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A Mouse With Two Mothers

jabberjaw writes "Both the BBC and Nature are reporting that scientists at Tokyo University of Agriculture have used two sets of chromosomes belonging to a female mouse to create what are essentially fatherless mice. The process by which this was accomplished (parthenogenesis) does not naturally occur in mammals. The mouse used lacked a gene known as H19 which in turn activated the Igf2 which allowed this process to occur."

19 of 413 comments (clear)

  1. Good News, Really by mfh · · Score: 5, Interesting

    All jokes aside (as I am sure many "two daddy trailerpark" jokes are immanent) but this is indeed quite an advancement in biotech, because we may see future developments arrive in the development of cloning endangered species back from the brink of extinction; now species threatened from a lack of suitable mates, could be quite possibly saved, with the proper funding. The hard part would be digging deeper gene pools, enabling a true future for endangered species (although, I guess that's next week on /., right CmdrTaco?). Also, I wonder if it's possible to grow offspring with only two male subjects.

    --
    The dangers of knowledge trigger emotional distress in human beings.
  2. Parthenogenesis by aacool · · Score: 5, Interesting
    This terms comes from the Greek for virgin birth (;))Natural parthenogenesis has been observed in many lower animals (it is characteristic of the rotifers), especially insects, e.g., the aphid

    The phenomenon of parthenogenesis was discovered in the 18th cent. by Charles Bonnet. In 1900, Jacques Loeb accomplished the first clear case of artificial parthenogenesis when he pricked unfertilized frog eggs with a needle and found that in some cases normal embryonic development ensued

    Artificial parthenogenesis has since been achieved in almost all major groups of animals, although it usually results in incomplete and abnormal development

    The phenomenon is rarer among plants (where it is called parthenocarpy) than among animals

    1. Re:Parthenogenesis by SmackCrackandPot · · Score: 2, Interesting

      It's known to happen in Snakes too. The general theory is that if a female is approaching the end of her reproductive stage, and she can't find a mate, it's more beneficial to the species for her to clone her own offspring, than to not have any offspring at all.

  3. rabbits by zogger · · Score: 2, Interesting

    seems to me this has occurred in rabbits already. Any biologists here correct me if I am wrong. I also think that pregnant rabbits, in some instances, when highly stressed, will literally reabsorb their foetuses.

  4. Moral Discussion by millahtime · · Score: 2, Interesting

    Now, we will be running into a Moral debate over wether this is right or not. There will be homosexual couples pushing for this with people. If it gets to that then they will push for marriage saying they can have families. This could really open up a huge "can of worms" so to speak

    1. Re:Moral Discussion by Tiram · · Score: 2, Interesting

      Gay and lesbian couples can already have families. You don't need to be able to breed for that. And having children is hardly a reason to marry anymore.

      I have no doubt quite a few arch-conservatives will freaked out over this, but really ...

      --
      The knuckles, the horrible knuckles!
      (I'm a girl, you know)
    2. Re:Moral Discussion by faaaz · · Score: 2, Interesting

      What's the problem? What can of worms? Homosexual couples can have babies, great! Is there a reason denying homosexuals that if the technology exists (and they're willing to pay for it)?

      --
      we come in peace / shoot to kill
  5. Also in The Independent by mostaphalles · · Score: 3, Interesting


    Story in The Independent is also a good read.

  6. Re:Baby Jesus by Hektor_Troy · · Score: 5, Interesting

    Well, if you believe that baby Jesus was born of a virgin, then you quite likely also believe that he is/was the son of God - divine intervention.

    Divine intervention is not natural.

    Hence baby Jesus is not proof that it does occur naturally.

    If it did occur naturally, baby Jesus' birth would not be a miracle, which would tend to discredit the claim he is the son of God.

    --
    We do not live in the 21st century. We live in the 20 second century.
  7. Not only does this help remove the need for men... by jamieswith · · Score: 5, Interesting

    But I would have thought that it also removed the possibility of men being produced by this method... I'm not a biology nerd, so I might be completely wrong, but I just can't see where the 'Y' chromasome would come from in order to be able to make a boy!

  8. Lesbian society by 0x0d0a · · Score: 3, Interesting

    So now it's actually feasible for a purely lesbian society to exist and reproduce?

    This should pose some interesting questions for the Christian right's arguments against homosexuality based on infeasiblity of universalization in nature.

  9. Re:Baby Jesus by Perdition · · Score: 5, Interesting

    Some called Tony Hawk doing the 900 a miracle.

    But then again, Tony's 900, as spectacular as it was, didn't fit over 100 pieces of specific predictive prophecy from several hundreds of years of writing, most several hundreds of years prior to the event. And, Tony's 900 didn't quite heal hundreds or feed thousands and deliver moral teachings or resurrect after a decent Roman crucifixion.
    But then again, there are those who think that the sun rising every morning is the result of an image broadcast into their brain by evil goverrnment agents while their bodies are actually asleep on the slab in the lab. They'll say that Tony's 900 will have sufficient artificial prophecy written about it in the near future to make it seem as if it was a predicted event, and they'll say that's it's just a matter of time before there's a Church of the Tony Hawk 900.
    You know, some people believe some whacky things.

