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Scientists Build Possibly The First Man-Made Genome

hackingbear writes "Wired is reporting that researchers have created the longest synthetic genome to date by threading together four long strands of DNA. 'Leading synthetic biologists said with the new work, published Thursday in the journal Science, the first synthetic life could be just months away — if it hasn't been created already. [...] The ability to synthesize longer DNA strands for less money parallels the history of genetic sequencing, where the price of sequencing a human genome has dropped from hundreds of millions of dollars to about $10,000. Just a few years ago, synthesizing a piece of DNA with 5,000 rungs in its helix, known as base-pairs, was impossible. Venter's new synthetic genome is 582,000 base-pairs.' As a programmer, I'm most excited by the possibility of a new platform and the programming jobs that will be created by it."

26 of 264 comments (clear)

  1. Thanks for the SuperFlu, Craig! by nebrshugyo · · Score: 3, Insightful

    If Venter and company royally screw-up, and create some bug that kills us all, or turns the biosphere to a pile of gray goo, nobody's going to make any money off of dandy, new, commoditized designer life forms. Where do I complain?

    1. Re:Thanks for the SuperFlu, Craig! by Fallingcow · · Score: 4, Insightful

      I'd be more worried about the tech becoming common enough and easy enough to use that anyone with $100,000 and some spare time can make a super-virus, or a bacterium that is extremely hardy and destroys wheat or rice crops, or any number of other nasty things.

    2. Re:Thanks for the SuperFlu, Craig! by KublaiKhan · · Score: 4, Insightful

      If 'grey goo' could happen from nanotech or biotech, then bacteria would have done it already.

      So far, all that's happened is some assorted earthtone sludge.

      --
      In Xanadu did Kubla Khan
      A stately pleasure dome decree
    3. Re:Thanks for the SuperFlu, Craig! by pnewhook · · Score: 3, Funny

      That said, if more concerned citizens had access to "the button" then we'd hardly have any threat of military coup would we?

      Of course not because we'd all be dead by now.

      --
      Tesla was a genius. Edison however was a overrated hack who liked to torture puppies.
    4. Re:Thanks for the SuperFlu, Craig! by spun · · Score: 3, Interesting

      When the techniques are as cheap and simple as they are likely to become, how can you restrict access? It's like trying to restrict access to encryption.

      --
      - None can love freedom heartily, but good men; the rest love not freedom, but license. -- John Milton
    5. Re:Thanks for the SuperFlu, Craig! by Cheesey · · Score: 3, Insightful

      You forgot about all the other life on Earth.

      We are the grey goo. The plants and the bacteria had a good go at spreading all over Earth, but we spread further and faster than any previous life. The "grey goo scenario" is limited by the assumption that energy is abundant, and indeed energy (food) shortages are all that stops us covering every inch of the world.

      I, for one, welcome my fellow grey goo overlords.

      --
      >north
      You're an immobile computer, remember?
    6. Re:Thanks for the SuperFlu, Craig! by Sanat · · Score: 3, Informative

      I'm not going to argue with you about it, I was on a SAC minuteman missile combat targeting team for eight years that was responsible for setting the war plans, setting the targets, installing the launch codes and aligning the missile to true north (before some new self aligning innovations were installed) so I believe I have the right to make my point. Gravity brings down everything including all of the dirt and rock and debris that is highly radioactive. A dead zone for all who enter. That is why we have ground bursts!

      --
      And in the end, the love you take is equal to the love you make
  2. But, but... by Wylfing · · Score: 4, Funny

    But Jesus, and the Bible!

    --
    Our intelligent designer has never created an animal that we couldn't improve by strapping a bomb to it.
    1. Re:But, but... by CaptainPatent · · Score: 4, Funny

      But Jesus, and the Bible! Yes, don't worry...
      We'll be able to genetically replicate those soon too
      --
      Well, back to rejecting software patent applications.
    2. Re:But, but... by amRadioHed · · Score: 3, Funny

      Well, the easy out there is that Animals are not entirely sentient. You know it's funny, that's exactly what the dolphins and chimpanzees say about humans.
      --
      We hope your rules and wisdom choke you / Now we are one in everlasting peace
  3. Impossible? by XxtraLarGe · · Score: 3, Insightful

    Just a few years ago, synthesizing a piece of DNA with 5,000 rungs in its helix, known as base-pairs, was impossible. Yet, somehow we've managed to have life on earth...
    --
    Taking guns away from the 99% gives the 1% 100% of the power.
    1. Re:Impossible? by bumby · · Score: 3, Informative

      unless you believe in "intelligent" design, life on earth wasn't synthesized. At least not by the definition of the word in this domain.

      --
      Hey! That's my sig you're smoking there!
    2. Re:Impossible? by esampson · · Score: 5, Funny

      I have my own theory; so many things in this world annoy me that they couldn't have happened by random chance. Instead they are proof of some supreme cosmic being who shaped the world just to piss me off.

      I call my theory Belligerent Design. (with all credit to Lore Sjoberg for that joke).

  4. Program me a kudzu/marijuana hybrid. by Khyber · · Score: 3, Funny

    If that can be achieved (much like a Florida geneticist once made THC-producing orange trees) then you'll single-handedly kick the War on Drugs' ass. That would be a worthy cause right there.

