..laws dont get changed by people breaking them because they disagree with the law. change within the 'system'
I have to disagree with that. I've helped make quite a few, and if you start from your premise your bill will never make it out of the first committee in the long series it must pass thru.
Those who marshal their forces and alter the way things are done win way more often than those who try to put down one brick in the way of a flood. You need to use a dumptruck and divert the river further upstream, not in the wide plain right before it hits the houses.
This doesn't mean you shouldn't be placing the new channel parts before you divert all the river - you have to do the groundwork for a bill just like the new channel diversion trench, before you start dumping in rocks to choke out the old channel.
When you can just shut down the wall making machinery...
Well, it seems to me we live in a very passive generation of people, people who love Big Brother or Big Uncle and are afraid to stand up for what they believe in.
and out of 625 trials, 8 of them come up with something on the other end that isn't what it should be.
It could be that the source DNA or cDNA or RNA isn't what it was supposed to be.
It could be that the primers were - well - WRONG.
It could be that something inside your Cell-Free or standard E.coli that interacted with the siRNA or other fragments that just came along in the specific conditions you used.
Regardless, you know - because you checked and it is NOT the correct coded sequence - that it isn't the Open Reading Frame or variant you're looking for.
So, to be frank, you TOSS it.
This is good science. Not bad science. Something messed up. Now, if it happened a lot, the same way, then it IS something you should follow up on, but sometimes - frankly - stuff happens.
Maybe it was the sponsor who pointed it out. Is that BAD? They just want good results. The bad results have nothing to do with what you're studying.
So this could explain some of the results in this survey.
or let's think of a study to see if you can find crystals from proteins in a certain strain of Pfal, and you find that you can get crystals when you cross-express with the same primer in Pyoelli or Pberghei instead, so you change it so you find the structures that can crystallize which let you determine the common protein pathways instead of banging your head against a wall because you can't get anything to express.
Is that unethical or merely adapting to the realities of the world? If you end up with the same result, documented and proven by other labs due to peer review and other later studies, how is it bad to change?
In biochemistry you have to pay attention to the biology as well. Sometimes you may start with certain concepts which don't pan out, because you discover something even more interesting instead.
Kind of like the PhD from Cambridge here last month you started on a 2 year project to discover certain things and ended up spending 20 years, but discovering - get this - a cure for 50 percent of all known cancers.
Is it bad that at many points he changed from his simple model of how the pathways worked? Or is it good that he listened to the science and the biochemistry and the biology and followed the much more complex regulatory systems that actually existed and found the cure for half of all cancers?
Not everyone is measuring light emissions in astronomical labs. Some of us deal with the real world. If it hadn't been for someone noticing the connection with bat caves, we wouldn't have vaccines in trials for Ebola and Marburg today.
what did you want, more lawyers or politicians or investment brokers instead?
Geesh! Get real - if it weren't for scientists, most of Africa would have died off from AIDS/HIV and we wouldn't have vaccines for Ebola and Marburg virus today.
Scientists and Engineers are all that keep the wolves from your door.
After all, since everyone used to do that in the 90s and blame those in the White House and President for such things, I figure it must be the current occupants' examples of unethical behavior.
Tsk. I remember when Truth, Justice, and the Scientific Way were hallmarks of America, last century. Not now.
They'd be super cool, all the high school and college and university crowd have them and use them, and you could sell them as add-ons that have cool color or logo schemes - like Pokemon electric yellow with a Pikachu graphic one, or Luminescent transparent green with sparkles, or Ruby red lipstick (which actually looks like one), or whatever.
Only 1uz3rz use real HDD. Everyone else has moved on already - it's the 21st Centure, for godsake.
Here at the UW it's way more fun. But that's why we're number one for Medical post-grad and number four for Biochem post-grad.
Of course, as you may realize, 90 plus percent of the people here think Bushies are brainless, but that's just because this is where fiscal discipline is cool and lying is uncool.
If Apple is willing to embrace the Intel architecture because of its performance and low power consumption, then why not go with AMD, which equals Intel's power specs, EXCEEDS Intel's performance specs AND does so at a lower price point across the board? Apple and AMD makes far more sense than Apple and Intel any day.
See, that's the first question I would have asked. Perhaps he's right and the execs at both companies have arranged a stock-for-stock swap and aren't admitting to it until they have all their ducks lined up in a row...
because real staff at universities carpool, bike, walk, or bus. you probably get really cheap rates for bus passes too - mine are 40 cents a trip, which is about a fourth the going rate.
if you're driving to work, you're doing something wrong.
