Answers: Stem cells. You say "it doesn't regenerate" but you're wrong. Babies regenerate it. We just need to get the same process going in adults.
elastin.. when babies make it it's loose, as they grow it tightens, like a trampoline.. and then sags as the trampoline gets abused by the kids who wont stay off your damn lawn.. anyway,, putting in new elastin wont fix the trampoline, because it wont get stretched, you'll just have a trampoline that is saggy, with room to expand.
Here are the spots that seem like monsters to overcome..
1. elastin.. It's not alive, it doesnt regenerate. and even if replaced in a full sized organism, it would already be "loose" because it tightens as we grow, and eventually breaks down.. How do you replace this substance throughout the body? (I'm hoping this covers a bunch of the other materials of the same type)
2. degradation of cell function.. as mutations occur in cells, the functional protiens become non-functional.. while these arent cancerous, they are problematic as they're just hobos in the body. to stop this would require freakloads of genetic therapy, rather than the smaller amount needed to repair cancer.
3. Overcoming telomerase,, so does it get nuked by your gene therapy, or are the stem cells engineered to full length only..
4. How do you keep the protein digesting enzymes needed for removing garbage from inside cells from eating barr bodies and other useful proteins that would normally inhabit and possibly pollute a cell.
5. How do you prevent damage to someone who has 2 copies of a gene that are both useful (the two having a broader functional range than any known single gene) from getting your genericized version at both? wiping out the advantage.
6. How do you keep the memories from fading to nothing?
While everyone seems to be an ergonomic freak.. I have a different perspective..
My co-workers call it circus coloring..
I set all of my common commands to yellow.... cout + = -.size() >>
I set my comparisons to green == > =>
This shows vector >vector >int>> myvar as being bad code..
I set my common variables to purple.. so result, input, size, index, total, min, max
I dont use sum as purple because total is my default, sum isnt..
Any common misspellings like retrun are colored inverse yellow.. so I dont even think about it when I fat finger it
comma and period.. green and cyan.. a typo should be obvious from color.. the = vs == saves me a whole lot of grief.
If something is White in my code.. it is because it's not in my standard flow.. so It sticks out as well.
Astronomers are people who know far more than how to use a telescope.. However the telescope is a painfully vital piece of what they do. The same with computer Science.. while using a computer and programming are peices of what is involved, it is far from the whole picture..
A computer Scientist can devise methods of representing data that take less space than normal.. or propose the least redundant way of gathering information. Or find the solution to puzzles such as lights out. Basically a Solid Cosc Grad should be able to solve riddles, handle math at a level that makes most people shake their heads in general disbelief.. having an Idea how long half a million seconds is in human terms. or a billion seconds. Being able to prove that a problem is or isnt solvable..
So this leaves careers that have some dependencies in logic.. such as train routing, UPS truck routing.. telephone circuit design. General supply logistics.. Unfortunately, these jobs are already filled by cosc people, and they are programming that stuff too.. because a good programmer is a lazy programmer.. and they dont want to duplicate their own work..
so other possibilities include.. QA programming.. you just try and break code.. sure there is some programming involved, but you go home at five..
Re:RAID5 is stupid, RAID 10 or no RAID
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What NAS To Buy?
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ok, on raid 5 any 2 broken drives will cause failure.. but you are running 3x speed.. with raid 10.. 50% of 2 drive breakdown will cause failure.. and your down to 2x speed.. so its a tradeoff
2. I want selection in file systems, not just a bunch of GP choices.. I want special purpose choices for those spots where it is really needed.
3. yes, I like reiser4 and hope it goes on.
4. I kind of disagree about the concept of reading the small files as a big block only being for tape drives... I think that having a system auto-cache the small files in a directory once it's opened, having all of them read in one fell swoop is a do-able proposition.. with some limits of course.. but in most cases it's a slam dunk.
It wasnt healthcare.. it was massive doses of DDT kill the mosquitos for a few years and malaria disappears.. repopulate the area with bugs that don't carry malaria and it goes away..
Mammals are a huge reservoir of the disease, all the medicine in the world wont clear the disease from an area..
aarrgggg.... intergenic regions of bacteria are reasonably important.. regulation of the production of proteins is a really important process. being able to add an artificial control mechanism to genes that are guaranteed not to exist in nature is a powerful tool.. While temperature sensitive promoters are impressive, they still have some problems. But having a fully artificial promoter sequence should allow for some really impressive experiments once a bit more technology is added to the system. Plus it can make some really big changes in RNA folding..
Ok, I understand the reasons for moving from Ext2 to ext3.. but then all this effort to support a bunch of Me-too's journaled file systems each with some marginal improvements over the rest of a crowded field. It seems like a bunch of work for a minor payoff....
