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First Image Taken With an Ultra Low Field MRI

KentuckyFC writes "MRI machines are about to get smaller, much smaller. Most of their bulk is taken up by the huge superconducting magnets required to generate fields of a few Teslas. Now a team at the Los Alamos National Lab in New Mexico has built a machine that can produce images using a field of only a few microTesla (PDF, abstract here). So giant superconducting magnets aren't necessary, a development that has the potential to make MRI machines much smaller, perhaps even suitcase-sized. The one-page paper shows sections of the first 3D brain image taken with the device."

43 of 189 comments (clear)

  1. Hidden monkeys by LiquidCoooled · · Score: 4, Informative

    I thought the images were of monkeys at first, however when I went to have a look at MRI images of a human head was thankfully proven wrong (some of us have our monkey origins hidden better than others).

    So, for comparison here is a page with images of human heads in a normal MRI.
    (single image here)

    I hope they get the focusing better (which is what I understand the power is used for) because this will be a good progression.

    --
    liqbase :: faster than paper
    1. Re:Hidden monkeys by flyingfsck · · Score: 2, Informative
      --
      Excuse me, but please get off my Pennisetum Clandestinum, eh!
  2. Article's title is misleading by IvyKing · · Score: 3, Informative
    This may be the first image of a human head with an ultra low field MRI, but ULF MRI images have been made for at least a decade and a half. Magritek, a New Zealand company, makes a low cost unit ULF MRI system, though the image volume is limited to about one liter.


    Another company, Vista Clara, is using a novel form of ULF MRI to map groundwater.

    1. Re:Article's title is misleading by kanweg · · Score: 2, Funny

      Should be big enough for early creationists.

      Bert

    2. Re:Article's title is misleading by ceoyoyo · · Score: 5, Informative

      The summary is VERY incorrect.

      This isn't an ultra low field MRI, it's a DUAL field MRI. In a normal scanner you have a big, static magnetic field that polarizes the sample and remains for readout. In one of these dual field scanners you use the big field (or a bigger field, it's usually a resistive electromagnet so it can't be anywhere near as strong as a superconductor) to polarize the sample then you shut it off and use a much smaller field for readout. There are a few advantages, the one the abstract focuses on is that you can do things like MEG in a very low field. The other is that energy deposition is related to the field strength so by using a small field you can use imaging sequences that would otherwise pump too much energy into the subject.

      One of the guys working on this technology visited my lab last year. It was a very interesting presentation.

      I believe someone has produced an MR image using the Earth's magnetic field. They've certainly done nMR in the Earth's field. You can't get much lower than that on this planet.

    3. Re:Article's title is misleading by Anonymous Coward · · Score: 4, Informative

      Earth's field and low field MRI are actually relatively common. There has even been NMR work done at ~1uT in a shielded chamber.

  3. Stronger pre-polarizatin field is used by flyingfsck · · Score: 3, Interesting

    Hmm, they use a prepolarization field of 30 mT for 1 second before using the weaker measurement field of 46 uT. So I'm wondering why they don't just use the 30 mT field and be done with it.

    --
    Excuse me, but please get off my Pennisetum Clandestinum, eh!
    1. Re:Stronger pre-polarizatin field is used by IvyKing · · Score: 3, Informative

      The Larmour frequency for 30 mT is about 1.28 MHz, which is in the AM broadcast band. Interference is likely to be a significant problem.

    2. Re:Stronger pre-polarizatin field is used by Anonymous Coward · · Score: 2, Interesting

      The Larmour frequency for 30 mT is about 1.28 MHz, which is in the AM broadcast band. Interference is likely to be a significant problem.


      If that was the reason, they would just pre-polarize to a different field. Most MRI happens in the middle of some radio band, and at ~2 KHz, there is going to be lots of interference from 60/50 Hz harmonics or other mains related EM radiation. The interference is removed by shielding the magnet / room. In this case, I think they also used a gradiometer coil which is pretty good at rejecting external interference.
  4. MRI accidents by l00sr · · Score: 4, Interesting

    Hopefully this will also put an end to those pesky MRI accidents. Not that they're common, but still, those things aren't toys.

    1. Re:MRI accidents by myth_of_sisyphus · · Score: 2, Funny

      I was in a gown prepared to get an MRI for my back and a little old lady in the waiting room with me refused to give the MRI tech her purse. She was in a gown holding her giant purse with metal snaps and buckles tightly. (An amusing image. I lol'd)

      She said "I don't want to leave my purse behind. I'll hold it really tight."

      The tech said "You can't hold it. It'll tear your arms off."

      She said "I'll just set it on a chair next to me."

