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Facing the Dangers of Nanotech

bethr writes "Technology Review has a Q&A with Andrew Maynard, the science advisor for the Woodrow Wilson International Center's nanotechnology project regarding the dangers of nanomaterials and why we have to act now." From the article: "Individual experiments have indicated that if you develop materials with a nanostructure, they do behave differently in the body and in the environment. We know from animal studies that very, very fine particles, particles with high surface area, lead to a greater inflammatory response than the same amount of larger particles. We also know that they can enter the lining of the lungs and get through to the blood and enter other organs. There is some evidence that nanoparticles can move into the brain along the olfactory nerve, so this is completely circumventing the blood-brain barrier."

172 comments

  1. I smell nanoparticles... by Anonymous Coward · · Score: 5, Funny

    Arrrgh! help! they're in my brain!

    1. Re:I smell nanoparticles... by SueAnnSueAnn · · Score: 0

      Great idea for a weapon, Isn't it?

      Sue

      When it's time,
      it's time
      and it may be sooner then you think.

    2. Re:I smell nanoparticles... by Thansal · · Score: 1

      not unless we can reliably clean up after them.

      And so long as we don't care about destroying the local exosystem (unless we can make something that will only assault human brains).

      Then again, I thought that biological/chemical warfare was one of those big nonos that we all sorta agreed on....

      --
      Do Or Do Not, There Is No Spoon, There Is Only Zuul. Everything in the above post is probably opinion.
    3. Re:I smell nanoparticles... by cyfer2000 · · Score: 4, Interesting

      Great idea to treat brain cancer too.

      The idea is to modify certain magnetic nanoparticles so that they can attach to the cancer cells. Then by applying a vibrating magnetic field, we make make the nanoparticles vibrate and generate heat. As a result, the cancer cells get killed and the amount of affected good cells is very small.

      But, I think I need a tin foil hat.

      --
      There is a spark in every single flame bait point.
    4. Re:I smell nanoparticles... by joto · · Score: 1

      Then again, I thought that biological/chemical warfare was one of those big nonos that we all sorta agreed on....

      If it was, there'd be no reason for your government to invest money into defending itself from the stuff, no?

      I'd say most people/organisations/government/etc are only against ABC warfare untill the opponent uses it against you, and there are reasonable chances that a similar attack by you will harm your opponent enough to at least temporarily stop the attacks against you. I.e people are against ABC weapons in the same way they are against violence. Only untill someone punches you in the nose.

    5. Re:I smell nanoparticles... by couchslug · · Score: 1

      What is the potential for nanoparticle chem warfare agents?
      Nanoparticles should disperse quite well, and if they get past conventional filters they could obsolete billions of dollars in NBC defenses.
      Is a nanoparticle dirty bomb practical?

      --
      "This post is an artistic work of fiction and falsehood. Only a fool would take anything posted here as fact."
    6. Re:I smell nanoparticles... by Ash+Vince · · Score: 3, Insightful

      Anyone thinking of designing a nanotech weapon of this kind needs to go and read the short story by Philip K Dick called Second Variety.

      --
      I dont read /. to RTFA, I read /. to offend people in ignorance.
    7. Re:I smell nanoparticles... by Reziac · · Score: 1

      Couldn't this idea be expanded, to treat any specific tissue type? Bone leaps to mind, for cancer or infection -- bone infections being generally difficult to treat due to relative lack of blood supply.

      --
      ~REZ~ #43301. Who'd fake being me anyway?
    8. Re:I smell nanoparticles... by Schraegstrichpunkt · · Score: 1
      not unless we can reliably clean up after them.

      Like that's ever stopped anyone. Doesn't the U.S. still deploy land mines?

    9. Re:I smell nanoparticles... by Anonymous Coward · · Score: 0

      That tin foil hat might interfere with the magnetic field.

    10. Re:I smell nanoparticles... by cyfer2000 · · Score: 1

      I am not familiar with the blood system of bone. But it should work.

      --
      There is a spark in every single flame bait point.
    11. Re:I smell nanoparticles... by cyfer2000 · · Score: 1

      Can't you see that those magnetic nanoparticles are a great idea to manipulate brain function? Where is my tin foil hat...

      --
      There is a spark in every single flame bait point.
  2. But, but, but... by LiquidCoooled · · Score: 1, Interesting

    Haven't we had nanotechnology for ages?

    Didn't I just read something about ancient swords using nanotubes?

    --
    liqbase :: faster than paper
    1. Re:But, but, but... by naoursla · · Score: 5, Funny

      Yes, and having one of those enter your brain along your olfactory nerve can cause serious health issues.

    2. Re:But, but, but... by LiquidCoooled · · Score: 1

      How the hell is that offtopic?

      We have been using nano particles for centuries and they have existed for much longer.

      --
      liqbase :: faster than paper
    3. Re:But, but, but... by CCFreak2K · · Score: 2, Funny

      It's been known to cause mild death in most cases as well.

      --
      "Beware of he who would deny you access to information, for in his heart he dreams himself your master."
  3. IT'd be nice to see some actual nanotech ... by thrillseeker · · Score: 4, Insightful

    ... worthy to be afraid of.

    1. Re:IT'd be nice to see some actual nanotech ... by Dan112476 · · Score: 1

      "I, for one, would like to welcome our Gray Goo overlords"?

  4. In sum by ch-chuck · · Score: 5, Funny

    Nanotech: The Asbestos of the Future.

    As Mork would say, "Nano, Nano!"

    --
    try { do() || do_not(); } catch (JediException err) { yoda(err); }
  5. Gray Goo by Anonymous Coward · · Score: 0

    That isn't exactly what is usually called "gray goo" by nanotech critics, but nanostructures entering the brain comes pretty close.

    1. Re:Gray Goo by Aqua_boy17 · · Score: 1

      I know plenty of people with gray goo for brains and it had nothing to do with nanotech. Hydroponics, maybe, but not nanotech.

      --
      What if the Hokey Pokey really is what it's all about?
    2. Re:Gray Goo by x2A · · Score: 1

      I know plenty of people with nano brains!

      --
      The revolution will not be televised... but it will have a page on Wikipedia
  6. Nanomaterial == molecules by gregor-e · · Score: 2, Insightful

    Since assembly-based nano isn't anywhere near yet, whenever news articles use the term 'nano', what they really mean is something more like 'chemical' or 'molecular'. TFA is no exception, really. So when he says 'There is some evidence that nanoparticles can move into the brain along the olfactory nerve, so this is completely circumventing the blood-brain barrier.' we can easily translate this as saying 'There is some evidence that molecules can move into the brain along the olfactory nerve, so this is completely circumventing the blood-brain barrier.' Yeah, some molecules can pass the blood-brain barrier. What's his point? It's all nano-FUD, IMO.

    1. Re:Nanomaterial == molecules by Saige · · Score: 5, Funny

      OMG! The three-quarteres of the Earth is covered in very deep bodies of liquid nanoparticles! Even worse, the atmosphere now consists almost entirely of nanoparticles! We inhale huge amounts of them with every breath!

      WE'RE ALL GONNA DIE!

      --
      "You know your god is man-made when he hates all the same people you do."
    2. Re:Nanomaterial == molecules by Anonymous Coward · · Score: 1, Informative
      Since assembly-based nano isn't anywhere near yet, whenever news articles use the term 'nano', what they really mean is something more like 'chemical' or 'molecular'.

      No, they mean really-finely-ground-up-stuff, that's a lot bigger and more complex than the sort of thing (oxygen molecules or glucose) that normally crosses the blood-brain barrier.

    3. Re:Nanomaterial == molecules by Anonymous Coward · · Score: 2, Insightful

      What's his point? It's all nano-FUD, IMO.

      I think his point is that we are dealing with familiar materials in unfamiliar configurations. When dealing with anything unknown a certain amount of uncertainty, doubt, and yes, even fear or trepidation is called for.

      Sure you can probably get away with treating that which is unknown in a cavalier fashion, making the assumption that it is perfectly safe until otherwise demonstrated to be unsafe. But of course when approaching that which is unknown in this fashion there are always going to be the cases where things that are unsafe are not recognized as such until something bad happens.

      Maybe these things ring a bell: lead, radium, thalidomide.

      Even things which are generally recognized as safe when handled or used properly can still be unsafe when misued. I won't bother listing examples of these. Your house and surrounding environment are packed with them.

    4. Re:Nanomaterial == molecules by A+beautiful+mind · · Score: 4, Insightful

      I was originally going to write a post to show that you might not be totally justified in what you're writing, but then I realised that nano is the SI prefix for 10^-9, while a hydrogen molecule is 1.06 * 10^-10m, so you might not be completely off in saying that this is nothing new, so this is one score to you.

      However, I have to mention that the size might not be the problem, but rather the properties of these nanoparticles.

      The most important thing to remember when talking about nanoparticles, is that a lot of these materials have a unique thing in common, quoth wikipedia, "vastly increased ratio of surface area to volume". Remember for example lunar dust and the problems associated with it? Imagine that effect on a much worse level.

      --
      It takes a man to suffer ignorance and smile
      Be yourself no matter what they say
    5. Re:Nanomaterial == molecules by Ken+D · · Score: 5, Insightful

      No, this is not FUD. Forget gasses and liquids, this is about solids. Solids come in non-molecular chunks. Out bodies (and the bodies of every other living thing out there) are accustomed to encountering solids that are in fairly large sized chunks. If you can find a way to process those solids into much smaller chunks then you have a nano-material. This is the stuff that's dangerous. It's true of non-nano tech too. For example if I had a large piece of asbestos, that's not really dangerous, but if I pulverize it into dust it is. These new nano materials open up the possibility that alot more materials could be dangerous.

      If I swallow a quarter, ....it'll pass. What if I swallowed something that contained a quarter shredded into pieces no larger than 100nm, will that pass? Or will large amounts get trapped in various nooks and corners in my guts, and what effect will it have if those bits stay there for 30 years? What if I breathe it into my lungs? Will it do something like asbestos dust?

      See http://www.kemcointernational.com/NANOPHASEAPPLICA TIONS.htm for cosmetics and foot powder containing Iron Oxide and Zinc Oxide nano materials that you can easily ingest or breathe.

    6. Re:Nanomaterial == molecules by Anonymous Coward · · Score: 0

      A tiny crystal isn't really a molecule, and you rely on millions of years of evolution to protect you against molecules you may encounter in everyday life. Some of the nanoparticles that are engineered are totally new, so your body can't be prepared for them.