    --
    Still waiting on Serviscope_minor to wake up to fucking reality and realize that Jessica Price isn't going to fuck him.
  5. Wonderful by pnewhook · · Score: 3, Insightful

    As a programmer, I'm most excited by the possibility of a new platform and the programming jobs that will be created by it.

    Geez. The LAST thing society needs is a bunch of synthesized clones running around with hacked up spaghetti code for genes.

    --
    Tesla was a genius. Edison however was a overrated hack who liked to torture puppies.
    1. Re:Wonderful by CaptainPatent · · Score: 4, Funny

      Geez. The LAST thing society needs is a bunch of synthesized clones running around with hacked up spaghetti code for genes. Yes, Comment your genes for god sake!!!
      --
      Well, back to rejecting software patent applications.
  6. An omission by leob · · Score: 3, Insightful

    The article does not say if it's methylated in the right places.

    1. Re:An omission by reverseengineer · · Score: 3, Informative
      The parent poses an important question, and as it turns out, Mycoplasma genitalium was a clever choice in that regard: its genome is so streamlined as to lack the machinery to methylate its DNA. In prokaryotes like M. genitalium, methylation is mostly used to distinguish self from non-self DNA, quite useful (restriction enzymes can be used to carve up non-self DNA then), but not strictly necessary; in eukaryotes, it plays a vital role in regulation of gene transcription, so appropriate methylation is very important.

      Analyses of M. genitalium suggest it may have orginally had methylation capabilities, but has lost them over time: http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=206970&blobtype=pdf

      In our analysis, restriction enzyme digestions of M. genitalium genomic DNA, using MspI and HpaII, did not support the fact that CpG methylation currently exists in this genome as evidenced by the identical pattern produced by both restriction enzymes (data not shown). Whether the disparity in CpG dinucleotides in the M. genitalium genome is the result of a now extinct CpG methylase activity or related instead to the codon usage of this organism will require further analysis.
      --
      "FDA staff reviewers expressed concern about the number of patients who were left out of the study because they died."
  7. whatcouldpossiblygowrong? by $RANDOMLUSER · · Score: 5, Funny

    "As a programmer, I'm most excited by the possibility of a new platform and the programming jobs that will be created by it."
    As a programmer, when I think of the quality of the HTML on most websites, and then read the above sentence, I throw up in my mouth a little.
    --
    No folly is more costly than the folly of intolerant idealism. - Winston Churchill
  8. Ewww! by monkeyboythom · · Score: 5, Funny

    As a programmer, I'm most excited by the possibility of a new platform and the programming jobs that will be created by it.

    As a regular guy, I am NOT excited by the thought of thousands of fat, greasy programmers drooling over a test tube and a well worn copy of "Weird Science."

    As my friend Han was so fond of saying, "I've got a bad feeling about this."

    1. Re:Ewww! by beav007 · · Score: 4, Funny

      ...designing a woman that doesn't vocal cords!
      I think you a word there...
  9. Procedural Abstraction by Aram+Fingal · · Score: 3, Insightful

    In the article, Venter says that they will need something similar to high level programming tools in order to accomplish useful modifications. I think that there is already plenty of evidence that genetic systems have procedural abstraction. In talking about gene activation, Biologists often use the term "ordered cascade" to describe what's happening when one gene activates a few more and those genes, in turn, activate other genes. If you think about it, it's exactly like subroutines of a program. Construction of the bacterial flagellum, for example, starts with the activation of one gene, which activates others, leading to the contribution of about 25 genes. These genes contribute various parts of the flagellum and activation of the cellular machinery to put it together and attach it to the cell wall.

  10. So 582k? by Guysmiley777 · · Score: 3, Funny

    582k ought to be enough for anybody.

    --
    Coding with assembly is like playing with Legos. Coding an application in assembly is like building a car with Legos.
  11. Re:I used to be a paranoid... by orclevegam · · Score: 3, Funny

    Whenever I think somebody, anyone, not just supreme cosmic beings, is trying to piss me off, I think: am I really that important? Why, exactly, would anyone make an effort to piss me off? Nah, probably just a coincidence. You're trying to piss me off aren't you?
    --
    Curiosity was framed, Ignorance killed the cat.
  12. It's not paranoia if they're really out to get you by Goldarn · · Score: 4, Funny

    Whenever I think somebody, anyone, not just supreme cosmic beings, is trying to piss me off, I think: am I really that important? I used to wonder about this. Then I realized that, since the cosmic beings/universe/whatever are trying to piss my off, then I am, ipso facto, that important. It did wonders for my self-esteem.

    Still, I can't help but wonder... is the entire universe against me? Or just the part where light has reached since my birth? Don't laugh; it's an important question.
  13. It's called transubstantiation. by Peter+Trepan · · Score: 5, Funny

    You need a genetic sample [of Christ]

    Acquire a Catholic who has just taken communion and induce him to vomit, thereby producing a viable sample of body and blood.

    Who says science and faith aren't compatible?

    --

    Step into a huge movement. Don't Tread In Me.