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Global DNA Project to Study Human Ancestry

Steve writes "The National Geographic Society and IBM are teaming up to map the history of human migration using DNA. The Genographic Project aims to collect 100,000 genetic samples which will be used trace the movements of humans out of Africa and around the globe. While the most useful samples will come from indiginous populations, members of the general public will be able to mail in their own DNA on special cheek swabs."

30 of 325 comments (clear)

  1. How many years.... by DeathFlame · · Score: 4, Insightful

    ...till we make the Kwisatz Haderach?

    1. Re:How many years.... by Daniel+Dvorkin · · Score: 4, Insightful

      Yes, they could.

      They could also ... hmmm, I don't know, let's see ... on the basis of no actual science whatsoever, based on loony racial theories centered on things like hair color and head shape, decide that some groups are superior and others inferior, and start trying to breed the superior ones to create a race of supermen for world conquest, while putting the inferior ones in death camps. Or they could, based on loony economic theories centered on the writings of long-dead philosophers, decide that all property must be owned and distributed by the state, and kill anyone who disagrees with them. Or ... well, you get the idea. Honestly, on the list of Bad Things To Be Scared Of Governments Doing, abuse of genetic data gathered for an anthropology project is way down on the list.

      --
      The correlation between ignorance of statistics and using "correlation is not causation" as an argument is close to 1.
  2. Re:Huge DNA repository... by avandesande · · Score: 3, Funny

    What's the matter, you dont like Jenna Jamison?

    --
    love is just extroverted narcissism
  3. Preparing its defense by Anonymous Coward · · Score: 5, Funny

    This is really just an attempt by IBM to prepare a defense against SCO that shows that Wookiees do not, in fact, come from Endor.

  4. Re:Polishing the tin foil by WhatAmIDoingHere · · Score: 3, Funny

    Because we all know how EVIL National Geographic is!

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  5. I wonder... by hcob$ · · Score: 3, Funny

    if they accecpt other swabbing techniques? The "other" dna sources would probably get a huge male bias to the data though.

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  6. Re:Great by SUB7IME · · Score: 3, Funny

    Every time someone uses their hands to touch an envelope or their tongue to seal it, they are probably leaving trace amounts of *gasp* DNA on the envelope. OH NO! There's probably DNA floating around EVERYWHERE by now!

    And what if they sneezed a little virus particle onto the letter that they wrote to you!?

  7. Interesting by dfn5 · · Score: 5, Funny
    I can't wait for them to discover that humans started their migration 5,000 years ago when they were chased out of eden by the dinosaurs.

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    1. Re: Interesting by Black+Parrot · · Score: 3, Funny


      > I can't wait for them to discover that humans started their migration 5,000 years ago when they were chased out of eden by the dinosaurs.

      You're on to them! They were going to use the DNA to backtrace the migration and find the flaming sword, which they will sell on ebay for a pretty penny.

      --
      Sheesh, evil *and* a jerk. -- Jade
    2. Re:Interesting by HrothgarReborn · · Score: 4, Funny

      Quit being silly. We left Eden almost 6,000 years ago. Uneducated clod.

  8. What would be interesting... by jd · · Score: 5, Interesting
    Is to compare the results with Oxford Ancestors, who perform a very similar service and have done for some years now. OA claim to be able to pinpoint a region from which you are ultimately descended on the female line, and to make a good guess of the same on the male line.


    If OA's regions flat-out contradict NG's, then one or both sets of data must be wrong. A fatal flaw exists in an assumption that has been made. Which would be valuable to know, from a scientific standpoint, even if it would hurt sales.


    If the two agree, it isn't proof that they are accurate, but provided the work was independently carried out, it raises the chances that they really are onto something.

    --
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  9. Is it worth $100.00? by unk1911 · · Score: 5, Informative

    While the most useful samples will come from indiginous populations, members of the general public will be able to mail in their own DNA on special cheek swabs. for only $100.00 plus ship/handling"

    --
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    1. Re:Is it worth $100.00? by twiddlingbits · · Score: 3, Insightful

      $100 bucks? You gotta be kidding. I can have my dog DNA typed (same process) for only about $60 and if it is a rarer breed for FREE. And the same kind of historical genetic analysis is going on with the Canine Genome. The process of DNA typing is the same for any animal, so why do hoo-mans cost more than K-9s? Sounds like a nice revenue source for someone. With some research and some dicussion with your relatives you can trace your roots back pretty darn far. I mean who cares that your 1,000 times great grandparents were from some part of Africa? What value does this information add to society?

