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Secrets of Schizophrenia and Depression "Unlocked"

Oracle Goddess writes "According to the US National Institute for Mental Health in Bethesda, Maryland, scientists have discovered a remarkable similarity between the genetic faults behind both schizophrenia and manic depression in a breakthrough that is expected to open the way to new treatments for two of the most common mental illnesses, affecting millions of people. Previously schizophrenia and depression were assumed to be two separate conditions, but the new research shows for the first time that both have a common genetic basis that leads people to develop one or the other of the two illnesses."

334 comments

  1. Thanks by Anonymous Coward · · Score: 2, Funny

    i'd like to thank Steve Ballmer for making himself available for this important breakthrough.

    1. Re:Thanks by eldavojohn · · Score: 3, Informative

      i'd like to thank Steve Ballmer for making himself available for this important breakthrough.

      Steve says, "show yourself, human!"

      --
      My work here is dung.
  2. This is a very interesting finding by BadAnalogyGuy · · Score: 5, Funny

    No it isn't, you moron. These people are lying. They're all lying.

    1. Re:This is a very interesting finding by Anonymous Coward · · Score: 3, Funny

      BadAnalogyGuy forgot to take his lithium today.

    2. Re:This is a very interesting finding by BadAnalogyGuy · · Score: 2, Funny

      Shut up. Shut up! SHUT UP!

    3. Re:This is a very interesting finding by Anonymous Coward · · Score: 0

      Shut up. Shut up! SHUT UP!

      And his whiskey.

    4. Re:This is a very interesting finding by Maxo-Texas · · Score: 3, Funny

      We are very happy that a solution has been found. REALLY HAPPY!!!!!!!!!! JOY AND BUTTERFLIES OH THE WORLD IS WONDERFUL ...

      oh what the heck, there is no point, I might as well just give up.

      --
      She was like chocolate when she drank... semi-sweet at first and then increasingly bitter.
    5. Re:This is a very interesting finding by Anonymous Coward · · Score: 3, Informative

      You seem to have the same faulty knowledge of Schizophrenia as most. What you are talking about is something like Dissociative identity disorder. Being Schizophrenic doesn't mean you have multiple personalities. I should know as I'm Schizophrenic myself.

    6. Re:This is a very interesting finding by sy5t3m · · Score: 1

      I should know as I'm Schizophrenic myself.

      Yes, but are you paranoid?

    7. Re:This is a very interesting finding by onemorechip · · Score: 1

      Thanks, every little bit of information I can get about you helps answer the question in my sig.

      --
      But, I wanted socialized health insurance!
    8. Re:This is a very interesting finding by morcego · · Score: 1

      WHO TOLD YOU THAT ?!?!?!?!?

      --
      morcego
    9. Re:This is a very interesting finding by treeves · · Score: 1

      Sounds like bipolar disorder you've got. Just like my (and I assume all) 18 month old daughter. She looks at me and smiles and laughs and then looks back at her mom and remembers she was crying for something a second ago, and goes back to crying.

      --
      ...the future crusty old bastards are already drinking the Kool-Aid.
    10. Re:This is a very interesting finding by sy5t3m · · Score: 2, Funny

      I communicate with the voices in your head!

    11. Re:This is a very interesting finding by Brigadier · · Score: 1

      we don't appreciate you making fun of us like that.... we all have feelings too.

    12. Re:This is a very interesting finding by theydidnthavemyname · · Score: 1

      I think he was going for bipolar not schizophrenia. Ended up somewhere near cyclothymia though.

    13. Re:This is a very interesting finding by Golddess · · Score: 1

      bipolar == manic depression

      --
      "I'm not sure I like the fugnutish tone you used in your post!" -RogL (608926)-
    14. Re:This is a very interesting finding by dudpixel · · Score: 1

      My doctor says I'm paranoid.

      Well he didn't actually say it, but I'm sure he's thinking it...

      --
      This seemed like a reasonable sig at the time.
    15. Re:This is a very interesting finding by Zencyde · · Score: 2, Funny

      Tom?

      --
      What day is it? Could you please tell me?
    16. Re:This is a very interesting finding by Anonymous Coward · · Score: 0

      Paranoia and self-absorption, as well as an irrational belief that the world is out to get you and that you're right no matter how wrong you may be are also characteristic....if you'd bothered to read the second half of TFS, you might see mention of manic depressive disorder, of which he was making fun. Look it up and then do what the voices tell you to do.

  3. I find this highly dubious... by blahplusplus · · Score: 0, Redundant

    ... how would they determine how they are related in the first place? Especially given the complexity of these issues in their relation to the central nervous system.

    1. Re:I find this highly dubious... by blueg3 · · Score: 1

      I bet they tested it on superintelligent rats.

    2. Re:I find this highly dubious... by Anonymous Coward · · Score: 1, Funny

      I bet they tested it on superintelligent rats.

      Am I pondering what I'm pondering? I think so, self, but next time, I wear the tutu.

    3. Re:I find this highly dubious... by $RANDOMLUSER · · Score: 4, Funny

      Statistical correlation. You know, like the link between tooth-brushing and intravenous drug abuse.

      --
      No folly is more costly than the folly of intolerant idealism. - Winston Churchill
    4. Re:I find this highly dubious... by ColdWetDog · · Score: 4, Informative

      I know this is Slashdot and all, but that is rather the point of TFA. In fact, for a change, it does a reasonably good job.

      Recommended.

      --
      Faster! Faster! Faster would be better!
    5. Re:I find this highly dubious... by geekoid · · Score: 4, Insightful

      Just becasue they are complex doesn't mean the information can't be found.

      Just becasue something is unknown doesn't mean it's unknowable.

      --
      The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
    6. Re:I find this highly dubious... by cowbutt · · Score: 3, Informative

      Similarity of some symptoms, medication that is effective for both conditions, a history of one or other condition in a person's ancestry...

    7. Re:I find this highly dubious... by Anonymous Coward · · Score: 0

      QTL Mapping. Basically, compare gene expression patterns in the brains of those [usually mice] known to have the disorder vs. "normal" ones, and determine which genes are being expressed. Subtract out the common ones. Then do the same for those known to have a different disorder. Lather, rinse, repeat. The union of those trait loci is what's common to both. Large amount of commonality suggests a relationship.

      See: www.genenetwork.org/home.html for more...

    8. Re:I find this highly dubious... by UncleTogie · · Score: 4, Insightful

      ... how would they determine how they are related in the first place? Especially given the complexity of these issues in their relation to the central nervous system.

      Same way they diagnose people. They guess.

      Psychiatry is the only industry where someone can present the same affect to 10 shrinks and get 10 different diagnoses. Trust me on this.

      ...and no, no Dianetics, e-meters, or Xenu for me, thanks for asking.

      --
      Don't tell me to get a life. I'm a gamer; I have LOTS of lives!
    9. Re:I find this highly dubious... by MindKata · · Score: 1

      "I bet they tested it on superintelligent rats."

      If they were that superintelligent, wouldn't they prefer to test it on their less intelligent human scientist subjects?.

      Pinky: Gee, Brain, what are we going to do tonight?

      Brain: The same thing we do every night, Pinky - try to take over the world!

      --
      There are 10 kinds of people in the world... those who understand binary and those who don't.
    10. Re:I find this highly dubious... by vertinox · · Score: 1

      What does this have to do with being British?

      --
      "I am the king of the Romans, and am superior to rules of grammar!"
      -Sigismund, Holy Roman Emperor (1368-1437)
    11. Re:I find this highly dubious... by blueg3 · · Score: 1

      I'm not sure you understand how statistical correlation works.

    12. Re:I find this highly dubious... by avandesande · · Score: 1

      Actually I bet you there is a negative correlation between tooth brushing and intravenous drug abuse.

      --
      love is just extroverted narcissism
    13. Re:I find this highly dubious... by MenThal · · Score: 1

      Donald Rumsfeld, is that you?

    14. Re:I find this highly dubious... by blueg3 · · Score: 1

      The rats? No, they prefer to escape their confinement at NIMH and form a society near a farm. Occasionally, they save mice with pneumonia, write books, and sign animated film deals.

    15. Re:I find this highly dubious... by Gilmoure · · Score: 2, Funny

      I don' thing t'hose words mean whad you ting dey mean.

      --
      I drank what? -- Socrates
    16. Re:I find this highly dubious... by Captain+Electrode · · Score: 1

      Poit! Troz!

    17. Re:I find this highly dubious... by ElectricRook · · Score: 2, Interesting

      That's an interesting correlation.

      I find it easier to measure the "tooth to tattoo" ratio. Having been an EMT in a past life, I've observed that those who have more tattoos than teeth have a much higher likelihood of dying in an emergency room. Granted this is just a loose hypothesis based on my random observations. YMMV

      --
      - High Tech workers, please say NO to Union Carpenters, their Union sees fit to control our compensation.
    18. Re:I find this highly dubious... by Anonymous Coward · · Score: 0

      Politics. You'd get 11.