    --
    Windows XP SP2 told me to install third-party software that prevents viruses and protects stability... I chose Ubuntu
  10. Re:Two daddies? by Walkiry · · Score: 3, Interesting

    > Doubt it. The Y chromosome is a mutation of the X chromosome and contains much less information.

    Well, that's why you want to use two parents, each carries an X chromosome. I'd guess it'd involve the use of Cyst Progenitor Cells and an Artificial Womb.

    > this research and my time machine seem about equally incomplete

    That's what Ebay is for ;)

    --
    ---- Take the Space Quiz!
  11. Re:Two daddies? by Dolda2000 · · Score: 2, Interesting

    The greatest problem might be that you need an egg cell, though. While you can take an egg cell from a female specimen, it won't help species or human situations when there are no females available.

  12. On Gay Marriage (Re:Lesbian society) by mi · · Score: 4, Interesting

    [Hey, I'm not starting an off-topic thread, I'm merely continuing it :-)]

    Not only are the usual methods of getting children -- "unpleasant sex" and adoption, but this method will also be available to (at least) some homosexual couples.

    The "Christian Right" (not just Christian, and not just "right") are correct in saying, it diminishes the traditional concept of marriage. However, IMHO, the concept is long diminished through other, perfectly heterosexual means. And it is not anyone's fault in particular. The economies have changed. A single parent can raise a child or two (even without government help). Having a good partner in life is not as important to survive as it used to be.

    The "sanctity of marriage" is important for the Society only because it leads to more (and better) children. That's why the State affords special protections and privileges to married (as opposed to co-habitating) couples -- in inheritance, in not testifying against each other, etc.

    Yet children tend to grow up better having two parents. There are no statistics that show, children in homosexual couples grow better or worse off.

    Here is my proposal to the conundrum of gay marriage. Change all laws, that apply to "married couples," to apply to "any pair of people involved in raising children" (the exact formula should be phrased better, of course, it has to mention mutual devotion and loyalty -- borrow from the classic definition of marriage).

    The actual acts of marriage should stop being administered by the State (both directly through mayors and through licensing). People, who wish to publicly swear their mutual love, respect, and devotion are still very welcome to do that (banning people of same sex from such expressions is directly against the 1st Amendment) in places of their choosing (including government buildings even), but it should not be the State's business.

    The State's business only begins when a couple gives birth to (regardless of the conception method) or adopts a child -- that's when it qualifies for the privileges now afforded to the married only.

    This way, the Society will reward exactly those it should want to, regardless of their sexual orientation, which is not, regretfully, a voluntary choice, it seems.

    --
    In Soviet Washington the swamp drains you.
  13. They're working on artificial egg cells. by Moderation+abuser · · Score: 4, Interesting


    http://www.scienceblog.com/community/older/2003/ E/ 20032622.html

    And on artificial wombs:

    http://observer.guardian.co.uk/international/sto ry /0,6903,648024,00.html

    So in 20 years or so, neither men nor women will be required for reproduction.

    --
    Government of the people, by corporate executives, for corporate profits.
  14. Re:Two daddies? by alexq · · Score: 2, Interesting
    I don't know enough about genetics to fully disprove your assertion here, but I _do_ know that genetics are more about how the genes interact with each other than the individual pieces of information - the lack of one genome can cause another to act completely differently.

    Given that, I don't think you can simplistically say that one _or_ the other has more information - just different. Two identical genomes, in different places, can perform very different functions.

  15. Re:Two daddies? by pgolik · · Score: 3, Interesting

    The process that inacivates one copy of X in females is, however, random, so in some cells one copy is inactive, while in other cells it's the other that gets inactivated. So, in females some cells express the maternal X chromosme, while the others express the paternal one. If they are different with respect to a hereditary trait you get interesting results. That's how you get Calico cats (always female), or how you can detect muscle enzyme variation in some asymptomatic female carriers of Duchenne Muscular Dystrophy.

  16. Re:Baby Jesus by Jennifer+E.+Elaan · · Score: 2, Interesting
    Actually, such slaughter is REPEATEDLY condoned in the Bible.

    Here is a particularly nasty quote:

    Suppose you hear in one of the towns the LORD your God is giving you that some worthless rabble among you have led their fellow citizens astray by encouraging them to worship foreign gods. In such cases, you must examine the facts carefully. If you find it is true and can prove that such a detestable act has occurred among you, you must attack that town and completely destroy all its inhabitants, as well as all the livestock. Then you must pile all the plunder in the middle of the street and burn it. Put the entire town to the torch as a burnt offering to the LORD your God. That town must remain a ruin forever; it may never be rebuilt. Keep none of the plunder that has been set apart for destruction. Then the LORD will turn from his fierce anger and be merciful to you. He will have compassion on you and make you a great nation, just as he solemnly promised your ancestors. "The LORD your God will be merciful only if you obey him and keep all the commands I am giving you today, doing what is pleasing to him." (Deuteronomy 13:13-19 NLT)