There are beauties to a computer model. it can perturbed. Lets say that you model a carcinoma, that is undergoing a drug treatment that impairs its ability to build mitochondria.. The Cancer will mutate to switch to a glycolosis process for most of its energy. But to go glycolytic, it will need to grow more capillaries, so you could add in chemicals that prevent angiogenesis. Or you could starve the patient of glucose, providing a super low carb diet, to cause the cancer to die from lack of nutrients.
Basically an oncologist should be able to get a rough guess of how a series of treatments will work, and if a set of treatments is just going to make a more resilient cancer, then they can consider more viable options. Cancer is tricky, and some treatments arent effective at the same stages.
umm how to start.. The guts of the matter are that having more genetic information about someone is usually usefull. The more we discover the more we can determine the effacacy of different medications.. if someone is missing a receptor for morphine then it's just going to give them constipation.
The CNV variations wouldnt show that something is missing, but it might help with dosing requirements. If there are more copies of a blood clotting factor in a person who has just survived a mild stroke, then a closer guess can be made on how much coumadin (blood thinner) should be administered.
Since I'm having a half-baked what-if moment I'll paint the following scenario...
Google modifies a painfully stripped down OS, let go BSD based for fun..
The guts of the system are based on a new security model, where the
applications have no capability to write to anything other than the
directories it controls, and to files it already owns. The only way
to make a new file outside of controlled directories would be via the
"open window" Which could be requested by an application, but not controled by it.
The real guts would be that all applications would talk to a pretty paired down OS.
No linked libraries ever, no.dll,.o or.so files ever touch the OS from outside. No abilities to change system wide settings from an application. Applications that needed to access the parts of the system would need to be vetted by google and digitally signed.. for instance a yahoo chat client, it wouldnt be able to connect to the internet without being signed (the signing would infer different trusts depending on the signature.).
While the system seems like a pain for coders to put applications on, It's what I'd like to have on my parents PC, an OS that can get things done, without getting a whole bunch of junkware installed, And even if they install 17 different photo-editing suites, then remove the last three, it wouldn't cause the priner to flake out about a sd card reader not found.
Right now the system is plain up goofy, regardless of OS. Mac apps tend to play better, but mostly because you dont have hardware companies writing junk applications for Mac's They just omit it, really it's a blessing. Of course I'm bitter since my Belkin software just jumped all over my Netgear Hardware Settings last night.. Catharsis on slashdot, because someone else should feel my bitter frustration.
I could care less, by a good 88 percent.. but I'm really not that uncaring..
If I said "I couldn't care less" It would mena that I was totally unaware of the situation, or completely incapacitated, of which neither is currently true.
Oh there is a funky problem... letters that look identical in different languages. could allow for spoofing.. so if the link had a dual-language character-set it would need to multicolor the thing so that it would look pretty odd.. so that microsoft.com and mîcrosoft.com would be clearly distinguishable (reverse the î character so that it's white on black)
but I still it's workable.
Set up a private latin name prefix for the non-latin names
i.e. NONLATINPREFIX and then a UUEncode of the non-latin name.. IE
(arabic word for horse in arabic script)=AER5ER8EDG
so you would have NONLATINPREFIX-AER5ER8EDG.com as a domain name, that would resolve correctly if someone typed in (arabic word for horse in arabic script)..
1. This allows for simple web-extention to serve non-latin countries
2. Doesnt require any change to the DNS system. (other than some name policy changes)
3. Allows links to be imbedded in normalweb-pages so that they can be cut and pasted by anyone with latin functionality. So a Japanese person could cut and paste the link to some arabic site that they dont have the font for.
4. While this is a kludge it has some major advantages over rebuilding the DNS system.
Sure the kid got some attention, and may have been a bit of a jerk in the process. I could care less. The problem lies with the fact that with four officers around, and a non-violent suspect of a non-violent offense decided that tazering the guy would be the appropriate measure. One officer could have easily placed the "suspect" under arrest with simple handcuffs without a wrestling match, as the "suspect" was simply going limp. But in their wisdom they decided that getting him to comply via shock was the correct procedure.