    19. Re:I find this highly dubious... by electrons_are_brave · · Score: 3, Interesting
      how would they determine how they are related in the first place? Especially given the complexity of these issues in their relation to the central nervous system

      How "they" are related? By "they" you mean bipolar and schizophrenia? Apart from looking at the co-morbidity of the two conditions, they also use data from studies looking at rates in identical twins, non-identical twins, siblings who have various degrees of genetic overlap versus the overal prevelance. Plus, in a logical, theoretical sense there is diagnostic overlap -bipolar, in a severe from can include delusions, halluncinations, highly inappropriate behaviour, loss of inhibition, sleeplessness, irritability and paranioa, as can some forms of schizophrenia. Likewise, social withdrawal, lack of affect, hyposomnia ect which can occur in the depressed phase of bipolar can also occur in some sorts of schizophrenia. This is the same as any sort of medical diagnosis - both pneumonia, the flu and asthma involve breathing difficulties, so it's not too far fetched to think that there might be some common underlying mechanisms. So that points where to look.

      There's a lot more than this, of course. But epidemiology and reasoning are really the only is the only way you really can go, given that you can't ever get random assignment to conditions and can't "give" someone BP or schizo. So it's got to be correlation.

      If you meant something different by "they" then I'm not sure.

  4. I used to be schizophrenic by jayme0227 · · Score: 3, Funny

    But we're all better now.

    I know, I know, that's dissociative identity disorder, but you still laughed. Maybe.

    --
    But then I realized the cable was blue, so I only gave it one star. I hate blue.
    1. Re:I used to be schizophrenic by schon · · Score: 2, Funny

      I know, I know, that's dissociative identity disorder, but you still laughed.

      Roses are red,
      Violets are blue,
      I'm schizophrenic,
      And so am I.

    2. Re:I used to be schizophrenic by geekoid · · Score: 4, Funny

      I was until I shot myself in the head after destroying the nations credit system.

      --
      The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
    3. Re:I used to be schizophrenic by Xerolooper · · Score: 1

      I was until I shot myself in the head after destroying the nations credit system.

      You my friend are the all knowing all seeing cr*p of the world.

      --
      "The stupid neither forgive nor forget; the naive forgive and forget; the wise forgive but do not forget." -Thomas Szasz
    4. Re:I used to be schizophrenic by mcgrew · · Score: 1

      The voices in my head all tell my you're lying.

    5. Re:I used to be schizophrenic by linhares · · Score: 1

      don't say these things

      you are a unique snowflake

    6. Re:I used to be schizophrenic by knarfling · · Score: 1

      Only two of my personalities have delusions, but one of them is paranoid and the other is out to get him.

      I was told that I am just scary, and it is true. I have even been known to scare myself, but I do get even. I pinch me when I am not looking.

      --
      Great civilizations have lived and died on false theories. Don't mess up mine with a few facts.
    7. Re:I used to be schizophrenic by networkconsultant · · Score: 1

      If you talk to god it's called "Prayer"....

      If god talks to you it's called "Schizophrenia"...

      If you make sense when "God" Talks to you, the establishment quickly martyrs you in fear of losing their place...
      It's no wonder I'm always depressed....

    8. Re:I used to be schizophrenic by damien_kane · · Score: 1

      People just don't understand you, do they?

    9. Re:I used to be schizophrenic by Anonymous Coward · · Score: 0

      I laughed!
      We did too!!

    10. Re:I used to be schizophrenic by popeye44 · · Score: 1

      That was a bumper sticker on my car in 1985. Next to the one that states

      It takes 1485 screws and bolts to put a car together but only one nut to scatter it all over the road.

      --
      Inane Comments are Generously Disregarded
    11. Re:I used to be schizophrenic by tech_fixer · · Score: 0

      No, no, no... You shot yourself a couple minutes BEFORE destroying the nations credit system.

      Man, get your delusions straight!

      Or at least tell one of your other personalities to audit for you. That might actually be an interesting conversation...

      "Did you ckeck everything? / Yes you did / Ok then, approve the release of Windows 7, THAT will destroy the nations credit system."

    12. Re:I used to be schizophrenic by MattXBlack · · Score: 1

      That sort of delusion (suicidal, blaming oneself) is more likely to be associated with a psychotic episode as part of depression or the depressed part of bipolar disorder. Schizophrenic delusions are more likely to be bizarre (think aliens) and may involve a belief that one is being controlled by others, or that one's thoughts are being broadcast or played on the tv, or that one can hear others' thoughts. That said, depression is often a comorbid factor of schizophrenia, and it is entirely possible that a schizophrenic person would think that, but the example you gave is not stereotypical.

    13. Re:I used to be schizophrenic by Anonymous Coward · · Score: 0

      Nice Enron reference. I'm assuming you're referring to http://en.wikipedia.org/wiki/J._Clifford_Baxter or did I miss something?

  5. It's Not a "Disease" by RobotRunAmok · · Score: 3, Funny

    It's an Orientation.

    Get with the program.

    1. Re:It's Not a "Disease" by Anonymous Coward · · Score: 0

      Time for a Multi-Pride event

    2. Re:It's Not a "Disease" by IflyRC · · Score: 3, Informative

      I just want to be able to marry myself and file myselves as a depedents.

    3. Re:It's Not a "Disease" by gestalt_n_pepper · · Score: 1

      I suppose telling you to go f*ck yourself would be a romantic suggestion and not an insult?

      --
      Please do not read this sig. Thank you.
    4. Re:It's Not a "Disease" by Anonymous Coward · · Score: 0

      It's an Orientation.

      The politically correct term would be Asiantation.

    5. Re:It's Not a "Disease" by Gilmoure · · Score: 1

      It's quite soothing.

      --
      I drank what? -- Socrates
    6. Re:It's Not a "Disease" by gestalt_n_pepper · · Score: 1

      In that case, go f**k yourself. Twice.

      --
      Please do not read this sig. Thank you.
    7. Re:It's Not a "Disease" by Gilmoure · · Score: 1

      Ooh, thank you!

      --
      I drank what? -- Socrates
    8. Re:It's Not a "Disease" by Anonymous Coward · · Score: 0

      Congratulations on creating the most intentionally brain-hemorrhage inducing sentence I think I've ever seen on /. You win the internets.

  6. Warning by Anonymous Coward · · Score: 3, Funny

    BadAnalogyGuy (945258) is a scientologist.
    If he contacts you about a free personality test, firmly refuse him.

    1. Re:Warning by BadAnalogyGuy · · Score: 5, Funny

      You're glib. You don't know the history of psychiatry. I do.

    2. Re:Warning by MindKata · · Score: 2, Insightful

      "You're glib. You don't know the history of psychiatry. I do."

      BadAnalogyGuy, judging from your other posts on this thread, you sound like you've probably got more drugs in you than Amy Wine-warehouse on a "I've just forgot the world getting high day" (Its a national holiday in Amsterdam), so I guess you were probably there when they opened Bethlem as a hospital in the 13th century. ;)

      (Bethlem as in i.e. ... http://en.wikipedia.org/wiki/Bethlem_Royal_Hospital)

      (See humor and a relevant educational history lesson all in one neatly packaged post ;)

      --
      There are 10 kinds of people in the world... those who understand binary and those who don't.
    3. Re:Warning by Anonymous Coward · · Score: 0, Informative

      Given that 'Funny' doesn't award karma, it's just to amuse us.

    4. Re:Warning by Anonymous Coward · · Score: 0

      No, this is just his way of trying to be as leaky a screwdriver as he can.

    5. Re:Warning by RichardJenkins · · Score: 2, Funny

      You're glib.

      You mean he provides the core object system used in GNOME?

    6. Re:Warning by Anonymous Coward · · Score: 0

      And I'm qt4-lib

    7. Re:Warning by Zencyde · · Score: 1

      I hate you. Die die die.

      --
      What day is it? Could you please tell me?
    8. Re:Warning by shiftless · · Score: 1

      You mean he provides the core object system used in GNOME?

      No--he IS the core object system used in GNOME. Glib became self-aware at 2:14am EDT August 29, 2008. God help us all....

  7. Downside by Ukab+the+Great · · Score: 4, Funny

    This could be very bad for the tin foil hat industry.

    1. Re:Downside by gyranthir · · Score: 1

      Why oh why do I read /. at work? Bursting out laughing in the middle of the cube farm can cause much staring... But either way, if this is real, this could be a boon for many. Especially the young that face this and are being assaulted by their own hormones...

    2. Re:Downside by Darkness404 · · Score: 1

      If you are truly paranoid though, you extract your own tin and make it into foil then fold the foil into hats. Its the only way to be sure.