    7. Re:Nanomaterial == molecules by Anonymous Coward · · Score: 5, Funny

      > We're all gonna die!

      Correct.

    8. Re:Nanomaterial == molecules by Captain+Jack+Taylor · · Score: 0

      I'd mod this up if I had mod points, this guy's right. I for one am strongly concerned about some of the applications here, we've seen similar idiocy in the past.

    9. Re:Nanomaterial == molecules by MikeFM · · Score: 1

      While I don't think they shouldn't study the dangers of these new materials I think the extremist that start calling for us to abandon such new technologies are idiots that ought to be ignored. As with anything new we should carefully study it and see what the risks and benefits are and how we can lower the risks while increasing the benefits. Science isn't always safe. What major breakthrough has ever happened where someone wasn't hurt along the way? How many people died or suffered horrible damage from X-Rays for example? Would we have been better off having never developed X-Ray technology into working products?

      Throwing experimental materials into cosmetics is a little rash but I expect they ran lab tests on the materials first. If it's not immediately dangerous then you might as well give it a shot. Maybe it's sad but mass product releases often are the best test. It could take 30 years of careful testing to find out the results you'd get by just releasing it on the public. People get sick and die from eatting vegetables so you have to realize that life is never going to be fully safe.

      If it doesn't kill us all in it's infancy I expect nano to make most of us live a lot longer and higher quality of life. It's worth a few risks.

      --
      At what price learning? At what cost wisdom? The price is a man's peace of mind, and the cost is his life.
    10. Re:Nanomaterial == molecules by Anonymous Coward · · Score: 0

      You do realize that killing other people (outside of self defense) for your personal gain is the height of sociopathy, right? Were you planning on donating the possibly deadly products to the public for testing, or just letting them pay for the privilege of dying to improve your quality of life?

    11. Re:Nanomaterial == molecules by cweber · · Score: 4, Insightful

      I find your post rather callous. While you may be right that breakthroughs don't happen without associated risks and the occasional negative or outright dangerous result, I believe we've been extremely careless during the 20th century. Your Xray example is a good one. Physicists and biologists knew fairly early on Xray radiation was ionizing, but for quite some time it didn't occur to anyone to not expose themselves or others to high doses. How hard would it be to remain a bit cautious? And maybe save a few lives and make countless other better in the process.

      TFA simply advocates caution and diligent research into negative consequences of nanotech while the technology is being developed. TFA never urges abandoning anything. I agree with the author that we should keep close tabs on this stuff and watch it for long term effects.

    12. Re:Nanomaterial == molecules by Anonymous Coward · · Score: 0

      Precisely.

    13. Re:Nanomaterial == molecules by cyfer2000 · · Score: 1

      Even worse again, almost all of the land on the Earth are covered with nano-layer or nano-needle like stuff named clay. And those black heart constructors even use the clay product to build houses!

      --
      There is a spark in every single flame bait point.
    14. Re:Nanomaterial == molecules by kabocox · · Score: 1

      OMG! The three-quarteres of the Earth is covered in very deep bodies of liquid nanoparticles! Even worse, the atmosphere now consists almost entirely of nanoparticles! We inhale huge amounts of them with every breath!

      WE'RE ALL GONNA DIE!


      Yeap, usually in around 78 years is the average amount of time it'll take nano particles of water vapor in the atmosphere to kill you. I invite you to experiment breathing other types of atmospheres to see how long you life though.

    15. Re:Nanomaterial == molecules by x2A · · Score: 1

      "nano particles of water vapor in the atmosphere to kill you"

      I don't think it's that which kills you...

      --
      The revolution will not be televised... but it will have a page on Wikipedia
    16. Re:Nanomaterial == molecules by The+Great+Pretender · · Score: 1

      do they measure them to make sure that they are all in the nanometer range? What ever happened to the micromaterials, are they running around unchecked? Did we just skip those guys? What if nanoparticles sick together, do they become microparticles or are they just a bunch of nanoparticles stuck together?

      --
      A positive attitude may not solve all your problems, but it will annoy enough people to make it worth the effort.
    17. Re:Nanomaterial == molecules by MikeFM · · Score: 1

      Caution is not a good way to make rapid advancements. Danger is inherit in discovery. Not that I'd suggest they not do lab work first to try to make products safe before exposure to the public but I think we do more harm to ourselves by being overly cautious. How many more people will die by slowing nanotech development to half speed compared to the people who might die if we race ahead at full speed? I get so angry when I see people protesting nanotech, genetics, stem cell research, etc. These have a strong likelyhood to provide wonder drugs in the near future but stupid people want to stop their advancement because there are minor risks. Not that the article is doing that - but I've seen a lot of people do it. IMO even if these technolgoies kill 95% of the population in the short-term it'd be worth it in the long-term because they'll make future generations so much stronger and more advanced. Consider it making us extinct for the benefit of those that evolve from us if you like.

      --
      At what price learning? At what cost wisdom? The price is a man's peace of mind, and the cost is his life.
    18. Re:Nanomaterial == molecules by wtansill · · Score: 2, Funny
      If I swallow a quarter, ....it'll pass. What if I swallowed something that contained a quarter shredded into pieces no larger than 100nm, will that pass?
      Either way I don't want the quarter back....
      --
      The contest for ages has been to rescue liberty from the grasp of executive power. -- Daniel Webster
    19. Re:Nanomaterial == molecules by Anonymous Coward · · Score: 0
      IMO even if these technolgoies kill 95% of the population in the short-term it'd be worth it in the long-term because they'll make future generations so much stronger and more advanced.
      Well, as long as you're the first to go I guess I might buy it...
    20. Re:Nanomaterial == molecules by Anonymous Coward · · Score: 0

      This is a rather academic discussion, don't you think? Unless the amount of money to be made is small and the risks are extremely likely and obvious, it will be done. Global markets will make sure that the scientists do not have to go to some remote country, because nothing is too dangerous or immoral when you tell people that not participating kills jobs and could cause the country to lose its technological edge. Same goes for stem cell research and biotechnology in general. The economy has you.

    21. Re:Nanomaterial == molecules by MagusSlurpy · · Score: 1

      Properties depend on size. Carbon, silicon, germanium, and tin (IV) are all more stable than their (II) counterparts, and normally will form four bonds. Being in the same group, we would expect lead to do the same. Lead (IV), on the other hand, is less stable than lead (II), because the electrons in the 6s orbital are kept close enough to the nucleus (far enough away from the p orbitals) that they don't take part in bonding, and so only the 2 5p electrons will form bonds. This characteristic is based entirely on size, the difference increases as you move down the group, it's just a matter of reaching limits.

      --
      My sister opened a computer store in Hawaii. She sells C shells by the seashore.
    22. Re:Nanomaterial == molecules by Anonymous Coward · · Score: 0

      Someone should mod that a-hole Troll. If he's not a troll then he's the kind of person The Constant Gardener was made about.

    23. Re:Nanomaterial == molecules by kabocox · · Score: 1

      "nano particles of water vapor in the atmosphere to kill you"
      I don't think it's that which kills you...


      Shh, I want to see if they'll experiment with breathing non-oxygen atmospheres in an attempt to experimentally extend their life. If anyone attempts this experiment, I'm fairly certain they'll be in the running for a Darwin Award. Come on any one want to try to win an award?

    24. Re:Nanomaterial == molecules by x2A · · Score: 1

      There's an award in it?!! Oh count me in then! :-)

      --
      The revolution will not be televised... but it will have a page on Wikipedia
    25. Re:Nanomaterial == molecules by Iron+Condor · · Score: 1

      Yeah, some molecules can pass the blood-brain barrier.

      The whole point of the statement you quoted was that it is not necessary to pass the blood-brain barrier if you can enter the brain through the nose. But that might have been to subtle...

      --
      We're all born with nothing.
      If you die in debt, you're ahead.
    26. Re:Nanomaterial == molecules by Iron+Condor · · Score: 1
      "nano particles of water vapor in the atmosphere to kill you"
      I don't think it's that which kills you...
      Shh, I want to see if they'll experiment with breathing non-oxygen atmospheres [...]

      What exactly does water vapor have to do with oxygen? That's just incoherent.

      --
      We're all born with nothing.
      If you die in debt, you're ahead.
    27. Re:Nanomaterial == molecules by ultranova · · Score: 1

      What if nanoparticles sick together, do they become microparticles or are they just a bunch of nanoparticles stuck together?

      I dunno, how would you consider your body ?-)

      --

      Forget magic. Any technology distinguishable from divine power is insufficiently advanced.

  7. Marketing is everything by realmolo · · Score: 4, Funny

    All that the producers of nanomaterials need to do is put a cartoon Camel on the box, and all the cool kids will be breathing nanonmaterials.

    They're perfectly safe, and prevent acne.

  8. Blood Music by Anonymous Coward · · Score: 0

    Coinciding with the recent Greg Bear questions as /., Blood Music is an excellent short story by him that offers once such nightmare scenario. Friggin awesome btw.

  9. Re:Off-topic... by LiquidCoooled · · Score: 3, Funny

    Oh crap!

    You mean you can see the Experimental threading indicators?
    Thats bad - it means the nano threading weaved into the webpage has escaped and made its way into your optic nerve.

    In reality I don't know and was wondering the same myself.

    --
    liqbase :: faster than paper
  10. More idiots by www.sorehands.com · · Score: 2, Insightful

    Lets see, they advocate the government looking over the shoulder and using Wikipedia to determine danger.

    First, there is a problem with governmental idiots in charge of something they don't understand.

    Two, I don't buy Wikipedia as an authoritative source. While it is source, it could be a start point, not an end point.

    And of course this would not apply to marketing hyped products -- the nano-tech car wax and nano-tech hair shampoo; Right???

  11. Blood brain barrier, eh? by 192939495969798999 · · Score: 2, Funny

    I've been working with nanotech for years, and I haven't noticed any brain damage-amage-amage-amage-amage.

    --
    stuff |
  12. missed the memo by netsfr · · Score: 1

    can someone forward me the memo about today being Nanotech day on /.?

    1. Re:missed the memo by LiquidCoooled · · Score: 1

      The memo is displayed on the front page, however the font size is so small you need an electron scanning microscope to read it.

      --
      liqbase :: faster than paper
    2. Re:missed the memo by j79zlr · · Score: 1

      It should be stapled to the TPS report, I'll get you a copy.

      --
      I'm not not licking toads.
    3. Re:missed the memo by Mister+Whirly · · Score: 1

      Sorry, but the memo went into my brain along the olfactory nerve, completely circumventing the blood-brain barrier.