1: Office Politics in education are an absolute bitch! And while any smart person would want to stay out of them entirely, you can get easily fired for not playing the game if you do.
2: If you're a conservative, keep it to yourself ALWAYS! If you're a liberal (somewhere to the left of Howard Dean) then it's okay to speak carefully and discreetly -- and after everyone else has had their say first.
3: You are in the absolute bastion of Political Correctness. A lot of it will be abysmally stupid. Don't ever point that out to ANYONE! Just nod silently and move along. There's nothing you can do about it anyway.
4: You are in the breeding ground for sexually harassed females in training. Be as respectful to any female -- especially any unattractive female -- as you are to the cop who just pulled you over for doing 50mph in the school zone just as the last points were about to drop off your license.
5: Diversity good! Affirmative Action good! Repeat this loud and often. And never forget that "Diversity" doesn't really mean true diversity. It means their one and only single definition of diversity.
Um, dude, you must work in one strange university.
As to being conservative, it's only the fake conservatives like the Bushies that get laughed at and ridiculed.
And there's way more diversity here than elsewhere. Again, maybe you're kind of uptight? But again, maybe you work at Harvard, that's kind of like that.
1. Respect the heirarchy. This is critical. 2. There's free stuff everywhere when labs and depts move - and then there's surplus for sale too. 3. Investigate the benefits ASAP - I got matching retirement pay the second I wanted it and signed up on week one - others waited two years for some reason. 4. Be friendly to everyone.
Knowing many people who still work at the higher ed levels (doing programming and tech suppot), its like a regular job. 9-5. In fact, I'm thinking about getting back into the uni game after going corporate . Much more relaxing. Though, none of the people I know participate in the "parties" or "drunk sorority chicks" (thats assault brotha). Easygoing private schools or big public schools are a nice area, plenty to do, but easy going. At least thats been my expirence. Hey, try it out, the time is around now for unis to be hiring.
Um, well, maybe for you. It depends what level of staff you are - I'm in the same category as the Profs, so I tend to work 9-10 hours a day (or else work 8 hours and come in weekends) and some weekends are conferences.
But I agree about the stress - this is the most fun job I've had since the military. The pay's not quite as high, but the benefits are so cool as to blow your mind - in a typical week I get to go to free seminars about cutting edge stuff you won't see for months out in the commercial side, have free tuition towards my doctorate (except the last year, but hey), and the 40 cents a trip university bus pass rocks my world!
Plus all the intelligent women one could dream of! From around the world! Life is sweet!
I telnetted it in with a direct cable back in 1999, so I sure hope it's one of my standard ones, cause if I ever have to upgrade my router, it's gonna be heck to pay.
Write them down in code form - use a series of uncommon words - like say Hindi versions of Innuvut food (not known by many) - and a series of numeric and symbolic entries - and you defeat almost any cracking scheme. Then just write down a pattern - say xxxxxYY to indicate SGIAN87 where you know what the xxxx is likely to be and the YY is likely to be - and store that part somewhere else. Don't tape it to the bottom though.
Thanks for bringing up needlepoint, that's a great example of what the parent is talking about.
Doing needlepoint is more akin to using a stylus--you're using an object with a very fine resolution point to put something precisely where you want it.
The first touchscreen I ever saw was one used by a friend of mine - an HP system which one tended to use a stylus to get finer control with, if you didn't want to use the connected stylus drawing pad.
You can wear a stylus on your fingertip, use a rubber-tipped pencil, or a Palm stylus if that's what works, but I still think telepathy is best.
Except that Big Uncle then reads my innermost thoughts.
1. Your finger has very low resolution. You cannot position something very precisely with a finger on the screen no matter how sensitive the touch screen is.
I'll tell all the people who have done needlepoint thruout the millenia that they don't exist then.
Just because you can't do it, doesn't mean it can't be done.
and thus input directly by firing my neurons in gross motor movement, instead of using the headset interface to communicate telepathically because I hate the fact that Big Uncle is watching.
There's a reason why Pfizer and other companies took action on spam, because I figured out who the corporate people were who legally had to take action to defend their trademarks and service marks and patents when I got spam selling fakes of their products....