      --
      Taxation is legalized theft, no more, no less.
    3. Re:Downside by BadAnalogyGuy · · Score: 1

      It should be pointed out that tin foil doesn't really prevent the message from infiltrating your brain waves. Aluminum foil works great, though.

    4. Re:Downside by nine-times · · Score: 1

      How do you know the government didn't put fake tin into the ground? They do that, you know.

    5. Re:Downside by Anonymous Coward · · Score: 0

      Nice try. Why don't you tell them all that your real name is Joe Alcoa? Huh? Huh? Tell me that, Mr Wise Guy.

    6. Re:Downside by davidbrit2 · · Score: 1

      On the contrary, now you'll be able to purchase tinfoil hats that also play cheerful music.

    7. Re:Downside by Sulphur · · Score: 1

      Its tin foil hat resonator.

    8. Re:Downside by camperdave · · Score: 2, Informative

      No. It's real tin. They WANT you to put on tinfoil hats. That's because they've got UNDERGROUND SENSORS and the tinfoil hat makes a PERFECT PARABOLIC DISH that focuses on the brain. NEVER step on those grates in the sidewalk.

      --
      When our name is on the back of your car, we're behind you all the way!
    9. Re:Downside by damien_kane · · Score: 2, Funny

      If you are truly paranoid though, you extract your own tin and make it into foil then fold the foil into hats. Its the only way to be sure.

      No, the only way to be sure is to nuke the site from orbit. Yours is a distant second, though.

    10. Re:Downside by Alzheimers · · Score: 1

      The tin foil hat industry has been gone a long time. Most people have switched to Aluminum.

    11. Re:Downside by joocemann · · Score: 1

      You mean the aluminum foil industry. Chances are, they are making the hats and the reasoning for them, all on their own.

  8. Need to slow down when reading the article titles by Minwee · · Score: 4, Funny

    "Achievement unlocked: Secrets of Schizophrenia and Depression!"

  9. I find it highly dubious by ihatewinXP · · Score: 3, Informative

    ... how would you determine how they are related in the first place if you dont RTFA? Especially given the complexity of these issues in their relation to your understanding of them.

    There, fixed it.

    --
    ---- The real Slashdot is still here. You just have to browse at -1 to read the comments.
    1. Re:I find it highly dubious by interkin3tic · · Score: 1

      Slashdot: replacing scientific skepticism with "If it isn't summed up so as to fit in a twiter post, it is a lie."

  10. Science for the win! by geekoid · · Score: 2, Insightful

    More articles like this one, please.

    --
    The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
    1. Re:Science for the win! by cool_story_bro · · Score: 4, Informative

      I just wish the summary were better. The title and summary use Depression and Manic Depression interchangeably, which is just dead wrong.

      --
      You must wait a little bit before using this resource; please try again later.
    2. Re:Science for the win! by Anonymous Coward · · Score: 0

      Since I didn't RTFA because I'm a lazy ass, which is it the article refers to? I'm going to assume it's actually referring to BPD since that seems way more in line with schizophrenia than general depression.

  11. Manic Depression..... by Anonymous Coward · · Score: 0, Offtopic

    Manic Depression's touching my soul,
    I know what I want,
    but I just don't know how to go about getting it.

    Feeling, sweet feeling
    drops from my finger, fingers
    Manic Depression's captured my soul.

    Woman so willing the sweet cause in vain,
    you make love,
    you break love,
    it's-a all the same when it's...
    when it's over.

    Music sweet music,
    I wish I could caress, caress, caress.
    Manic Depression's a frustrating mess.
    Well, I think I'll go turn myself off an' go on down.

    Really ain't no use me hanging around.
    Oh, I gotta see you.

  12. manic depression is biopolar disorder by Anonymous Coward · · Score: 5, Informative

    ... it is not the 'depression' you may be lead to believe.

    1. Re:manic depression is biopolar disorder by idontgno · · Score: 1

      Ha! We are immune to your Jedi mind tricks! Now move along, since these aren't the droids we're looking for.

      --
      Welcome to the Panopticon. Used to be a prison, now it's your home.
    2. Re:manic depression is biopolar disorder by Anonymous Coward · · Score: 0

      This is not the depression you're looking for... (Waves had) Move along.

  13. Clarification by Peregr1n · · Score: 2, Informative

    That would be CLINICAL depression. As in, the type caused by a chemical imbalance in the brain; as opposed to the type caused by your wife leaving you.

    1. Re:Clarification by $RANDOMLUSER · · Score: 5, Funny

      No, that would be elation.

      --
      No folly is more costly than the folly of intolerant idealism. - Winston Churchill
    2. Re:Clarification by russotto · · Score: 4, Informative

      That would be CLINICAL depression. As in, the type caused by a chemical imbalance in the brain; as opposed to the type caused by your wife leaving you.

      Despite the drug company propaganda, there's no objective test to distinguish the two. In general the levels of neurotransmitters in a patient's brain aren't measured anyway... and even if they were, there's no available way to tell if the levels were what they were because of some physical issue, or if they're that way because your wife left you.

      However, TFA is talking about bipolar disorder, which is not the same as clinical depression.

    3. Re:Clarification by Dzonatas · · Score: 1

      Clinical depression is someone who is experiencing depression and diagnosed as such. Someone that experiences a number of depression symptoms for a period of time without an immediate reason why for each episode is then determined to have major depression (unipolar) or bipolar disorder.

      ... from someone that is certified disabled from being unipolar.

    4. Re:Clarification by mcgrew · · Score: 2, Informative

      The type cause by your wife leaving you is called "adjustment disorder with depressed mood", and they'll prescribe the same drugs as they prescribe for depression (SSRIs like Paxil and Zoloft).

    5. Re:Clarification by mcgrew · · Score: 1

      I was at Felber's the other night, and some fat drunk said "My doctor told me I needed to lose 200 pounds, but the bitch won't leave!"

    6. Re:Clarification by Llywelyn · · Score: 1

      No, that would be *bipolar disorder* which is not the same thing as *clinical depression.*

      Major depressive disorder (clinical depression) can also be triggered by a grief incident.

      --
      Integrate Keynote and LaTeX
    7. Re:Clarification by Duradin · · Score: 1

      Only until you see the divorce settlement. And definitely not after you've worked out what class of hooker you could have used for the same amount the divorce cost you (the Paul McCartney formula).

    8. Re:Clarification by that+IT+girl · · Score: 1

      In other words, it's called "bullshit" or the lesser-known name, "a good way for us to make money selling our drugs to people who don't need them, with no concern for their long-term well-being".

      --
      10 FILL MUG WITH COFFEE
      20 DRINK COFFEE
      30 GOTO 10
    9. Re:Clarification by hab136 · · Score: 1

      Only until you see the divorce settlement. And definitely not after you've worked out what class of hooker you could have used for the same amount the divorce cost you (the Paul McCartney formula).

      Q: Why is divorce so expensive?

      (drumroll)

      A: Because it's worth it!

    10. Re:Clarification by geminidomino · · Score: 1

      McLintock! (1963)

      Drago: Divorce? Is that when you pay a woman not to live with you?
      GW: That about covers it.*
      Drago: Some women I know, it'd be worth it.

      (*Not sure of this line)

    11. Re:Clarification by Hurricane78 · · Score: 3, Informative

      Exactly. Especially in times, where people prefer to take meds, instead of healing their problems, it should always be made very clear, that there is a huge difference between genetic disorders, and environment-based disorders. And that there also is a huge difference between intoxication (bad food, toxic waste, polluted nature, etc) and purely psychological influences (evil people, mind-boggling events, wars, extreme mobbing, and especially bad parents).

      Because the last one can't be cured by and medicine at all! At least not in your lifetime.
      It can only be partially overlayed, and numbed down, having more bad than good effects.
      That kind has to be treated with a proper psychotherapy. With the help of someone, who does not fear to take you at the hand and help you go to the deepest and darkest place in your soul, to face it. Luckily this has a very good chance of really healing you.

      But the genetic kind of course can only be treated with meds.

      It is very important to make this distinction, for sure.

      --
      Any sufficiently advanced intelligence is indistinguishable from stupidity.
    12. Re:Clarification by tsm_sf · · Score: 1

      Despite the drug company propaganda, there's no objective test to distinguish the two. In general the levels of neurotransmitters in a patient's brain aren't measured anyway... and even if they were, there's no available way to tell if the levels were what they were because of some physical issue, or if they're that way because your wife left you.

      That's why you go to a doctor.

      --
      Literalism isn't a form of humor, it's you being irritating.
    13. Re:Clarification by samkass · · Score: 1

      As an aside, your comment was especially amusing juxtaposed with your sig.

      Please don't try to diagnose or treat folks without training or examination.