      He said "You can't bring it with you. There's a big magnet in the room and it will go flying and might hit you in the head."

      She refused to give up the purse. Couldn't grasp the concept of giant purse-eating magnet. She got dressed and left.

      The MRI tech and I were laughing about it as he set me up in the machine.

  5. other implications by SuperBanana · · Score: 3, Interesting
    Off the top of my head, some plusses and negatives.

    Plusses: less (very expensive) liquid helium or (less expensive but still $$) liquid nitrogen. Less of a magnetic field means much higher MRI safety; everything from oxygen cylinders to chairs to guns have been drawn into/against MRIs (the gun was a prison guard who got pushy and DEMANDED to be in the same room as a prisoner. Yeah, the gun went off. No, nobody was hurt.)

    Negatives: since the MRI isn't as strong, it might be more affected by local magnetic fields from wiring, ferrous objects, etc. Dunno. Right now, MRIs are installed into big rooms that have as little ferrous material as possible, and then very carefully "shimmed" to adjust for the building and local magnetic fields by a technician. Even if an MRI gets down to "suitcase" size, the necessity of a "clean" environment and calibration for each location might make moving them around very tough.

    As a side note, there are already shielded MRI machines which work in a trailer and require little setup time, but being outdoors makes things easier- no building infrastructure to mess with the magnetic fields.

    1. Re:other implications by SuperBanana · · Score: 2, Informative

      I was going to make some witty comment about the bullet not going very far, but then again lead isn't paramagnetic, is it? :)

      Nope, though not all bullets are lead.

      Jokes aside, the field is very strong and ALWAYS on. The oxygen cylinder incident killed the kid who was in the MRI machine at the time; gooooo White Plains Medical center!

      Another benefit I forgot to mention is that the machine won't need to be powered up for very long, nor will it need to be quenched in the event of an emergency (which entitles dumping all the electrical energy into heat. Sometimes accidentally, like when the liquid helium coolant drops too low.) It also opens up avenues for people who have metal implants to get MRIs. It's not just magnetic attraction that is a problem; metal can be heated up by the rapidly switching field during an actual scan. High strength MRIs already do this in your *body* because of its conductivity!(we're talking the newest, highest strength human-clinical machines. Research MRIs well exceed clinical machines, and a lot of clinical machines are only a few tesla.)

    2. Re:other implications by ScrewMaster · · Score: 2, Interesting

      Some twenty-odd years ago when I was doing some research software for a teaching hospital in the city, I had noticed there was some significant construction going on, some kind of addition to the main building. I didn't know what it was for at the time. A couple months later I was walking down a hallway with one of the doctors I was working with, and noticed what looked like a two-foot-square hole in the wall that hadn't been there the day before. It had been crudely patched with plasterboard. The doctor told me that a workman had been walking by carrying a window air conditioner at the exact moment the operator was test firing the magnets for the new MRI center they had just built right next door. It literally sucked the A/C out of the guy's hands, and slammed it through the wall and out the other side. Fortunately nobody was hurt.

      I presume they must have done something to prevent such occurrences: so far as I'm aware it never happened again.

      --
      The higher the technology, the sharper that two-edged sword.
    3. Re:other implications by 2short · · Score: 4, Funny

      Ten years ago my girlfriend at the time was involved in research using NIHs 4T human machine, a 3-story tall superconducting magnet. There was a fence outside part of the building with signs saying keep out, strong magnetic fields. But one day my girlfriend told me how the director had to go running outside because some workmen digging a trench were taking down a section of the fence, preparing to bring a backhoe through. After arguing a bit with the construction foreman about this being where the trench was supposed to go, and how he really didn't think a magnet was going to hurt his backhoe, she took one of their shovels and stuck it to the wall. That got their attention long enough to explain how many millions of dollars they would owe her if their backhoe gets sucked though the side of the building and breaks her magnet.

    4. Re:other implications by tgilk · · Score: 3, Interesting

      Man, I'd love to get the details on that! I'm an architect that specializes in MRI facility design & construction and I'd love to be able to document that story.

      Another similar story, an MRI facility in Arkansas had just been built and the Fire Marshal was on his way to do the final inspection. However, before he got there, the sprinkler contractor decided to take the oxyacetylene torch rig into the room to fix a leaky sprinkler head. The magnet grabbed the tanks, drew them inside, snapped the valve off, the spark from which ignited the gases. The fire caught the magnet and building on fire, totaling both.

  6. Getting there, but not there yet. Too low-rez by Animats · · Score: 2, Informative

    Very nice. The images are still very blurry (resolution 81×61×11), and the detectors, at 37mm, are big, but it's a start.

