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User: Rob+Simpson

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  1. Market forces? You're both right and wrong... on AIDS Drug Patent Revoked In US · · Score: 1

    Monopoly power allows sellers to raise prices above those they would obtain in perfectly competitive markets. In the jargon of economics, they are thus able to earn "rents," defined as the excess of the prices actually received by sellers above the minimum prices the sellers would have to be paid to sell into the market. Countries differ in the degree to which they try to whittle away at the rent earned on the supply side through the creation of market power on the buy (monopsony) side of the market. A single-payer system would be called a "pure monopsony." - Health Affairs, 22, no. 3 (2003): 89-105
  2. Here's what happened to your new antibiotic on AIDS Drug Patent Revoked In US · · Score: 1
  3. Re:I can feel the kindness on AIDS Drug Patent Revoked In US · · Score: 4, Insightful

    This is what publicly-funded research is supposed to be for.

  4. Coagulation wouldn't be a factor on Engineers Have a Terrorist Mindset? · · Score: 1

    While he probably used something more potent than warfarin, the anticoagulant effect of these drugs occur via inhibiting the synthesis of vitamin K dependent clotting factors. This would take days to have any effect on the ability of the blood to clot. Even a "lethal" dose could be cured with sufficient vitamin K. And while they do damage capillaries and increase their permeability, this effect also takes days and is minor without inhibition of clotting factors.

    He should've gotten together with one of those medicine terrorists. Actually, no, it's a good thing he didn't.

  5. Clarity of the punchline-like analysis? on Engineers Have a Terrorist Mindset? · · Score: 1

    " Among Lazy, Illiterate American Auto workers,
    that 40% of all sick time was taken on a Monday
    or a Friday". The class (mostly) was dumbstruck.


    I'd be dumbstruck too - aren't they shift workers? 9 to 5ers might not have heard of such a schedule, but it usually involves working four days for 10 hours each, with 4 days off, and including Saturday and Sunday. So I'd expect there to be a little less than 29% of sick time on a Monday or a Friday.

  6. Arguably, about half the population are chimeras on Teen Takes On Donor's Immune System · · Score: 1

    Also known as females:

    Why does X-inactivation result in chimeras, individuals with genetically distinct areas of their bodies? In female mammals one X chromosome in every cell is inactivated. The inactivation occurs early in development when the embryo consists of only a few cells. The inactivation is random - one X chromosome may be turned off in one cell and the other X chromosome inactivated in a neighboring cell. Once a chromosome is turned off it remains turned off in all descendent cells. With respect to their X chromosomes, female mammals are chimeras. A chimera is an organism composed of different genotypes. Some areas of their bodies have one X chromosome turned off and other areas have the other X chromosome inactivated. An example of X-linked chimeras that can be seen visually are female cats that are heterozygous at the orange coat color locus. Orange is a locus on the X chromosome. Females with one allele for orange color and one for non-orange (tortoise shell and calico cats) have blotches of orange and other colors all over their bodies. Each blotch of color is composed of cells descended from a single cell in the embryo at the time of X-inactivation.

  7. Probably not HIV, but many other diseases on Teen Takes On Donor's Immune System · · Score: 1

    HIV can infect other cells than just those of the immune system, for one thing.

    However, many diseases are caused by malfunctions of the immune system, including asthma, lupus, IBS, rheumatoid arthritis, and multiple sclerosis. Type I diabetics can't produce insulin because their pancreatic beta cells have been destroyed by such an autoimmune response. This could be huge.

  8. Re:exactly what I guessed. on Microsoft Insider Details Xbox 360 Red Ring Problems · · Score: 1

    Yeah, I remember seeing that case. I would have actually considered buying one - but then I thought about how much of a pain upgrading it would be.

    Btw, my case is an Antec Solo, and getting low temperatures with virtually no noise is very easy with this one.

  9. Re:exactly what I guessed. on Microsoft Insider Details Xbox 360 Red Ring Problems · · Score: 1

    Yes, every bit of cooling helps, but conducting heat to the outside requires a temperature gradient. (Second law of thermodynamics.) "Pushing as much energy as you possibly can into and through them" means keeping the inside of your case as hot as possible. This is not a good idea.

    The metal of my case is is cool to the touch. It is probably a few degrees above room temperature, but less than 37 degrees - so when I touch it, heat is conducted away from my hand. According to the sensors, it is 29 degrees inside the case.

  10. Re:Uh? on Cell Phone Sommeliers on the Way? · · Score: 1

    I hope they paid for your cellphone plan, too, or that's a kinda crappy gift. Anyways, most phones have some sort of privacy mode where it won't ring but will show you if someone's called (if you're interested). Or you could just leave it off and only turn it on if you need to make a call.

  11. Re:"not designed with the American consumer in min on Hacking the XO Laptop · · Score: 1

    Well, being unable to use WPA out of the box - and still being unable to connect to a hidden ssid - doesn't count as "polished" to me.

    The hardware is beautiful, but the software needs some work.

  12. Re:exactly what I guessed. on Microsoft Insider Details Xbox 360 Red Ring Problems · · Score: 2, Informative

    I believe the GP said "on a display unit, and if it's too warm", not "on the exhaust vent". If your cooling system if doing a good job, the side or top of your case isn't going to be hot, is it?