      --
      E pluribus unum
    14. Re:Clarification by vertinox · · Score: 1

      In other words, it's called "bullshit" or the lesser-known name, "a good way for us to make money selling our drugs to people who don't need them, with no concern for their long-term well-being".

      If it makes you feel better than who is to say you don't need them?

      Personally, I find it cheaper to get rid of my depression in a nice strong bottle of vodka or red wine.

      If people want to smoke pot or pop pills to feel better, that is there business.

      If you let a pusher in a Doctor's coat or a leather jacket convince you need to take the drugs, then that is your problem.

      --
      "I am the king of the Romans, and am superior to rules of grammar!"
      -Sigismund, Holy Roman Emperor (1368-1437)
    15. Re:Clarification by Anonymous Coward · · Score: 0

      The difficulty there is finding a doctor who has a clue what to do about it.

      Aside from the shot-gun prescription drugs method.

    16. Re:Clarification by Cross-Threaded · · Score: 1

      That's why I call the local bartender "Doctor".

      --
      They call us sheeple, I wonder why?
    17. Re:Clarification by Cross-Threaded · · Score: 1

      Oh, yeah. I also say to the cocktail servers, "Nurse, may I have another i.v.?"

      --
      They call us sheeple, I wonder why?
    18. Re:Clarification by maxwell+demon · · Score: 1

      Oh, and I thought it was economic depression and a schizophrenic financial system ... :-)

      --
      The Tao of math: The numbers you can count are not the real numbers.
    19. Re:Clarification by mcgrew · · Score: 2, Interesting

      That's entirely correct, at least in my case. I'd have been far better off riding out the pain than taking the Paxil. The worst part was, they took me off Paxil right as I and my then-teenaged daughter were moving out of my foreclosed home into a tiny apartment. "My ROOM was bigger than this apartment," she wailed.

      The thought of what it would do to my kids and especially my parents if I killed myself is the only thing that kept me alive. Suicidal thoughts are one of the withdrawal effects of Paxil.

    20. Re:Clarification by mcgrew · · Score: 1

      There's a bar in town (now called the Blue Grouch) that was named "Doc's Lounge".

    21. Re:Clarification by gestalt_n_pepper · · Score: 1

      Well, there is if you don't mind having your brain ground up and assayed in a test tube, but you're probably fussy about that sort of thing.

      --
      Please do not read this sig. Thank you.
    22. Re:Clarification by electrons_are_brave · · Score: 1
      Doctors are notoriously bad a dealing with psychopathology, which is why so many people end up on meds. And you are unlikely to see a psychiatrist unless you are (a) very ill or (b) rich (c) have some f'ing fabulous health cover.

      But that doesn't make psychological research invalid ("bullshit" as you put it). It's great research - and even if it ends up being wrong or party wrong, it's another small step.

    23. Re:Clarification by dickens · · Score: 1

      Unless your wife left you because you were clinically depressed. It can be hard to separate cause from effect sometimes.

    24. Re:Clarification by that+IT+girl · · Score: 1

      Thanks for the advice :P but this *entire thread* was full of folks doing that to some degree.
      If you don't think meds are overprescribed and that far more people are taking them than should be, you are insane. (Oops, did that last bit count as another "diagnosis"?)

      --
      10 FILL MUG WITH COFFEE
      20 DRINK COFFEE
      30 GOTO 10
    25. Re:Clarification by that+IT+girl · · Score: 1

      "If it makes you feel better than who is to say you don't need them?"
      A lot of things make a person feel better temporarily, but are not good for the person.

      --
      10 FILL MUG WITH COFFEE
      20 DRINK COFFEE
      30 GOTO 10
    26. Re:Clarification by Anonymous Coward · · Score: 0

      Didn't you mean lack of felation instead?

    27. Re:Clarification by Sockatume · · Score: 1

      Specifically the "serotonin hypothesis" of endogenous depression seems to be a shambles. SSRIs help in some cases but it's clear that low seratonin levels aren't the underlying cause of depression, endogenous or otherwise.

      --
      No kidding!!! What do you say at this point?
    28. Re:Clarification by aqk · · Score: 0

      You're confused.
      Manic-Depression is when-

      -Your wife leaves you....

      -
      ... but,
      THEN COMES BACK!

  14. So what is it? by Itninja · · Score: 1

    "Depression" of "manic depression"(aka bipolar disorder)? These are two very different things.

    --
    I judt got a nre Kinesis keybiartf so please excusr ant egregiou typos.
    1. Re:So what is it? by mcgrew · · Score: 5, Informative

      Indeed, the disease is no longer called "manic depression". It's "bipolar disorder" now. And BTW, schitzophrenia is not multiple personalities, that one is called "disassociative identity disorder". Schitzophrenics experience delusions, like changing their memories of a movie or TV show into memories of their own life experience; or hallucinations, like hearing voices in their heads telling them what a terrible person they are.

      Depression is a completely different disease and often leads to suicide and usually leads to drug or alcohol abuse, although the metal health industry usually blames the substance abuse for the depression that started before the substance abuse did.

      You meet a lot of crazy people in bars. One guy I saw in a bar said "I'd rather have a bottle in front of me than a frontal lobotomy".

    2. Re:So what is it? by Itninja · · Score: 1

      schitzophrenia [sic] is not multiple personalities, that one is called "disassociative identity disorder"

      Yeah but hillbillies want to be called 'Sons of the Soil', but it's never going to happen....

      You meet a lot of crazy people in bars. One guy I saw in a bar said "I'd rather have a bottle in front of me than a frontal lobotomy".

      That was kind of a non-sequiter. Was this person Dorothy Parker? Because she's the one who said that originally...

      --
      I judt got a nre Kinesis keybiartf so please excusr ant egregiou typos.
    3. Re:So what is it? by TheCycoONE · · Score: 1

      And Disassociative identity disorder was previously referred to (and still is by some standards) as MPD or Multiple Personality Disorder, which in my humble opinion is quite a bit clearer.

    4. Re:So what is it? by Lemming+Mark · · Score: 4, Insightful

      schitzophrenia [sic] is not multiple personalities, that one is called "disassociative identity disorder"

      Yeah but hillbillies want to be called 'Sons of the Soil', but it's never going to happen....

      I'm not sure where you're going with that one... Sure, in general usage a language is defined by the whims of the people who speak it. But when it's technical jargon - in this case medical jargon - the technical definition, as opposed to "what everyone calls it" is rather important! I've had friends who call a CRT monitor "the computer", yet my CRT is still unable to function without the part that the geeks refer to as "the computer". Sometimes the commonly used phrase can be technically wrong and therefore misleading, despite the fact that it's popular.

      There's also a wider point at stake here: in general, we reserve the right to change the generally accepted meaning of words in the English language (presumably ditto for most other living languages) according to what most people understand them to mean. This typically does not happen in the same way within technical disciplines; physicists draw a distinction between "speed" and "velocity" and show no signs of changing. Usually what terms the techies appropriate to mean something very specific does not affect the rest of us - there's not much point in me labouring the distinction between monitor and computer with my friends, since the misunderstanding doesn't really hurt anyone. This is not the case for medical terminology, where the name of the disease tends to become a label for the sufferers in discussion, as well as a convenient way for a sufferer to explain their condition to an interested third party. The names of diseases have specific technical meanings to a Doctor but are often also used in everyday conversation between people explaining their health situation.

      Doctors aren't going to alter the names of diseases just because common usage often confuses a couple of them - it's technical jargon and there's no sense creating confusion in the medical community by changing that around. So it's up to the rest of us: do we want to stick the wrong label on an ill person because it's a generally accepted misunderstanding, or do we attempt to clarify the differences between disorders, knowing that a greater understanding and better use of the terminology is the only way the confusion will ever be resolved.

      I'm sticking with the latter approach since it raises public awareness of important issues, even though I know there will always be people who remain confused about the distinction.

    5. Re:So what is it? by dkleinsc · · Score: 1

      You meet a lot of crazy people in bars. One guy I saw in a bar said "I'd rather have a bottle in front of me than a frontal lobotomy".

      That line goes back a long way: It's attributed variously to Tom Waits (who definitely said it in the 70's), Dorothy Parker, and W.C. Fields.

      --
      I am officially gone from /. Long live http://www.soylentnews.com/
    6. Re:So what is it? by Hurricane78 · · Score: 1

      In a nutshell, schizophrenia is, when you stop accepting external factors for cause and effect, but start to make your own inner rules, which are detached from reality (the delusions), and act like this were the reality. They often think they would have some superhuman control over (their) "reality" too.

      It's most likely schizophrenia, when you can prove that there is no point in talking to them anymore, because all reason, logic, and association, is gone.

      They often argue in patters with faulty links. Like for example "The sun is yellow. Your shirt is yellow. Therefore your skin must be 5000 degrees Celsius, and I am not touching you!" This would go so far, that they would think they burned themselves, when accidentally touching you.