      --
      "But this one goes to 11!"
  13. Yum! by tttonyyy · · Score: 2, Funny
    There is some evidence that nanoparticles can move into the brain along the olfactory nerve, so this is completely circumventing the blood-brain barrier.
    Anyone want to try my NanoBeer?

    It will happen, you know it.
    --
    biopowered.co.uk - catalytically cracking triglycerides for home automotive use since 2008. Just say no to big oil!
    1. Re:Yum! by maxume · · Score: 1

      You can't make stuff up fast enough anymore:

      http://www.nanotechbuzz.com/50226711/better_beer_t hrough_nanotechnology.php

      This isn't something I had seen before, it was a I-bet-if-I-type-that-into-Google thing.

      --
      Nerd rage is the funniest rage.
  14. Welcome! by ottc777 · · Score: 0, Redundant

    I for one welcome our small nanoverlords

    --
    this amount of stupidity usually requires a group of people
  15. Nature is full of nanoparticles by Anonymous Coward · · Score: 1, Insightful

    This seems to be a rising hobby, alarmism as a way of raising your personal profile. It happens every few years with each new technology, and the facts are no deterrant.

    The facts in this case are that the natural environment is FULL of nanoparticles of all sizes --- we live in a sea of them. Nature doesn't have any personal preference for particles of any given size.

    To say that something we manufacture could be dangerous is fine, but singling out nanoparticles is just plain silly. And yes, materials of all kinds change their properties depending on particle size. Again, singling out nanoparticles for this honour is more about alarmism than about objectivity.

  16. More Fun... by eno2001 · · Score: 2, Funny

    ...than a packet of greased up Yoda Dolls on a Saturday night at Karl Rove's place when Jim Jeff comes over. Wootz!!!

    --
    -"...bad old ideas look confusingly fresh when they are packaged as technology" - Jaron Lanier (Digital Maoism on Edge.o
    1. Re:More Fun... by LiquidCoooled · · Score: 1

      Wootz is more ontopic than you thought...

      --
      liqbase :: faster than paper
    2. Re:More Fun... by eno2001 · · Score: 1

      Yes... why do you think I put that there in the first place. Sharpened blades from Damascus anyone???

      --
      -"...bad old ideas look confusingly fresh when they are packaged as technology" - Jaron Lanier (Digital Maoism on Edge.o
  17. You know what this means... by hsmith · · Score: 3, Insightful

    If there are "dangers" associated with them, they will be PERFECT for the DoD to pickup on and investigate.

    what would be better than a bomb that goes off and you breathe in particles that can easily penetrate your organs

    1. Re:You know what this means... by Metasquares · · Score: 1

      That would probably be classified as a type of chemical weapon.

    2. Re:You know what this means... by Anonymous Coward · · Score: 0

      nano-bombs are cool, but i've got a better idea:

      a bomb that goes off and small (but not nano) pieces of jagged metal (let's call them 'shrapnel') get shot through your body at very high speed. pretty revolutionary, eh?

    3. Re:You know what this means... by Deoxyribose · · Score: 2, Interesting

      Neal Stephenson had the idea in his book "The Diamond Age." IIRC they were called cookie cutters and used in prisions to discourage escape and as a method of execution. The book is one of my all time favorites and a great read for anyone remotely interested in nanotech.

    4. Re:You know what this means... by Anonymous Coward · · Score: 0

      Er..left out that they were nanotech and ingested. Bleh

    5. Re:You know what this means... by Kattspya · · Score: 1

      There are alredy bombs with very fine shrapnel I'm not sure on which scale. They do now how ever work as you would think. The weapon class is called DIME

  18. Disappointed by Non-CleverNickName · · Score: 1

    I for one am shocked that The Magic School Bus conviently decided not to warn us of these dangers of nano-scaled foreign objects travelling through the human body :(

    --
    This is my signature. There are many like it but this one is mine.
  19. That's NOT what he is advocating! by CyberLord+Seven · · Score: 1, Offtopic
    First, from the article:

    The Widipedia idea is something that has been talked about. And I think that either that or something like that is a very exciting idea. Of course you've always got the issue of validating the information which is there. (emphasis mine)

    Second:

    That's where you come down to talking about "oversight" rather than regulations. (some content removed) So there are ways of dealing with challenges in the near future that don't necessarily mean resorting to regulation.

    Given Andrew Maynard's actual comments I don't see why you have to call him an idiot. In many ways he agrees with you.

    --
    We have always been at war with Eurasia!
  20. Re:Off-topic... by Anonymous Coward · · Score: 0

    they don't know how to do experiments on a test database, but instead do it on the live one. Typical.

  21. wouldn't you just know... by stupidsocialscientis · · Score: 1

    a guy that deals with nanotubes is going to have a difficult time understanding the relative size of a problem, and blows it all out of proportion. Nanotubes are small... you know- kinda like atoms, we don't worry about atoms do we? silly.

    --
    Well, as far as Sig's go, Freud was a doozy.
  22. Down with the Precautionary Principle! by adavies42 · · Score: 3, Insightful

    Progress requires risk. Deal.

    --
    Media that can be recorded and distributed can be recorded and distributed.
    -kfg
    1. Re:Down with the Precautionary Principle! by giafly · · Score: 1
      Progress requires risk. Deal.
      True, some risk, but the issue is whether this example of progress increases overall risk.
      --
      Reduce, reuse, cycle
    2. Re:Down with the Precautionary Principle! by Vellmont · · Score: 1


      Progress requires risk. Deal.

      On some level, I agree. The question of course is how much risk, and how do you manage that risk?

      I'd hope you wouldn't argue that we totally eliminate the FDA and just let people deal with the risks of the effects of untested drugs. That would be, IMO, insane.

      The arguments in the article seem entirely reasonable to me. Small particles behave differently in biological organisms. Before we go full-tilt into deploying new nano-scale materials into food products and anything else people might injest, maybe we should actually test these things and learn more about how they behave in biological organisms.

      --
      AccountKiller
    3. Re:Down with the Precautionary Principle! by Beryllium+Sphere(tm) · · Score: 1

      Calculated risk, or blind risk?

      Progress has to be an improvement over what came before. Mesothelioma, the result of one of our previous experiments with using materials, was not progress.

      New stuff needs to be tested. That's simply good engineering.

    4. Re:Down with the Precautionary Principle! by geekoid · · Score: 1

      The way we deal is through testing.

      --
      The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
    5. Re:Down with the Precautionary Principle! by Anonymous Coward · · Score: 0
      Progress requires risk. Deal.

      No, in fact progress does not require risk (except risk of financial, material or time loss). However, the greed, competitive rat race to be first and grab stinkin' "IP" for oneself does. One party "takes" risk (in fact, they expose all of us to risk along) to cut time short and reap the awards before others get there.

      I'd say: let them do whatever they want, provided they venture their own lives and all wealth on it. It is required because others are jeopardized who will not have equivalent rewards. Should their greed cause harm to those who wouldn't otherwise be harmed (and don't give me that "more lives saved" BS, you can not sacrifice others for each other without their consent!), responsible persons should be executed and their property confiscated.
  23. You're ignoring the "high surface area" part. by CyberLord+Seven · · Score: 1
    Yes, it's true. There are naturally occuring particles that are extremely small. In fact this reminds me of a photograph I saw once of a mite or other small insect that was on the leg of a flea. There was a caption about how something as small and bothersome as a flea had it's own pest.

    OK, I'm through digressing. Back to the point.

    Andrew Maynard is concerned that "very, very fine particles with high surface area, lead to a greater inflammatory response...". (emphasis mine)

    --
    We have always been at war with Eurasia!
    1. Re:You're ignoring the "high surface area" part. by Anonymous Coward · · Score: 0
      Idiot. All "very fine particles" have "high surface area", it can be proved mathematically.

      You misquoted the guy. The exact quote is
      very, very fine particles, particles with high surface area, lead to a greater inflammatory response
      (emphasis mine) Open your English textbook, the sementic meaning of "A,B,C" is "A (therefore B), C", not "A and B, C".
  24. Two edged sword by stox · · Score: 2, Insightful

    For precisely the same reason that nano sized particles will be revolutionary to the world of pharmaceuticals, they may prove to be toxic in other applications.

    --
    "To those who are overly cautious, everything is impossible. "
  25. Re:Off-topic... by diersing · · Score: 1
    Where is the experimental undo threading button once you click & and collapse a thread?

    I for one welcome our experimental threading overlords!

  26. Scale matters by macklin01 · · Score: 5, Insightful

    Nature is replete with examples where scale matters. Insect-scale airfoils don't work particularly well. Jumbo jet-scale insects wouldn't fly, either. At the molecular level, flagella give great propulsion in fluids, but the same wouldn't hold at the macroscopic level.

    The same is true in biology. I remember having read a study done at NASA on the effect of iron nanoparticles in lungs. (Alas, I can't seem to find the link anymore.) They concluded that at the nano scale, the iron particles could escape the normal protections and remain in the lungs (in the interstitium and cells themselves), where they could collect and have a toxic effect, including diminished lung function. (The test rats became lethargic, etc.) All this at exposure levels that wouldn't be considered toxic at other scales.

    I've seen similar research on sunscreen. Zinc oxide particles are great protecting at UVA and UVB. However, at large scale, they're quite visible and hard to blend in. Make them smaller, and that problem goes away, but they get absorbed deeper into the skin. Make them smaller still, and it's quite possible that they'll be absorbed into the cells themselves, leading to new potential health effects. (e.g., does zinc oxide become carcinogenic when they remain in the cells for too long? Does the motion into the cells increase the likelihood of reactive oxygen species (free radicals) accumlating inside the cells, rather than outside?)

    I'm not a biochemist or a biologist (I'm a biomathematician), so I don't have the answers to these questions. But it's clear that scale really does matter, and it needs to be considered. Is the danger overhyped? Possibly, or maybe not. That's why it needs to be studied. But it's going to be important to understand these effects when we move from the low levels that occur naturally to the high levels that will occur in human-made materials and products. -- Paul

    --
    OpenSource.MathCancer.org: open source comp bio
    1. Re:Scale matters by Anonymous Coward · · Score: 0

      Here's a link that has the type of thing that I had in mind. I still can't find the iron studies I remember, but the carbon and silica studies are similar.