    2. Re:Is it worth $100.00? by Anonymous Coward · · Score: 5, Insightful

      Well, sir... the ancestral variation in the dog genome (partly since it is the result of centuries of artificial selection) is less than that in the human genome => fewer sites needed => cheaper. There is also an economy of scale, as I believe all AKC members are required to do this testing. BTW, the fact that the rarer breeds are done for "free" should indicate to you that this cost is being subsidized, perhaps by your AKC membership fees or someone else's (hint: nothing is really free).

      As far as "talking with your relatives", you might keep in mind that a lot of people aren't lucky enough to have living ones / know who they are. At any rate, no one is being forced to take this test.
      The benefit to society of tracking ancestral DNA is partly from these genealogical projects (who are you to say that orphans don't deserve to know why they have dark skin) and partly in setting up an ancestry-sensitive statistical "baseline" for other research. For a simple example, suppose that you're looking for the genes that cause sickle-cell anemia. If you do this without any ancestral knowledge at all, you're going to get thousands of false positives simply because sickle-cell anemia is correlated to African descent and African-descendants have different genetic frequency EVERYWHERE on the genome. A lot of this genetic variation is non-selective "drift" between population and should be ignored if you're looking for coding (or "metacoding") sequences.

      Before projects like this, the only reliable way to compensate for that bias was to do tedious pedigree studies (i.e. find families wherein, up to 2-3 generations back, some members had sickle-cell and some verifiably didn't). Novel statistical methods can take into account the ancestral correlation in ANY samples whatsoever, thus magnifying the power of disease-assays by 1000-fold in some practical cases.

      I'd say that that has "value to society" insofar as anything in biotech does. There are also some applications of these ancestry-sensitive approaches in forensics/law (yes, for both the prosecution and the defense - imho, it's a pretty neutral technology which makes for better information in court all around - the dystopian "GATTACA" stuff is still sci-fi).

      If you have any further questions, post in reply. I do this stuff for a living, though it's a little hard to explain well in a /. comment.

  10. Warning! by Anonymous Coward · · Score: 5, Funny

    These cheek swabs are not oral! You have been warned.

  11. Interesting stuff by ites · · Score: 4, Interesting

    Forget all the "big brother" comments.

    There have been some studies of human DNA and these have often produced very interesting results, showing accurately how people migrated across the globe.

    The problem up to now is that these have been relatively small studies confined to specific issues - such as the colonisation of the Pacific islands, which happened from Indonesia, not South America (sorry, Thor).

    A large-scale analysis of human DNA that includes Africa - the richest mix of DNA by far - will be very, very interesting.

    For example, there are theories that modern Africans are largely descended from relatively recent immigrants from the Indian Ocean basin who recolonised from the East coast and mixed with aboriginal Africans - such as the Khoi and San - eventually pushing these into the margins.

    Good stuff.

    --
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  12. Incremental Knowledge by 4of12 · · Score: 5, Interesting

    The African exodus I think is pretty well understood. Although, there seems to have been multiple exodi (?) of hominid species that did not survive in the long term (such as the Neanderthal in Europe).

    From what I understand, the story gets harder to piece together in the last part of the European migrations from Central Asia.

    A couple of interesting TV shows on this were The Real Eve (which does the mitochondrial trace through maternal ancestral lines), and Journey of Man, which relates to the more difficult task of tracing mutations in the Y chromosome handed done through paternal lines.

    One of the earlier pioneers in the field, Brian Sykes of Oxford, started up a side business where you can send swabs to obtain information about maternal and paternal markers in your genetic makeup (IIRC, about US$225).

    A few years ago I got the analysis done and sent the results back to Ma 'n Pa for Mother's Day and Father's Day gifts.

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  13. Fun with DNA samples by Anonymous Coward · · Score: 5, Funny

    I'd like too see their reaction if someone sent them the DNA of a chimpanzee... Given the similarity between the two DNAs, it might take them them a while to figure that one out...