      The important thing is, to always see them as being just normal healthy people, except for this one flaw that has so big consequences. Don't abandon them. Because even if they will say, and truly (think they) believe that they will be very happy, being all alone... They, in their deepest hidden soul, will not be happy, but have huge pain that they can't release or heal because of that distortion of reality that "everything will be good". They will want you to care for them and receive love, even if they tell you that they will beat you up if you come close to them again. Because every human needs someone who cares for him/her. No exceptions.
      Leaving them abandoned, will make it much worse, adding a whole set of new distortions that also have to healed, but can't be fixed with meds(!!) anymore. (Because they are learned.)

      --
      Any sufficiently advanced intelligence is indistinguishable from stupidity.
    7. Re:So what is it? by Hurricane78 · · Score: 1

      I agree about the lobotomy.

      Essentially, after a lobotomy, the person you used to be, ceases to exist. It will be dead, if you want to see it that way.
      Of course you may want that person to die, because it is that horrible to be that person. But you want to keep the good aspects of yourself. And not lose all that which you value and love so much.

      A lobotomy is a horribly primitive method that should have stayed in the dark ages, where it belongs. A real healing can not be achieved trough just cutting parts away that do not work. They have to be fixed.
      But it is so easy to just cut it out. How convenient for the doctor. Less work. And the patient will not disturb you anymore. Because he will be happy if he even can speak afterwards.

      --
      Any sufficiently advanced intelligence is indistinguishable from stupidity.
    8. Re:So what is it? by Muad'Dave · · Score: 1

      "I'd rather have a bottle in front of me than a frontal lobotomy".

      Med students add the correct prefix to it:

      "I'd rather have a free bottle in front of me than a pre-frontal lobotomy".

      --
      Tiller's Rule: Never use a word in written form that you've only heard and never read. You will end up looking foolish.
    9. Re:So what is it? by Hatta · · Score: 1

      A real healing can not be achieved trough just cutting parts away that do not work.

      Depends on the problem. Many epileptics experience profound recovery after removal of parts of their temporal lobe. Frontal lobotomy is something entirely different of course, and yes, barbaric.

      --
      Give me Classic Slashdot or give me death!
    10. Re:So what is it? by Muad'Dave · · Score: 1
      Have you read the horrific account of Dr. Walter Freeman? To quote one of the articles below:

      The "ice pick lobotomy" was, according to Ole Enersen, performed by Freeman "with a recklessness bordering on lunacy, touring the country like a travelling evangelist. In most cases," Enersen continued, "this procedure was nothing more than a gross and unwarranted mutilation carried out by a self righteous zealot."

      The disgust I feel for this barbarism is intense; more intense than that for electroshock therapy as practiced in the 50's. Absolute barbarism. If this had happened in the 40's in Germany, it'd be treated as a crime against humanity. http://en.wikipedia.org/wiki/Lobotomy http://www.npr.org/templates/story/story.php?storyId=5014080 http://en.wikipedia.org/wiki/Walter_Freeman_(surgeon)

      --
      Tiller's Rule: Never use a word in written form that you've only heard and never read. You will end up looking foolish.
    11. Re:So what is it? by arekmenner · · Score: 2, Informative

      I'm going to agree here, please change the slashdot headline and summary to reference Bipolar Disorder instead of Manic Depression and Depression. I'm not going to go on a holy war about calling it Manic Depression, that's at least acceptable, but please DO NOT refer to it as it is in the summary, purely as Depression. When people say Depression (without the manic qualifier), they usually mean Major Depressive Disorder or Dysthymia, totally separate illnesses from Bipolar Disorder. It is mainly for this reason that the old Manic Depression term was dropped, because it made people perceive them as two separate parts of the same entity. There has NOT been found in this article a link between Major Depressive Disorder and Schizophrenia, but between Bipolar Disorder and Schizophrenia. If someone could, please change this to suit. Also, for more proof this is the right way to go, note that the first article linked does not, surveyed via Ctrl+f, reference Depression once.

    12. Re:So what is it? by ameoba · · Score: 1

      In a nutshell, schizophrenia is, when you stop accepting external factors for cause and effect, but start to make your own inner rules, which are detached from reality (the delusions), and act like this were the reality. They often think they would have some superhuman control over (their) "reality" too.

      It's sad to think that people can be so detached from reality. I pray for them.

      --
      my sig's at the bottom of the page.
  15. Manic Depression is awesome by grub · · Score: 5, Interesting


    When I on lithium (~15 years ago) I found my creative spark had gone. Sure, the window of emotion had narrowed considerably, but the super-fast mental edge was lost. That made me even more depressed when the time came. Spoke with my doc, dropped all the meds (but can get lithium if I become Superman again)

    If you can harness it, manic depression is wonderful thing.

    Posted non-anonymously because it's not embarrassing or a big stigma.

    --
    Trolling is a art,
    1. Re:Manic Depression is awesome by neowolf · · Score: 1

      This is interesting to hears, thanks. :)

    2. Re:Manic Depression is awesome by Xaedalus · · Score: 2, Interesting

      Kudos to you for posting w/ your name. I agree, IF you can harness it then yes, it can be a wonderful thing. The sticky point is being able to harness it.

      --
      Here's to hot beer, cold women, and Glaswegian kisses for all.
    3. Re:Manic Depression is awesome by Itninja · · Score: 1

      I can see how the mania would be potentially useful for harnessed. But the depression too? So when one wants to hang themselves in the garage or just stay in bad for days, how is that 'awesome'? Are you in a mania right now?

      --
      I judt got a nre Kinesis keybiartf so please excusr ant egregiou typos.
    4. Re:Manic Depression is awesome by grub · · Score: 3, Interesting


      The sticky point is being able to harness it.

      Yep, that's the kicker.

      When I spoke with the doc I told her my concerns. Things/answers/analysis/even jokes which would have come to me in a flash actually took mental work. Maybe it's parallel to how Alzheimer's patients start to feel, hope I never know.

      In any case, the high end isn't usually the problem, it's the bottoming out that comes. I take reasonable care of myself and overall it's worked out well. Hey, I've just had the past 15 years virtually med free. I shudder when the idea of Me taking all those meds during that time being just a functioning zombie.

      --
      Trolling is a art,
    5. Re:Manic Depression is awesome by Colourspace · · Score: 1

      Strangely enough I have just recently weaned myself off prozac after a six year period, and I too have got my emotional breadth and creative mojo back again. I'm sure it helped at the time I started but I feel a lot more like myself again now. For instance listening to certain music puts shivers down my spine again, whereas it had stopped affecting me like that for a long time.

    6. Re:Manic Depression is awesome by grub · · Score: 2, Insightful


      Are you in a mania right now?

      Nope. Remember that different people have different 'windows'. When the bottoming out came it was pretty shitty, slept all the time, would bawl my eyes out for no reason, etc. But I wasn't seriously suicidal.

      The past many years have had a few odd low ends but nothing as drastic as when I was in my late 20's. Part of the problem with the low end was self-medicating with booze or non-pharm drugs. Nowadays if I feel even remotely bummed out I won't touch a drop of booze, it may not make things necessarily rosey right away but it won't lower me further into the pit.

      --
      Trolling is a art,
    7. Re:Manic Depression is awesome by WilyCoder · · Score: 1

      Hell yeah! I was on a regimen of Sam-E in college. It put me into a hypomanic state. It was the best time of my life! I was sleeping 6 hours a night, full of energy, and wanted nothing more than to fuck all the college girls I saw. Very different from my usual bored apathetic state :D

    8. Re:Manic Depression is awesome by BadAnalogyGuy · · Score: 4, Interesting

      Not to be glib, but couldn't it just be part of the disease to feel that the medicated state is unnatural? Whereas you feel muted when on the medicine, it is actually the way most people feel all the time?

    9. Re:Manic Depression is awesome by Red+Flayer · · Score: 1

      by grub (11606)

      Posted non-anonymously because it's not embarrassing or a big stigma.

      I applaud your courage, but I find it humorous that you feel you are posting non-anonymously when using an anonymous pseudonym.

      I know there's a lot of truth to the fact that our online personas, in the context of online interactions, are an analogue to our meatspace personas, and we have a sense of identity with them that is really not much different (if it differs at all) from our meatspace identities.

      But it still makes me chuckle.

      --
      "Trolls they were, but filled with the evil will of their master: a fell race..." -- J.R.R. Tolkien on Olog-hai
    10. Re:Manic Depression is awesome by grub · · Score: 1
      Hmmm... Better post "Small Print":

      Do not alter your medication before discussing it with your physician. If you are having suicidal thoughts, call your physician immediately. Do not take comments on slashdot as medical advice. YMMV

      There :)

      .

