Primordial Soup: Interview with Stanley Miller
An anonymous reader writes "Stanley Miller's classic 'primordial soup' experiments showed that 13 of the 21 amino acids necessary for life could be made in a glass flask. For its fifty-year commemoration, Miller is interviewed today and reflects on what Carl Sagan
called 'the single most significant step in convincing many scientists that life is likely to be abundant in the cosmos.'"
showed that 13 of the 21 amino acids necessary for life could be made in a glass flask
:-)
Of course, certain products of his experiments often indicate that not all of them are necessary. These products are, of course, "intellectual property lawyers."
Do you like German cars?
It hardly needs saying, but in a week I didn't make any amino acids I could detect. Nevertheless, I ended up getting a shockingly high mark because I'd written up every possible reason I could think of for the experiment failing: not enough time, not enough interaction between liquid and gas, not enough energy from the light, test wasn't sensitive enough, Miller had faked his results (ha!), etc. I was disappointed in the results, but pretty happy with my mark. :-)
Carousel is a lie!
Primordial Recipe: Spark and Stir
Date Wednesday, May 14 @ 00:48:06
Topic Extrasolar Life
No single experiment, according to Carl Sagan, has done more to convince scientists that life is 'likely abundant in the cosmos' than the work fifty years ago by then graduate student, Stanley Miller. This week celebrates his milestone publication, and Astrobiology Magazine interviewed him about his work and reflections today.
Primordial Recipe: Spark and Stir
by Astrobiology Magazine staffwriter
Fifty years ago on May 15, 1953, a University of Chicago graduate student, Stanley Miller, published a landmark two-page paper in Science magazine. He considered if amino acids could be made from what was known about the early Earth's atmosphere. Could the building blocks of life be cooked up?
"... some warm little pond, with all sorts of ammonia and phosphoric salts, light, heat, electricity etc...", Charles Darwin, on the origins of life in tidal pools
Credit:Smithsonian
Miller began his paper:
"The idea that the organic compounds that serve as the basis of life were formed when the earth had an atmosphere of methane, ammonia, water and hydrogen instead of carbon dioxide, nitrogen, oxygen and water was suggested by Oparin and has been given emphasis by Urey and Bernal. In order to test this hypothesis..."
When Miller first presented his experimental findings to a large seminar, it is reported that at one point, Enrico Fermi politely asked if it was known whether this kind of process could have actually taken place on the primitive Earth. Harold Urey, Stanley's research advisor, immediately replied, saying 'If God did not do it this way, then he missed a good bet'. The seminar ended amid the laughter and, as the attendees filed out, some congratulated Stanley on his results.
Although Miller had submitted his paper in mid-December 1952, one reviewer did not believe the results and delayed its publication until May 15th. Later Carl Sagan would do many experiments varying the chemical percentages, but described the Miller-Urey experiments as "the single most significant step in convincing many scientists that life is likely to be abundant in the cosmos."
Early Earth: Flash in a Flask
Even today, only a few definitive things are known about what the Earth might have been like four billion years ago. It is thought that the early sun radiated only 70 percent of its modern power. No free oxygen could be found in Earth's atmosphere. The rocky wasteland lacked life. Absent were viruses, bacteria, plants and animals. Even the temperature itself is uncertain, since three schools of thought today maintain that the Earth could have been alternatively frozen, temperate or steamy.
Charles Darwin imagined life springing from a temperate world, with small ponds or runoff channels. Compared to diluted chemistry in a vast ocean, repeated evaporation and refilling have possible advantages, to find just the right concentrations somewhere so that biochemistry could begin. Glaciers, volcanoes, geysers and cometary debris potentially resupplied this primordial pond with both energy and more complex organic compounds. That is a scenario requiring relatively temperate starting conditions, and more extreme possibilities are also in the mix.
If the early Earth was a cauldron of volcanic activity, then seepage of acidic gases and heating might have circulated vital compounds to the surface. These vents may have been underwater, and precursors to biochemistry like acetic acid may have become reactive in combination with carbon monoxide. Alternatively, if the early Earth lacked any greenhouse of blanketing carbon dioxide, life could still have begun in a ball of ice. When combined with water, even a thin atmosphere of organics (formaldehyde, cyanide and ammonia) can create some building blocks of life (such as the amino acid, glycine). Thawing this 'snowball Earth' could then be triggered by a chance collision with large comets or meteors.
Terrestrial options for ea
By the way, in the Slasdot posting, why isn't the word interview linked to the story?
Miller had an unknown aide during this project. He spent a lot of time working with the fledgling life forms as they formed a society and culture. They became to see him as a God, and worship him.
One fateful day, they managed to shrink the aide using a debigulator device, so he could lead their civilization. When he demanded they unshrink him, they were indeed astounded by the very notion of a re-bigulator device.
True story.
"I only speak the truth"
Karma: null(Mostly affected by an unassigned variable)
I stopped eating primordial soup because the amino acids keep giving me heartburn.
All your base are belong to us!
from October 1996: Exobiology interview
On a related note: exobiology vs astrobiology? which do people prefer? (The definitions are in the links)
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You didn't have a way of zapping the gases?
Your biochem teacher didn't offer to help?
At the very least, the school Van de Graaf generator might have helped.
I really hope you didn't put down "faked his results" as that would've shown shocking lack of research into the followups to his experiments.
Test not sensitive enough seems reasonable. Perhaps you could've looked up the concentrations he got, versus the sensitivity of your test.
For two years, I bugged my Biology teachers to let my try the Miller experiment with the school's equipment. (Of course, I was the same one who wanted them to let me make a gauss rifle, a betatron, and potato gun...)
I remember being fascinated when I first heard of the experiment. It seemed so 'important,' despite the fact that they brushed right over it and no one else in my classes understood or cared.
Of course, now I'm in college, and I can try all of these things with my own equipment.
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Mmmm... Miller-Ade...
...broke down as fast as they were made (in a carefully customised device, not in the wild), and were completely racemised at formation? Or that no evidence of a reducing atmosphere exists?
Just like every other fairy tale: exciting, adventurous, believable, and wrong.
Got time? Spend some of it coding or testing
I've duplicated his results in my refridgerator and now have some primordial soup in there. It's chicken noodle primordial soup and tastes great with fresh baked bread.
I'm trying to teach myself to set people on fire with my mind... Is it hot in here?
Would the experimentor claim intellectual property rights to the amino acids he found? "Sorry you can't use those drugs, I own the rights to all life on this planet."
Outdoor digital photography, mostly in New Engl
Wrong! You are plain wrong. Sod off back under your bridge in Arkansas, troll!
Stick Men
You're whining that the odds are too big, but it's guys like Stanley Miller that are trying to figure out exactly how big those odds are.
You might want to actually provide some facts as to why Carl Sagan was wrong, rather than make an ad hominem attack. Most truly academic scientists generally take a bit more convincing than just being told that, "The guy was an asshole, so he must be wrong."
to somehow make a "food pill" with amino acids? Would definately help in dealing with the fat America problem. I know there are non-Amino acid products in the food we eat that we need, but there could be some definate advantages in not having/lessened need to eat. Think "feeding the hungry for a week with a single can of super cola".
The preceding post was not a Slashvertisement.
Actually he wrote it down in the book "Contact" and Jodie Foster used it in one of her "dramatic moments"
Yell & scream & rant & rave... it's no use... you need a shaaaave ~ Bugs Bunny
u know u can make an entire human baby in a test tube.
for the last time people, I am "frodo from middle eaRTH", not "middle eaST".
It was my understanding that there is more than enough organic chemistry in comets to seed the early earth with the necessary components. Or at least, it would be a significant fraction, since the early earth would have had a lot of collisions from interplanetary debris. We find lots of interesting chemicals in asteroids and comets.