The problem that I see that isnt addresses in native linux file systems is small files. try and copy a folder with 50k files each sized from 1k to 10 k each 100 meg total.. so copying a tar file with this much information is an operation that can occur in 4 seconds or less. BUT as small files it is not even close to as fast.. the copy time can run 40 minutes... the file system isnt right for this kind of work.
Anyway I would like to see a much wider array of file systems out there.. especially a file system that is designed to handle small files in a manner which is near the operation bandwidth of a conventional hard drive. Now I'm aware that this isnt a concern for a bunch of people.. but it really should be.. small files are what cause really nasty bottlenecks. look at windows it loads information off the hard drive way too slow during bootup
Nope, not everything gets modded up, just most things..
Of course newspapers leave headlines that leave me as a mass murder like --Storm kills 300 in the Philippines -- --Storm leaves orphans homeless-- --Storm invades your privacy-- --Storm discontinued by geo-- --Storm discontinued by Coca Cola--
I had a compiler class a few years back, we wrote a java compiler that produced MIPS code..
sure, we skimped on the java implementation.. but it was able to handle simple functions like factorial, and sorting algorithm, Objects.. I didnt manage to get inheritance to work, but that's my goof.
Try getting foxit to launch a web browser after you've removed adobe...
And of course the well meaning friends will install the whole bloody pirated thing.
I have no clue as to why this program takes upwards of a minute to read a simple pdf file that is mostly text. It really boggles my mind as to what the computer could be doing with that time/cycles.. Where as foxit can load the same pdf in a blink of an eye.. but microsoft loves to revert the extentions to adobe, unless I march through a convoluted maze to revert it back. never let your well-meaning friend install adobe on your box, it's a nightmare to remove.
The difference is there.. The Zebra stripes don't help the top 2 or the bottom 2, only the middle two. so the questioned only needed to count to three in either direction to get their bearings. do this with a 50 line document, and I'm betting that the difference will magnify.. increase the distance left-right by printing landscape, and watch it zebra strut it's stuff.
ok, I'll agree ext4 blows..
XFS and Jfs are dogs in the small file arena. sure they both address it, but neither one does it well. nor do they have undelete, which is pretty nice. and one second file timing is a bit on the loose side, especially if your running a batch that checks that sort of thing. And none of these are tuned for a SSD at all.
So yes we need upgrades, big time, ext4 isnt it..
We invent representations for all sorts of things.. even without math, if you take a basket filled with apples, take an apple out, and place it back in, repeat ad nauseum, the basket will never empty..
Anyway, we built the representation of natural numbers. Plus, minus, and multiplication are invented transforms on natural numbers that were invented. as is the concept of exponentiation. These representations are useful.. but often have shortcomings.. naturals cant represent all decimal values.. fixed length decimals cant represent irrationals.
Anyway we invent all sorts of representations, from cartesian coordinates to Hilbert space.. but the relations of the various transforms are discovered... That the hypotenuse of a right triangle squared is equal to the sum of the sides squared is discovered... That 360 degrees are in a circle is invented.. The concept of a right triangle is invented. But the trig that transforms angles to sin/cos is discovered..
Anyway if a representation is wrong, then we can create a new representation, and start discovery from scratch.. IE roman numerals for modern math, horrible for exponents, fantastic for adding numbers together.... however bad discoveries point to a bad model, or to poor logic.
office flogging for not adding a cover sheet to the tps report.. bamboo shoots under the fingernails for not using the corporate greeting.. and dont even ask what they do to people who aren't wearing enough flair.
its a matter of time.. cores on cpu should explode soon. The kicker is that per transistor it makes sense to have simpler cores.. so each core isnt as fast per clock cycle.. like a pentium vs a 486, 3x the transistors for a 1.5 clock cycle efficency boost.
so max crunching will occur on a whole beastload of weak processors.. if we can use them in a respectable fasion.
oh, most software doesnt run well as a single thread, otherwise it wouldnt take so bloody long for the address bar to keep up with my typing when I get stuck at some god forsaken web page that I really want to get off my screen because I mistyped microsoft or google. watching the letters slowly come up one at a time is horrible on a core2duo when IE is the only app open. apps need some massive re-engineering.
Evolution theory is based on the hypothesis that we have common ancestry, and incremental changes cause branching.. so there isnt cut-and paste at the end points. and there should be evidence consistent with gradual change.
So we have common ancestry.. we have a DNA system which pervades all of life (viruses and prions not considered life in modern texts).
There is a conserved DNA- to -Protein language, with few slight exceptions. solid common ancestry.