    2. Re:Scale matters by bradbury · · Score: 3, Informative

      Generally speaking you have to be very careful about the precise material as well as its size. Iron and copper ions for example can be very toxic due to their ability to contribute to the production of free radicals (which will damage proteins and DNA). Zinc ions on the other hand are essential and play important roles in the structure of all zinc finger regulatory proteins. Organisms have protein systems that control the transport and storage of iron and copper ions to a much greater extent than zinc ions.

      Now it seems likely that metal oxides, being noncharged, are less likely to be involved in chemical reactions (its usually very hard to get oxides to interact at all). So I would expect zinc oxide (in contrast to iron particles) to be relatively benign. The question becomes whether the body has effective mechanisms for binding to and either degrading or removing nanoparticles. If it does not then exposure is potentially cumulative and may be harmful. The normal reaction of the body to something it cannot degrade or remove is to form a granuloma (a collection of cells designed to isolate the problem) surrounding it. So depending on the precise size of the particles they might either penetrate cell membranes and accumulate within cells (which is probably not good) or potentially accumulate until the point where granulomas may form. On the skin surface that isn't bad since you are sheding the skin anyway. Within the lungs however it can be a much larger problem (as silicosis and black lung disease show).

      Nanoparticles are not new -- coal miners, blacksmiths and cooks have been dealing with them for centuries. What may be new is greater exposure to a larger variety of nanoparticles by a greater fraction of the population. That is worth being careful about but does not translate into throwing out the baby with the bathwater.

    3. Re:Scale matters by Anonymous Coward · · Score: 0
      Nature is replete with examples where scale matters.
      Damn it! Now you're sounding just like my ex-girlfriend.
    4. Re:Scale matters by Anonymous Coward · · Score: 0
      I'm not a biochemist or a biologist (I'm a biomathematician), so I don't have the answers to these questions.

       
      Through my own studies of "biomathematics" I've found that by taking off my shoes I can be TWICE as effective!

        Hmmm, curious: The "captcha" for my post was "micros" -- shouldn't that have been "nanos" for this thread?
  27. Re:Off-topic... by udderly · · Score: 1

    BWAHAHA...SNOOOOOORT!!! Cough, cough, cough.

    What is that you ask? The sound of a Diet Code Red Mountain Dew going through my nose and onto my keyboard.

    Thanks a lot.

  28. Michael Crichton's Book by s31523 · · Score: 0, Flamebait

    This is very erie... Anyone read Prey by Michael Crichton? I think the developers of this nanotechnology should read this before proceeding. Interestingly, the bibliography of this book is quite extensive...

    1. Re:Michael Crichton's Book by A+beautiful+mind · · Score: 3, Insightful

      Noone should read Michael Crichton and base scientific policy on it, most importantly because what he writes is fiction. It may a good thing for provoking some thoughts, but nothing else. Scientists taking advice from him? I would think we would know better than that to propose such thing especially after his State of Fear (the book where he portrays global warming/climate change as fud making terrorists).

      I wouldn't take even Asimov novells as anything to be read if I would want to do science in a particular field. Fiction!=Science, no matter how good fiction it is.

      --
      It takes a man to suffer ignorance and smile
      Be yourself no matter what they say
    2. Re:Michael Crichton's Book by mooingyak · · Score: 2, Funny

      Personally, I'm a good deal more worried about being eaten by DINOSAURS!

      --
      William of Ockham had no beard. The most likely explanation is that it was chewed off by squirrels every morning.
    3. Re:Michael Crichton's Book by mblase · · Score: 3, Informative

      This is very erie... Anyone read Prey by Michael Crichton?

      Yeah, it was replete with pseudoscience that would make a great movie, but terrible research. Nanobots that are as intelligent, sophisticated, and above all mobile as the ones in that story aren't just impossible under current technology limits, they're impossible at all.

      Sixty years ago, tech enthusiasts were absolutely certain we'd have a colony base on the Moon by now. Sixty years from now, nanotech will be just as stunted compared to where we imagine we'll be.

    4. Re:Michael Crichton's Book by freeweed · · Score: 1

      Why on earth isn't this at least modded up Funny?

      Using Prey as a reason to be concerned about nanotech research makes about as much sense as using Jurassic Park as a reason to be concerned about the Human Genome Project.

      --
      Endless arguments over trivial contradictions in books written by ignorant savages to explain thunder in the dark.
    5. Re:Michael Crichton's Book by edwardpickman · · Score: 1

      Hate to say it but you can get more hard science out of a Hitch Hikers Guide book. Prey wasn't exactly one of Crichton best. The premise was silly and had been done countless times before in lame low budget scifi films. The grey goo senario is interesting but a little too extreme. I'm more concerned with cancer and genetic damage. Otherwise inert materials can be highly reactive on a Nano level. A lot of the materials exist in nature but in tiny trace amounts. In high concentrations it's hard to say what reaction they will have on the human body and the environment. Since they do react differently our current regulations are woefully inadequate to regulate their use. In a sense we're in the same position with nano particles that we were in with the birth of industrialization. Remember lead and mercury were extremely common and even used in medicines. False teeth used lead. In Roman times they used lead for water pipes. They simply didn't know better. The potential for good is extreme but so is the potential for harm. Better to use some common sense and do the testing before the materials are used then find out an explosion in the cancer rate is the result of heavy use of nanoparticles. We can live without them so the bigger concern is can we live with them? I grew up when asbestos was common and all white paint had lead in it. You'd never consider using ceiling tiles with asbestos in them today but they used to be common. They put asbestos in cigarette filters for Christsake. You don't have to be paranoid to want some caution. History shows there's a good chance that some of the materials will prove hazardous to health. Corporations aren't very responsible and they have a bad habit of releasing products and dealing with the lawsuits later.

    6. Re:Michael Crichton's Book by newt0311 · · Score: 1
      I don't have a problem with the nanobots being intelligent and sphisticated (though I think they will get there pretty once quickly once the manufacturing problem is solved) but I have a major problem with the mobile part.

      Take a nanotube. then take another smaller nanotube and slide the smaller one inside the larger one. then attach the sensor chemical found in eyes as a hinge between the two. when hit by a photon, the molecule gets a 90 degree bend in femtoseconds. If you just keep hitting it with photons, you can make a sliding device to propel anything on top of the nanotubes across at over 100 m/s. And yes, people have already managed to make working models in labs. movement is not a problem for nanobots.

  29. No Problem by javaxjb · · Score: 1

    Just call Wesley, he'll crush them.

    --
    Programmers in mirror are brighter than they appear
    1. Re:No Problem by Anonymous Coward · · Score: 0

      ahahhaha nice TNG referance; we're safe so long as the dont make sweet nano love

  30. Uh... that's f*cked up. by neo · · Score: 5, Interesting

    I played a thought experiment with a very smart fellow. The goal of the experiment was to come up with a safe way to create self replicating nanites that could cure cancer. We had 1 nanite that would cure cancer, but it was, of course, slow. The goal was to create enough to heal an entire body.

    So the best way to make more nanites is to have the nanites make more of themselves. Seems pretty straight forward... only everytime we go about doing it we run into this little problem.

    Mutations.

    So we build these guys to start replicating and to stop replicating when we want them to... but when you make a billion of something you end up with some odd mutations. Even if you are talking about .001% mutation that's still 100,000 self replicating mistakes. If even one of those 100,000 mistakes is a mutation that just doesn't turn off self replication you now have a very bad problem.

    Released, this nanite could theoretically convert the earth (see "grey goo") into a giant ball of itself.

    Now I know this thread is going to be long, because so many of you very smart people will have so many smart ideas about how to make this safe. I'm glad you have these ideas and I'm glad you're voicing them. Some of them might even work.

    What scares the hell out of me is that you're not the people working on this.

    1. Re:Uh... that's f*cked up. by Anonymous Coward · · Score: 0

      A non-perfect replicator that makes non-perfect copies of itself may become subject to natural selection. Hence evolution.

      The early Earth was in some ways a ball of green-goo, it still is today.

      I think caution should be taking when (or if) we ever get to the point of nano-fabricators and replicators, but by no means should it be forbidden! This technology would bring humanity into a new age.

    2. Re:Uh... that's f*cked up. by Beryllium+Sphere(tm) · · Score: 2, Insightful

      A few dozen independent mechanisms that run a checksum and which work at different points in the process to prevent reproduction, sabotage reproduction, make the mutants non-viable, make the second generation sterile, etc.

      The problem is you'll probably find out that in order to keep up with rapidly mutating and adapting cancer cells, the nanites will *need* to mutate.

    3. Re:Uh... that's f*cked up. by ceoyoyo · · Score: 1

      Yup, self replicating minature machines will definitely convert the world into themselves. Wait... we've had self replicating minature machines around for a couple billion years and they haven't done it yet. Hm.

    4. Re:Uh... that's f*cked up. by dsanfte · · Score: 1

      Cancer cells usually have a single, or perhaps two or three mutations that render them malignant. They are not mutating as often as something like AIDS (which mutates often, but not as rapidly as many think).

      Indeed, were the cancer cells mutating as fast as you suggest, we wouldn't need to treat cancer; the cancer cells would eventually mutate so much so as to be unable to duplicate their chromosomes anymore, and all cancers would be self-containing. That isn't what happens, obviously.

      Nanites don't need to mutate. A single sampling of the genome of the cancer can be taken, the mutations found (as compared to normal cells), and then they will be programmed. And it will work.

      --
      occultae nullus est respectus musicae - originally a Greek proverb
    5. Re:Uh... that's f*cked up. by FleaPlus · · Score: 1

      So we build these guys to start replicating and to stop replicating when we want them to... but when you make a billion of something you end up with some odd mutations. Even if you are talking about .001% mutation that's still 100,000 self replicating mistakes. If even one of those 100,000 mistakes is a mutation that just doesn't turn off self replication you now have a very bad problem.

      Released, this nanite could theoretically convert the earth (see "grey goo") into a giant ball of itself.


      Much the same logic could apply to cancer cells themselves, as they're self-replicating and mutate. Why isn't the world a giant ball of cancer cells?

    6. Re:Uh... that's f*cked up. by xappax · · Score: 2, Interesting

      Your point that nanotech is a high-stakes business is well taken. Just as with biotech, we should not give in too easily to the temptation and excitement of new possibilities before we have evaluated the dangers and genuinely checked our assumptions.

      However, in the spirit of brainstorming, it seems that if you create enough redundant and functionally diverse systems in the nanomachine to check itself out, and then destroy itself if it didn't check out correctly - mutations would become statistically impossible. A single bot being assembled in which all 15 self-validation/autodestruct mechanisms are broken is incredibly unlikely, even considering the number of mutations, and all that's needed is for one mechanism to function correctly to eliminate the problem.