I guess the question is to what extent did this seeding speed the development of life: would the chemistry have developed without a steady rain of complex molecules from the heavens?
(puts you in the mind of early myths of a Sky God impregnating an Earth Godess)
I've got a bad attitude and karma to burn. Go ahead. Mod me down.
As a student of Biological Anthropology, I have had the oppertunity to take a history of biological anthropology in which Miller was mentioned. Interesting guy, but the theory is not supported any more except by the few staunchest researchers. In other words, this is pop science. It survives in text books (like many other evolutionary inaccuracies that nobody seems to be willing to update). In truth, the experiment did not conclude much. In short, the amino acid theory in reality did not produce very much at all. Still, Miller dared to try it, which is a feat in itself. Update those textbooks! Include him in the history section, but his theory is not much good anymore.
Er, Jodie Foster was not in the book "Contact."
"Lottery = your chances in getting picked out the pool may be one in a million, but your chances of picking the right number on the right day and being that one in a million are impossible odds"
No. It's still one in a million. The odds determined here are that your number, one number out of a million choices, is randomly chosen as the winner. There are one million possibly outcomes. It doesn't matter which number you choose (multiple winners and real-world lottery bullocks like that aside).
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Late Night Radio for Geeks!
And until the little green (gray, blue, orange, who cares) men show up, or at least until we find something extra-terestrial (by definition, not of Earth) on Mars, Ganymede, or the like, there will never be 100% proof.
The only thing we have right now is conjecture and probabilities. Probability would say that, yes we may be the only intelligent life forms in our arm of the galaxy. But you'd have to be awful damn arrogant to say we ARE the ONLY intelligent life.
I give the SETI people credit for the attempt; but, I don't believe that their project, because of it's limited scope, will bear fruit. They are only looking within the near 50-150 light years or so. Beyond that, the signals are too weak and the time-lag would make communication impossible beyond "Hey, we're over here."
the single most significant step in convincing many scientists that life is likely to be abundant in the cosmos
I hate to disappoint you but you will not be drinking coffee with some green men anytime soon. I guess this story will be a classical debate between creationists and evolutionists, personally I think God made this vast universe as a gigantic theatre for us to perform. why waste all that space you may ask? a simple quick answer is because he can, when you examine how beautiful and enormous this universe you should conclude how mighty and great is the creator. And another thing if we are simply a product of some physical phenomena why are we concise? why are we self-aware ? and why there is no other life form which is radically different from us (for example not carbon based)? We me be able to clone a human, or genetically alter a creature to create a new species but we certainly can't give life to something dead. I challenge anyone to explain to me why we die? if you took a cell from the brain of a dying person, and from his heart, lung, and every organ you can sustain them way after the original person dies so what made his/her system shutdown globally? and for the atheist masses out there YES we have soul and I cant prove it as much as you cant prove the opposite.
I don't think he was whining ... and how do you calculate the incalculable?
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Read for Comprehension ...
I'll take it with wanton sauce please.
I strongly feel that there are many planets harboring life in the galaxy. Consider this: what are the planets that we can directly observe to test for life? Clearly only those in the solar system. What have we found? It is thought to be a significant possibility that Mars had primitive life at some point in the past. Of course, the earth itself must be discounted because of the anthropic principle: if there weren't life on earth we wouldn't be around to ask the question. So out of a single observable planetary system we find one planet with the possibility of life. While this isn't statistically significant, it does makes it very unlikely that we are the only planet with life on it.
Education should provoke thought. Just training kids to pass tests is of no value. What you did, analysing your results and thinking about _why_ you got them shows far more 'talent' than someone who just repeated an experiment that is guaranteed to give good results.
Sigh! Rant over. It is just crushing to see very little evidence of people designing their science lessons to impart the ability to think, like the guy who wrote Clouds in a Glass of Beer did.
Help children born unable to swallow - www.tofs.org.uk
Actually, he was wrong. The experiment's controled variables from the onset changed the odds, but this was not reflected in his research. Furthermore, the odds of formation over disentegration are unfortunately impossible. This is NOT a supported theory today in the biological field. Miller was not an asshole; he was a bright guy, but the primordial soup is no longer the thoery most researchers support (there will always be a few, but there are still archeologists who swear by Atlantis).
I'm more Christian than chemist, I'm afraid, but I'd thought that Miller's experiments were among the easier targets for creationists to dismiss. While Miller's experiments may yet offer clues for life's origin, later research demonstrates without question that the origin problem is much more complex than pop scientists like Sagan seemed to believe.
If life is that common, where is everybody?
If my teacher had helped, it wouldn't have been my chemistry project, would it?
And no, I did not put down "faked his results." That pinging noise was your humour detector going off.
Carousel is a lie!
Damn stuff is so primitive it only has 'A's. You can only get a third of the way through spelling 'ASS' and forget about even trying 'POO.' It ain't gonna happen.
Is that they forget to add the red phosphorus and iodine to the mix.
This is the experiment I use to argue with creationists. They always say where did life come from and I point them towards this.
THe thing with creationists is that they are always forcing evolutionists to defend their theory and if they can't they use the god by default argument which is basically if you can't explain something, there must be a god. Thats the sort of reasoning that the indigineous cultures used.
Next time you are talking to a creationist, make them defend there belief. Aks them where god came from or something similar.
-- Karma Karma Karma Karma, Karma Chameleon - Boy George
how do you calculate the incalculable?
Who says that it's incalculable, and where's the evidence to back that up? My point was that it's easy enough to sit back and say that something's impossible, but it takes a bit more effort to try and figure out whether it's (maybe just remotely) possible.
You're saying there's measurable odds in picking the right number on the right day? You need to work for political polling in the next election, they'd love that skewed remark as an interview answer.
If you're claim things like that, then lets have a reliable source please. A google for "stanley miller" racemized gives 5 results, all for Creationists' pages.
broke down as fast as they were made
What does this mean? Do you mean that they existed for zero time (impossible?), that their breakdown process lasted as long as their creation process (meaningless?), that as more amino acids were created an equal number broke down (not much of a criticism?)
Thanks, that was a good counter arguement, eventhough I didn't try to make the points I was accused of making "creationism" and "only life here" more "and or" and "validity"
I had an idea as soon as I posted it I would get flamebait, eventhough I hate the negative moderation.
I do give space exploration and astronomy big kudos even more so BECAUSE of my arguements. Lots of great advances have been made due to SETI reasearch and space/life expoloration missions.
yeah, but what if the numbers on the lottery ticket you bought match last week's numbers, but not this week's numbers??
What would Brian Boitano do?
funny ... I tried something similar .... couldn't find any legitimate valid sources for an english paper I had to write in high school, so I combined a healthy dose of BS with an even healthier dose of good ole-fashioned humor.
:-p
However, unlike your teacher, mine had a sense of humor. I was pretty happy with the results, she gave me an A and said it was the most enjoyable paper that anyone in the class had turned in. Really changed my view of writing too.
Then, I spose that's also the difference between science and art, or maybe just between high school and the real world, or something.
The chemical was ninhydrin. Reacts with primary amines to give a purple spot on TLC.
Glass is a good blocker of UV. That's why one uses quartz cuvettes to determine the UV spectra of solutions from ca. 400 down to ca. 200 nm. I suspect this is where the good high-energy UVs that might have given you some chemical reactions are.
If Slashdot were chemistry it would look like this:Cadaverine
"Contact" [geocities.com] gave him a little recognition only because the movie was made believable (and bias I might add)
What? Are you suggesting that the movie Contact, which was a fun movie, but also new age UFO-cult pop drivel, led to Carl Sagan being more respected among SCIENTISTS?