  7. I hope they do away with the tunnels by pair-a-noyd · · Score: 4, Interesting

    I had to have several MRI & CT scans and that friggin tunnel is more than I can handle.
    They tried to put me in one with the normal little tunnel (about as big around as a five gallon bucket) and I freaked out before I got 2' into it and made them back me out. Then they put me in an "open" MRI machine but it was like being crushed under a car. No way Jose. Abort #2.
    So I went to another city where they had a different kind that was a little more "open" than #2.
    This one then pumped me full of Xanax and I survived it.

    The CT scan was not quite as bad because it was like a large doughnut and there was only about 1' of my body inside it but it still freaked me out.
    Xanax on that one too.

    I swore I'll die before I ever go in one of those damn things ever again.
    They need to come up with a better way. Some people can't handle that crap.
    I hope these new ones are a break away from the "trapped in a pipe" or "crushed under a car" machines.

    1. Re:I hope they do away with the tunnels by Dunbal · · Score: 3, Insightful

      For some reason I find that your comment suits your screen name just fine...

      Of course I understand completely that people don't have to justify their phobias, but you have to admit that you must have caused quite a few shaken heads, raised eyebrows, and sighs of exasperation on behalf of the medical staff. Especially considering that because of their scarcity such machines usually have a line of people waiting for them.

      --
      Seven puppies were harmed during the making of this post.
    2. Re:I hope they do away with the tunnels by RallyNick · · Score: 3, Insightful

      I had to have several MRI & CT scans and that friggin tunnel is more than I can handle.

      Why not use a cloth eye cover?

    3. Re:I hope they do away with the tunnels by kailoran · · Score: 4, Insightful

      I'd assume those shaking heads were muttering "geez, another one" rather than "omg wtf how can someone be afraid of it". Claustrophobia isn't all that unheard of, and being shoved into a friggin pipe is somewhat a powerful trigger.

    4. Re:I hope they do away with the tunnels by Nyago · · Score: 5, Insightful

      If it were easy (or even moderately hard) to control a phobia, I suspect most people would. Justification is irrelevant. It matters only that the fear exists. Conquering a phobia typically requires exposure (with neutral or rewarding consequences) to the fear-provoking stimulus. In his case, gradual exposure to being in the tube.

      I realize that many people find it difficult to understand the lack of control inherent in a phobia. I (with my injection phobia) am often told (by medical professionals) simply to get over it. Unfortunately, when a needle is present, I descend into blind animal panic. My rational mind ceases to function. The thoughts of controlling and pushing through the fear don't even occur to me. It is a pure flight-or-fight response, and I have done both.

      Additionally, the guilt of having wasted time (of the doctors or other patients) needlessly adds to the unpleasantness of the situation. His attempts to undergo the procedure are, in my opinion, courageous.

      People need help, not guilt or reprimands.

      --
      Reality is fluffy!
    5. Re:I hope they do away with the tunnels by FleaPlus · · Score: 2, Informative

      I had to have several MRI & CT scans and that friggin tunnel is more than I can handle.

      I haven't seen one in person yet, but there's apparently a company which produces something called the Fonar 360, which instead of having a tunnel basically turns the entire room is a magnet. This is useful not just for reducing claustrophobia, but also hypothetically allows for surgery to occur while somebody is inside of an MRI. I think the spatial resolution however is quite a bit weaker than typical scanners.

      The same company also has an Upright MRI product, where the patient sits down with open space in front of them.

    6. Re:I hope they do away with the tunnels by tsa · · Score: 2, Insightful

      It's indeed scary to be in that pipe. Not only is it very narrow and you can't get out yourself, but the machine makes very loud noises when in operation. Being inside a working MRI machine is not a fun experience.

      --

      -- Cheers!

  8. for reference, Earth's magnetic field is by Anonymous Coward · · Score: 2, Informative

    about 50 microteslas http://hypertextbook.com/facts/1999/DanielleCaruso.shtml.

    according to the Fine Article:

    The measurment field in the article is 46 microteslas.
    (A "pre-polarization" field of 30 mT (milliteslas) is appled for one second before each meaurement)

  9. Smaller == Cheaper by iknownuttin · · Score: 2, Insightful

    Smaller is nice, but what really needs to be done is to make them cheaper to purchase and operate. That way, even the local small hospitals can, hopefully, afford one. When you're sick and living out in the country, having to drive a hundred miles to the nearest machine can be quite a chore.