Conserved ribosomes are closest in organisms that appear to be related. Synteny(sameness on gene order) is highest in related organisms.
so we have incremental changes nailed
Now we haven't found cut and paste yet that will cause some consternation in scientists.. so if we find a feathered crocodile, a mammal with octopus style eyes , a bat with a four chambered lung, or a bird with bug eyes then we have an example of cut-paste.. the platypus is a case of offshooting before mammals lost most reptile traits.. and its a neat case, but isnt a cut-paste example..
Storm
p.s. the clock article is neat but the non-coding areas of MT DNA are under evolutionary pressure, so the math is getting bad inputs.
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elastin.. when babies make it it's loose, as they grow it tightens, like a trampoline.. and then sags as the trampoline gets abused by the kids who wont stay off your damn lawn.. anyway,, putting in new elastin wont fix the trampoline, because it wont get stretched, you'll just have a trampoline that is saggy, with room to expand.
1. elastin.. It's not alive, it doesnt regenerate. and even if replaced in a full sized organism, it would already be "loose" because it tightens as we grow, and eventually breaks down.. How do you replace this substance throughout the body? (I'm hoping this covers a bunch of the other materials of the same type)
2. degradation of cell function.. as mutations occur in cells, the functional protiens become non-functional.. while these arent cancerous, they are problematic as they're just hobos in the body. to stop this would require freakloads of genetic therapy, rather than the smaller amount needed to repair cancer.
3. Overcoming telomerase,, so does it get nuked by your gene therapy, or are the stem cells engineered to full length only..
4. How do you keep the protein digesting enzymes needed for removing garbage from inside cells from eating barr bodies and other useful proteins that would normally inhabit and possibly pollute a cell.
5. How do you prevent damage to someone who has 2 copies of a gene that are both useful (the two having a broader functional range than any known single gene) from getting your genericized version at both? wiping out the advantage.
6. How do you keep the memories from fading to nothing?
Thanks,
Storm
Storm
it's a macbook.. so the keyboard isnt coming off.. not even like a compaq laptop..
So anyway, damp rag with isopropyl alchohol will kill the bugs.. really consider it once a week, as keyboards are nasty..
Storm.. Molecular Viologist.. um Biolifist... I have a degree in skience
My co-workers call it circus coloring..
I set all of my common commands to yellow.... cout + = - .size() >>
I set my comparisons to green == > =>
This shows vector >vector >int>> myvar as being bad code..
I set my common variables to purple.. so result, input, size, index, total, min, max
I dont use sum as purple because total is my default, sum isnt..
Any common misspellings like retrun are colored inverse yellow.. so I dont even think about it when I fat finger it
comma and period.. green and cyan.. a typo should be obvious from color.. the = vs == saves me a whole lot of grief. If something is White in my code.. it is because it's not in my standard flow.. so It sticks out as well.
A computer Scientist can devise methods of representing data that take less space than normal.. or propose the least redundant way of gathering information. Or find the solution to puzzles such as lights out. Basically a Solid Cosc Grad should be able to solve riddles, handle math at a level that makes most people shake their heads in general disbelief.. having an Idea how long half a million seconds is in human terms. or a billion seconds. Being able to prove that a problem is or isnt solvable..
So this leaves careers that have some dependencies in logic.. such as train routing, UPS truck routing.. telephone circuit design. General supply logistics.. Unfortunately, these jobs are already filled by cosc people, and they are programming that stuff too.. because a good programmer is a lazy programmer.. and they dont want to duplicate their own work..
so other possibilities include.. QA programming.. you just try and break code.. sure there is some programming involved, but you go home at five..
ok, on raid 5 any 2 broken drives will cause failure.. but you are running 3x speed.. with raid 10.. 50% of 2 drive breakdown will cause failure.. and your down to 2x speed.. so its a tradeoff
Storm
2. I want selection in file systems, not just a bunch of GP choices.. I want special purpose choices for those spots where it is really needed.
3. yes, I like reiser4 and hope it goes on.
4. I kind of disagree about the concept of reading the small files as a big block only being for tape drives... I think that having a system auto-cache the small files in a directory once it's opened, having all of them read in one fell swoop is a do-able proposition.. with some limits of course.. but in most cases it's a slam dunk.
Mammals are a huge reservoir of the disease, all the medicine in the world wont clear the disease from an area..
