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Global DNA Project to Study Human Ancestry

Steve writes "The National Geographic Society and IBM are teaming up to map the history of human migration using DNA. The Genographic Project aims to collect 100,000 genetic samples which will be used trace the movements of humans out of Africa and around the globe. While the most useful samples will come from indiginous populations, members of the general public will be able to mail in their own DNA on special cheek swabs."

18 of 325 comments (clear)

  1. How many years.... by DeathFlame · · Score: 4, Insightful

    ...till we make the Kwisatz Haderach?

    1. Re:How many years.... by Daniel+Dvorkin · · Score: 4, Insightful

      Yes, they could.

      They could also ... hmmm, I don't know, let's see ... on the basis of no actual science whatsoever, based on loony racial theories centered on things like hair color and head shape, decide that some groups are superior and others inferior, and start trying to breed the superior ones to create a race of supermen for world conquest, while putting the inferior ones in death camps. Or they could, based on loony economic theories centered on the writings of long-dead philosophers, decide that all property must be owned and distributed by the state, and kill anyone who disagrees with them. Or ... well, you get the idea. Honestly, on the list of Bad Things To Be Scared Of Governments Doing, abuse of genetic data gathered for an anthropology project is way down on the list.

      --
      The correlation between ignorance of statistics and using "correlation is not causation" as an argument is close to 1.
  2. Preparing its defense by Anonymous Coward · · Score: 5, Funny

    This is really just an attempt by IBM to prepare a defense against SCO that shows that Wookiees do not, in fact, come from Endor.

  3. Interesting by dfn5 · · Score: 5, Funny
    I can't wait for them to discover that humans started their migration 5,000 years ago when they were chased out of eden by the dinosaurs.

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    1. Re:Interesting by HrothgarReborn · · Score: 4, Funny

      Quit being silly. We left Eden almost 6,000 years ago. Uneducated clod.

  4. What would be interesting... by jd · · Score: 5, Interesting
    Is to compare the results with Oxford Ancestors, who perform a very similar service and have done for some years now. OA claim to be able to pinpoint a region from which you are ultimately descended on the female line, and to make a good guess of the same on the male line.


    If OA's regions flat-out contradict NG's, then one or both sets of data must be wrong. A fatal flaw exists in an assumption that has been made. Which would be valuable to know, from a scientific standpoint, even if it would hurt sales.


    If the two agree, it isn't proof that they are accurate, but provided the work was independently carried out, it raises the chances that they really are onto something.

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  5. Is it worth $100.00? by unk1911 · · Score: 5, Informative

    While the most useful samples will come from indiginous populations, members of the general public will be able to mail in their own DNA on special cheek swabs. for only $100.00 plus ship/handling"

    --
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    1. Re:Is it worth $100.00? by Anonymous Coward · · Score: 5, Insightful

      Well, sir... the ancestral variation in the dog genome (partly since it is the result of centuries of artificial selection) is less than that in the human genome => fewer sites needed => cheaper. There is also an economy of scale, as I believe all AKC members are required to do this testing. BTW, the fact that the rarer breeds are done for "free" should indicate to you that this cost is being subsidized, perhaps by your AKC membership fees or someone else's (hint: nothing is really free).

      As far as "talking with your relatives", you might keep in mind that a lot of people aren't lucky enough to have living ones / know who they are. At any rate, no one is being forced to take this test.
      The benefit to society of tracking ancestral DNA is partly from these genealogical projects (who are you to say that orphans don't deserve to know why they have dark skin) and partly in setting up an ancestry-sensitive statistical "baseline" for other research. For a simple example, suppose that you're looking for the genes that cause sickle-cell anemia. If you do this without any ancestral knowledge at all, you're going to get thousands of false positives simply because sickle-cell anemia is correlated to African descent and African-descendants have different genetic frequency EVERYWHERE on the genome. A lot of this genetic variation is non-selective "drift" between population and should be ignored if you're looking for coding (or "metacoding") sequences.

      Before projects like this, the only reliable way to compensate for that bias was to do tedious pedigree studies (i.e. find families wherein, up to 2-3 generations back, some members had sickle-cell and some verifiably didn't). Novel statistical methods can take into account the ancestral correlation in ANY samples whatsoever, thus magnifying the power of disease-assays by 1000-fold in some practical cases.

      I'd say that that has "value to society" insofar as anything in biotech does. There are also some applications of these ancestry-sensitive approaches in forensics/law (yes, for both the prosecution and the defense - imho, it's a pretty neutral technology which makes for better information in court all around - the dystopian "GATTACA" stuff is still sci-fi).

      If you have any further questions, post in reply. I do this stuff for a living, though it's a little hard to explain well in a /. comment.

  6. Warning! by Anonymous Coward · · Score: 5, Funny

    These cheek swabs are not oral! You have been warned.

  7. Interesting stuff by ites · · Score: 4, Interesting

    Forget all the "big brother" comments.

    There have been some studies of human DNA and these have often produced very interesting results, showing accurately how people migrated across the globe.

    The problem up to now is that these have been relatively small studies confined to specific issues - such as the colonisation of the Pacific islands, which happened from Indonesia, not South America (sorry, Thor).

    A large-scale analysis of human DNA that includes Africa - the richest mix of DNA by far - will be very, very interesting.

    For example, there are theories that modern Africans are largely descended from relatively recent immigrants from the Indian Ocean basin who recolonised from the East coast and mixed with aboriginal Africans - such as the Khoi and San - eventually pushing these into the margins.