Four Officers... one kid come on.. They could have talked this kid into the handcuffs, while he was a jerk he wasnt exactly a threat.
Sorry the police are here to serve and protect, their actions are the actions of thugs who enjoy weilding power. So while I might not be deeply sorry for the kid, I am deeply ashamed of the actions of the law enforcement officials.
You need to get a 4th and 5th person. The hiring can be a mess, I've made mistakes and lived with others mistakes.
First make sure that they have some skills, a specific skill set is sometimes overdone.
Some Skills/Experince that you want to be looking for.
1. Shell Scripting, can your person make changes to dozens of machines at one time when you have a crunch.
2. Obscene famialiarity with the OS.. A headphone jockey can walk a user through hell and back, if they know exactly what is popping up and why you can save a huge amount of time. If theyre good they can walk someone through a network stack rebuild with their eyes shut.
3. Wicked soft skills. With the right phrasing "Your machine is going to be a bit odd for a couple weeks" becomes "Just click the new shortcut, until we can get a nice block of time that more convenient for you." And you have suddenly moved from frustration to elation.
4. Good Work attitude, If the person is a pain in the rear to work with it will be a disaster.. Screening for the bad-neurotic is a hard trick. Probe the three innapropriate topics of conversation, Unix-Windows-Mac can be used for religion, but if the applicant keeps rambling in any direction, point them at the door.
5. Brainiac Troubleshooting.. If the person can manage to systematically reduce a problem to smaller problems then you have someone who can tackle some of the larger issues of a site.
6. Experience.. There are quite a few technicians that have already supported these issues If you manage to grab a Technician that has worked in both the homogenous and the heterogenous environments, you can find some pearls of wisdom on handling the issues with each.
Take some real time to screen the applicants.. sure 90% are going to be junk and of that you need to spend a bit of time making sure that your not going to go insane working with them. Check some references dig a bit.
Yea, Its an American thing..
Back in the 20-30's DeBeers made a huge marketing push, where diamonds would be a big part of movies, and had stars wearing their products. DeBeers made the Diamond the DeFacto trinket to prove love. So it ran crazy in our culture. So diamonds which were cheaper than colored stones became more expensive. Now if your not wearing a diamond in a wedding ring society really makes some nasty assumptions.
However I dont even care for the artificial diamond. The lengths that people have gone for diamonds is abhorrent, wearing a fake diamond still appears condons the actions of the diamond industry.
Personally Id go synthetic emerald, I like the way they look
So Really if you want to go and smoke pot daily, you need to get citizenship, then have "traumatic brain injury" so that you are mentally handicapped, then you can smoke pot all day. As long as you share with your sitter. So sure it's the best of both worlds, lots of pot smoking time, and low taxes.
Really though, even faking mentally challenged would be a total drain on my life.
Folding is what's know as a rediculously parallel problem. That is, it can be broken up in to small subproblems that can be distributed among many processors with a minimal amount of communication among processors. It also benefits from not requiring a lot of branching (if/switch statements and such), which GPUs generally do not handle well.
Folding is a beast, and it isnt "rediculously parallel" The protien is broken into bounding boxes, and the amount of communications is really high. Even with gigabit lines, a fast switch breaking, and a large linear molecule. Trying to get performance boosts with more than 40 processors was a bear and we eventually scaled back to less processors to make better use of a cluser.
The Gromacs Code on an ATI card takes advantage of super low latency, and bandwidth.. It is a good case of taking a reasonably serial process and moving it to a parallel solution.
I would argue that a system that had a massivly parallel architecture could run rings arouns a current machine for operating system tasks. However the process of developing the code would require a army of top end coders to get something reasonably acceptable to the public at large. The current branching of a current microprocessor is a bit uglier for a gpu. However there are some very neat COSC/MATH tricks to make the IF disappear, If this were to be done smoothly you could have a faster IF than the currentIF. So getting a massivly parallel os any time soon is probably like hoping that BeOS will rise from the grave and take it's rightfull market share.:)
Depends on what your willing to call an assembler..