      Still, though - at this point we're talking about programming, and everyone knows that with programming comes bugs, one of the most common being the infinite loop, coincidentally :)

    7. Re:Uh... that's f*cked up. by DamnStupidElf · · Score: 2, Interesting

      So we build these guys to start replicating and to stop replicating when we want them to... but when you make a billion of something you end up with some odd mutations. Even if you are talking about .001% mutation that's still 100,000 self replicating mistakes. If even one of those 100,000 mistakes is a mutation that just doesn't turn off self replication you now have a very bad problem.

      First of all, self replication should only be attempted after many years of successful nanotechnology, if at all. It's much safer to have two or more types of nanobots that can produce only the next type in a cycle, but not themselves. This lowers the probability of run away replication, because any point in the chain can be disabled. Having choke-points or environmental controls on reproduction is also a good idea.

      Probably the single biggest safety measure for individual nanobots is lots of redundancy and cross checking. Every nanobot should be a collection of independant modules, all of which must cooperate in order to complete any task. Additionally, each module should be able to trigger a shutdown of the entire nanobot if inconsistancies arise. Self repair should be avoided at all costs because it is much safer for working nanobots to disassemble the broken ones and build new ones than to allow random changes to evolve within a self repairing and self replicating system. Cryptography will probably also play a large part, because traditional error checking will not be adequate to detect every error in trillions of nanobots, each executing trillions of instructions a second. Additionally, encrypting communication between modules and even instructions and data in memory will serve as protection against intelligent hacking attempts at modifying the internal state of the nanobots.

      As part of the redundancy, it makes a lot of sense not to have truly autonomous nanobots, but instead require the environment to supply them with critical components, energy, or control without which they cannot function. It's much harder to make grey goo if every nanobot requires a complex chemical to operate that doesn't occur in nature and cannot be produced by the nanobot, especially if that chemical is what provides its energy to operate.

      Evolution should never be allowed in the design of complete nanobots. Components can be evolved to be maximally efficient, but the overall structure and controls must be rigorously verified to ensure safe operation.

      Just as aside, the grey goo scenario has already happened at least once on Earth. It's just more of a greenish goo, with some collections of larger un-goo-like structures.

    8. Re:Uh... that's f*cked up. by Damastus+the+WizLiz · · Score: 1

      But they did. Most of the earth is covered with cells.

      --
      I often have trouble remembering which way is out of bed in the morning.
    9. Re:Uh... that's f*cked up. by ceoyoyo · · Score: 1

      Just the outer layer. It's not a ball of cells. It seems to have made it a more interesting place too.

    10. Re:Uh... that's f*cked up. by Alef · · Score: 1
      The goal of the experiment was to come up with a safe way to create self replicating nanites that could cure cancer. [...] So we build these guys to start replicating and to stop replicating when we want them to... but when you make a billion of something you end up with some odd mutations. Even if you are talking about .001% mutation that's still 100,000 self replicating mistakes. If even one of those 100,000 mistakes is a mutation that just doesn't turn off self replication you now have a very bad problem.

      Actually, that is essentially what cancer is, except then it is one of the human cells that replicates in an uncontrolled manner. So you would have recreated the problem you set out to solve, except with nanites instead of human cells.

      Presumably, there is much to learn from studying cancer and how the human body deals with cell mutations, before one starts designing self replicating nanites. Of course, that presents a catch 22 in your thought experiment.

    11. Re:Uh... that's f*cked up. by newt0311 · · Score: 1
      First of all, self replication should only be attempted after many years of successful nanotechnology, if at all. It's much safer to have two or more types of nanobots that can produce only the next type in a cycle, but not themselves. This lowers the probability of run away replication, because any point in the chain can be disabled. Having choke-points or environmental controls on reproduction is also a good idea.
      Without self-replication, nanobots will get absolutely nowhere. Using current tech, it takes ~ 40 years to build a functional nanobot (it needs to be done atom by atom). The only practical way of changing this is to get some microscopic workers in to help speed the work along in an exponential fashion, thus nanobots making more of themselves.

      Probably the single biggest safety measure for individual nanobots is lots of redundancy and cross checking. Every nanobot should be a collection of independant modules, all of which must cooperate in order to complete any task. Additionally, each module should be able to trigger a shutdown of the entire nanobot if inconsistancies arise. Self repair should be avoided at all costs because it is much safer for working nanobots to disassemble the broken ones and build new ones than to allow random changes to evolve within a self repairing and self replicating system. Cryptography will probably also play a large part, because traditional error checking will not be adequate to detect every error in trillions of nanobots, each executing trillions of instructions a second. Additionally, encrypting communication between modules and even instructions and data in memory will serve as protection against intelligent hacking attempts at modifying the internal state of the nanobots.
      Are you sure that you are not just being overly paranoid. Nanobots are not some disgruntled slaves just looking for an opportunity to rebel. Also, note that these things do not have much in the way of mass (think just a few million atoms at most), forget processing power. you want these things to run AES on themselves??? So what is one nanite out of a hundred gets a bug, it probably won't last long anyway. also note that nanobots are delicate systems and it takes a lot of effort to get even theoretical ones which work. Having one which could work after getting a mutation would probably the the engineer who designed it the equivalent of a nobel prize.

      As part of the redundancy, it makes a lot of sense not to have truly autonomous nanobots, but instead require the environment to supply them with critical components, energy, or control without which they cannot function. It's much harder to make grey goo if every nanobot requires a complex chemical to operate that doesn't occur in nature and cannot be produced by the nanobot, especially if that chemical is what provides its energy to operate.

      Evolution should never be allowed in the design of complete nanobots. Components can be evolved to be maximally efficient, but the overall structure and controls must be rigorously verified to ensure safe operation.

      First of, removing autonomy defeats their purpose to a large extent. it is not really possible to use these things effectively if you have to keep them in a tank of exotic chemicals just to keep them from falling apart. Evolution probably won't come into the design of these things even if we wanted it to be there. refer to my previous point about mutation in these things.

      Repeat after me until it sinks into your head: Nanobots are not out to kill me. Nanobots are not out to kill me. Nanobots are not out to kill me.

    12. Re:Uh... that's f*cked up. by DamnStupidElf · · Score: 2, Interesting

      Without self-replication, nanobots will get absolutely nowhere. Using current tech, it takes ~ 40 years to build a functional nanobot (it needs to be done atom by atom). The only practical way of changing this is to get some microscopic workers in to help speed the work along in an exponential fashion, thus nanobots making more of themselves.

      Read what I wrote. Making individual nanobots capable of replicating themselves is a mistake. Allowing nanobot model A to build nanobot model B, and model B to build model A is much different. You have have the chance of a runaway scenario if you make the control channel for each nanobot separate. Keeping nanobots A and B mostly separate from each other is even more secure.

      Are you sure that you are not just being overly paranoid. Nanobots are not some disgruntled slaves just looking for an opportunity to rebel. Also, note that these things do not have much in the way of mass (think just a few million atoms at most), forget processing power. you want these things to run AES on themselves??? So what is one nanite out of a hundred gets a bug, it probably won't last long anyway. also note that nanobots are delicate systems and it takes a lot of effort to get even theoretical ones which work. Having one which could work after getting a mutation would probably the the engineer who designed it the equivalent of a nobel prize.

      Most likely to be of much use nanobots will need at least as much processing power as current desktop PCs, probably more. Even if they are totally headless and controlled via wireless it makes sense to encrypt the communications channel and make the nanobot shut itself down in case of a fault. Don't forget that not only are random mutations a concern, but also intelligent hackers trying to make the nanobots do things they weren't supposed to do, perhaps using other nanobots. The reason self repair is dangerous is that it involves autonomous self modification, which introduces more possibilities for undetected errors in operation. For instance, the worst case is when sensors fail, causing the nanobot to believe something is broken when it's not. This leads to what the nanobot believes to be valid repairs which actually introduce unwanted behavior. In terms of pure numbers, *eventually* humanity is likely to produce more nanobots than there are biological cells. At that point, evolution is clearly a concern.

      First of, removing autonomy defeats their purpose to a large extent. it is not really possible to use these things effectively if you have to keep them in a tank of exotic chemicals just to keep them from falling apart. Evolution probably won't come into the design of these things even if we wanted it to be there. refer to my previous point about mutation in these things.

      Modern medicines are basically just complex chemicals but can be injected into the bloodstream. It's not hard to create inert chemicals that could be used as the signaling device for nanobots in the human body.

      Repeat after me until it sinks into your head: Nanobots are not out to kill me. Nanobots are not out to kill me. Nanobots are not out to kill me.

      Neither are viruses, bacteria, or prions, they're just reproducing and mutating like nature intended. The side effect is that sometimes they kill us.

  31. Poor logic.. by Vellmont · · Score: 5, Insightful

    So essentially your argument is:

    There exists some molecules that already enter the blood-brain barrier without problems. Therefor all molecules entering the blood-brain barrier have no problems. One could prove anything (including known falsehoods) using that kind of logic.

    What I read in the article was that when we create very very fine particles out of substances they behave differently in biological organisms than they do when they aren't in very very small particles. We really have no information on how these very fine particles might behave in biological organisms, so we really should be more cautious in including them in food products, or anything else people might injest since they really haven't been tested yet.

    --
    AccountKiller
    1. Re:Poor logic.. by geekoid · · Score: 2, Interesting

      "Whenever I hear the word activist, I reach for my revolver."
      The founding fathers were activists. As was Any of many people that caused changes.

      Just thought you might like to know that.

      --
      The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
    2. Re:Poor logic.. by Vellmont · · Score: 1


      The founding fathers were activists. As was Any of many people that caused changes.

      Funny, I don't recall any of them referring to themselves as activists, or mentioning that word in writing. Thus no revolver-reaching-for.

      --
      AccountKiller
    3. Re:Poor logic.. by Anonymous Coward · · Score: 0

      Besides, they are all dead already and it happened before revolver was invented!

  32. Ooooh scary. by asciimonster · · Score: 0

    I thought that people investigated BECAUSE the body responded diffentently on nanotechnological materials. And also BECAUSE materials combined and shaped in unusual ways got unusual results.

    P.S. The nanotechnology hype is over. It has been for some time now. All nanotech products I've seen so far is an anti-fog, anti-rain spray for your cars widscreen. Just like the dot-com bubble it didn't live up to the high expectations that (mostly American) scientists created.

