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Merck's Deleted Data
An anonymous reader wrote to mention a Forbes article describing a drug study tampering proven by software. From the article: "A top editor of The New England Journal of Medicine says that he was stunned to find out that data linking Vioxx to cardiovascular risk was deleted from a major study his journal published five years ago--and that it appears that Merck researchers may have deleted that data ... When you hover the cursor over the editing changes, the identity of the editor pops up, and it just says 'Merck'"
It looks like Merck deleted this submission.
I got a 404 error when clicking on the 'Read more...' link. Damned multinationals!
You'd think after all the high profile cases of stuff like this happening, companies would be more careful with the revision history system. Guess not...
And you guys said that this feature was bad! They're just looking out for us, bless their hearts!
The researchers must have forgotten to slide the little "write protect" tab on the diskette.
Dark Reflection
The researchers still aren't sure whether Clippy's testimony will hold up in court.
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There are two types of people in this world: those that categorize other people and those that don't.
they are now testing on humans...
*''I can't believe it's not a hyperlink.''
Hey, man. This is the self correcting market, with it's free hand at work! Stop complaining, and sorry all you dead heart-attack guys.
"Speaking the Truth in times of universal deceit is a revolutionary act." -- George Orwell
"I was somewhere between surprised and stunned," Dr. Gregory Curfman, executive editor of The Journal, says. "They allowed us to publish an article that was just incomplete and inaccurate in some respects and was misleading and may have contributed to the detriment to the public health. " (emphasis added)
Now why would you allow to publish such inconclusive studies at all ? Is this journal peer-reviewed ? It would be interesting to see if they also publish the comments from the anonymous reviewers ? Did they agree about the paper before it got published ?
Nothing like getting busted by a your own inability to use secure document authoring tools.
Could this be the drug industry's "Firestone"? Yet another example of he classic irresponsible/corrupt/greedy corp. that tries to cover up its own blunders.
"At 3:00 P.M. today, Curfman and two other editors released an editorial on The New England Journal's Web site entitled "Expression of Concern," which calls on the VIGOR authors to submit a correction of the 2000 manuscript. "Taken together, these inaccuracies and deletions call into question the integrity of the data on adverse cardiovascular events in this article," it read. "
The editorial, however, is also strangely missing. In its place was a message: "Silly Scientists - morality is for kids! Love, Merck."
I know this thread is going to turn into a huge gripe on massive corporations and how corrupt and evil and bad they are... but... considering the company is being publicly humilated, it's stock is trading at half the price it was a 2 years ago, and it's hemorrhaging jobs. I think it's fair to say the free market is correctly punishing this big business that is supposedly "running the world". But that's just me.
It wasn't so much the data that was tampered with. I can almost guarantee you that Merck was not unblinded during the trial, and therefore wouldn't know which data to change. This article is talking about a scientific publication based on the study results, there are usually many publications resulting from any study. At this point, several institutions, including Merck, a data safety board, and an independent statistical data center would complete copies of the original data, so any changes at Merck would be caught by these people (in theory).
What the Journal found, was that someone at Merck had included a table on CV events in an early version of the manuscript, and then deleted it. So this isn't really tampering with data, it's not including all the data in your conclusions. It's not including data that shows potential harm to patients. It could be argued that this is tantamount to the same thing, which I'm not disagreeing with. Merck's defense is that the events in question occured after some pre-specified cut off date for analysis, who knows if that is true or not.
$sys$data_unfavorable_to_merck
Eloi are stupid, throw morlocks at them!
Well, I'm glad that the issues has finally come to light. I heard someone else suspected something along these lines before, but he became Fugitive when he murdered his wife.
The only problem with this is that this information is easily forged. It would be VERY EASY for someone to frame someone else this way. I'm not saying Merck didn't do it in this case. I'm just saying that even someone with no computer knowledge can change their user name in Word, make some changes, and have it appear as if someone else made the edit.
Although targeted at financial data, legislation such as the Sarbanes-Oxley Act is precisely what is needed in such high-risk industries. It imposes strict information controls and audit requirements, and makes an effort at putting the responsibily where it belongs, namely at the Director and Executive levels.
ascii art
Which president? Both Clinton and Bush strongly asserted that Iraq had WMDs during their tenure.
A Government Is a Body of People, Usually Notably Ungoverned
All industries are after lots of money. Grow up and get a clue. What makes Merck wrong in this instance is that they decided that the money was more important than the ethics.
I could care less how you or anyone else makes money, so long as you do it legally and honestly.
A Government Is a Body of People, Usually Notably Ungoverned
In related news the makers of Viagra were saying that their studies posted on the internet were "standing up" really well.
And how many people had their health sacrificed to get us to this point? For that matter, what punishment is occurring to those who did the evil deeds?