  13. Re:A 6 pound laptop? Really? on Apple Announces MacBook Air · · Score: 1

    D'oh, that'll teach me to read... though looking at the MacBook Pro, which the previous poster changed the subject to, comes with its own video memory, while the HP is only upgradeable to an nvidia 8400M GS - which still uses shared memory. While getting dedicated video memory comes with a price jump, it does look like there are plenty of laptops that are better deals, like this ASUS which is $1000 cheaper than a MacBook with the same or similar components and 1 GB less RAM.

    I can seem them justifying charging extra for OS X, and maybe the chassis is of higher build quality... but $700 to upgrade by 2 GB of RAM is crazy...

  14. Re:Slashdot has error in article, reports as news on 10-year-old Microsoft Ticket Resurfaces? · · Score: 1

    The Microsoft employee entered "1/8/08" to schedule the follow-up call; it would've come up automatically on that date.

  15. A 6 pound laptop? Really? on Apple Announces MacBook Air · · Score: 1

    Sure, it's cheap, but not exactly an ultraportable. A better comparison would be to a Thinkpad X-series. Or maybe a Toshiba Portege or a Fujitsu Lifebook. Heck, the Asus eee is closer to this than that HP. (And unlike the Apple, it has three USB ports, a swappable battery, and an ethernet port.)

  16. Antibiotics. Also, MHC. on US FDA Deems Cloned Animals Edible · · Score: 2, Insightful

    So, organisms will just take the traits from that make cells of the anti-biotic taking organism resistant to the anti-biotic. Problem solved.

    This doesn't happen... the reason animal cells aren't killed by antibiotics is because of fundamental differences between eukaryotes and prokaryotes. The ribosomes, used to make proteins are very different. Also, other antibiotics attack DNA gyrase and the formation of cell walls, which animals don't have.

    Instead, bacteria can either mutate or readily swap/steal genes from other bacteria* to make proteins to destroy antibiotics (penicillinase), enable them to pump antibiotics out of themselves, or change the site of bacterial action just enough to make the antibiotic no longer work.

    To get back on topic, one major problem with a "supercow" is that all the clones would have the same MHC. Genetic diversity at these genes ensures that at least some individuals in a population will be able to present an effective immune response to any pathogen.

    *Specifically, pathogenic ones can obtain them from harmless bacteria that have evolved resistance through too much exposure to antibiotics.

  17. (-1, Misleading) on Solar Cycle 24 Has Started · · Score: 1

    Barely worth even quoting wikipedia for, but mods are on crack, so...

    "Since sunspots are dark it might be expected that more sunspots lead to less solar radiation and a decreased solar constant. However, the surrounding areas are brighter and the overall effect is that more sunspots means a brighter sun."

  18. Learn to read on UK Moves to Outlaw 'Hacker Tools' · · Score: 1

    "abused by hackers"

    Abused. Presumably, it can also be used by hackers in legal ways.

  19. So where did you get 30% from? on Cocaine Vaccine In the Works · · Score: 1

    Oh, right, you made it up. With millions of people on a drug, even a chance of 0.01% will show up hundreds of times.

  20. Wrong on Cocaine Vaccine In the Works · · Score: 1

    30% experienced psychotic episodes?! Are you high? It can cause cause strange dreams in maybe ten percent of people, but nausea (the most common side effect) is the only one close to that percentage.

    The only psychotic episodes with varenicline that I'm aware of have been in people who had them already.

  21. Data on Cocaine Vaccine In the Works · · Score: 1

    For weeks 9 through 12, the 4-week continuous abstinence rates were 44.0% for varenicline vs 17.7% for placebo (odds ratio [OR], 3.85; 95% confidence interval [CI], 2.70-5.50; P less than .001) and vs 29.5% for bupropion SR (OR, 1.93; 95% CI, 1.40-2.68; P less than .001). Bupropion SR was also significantly more efficacious than placebo (OR, 2.00; 95% CI, 1.38-2.89; P less than .001). For weeks 9 through 52, the continuous abstinence rates were 21.9% for varenicline vs 8.4% for placebo (OR, 3.09; 95% CI, 1.95-4.91; P less than .001) and vs 16.1% for bupropion SR (OR, 1.46; 95% CI, 0.99-2.17; P = .057). Varenicline reduced craving and withdrawal and, for those who smoked while receiving study drug, smoking satisfaction. No sex differences in efficacy for varenicline were observed. Varenicline was safe and generally well tolerated, with study drug discontinuation rates similar to those for placebo. The most common adverse events for participants receiving active-drug treatment were nausea (98 participants receiving varenicline [28.1%]) and insomnia (72 receiving bupropion SR [21.9%]).

    Varenicline, an {alpha}4beta2 Nicotinic Acetylcholine Receptor Partial Agonist, vs Sustained-Release Bupropion and Placebo for Smoking Cessation
  22. Well, I wasn't exactly the most rabid SUSE fan... on Microsoft Paid Novell $356 Million in '07 · · Score: 1

    ...but I switched to Linux Mint.

  23. Re:What can you do with it? on Just What is this ASUS Eee Thing Anyway? · · Score: 1

    A real keyboard is much nicer than a thumbboard (though a bluetooth keyboard with a n810 might be okay), and the screen is bigger in size - but the resolution is identical (800×480) and (for surfing the web) I find tapping on links with the stylus to be easier than working the small trackpad on the eee.

  24. How is this insightful? on Linux And Unix Devices Popular On Amazon's 'Best of '07' List · · Score: 1

    Which mobile sold the most units? The one running this.

  25. Thank you on Wii Can't Replace Actual Exercise · · Score: 1

    3000 Calories an hour (60/0.02) seemed a bit high.