Contact was BIASED? It's a work of fiction! What shortcomings of impartiality did you detect?
Most TRUELY academic scientists will tell you there seems to be "some" evidence of a creator
Well, Carl Sagan, it is true, is not as highly regarded for his own, unique, scientific contributions as one might believe watching PBS.
However, he had mountains of respect compared to anyone who pointed to anything specific and said it was evidence for the existence of a creator. It is perfectly well regarded in respected circles to quote Einstein "I believe in Spinoza's God who reveals himself in the orderly harmony of what exists", particularly if you are being harassed by religious nuts about your own beliefs - volunteering such sentiments in a TRUELY ACADEMIC setting is the mark of a crackpot, however.
To say that any particular observed phenomenon is evidence, however indirect or minor, of some sort of supernatural providence which exceeds our capacity to understand is the mark of a TRUELY desperate religious nut - not a TRUELY academic scientist.
Lottery = your chances in getting picked out the pool may be one in a million, but your chances of picking the right number on the right day and being that one in a million are impossible odds.
I'm a bioinformatician - you may be attempting to communicate something valid, but what you say is nonsense. If your odds of getting picked in a lotterry are one in a million, and you enter the loterry once, you have a one in a million chance of winning the loterry. If you have to enter the single, right loterry, and there are a million of them, the odds are one in a trillion (a million squared.) In any case, not "incalculable."
If you enter the loterry every day for a billion years and have a chance of winning each time, even vanishingly small odds
Furthermore, while it is true that the odds of life arising around any given star may be extremely small, even over a billion year timespan - Sagan's point remains valid, there are about a SEXTILLION (that's ten ^ 21) stars in known universe.
The reason that we don't have enough information to calculate the odds of life arising on an earth-like planet is because we don't have enough information. The one earth-like planet we observe, the Earth, has life on it, but we're here, so our single observation is hopelessly biased.
On the other hand - unless they are "TRUELY academic" - most scientists feel that life arose as a purely chemical process, from chemical laws which were the same at that time as they are today.
Now, we don't yet know all of the steps that need to occur in order for life to arise. However, even given our broad ignorance, we can conclude that you need organic monomers of some kind (assuming organic life such as ours - an entirely seperate question) is Step 1.
Whatever the probability of success of steps 2...n, the more likely you are to succeed at Step 1, the more likely the entire process is to succeed.
Stanley Miller showed that there conditions, conditions not inconceivable on a young, earthlike planet, under which the formation of these molecular monomers is highly likely.
Therefore, the entire series of steps becomes more likely. Groundbreaking work.
Not a single scientists has been able to prove 100% that life exists elsewhere, only propoganda and conjecture.
Entirely true. We may very well be alone in the universe. However, our best estimate is that we are not. Conjecture, yes, propoganda - only in so far as all scientific endeavor is propoganda against superstitious beliefs.
The good and new comes from no quarter where it is looked for, and is always something different from what is expected.
A large flask maybe, but I don't think you can fit a human baby in a test tube.
"We make our world significant by the courage of our questions and by the depth of our answers." Carl Sagan
Then you've picked the wrong numbers.
Why is this so hard to understand? There are 49x48x47x46x45x44 = 110,068,347,520 possible strings of six lottery balls. Divide by 6! because the order in which they appear doesn't matter. That's 13,983,816 possible sets of lottery numbers. You have picked one of these. Therefore, your chance of winning the lottery on any given draw is one in 13,983,816.
Of those 13,983,816 possible combinations, one is this week's winner, another is last week's winner, another is next week's winner: in fact, every winning lottery draw in history was one of those 13,983,816. But that makes no difference at all. You know that one and only one combination will be the winner. You pick one, and if it's the right one, you win. That's all there is to it.
Real Daleks don't climb stairs - they level the building.
From what I recall (and a quick Google search), there is a big problem with Miller's experiment: the "environment" that Miller created was nothing like the environment of pre-biotic earth, becaus Miller's "atmosphere" was oxygen free, but geological evidence indicates that free oxygen has always been present on earth.
Also Miller had to create a "trap" to collect the amino acids being formed to protect them from breaking down again. What would the comparable "natural" trap be?
Finally, the mix of both D and L aminos in Miller's soup presents a major problem. Living cells only use L amino acids. D aminos and proteins are toxic.
So it seems to me that what Miller demonstrated is that creating amino acids requires an intelligent mind controlling the process.
------ "Darn floor. Big bite." (Koko the gorilla's best attempt at explaining the experience of an earthquake.)
creationist moron needs spell checker - TRUELY!
The production of amino acids on the early earth is neccessary for spontaneous generation, but amino acids are extremely simple compared to proteins and cellular structures. One would expect amino acids whether the spontaneous generation of life happened or not.
Saying that the existance of amino acids on an early earth proves spontaneous generation is almost like saying the existance of carbon and water on a planet proves the existance of life on that planet. Inconclusive!
David Pesta
B.S. Biochemistry
been run for? I mean, has anyone set up a big tank o' goo, shocked it and shone uv light in it for several years, to see what develops? COuld life actually evolve(theoretically, i know statisticlly, it wont happen) in such a circumstance?
All Troll + "offtopic" mods are meta moderated as "Unfair", because you abused the system.
Of course, Creationists don't take this theory seriously, because why would there be a glass flask on prehistoric Earth in the first place?
So, the chances are actually incalculable. Lottery = your chances in getting picked out the pool may be one in a million, but your chances of picking the right number on the right day and being that one in a million are impossible odds. Then you have the odds of actually claiming your prize and meeting the eligibility/legitimacy of the prize.
;)
Odd. I could swear that there are people who've actually won the lottery... a couple hundred in America, I wager, which puts them at just about 1 in a million.
Statistic impossibilities mean "don't plan on it happening to you," not "it'll never happen to anyone."
Not a single scientist has been able to prove 100% that life DOESN'T exist elsewhere, only propoganda and conjecture.
I guess that leaves us with a fucking possibility then.
yep and all quite neatly explained by Lee Smolin's theory of Cosmological Natural Selection. See his book The Life of the Universe. No god needed here, nor any rampant anthopocentricism, just physics and evolution. And remember kids, evolution evolved out of blind iteration.
I used to have a better sig than this, but I got tired of it
RNA worlds model a higher level of assmbly where amino acids are constructed into RNA. RNA worlds are assumed to also be a necessary (but later) step in the Origin of life. One problem with the approaches used is that historically they used to require lockstep state transitions, but recently Wright and Joyce developed a continuous approach, which allows transitions to occur at overlapping time.
All 21 chemicals can be found in a bucket of Kentucky Fried Chicken...
This space for rent.
Racemic mixtures are not decompsed anything. They are mixtures of "mirror-image" molecules. A completely racemized mixture is one with equal numbers of "left" and "right" members. Presence of both will not prevent you from using one or the other.
Look at you set of hands, one is racemic "left" and the other is racemic "right". You have a completely racemized mixture of hands. This does not deny you use of your left hand.
If amino acid procduction is industrial, usually you get (depending on the process) a mixture of the two racimic (D and L) formations that an amino acid can take. They are mirror images of each other.
Why is this important, well on planet Earth, almost all amino acids involed in life are of type L. (Metorites and non-living processes contribute the majority, if not all, of the D racemes discovered today)
Why only L-amino acids? Today we do not "know" with 100% certainty, but the theory is a living system, for whatever reason, started producing L-amino acids, which unbalanced the ratio. Other living systems (or perhaps the same one) which harvestd these L-amino acids survived and thrived in this L-amino acid rich environment while those that required D-amino acids may have never existed or may have died out due to competition.
When in university physics lab, my partners and I did a sequence of rocketry experiments including thrust curves for the engines, design of a fuselage, wind tunnel testing, and ultimately launch and altitude triangulation.