Nope, the free market is doing too little to late, as always.
And, BTW - it's not the corporation that's corrupt and evil, it's the people at the top of the corporations, who are immune to the evil that they do, unless they make mistakes in covering up their deeds.
they should have deleted lore instead!
where i work, we enforce use of the Remove Hidden Data Tool to prevent this happening
we once got some documents from DOJ that were supposed to go up on our website that had obvious edditing changes in them
The grass is always greener on the other side of the light cone.
Open Office is great for "fixing" broken Word documents. Macro virus? Corruption? No problem! Save as Oasis,then save back as .DOC. Problem solved. I'm sure Open Office can also "fix" version tracking as well.
Only goes to show you that it pays to use F/OSS.
Knowledge is power. Knowledge shared is power multiplied.
Maybe they just deleted the table from the article because they couldn't figure out how to format it in LaTEX.
I doubt the economy would keep bad people from doing bad things. However, if all corporate executives were held to task for their intentional failures, we would likely see less of this sort of thing. The problem, in my opinion, isn't capitalism, it seems more like the current incarnation of capitalism that has spawned mega-corporations where the "bad people" can often hide behind the faceless 'entity'. We're doing better now than we were at the start of the 20th century, but we still have much we can improve upon, personal responsibility and liability are at the top of the list (IMO).
Get a life, not a lifestyle. - Hikem Bey
When Donald Rumsfeld was head of R.G. Serle they were doing FDA safety studies for Aspartame (later branded as NutraSweet). Several rodents in the safety study died of brain cancer, but Serle removed them from the study and the data. A PhD working on the project blew the whistle. Congress investigated, hiring two lawyers to continue their work. A couple years later the acting head of the FDA, as his final act before resigning, approved NutraSweet. He then appeared as the legal eagle for NutraSweet. Guess who his two assistants were... Right.
Aspartame breaks down in warm water to release Methyl Alcohol, among other things, which causes cancers of the brain, eye, kidneys and liver. It can cause, like it did in me, a red flush over the upper half of the body and the face, and severe oil production by the Sebaceous glands, and a continual headach. It is associated with memory loss. My once nearly photographic memory is now gone.
Rumsfeld got $6M for his "work".
Running with Linux for over 20 years!
It looks like you are writing a drug study document. Would you like help deleting data?
When I heard this news about Merck, my impression was "deja vu". I recently read a book entitled "Overdosed America: The Broken Promise of American Medicine" by John Abramson. The author is not some quack. He teaches medicine at Harvard Medical School. He makes a strong point that drug tests which used to be funded by unbiased sources and now mostly funded by drug companies. They tailor the tests and massage the results to arrive at the conclusions that they are looking for. Before you take any prescription medicines, I strongly recommend that you read that book!
With that said, aspartame *can* break down into methanol, but usually only does so at extreme pH or temperature. Warm water alone very slowly hydrolyzes aspartame. I'm trying to find some good kinetics studies; this one indicates 90% hydrolysis after 53 days at 25 degrees C which is a good argument for only drinking refrigerated pop.
But the sheer amount you'd have to drink to produce blindness is astounding. I once calculated that with 100% hydrolysis, it would take 20 cans of pop per hour to build up and maintain harmful concentrations of methanol in the blood. EPA studies have indicated that 0.5g/kg/day doesn't result in observable health problems. There are (Google calculator r00lz) 0.014g of methanol per can of 100% hydrolyzed Coke. Hm, so that indicates that you probably don't want to drink more than 35 cans per day or you'll be above the no-observed-adverse effect level.
The official Materials Safety Data Sheet for methanol lists "Carcinogenicity: Methyl Alcohol - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA." That doesn't mean it's not carcinogenic, but it does mean that none of them has ever found any evidence for it being carcinogenic, as opposed to things like the nitrites in bacon, which have definite carcinogenic activity. The point being: we're eating things that are probably orders of magnitude more carcinogenic than the released methyl alcohol in aspartame; our bodies produce more methyl alcohol and its metabolites naturally than any but the most aggressive pop drinker will ever experience.
I'm not defending aspartame's use, but if you're going to attack what the FDA did when they certified it for use, attack it on other grounds, like your observed reaction to it, rather than because of methanol.
Nostalgia's not what it used to be.
The former CEO (left early 2005) walked off with some $17 million in compensation. Merck could be penalized hard but the guy who was in charge will have absolutely nothing done to him.
A radio maverick jumps to internet only. The Future of Rock n Roll
So, you're saying that if the company can select a cutoff date that's too soon, they can avoid a lot of hassle using your system?
I'm not arguing one side ot the other. My point is simply that there are two points of view and it is not so black and white.