  14. Our Complex History by J05H · · Score: 5, Interesting

    This is an interesting project, it will help to fill in the holes in the knowledge of our origins. Most cultures have legends of the journeys that led to settling a new home, with this research we will see much more clearly who went where,

    Here is the map I want to see more fully realized:

    http://www.mitomap.org/WorldMigrations.pdf

    There are interesting legends and recent research that Genographic project might help: were there Austronesian ("aborigine") migrations across the Pacific 40,000 years ago? Are modern Tibetans and Athapaskan speakers (Navaho) related through the so-called Amur River Culture? When and how often have the "X" haplogroups travelled to America, and were these only Neolithic migrations or did they occur throughout the Bronze and Iron ages? Finally, how much back-migration occured from the Americas to the Old World continents? I'm not the one to research it, but a correlation between Am-Indian oral lore and this geno-map could make for an interesting thesis.

    My guess is that the project will show far more migration than previously expected - humans are nothing if not mobile.

    josh

    --
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  15. historical linguistics by lovebyte · · Score: 3, Interesting

    Just a thought: Linking this DNA study to studies in historical linguistics could give interesting results. There must be some correlation between people's DNA and the language they use.

    --

    I'll do it for cheesy poofs.

  16. North and South America by sellin'papes · · Score: 3, Interesting
    I think some of the most interesting data will come out of studying migration of peoples into the americas.

    It is generally agreed that the first humans arrived in the americas around 25-30,000 years ago but their migration from that point on is a mystery.

    One belief is that they migrated south through a northern passage as the polar ice-caps melted. Another is that they migrated down the west coast from the north pole to south America befoer the ice-caps melted. There is a third (more controversial) theory that they migrated by boat from africa and then moved north up the continent.

    It will be interesting to see what conclusions are drawn.

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  17. Other research by kbahey · · Score: 4, Informative

    Some research on this was done before.

    There was also this fellow, British I think, who did a documentary about early human migration using genetics, he was on TV (PBS?) a few years back. Nice work. He showed that there were two waves out of Africa. One hugged the coastline reaching India then all the way to Australia, and another going to central Asia, then staying there for a while, and then a branch going west to Europe, and another going east to Siberia, Beringia, and eventually to the Americans. Can't remember his name. Rats!

    Some other resources:

    Scientists trace human migration using DNA.

    Wikipedia article on Human migration.

    Stephen Oppenheimer did a genetic map.

    Kurgan Genetics.

    Neanderthaals and mtDNA

  18. What's indigenous? by Silver+Sloth · · Score: 3, Insightful

    At the end of the day, unless you live in central Africa, and possibly not then, no one is truly indegenous. We're all immigrants at some point or another.

    OK, I know I'm nitpicking. As far as the spread of mankind etc. then the first arrivals are the indigenous population. Here in the west of Europe peoples have been coming ad going for several thousend years. Exactly who's indigenous is very complex.

    --
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  19. DNA is the ANTI CHRIST by daperdan · · Score: 4, Interesting

    Isn't it amazing that we can convict a suspect of murder with a 99.99% certainty using DNA evidence but the religious reject it if it goes against their beliefs.

    The best case of DNA invalidating a religion is Mormonism. The founder of Mormonism claimed to have translated a book that was written by a people that migrated from the Middle East to the American continent. He claimed that these immigrants were the "priciple ancestors" of the modern day American Indian.

    Well it turns out that DNA proves what science has been saying for years. The American Indian is of Asiatic decent. Any other examples of DNA destroying a religion?

  20. Re:Christians are the worst of the religions. by eratosthene · · Score: 3, Insightful

    > Any religion that claims to be the 'only religion' is obviously false. You'd have to be a half-wit to miss that logical fallacy.

    This doesn't make sense to me. It seems that if a religion did not claim to be the 'only religion', then why would any of its members cling to it at all? After all, if Christianity was just 'one of many' ways to God, why would people have any incentive to remain Christian? It makes more sense to infer (at least if you believe in a certain religion) that your religion must be the 'only religion', otherwise the central tenets of what 'religion' is fail.