Most IPOs have a big drop at the lockup expirations which are usually at the 90, 120, and 180 day periods after the IPO is issued.
Keep that in mind if you're shorting - which is buying an option to sell stock at a lower price than the current price at a fixed date in the future.
Of course, when you short, realize someone bought the other end of the option and is betting against you. The only person who always makes money on options is the brokerage firm and/or broker.
Like privately held debt, Google must pay interest on the stock they issued. Those are called dividends. Additionally, Google may have to buy back shares at some point. Stock != value. Stock == debt. Earnings == value. Plain and simple.
Actually, a BOND is a debt. A Stock is a share in both the assets - and DEBTS - and potential earnings and losses, capped at a maximum loss of the total value invested (translation - you can only lose what you paid, no more).
A Stock has (optional) Dividends, which may or may not coorelate with earnings, but are usually a fraction as some money is saved in Cash (Google has lots), stolen.. um... paid (whatever) to executives in options to dilute other owners or pensions to dilute future earnings or salaries to just make you angry or loans (rarely repaid) to make you hopping mad, and the stock price is an estimatation by the totality of the market as to what the company will be worth in current and future earnings and returns on investment. In general a stock price is close to, but not the same as, a bet on the worth of a company in six to twelve months from now, but in some cases - such as Google - this estimate is a lot of hooey or fluff.
As an example, take my holdings in EBAY - which is highly speculative, so I've only got $4000 in that - it's based on a projected growth rate of DOUBLE what GE will make in the same 2-5 year growth pattern. Who knows if it's true? Noone.
Now, if you'd like to talk Bonds (DEBT), or Options (Risky Bets on the Future Price of a Stock), or Preferred Stocks, we could do so.
Regardless, Google is not worth more than the EU, no matter how you slice it. No matter what price fools... um... investors are willing to pay for it TODAY.
Slashdot Mirror
..laws dont get changed by people breaking them because they disagree with the law. change within the 'system'
I have to disagree with that. I've helped make quite a few, and if you start from your premise your bill will never make it out of the first committee in the long series it must pass thru.
Those who marshal their forces and alter the way things are done win way more often than those who try to put down one brick in the way of a flood. You need to use a dumptruck and divert the river further upstream, not in the wide plain right before it hits the houses.
This doesn't mean you shouldn't be placing the new channel parts before you divert all the river - you have to do the groundwork for a bill just like the new channel diversion trench, before you start dumping in rocks to choke out the old channel.
When you can just shut down the wall making machinery ...
Well, it seems to me we live in a very passive generation of people, people who love Big Brother or Big Uncle and are afraid to stand up for what they believe in.
I refuse to live in Fear.
and out of 625 trials, 8 of them come up with something on the other end that isn't what it should be.
It could be that the source DNA or cDNA or RNA isn't what it was supposed to be.
It could be that the primers were - well - WRONG.
It could be that something inside your Cell-Free or standard E.coli that interacted with the siRNA or other fragments that just came along in the specific conditions you used.
Regardless, you know - because you checked and it is NOT the correct coded sequence - that it isn't the Open Reading Frame or variant you're looking for.
So, to be frank, you TOSS it.
This is good science. Not bad science. Something messed up. Now, if it happened a lot, the same way, then it IS something you should follow up on, but sometimes - frankly - stuff happens.
Maybe it was the sponsor who pointed it out. Is that BAD? They just want good results. The bad results have nothing to do with what you're studying.
So this could explain some of the results in this survey.
or let's think of a study to see if you can find crystals from proteins in a certain strain of Pfal, and you find that you can get crystals when you cross-express with the same primer in Pyoelli or Pberghei instead, so you change it so you find the structures that can crystallize which let you determine the common protein pathways instead of banging your head against a wall because you can't get anything to express.
Is that unethical or merely adapting to the realities of the world? If you end up with the same result, documented and proven by other labs due to peer review and other later studies, how is it bad to change?
In biochemistry you have to pay attention to the biology as well. Sometimes you may start with certain concepts which don't pan out, because you discover something even more interesting instead.
Kind of like the PhD from Cambridge here last month you started on a 2 year project to discover certain things and ended up spending 20 years, but discovering - get this - a cure for 50 percent of all known cancers.
Is it bad that at many points he changed from his simple model of how the pathways worked? Or is it good that he listened to the science and the biochemistry and the biology and followed the much more complex regulatory systems that actually existed and found the cure for half of all cancers?