Storm
Storm
Ok, I understand the reasons for moving from Ext2 to ext3.. but then all this effort to support a bunch of Me-too's journaled file systems each with some marginal improvements over the rest of a crowded field. It seems like a bunch of work for a minor payoff.... The problem that I see that isnt addresses in native linux file systems is small files. try and copy a folder with 50k files each sized from 1k to 10 k each 100 meg total.. so copying a tar file with this much information is an operation that can occur in 4 seconds or less. BUT as small files it is not even close to as fast.. the copy time can run 40 minutes... the file system isnt right for this kind of work. Anyway I would like to see a much wider array of file systems out there.. especially a file system that is designed to handle small files in a manner which is near the operation bandwidth of a conventional hard drive. Now I'm aware that this isnt a concern for a bunch of people.. but it really should be.. small files are what cause really nasty bottlenecks. look at windows it loads information off the hard drive way too slow during bootup
Of course newspapers leave headlines that leave me as a mass murder like --Storm kills 300 in the Philippines -- --Storm leaves orphans homeless-- --Storm invades your privacy-- --Storm discontinued by geo-- --Storm discontinued by Coca Cola--
Storm
the far side, keeps the radio garbage from earth in check.. but gets the same amount of light.. But the idea is pretty awesome.
sure, we skimped on the java implementation.. but it was able to handle simple functions like factorial, and sorting algorithm, Objects.. I didnt manage to get inheritance to work, but that's my goof.
Storm
Try getting foxit to launch a web browser after you've removed adobe... And of course the well meaning friends will install the whole bloody pirated thing.
Storm
The difference is there.. The Zebra stripes don't help the top 2 or the bottom 2, only the middle two. so the questioned only needed to count to three in either direction to get their bearings. do this with a 50 line document, and I'm betting that the difference will magnify.. increase the distance left-right by printing landscape, and watch it zebra strut it's stuff.
ok, I'll agree ext4 blows.. XFS and Jfs are dogs in the small file arena. sure they both address it, but neither one does it well. nor do they have undelete, which is pretty nice. and one second file timing is a bit on the loose side, especially if your running a batch that checks that sort of thing. And none of these are tuned for a SSD at all. So yes we need upgrades, big time, ext4 isnt it..
wait for infinite loop to finish..
repeat as needed.
Storm
dammit,, they released my facebook to the internets...
Anyway, we built the representation of natural numbers. Plus, minus, and multiplication are invented transforms on natural numbers that were invented. as is the concept of exponentiation. These representations are useful.. but often have shortcomings.. naturals cant represent all decimal values.. fixed length decimals cant represent irrationals.
Anyway we invent all sorts of representations, from cartesian coordinates to Hilbert space.. but the relations of the various transforms are discovered... That the hypotenuse of a right triangle squared is equal to the sum of the sides squared is discovered... That 360 degrees are in a circle is invented.. The concept of a right triangle is invented. But the trig that transforms angles to sin/cos is discovered.. Anyway if a representation is wrong, then we can create a new representation, and start discovery from scratch.. IE roman numerals for modern math, horrible for exponents, fantastic for adding numbers together.... however bad discoveries point to a bad model, or to poor logic.
Storm
office flogging for not adding a cover sheet to the tps report.. bamboo shoots under the fingernails for not using the corporate greeting.. and dont even ask what they do to people who aren't wearing enough flair.
so max crunching will occur on a whole beastload of weak processors.. if we can use them in a respectable fasion.
oh, most software doesnt run well as a single thread, otherwise it wouldnt take so bloody long for the address bar to keep up with my typing when I get stuck at some god forsaken web page that I really want to get off my screen because I mistyped microsoft or google. watching the letters slowly come up one at a time is horrible on a core2duo when IE is the only app open. apps need some massive re-engineering.
That shows the how, but not really the full on why. What is the advantage? or is it simply a loss of function due to prolonged exposure to citrus?
Evolution theory is based on the hypothesis that we have common ancestry, and incremental changes cause branching.. so there isnt cut-and paste at the end points. and there should be evidence consistent with gradual change.
So we have common ancestry.. we have a DNA system which pervades all of life (viruses and prions not considered life in modern texts).
There is a conserved DNA- to -Protein language, with few slight exceptions. solid common ancestry.
Conserved ribosomes are closest in organisms that appear to be related. Synteny(sameness on gene order) is highest in related organisms. so we have incremental changes nailed
Now we haven't found cut and paste yet that will cause some consternation in scientists.. so if we find a feathered crocodile, a mammal with octopus style eyes , a bat with a four chambered lung, or a bird with bug eyes then we have an example of cut-paste.. the platypus is a case of offshooting before mammals lost most reptile traits.. and its a neat case, but isnt a cut-paste example..
Storm
p.s. the clock article is neat but the non-coding areas of MT DNA are under evolutionary pressure, so the math is getting bad inputs.