Well let's see, a patient comes in with a complaint. The doctor forms a hypothesis as to what is causing the problem(s) based on the available data (presenting signs, symptoms, epidemiology, etc..). He/she then orders tests or medication to gather additional data to support or refute the hypothesis. Based on the data from the tests, he/she either forms a new/better hypothesis, or arrives at a probable diagnosis.
Yeah -- I guess you're right. That doesn't sound very scientific-methody at all~.
I for one haven't bought a new CD (or asked for one) since the whole Sony rootkit thing came out. I never used to be a huge purchaser, but maybe around 1-2 dozen a year. But now I seriously don't have time to keep track of which CD's are going to screw up my computer and which ones don't. I don't P2P either -- meh, I just don't care enough. There is more than enough music in my music library to keep me happy that I don't need the latest and greatest release.
Nerve fibers in the peripheral nervous system (PNS - formed by cranial and spinal nerves) have the potential for regrowing. How successful they are at regrowing depends on the type of injury. Apparently the myelin sheaths formed by Schwann cells in the PNS (which, among other things, speed up the nerve signal conduction velocity and decrease metabolic demands on the cell for signalling) can also help the nerve regenerate axons in the case of trauma. If the trauma is a crushing one, then the nerve cell body may have more of a chance of regenerating through the existing myelin sheath infrastructure. If the trauma is a severing variety, then the cell body will send out cellular processes to try to reconnect with its target. This reconnection may or may not be successful. However, it is possible for motor cells that signal to one muscle to re-enervate another muscle (e.g. jaw winking where jaw nerve muscles re-enervate the eye after injury).
Injury to the central nervous system (CNS - spinal cord and brain) is a much different story. Here, the nerves are precluded from reconnecting with their targets to due scar tissue laid down by normally supportive cells (astrocytes). Other supportive cells (oligodendrocytes and microglia cells) may also release inhibitory factors thus preventing CNS regeneration.
we are going to find out that the "garbage" DNA is used for quaternary configuration or something else that we know nothing about. If someone were smart, they would be looking very heavily at that "garbage".
Not sure if you know about this, but you may want to look into epigenetics. Basically, it involves mechanisms that affect DNA expression without altering the underlying DNA sequence. Epigenetic mechanisms have been identified in such things as hereditary nonpolyposis colorectal cancer (microsatellite instability due to DNA methylation changes) and I believe some imprinting diseases such as beckwith-wiedemann or angelman syndrome.
If you are interested in reading more, you may want to look at the following articles:
Epigenetics and human disease, Jiang YH, Bressler J, Beaudet AL. [PMID 15485357]
Epigenetic reprogramming and imprinting in origins of disease, Tang WY, Ho SM. [PMID 17638084 ]
The oxygen in reperfusion injuries causes damage via its role in production of reactive oxygen species.
An older reference:
Considerable attention is now being devoted to the mechanism
responsible for the oxygen paradox. A leading contender is the
production of oxygen-derived free radicals, such as the superoxide
anion (O), the hydroxyl radical ( * OH), and H202, which
occurs as a consequence of the reintroduction of molecular oxygen
into previously ischemic tissue during reperfusion.[1]
Or this:
Cyclooxygenase catalyzes the addition of two molecules of O2 to an unsaturated fatty acid, like arachidonic acid, and produces prostaglandin PGG, which is rapidly peroxidized to PGH with concomitant release of O2[2]
The morphological progression of injury during reperfusion [10, 11 and 12] led to the hypothesis [43] that accelerated structural damage during reperfusion is a consequence of excessive generation of oxygen radicals followed by lipid peroxidation.
[1] Myocardial reperfusion: a double-edged sword?: PMID 4056048
[2] Brain ischemia and reperfusion: molecular mechanisms of neuronal injury: PMID 11054482
Desktop search is priceless to me. I am in medical school and we have 99.9% of our lectures in PPT format. I take notes with openoffice. Being able to quickly search locally lets me easily find material from months ago to refresh my memory on it and also to integrate old information with new information.
That being said, I used google desktop for several months but then I started having problems with it updating its index (removing files that I archived off and indexing new ones). I didn't have time to screw around with it and so started using copernicus -- which is nice, but it doesn't have the CTRL-CTRL invocation that I grew to love on GDS (but does have other nice features that GDS didn't have).
Or, if you are of a good alignment, you can put a potion of plain water on an altar of your aligned god and make a sacrifice of a corpse to generate any needed holy water (IIRC)....
Actually graft vs. host is due to lymphocytes of the donor attacking the cells of the recipient and does not directly have to do with blood volume (although obviously, the more blood you get, the more foreign lymphocytes you will get). In most people this is not a big deal b/c the immune system of the recipient can handle the foreign lymphocytes appropriately. However in immunodeficient individuals (or young people with underdeveloped immune systems) this is not good, since they do not have the ability to protect themselves against the donor immune cells.
As a side note - I've got so much overtime and vacation left that when I find a new job, I can leave the same minute and they still have to pay me for eight weeks.
Accumulating 8 weeks of vacation in US would be difficult, if not impossible, to do at most companies. My last gig did not even allow roll-over of vacation from year to year, and the vacation schedule was something along the lines of 1 week your first year, 2 until year 5, three from 6-10, (or something along those lines). To get eight weeks would generally take over 4 years (assuming roll overs are allowed, a two week vacation, and no vacation taken the rest of the year).
And what is this "overtime" that you speak of? I find your ideas intriguing and would like to subscribe to your newsletter...