    --
    I prefer Flambe as apposed flamebait.
  10. In home MRI scanner by backslashdot · · Score: 3, Interesting

    I wonder if this could finally lead to an "in home" MRI scanner? If it costs under a thousand bucks and a person has a family history of cancer, why not invest in one?

    Basically the device would be conveniently rolled over the bed once a month or so and scan. It will utilize advanced 3D image analysis to compare with last couple month's scan and see if you have any growing tumors. If so then you go get a proper scan done.

    This will go well with the "in toilet" piss or shit tester that will tell you if you're going diabetic or may be developing some other medical conditions for example like kidney disease or cancer, etc..

    1. Re:In home MRI scanner by GrievousMistake · · Score: 3, Insightful

      Like other medical imaging technologies such as ultrasound, the images are medically pretty much worthless without a qualified operator to read them.
      For ultrasound systems, a far cheaper technology, the cheapest systems seem to be around $10,000. And while I could see the geek appeal of messing around with ultrasounding various animate and inanimate objects, I am sure that if the price should reach sub-1000's, it would quickly become another weapon in the arsenal of hypochondriacs and hysteric pregnant women. Much of the same goes for MRIs.

      --
      In a fair world, refrigerators would make electricity.
    2. Re:In home MRI scanner by ameline · · Score: 2, Informative

      For cancer scanning, you'd really want a PET (positron emission tomography)

      --
      Ian Ameline
  11. Re:Oy! My payments... by kmac06 · · Score: 3, Insightful

    Well you could always go back to the 19th century and avoid hospitals if you don't like modern medical advances (which are quite expensive).

  12. Re:We have determined that your brain configuratio by Dunbal · · Score: 2, Funny


    We have determined that your brain configuration predisposes you to rebellion


    (read that as: your head is still attached to your shoulders)

    --
    Seven puppies were harmed during the making of this post.
  13. Nothing _that_ new... by imsabbel · · Score: 2, Informative

    Its not like the effect used in NMR is _only_ viable at high field strengts.

    Its just that higher fields (or more correctly put, higher field gradients) allow for higher resolution.
    Looking at this publication, they archived about 5mm resulution with a 50uT field.
    Real high-end small bore scanners can get 3 orders of magniture higher.

    And the "maybe can it fit in a glovebox" part is _severely_ limited by the use of 7(!) Squids... Each of which will need a LN/LH cryosystem.

    Still, this looks quite interesting, but its not like it completely depricates the current stuff.

    --
    HI O WISE PRINCE. WHT TOOK U SO DAM LONG?
    1. Re:Nothing _that_ new... by ceoyoyo · · Score: 3, Informative

      Not quite. Higher gradients give you faster imaging. Higher fields give you better signal to noise. Better signal to noise can allow you to actually use those higher gradients without ending up with a big mess of noisy pixels.

      If you've got lots of time you can achieve more or less any resolution you want with any field strength you like. The problem is, the darn patients keep getting impatient and moving.

      The summary is pretty wildly inaccurate. This is actually a dual field scanner that uses a stronger field to polarize the sample and a weaker one for readout. It's pretty cool, but it's a niche thing... these guys want to do MEG scanning along with MRI and MEG is allergic to large magnetic fields. It won't be replacing the regular superconducting scanners and it won't be making cheap in-home scanners possible.

      You can do nMR in the Earth's magnetic field if you want to. It's actually possible to set it up at home. I think someone was selling science kits for a while.

  14. Re:Oy! My payments... by Turn-X+Alphonse · · Score: 4, Insightful

    Or you could have a sensible health care system where the rich can have giant breasts and the poor don't die from common and curable things.

    You know, just a thought.

    --
    I like muppets.
  15. Re:Oy! My payments... by guruevi · · Score: 3, Interesting

    I work at one of those MRI places and we do research and we are a non-profit. Although we're quite fully booked every day the use of the MRI still cost ~$500/hour. Basically the cost of operation divided by the number of scans done last year makes the price. Or do you think supercooling magnets to ~5K (that's Kelvin, convert to Celsius or Fahrenheit yourself) 24/7, the machine itself (~$3m) and support contract (~$125k) are paid for by the government not talking about the workstations to process the data and of course, my daily food?

    About the article: those pictures are pretty unclear but it's promising.

    --
    Custom electronics and digital signage for your business: www.evcircuits.com
  16. maybe a little bitter about this by jpfed · · Score: 4, Insightful

    I was recently charged $3000 for a CT scan. Talking to an Indian coworker, I found out that a CT scan in his country would've cost less than $50. So I guess I could've flown out to India, gotten the CT, and flown back, for less money than getting the CT in America.