Our wind tunnel results conducted with a full motor showed decent stability. However, with a spent motor to simulate conditions in the unpowered flight segment, they showed considerable instability in the vessel. It was, however, extremely light (designed to maximize altitude for a given motor, basically it was a nosecone and fins on a motor) and the miniature wind tunnel was another student project which was poorly sealed and, we reasoned (despite our thorough application of duct tape) quite turbulent, so we didn't put too much faith in those observations.
The initial launch was a total disaster. Barely clear of the guide rod, the thing became a tumbling menace, spiraling out of control before burying its nose in the dirt just a few meters from the pad.
A caffiene-filled night later, we had identified the problem. As mentioned, we were designing to tight tolerances to maximize altitude for a fixed engine. We had minimized surface area to minimize drag, keeping center of pressure behind the center of gravity. The only problem was, we designed with a fully-fueled engine, and once the fuel began to burn and exhaust out, the clay nozzle of the engine rapidly became the most massive component, shifting the center of mass rear of the center of pressure. Turns out that wind tunnel was right.
We all got As for the analysis of our failure. After finals, we slapped some oversived fins (designed for center of mass conditions in unpowered flight) on that sucker and got it up about 1/3 mile.
Trouble making decisions? Just flip for it.
I remember hearing the 'odds are so long it must have been design' argument from my 7th Day Adventist uncle and being pretty convinced. Then the lottery came to my state. The odds of winning were insane... you had to pick 6 numbers between 1-50. The published odds were like 1 in 14 million or something like that. No should ever bet on those odds.
But then I started to notice something fascinating... people were winning. In fact, it became big news when more than two weeks went by that no one won. Turns out, a whole bunch of people play the lottery. Enough to make the odds of the lottery being won *by someone* pretty close to 1 to 1.
Now the odds of life developing at random are probably greater than 1 in 14 million. But I invite you to look at the sky on a clear night. Start counting the stars. Then try to comprehend how much time 4 billion years is (I can't). Try to figure out the odds that makes an event *unlikely* to happen given that many players and that much time.
That's a lot more stable environment to allow complex reactions to repeat themselves than one where a few gazillion volts of lightening zap a bowl of soup in a tidal basin that continually dries out and is pounded by waves.
Look! Blue-green algae! ZZZAAAPPP! No it's not.
This is slashdot. Don't expect rational discussion or intelligent commentary. You'd be amazed at how many self-righteous Creationists there are around.
Stick Men
Replies to several different posts (sorry for the lack of attribution): /Ah, but does he mention that his amino acids... /broke down as fast as they were made (in a /carefully customised device, not in the wild), /and were completely racemised at formation? Or /that no evidence of a reducing atmosphere exists?
/Also Miller had to create a "trap" to collect the /amino acids being formed to protect them from /breaking down again. What would the comparable /"natural" trap be?
/As a student of Biological Anthropology, I have /had the oppertunity to take a history of /biological anthropology in which Miller was /mentioned. Interesting guy, but the theory is not /supported any more except by the few staunchest /researchers. In other words, this is pop science. /It survives in text books (like many other /evolutionary inaccuracies that nobody seems to be /willing to update). In truth, the experiment did /not conclude much. In short, the amino acid /theory in reality did not produce very much at /all
Amino acids tend not to break down much. They are exceedingly stable once made. Those that happened to wander back into the electric current might have suffered, but the majority would have stayed safely in solution. The chemical reaction was proceeding in the gas phase; the products were sequestered in the water.
The products are racemic amino acids. Several plausible hypotheses have been put as to how it happened that the L amino acids became predominate: circular dichroism in natural radiation, preferential decompostion of D 14C labeled amino acids, etc.
We don't know all that much about the exact composition of the atmosphere at every time in the earth's history, but the fact that high-energy processes can give amino acids from simple precursors trumps all nit-picking.
The natural trap would be water. High energy events are always happening in the atmosphere (lightning, UV rays, cosmic rays). Lighting blasts convert nitrogen to nitrates. Roughly 10% of the nitrate in soil comes from nitrogen transformed by lightning, and the nitrates are trapped by water. The point to take home from the Miller experiment is that the small, high-energy intermediates formed by these processes can combine to form biologially complex building blocks.
This is just wrong. The conclusion drawn from the results of the experiment was revolutionary. It is of at least on the scale of Wohler's synthesis of urea, a biochemical, from "dead" cyanogen and ammonia.
If Slashdot were chemistry it would look like this:Cadaverine
...could someone tell us if and how the remaining 8 essential amino acids can be formed?
Personally I would trust a link to a respected scientist's site, a citeseer reference, hell, even a New Scientist story or BBC report.
/. comment.
Even a geocities page would give me more confidence than a
that's why i keepy buying lottery. and they told me lottery is tax on people who don't understand math. ha.
If you're going to scream-capitalize words, at least spell them correctly, creationist.
"Semen + sea-people = seaciety"
Actually, I seem to recall that the way that hypotheses operate is by being proven wrong. Empirical evidence can stack up for years in favor of a hypothesis, but a single test that shows it doesn't work under one of the given conditions disproves it.
I will refer you to this site, which has a handy breakdown of the scientific method for you. Note in particular the bit that says "Experiments are useful in disproving hypotheses. Hypotheses cannot be proved."
The God argument is a problem for scientists *precisely* because it's not disprovable. (Note that that does not mean it's true by default, it means that there is no way to test whether or not it is true.)
Why argue about this? The Bible is not a science book the creation story was written the way it was because ancient people who read it nor those that wrote it understood amino-acids.
I'm a Christian, I've moved on from this argument because it doesn't matter how we got here, what matters is that God did it and why and how we are supposed to live now. Doing otherwise puts God in a box and limits him by religion (and that IMHO is wrong).
The Anti-Blog
shouldn't that be Primordial Poste?
Of course, there are also many self-righteous Evolutionists here. And self-righteous religious people, self-righteous non-religious people, Linux bigots, Windows bigots, Mac bigots, bad spelurs, grammar nazis... you get the idea. And the moderators are all on crack. We're all doomed.
Sort of off-topic, but then again, sort of on...
I remember a philosophy class I took my first year of college... The final exam was the professor putting a chair in the middle of the room and then telling us "write in no less than 1,500 words why the chair exists".
Well, I sat there for about an hour not being able to come up with anything reasonable to put down. So, finally I gave up...
I wrote on the paper: "What chair?!?" and handed that in.
I got an A+.
If a pion (n-) collides with a proton in the woods & noone is there to hear it, does lamdba decay into the source pa
To get Methionine and Cysteine, you would have to have a sulfur source, which Miller didn't have in the original experiments.
What did early life think when it crawled out of the primordial soup?
Who pushed me in?????????
Miller had faked his results (ha!), etc.
:D
Grew up in the south?
With the public school system as it is in many places I'm not suprised that such an answer would get you high marks.
We were always told that abiogenesis was impossible and that the Miller experiment failed to show that it was possible to create life from a basic "primordial soup".
I remember it very clearly... It was 10th grade biology. My teacher mentioned the experiment and I remember very vividly that I was so taken aback by what he was saying. It seemed so immensely important and profound, and yet no one else in the class seemed terribly interested. I was simultaneously excited and sadened.
Excited because I'd learned of something so seemingly important, and sadened because no one else seemed to see the importance of it.
That was also the year I saw the first images of atoms, that one where they had written the letters IBM with Xenon atoms. That was another tremendously shocking experience.
Is it just me or does the vast majority of the general population no longer see the importance of pure science? Are we so accustomed to amazing developments and incredible pieces of technology surrounding us all the time that things like these just don't impress us any more?
