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Grow Your Own Replacement Bones

Tim writes "New Scientist reports on a German man who had a complete jaw transplant, after having his cancerous jawbone removed nine years ago. The twist? This jawbone was grown on his shoulder, using a titanium mold, bone marrow, and recombinant bone morphogenic protein." There's also a BBC story.

19 of 331 comments (clear)

  1. Re:Great. by garcia · · Score: 5, Informative

    Umm, this really isn't for people with your typical broken bone. This is for people that need a bone replacement.

    It only took seven weeks to grow the replacement jaw-piece and then only four more weeks until it was successfully grown into place.

    For some reason I was under the impression that they had grown him an entire new jaw but that was obviously not the case as they only grew him a piece of his jawbone back. He still has no teeth and the doctors claim he can get a set next year.

    Wow.

  2. Re:remove the titanium? by Anonymous Coward · · Score: 1, Informative

    If i got it right, the cage was only there to form the bone in the muscle. It was not implanted to the chin.

  3. Re:Hurray for Stem Cells Research by plover · · Score: 5, Informative
    As much as I don't like Bush and the Republican party, and think their embryonic stem cell restrictions are the penultimate in luddite stupidity, you should reread the article. This jawbone was grown from his own bone marrow stem cells, and did not require embryonic stem cells. No Bushwhacking would be involved.

    Besides, this was done in Germany. Even if the Theocratic States of America succeed in shutting down all medical progress, they're happy to outsource this sort of thing. Need a new kidney? Fly to Germany, they'll be happy to grow you a new one.

    --
    John
  4. Re:Hurray for Stem Cells Research by Richthofen80 · · Score: 1, Informative

    Bush wants to ban Federal Funding from Stem Cell Research. This seems to be privately funded.

    Stem Cell Research is not illegal. Still.

    --
    Reason, free market capitalism, and individualism
  5. Re:Hurray for Stem Cells Research by jwriney · · Score: 4, Informative

    Don't believe the FUD. Bush is not against stem cell research. He has prevented such research that involves the destruction of human embryos from receiving federal funding. Research involving stem cells from adults, animals, and cord blood, which are all highly promising, is federally funded and ongoing.

    --riney

  6. CT scan shows new jaw in place by beetle496 · · Score: 2, Informative
    --
    I paid the going retail price for a Windows screen reader and got a free Unix computer!
  7. Re:joking aside, by clarus · · Score: 1, Informative

    I'm still anxiousially awaiting the "replacable knee" I think if you can grow the tendons and bones for knees, you could even have a comercial product. Everyone has bad knees and are looking for an upgrade?

    any investors?

    --clarus

  8. Not a perfect example by Titanium+Angel · · Score: 3, Informative

    I agree completely that stem cell research must not be restricted, the potential benefits are simply ming-boggling. But the Associated Press article I read earlier today which covers this same story, however, states that "it's not clear any major scientific ground has been broken, and tests may not be able to show whether the new bone came from stem cells, rather than from the growth factor alone." So in this case stem cells might not have anything to do with the results. That article is pretty detailed as well.

  9. More pictures here by hemabe · · Score: 4, Informative

    If you want to see more pictures, you can find them here.

  10. Re:remove the titanium? by Skjellifetti · · Score: 2, Informative

    I've got a titanium rod and two set of pins in my lower leg. When the surgeon put them in, he told me one or more of the parts may eventually have to be removed. These things can shift in slow and subtle but painful ways as bone and muscles re-grow and become stronger. A friend of mine had to have her pins removed when they started to puah their way out through her skin several years after her broken ankle.

  11. Another Article by Karma+Farmer · · Score: 4, Informative
    Another story, with pictures.

    A quote in that story, from Paul Brown, head of the Center for Tissue Regeneration Science at University College in London:
    Just making the gross tissue shape right isn't really the problem, it's what the shape of the tissue is at the microscopic and ultramicroscopic level. That's the architecture which is so tricky and which is what gives function.


  12. Re:Hurray for Stem Cells Research by raider_red · · Score: 2, Informative

    This was done with Adult stem cells, which are not covered under the federal restrictions, and can be researched in the United States.

    --
    It's good to use your head, but not as a battering ram.
  13. Re:The underlying bone... by symbolic · · Score: 2, Informative

    ...is every bit as important, since advanced pariodontal problems often result from the loss of bone necessary to hold the teeth in place.

  14. Re:Hurray for Stem Cells Research by ImTwoSlick · · Score: 3, Informative
    Why is Bush and his administration against stem cell research again ???

    A common misconception here on /. is that Bush is against stem cell research. The fact is that he's not. He is against stem cell harvesting from aborted fetuses. The law he signed bans only federal funding for stem cell research that uses fetus stem cells. This does not prevent private research in this area at all. In fact, there are now ways to harvest stem cells from adults, and thus doesn't have the same moral complications as the previous method.

  15. Re:A perfect example by ViolentGreen · · Score: 2, Informative
    Apparently, not everyone believes the stem cells played a role. If you look at this article here at cnn.com there is the following quote.
    Paul Brown, head of the Center for Tissue Regeneration Science at University College in London, said it's not clear any major scientific ground has been broken, and tests may not be able to show whether the new bone came from stem cells, rather than from the growth factor alone.

    The operation put established techniques together, resembling a well-known experiment in which University of Massachusetts scientists grew a human ear using a mold on the back of a mouse in 1995, he said.

    "If you put loads of blocks of bone mineral into a hole and you induce cellular activity by putting in growth factors, it's a standard approach that people have used to induce the body's own response,'' said Brown, who was not connected with the study. "Clearly some of them are going to work and it sounds like for this patient, this has worked.''

    --
    Not everything is analogous to cars. Car analogies rarely work.
  16. Re:will religious fanatics go nuts over this? by gregarican · · Score: 2, Informative

    Probably not, since they are talking about the stem cells extracted from living adults, not aborted or lab-grown embryos. There is a difference. Bush's administration has funded non-embryonic stem cell research for awhile now.

  17. Actually... by GreenCrackBaby · · Score: 4, Informative
    Except that Bush is against fetal stem cell research. This kind of stem cell research is supported by Bush. This case actually helps Bush's argument.


    Actually, since this all happened in Germany, and not in the US, I think it is a pretty good case against Bush's stem cell "policy" (more like religious idiocy, imho).

    My wife finished her undergrad genetics degree (at a Canadian university) a couple of years ago, and even then she noticed an increase in the number of people from the US coming up for grad studies, since the type of work they needed to do with stem cells just wasn't possible in the US.

    Stem cell research is going to happen, with or without Bush. The only variable is the country in which it is going to happen, and right now it ain't the US.

    --

    "The market alone cannot provide sufficient constraints on corporation's penchant to cause harm." -- Joel Bakan
  18. Re:I am having something similar by BCW2 · · Score: 3, Informative

    I had fusion done in my neck, C5, C6, C7, in 1998. The Doc went in through the front with a scope, removed the 2 ruptured disks. Then put bone plugs from the donor bank in and screwed a titanium plate to the front. Five weeks later I was back at work as a mechanic. I worked on lighter stuff as much as possible but was up to full strength in six months. No problems since.
    Good Luck.

    --
    Professional Politicians are not the solution, they ARE the problem.
  19. Siegfried Roy's boner by peter303 · · Score: 2, Informative

    When Roy Horn was mauled by the lion, they removed a big piece of his skull to prevent brain swelling. Then they kept the skull fragment in his abdomen a couple weeks until the brain was OK. Sounds a bit creepy to move bone around like that, but its the most reliable way to keep the bone alive.