    1. Re:Ooooh scary. by geekoid · · Score: 1

      no it's not, nano-tech as we talked about 10 years ago is completely different then what they call nanotech today.

      --
      The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
    2. Re:Ooooh scary. by jd420 · · Score: 1
      P.S. The nanotechnology hype is over. It has been for some time now. All nanotech products I've seen so far is an anti-fog, anti-rain spray for your cars widscreen. Just like the dot-com bubble it didn't live up to the high expectations that (mostly American) scientists created.
      ...and yet, neither programming nor factory automation stand quite fully "left behind in the mists of time."

      You're right, though, in that it's (IMO) a very apt comparison - a very useful field being shat upon by hype injected by those unscrupulous souls outright-embezzling from whatever venture capitalist didn't have a clue what they were talking about - and ever since about 2-3 years ago with the media promotional influx, what people referred to as "nanotech" suddenly became "crap that didn't meet much of the criteria of nanotech."

      ...but, like the dot-com, that doesn't mean that nanotech is anywhere NEAR dead, far from it - just that the real thing is at risk of being hurt when a useless hype bubble finally pops.
  33. Re:Off-topic... by brunascle · · Score: 1
    Where is the experimental undo threading button once you click & and collapse a thread?
    it seems to be "Two"... no wait... they all do the same thing...

    the bloody hell?

    am i the only one starting to suspect this is a psychological "experiment", rather than a technical one?
  34. Basic physics... by Vellmont · · Score: 2, Insightful


    Released, this nanite could theoretically convert the earth (see "grey goo") into a giant ball of itself.

    There's this little problem with replication called "energy", and the laws of thermodynamics. Making order out of disorder requires energy to be expended. Exactly where is all the energy going to come from to turn everything into "grey goo"?

    --
    AccountKiller
    1. Re:Basic physics... by mikiN · · Score: 1

      Exactly where is all the energy going to come from to turn everything into "grey goo"?

      Well, there's this great ball of fire up in the sky. Plants and some other critters with chlorophyll use it to create carbohydrates out of thin air (think CO2) and water. Also, there's a big furnace burning below ground, enough to supply the activation energy for many chemical reactions. Not exactly nano stuff, but just imagine hooking up nano and bio together (they're working on that) and yes, I think you could have your 'grey goo' alright...
      Other prime candidates for the stuff are generically engineered bacteria (think about 'oil-eating' bacteria running amok) and viruses (think about an Ebola from Hell that attacks all living things).

      The key factor in all of this is the K factor. Same as with nuclear chain reactions, when K > 1 you get a chain reaction. When there is enough source material and you cannot control it so K becomes < 1 again, it just keeps on going. This is what we have to worry about in all these scenarios.

      --
      The Hacker's Guide To The Kernel: Don't panic()!
    2. Re:Basic physics... by zolaar · · Score: 1

      The human body generates more bioelectricity than a 120 V battery and over 25,000 BTU's of body heat. Combined with a form of fusion the machines had found all the energy they would ever need...

      --
      One man's constant is another man's variable.
    3. Re:Basic physics... by Vellmont · · Score: 2, Insightful


      Plants and some other critters with chlorophyll use it to create carbohydrates out of thin air (think CO2) and water.

      Exactly. And have said plants managed to convert the earth into "grey goo" yet? They've had quite a while to get really good at being efficient at using energy and matter to make themselves.


      there's a big furnace burning below ground, enough to supply the activation energy for many chemical reactions

      Ok, and once all the chemical reactions have taken place that were activated by the higher temperatures, where does the energy come from?

      The point is that simply making alarming statements about "grey goo" and runaway reactions without understanding the limiting components is silly. Any organism requires the raw materials required to build it (which atoms do you need), and the energy required to do it. If you need a bunch of iron atoms, sodium atoms, or whatever and you run out, well the replication thing is going to die out.

      --
      AccountKiller
    4. Re:Basic physics... by joto · · Score: 1

      blockquote>Exactly. And have said plants managed to convert the earth into "grey goo" yet? They've had quite a while to get really good at being efficient at using energy and matter to make themselves.

      Pretty much, yes. You won't find many places on the planet, where plant-life can grow, but there is no plant-life there.

      The point is that simply making alarming statements about "grey goo" and runaway reactions without understanding the limiting components is silly. Any organism requires the raw materials required to build it (which atoms do you need), and the energy required to do it. If you need a bunch of iron atoms, sodium atoms, or whatever and you run out, well the replication thing is going to die out.

      This doesn't mean that it won't cause problems. It may end up killing all life on the planet, or something like that, before it stops.

    5. Re:Basic physics... by Vellmont · · Score: 1


      This doesn't mean that it won't cause problems. It may end up killing all life on the planet, or something like that, before it stops.

      I find this a rather meaningless statement. You can make a lot of potentially true, but useless statements about something that isn't defined and doesn't actually exist. Since we know nothing about this thing that doesn't exist, we can make almost an infinite amount of meaningless statements about what it MIGHT do. The only limits we can place upon it are the physical bounds of reality. Essentially the less you know about something, the more possibilities of what it MIGHT do there are.

      The trick is, don't mistake our ignorance of something for actual knowledge.

      --
      AccountKiller
    6. Re:Basic physics... by mikiN · · Score: 1

      Essentially the less you know about something, the more possibilities of what it MIGHT do there are.

      Exactly. That is why I made the point about the K factor. If all you know about a process is the fact that it might 'run away', this should be a fair warning not to mess with it without a controlled environment.

      It doesn't really matter what else you know about the process, the risk of (currently) unknown and irreversible damage from runaway processes remains. There are enough examples to prove that, ranging in scale from the introduction of rabbits in Australia (we're never going to get rid of them again) to depletion of the ozone layer (we're lucky we have stopped manufacturing CFCs and haven't 'engineered' a self-replicating CFC-releasing agent yet) all the way to (replicating) prions in the food chain to computer viruses in relation to strong AI (yeah, keep those 'SkyNet became aware today' jokes coming).

      --
      The Hacker's Guide To The Kernel: Don't panic()!
    7. Re:Basic physics... by namespan · · Score: 1

      Exactly. And have said plants managed to convert the earth into "grey goo" yet? They've had quite a while to get really good at being efficient at using energy and matter to make themselves.

      Evolution's fantastic and all, but it's hardly an exhaustive search of all the possibilities at an scale. People have been able to invent lots of interesting and efficient things that haven't evolved, from wheeled carts to nuclear weapons. Self-replicating nanomachines will face limitations, but it's no reason to get complacent.

      --
      Libertarianism is rich wolves and poor sheep playing gambler's ruin for dinner.
  35. Re:Off-topic... by AcidLacedPenguiN · · Score: 1

    you can get that in diet??? Man I miss code red. . .

    --
    disclaimer: I've been known to store numbers in my ass for which to dig out when quantities are required.
  36. ohnoes! by Anonymous Coward · · Score: 0


    it's a very very small trap!

  37. Nanopathologies by Anonymous Coward · · Score: 0

    There are 2 researchers, in particular, who are studying the effects of nanoparticles on human body: Stefano Montanari and Antonietta Gatti. They showed, among various human tissues "contaminated" by nanoparticles, that nanoparticles could invade sperm, the lymphatic system and even penetrate the cell nucleus.

    Unfortunately they're not widely known, as their work, outside Italy.

    If you can understand Italian try to read here:

    http://www.nanodiagnostics.it/
    http://it.wikipedia.org/wiki/Nanopatologia

  38. seriously... by Anonymous Coward · · Score: 0

    the fact that nanotech is here to stay and corporate fat cats will all be stampeding like cattle to market this stuff when it comes of age, with no thought for safety concerns, only PROFIT; it behooves geekdom to apply pressure for researching nanotech on human health NOW, before the horse breaks out of the stable and we're stuck dealing with the health issues after the fact...ass backwards, like usual.

    sorry for the run on sentence.

  39. MGS by DanielNS84 · · Score: 1

    This is true...I hear Solid Snake never fully recovered...

  40. "Nice?" by Rob+T+Firefly · · Score: 3, Insightful

    I don't think that word means what you think it means.

  41. Huh? ... another BigChicken by OldHawk777 · · Score: 2, Insightful

    I remember the 1950s, sounds like the atomic bomb again, radiation poising, evil mad science, nature-gone-wild ... sounds like more B-grade scifi movies are on their way, or the new-conservative plutocrats are justified in keep everyone from behaving responsibly by not having a gun, stem-cell, nuke .... NanNO Borg the monster was a human infected by terrorist spread necrotic-nano-bots from Mars.

    If we are going to destroy our species, I wish would just get it done. Anything is better than accepting domination by fear-mongering idiots in charge (Neo-Nazi, Neoconservative, Neo/Pseudo-Christian/Moslem/Jew ...) who are continually gucken up the world for humanity.

    Give me liberty, or give me death, from the all KnowWhatsBestForYou powerful of this world.

    --
    Unaccountable leaders are masters, and unrepresented people are slaves. How do US and EU fare?
    1. Re:Huh? ... another BigChicken by mikiN · · Score: 1

      Neo-who?

      Neo = One. You, Me, Everybody.

      He said it best. The problem is Choice.

      --
      The Hacker's Guide To The Kernel: Don't panic()!
    2. Re:Huh? ... another BigChicken by OldHawk777 · · Score: 1

      When they behave as one ... they are one ....

      --
      Unaccountable leaders are masters, and unrepresented people are slaves. How do US and EU fare?
  42. One Man's Assertions... by clang_jangle · · Score: 2, Informative

    ...doth not an article make. Won't someone PLEASE think of the *science* ?!

    --
    Caveat Utilitor
  43. Like asbestos? by ribuck · · Score: 1

    Consider asbestos: it's harmless in a large piece. But once that piece starts crumbling, asbestos tends to split lengthwise into thinner and thinner fibers (rather than shorter and shorter ones). Breathe those in and you might end up dying an agonising death.

    So yes, we do need to study nanoeffects of materials, even when we already know the bulk effects of those same materials.

    The interview in TFA is a bit non-committal, but one very good point was made: a set of "best practises" should be drawn up to help bridge the gap between today's exploration of the possibilities of nanotechnology - and the hindsight that will surely come in the future.

  44. Re:Off-topic... by diersing · · Score: 1

    We are at war with Euroasia, we've always been at war with Euroasia.

  45. Re:Scale matters, and so does hype by NorbrookC · · Score: 4, Insightful

    Is the danger overhyped? Possibly, or maybe not. That's why it needs to be studied.

