, I am liable for murder if the patient dies. The police should also be accountable, just like when draw their weapons - they need a VERY good reason to do that.
it's not just people in Britain that are experiencing the problem, but people in all parts of the UK.
OK I'll buy the England != UK bit, but Britain, ie "Great Britain" includes Scotland and Wales. That's why it's "The United Kingdom of Great Britain and Northern Ireland".
What about numerous UFO observations, Loch Ness etc? are you suggestion those should be regarded as proof of existence since there have been numerous observations and murky photographs? Science works by being skeptical, yes it can take decades for something to be acknowledged and that might be bad but taking every observation as proof would be worse.
Especially since the original perpetrator of the "Loch Ness Monster" hoax publicly admitted to it about 20 years ago in the UK, just before dying. Along with his admission was an apology, and what made him cough up the truth was seeing all the boats gathered with sonar equipment to finally, once and for all, put this myth to rest. He said he was ashamed that so many people had invested so much money for this.
But people love to believe bullshit, and even though this made the news in the UK at the time (I watched it), people still perpetrate the "Loch Ness Monster" BS. Don't even get me started on UFOs.
German development of submarine warfare to counter their superior navy being the second
Germany rarely used their u-boats to attack the Royal Navy, and almost every time they did they got sunk for their trouble. The u-boats were commerce raiders, from the start.
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No. At least not until you stop invading countries and acting like complete assholes.
Texas, it's the new Kansas.
But don't worry, the Flying Spaghetti Monster will soon caress that state with His Noodly Appendage also. RAmen.
For $DEITY's sake why must the 'agency remain neutral'?
It's the "politically correct" crowd's favorite underhand tactic for silencing any opposition. Where have you been the past 5 years or so? God, no wait, Heaven, no wait, HIGHER POWER forbid that anyone have an OPINION about something anymore. Apparently using your brain opens you to being labeled as a bigot. Anyway, enjoy your Christmas umm Holiday umm End of Year festivities.
Try to go to an airport in the US wearing this stuff and you will probably be arrested/tasered for being a "terrorist".
correction (for not proofreading), last line of first paragraph - the poisons bind to acetyl cholinesterase, not acetyl choline. Sorry, it was a typo.
Speaking as a doctor I will point out the difference for you.
if we're talking about oximes - we're talking about carbamate/organophospate poisoning. These chemicals interact with an enzyme called acetyl cholinesterase, present in the synapses of nerves. As you probably know/remember, acetyl choline is a key neurotransmitter in the brain and the parasympathetic nervous system, as well as the terminal motor connection. When these poisons are applied, they reversibly (carbamates) or irreversibly (organophosphates) bind to acetyl choline and inhibit it.
What this does is prevent the breakdown of acetyl choline in the synapses and terminal motor plate, resulting in excessive parasympathetic stimulation (blood pressure drop, sweating, mucosal secretion, etc), muscular paralysis, and CNS effects. But it's the muscular paralysis (especially the respiratory muscles) that kill you.
Now, what atropine does is bind to acetyl choline receptors. The idea here is that if I have more acetyl choline in the synapse but block the receptor, then the neurons won't be stimulated as much (because the receptors are blocked even if the neurotransmitter concentration is through the roof). This works in cases of mild intoxication (such as carbamates, where the inhibition of acetyl choline is reversible and will decrease over time). This does NOT work with organophosphates (because the enzyme is junked and new enzyme needs to be synthesized, which will take days/weeks).
Now oximes, which have been around for a while, are compounds that are capable of breaking off the organophosphate from its binding site on acetyl cholinesterase. As far as I recall when I studied medicine a few years ago, this only worked within the first few hours of intoxication, because the newly bound protein eventually went a structural reconfiguration which made the process irreversible. However if these scientists have come up with an oxime that is capable of undoing the damage even after the conformational change of the protein, this is newsworthy indeed.
From Dictionary.com
1. the state or condition of being insurgent.
2. insurrection against an existing government, usually one's own, by a group not recognized as having the status of a belligerent.
3. rebellion within a group, as by members against leaders.
Funny, the partisans in Iraq are rebelling against a foreign occupier, not their own government. However in the US the word "insurgent" has become the same as "terrorist"...