Seeing atoms SHOULD amazes us. Learning of the building blocks of life being created from scratch in a jar SHOULD boggle our minds. Yet so many people shrug things like this off and don't see the fundamental nature of them.
Ok, now I'm just sadened!
If a pion (n-) collides with a proton in the woods & noone is there to hear it, does lamdba decay into the source pa
You couldn't patent the chemical combination... only the process of making them. But sometimes the presence of chemicals is proof you used such a process. The result is the same.
... to thinking that all life forms must be similar to what we see on our planet.
It all reminds me of a story by Terry Bisson that was part of a series called "Alien/Nation".
Basically, it's a conversation between life-forms that in no way resemble anything we've seen on earth.
Here's the story.
Go here for teh [sic] funny.
For more information on Miller and prebiotic Earth, here is a quotation from an Angew. Chem. review article by Kay Severin called Hot Stones or Cold Soup? New Investigations on the Endogenous Origin of Organic Compounds on Earth (Angew. Chem. Int. Ed 2000, 39, No. 20). It pretty much sums up the Miller reactions, why they're wrong, and what people think now:
... was carried out almost fifty years ago by Stanley L. Miller, at that time a PhD student in the group of Harold Urey in Chicago. Miller was able to show that electric discharges in an atmosphere of methane, ammonia, hydrogen, and water led to the formation of significant amounts of various amino acids. Experiments of this kind were repeated in numerous variants. If reducing gases were employed mixtures of organic compounds of low molecular weight could be detected in many cases. This has led to the popular idea that the primordial ocean resembled a nutritious soup.
"The most famous experiment
"But the possibility that earth once had a reducing atmosphere is questioned. A well known argument against it is the high photolability of methane and ammonia. Because a shielding layer of ozone was missing a high concentration of these gases is believed to be unlikely. Furthermore, several other results point to a neutral atmosphere of CO2 and N2. Given the fact that the atmosphere was based on an unproductive mixture of CO2 and N2 the nutritional value of the primordial ocean drops significantly.
"An alternative scenario has been propagated for several years by [Gunter] Wachterhauser. Instead of a primordial soup he favors hot minerals as the place where organic molecules were initially built as life subsequently emerged. Especially sulfur-containing minerals like pyrite are proposed to have acted as an energy source and catalyst both under the extreme conditions found in hydrothermal or volcanic vents."
Basically, primordial soup syntheses (like Miller's reactions) are out and hot rock syntheses are in. These hot rock procedures have much much much lower yields, but people are slowly figuring out how to build amino acids through them. For instance, people, headed by Wachterhauser, have figured out how to carbon fixate (condense) carbon monoxide and carbon dioxide into organic building blocks for amino acids. For instance, in early 2000, Chen and Bahnemann were able to convert CO2 and water to small organics (acetaldehyde, ethanol, acetic acid) at high pressures and temperatures. Similarly, people have figured out how to take amino acids and convert them into peptides under high temperature and pressure situations.
However, to date no one has been able to actually make an amino acid through these techniques. As a result, the proof that amino acids were delivered by comets or meteorites (true fact, this is not an x-file) and now space dust, becomes much more appealing. Once the building blocks arrived on Earth, these hot rock syntheses could have taken over.
The creation story in the bible takes up the first couple of chapters of the first book. (Biblical chapters are very short!). The rest of the bible is legal code, moral code, and history. Clearly, the main thrust of the bible is not to explain our physical world, but our moral world.
It's not wasting time, I'm educating myself.
Its called "ninhydrin", and it gives a blue color with all primary amines. Therefore, your test is more likely a false positive for a primary amine and not an amino acid.
A much reliable test would be to actually characterise the products by running a collumn on it.
Is the sound of three thousand axes being ground in an enclosed area.
It is a far leap from amino acids to life. I am still baffled by those who think that life just happens. The Earth's atmosphere today is much more hospitable to life but we still do not see amino acids coming together and organizing into complex proteins or anything resembling life. This can't even be done in the laboratory.
It is contrary to the 2nd law of thrmodynamics.
I don't believe in spontaneous generation. The odds of it happening are beyond astronomical.
Give that instructor praise, apples, and as much cash as you can muster up. It is so
refreshing to see an instructor who encourages critical thinking in their student, its not
enough to know that we know something you must also know how we know it, it is the
lack of the latter in our schools that has created a nation in which many people think the
sun revolves around the earth.
-troy
This is slashdot. Don't expect rational discussion or intelligent commentary. You'd be amazed at how many self-righteous Creationists there are around.
Not to mention devout evolutionists.
> You're whining that the odds are too big, but it's guys like Stanley Miller that are trying to figure out exactly how big those odds are.
One of creationists' biggest misunderstanding about science is the idea that scientists believe that stuff like abiogenesis "just happens" at some zillion-to-one odds. In reality, scientists are just like creationists in that when they see something that they intuitively recognize as improbable in a completely random universe, they want to know how the odds were beat. But creationists and scientists immediately part ways at that point, with the creationists immediately jumping to the "goddidit" conclusion, and the scientists examining the phenomenon (like Miller did) to discover how things actually work.
Sheesh, evil *and* a jerk. -- Jade
Evolutionists believe in evolution because that is what the observed evidence demonstrates. It is a matter of fact, not faith. They are not devout.
Get your facts straight.
Stick Men
> I give the SETI people credit for the attempt; but, I don't believe that their project, because of it's limited scope, will bear fruit. They are only looking within the near 50-150 light years or so. Beyond that, the signals are too weak and the time-lag would make communication impossible beyond "Hey, we're over here."
It may also be the case that species that are foolish enough to broadcast their existence to the void have a shorter life expectancy than those that don't, as a direct result of those broadcasts.
Given how well we humans get along here at home, how well should we expect unrelated intelligent species to treat each other?
Sheesh, evil *and* a jerk. -- Jade
Teacher: So, you're going to pass a spark through a mixture including hydrogen and methane?
Me: Well, yes, but there's no oxygen, so it can't burn or explode.
Teacher: I think I'll watch you turn it on from behind this desk.
Ce n'est pas la premiere commentaire! Je fais de la flatuence dans votre direction generale! Votre mere etait une hamster, et votre père aiment puanteurs comme des baies de sureau !
VOUS L'ECHOUEZ!
A Beowulf cluster of those...
Probably will be just a beowulf.
This article amazes me. These people literally assembled a lifeform (or does a virus not count??) from the raw materials.
(-1, Troll) indeed. See you in meta-mod!
I know nothing about this, but what reason do sicentists have to beleive that these amino acids or their compounds exist elsewhere in the universe? I'm always surprised by experiments which purport to prove omnipresence of life based on what we find on earth, which we suspect to have life. Even if we could extrapolate that minerals required to form amino acids exist elsewhere, what about other factors, such as the axial tilt, elliptical orbit, ozone, oxygen, abundant water, meteor belt, etc which combine to form life here? I'm not doubting, I'm just curious.
Nope, a virus does not count. A virus can't replicate itself without commandeering the cellular machinery of a real lifeform (a bacterium, for example. Or a human being. Or something in between.)
A virus is just a strand or few of DNA or RNA in a simple protein wrapper. The fact that the group in the article could assemble one is still a monumental accomplishment, but we're a long way from being able to put together a living creature from scratch. (Cells are really complicated things, with a lot of tiny parts.)
~Idarubicin
Well, depends on how much you want to consider that to be 'raw' materials. They pre-assembled a DNA strand.
Ninhydrin. Cool stuff. Completely colorless but turns bright purple in the presence of amino acids. A great prank was leaving trace amounts on someone's pen or something...