      --
      Trolling is a art,
    11. Re:Manic Depression is awesome by Aphoxema · · Score: 1

      The only thing I harnessed with my highs was fist fighting and acting like a tool and the only thing I harnessed from my lows is excessive sleep and suicidal tendencies.

      Apparently it's a YMMV thing.

      --
      "Most people, I think, don't even know what a rootkit is, so why should they care about it?"
    12. Re:Manic Depression is awesome by grub · · Score: 1


      Do a whois on the domain in my always non-obfuscated email address. I'm the farthest thing from anonymous.

      --
      Trolling is a art,
    13. Re:Manic Depression is awesome by Anonymous Coward · · Score: 0

      The significant element that is common to Rivera, Siqueros, Picasso, Pollock, Van Gogh and Frida Kahlo is the expression of pain. (Bill Cannon)

    14. Re:Manic Depression is awesome by Red+Flayer · · Score: 1

      Well, then, I stand corrected. My apologies.

      You bastard. You've just made me lose a chuckle.

      Thank you for making my day that much worse. :(

      --
      "Trolls they were, but filled with the evil will of their master: a fell race..." -- J.R.R. Tolkien on Olog-hai
    15. Re:Manic Depression is awesome by ae1294 · · Score: 2, Funny

      it is actually the way most people feel all the time?

      and he should really care how "normal" people fell why????

      fuck normal... give me bat shit crazy and totally happy any day....

    16. Re:Manic Depression is awesome by grub · · Score: 2, Funny


      heh heh heh, don't get all depressed over it. Life's too short... :P

      .

      --
      Trolling is a art,
    17. Re:Manic Depression is awesome by Ethanol-fueled · · Score: 1

      I've been on antipsychotic meds. If that's the way most people feel all of the time then they're a bunch of idiot zombies who can't think for themselves, as they drift from day to day across a pointless existence. Oh, wait ;)

      Many folks believe they are crazy because they feel outside of normalcy. Fuck normalcy. I'll take idiosyncracies and...gasp...a personality over being "normal" anyday.

    18. Re:Manic Depression is awesome by that+IT+girl · · Score: 1

      This sounds a lot like me, actually. I do not think I am manic depressive, though if I am it's a very mild case. I have amazing highs and then horrible lows where I can hardly stop thinking of suicide in great detail. However, I wouldn't give it up for *anything*. Most of my favourite art, and ALL the works (poems, pencil drawings, and paintings) I ever sold were created during the low state. I think most great artists had this "problem", as you hear about the crazy things they did, or the alcohol problems they had, and etc. It's like one of those super powers that comes with its own downside or consequence.

      --
      10 FILL MUG WITH COFFEE
      20 DRINK COFFEE
      30 GOTO 10
    19. Re:Manic Depression is awesome by linhares · · Score: 1
      must conform...

      must conform to society...

    20. Re:Manic Depression is awesome by arb+phd+slp · · Score: 1

      Mania can be just as dangerous as depression, especially since depression doesn't always lead to suicidal thoughts. I used to work at a rehab for people with traumatic brain injuries and behavior impairments and we had a lot of people who got their brain injury because they were in a manic phase and did something really crazy and got hurt.
      Bipolar disorder can be tough with an intact frontal lobe. With a damaged frontal lobe, you're not going to be "harnessing" anything.

      --
      There's a perfect xkcd for my sig but I'm too lazy to look it up. sudo someone go find it.
    21. Re:Manic Depression is awesome by geminidomino · · Score: 2, Interesting

      I envy you then.

      While mania makes me a lot more productive, since I don't sleep but 2-3 hours a night for a few weeks, it's not really worth it. My mind starts going so fast, I get dysphasic and develop a stutter, become even more ornery than I normally am because they're interrupting my brilliant works (even something as trivial as tweaking my mythbox's remote settings), and spend way too much money.

      But nothing is as bad as the mixed episodes... Being depressed enough to off oneself at the same time as being hyper and judgement-impaired to actually start going through with it... that is some scary shit...

    22. Re:Manic Depression is awesome by Have+Brain+Will+Rent · · Score: 1

      Like lithium I think that a lot of the anti-depressants, perhaps most or even all, aren't so much anti-depressants as they are mood stabilizers. They act to compress your emotional range... they so no more big lows, but also no more big highs either... life becomes less sad but it also becomes less joyful. Better than ending up suicidal but a poor solution at best.

      And I agree, mental health issues should not be embarrassing or a stigma any more than is a malfunctioning bile duct or arthritis. Unfortunately they still are a magnet for discrimination of all sorts. So good for you for being non-anonymous.

      --
      The tyrant will always find a pretext for his tyranny - Aesop
    23. Re:Manic Depression is awesome by ColdWetDog · · Score: 3, Informative

      Not to be glib, but couldn't it just be part of the disease to feel that the medicated state is unnatural? Whereas you feel muted when on the medicine, it is actually the way most people feel all the time?

      Well, the medicated state is unnatural. And there are certainly people who feel 'muted' much of the time and the tolerance to mood swings is quite varied among folks. Lots of bipolar patients like the "up" when the can handle it. Everybody seems to hate the down part and it can be rough to cycle up and down quite a bit. The differences between monopolar (clincal, classical, typical depression) and bipolar disease aren't all that great and there is no strict line between "normal" and a "disease" state. Sometimes it's really obvious and much of the time it isn't.

      IMHO (and IAAMD) the term "antidepressant" is a big misnomer. They are really mood stabilizers, ala lithium. They do flatten both the ups and downs and they do interfere with creative energy and ability. If you look at the personal lives of many creative people, both in the sciences and arts and in fact in much of the religious sphere, you can discern clear DSM-IV diagnoses. They are 'mentally ill' by our current definitions. And if you look at their often short lived, self destructive lifestyles it's easy to believe that.

      There currently is no such thing as a free lunch when it comes to neuropsychiatric drugs - they're really more like hand grenades then rifle bullets. They hit the target, but often cause collateral damage. Whether and how much and what you should take is often a long term, complicated dance between the patient, the physician and occasionally the courts.

      --
      Faster! Faster! Faster would be better!
    24. Re:Manic Depression is awesome by Anonymous Coward · · Score: 0

      Nope. My doctor offered me a choice: I could take lithium, which would make me closer to 'normal', or I could take lamotrigine (which wasn't approved until a few years ago) and be a functional hypomanic. I chose the lamotrigine, and now I'm getting the best of both worlds.

    25. Re:Manic Depression is awesome by Anonymous Coward · · Score: 0

      same story here- only less thn 2 years ago- i agree- it's awesome

    26. Re:Manic Depression is awesome by Anonymous Coward · · Score: 0

      You make a very good point. Many of highly talented scientists suffered from these conditions; for example Norbert Wiener suffered from depression, Newton is suspected to have suffered from schizophrenia, and John Nash is schizophrenic as well. As you said, the mental edge is lost when using medication. As breakthroughs in math and other fields require mental superpowers, I really hope that not everyone who has the slightest symptoms is put on medication..

    27. Re:Manic Depression is awesome by DrgnDancer · · Score: 1

      I think a lot probably depends on how far out "normal" your moods swing. If your lows are so low that you, say, regularly contemplate suicide over running out of orange juice (a silly extreme I admit, but you get the picture) you probably have little choice but to stabilize your moods chemically.

      --
      I don't need a million points of light, just two points of multi-mode fiber and a 10 Gig-E router.
    28. Re:Manic Depression is awesome by Jeppe+Salvesen · · Score: 1

      There currently is no such thing as a free lunch when it comes to neuropsychiatric drugs - they're really more like hand grenades then rifle bullets. They hit the target, but often cause collateral damage. Whether and how much and what you should take is often a long term, complicated dance between the patient, the physician and occasionally the courts.

      We've lost parts of the secret of living happily with our flaws. Instead of accepting reasonable imperfections in ourselves and others, we strive towards whatever bullshit ideals we have and most of us fail to reach them. We are vastly overmedicated to compensate for our lack of wisdom and knowledge of living.

      Then again, some people genuinely need these drugs - either temporarily or on a permanent basis. But I cannot believe so many of us have brains that need chemical help to function adequately.

      --

      Stop the brainwash

    29. Re:Manic Depression is awesome by Colourspace · · Score: 1

      Well, you all have valid points. But what I would agree with the most is the stabiliser part. I no longer (well for now at least) seem to have the bad mood swings I had six years ago. The prozac *seems* to have clamped them down, but also clamped down normal feelings. Without the prozac I am finding myself enjoying life again, without the absolute highs and the dreadful lows. YMMV.

    30. Re:Manic Depression is awesome by david_thornley · · Score: 1

      FWIW, my personal, subjective, anecdotal experience of antidepressants is that they provide a floor. They don't appear to me to interfere with creativity (based on stuff I produced with and without - although it's certainly arguable that the antidepressants suppress creativity as much as depression does), and I have more energy when I'm not depressed no matter how that happens.