Oh mod me offtopic, but Iraq has had me sick for the past 4 years. How long did WW2 last again?
Even in the USA, I'd love to see how they explain the general overall decrease in violent crime since the 1990's, when comparing it to the proliferation of freely available, abundant pornography (internet) and video game consoles with violent games during that same time period.
suggests that they are migrating
:)
Or it could be some sort of complicated mating dance between rocks, before they rub together and eventually produce mountains in geological time...
Hey you know what? Fuck yourself.
I think you're the same asshole who goes around whining when people say "Micro$oft" and "Winblowz" too, aren't you? Well I have news for you - take your politically correct agenda and SHOVE IT UP YOUR ASS. People will express themselves however they damned well please, and no one gives a shit about your whining. MAFIAA has been used for YEARS on slashdot, and it's not your sniveling that is going to change it. Have a nice day. Dunbal.
I laugh at your feeble attempt at a troll.
Oh the whackos are good at piracy. My ex wife is a right wing Christian loony evangelical umm I ran out of adjectives, anyway, I remember her spending hundreds of dollars buying CD's loaded with Christian music - every single one of them a pirated copy.
But I guess if you're doing "god"'s work, it doesn't matter if you rip people off. Funny how the pastor drove a mercedes and the wife was always going around in gucci and luis vuitton stuff, though. Especially in this poor country.
On a side note, I was surprised to hear from someone today that the PATRIOT act has resulted in 13,000 arrests of terrorists.
Wow, I feel "safer" already, now that these "terrorists" are behind bars.
so you don't find summary execution to be a bit harsh?
did you even watch the "speeding ticket" dash-cam video?
This is shooting someone in the back with a taser for the "crime" of "walking away from a police officer".
except that, you need to give cops SOMETHING to control people.
a BRAIN?
Seriously, that's the choice in many situations - crazy meth'd-up homeless guy charges cop with knife...cop tases or cop shoots. Which do you prefer?
OK, how about "guy starts arguing about a speeding ticket". Now is this situation worth risking the person's life using the potentially lethal taser? How about this guy, who was rude and stole a microphone? Yes, let's risk his life too. Or how about these incidents?
Police need to be aware that every time they use a taser there is a small but REAL chance that they will kill the person they are shooting. Therefore they should be a lot more hesitant before using them than they are today. If as a doctor I perform a procedure on a patient without considering (and informing him of) the risks involved, I am liable for murder if the patient dies. The police should also be accountable, just like when draw their weapons - they need a VERY good reason to do that.
bloody geordies
When did quality cease to be a feature?
It certainly never was a feature in the software world. That was just "luck".
it's not just people in Britain that are experiencing the problem, but people in all parts of the UK.
OK I'll buy the England != UK bit, but Britain, ie "Great Britain" includes Scotland and Wales. That's why it's "The United Kingdom of Great Britain and Northern Ireland".
What about numerous UFO observations, Loch Ness etc? are you suggestion those should be regarded as proof of existence since there have been numerous observations and murky photographs? Science works by being skeptical, yes it can take decades for something to be acknowledged and that might be bad but taking every observation as proof would be worse.
Especially since the original perpetrator of the "Loch Ness Monster" hoax publicly admitted to it about 20 years ago in the UK, just before dying. Along with his admission was an apology, and what made him cough up the truth was seeing all the boats gathered with sonar equipment to finally, once and for all, put this myth to rest. He said he was ashamed that so many people had invested so much money for this.
But people love to believe bullshit, and even though this made the news in the UK at the time (I watched it), people still perpetrate the "Loch Ness Monster" BS. Don't even get me started on UFOs.
After you've left, all you've created is another determined enemy.
Not if you've killed them all!
German development of submarine warfare to counter their superior navy being the second
Germany rarely used their u-boats to attack the Royal Navy, and almost every time they did they got sunk for their trouble. The u-boats were commerce raiders, from the start.
Oh, and Godwin.
hackers can build their own, Linux-powered missile guidance systems,
Wow, I can't wait for the Microsoft lobby to push the government to make that "terrorist" OS illegal.
Certainly the light-saber duels would have had 1) a lot more people and 2) a lot more blood