No surprise you got a high mark. Experiments that fail are very important in science, and understanding why they may have failed helps inform further research. The important thing about science is explaining why, not "winning the lottery"
"dope will get you through times of no money better than money will get you through times of no dope"
He's not defunct. His point was that the building blocks of life - complex organic molecules - can be formed from inorganic molecules. And he was right, and still is right.
The actual mechanism might not be what we thought it was then, but that is irrelevant.
Does the fact that gravity may function by means of gravatons invalidate the work of Isaac Newton?
Boobies never hurt anyone. - Sherry Glaser.
He has a page at UCSD. He has managed to synthesize other important biological bricks such as purines, pyrimidines and sugars. He parlayed his initial success into a career of exploring mechanisms for life origins.
> So, the chances are actually incalculable.
This is one of the problems I have with creationists. You assume that, without a diety to guide creation, everything is random, so that the odds become incalculable. The problem is that it isn't random. Only certain chemicals will react with each other, once that reaction occurs subsequent reactions become even more limited. It is entirely possible that within the first pico-seconds, the rules of physics (or maybe the math that defines the rules), made intelligent life inevitable.
> Amino acids, planet size, PRECISE planetary evolution, distance from a sun, atmosphere, OTHER life, moons and magnetic/gravtational forces all contribute to life existing
Only life as you define it, even then, our planetary evolution has not been precise. What does having a moon have to do with anything?
> Not a single scientists has been able to prove 100% that life exists elsewhere, only propoganda and conjecture.
The same can be said for all religons.
between the greater and lesser infinities sleep the dreams undreamt
Well, this is closer to biological engineering from a creative human force. And it wasn't done from raw materials. Here is what the article says,
"Using genetic code as the recipe and carbon-containing chemicals as ingredients, researchers have made infective poliovirus entirely from scratch. This is the first time that a working biological entity has been made using chemistry alone...They put this synthetic virus genome into "cell juice" - a mixture of protein-building molecules and catalysts - and watched the virus assemble itself."
All the mechanisms for virus production were in the test tube. It is funny that the article says that they made the virus " entirely from scratch". It certainly is great research though.
You know, there may still be someone on the planet who hasn't heard this one, but I wouldn't bet on him reading slashdot.
Don't pretend that a well-known anecdote is your own creation. That's just... crass.
--grendel drago
Laws do not persuade just because they threaten. --Seneca
Bullshit.
...from what you believe. If one wants to believe that chance and pure science resulted in what we are today, one can find a way to do so, by believing that the universe's matter spontaneously appeared as proposed by Hawking, and that somehow our earth was precisely as close to the sun as it has to be (slightly either way and we wouldn't be here), and that lightning struck the right soup (despite that these experiments no longer stand up to scrutiny), somehow bringing order from disorder (flying in the face of everything else in our entropically increasing universe) in the perfect, chemically left-handed way, and that given enough time (and people have shown that indeed, we have not had enough time!) mutations combined with competition led to not only improvements but revolutions in life forms leading up to a singular, particularly unique human being. On the other hand, if you believe in a loving universal creator, you will see the hand of a brilliant designer at work in our world. It will make sense to you how animals somehow know what food not to eat, why 'Occam's Razor' doesn't apply leading us to an entirely plant and insect based world, and you won't be suprised that constellations have ancient names whose origin is unknown yet points to Biblical prophecy. As you can probably guess, I fall in this latter category. It's not because the church told me so, and it's certainly not because I don't like science, it's because God told me so. I have also learned that evidence nor arguments will not sway people from one way to the other. As an engineer, this is sad, since I naturally gravitate towards this approach. Though yes, I enjoy reading about how more and more even secular scientists are 'out of ideas' on explaining away God, and reading honest looks by Christians and the same (e.g. The Case for Faith), I don't expect many people to change their beliefs because of it. People will not (and cannot, really) release their core denial of a creator, that is, unless the creator helps them and they let the help in. I know how difficult this is to accept for most people, but all I can say is to give it a shot, stripping away everything non-God apart from it (which leaves you really with the (gasp) Bible...). And then, you may finally see how silly it is to think that electrified chemicals and enough time led to the creation of the singular ball of pure creational brilliance in our universe.
Does it hurt to hear them lying? Was this the only world you had?
...from what you believe.
If one wants to believe that chance and pure science resulted in what we are today, one can find a way to do so, by believing that the universe's matter spontaneously appeared as proposed by Hawking, and that somehow our earth was precisely as close to the sun as it has to be (slightly either way and we wouldn't be here), and that lightning struck the right soup (despite that these experiments no longer stand up to scrutiny), somehow bringing order from disorder (flying in the face of everything else in our entropically increasing universe) in the perfect, chemically left-handed way, and that given enough time (and people have shown that indeed, we have not had enough time!) mutations combined with competition led to not only improvements but revolutions in life forms leading up to a singular, particularly unique human being.
On the other hand, if you believe in a loving universal creator, you will see the hand of a brilliant designer at work in our world. It will make sense to you how animals somehow know what food not to eat, why 'Occam's Razor' doesn't apply leading us to an entirely plant and insect based world, and you won't be suprised that constellations have ancient names whose origin is unknown yet points to Biblical prophecy. As you can probably guess, I fall in this latter category. It's not because the church told me so, and it's certainly not because I don't like science, it's because God told me so.
I have also learned that evidence nor arguments will not sway people from one way to the other. As an engineer, this is sad, since I naturally gravitate towards this approach. Though yes, I enjoy reading about how more and more even secular scientists are 'out of ideas' on explaining away God, and reading honest looks by Christians and the same (e.g. The Case for Faith), I don't expect many people to change their beliefs because of it. People will not (and cannot, really) release their core denial of a creator, that is, unless the creator helps them and they let the help in. Curious? Ask God for help, he won't turn you down.
I know how difficult this is to accept for most people, but all I can say is to give it a shot, stripping away everything non-God apart from it (which leaves you really with the <gasp> Bible...). And then, you may finally see how silly it is to think that electrified chemicals and enough time led to the creation of the singular ball of pure creational brilliance in our universe.
Does it hurt to hear them lying? Was this the only world you had?
I appreciate all the comments here that were insightful and read/responded to my post for comprehension.
I do have one question? If you disagree with me and I was on topic and you respond more than ANY OTHER post posted on Slashdot today, does that not make the post interesting.
I also wish people would stop making this forum a FAR LEFT ANTI CHRISTIAN forum. In no way affiliated myself with religion. Read it again and you will see. (I am a god fearing Christian though) People here mod religious/conservative posts like the KKK would mod Martin Luther King. (If he posted, had something insightful to say, a racist would still mod him down.) In order to debate creation and god and politics you have to know the other side, I post that other side.
Hmmmm so how can you be so sure you are praying to the right god? I mean maybe the Aztec god Coatlique created the world... or was it the Egyption god of creation, Ptah, or how about Gaulish, the Celtic god of creation. Maybe they are all wrong and the earth is actually suspended on the back of a turtle.
Remember seamonkeys? With a little "tweaking" I am sure they could package this 'creation in a flask' and sell it. For the low low price of $29.95, it could bring out the Omnipotent Overlord in everyone!
All you need is a positive non-zero probablity for something to eventually happen. We have no idea how amny times life almost formed and then died before it finally succeeded.
Not quite. There are limits to chance. There is a number which represents the number of electrons in the universe. If something has odds of 1 in that number, it is considered impossible.
The 'monkeys on typewriters ending up with war and peace' flies in the face of reason, IMHO, and yet it is a crutch and fundamental pillar of evolutionary theory, attractive because one can always simply require the disbeliever to roll the dice a trillion more times or so.
For those who think I'm rationalizing equally with my limited 100 year lifespan perspective, consider this: they have never discovered fossilized remains of an inter-species mutation; e.g., a creature evolutionarily between A and B. With all the dice rolling and obvious failures along the way, one would expect to find a whole lot of these, no?