For the most part molecular biology is able to make some pretty small stuff.
So with some enzymes glucose and UTP can be used to polymerize into glycogen chains, the mix of branching enzymes can change the structure. Glucose could also polymerize into cellulose with alternate enzymes. These are reasonably workable in a vat.. whereas with Genetic Tampering you can manage to make a goat that has spider silk protein in her milk. (skip that goat cheese pizza), but then youve crossed that line of being "out of the vat". So quite a bit of nano-tech is available as long as you think outside the vat
Even in the vat there is a ton of stuff from a chemical, point of view
Dell is a bit funky.. I've dealt with them at two levels, From a Corporate Customer point of view, they rock.. plain and simple. They give you a phone number that picks up, you talk to someone who speaks english, and has some clue about whats going on. You tell them what peice is broken, what the service tag is (short tag numbers too), and they send you a new one, express. No asking if it's plugged in, no re-install windows, nothing. From a guy calling dell about a relatives box, it was a frickin nightmare, They are all about getting you off the phone, it's a mess, the wait times are long, the operators frustrated, and rushed. Their only goal is to get you to do something and call back.
HP is a bit less bend over backwards for corporate customers, but their hardware was pretty robust. However their software is written by drunken monkeys with bad attitudes. As long as you could use general microsoft stuff hp was great, if you had to use HP drivers for an officejet multi-function it was horrible. Add in a switchbox that would swap the parallel port and blue-screens were bound to occur. And their was nothing legitamate that HP's tech support could offer for advice.
or a 70 MPH trip this adjusts to 2.25 Million DVD's
or 225,000 (100 disk spindles) Each Spindle Weighs 4Lbs
I missed by an order of magnitude here... 2.25 M/100 = 22,500
so this moves it down to a 45 ton cargo .
Which isnt even close to the heaviest load on the road.
So while the new line isnt quite nothing compared to a truck, a truck can move more data 100 miles faster than the new link.
Yea a 747 with a 124 ton cargo capacity at 500 mph would fall just short of hitting it.. the capacity needed would require 126 tons of capacity. at 500mph.
Processors have become a commodity. You buy as much processor performance as you need or can afford. The Intel and AMD processors are all great right now...well all except the old Intel P4 and Celeron stuff but that will be mostly gone in a few months anyway. Move along...there's no story here.
ok, I'll bite....
This is slashdot. We look at specs and drool. We crave machines with 64 gigs of ram, and a solid state hard drive in the petabyte range. If there is some way to make things blinky or shiny, someone is wondering how much longer their kids can put off braces. If someone comes out with a way to make IE 7 beta 4 load pages 3% faster, someone is going to be running tests all night long. It's news for nerds, stuff that matters. Go troll on digg or break.com and you'll have a point, but not here.
All in all I'm glad that Intel has decided to retake the lead in the price/performance war, AMD needs a new kick in the pants.
Xp has some monster issues.. I blue-screened yesterday when I plugged my usb key into a lab machine. the security settings were a bit wonky, and poof blue-screen.. sure it came back up, and I saved before trying it so nothing lost... but DANG.. On any reasonable box it should fly. on a Perfectly fine Box it should never pull that bs.
Multiple boxes in IE manage to have [ok] and [cancel] boxed dyslexified on the keyboard, you press right to go left, and left to go right. In internet checkers, you can switch peices in the middle of a double jump. in IE7 the zoom functionality gets really odd, and doesnt work consistently right. Scrolling up and down in som appications leaves goofy artifacts on the screen. And when copying a large amount of files, Windows just freaks out and does some absurd "preparing to copy" garbage that just wastes time compared to a straight up xcopy. Switching/ closing windows is a bloody nightmare when windows "thinks" that it is doing something important.
comparativly XP isnt too shabby but it's still a long way from being right. and perfectly... oh frickin please.