    I'm old enough to remember something very similar to this back when gene splicing first became practical. Recombinant technology had a lot of hype around its promise, while at the same time there was an equal amount of hype about its dangers. Depending on which "expert" you were listening to, it was either going to solve all our problems or wipe humanity off the planet.

    The compromise was to put stringent safeguards on it. Twenty years later, we can look back and see that a lot of them were unnecessary, and that much of the hype was overblown on both sides. I think we're going to see something similar arising from nanotechnology. Yes, there's a lot of promise, and yes, there are some dangers. Until we better understand the technology, it's better to put in some safeguards, with the idea in mind that we can always relax them or tighten them.

    It's always instructive to look back, and to take some lessons from the past. Banning a technology outright because of fear doesn't work. Someone will eventually use it. At the same time, embracing a technology unreservedly also doesn't work. There are many examples of it blowing up in someone's face after-the-fact. It's not anti-technology to be aware of potential dangers and to take steps to mitigate them as you move forward. But neither should the dangers prevent you from moving forward.

  46. Re:Off-topic... by celardore · · Score: 1
    it seems to be "Two"... no wait... they all do the same thing...
    What about two and two? Oh wait there's no five option.
  47. Re:Scale matters, and so does hype by radtea · · Score: 4, Informative

    I'm old enough to remember something very similar to this back when gene splicing first became practical. Recombinant technology had a lot of hype around its promise, while at the same time there was an equal amount of hype about its dangers.

    There was actually a voluntary suspension of recombinant DNA research for a short time back in the '70's. Everyone started doing it again when the truth became clear: recombination happens in nature all the time, and the mechanism was such that naturally occuring recombination was doing all the things that scientists wanted to do. Given this, it was felt there was little risk of uncontrolled side-effects. It is worth adding that this is different from believing that there is little risk (social, economic or environmental) from GMOs specifically designed to cause harm to others for the profit of some, like those containing Monsanto's Terminator gene.

    The situation with nanoparticles is a little more ambiguous. There was as story on /. today on carbon nanotubes in ancient steel, and of course the first discovery of exotic carbon allotropes was in smoke, which is not exactly a rare substance. This suggests that some forms of nanoparticles have been around in the environment for a long time. However, it does not follow from this that naturally occuring nanoparticles are similar to the ones we are trying to create. Some, like carbon nanotubes and buckyballs, are unlikely to cause harm. But given their ability to infiltrate the body's natural defenses there needs at least to be careful assessment of new nanosubstances before any are allowed to released into the environment.

    Nano-materials are nothing more than large molecules, after all, and you wouldn't want people releasing large amounts of potentially deadly substances into the environment in the fond hope that they won't harm anyone with sufficient money to sue.

    --
    Blasphemy is a human right. Blasphemophobia kills.
  48. Doesn't anyone want to see... by Anonymous Coward · · Score: 0

    ... my nano bits?

    OMG... never mind!

  49. We already know by Anonymous Coward · · Score: 0

    We already know this... as evidenced by this previous slashdot article... what could be more dangerous than a sward made of carbon nano tubes?

    http://science.slashdot.org/science/06/11/16/23482 54.shtml

  50. Re:Scale matters, and so does hype by ColdWetDog · · Score: 3, Interesting
    There was actually a voluntary suspension of recombinant DNA research for a short time back in the '70's. Everyone started doing it again when the truth became clear: recombination happens in nature all the time, and the mechanism was such that naturally occuring recombination was doing all the things that scientists wanted to do.

    And that's exactly the point - slow down cowboy until you have some idea of what you're doing. The recombinant DNA restrictions worked exactly as designed - people slowed down a bit and studied potential downsides, worked on mitigation strategies (P level confinement - now widely used on our War on Terrorism(R)(TM)(Patent Pending by Johnson's wax)).

    Hopefully real nanotechnology will turn out to be more than marketing and venture capital hype, but it behooves us to look at potential pitfalls as well as potential progress. Besides, you should be able to get some pretty good anti terrorism funding by doing that kind of research these days.

    --
    Faster! Faster! Faster would be better!
  51. ha by Anonymous Coward · · Score: 0

    I, for one, welcome our Go-Pants Nano-Technology Overlords.

  52. because I must . . . by Heisman · · Score: 1

    I, for one, welcome our brain infesting, body-controlling overlords with their carbon nanoswords. w00tz!

  53. how is this different from anything else? by Goldsmith · · Score: 1

    Nanoparticles and nanostructured materials have been around for a long, long time. Just last night, there was an article posted here on how carbon nanotubes were a key component of Damascus steel. Nanoparticles are produced in many natural chemical reactions, in all biological systems and any time something burns. My point is that simply being a nanoparticle does not make something dangerous.

    New materials, or old materials put to new uses should absolutely be tested for safety, whether that new material is a new pesticide or a new nanoparticle. I don't think there's any reason to treat nanostructured materials any different from a new drug, new pesticide or other such dangerous chemical.

  54. How to hurt people, in quantity, cost-effectively by handy_vandal · · Score: 2, Interesting

    a bomb that goes off and small (but not nano) pieces of jagged metal (let's call them 'shrapnel') get shot through your body at very high speed. pretty revolutionary, eh?

    Back in the eighties, a friend of mine quit a job (programmer) with a defense contractor, when he found out:

    (A) The firm was making cluster bombs ...

    (B) from dark-red plastic, because ...

    (C) plastic isn't revealed by x-rays, and red is hard for surgeons to see during surgery.

    The point was not to kill large numbers of people, but to injure large numbers of people in such a manner as to require lots of expensive medical personnel, thus winning the war by attrition.

    Immoral? That's a judgement call.

    Cost-effective? The defense contractor thought so.

    -kgj

    --
    -kgj
  55. Industrial Nanorobotics by SMACX+guy · · Score: 1

    Already we have turned all of our critical industries, all of our material resources, over to these ... things .. these lumps of silver and paste we call nanorobots. And now we propose to teach them intelligence?! What, pray tell, will we do when these little homunculi awaken one day and announce that they have no further need of us?

  56. Chemistry has always been dangerous. by Anonymous Coward · · Score: 1, Insightful
    Haven't we had nanotechnology for ages?


    Exactly

    Nanotech schmanotech. Chemistry is chemistry is chemistry. Engineers pretending to be chemists, bah!

    Don't believe me? Stick your finger in a container of 50% sodium hydroxide to see what happens, never mind that it is dissolving the glass container it is in... (a Teflon container will hold it)

    Or try ingesting 250-500 g (1-2 hits) of lysergic acid diethylamide and wait and see what happens when that gets to the brain... hehehe.

    This is not news. Chemistry has always been a dangerous field. One must be very well educated and aware to avoid injury or illness.

      "Nanotech" sounds cooler than chemistry so I guess it is news...
    1. Re:Chemistry has always been dangerous. by Anonymous Coward · · Score: 0
      Or try ingesting 250-500 g (1-2 hits) of lysergic acid diethylamide and wait and see what happens when that gets to the brain... hehehe.


      Make that 250-500 micrograms... it seems slashdot does not take well to the mu character (ALT-0181).
    2. Re:Chemistry has always been dangerous. by RobertLTux · · Score: 1

      i would think that ingesting even 25 grams (micro is-10^6?) would send you on a trip to Vallahalla (or whatever is apropriate)

      --
      Any person using FTFY or editing my postings agrees to a US$50.00 charge
  57. Nanotechnology != Nanoparticles by MrSteveSD · · Score: 1

    Some kinds of nano-particles may be dangerous but we shouldn't get the wrong impression that Nanotechnology is itself dangerous. Similarly, microscopic particles can be dangerous but we don't think of micro-scale technologies such as Microprocessors as being dangerous.

  58. I for one... by ssrs396 · · Score: 1

    ...welcome my position as your nano-overlord. When the nano powders don't catch fire during processing, they make great weapons. However, I make the weapons and only give them to my loyal minions. Now is a good time to swear loyalty.

  59. nano by H0D_G · · Score: 2, Informative

    as a student in a nanotech degree, I have to laugh at the conjectures here. all of these comments about "grey goo" and self replicating "nanites" are pure alarmism. Drexler himself doesn't believe it's possible. and as for all of this screaming about the control of nanomaterials, powder technologies are only a very small part of the whole nanotech research area. most of the research that I've come in to contact with has been focused not on powders but on surfaces and coatings, or biomedical sources, which is where all the money is and Prey is horribly bad. the situation described, as well as many of the properties attributed to nanomachines, is complete fiction. problem is, it's believeable to non-scientists. when talking about nanotechnolgy to non-scientists, I either get "what is that" or "you'll kill us all, grey goo." it's actually a damaging book, in that it actively attempts to hobble a science before it was anywhere near that level of complexity.

    --
    Kids! Bringing about Armageddon can be dangerous. Do not attempt it in your home!
  60. Reply: Basic physics... by OldHawk777 · · Score: 1

    I agree, only a known can be addressed/controlled/manipulated, and fear of the unknown can cause a potentially catastrophic unknown. I feel, that many Luddite and/or religious leaders create a far greater potential to cause the extinction of the human species, then anything theoretical/applied mathematicians, scientist, engineers ... may do accidentally and/or in an uncontrolled environment.

    IOW, curiosity killed the cat, while a lack or repression of human curiosity will destroy everything that humans are and will be.

    --
    Unaccountable leaders are masters, and unrepresented people are slaves. How do US and EU fare?
  61. I lolz'd MFAO. by jd420 · · Score: 1
    ...nanotechnological engineering and nanorobotics - the real thing, damnit - is one of my hobbies... ...which makes all the bullshit surrounding it somewhere along the lines of "mothafukin' hilarious."

    The first thing to keep in mind is that - due to the amount of hype being poured and finaced into this little bubble-about-to-burst-once-it-gets-its-financial-b ackers - most of what random talking heads call "nanotechnology" doesn't meet a hobbyist's minimal criteria. ...for example...

    "We know from animal studies that very, very fine particles, particles with high surface area, lead to a greater inflammatory response than the same amount of larger particles."

    Translation : "I chopped a line of meth a little finer than usual before coming out here, and it burned more."

    See - precipitating a statistically-monomolecular crystal is an old, old chemists parlor trick, used mostly for either amusement - "yes, this small brooch has, statistically, exactly ONE molecule of sapphire under the plastic! Just one, not more, not less!"... ...or, as the author notes in his "meth-related burn" schtick - for faster absorbtion.