And, the earth has not had an infinite amount of time to roll the dice. It is of finite age. Recent work shows the earth as 5 billion years old, not counting for the time it required to cool. Fossil evidence shows life emerging 400 million years ago. This is not enough time to go from scratch to our planet's situation today. Even if you took all the carbon in the universe, put it on the earth, allowed it to react at the most rapid rate possible AND left it for a billion years, the odds of ending up with one functional protein are 1 in 10exp60.
Does it hurt to hear them lying? Was this the only world you had?
This is one of the problems with people who have nothing to say. You assume that, everything you have to say is interesting, so you like to blurt out meaningless lines and hand out mod points like they were hickory switches. The problem is that nobody cares about your posts. Only certain people get a rise out of it, once they get a rise, they think they are joining some anti right mantra here at Slashdot. It is entirly possible that within the first few posts that you disagree and you make an insightful counterpoint.
That was what your post says to a newcomer to this thread. If I had points I'd mod the parent with all 5 Interesting.!
I replicated this experiment as a High School Chemistry project twice, once in 1959 and again the next year in 1960 (Van Horn High, KC Mo). I used an inverted flask for the gasses, heated a small test tube placed through the stopper in the bottom of the flask electrically for water vapor, and provided "lightning" in the form of a sparking gap within the flask (neon sign xformer, through a cap). Ran it a week both times. Both times so many amino acids were produced that the fluid that collected looked like thick strong tea. It blew away the ninhydrin test! I kept both of these fluids for years, actually almost 25 years, before discarding them and they were STILL a thick primordial soup after that length of time.
Don't believe me? Try it yourself!
Moderators, please pull your heads out of your asses for one minute and think about this... me: "You can integrate by parts, buy you can't solve '2 + 2 = ?', is this correct?" Saint Aardvark: "Yep."
Amino acids and other organic compounds are found in some of the instellar dust clouds around the galaxy. Astronomers think these are formed by the interactions of C-N-O-H atoms over eons of time, but other explanations are possibily. NASA scientists have successfully done a space-analogue of the mIller experiment. Life soup is everywhere!
WITH!
BABELFISH!
For all you slashdotters out there who don't speak Freedom, or are too lazy to look it up on babelfish yourself, I'll be your translator today. First, the grandparent.Babelfish spits this out:It seems to be a standard "YOU FAIL IT" gag based off of the mock-french failed first post attempt. All geeks should recognize this as a snippet of the French Knight's monologue in "Monty Python and the Holy Grail".
Now to the parent.Babelfish gives us:Notice the hilarious mangled phrases like "Whore of shit or am I?" and "Eh well". I can't tell whether the parent thought that "to make flatulance" was more or less coarse than the phrases selected!
And that's how you play...
FUN!
WITH!
BABELFISH!
You've been a wonderful audience, thank you, good night.
Why bother taking the probe out at all?
Surely it'd be easier and more elegant to design a reaction vessel with probes/sampling ports built in. You could then seal the apparatus at the start of the experiment an have a fair degree of confidence that it would stay sealed until you ended the experiment.
If you want a simple experiment into keeping things sterile and uncontaminated, google for Pasteur's experiments with swan-necked flasks. These were originally designed to disprove the theory that bacteria and moulds (and indeed worms, beetles, etc) would spontaneously form and begin multiplying in dead organic matter. Very simple, very elegant, and proves the point very nicely.
RUN!!! Don't walk, to the nearest exit.
Da Blog
>>It is entirely possible that within the first pico-seconds, the rules of physics (or maybe the math that defines the rules), made intelligent life inevitable.
Sure, but that's not science. Many things are possible that have not happened. What if perhaps the Creator of the rules and the pico-seconds would prefer to be credited with the creation?
yes.
-pyrrho
>It's sure starting to look like Syria is queued up for the next liberation.
and now, if someone spills beer on you in a bar you say, "Hey buddy, let's take this outside where I can drop a little liberation on your ass!"
-pyrrho
There's a very good reason it would not work for you, one that is why Miller's experiment is not very useful. Hard UV (which you probably didn't have due to HS safety concerns, and which would have been blocked by the glass most likely anyway) would have dissociated the NH3 fairly rapidly.
That leads to a basic problem with the Miller-Urey experiment: their assumption was no free oxygen (they assumed a reducing, not an oxidizing, atmosphere). Free oxygen would completely mess up the reactions, so they excluded it from the experiment.
But without O2, there would be no O3 (aka ozone) in the upper atmosphere. That would mean that lots of hard UV would be coming into the lower atmosphere. That hard UV would dissociate any NH3 around, and without the ammonia, the experimental conditions would not have a good source of nitrogen, as N2 is so tightly coupled that it's close to inert under the conditions they were using.
So the experiment, while interesting, was pretty useless. With O2, it wouldn't work. Without O2, there would be no NH3, and it wouldn't work. Joseph Heller wrote a book about that basic concept once, called "Catch-22".
Got Wisdom?
I tried this experiment in hich school too. In 9th grade when I was going to a private school that actually encouraged students to do things. As for no being able to make a spark, it's easy. I used some wire, an ignition coil from a car, a couple lantern batteries, a reed switch from a pinball machine, and a matchstick glued to the spinning wheel of an old walkman. I also had no idea how to work with gasses so instead of methane I used ethanol, Everclear specifically [190 proof]. As for what came out at the end, I have no idea. Thin layer chromotography isn't easy to do in your garage.
This is not necessarily so.
1. For fotolysis of ammonia, one needs a hellotof UV - very strong source. Not likely to happen.
2. Ozone is not the only UV absorber known to man - the most common kind is complex organic molecules. We do not have much of complex organic compounds in air nowadays (except for Mexico City, Peking, LA and Fresno valley) but those aerosols or volatiles could have shielded UV in the early days of Earth.
I doubt that we will ever figure out - and I suspect that even if we did figure out we couldn't do much about it
Whether a virus is life or not is kind of splitting hairs.
By the definition of a parasite, it certainly fits.
Whether we should think of them as life or not should probably depend on whether they are the result of some kind of true life, like a simple bacteria, that evolved downward, or they are the result of some random chemical reaction that then began picking up steam from evolution.
"Has [being a kidnapped teenage girl, raped repeatedly for months] changed you?" - Katie Couric to Elizabeth Smart
If there were aerosols or volatile organics, they would also interfere with the experiment in significant ways, particularly if they were of a concentration sufficient to block UV.
Photolysis of NH3, over the time periods considered, is sufficiently rapid with unshielded sunlight (i.e., ozone layer-free sunlight) that it would render the experiment moot.
Got Wisdom?
Thank you for so clearly and concisively demonstrating the great heresy that is literalistic creationism. Your faith is so weak that you would view the demonstration of an Earth older than what one small branch of literaloid christianity's interpretation of what the Bible says is the age of the Earth that you would renounce your, well, what passes for your "faith." You would take this spiritually and intellectually bankrupt branch's "inerant" interpretation of the Bible (but only when convenient, no no it's okay to mix fabrics of wool and flax, no rabbits don't chew their cud, eat pork it's good for you, Revelations is actually about the end of the world not pressures facing the Roman-era Church, a hot fish in the navel really means a hot fish in the navel, isn't that sensual) or more accurately a fallible man named Ussher's declaration of a ~6000 year old Earth over the assumption that a) God is wise, b) God's universe is orderly and follows the Laws that He Himself laid down in the Beginning, c) God is not some petty trickster decieving those who search for understanding of His great Creation. Instead you have thrown your lot in with the lying creationists who decided that pride is a virtue, deceit is moral, and try to hide His wonderous Creation from those who seek it out. I pray that you get down on your knees and beg forgiveness for your sins from the Almighty Lord your God and renounce your heresy, Pharisee.