    Good stuff.

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  8. Incremental Knowledge by 4of12 · · Score: 5, Interesting

    The African exodus I think is pretty well understood. Although, there seems to have been multiple exodi (?) of hominid species that did not survive in the long term (such as the Neanderthal in Europe).

    From what I understand, the story gets harder to piece together in the last part of the European migrations from Central Asia.

    A couple of interesting TV shows on this were The Real Eve (which does the mitochondrial trace through maternal ancestral lines), and Journey of Man, which relates to the more difficult task of tracing mutations in the Y chromosome handed done through paternal lines.

    One of the earlier pioneers in the field, Brian Sykes of Oxford, started up a side business where you can send swabs to obtain information about maternal and paternal markers in your genetic makeup (IIRC, about US$225).

    A few years ago I got the analysis done and sent the results back to Ma 'n Pa for Mother's Day and Father's Day gifts.

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  9. Fun with DNA samples by Anonymous Coward · · Score: 5, Funny

    I'd like too see their reaction if someone sent them the DNA of a chimpanzee... Given the similarity between the two DNAs, it might take them them a while to figure that one out...

  10. Our Complex History by J05H · · Score: 5, Interesting

    This is an interesting project, it will help to fill in the holes in the knowledge of our origins. Most cultures have legends of the journeys that led to settling a new home, with this research we will see much more clearly who went where,

    Here is the map I want to see more fully realized:

    http://www.mitomap.org/WorldMigrations.pdf

    There are interesting legends and recent research that Genographic project might help: were there Austronesian ("aborigine") migrations across the Pacific 40,000 years ago? Are modern Tibetans and Athapaskan speakers (Navaho) related through the so-called Amur River Culture? When and how often have the "X" haplogroups travelled to America, and were these only Neolithic migrations or did they occur throughout the Bronze and Iron ages? Finally, how much back-migration occured from the Americas to the Old World continents? I'm not the one to research it, but a correlation between Am-Indian oral lore and this geno-map could make for an interesting thesis.

    My guess is that the project will show far more migration than previously expected - humans are nothing if not mobile.

    josh

    --
    gigantino.tv - Heavy but weighs nothing.
  11. Other research by kbahey · · Score: 4, Informative

    Some research on this was done before.

    There was also this fellow, British I think, who did a documentary about early human migration using genetics, he was on TV (PBS?) a few years back. Nice work. He showed that there were two waves out of Africa. One hugged the coastline reaching India then all the way to Australia, and another going to central Asia, then staying there for a while, and then a branch going west to Europe, and another going east to Siberia, Beringia, and eventually to the Americans. Can't remember his name. Rats!

    Some other resources:

    Scientists trace human migration using DNA.

    Wikipedia article on Human migration.

    Stephen Oppenheimer did a genetic map.

    Kurgan Genetics.

    Neanderthaals and mtDNA

  12. DNA is the ANTI CHRIST by daperdan · · Score: 4, Interesting

    Isn't it amazing that we can convict a suspect of murder with a 99.99% certainty using DNA evidence but the religious reject it if it goes against their beliefs.

    The best case of DNA invalidating a religion is Mormonism. The founder of Mormonism claimed to have translated a book that was written by a people that migrated from the Middle East to the American continent. He claimed that these immigrants were the "priciple ancestors" of the modern day American Indian.

    Well it turns out that DNA proves what science has been saying for years. The American Indian is of Asiatic decent. Any other examples of DNA destroying a religion?

  13. Re:Is this really science??? by kebes · · Score: 4, Informative

    For the recrod, this isn't the first study of human migratory patterns. Many migration routes are now well established, whereas others are in debate and should be studied further. This study will help establish better timelines, settle controversies, and maybe even provide fresh theories to be tested. They are not "fitting data to preconceived notions" just because they are using the current body of knowledge as a starting point for their study.

    AFAIK the African origins of humankind are fairly well established. The fact that genetic anthropologists decided to call the oldest known common male ancestor "adam" and the oldest female one "eve" just shows that they have a sense of humour and history, not that what they do is quackery.

    So, yes, it is science.

  14. Re:Is this really science??? by brontus3927 · · Score: 4, Interesting

    Acording to a program on the Discovery Channel, about 60,000 years ago, the population of homo sapiens sapiens was reduced to ~2000. The current hypothesis is that the supervolcano under Yellowstone erupted and caused world-wide havoc on the ecosystem causing mass die-offs in populations. It would be noted that around that time, the North American Interior Seaway is believed to have broken through (possibly because of the eruption) the land seperating it from the Atlantic Ocean. This breka would have caused world sea level to rise about 10 meters. In flat lying areas such as the middle east (considered the birthlace of civilization) this would have caused floods hundreds of miles inland. Correlates roughly to the story of Noah (world gets flooded and only a handful of people left to repopulate the Earth)

  15. Racism and Polygenism by ajnsue · · Score: 4, Insightful

    One concern is that the folks may pervert the finding of this data to support one of two equally corrupt conclusions. One that finding a single lineage of all people (monogenism) endorses the Judeo-Christian beliefs in Adam & Eve. Or two that multiple sources of origin (polyenism) can justify racism - in that some lineages are "less" evolved than others. The dangers of these ideas are well documented by Louis Menand in his wonderful book "The Metaphysical Club"