Higher organisms have genetic safeguards that are stopping cancer ALL THE TIME. Generally multiple systems in a cell need to fail before cancer can begin.
The first thing that needs to fail is the proofreading enzymes, so that a gene or two are damaged without being repaired.
Then the "self destruct" needs to fail to activate in a cell, The self destruct is almost always armed and ready to go, unless it gets knocked out by a "lucky" mutation.
Even if the self destruct fails, the cell sensing needs to fail in order to grow beyond a few cells. Then the telemorase halting needs to fail in order for the cancer to reach something larger than a mole.
The immune system is a last resort, and not a very good one in comparison.
Slashdot Mirror
Strange, that FP is actually ontopic.... AC's and their bigfoot cards.
Storm
Basically an oncologist should be able to get a rough guess of how a series of treatments will work, and if a set of treatments is just going to make a more resilient cancer, then they can consider more viable options. Cancer is tricky, and some treatments arent effective at the same stages.
Storm
The CNV variations wouldnt show that something is missing, but it might help with dosing requirements. If there are more copies of a blood clotting factor in a person who has just survived a mild stroke, then a closer guess can be made on how much coumadin (blood thinner) should be administered.
Storm
The real guts would be that all applications would talk to a pretty paired down OS. No linked libraries ever, no .dll, .o or .so files ever touch the OS from outside. No abilities to change system wide settings from an application. Applications that needed to access the parts of the system would need to be vetted by google and digitally signed.. for instance a yahoo chat client, it wouldnt be able to connect to the internet without being signed (the signing would infer different trusts depending on the signature.).
While the system seems like a pain for coders to put applications on, It's what I'd like to have on my parents PC, an OS that can get things done, without getting a whole bunch of junkware installed, And even if they install 17 different photo-editing suites, then remove the last three, it wouldn't cause the priner to flake out about a sd card reader not found.
Right now the system is plain up goofy, regardless of OS. Mac apps tend to play better, but mostly because you dont have hardware companies writing junk applications for Mac's They just omit it, really it's a blessing. Of course I'm bitter since my Belkin software just jumped all over my Netgear Hardware Settings last night.. Catharsis on slashdot, because someone else should feel my bitter frustration.
Storm
If I said "I couldn't care less" It would mena that I was totally unaware of the situation, or completely incapacitated, of which neither is currently true.
Storm
Storm
2. Doesnt require any change to the DNS system. (other than some name policy changes)
3. Allows links to be imbedded in normalweb-pages so that they can be cut and pasted by anyone with latin functionality. So a Japanese person could cut and paste the link to some arabic site that they dont have the font for.
4. While this is a kludge it has some major advantages over rebuilding the DNS system.
Storm
Four Officers... one kid come on.. They could have talked this kid into the handcuffs, while he was a jerk he wasnt exactly a threat.
Sorry the police are here to serve and protect, their actions are the actions of thugs who enjoy weilding power. So while I might not be deeply sorry for the kid, I am deeply ashamed of the actions of the law enforcement officials.
Storm
software engineering and compiler writing courses
Software QA
formal theory classes and proofs
Software Optimization
knowlege of big O notation, lock-race conditions, and algorithms Software Architect
Sometime MIS works here for buisness applications, but for math intensive work I'd still go COSC. Hybrid Degrees
Being able to make good code for group that has a tough time doing it on their own.
just my $.02
Storm
1. Shell Scripting, can your person make changes to dozens of machines at one time when you have a crunch.
2. Obscene famialiarity with the OS.. A headphone jockey can walk a user through hell and back, if they know exactly what is popping up and why you can save a huge amount of time. If theyre good they can walk someone through a network stack rebuild with their eyes shut.
3. Wicked soft skills. With the right phrasing "Your machine is going to be a bit odd for a couple weeks" becomes "Just click the new shortcut, until we can get a nice block of time that more convenient for you." And you have suddenly moved from frustration to elation.