    This is no more "1337 n4n0t3k" any more than "HTML-without-even-jscript" qualifies as "I r ur h4x0r g0d."

    We also know that they can enter the lining of the lungs and get through to the blood and enter other organs.


    Read : "After snorting finely-powdered meth, I then proceeded to vaporize a little crack."

    Same principle. How the @#$^% do these people think this is "news??"

    There is some evidence that nanoparticles can move into the brain along the olfactory nerve, so this is completely circumventing the blood-brain barrier."
    ...and in the DMT enthusiast's world, this is occasionally used to move a gigantic flippin crystal from the pouches above the upper lip, into the nerve, and into the brain - bypassing enzymatic processing in the liver...

    Every single soluable molecule becomes a disassociate, monomolecular ion in solution. This is not new, this is not remarkable, this is X,000-BC technology.

    From the amateur hobbyists perspective, it doesn't really count as nanotech until you engineer the flippin' machine one atom or so at a time, and intelligently at that.

    The grad student's trick of designing a castle, or their initials, or whatever, in a giant freakin' molecular polycyclic structure?

    Nanotech, albeit nonfunctional amusement.

    "Dude, I chopped my coke 'till it was fluffy?"

    Not nanotech.

    Simple. ...and the ironic thing is, m'self and some dawgs I run with accidentally designed a nanorobotic warfare device that we promptly refused to synth. Brutal little things, the sort of grotesque atrocity which could not only destroy all organic life, but prevent any future reseeding of organic molecules for eternity. It actually has use in the nanorobotic card-top industrial factory, but... we sorta tabled it immediately. Not worth it.

    ...this speaker, however, hasn't even touched on the most basic of nanotechnology - yet.

    ~sigh~

    Much like "herbal supplements," overfunded hype makes bullshit out of even the most interesting things. :(
  62. Actually... by jd420 · · Score: 1
    what would be better than a bomb that goes off and you breathe in particles that can easily penetrate your organs
    ...one of the non-globally-catastrophic ideas for nanowarfare was pretty simple; organ-targeted nuclear microweapons.

    Step 1 : pick a molecule that binds to a specific receptor of localized nature; the CB1 cannabinoid receptor, for instance, is almost exclusively contained in the CNS, while the CB2 provides most of the body-side anandamide operations, I believe.

    Step 2 : halogenate a random carbon. How do you do this? Boil it in chlorine, bromine, hydrochloric acid, what have one. Bonus points if it has something easily-substitutable, like an aromatic group (X2 + (FeX2 or AlX3), where "X" is any halogen) or a carboxyl group with a cute little beta carbon (HX + RCOOH)

    Step 3 : rinse in a reduced metal whose nucleus is heavy enough to have a desireable half-life...

    ...and, thanks to the existance of a half-life, one is able to say that X amount of nuclei will detonate quite specifically in organ Y over timespan Z at any time for the life of the molecule.

    Mind you - not only is this probably already heavily frowned upon by most international law, qualifying as both an unlawful chemical/pharmacological and a radiologically pollutant weapon designed to spread terror...

    ...but (aside from the ability to select one's target from a broader list) - it isn't all that new; from little boy and fat man in japan, radioisotopes of iodine have tended to concentrate, regretably, in the thyroid.

    ...this just adds the choice of nuking a specific brain region, or the gastrointestinal tract - or, grotesquely enough, one could even probably specifically target just any existant placenta, which is so horiffically against the laws of war that it canot be described - while leaving both the rest of the targeted body (gee, your own soldiers need transplants?) and the surrounding countryside intact.

    ...sick fuckin' shit, as is war, and already illegal... but, it is a bit better than one or two other toys theoretically existant...

    ...and, hey, it's not really that different from nerve gas in its lethality, though not as quick, usually. It just allows for organ-harvesting your enemy's forces fairly freely, as the organs not bound to are relatively unharmed and uncontaminated.

    ..."corneas for sale, $3.99," anyone?
  63. As a nanogeek, I second... (rti) by jd420 · · Score: 1

    Nanotechnology (n) : the utilization of the techniques of manufacturing Really Good Drugs(tm) to implement the ideas you had while on those Really Good Drugs(tm).

    ...and three weeks of manic frenzy later, my molecules of crack cocaine had robotic arms.

    If you'd like to know how to do this, it's pretty easy, actually.

    Mine a random long-chain organic acid from, say, flax-seed oil.

    Next, you need to put in more work than any chemist would want to do... form the amine of the first carbon (HCl + RCOOH -> (R-1)CClCOOH + NH3), the nitroalkane or carboxolic side-chain of the second, the amine of the third, etc...

    ...finally, halogenate the last carbon... if my vague memory serves, HS2Cl2 tends to show preference for halogenation of the terminal carbon of a carboxolic acid...

    ...and this is where the fun comes in. "Crack," e.g. freebase coke, is benzoic acid ecognovimide. You can do this with anything with a phenyl group (the benzene of benzoic acid), or use a different coupling mechanims...

    ...take two mols of your extremely-modified carboxolic acid with a halogen on the terminal carbon, one mol of your aromatic "body" of the beast, and a dash of a lewis acid catalyst, such as aluminum chloride...

    ...a bit of heat and stirring later, it'll have these long organic "arms" coming off the side, complete with carboxolic "claw" for the reversable "grabbing" of alkaline groups... and here's the best part...

    ...in distilled water, the nitrate and the amine groups will try (desperately) to salt with one another -distorting the bond angles and "contracting" the robotic arm... but in saline solution, it will be slightly more likely to "salt" with the electrolyte - extending or "relaxing" the robotic arm...

    ...and that, my friends, is how you make a series of crack-cocaine molecules with user-controllable robotic arms... or, any other organic group one wants to bind them to. For the really, really, REALLY bored - instead of binding to a phenyl group, you can just wash the end precursor in sodium hydroxide to form the terminal alcohol, and cook with H2SO4 to create long fibers of electrolyte-reactive polymer, which is far more useful, actually, than "robocrack"...

    ...and now you know some Really Important Things(tm), such as the fact that "(rti)" stands for "Random text inside"... or, that this is how those "burnout druggies" that your mom warned you not to become are ruling your world when they're not programming computers... or...

    ...nonetheless - I know how to make the "actual nanotech worthy to be afraid of," and it's not anything I posted in this thread. I feel the world would be a safer place if I posted simple nuclear instructions in easy-to-understand arabic, than if I started broadcasting the recipie, structure, or principles of the crap, which is why this is instead a complete recipie for electrolyte-reactive polymer fiber, which is "mostly harmless," and whose use is governed as far as I'm concerned wholly under the GPL.

    http://www.gnu.org/copyleft/gpl.html

    Have fun in your basement, kiddies - though like the GPL says, ya do it at your own risk...

    ...and as a final random offtopic... the crap in the article doesn't count as nanotech in the average hobbyists book, either. It's a field driven by geekdom on the molecular-hacking level - and "making a fine precipitate" is downright boring (and archaic - dissolve salt, add alcohol)... and more importantly, does not have robotic arms, legs, sensors, or spaceguns which would really turn a geek on.

    Now, if you'll pardon me - I, for one, welcome the challenge of designing our eventual nanorobotic overlords. ;)

  64. Umm... btw... by jd420 · · Score: 1
    Or try ingesting 250-500 g (1-2 hits) of lysergic acid diethylamide...
    ...isn't it a little... irresponsible... to be listing "half a kilogram" as "2 hits of LSD?" :p

    ...other than that (and strong, solid dose, even in the ug) - props on the post.
    1. Re:Umm... btw... by Anonymous Coward · · Score: 0
      ...isn't it a little... irresponsible... to be listing "half a kilogram" as "2 hits of LSD?" :p


      Ya, I missed that in the post preview, slashdot stripped the mu character, I immediately corrected the post with a reply here:

      http://science.slashdot.org/comments.pl?sid=207140 &cid=16891482

      500g would be one hell of a trip, and one hell of a shit once you came unbound! 0.5Kg is enough to get about two million people seeing faces in woodgrain.
  65. Easy enough... by jd420 · · Score: 1
    There's this little problem with replication called "energy", and the laws of thermodynamics. Making order out of disorder requires energy to be expended. Exactly where is all the energy going to come from to turn everything into "grey goo"?
    ...as catalysts only catalyze exothermic reactions, these would be the (generally, the only) reactions utilized.

    ...if one presume "grey goo" as the stipulated endpoint, it would be a well-catalyzed "grey goo" of maximal disorder. If one drop the "grey goo" demand from the thought experiment, we end up with such charming uselessness as converting all nitrogen to ammonia (iron catalyst, I believe, in the presence of hydrogen)... or all carbon into carbon dioxide (say, potassium permanganate, possibly with a ketone catalyst to kick the last carboxylic stub)...

    ...but all in all, if grey goo there be, it would be a grey goo of increased entropy... much as nuclear reactions tend to drive anything toward the "grey goo" of iron.

    ...the exception is a photocatalyst, but I really doubt we'll break out the "intricate series of solar-powered nanolasers" until well after we've explored the more normative, exothermic machinations.
  66. The answer is rational precaution... by Genda · · Score: 1

    And Strict enforcement of critical safey regulation. This is of course said in the same breath as the acknowledgement that we live in a world where people get away with illegally dumping every kind of toxic chemical horror (particularly in third world contries.)

    It's true that nano tubes can do serious biological damage, it's also true that by simply adding a terminating metal ion, those same tubes lose their biological danger. We need to make certain that we come up with sane and safe ways to create, use, and dispose of nanomaterials. This is no different than the thousands of toxic and carcenogenic materials we produce by the millions of tons today, and it's going to be a bigger problem tomorrow as new chemicals are created daily.

    This is an engineering problem, and only becomes a social problem when people inspired by greed, decide that the cost of cutting corners is worth the occassional harm or death afflicted upon strangers. We as a society need to create strong rules, with stiff punishment for breaking the rules. After that it's simply and engineering problem.

    Genda B.

  67. Rick Smalley :: Marie Curie? by Anonymous Coward · · Score: 0

    Rick Smalley is the guy who created Buckyballs. He won the Nobel for this.

    http://en.wikipedia.org/wiki/Richard_Smalley

    Rick Smalley would have breathed a lot of nanotube dust in during his life. He died of leukemia following non-Hodgkins lymphoma.

    No proof, just anecdote.

  68. some dangerous nanoparticles by emilper · · Score: 1

    we're bathed in nanoparticles every second: they are called dust