Miller had the guts to actually go out and try it to see what happened. That's actual hard science rather than just pontification. You've gotta salute the man for that.
However, he did that original experiment - and many followup experiments - to prove a specific ideological point. Not only did he fail to prove the point<1>, he's steadily establishing with ever greater precision and completeness that even under the most optimistic of assumptions and with the most carefully crafted of experimental rigs, life does not form spontaneously, and nor do any significant precursors to it. It would be significant if he could even establish a substantially homochiral collection of organic molecules using only bulk chemicals and believable conditions, but his work has steadfastly shown that to not be at all achievable. Rationally, Miller now needs to let go of his ideology, and won't.
<1> the original sense of the word "prove" meant "test to destruction", and in that sense Miller did "prove" his point.
Got time? Spend some of it coding or testing
Porosities in clay have been proposed (and again later in the theoretical process as prosthetic "cell walls"), but they don't close the gap to any significant extent.
Aside from the reducing atmosphere, and racemisation, there's also the concentration of chemicals needed and the intrusion of pollutants. Anything like UV radiation or lightning would be pretty disruptive as well. The list goes on.
Got time? Spend some of it coding or testing
Just to make sure I understood you: in order to get self-replicators we need to conserve amino acids as they form. How do we do this? Why, of course! We use self-replicators.
What can I say? "D'oh" seems to cover it all. (-:
Got time? Spend some of it coding or testing
True.
Many basic blocks are still missing, and you can't do much with a pile of blocks anyway.
Most people think in terms of building a Lego lifeform, now that the blocks are available, but even building a "simple" lifeform from these bricks is somewhat akin to building a Gibraltar Bridge out of Lego (with all of the long ones missing and half of the existing pieces having the dots and dents the wrong way out, just to add insult to injury). Many others think that if you build DNA, you build life, but this is kind of like thinking that if you can just fab a raw Athlon wafer (by accident, out of sand) you've got a super-computing cluster on your hands. On top of this, life is dynamic.
A big jolt of required perspective is almost always absent when describing putative "building blocks of life". It would be fairer to say that Miller has discovered how to put some of the dimples on building blocks naturally, or perhaps that he's shown how some of the plastics of which those bluidling blocks are made could form under natural conditions.
Got time? Spend some of it coding or testing
Your analogy is broken, or possibly just incomplete. Think of using ordinary scissors with your left hand, to get some idea. In nature, a wrong-handed molecule can, by binding incorrectly, bollox up an otherwise useful organic molecule. It is essentially operating as a poison. For a relatively harmless example, invertase binds to sites normally reserved for substances like sucrose. This provides exactly the same taste as sucrose, but the resulting combination will not digest. Harmless examples are relatively rare.
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Beleiving that the Bible isn't scientific and factual ... then you are NOT a Christian. The Bible explains DETAILED health and nutritional information (to avoid sickness, disease, and even social otrasizing) All of which to this day are factual. There are multiple evidences of a great flood, there are evidences of a star/astronomical phenomenon about the time of Jesus' birth. And we know today that virgin births ARE possible. Explain specifically what isn't scientific in the Bible to YOU as a Christian ...
The Bible was written for ancient people to understand in "current" times true, but written in such a way that it was timeless.
It is contrary to the 2nd law of thrmodynamics. This has to win the award as the single stupidest argument against evolution. The second law merely says that it takes energy to create order. Do we have energy? Hellooo. Look up in the sky. Do you see that bright thing up there?
You argue that time did wonders, I argue that the LORD God did.
So this distills down to: you (and evolutionists in general) believe life was created by your god, which is time. I (and young-earth Bible Believers in general) believe in the LORD God who created your god (time) and space and matter and physical laws and life.
As Dave Moore puts it: "I'd rather believe in a big God and have small problems that believe in a small god and have big problems".
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Said gurus couldn't even tell the difference between Darwin and Hitler when pressed to do so by one of their opponents, why trust them for more subtle reasoning? (-:
But perhaps more important, throw Apollos, the baloney detector at any one of their pages and see what happens. Apollos is a good deal more specific and exemplified than Carl's more, er, primordial detector. G'wan, print it out and go do a few pages, you know you want to!
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Cop out.
If it doesn't follow, you need to specify at least one more alternative.
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In principle. In practice they gloss over an enormous range of inconvenient facts, pander to the personal biasses of the experimenters, and sneak in teleology at every opportunity. In short, they implicity appeal to magic as well, the only serious difference being that thier proponents are not being as honest (starting with themselves) about it.
Meanwhile, the attitude "they invoke magic, so they're not useful" is at best a bloody silly one. Materialist scientists and engineers regularly deal with factors which they don't understand or can't accurately measure, and these investigators don't throw their hands up in despair (mock despair, in your case, since if you suck people in with that attitude, it saves you having to confront those inconvenient facts), they simply apply standard error mesaurement techniques.
Creationism doesn't consist of "goddunnit, amen" any more than your Materialism consists of "time-and-chance dunnit, amen". It consists of doing perfectly ordinary science, taking as axiomatic the scientific parameters outlined in various parts of the Bible instead of taking as axiomatic the holy canticles of Materialism.
Many if not most of the scientists who defined and laid the foundations of modern, western science were Creationists, and several of the leaders in their fields today are Creationists. Serious business. You don't have to agree that Creationism is the best approach to science, but please don't be daft enough to rubbish it so childishly.
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This has been addressed elsewhere in this /. story and /. already has sufficient dupes, so I won't address it again.
First, let's make sure that we're reading from the same page: you're asking me to compare my brand of Christianity with other religions, which you call "fairy tales". Since Materialism is as much a religious PoV as Buddhism or Jainism, not only is it a "fairy tale" but I'm also going to include that in the comparison. Also, nobody was there with a video camera, so all evidence is going to be more or less indirect. But more on that point later.
On the question of origins, there are four basic approaches (modulo some mind-bending fringe philosophies which make The Matrix look simple and tame):
While the steady-state and cyclic camps within Materialism do represent perennialism, I'm going to guess that you don't suport them, and not bother to address them (other than to say that there are many indicators which should be showing up if the universe truly were that old, and they aren't, and that some Materialist scientists are ruling out the cyclic theories).
Indeterminatism is by its nature not addressable. This simply leaves many religions out of the debate, which IMESHO is a valuable distinguishing point that disqualifies those religions due to lack of necessary authority. It should be noted that "I know we're here and I can't see any evidence of God but think evolution is a blind alley so I don't know how we got here but Creationism ain't it" perspective is a dilute form of indeterminatism. A stronger form of my invented term would be "cop out".
Gradualism is easy to speak against in many ways, but I'll keep it brief because this is not the interesting section.
One simple example: the continents. These would wear down absolutely flat within about 10 million years, leaving us a few kilometers underwater (see, the dolphins do win in the end!); if you propose to make up the difference with orogeny, first off there ain't nearly enough of it to make a difference, and second off you also need to explain why the contients, having been completely recycled at least 400 times since the formation of Earth, aren't almost entirely homogeneous instead of being, as they are, possessed of a significant amount of internal structure. AFAIK there is no suitable sorting mechanism or anything resembling a candidate. The homogeneity, by the way, is a de novo piece of reasoning; if it appears anywhere else it's a coincidence.
Another by-the-way, examples of large-scale rapid erosion like the Grand Canyon or Washington Badlands don't need to happen very often throughout history to provide a drastic shortening of that ten gigayears, and even given that timescale we should see evidence of a lot more of these features than we do, probably a handful for every hypothetical ice age.
Catastrophism splits into two camps, naturalistic (a la Velikovsky) and supernaturalisti
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