      On the other hand, it beats depression. Insisting on keeping people depressed to improve their creative output strikes me as torture. I'd rather wait for a beautiful painting, great book, or proof as to whether P=NP than torture it out of somebody.

      --
      "When you have eliminated the unacceptable, whatever is left, however improbable, must be the truthiness" - Holmes
    31. Re:Manic Depression is awesome by winomonkey · · Score: 1

      I had the pleasure (and I do say this with complete sincerity) of dating a girl back in college who was suffering from bipolar disorder. She was a photographer and a "crafter" by nature, and her manic periods were full of photography, knitting, etc. Unfortunately, she was not all that able to capture her depressive states (which I feel that you incorrectly overgeneralize as being suicidal), and so did not have the chance to funnel her sadness into new art. She had the low days quite a bit (made worse by medication that was targeted at depression instead of bipolar disorder, which cause rapid cycling of her emotional state). I have met other people who were a little better at channeling their depressed states and made some really beautiful art. A lot of creative drive can come from reflecting upon the sad times (why is so much music made around breaking up, loss, death, sadness, etc?), and those who can experience the wider rage of emotions more constantly can better capture them. One of the problems, though, is that many people in the depressive state are upset by very small things - a song about how "my roommate left a damp towel on the bathroom floor and a dish in the sink and then the bus was five minutes late and I didn't want it to be five minutes late" might not be as gripping to the listener as it was to the person who happened to be depressed that day. Oh yeah, and the above was an actual exchange that was made over the phone on one of her bad mornings.

    32. Re:Manic Depression is awesome by Anonymous Coward · · Score: 0

      Ditto experience for me. First reaction from people close to me was that I seemed slow or dull. I suddenly couldn't do math like I used to.

      Saw some interesting studies linking depression to swelling of the hippocampus (iirc), a part of brain also used for geospatial and (some) logical reasoning.

      Other side effect: loss of sexual interest.

    33. Re:Manic Depression is awesome by PCM2 · · Score: 1

      Things/answers/analysis/even jokes which would have come to me in a flash actually took mental work.

      Funny, that's something that's happened to me when I've smoked weed. No joke, it scared the hell out of me.

      --
      Breakfast served all day!
    34. Re:Manic Depression is awesome by Anonymous Coward · · Score: 0

      If you can harness it, manic depression is wonderful thing.

      Sure it's fun to harness until the mania's gone and I'm swinging hard in the other direction. Then it takes all I can give for months on end to try and forget everything, especially how bad I feel. After life has become a barren wasteland with no purpose to it whatsoever, one day I wake up and remember why life is so important and I can't seem to recall why I ever felt bad to begin with.

      I feel ya on ditching the meds though, tried them and they worked but they took away everything that made me feel like me. I know if things swing south for too long I can always go back to them for help.

      Posted anonymously not out of shame or stigma, but I fear talking about these things could bar me from a really good job one day.

    35. Re:Manic Depression is awesome by moredrivel · · Score: 1

      Glad it's working for you. I have a close friend on a similar track. She has difficulties at times, but manages it and prefers the full spectrum over the duller edges.

      I think one of our weaknesses as a society is our insistence on defining and trying to be "normal." In so doing, we also define "abnormal" and thus limit our perception and understanding of the natural world.

    36. Re:Manic Depression is awesome by tgeller · · Score: 1

      You're confusing "abnormal" with "unnatural".

      Without meds the OP was abnormal, but also by definition completely "natural".

      The question is: Which is the better way for the OP to live? That's his/her decision.

      --
      Tom Geller
    37. Re:Manic Depression is awesome by Anonymous Coward · · Score: 0

      What "they" call mental illness we call the dawning of a person's consciousness attempting to assert itself above the 'norm' thus they must convince and drug them to 'cure' them of their personal revelation rising above the psychological shackles they have realised society has placed over them. The sheep want to keep sheep, sheep. They don't want self-aware individuals roaming the Earth as it would actually lead to a populace that 'gets it' when it comes to reality.

    38. Re:Manic Depression is awesome by ConceptJunkie · · Score: 1

      I'm glad you got that back. I've been on Effexor for about 9 years and I haven't lost that. If I had, I would be really worried and consider getting off the meds. I'd like to get off the meds, but they really help.

      My creative mojo, my mental energy, my appreciation for music (I'm a lifelong music lover) have not diminished as far as I can tell. I do as much or more creative stuff now than I did at any time since about 1994 and I'm as rampant a music nut as I ever was. But the former is probably not so much a function of the meds but a function of when my first child was born. With four kids you go into about a 10-year pattern of having very little focus other than kids and work. It's still very fun and very rewarding, but it doesn't leave as much time for other things. Now that the kids are older and don't require anywhere near as much close supervision I can pursue other interests better, which has another side effect, because a lot of these interests spill over to the kids.

      I've heard many people describe that side effect and I try to monitor for it in myself. I haven't seen any kind of lack of affect or creativity, which is good, because that's a big part of what I feel makes me me! Occasionally I forget the meds and have found that after about 48 hours, the biggest thing I notice is that my potential for anxiety goes way up.

      I hope things continue to go well for you.

      --
      You are in a maze of twisty little passages, all alike.
    39. Re:Manic Depression is awesome by tbuskey · · Score: 2, Insightful

      Well, the medicated state is unnatural.

      I can agree with you there.

      IMHO (and IAAMD) the term "antidepressant" is a big misnomer. They are really mood stabilizers, ala lithium. They do flatten both the ups and downs and they do interfere with creative energy and ability.

      I've been suffering from clinical depression for over 10 years. I've tried a number of different medications due to side effects and the meds no longer working. Now this is for depression, not bipolar so I might be way off from what you're talking about.

      I mainly experience the meds making it possible to be happy. With the depression, it just doesn't seem possible. But I haven't had problems with my creative energy or ability while on the meds.

      Without the meds, I have no creative ability so there's no peak. With the meds, its possible to have a peak.

    40. Re:Manic Depression is awesome by curunir · · Score: 2, Interesting

      But I cannot believe so many of us have brains that need chemical help to function adequately.

      I don't think it's that people need these drugs to function adequately, I think it's more of a coping mechanism for a lifestyle that we're just not well adapted to. Our society is so overstimulated that many people can't cope with it over long periods of time. For many people, this results in a constant level of stress. And not the touchy-feely stress that people talk about, stress that directly leads to the release of certain chemicals, like adrenaline, in our bodies that are intended for short-term use in survival situations.

      My personal belief is that the majority of the people on anti-depressants would get better if they could remove as many of the stress-causing elements of their lives. For example, ditch the cell phone, TV and limit yourself to only a couple of hours in front of a computer each day (including work), and I think a lot of people would find they don't need the drugs. Unfortunately, these kinds of lifestyle changes just aren't feasible for most people so the drugs end up being used as the coping mechanism.

      So I agree with you that most people do not need these drugs in an absolute sense, but I do believe that so many people need them in the context of the lives they're living.

      --
      "Don't blame me, I voted for Kodos!"
    41. Re:Manic Depression is awesome by Anonymous Coward · · Score: 0

      Lithium should not have been considered a long term medication unless it was absolutely necessary: kidney damage. See wiki.

    42. Re:Manic Depression is awesome by Anonymous Coward · · Score: 0

      When I on lithium (~15 years ago) I found my creative spark had gone. Sure, the window of emotion had narrowed considerably, but the super-fast mental edge was lost. That made me even more depressed when the time came. Spoke with my doc, dropped all the meds (but can get lithium if I become Superman again)

      If you can harness it, manic depression is wonderful thing.

      Posted non-anonymously because it's not embarrassing or a big stigma.

      As a psychiatrist, I see many people with Bipolar Disorder on a daily basis. Many individuals express a similar sentiment. The problem is that a single manic episode MAY ruin part/all of your life (e.g. sending your money to those pesky Nigerians who's emails sound a whole lot more reasonable all of the sudden). Episodes tend to be infrequent early in life (average time between 1st and 2nd manic episode ~10 years), but often increase in frequency over time. A person in a manic state may be increasingly productive and creative, and many past artistic greats are thought to have had bipolar. However the impact of the manic episodes on the individual plus the depressive episodes (which there are ~20 for every manic episode) frequently drain the person and their loved ones. Their mania may benefit society by great works of art at the cost of the individual. By no means is this universal, but I see too often lives ruined from this disease. As for lithium, the newer atypical antipsychotics often work equally well and are much less likely to cause cognitive dulling.

    43. Re:Manic Depression is awesome by Anonymous Coward · · Score: 0

      I have met other people who were a little better at channeling their depressed states and made some really beautiful art.