    It's a good thing I did get that expensive modern medical advance in America, though, because of the high-quality analysis and follow-up I got from the clinic. In total, I got one sentence out of it- "Your intestines are a little constricted." I don't think they could provide that kind of advanced analysis in India with their cheap CT scans.

    I guess I'm wondering- are modern medical advances really as expensive as we're led to believe they are in America?

    1. Re:maybe a little bitter about this by kannibal_klown · · Score: 3, Funny

      To add insult to injury, apparently it's a growing trend to send the CT images electronically to India for a specialist to analyze.

    2. Re:maybe a little bitter about this by Squalish · · Score: 2, Interesting

      IN GENERAL:
      Medical research happens when there's money behind the disease. Once the advance is made and commoditized for great loads of money to the first world (and the research is the main thing priced, not the build construction), it can be exported to the developing world and add value slightly to their firstworld sales numbers, for little extra effort.

      If the first world didn't exist, then the developing world wouldn't have the luxury of down-marketting - they would have to get by without the tech being developed, or with the tech being a lot more expensive (somewhere between firstworld and developing world price).

      There are of course specific contradictions to this, and the US pharma market has (like most aspects of the US economy) decided to spend more on advertising and profitability than original research...

      But in a hypothetical company that puts most money towards research - for a $1 pill to exist for the third world, it has to cost $0.75 to build (yay, profit) and it has to sell to Americans for $75. Otherwise, if they couldn't count on the US market, it would be available for $5 or $10 to the whole world. And if they knew that they couldn't sell enough to make the same return on investment... they wouldn't have developed the drug in the first place.

      It's a nuanced point, and so it will never be brought up in the public discourse, ever. The debate will be "Socialized medicine?! We have the best healthcare system evar! It's where rich third world dictators bring their kids," versus people who see the rest of the world not being bled dry by their medical establishments.

      It's kind of a reverse tragedy of the commons - the AIDs drugs are going to benefit lots of poor Africans if they are developed, because production cost is virtually nil. But they won't be developed unless they can generate a good return on (their large research) investment by charging the richest nations through the nose.

      --
      People in Soviet Russia, however, appear to be afflicted with amusing juxtapositions of the aforementioned situation
  17. Re:Interesting... by tsa · · Score: 2, Interesting

    That's what I thought. People with a pacemaker for instance, can not be imaged with an MRI anymore now. Hopefully that'll change in the near future.

    --

    -- Cheers!

  18. No by backslashdot · · Score: 2, Informative

    No. It can say "the machine was unable to detect any of the types of large solid tumors we can recognize".

    Do people sue pregnancy test kits if it tells them they weren't pregnant and they drank alcohol and the baby was born with problems? Or condom manufacturs for getting deadly diseases?

    If they do, they havent been very successful .. cause those products still exist on the market.

    Disclaimers. Use them.

    DISCLAIMER: The above post is not meant to encourage or discourage anyone from getting into the home MRI business. Author assumes no liability for failure of any home MRI ventures or investments. Your success may vary. Results not typical.

  19. Re:Lower health care costs? by scottv67 · · Score: 2

    Maybe this will help bring down health care costs as hopefully these will be a lot cheaper - and hopefully no longer will hospitals in the middle of nowhere have to spend several million dollars on an MRI machine. Technology certainly doesn't have all the answers, but things like this can only lead to good.

    While some of your hospital bill is due to the cost of acquiring and maintaining the expensive machines, are you also aware that part of your bill is due to people who use the hospital's services but don't pay for those services? Larger hospitals provide millions of dollars worth of services each year to people who can't pay for their medical treatment.

    When was the last time you went into a restaurant and ordered a $24-dollar steak but had to pay $32 for that steak because 15% of the restaurants patrons are members of the "dine and dash" club? People would never stand for that. But no one complains when people use a hospital (especially the Emergency Department) and don't pay the bills associated with those services (which results in higher bills for people who *do* pay their bills).

  20. Re:Oy! My payments... by puck01 · · Score: 2, Informative

    I believe the post you are referring to mentioned a CT scan, not an MRI. While both are imaging techniques, they are quite different in how they work. MRIs are much, much more expensive in general. They require the supercooled magnets and such. A CT is essentially using the same type of radiation as in used in a normal X-RAY to get sliced images. CTs are much faster at acquiring images and the equipment is much cheaper than an MRI. Both of the factors make it much less expensive overall.

  21. Re:Oy! My payments... by squarooticus · · Score: 2, Insightful

    Or you could have a sensible health care system where the rich can have giant breasts and the poor don't die from common and curable things.

    When you can figure out how to do that without holding a gun to my head to force me to pay for it, I'll back you 100%.

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