Not everyone is measuring light emissions in astronomical labs. Some of us deal with the real world. If it hadn't been for someone noticing the connection with bat caves, we wouldn't have vaccines in trials for Ebola and Marburg today.
Thanks, it's good to know someone realizes the true statistics - this is a far more honest profession than accountants for example.
what did you want, more lawyers or politicians or investment brokers instead?
Geesh! Get real - if it weren't for scientists, most of Africa would have died off from AIDS/HIV and we wouldn't have vaccines for Ebola and Marburg virus today.
Scientists and Engineers are all that keep the wolves from your door.
After all, since everyone used to do that in the 90s and blame those in the White House and President for such things, I figure it must be the current occupants' examples of unethical behavior.
Tsk. I remember when Truth, Justice, and the Scientific Way were hallmarks of America, last century. Not now.
so reboot from your flash drive with a new Linux OS then.
...
geesh, it's not exactly hard to do
They'd be super cool, all the high school and college and university crowd have them and use them, and you could sell them as add-ons that have cool color or logo schemes - like Pokemon electric yellow with a Pikachu graphic one, or Luminescent transparent green with sparkles, or Ruby red lipstick (which actually looks like one), or whatever.
Only 1uz3rz use real HDD. Everyone else has moved on already - it's the 21st Centure, for godsake.
truth is stranger than fiction, or certain cartoon network TV shows.
you guys both work at Harvard?
geesh.
Here at the UW it's way more fun. But that's why we're number one for Medical post-grad and number four for Biochem post-grad.
Of course, as you may realize, 90 plus percent of the people here think Bushies are brainless, but that's just because this is where fiscal discipline is cool and lying is uncool.
Hey, nothing a little fair market reforms can't handle, all in the spirit of true capitalism, no?
....
Wonder how much I can get for all those hundreds of AOL CDs I use for coasters
Question 3: Where the heck is AMD?
...
If Apple is willing to embrace the Intel architecture because of its performance and low power consumption, then why not go with AMD, which equals Intel's power specs, EXCEEDS Intel's performance specs AND does so at a lower price point across the board? Apple and AMD makes far more sense than Apple and Intel any day.
See, that's the first question I would have asked. Perhaps he's right and the execs at both companies have arranged a stock-for-stock swap and aren't admitting to it until they have all their ducks lined up in a row
because real staff at universities carpool, bike, walk, or bus. you probably get really cheap rates for bus passes too - mine are 40 cents a trip, which is about a fourth the going rate.
if you're driving to work, you're doing something wrong.
1: Office Politics in education are an absolute bitch! And while any smart person would want to stay out of them entirely, you can get easily fired for not playing the game if you do.
2: If you're a conservative, keep it to yourself ALWAYS! If you're a liberal (somewhere to the left of Howard Dean) then it's okay to speak carefully and discreetly -- and after everyone else has had their say first.
3: You are in the absolute bastion of Political Correctness. A lot of it will be abysmally stupid. Don't ever point that out to ANYONE! Just nod silently and move along. There's nothing you can do about it anyway.
4: You are in the breeding ground for sexually harassed females in training. Be as respectful to any female -- especially any unattractive female -- as you are to the cop who just pulled you over for doing 50mph in the school zone just as the last points were about to drop off your license.
5: Diversity good! Affirmative Action good! Repeat this loud and often. And never forget that "Diversity" doesn't really mean true diversity. It means their one and only single definition of diversity.
Um, dude, you must work in one strange university.
As to being conservative, it's only the fake conservatives like the Bushies that get laughed at and ridiculed.
And there's way more diversity here than elsewhere. Again, maybe you're kind of uptight? But again, maybe you work at Harvard, that's kind of like that.
1. Respect the heirarchy. This is critical.
2. There's free stuff everywhere when labs and depts move - and then there's surplus for sale too.
3. Investigate the benefits ASAP - I got matching retirement pay the second I wanted it and signed up on week one - others waited two years for some reason.
4. Be friendly to everyone.
Knowing many people who still work at the higher ed levels (doing programming and tech suppot), its like a regular job. 9-5. In fact, I'm thinking about getting back into the uni game after going corporate . Much more relaxing. Though, none of the people I know participate in the "parties" or "drunk sorority chicks" (thats assault brotha). Easygoing private schools or big public schools are a nice area, plenty to do, but easy going. At least thats been my expirence. Hey, try it out, the time is around now for unis to be hiring.