4. Good Work attitude, If the person is a pain in the rear to work with it will be a disaster.. Screening for the bad-neurotic is a hard trick. Probe the three innapropriate topics of conversation, Unix-Windows-Mac can be used for religion, but if the applicant keeps rambling in any direction, point them at the door.
5. Brainiac Troubleshooting.. If the person can manage to systematically reduce a problem to smaller problems then you have someone who can tackle some of the larger issues of a site.
6. Experience.. There are quite a few technicians that have already supported these issues If you manage to grab a Technician that has worked in both the homogenous and the heterogenous environments, you can find some pearls of wisdom on handling the issues with each.
Take some real time to screen the applicants.. sure 90% are going to be junk and of that you need to spend a bit of time making sure that your not going to go insane working with them. Check some references dig a bit.
Storm
However I dont even care for the artificial diamond. The lengths that people have gone for diamonds is abhorrent, wearing a fake diamond still appears condons the actions of the diamond industry.
Personally Id go synthetic emerald, I like the way they look
Storm
Really though, even faking mentally challenged would be a total drain on my life.
Storm
The Gromacs Code on an ATI card takes advantage of super low latency, and bandwidth.. It is a good case of taking a reasonably serial process and moving it to a parallel solution.
I would argue that a system that had a massivly parallel architecture could run rings arouns a current machine for operating system tasks. However the process of developing the code would require a army of top end coders to get something reasonably acceptable to the public at large. The current branching of a current microprocessor is a bit uglier for a gpu. However there are some very neat COSC/MATH tricks to make the IF disappear, If this were to be done smoothly you could have a faster IF than the currentIF. So getting a massivly parallel os any time soon is probably like hoping that BeOS will rise from the grave and take it's rightfull market share. :)
Even in the vat there is a ton of stuff from a chemical, point of view
Storm
HP is a bit less bend over backwards for corporate customers, but their hardware was pretty robust. However their software is written by drunken monkeys with bad attitudes. As long as you could use general microsoft stuff hp was great, if you had to use HP drivers for an officejet multi-function it was horrible. Add in a switchbox that would swap the parallel port and blue-screens were bound to occur. And their was nothing legitamate that HP's tech support could offer for advice.
Storm
Smug, but not athiestic.
Storm
oops. Storm
So while the new line isnt quite nothing compared to a truck, a truck can move more data 100 miles faster than the new link.
Storm
Storm
The distance traversed is 100 miles, which would take 1.4 hours, at 70MPH.
There are 3600 seconds in an hour.
This means that per hour a line can move 1.58 million DVD's
for a 70 MPH trip this adjusts to 2.25 Million DVD's
or 225,000 (100 disk spindles) Each Spindle Weighs 4Lbs
leaving 900,000 lbs or 450 tons..
That would be a semi with 200 cars loaded on it....
Now How big of a truck are you drivin....?
Storm
Go figure., gotta love math
ok, I'll bite....
This is slashdot. We look at specs and drool. We crave machines with 64 gigs of ram, and a solid state hard drive in the petabyte range. If there is some way to make things blinky or shiny, someone is wondering how much longer their kids can put off braces. If someone comes out with a way to make IE 7 beta 4 load pages 3% faster, someone is going to be running tests all night long. It's news for nerds, stuff that matters. Go troll on digg or break.com and you'll have a point, but not here.
All in all I'm glad that Intel has decided to retake the lead in the price/performance war, AMD needs a new kick in the pants.
Storm
comparativly XP isnt too shabby but it's still a long way from being right. and perfectly... oh frickin please.
Storm
The first thing that needs to fail is the proofreading enzymes, so that a gene or two are damaged without being repaired.
Then the "self destruct" needs to fail to activate in a cell, The self destruct is almost always armed and ready to go, unless it gets knocked out by a "lucky" mutation.
Even if the self destruct fails, the cell sensing needs to fail in order to grow beyond a few cells. Then the telemorase halting needs to fail in order for the cancer to reach something larger than a mole.
The immune system is a last resort, and not a very good one in comparison.
Storm