    --
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  21. Re:Is this really science??? by kebes · · Score: 4, Informative

    For the recrod, this isn't the first study of human migratory patterns. Many migration routes are now well established, whereas others are in debate and should be studied further. This study will help establish better timelines, settle controversies, and maybe even provide fresh theories to be tested. They are not "fitting data to preconceived notions" just because they are using the current body of knowledge as a starting point for their study.

    AFAIK the African origins of humankind are fairly well established. The fact that genetic anthropologists decided to call the oldest known common male ancestor "adam" and the oldest female one "eve" just shows that they have a sense of humour and history, not that what they do is quackery.

    So, yes, it is science.

  22. This is frustrating... by gentlemen_loser · · Score: 3, Interesting

    There are TWO models detailing the origins of our species. One model is the Out-of-Africa model. This effectively states that Homo sapiens left africa and COMPLETELY replaced Home Erectus (found in China) and Homo sapiens neandertalensis in Europe with little to no inter-breeding. This is the current "popular" theory.

    However, there is another model called the multi-regional model that states Homo sapiens evolved sperately on each of the different continents. How could this happen you say? Because enough interbreeding went on to maintain species integrity. Proponents of the Out-of-Africa model tend to ignore fossil evidence from Dali China that shows a skull exhibiting charateristics closer to H. sapiens than H. erectus - pre-dating the earliest evidence from Africa. Or other evidence such as a blending of charateristics in the middle east (mix of Neanderthal/H. Sapiens): EXACTLY where you would expect to find that sort of thing.

    Check out the following link: http://dienekes.blogspot.com/2005/02/more-on-multi regional-model.html

    Or google: Milford Wolpoff http://www.google.com/search?hl=en&q=Milford+Wolpo ff

    The Out-of-Africanists are force fitting a theory on the existing data. Something they are able to get away with because the current "most popular" scientists (D. Johanson, Leekey) push it. Its unfortunate that politics has worked its way into science.

    Remember, you only find what you are looking for.

  23. Re:Is this really science??? by brontus3927 · · Score: 4, Interesting

    Acording to a program on the Discovery Channel, about 60,000 years ago, the population of homo sapiens sapiens was reduced to ~2000. The current hypothesis is that the supervolcano under Yellowstone erupted and caused world-wide havoc on the ecosystem causing mass die-offs in populations. It would be noted that around that time, the North American Interior Seaway is believed to have broken through (possibly because of the eruption) the land seperating it from the Atlantic Ocean. This breka would have caused world sea level to rise about 10 meters. In flat lying areas such as the middle east (considered the birthlace of civilization) this would have caused floods hundreds of miles inland. Correlates roughly to the story of Noah (world gets flooded and only a handful of people left to repopulate the Earth)

  24. Adam and Eve never met by curlyjunglejake · · Score: 3, Insightful
    There is nothing wrong with the conclusions contradicting eachother. These studies trace the migration of single loci, not entire critters. Loci don't move exactly like critters do; they are fluctuating in frequency and bottlenecking and doing a whole bunch of other fun stuff under the radar. Just because we have a mitochondrial eve and a Y chrome Adam does not at all mean these two mated with eachother. It just means that all other versions of those genes that didn't descend from these two were since snuffed out, by random chance, in the y chromosome case.

    Furthermore, the nomenclature is mischeivious: Adam and Eve never met. They probably didn't even live within 5 thousand years of eachother. All these studies show are that all existing versions of these genes trace back via a given series of mutations to a specific individual, which, usuing geographic data and some assumptions about migratory behavior and mutation rates, you can imply to have existed in a certain place and time. You can do this with any loci, and at some point in the past it fixes. Each gene goes back to a different individual in a different place. HLA genes go back to the earliest vertibrates.

    Don't freak out when you learn the truth about the garden.

  25. Racism and Polygenism by ajnsue · · Score: 4, Insightful

    One concern is that the folks may pervert the finding of this data to support one of two equally corrupt conclusions. One that finding a single lineage of all people (monogenism) endorses the Judeo-Christian beliefs in Adam & Eve. Or two that multiple sources of origin (polyenism) can justify racism - in that some lineages are "less" evolved than others. The dangers of these ideas are well documented by Louis Menand in his wonderful book "The Metaphysical Club"