Um, well, maybe for you. It depends what level of staff you are - I'm in the same category as the Profs, so I tend to work 9-10 hours a day (or else work 8 hours and come in weekends) and some weekends are conferences.
But I agree about the stress - this is the most fun job I've had since the military. The pay's not quite as high, but the benefits are so cool as to blow your mind - in a typical week I get to go to free seminars about cutting edge stuff you won't see for months out in the commercial side, have free tuition towards my doctorate (except the last year, but hey), and the 40 cents a trip university bus pass rocks my world!
Plus all the intelligent women one could dream of! From around the world! Life is sweet!
See, I told you Open Source was slower than Closed Source!
...
Um, when were MSFT going to release that patch for IE? Next century?
.
.
. now where's that irony key on my keyboard
I telnetted it in with a direct cable back in 1999, so I sure hope it's one of my standard ones, cause if I ever have to upgrade my router, it's gonna be heck to pay.
Write them down in code form - use a series of uncommon words - like say Hindi versions of Innuvut food (not known by many) - and a series of numeric and symbolic entries - and you defeat almost any cracking scheme. Then just write down a pattern - say xxxxxYY to indicate SGIAN87 where you know what the xxxx is likely to be and the YY is likely to be - and store that part somewhere else. Don't tape it to the bottom though.
Thanks for bringing up needlepoint, that's a great example of what the parent is talking about.
Doing needlepoint is more akin to using a stylus--you're using an object with a very fine resolution point to put something precisely where you want it.
The first touchscreen I ever saw was one used by a friend of mine - an HP system which one tended to use a stylus to get finer control with, if you didn't want to use the connected stylus drawing pad.
You can wear a stylus on your fingertip, use a rubber-tipped pencil, or a Palm stylus if that's what works, but I still think telepathy is best.
Except that Big Uncle then reads my innermost thoughts.
1. Your finger has very low resolution. You cannot position something very precisely with a finger on the screen no matter how sensitive the touch screen is.
I'll tell all the people who have done needlepoint thruout the millenia that they don't exist then.
Just because you can't do it, doesn't mean it can't be done.
and thus input directly by firing my neurons in gross motor movement, instead of using the headset interface to communicate telepathically because I hate the fact that Big Uncle is watching.
Does that make it better? Or just different?
There's a reason why Pfizer and other companies took action on spam, because I figured out who the corporate people were who legally had to take action to defend their trademarks and service marks and patents when I got spam selling fakes of their products ....
Action, not excuses.
Most IPOs have a big drop at the lockup expirations which are usually at the 90, 120, and 180 day periods after the IPO is issued.
Keep that in mind if you're shorting - which is buying an option to sell stock at a lower price than the current price at a fixed date in the future.
Of course, when you short, realize someone bought the other end of the option and is betting against you. The only person who always makes money on options is the brokerage firm and/or broker.
Like privately held debt, Google must pay interest on the stock they issued. Those are called dividends. Additionally, Google may have to buy back shares at some point. Stock != value. Stock == debt. Earnings == value. Plain and simple.
.. um ... paid (whatever) to executives in options to dilute other owners or pensions to dilute future earnings or salaries to just make you angry or loans (rarely repaid) to make you hopping mad, and the stock price is an estimatation by the totality of the market as to what the company will be worth in current and future earnings and returns on investment. In general a stock price is close to, but not the same as, a bet on the worth of a company in six to twelve months from now, but in some cases - such as Google - this estimate is a lot of hooey or fluff.
... um ... investors are willing to pay for it TODAY.
Actually, a BOND is a debt. A Stock is a share in both the assets - and DEBTS - and potential earnings and losses, capped at a maximum loss of the total value invested (translation - you can only lose what you paid, no more).
A Stock has (optional) Dividends, which may or may not coorelate with earnings, but are usually a fraction as some money is saved in Cash (Google has lots), stolen
As an example, take my holdings in EBAY - which is highly speculative, so I've only got $4000 in that - it's based on a projected growth rate of DOUBLE what GE will make in the same 2-5 year growth pattern. Who knows if it's true? Noone.
Now, if you'd like to talk Bonds (DEBT), or Options (Risky Bets on the Future Price of a Stock), or Preferred Stocks, we could do so.
Regardless, Google is not worth more than the EU, no matter how you slice it. No matter what price fools