Slashdot Mirror
Well let's see, a patient comes in with a complaint. The doctor forms a hypothesis as to what is causing the problem(s) based on the available data (presenting signs, symptoms, epidemiology, etc..). He/she then orders tests or medication to gather additional data to support or refute the hypothesis. Based on the data from the tests, he/she either forms a new/better hypothesis, or arrives at a probable diagnosis.
Yeah -- I guess you're right. That doesn't sound very scientific-methody at all~.
...Bomber pilots have a lower rate of death...
...Bomber crews, the safest group...
How do bomber pilots and bomber crews have different mortalities? They are in the same plane.
It's actually 2 free hours a day, which for one coffee of 15 dollars is really not too bad.
Fixed that for you. No charge.
Everyone knows that it is perfectly cromulant to brick something.
Remember, the noblest heart embrickens the smallest man.
It's a six digit ID. Who cares? :)
Next on Oprah! People who have been recruited by the Star League...
I for one haven't bought a new CD (or asked for one) since the whole Sony rootkit thing came out. I never used to be a huge purchaser, but maybe around 1-2 dozen a year. But now I seriously don't have time to keep track of which CD's are going to screw up my computer and which ones don't. I don't P2P either -- meh, I just don't care enough. There is more than enough music in my music library to keep me happy that I don't need the latest and greatest release.
Argh!!! Ze goggles! Zey do nussing!!!!
With that error, I think you would get the Yellow Screen of Death.
Blue screen of death would be for the lungs.dll.
Bravo, sir. Bravo! [applause]
Where may I subscribe to your newsletter?
Nerve fibers in the peripheral nervous system (PNS - formed by cranial and spinal nerves) have the potential for regrowing. How successful they are at regrowing depends on the type of injury. Apparently the myelin sheaths formed by Schwann cells in the PNS (which, among other things, speed up the nerve signal conduction velocity and decrease metabolic demands on the cell for signalling) can also help the nerve regenerate axons in the case of trauma. If the trauma is a crushing one, then the nerve cell body may have more of a chance of regenerating through the existing myelin sheath infrastructure. If the trauma is a severing variety, then the cell body will send out cellular processes to try to reconnect with its target. This reconnection may or may not be successful. However, it is possible for motor cells that signal to one muscle to re-enervate another muscle (e.g. jaw winking where jaw nerve muscles re-enervate the eye after injury).
Injury to the central nervous system (CNS - spinal cord and brain) is a much different story. Here, the nerves are precluded from reconnecting with their targets to due scar tissue laid down by normally supportive cells (astrocytes). Other supportive cells (oligodendrocytes and microglia cells) may also release inhibitory factors thus preventing CNS regeneration.
Cue the flock of doves...
Not sure if you know about this, but you may want to look into epigenetics. Basically, it involves mechanisms that affect DNA expression without altering the underlying DNA sequence. Epigenetic mechanisms have been identified in such things as hereditary nonpolyposis colorectal cancer (microsatellite instability due to DNA methylation changes) and I believe some imprinting diseases such as beckwith-wiedemann or angelman syndrome.
If you are interested in reading more, you may want to look at the following articles:
Epigenetics and human disease, Jiang YH, Bressler J, Beaudet AL. [PMID 15485357]
Epigenetic reprogramming and imprinting in origins of disease, Tang WY, Ho SM. [PMID 17638084 ]
An older reference:
Or this: [1] Myocardial reperfusion: a double-edged sword?: PMID 4056048
[2] Brain ischemia and reperfusion: molecular mechanisms of neuronal injury: PMID 11054482
Bacteria hate us for our freedom.
That is why it is so important that we ban dihydrogen monoxide. Everyone one who has used this terrible substance has eventually died!
Hi Tom! How is Katie doing? Got any new films in the works?
Nice!
Rubber ducky, you're the one
That makes oceanography so much fun....
This message brought to you by the number i.
Desktop search is priceless to me. I am in medical school and we have 99.9% of our lectures in PPT format. I take notes with openoffice. Being able to quickly search locally lets me easily find material from months ago to refresh my memory on it and also to integrate old information with new information.
That being said, I used google desktop for several months but then I started having problems with it updating its index (removing files that I archived off and indexing new ones). I didn't have time to screw around with it and so started using copernicus -- which is nice, but it doesn't have the CTRL-CTRL invocation that I grew to love on GDS (but does have other nice features that GDS didn't have).
Or, if you are of a good alignment, you can put a potion of plain water on an altar of your aligned god and make a sacrifice of a corpse to generate any needed holy water (IIRC)....
Only if it is intelligently designed.
Actually graft vs. host is due to lymphocytes of the donor attacking the cells of the recipient and does not directly have to do with blood volume (although obviously, the more blood you get, the more foreign lymphocytes you will get). In most people this is not a big deal b/c the immune system of the recipient can handle the foreign lymphocytes appropriately. However in immunodeficient individuals (or young people with underdeveloped immune systems) this is not good, since they do not have the ability to protect themselves against the donor immune cells.
This outs me as a complete nerd...but -- the second (i.e. not surprised) picture with the cut-and-paste eyes makes her look like a Gao'uld.
As a side note - I've got so much overtime and vacation left that when I find a new job, I can leave the same minute and they still have to pay me for eight weeks.
Accumulating 8 weeks of vacation in US would be difficult, if not impossible, to do at most companies. My last gig did not even allow roll-over of vacation from year to year, and the vacation schedule was something along the lines of 1 week your first year, 2 until year 5, three from 6-10, (or something along those lines). To get eight weeks would generally take over 4 years (assuming roll overs are allowed, a two week vacation, and no vacation taken the rest of the year).
And what is this "overtime" that you speak of? I find your ideas intriguing and would like to subscribe to your newsletter...