      This is likely due to the differences between people's depressions rather than their ability or willingness to apply their condition to an art. Too often, people who have never experienced depression try to understand the condition based on their own experiences. And the closest approximation to the disease is sadness. But for many people with depression, it's very different from sadness. Some patients lose the ability to feel highs or lows and can't feel happy or sad. Some patients feel chronically sleepy or low energy. And there are many more ways that depression can manifest itself. Those whose depressions manifest themselves in true sadness may be able to channel that sadness into art, but for many, there's just nothing to channel. And, worse yet, many depressives have difficulty concentrating for extended periods of time, which makes it that much harder to produce anything of value when you're in that state.

      The term depression is almost too accessible to the general public and can be counterproductive to any discussion of the people suffering from it. It leads people who haven't experienced it to try to understand it in a way that they're just not capable of. It's a bit like love in that way...the closest approximation to love is happiness, but most people will tell you that love is very different from happiness and has qualities that just can't be described, they have to be experienced. But by trying to relate to it in this way, it leads to people overgeneralizing what depression is when the reality is that almost all depressions are somewhat unique...they may share common characteristics, but the experience is almost never the same.

      I'm not trying to harp on a single sentence from your post and infer that you don't understand depression from it, I'm just using your wording to express something that might help others who don't understand it gain a bit more perspective. Because as someone who's been through it, the quoted sentence is better phrased as, "I've met some people who's depressions were beneficial to their art" since some forms of depression just don't lend themselves being expressed in a way that helps the creative process.

    44. Re:Manic Depression is awesome by Colourspace · · Score: 1

      As ever, with any subject, its easy for someone who has never experienced something for themselves to have an opinion that is not entirely informed. I can say, sadly, with some confidence this has happened throughout this entire forum.

    45. Re:Manic Depression is awesome by Anonymous Coward · · Score: 0

      Now how to swing in the other direction? Something opposite to lithium?

    46. Re:Manic Depression is awesome by marty23571113 · · Score: 1

      If you know how to harness HYPO manic energy with going over the line to true MANIC energy (which you must be referring to as MANIC energy is totally unfocused - with the possible exception of sex) - please share this secret. As the saying goes "many have tried and many have failed". Harness such energy could be potentially game changing for the race.

    47. Re:Manic Depression is awesome by Optimus6128 · · Score: 1

      Interesting example.

      Sometimes you come into this world and it just happens to have a different brain chemistry than most other people. This might create conflicts or confuse people who aren't hanging regularly with people like you. Because they expect the usual norms and attitude that they are used to from common people. Yet, the notion of "disorder" means really that and the incompatibility. There is not a disorder really, just neurodiversity. The only thing that remains is to find who we really are (and how differently our brain works than the norm) and find a ballance between our different state and the general population.

      --
      The "H-Word" has died for me.
    48. Re:Manic Depression is awesome by Optimus6128 · · Score: 1

      An interesting question too. Although to me this would mean that "normal" is subjective.

      Well, someone would say "Ok,. follow the 'normal' that most people accept as that!". But why would someone like to do that when it's incompatible with his brain state and personality? At the end of this I have decided that it stopped making sense to me and all I can do is try to be myself (or actually not try, just let it come naturally) and if this brings misunderstanding, conflict or argument with the common people then in the meanwhile we can try to find some kind of solution (a middle one?)

      Or, I simply stopped caring about 'normal'.

      --
      The "H-Word" has died for me.
    49. Re:Manic Depression is awesome by dickens · · Score: 1

      pity you can't bottle that stuff, and take it in small doses...

    50. Re:Manic Depression is awesome by Anonymous Coward · · Score: 0

      Low-dose lithium as an adjunct has been extremely effective in my case. Lamotrigine as primary medication, 600 mg bid lithium, takes an edge off the mind, allows for a reasonable degree of creativity, and seems to limit the severity of depressive episodes so far. Lithium as a primary medication is much different, requires more monitoring, and more risk of complications.

  16. Depression vs. Bipolar by david_thornley · · Score: 4, Informative

    The summary seems to confuse being depressive with being bipolar (i.e., manic-depressive). Clinical depression is a common problem, and is generally treatable to some extent with drug and cognitive therapy. Last I checked, bipolar was much less common and a lot less treatable.

    So, it isn't going to lead to new treatments for two common problems. It may well lead to new treatments for two problems, one of which is distinctly less common. Those who are clinically depressed but not bipolar may well not benefit at all.

    --
    "When you have eliminated the unacceptable, whatever is left, however improbable, must be the truthiness" - Holmes
  17. Nice to see the worst elements of /. are here by NoNeeeed · · Score: 3, Insightful

    With three comments, this article has already been tagged with "nutjobs".

    Grow up. Chances are you know someone who has (or will develop) one of these conditions to some degree, even if you don't know it (which is likely if you are that much of a jackass, they probably wouldn't tell you).

    I don't normally do angry rants, but sometimes I'm surprised by the juvenile and compassionless attitudes of some people on /.

    1. Re:Nice to see the worst elements of /. are here by geekoid · · Score: 4, Funny

      That was your angry rant? Man, you need some practice~

      --
      The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
    2. Re:Nice to see the worst elements of /. are here by ihatewinXP · · Score: 1

      People that feel the need to shout that sort of nonsense probably have something going on themselves....

      --
      ---- The real Slashdot is still here. You just have to browse at -1 to read the comments.
    3. Re:Nice to see the worst elements of /. are here by xednieht · · Score: 3, Funny

      Since one of the symptoms is "purposeless agitation" it would seem that /. is a schizo-magnet.
      Not me of course since the voices told me I wasn't.

      --

      Hope is the currency of fools
    4. Re:Nice to see the worst elements of /. are here by religious+freak · · Score: 1

      I don't normally do angry rants, but sometimes I'm surprised by the juvenile and compassionless attitudes of some people on /.

      I'd really love to know the average age of the typical /. reader. There are brilliant minds here, for sure, but I agree with you that some comments (outside of just this one story) and overall community attitudes are lacking in maturity. I largely hope these attitudes are held by kids - smart kids, but kids nonetheless.

      --
      If you can read this... 01110101 01110010 00100000 01100001 00100000 01100111 01100101 01100101 01101011
    5. Re:Nice to see the worst elements of /. are here by Anonymous Coward · · Score: 0

      Or the people who feel the need to point it out to others, with their own insecurity. ...wait...

    6. Re:Nice to see the worst elements of /. are here by Em+Emalb · · Score: 1

      LOL, get back in the house, old man, the grass is no place for you.

      You can't stop here, this is kid country.

      (I'm in my mid-30's...but I act like a jackass...erm kid still.)

      --
      Sent from your iPad.
    7. Re:Nice to see the worst elements of /. are here by fuzzyfuzzyfungus · · Score: 1

      Taking mental illness seriously basically means admitting that "you" are chemical meat first and "willpower", "soul", or whatever only secondarily, if at all. That isn't what I'd call a wildly popular idea, so it isn't a huge surprise that almost any research on the biology of mental illness would draw some flack and immaturity.

    8. Re:Nice to see the worst elements of /. are here by Maxo-Texas · · Score: 4, Funny

      He would probably give an angrier rant if not for the meds.

      --
      She was like chocolate when she drank... semi-sweet at first and then increasingly bitter.
    9. Re:Nice to see the worst elements of /. are here by Anonymous Coward · · Score: 0

      actually it is a bit nice.

      as someone who's been diagnosed with schizophrenia; one of the biggest realisations that helps is that it's not so much people are out to get me but more people our just out to get anyone.

      i just happen to be a bit over sensitive is all. then it just becomes important to remember that.

      thanks for the reminder assholes :-)

    10. Re:Nice to see the worst elements of /. are here by Aphoxema · · Score: 1

      I'm 25 and I try my damnedest to be on my best behavior.

      --
      "Most people, I think, don't even know what a rootkit is, so why should they care about it?"
    11. Re:Nice to see the worst elements of /. are here by Locke2005 · · Score: 1

      I don't normally do angry rants Glad to hear the meds are working (most of the time)...

      --
      I've abandoned my search for truth; now I'm just looking for some useful delusions.
    12. Re:Nice to see the worst elements of /. are here by networkconsultant · · Score: 1

      what you hear voices, I see people! They keep asking me to do things for them....

    13. Re:Nice to see the worst elements of /. are here by Hurricane78 · · Score: 1, Flamebait

      Exactly. One should note, that being religious essentially is a light schizophrenia. (Usually noting too bad though.) You can notice the extreme similarity in their behavior. (Being detached from reality. Using an inner reality, and basing cause and effect on it. Being unable to be reasonable or having huge lapses in logic and associations.)

      I know that this will offend all religious people. And by definition they will not be able to accept that.
      So I am sorry. But I just say it how it is. This does not mean I do not respect them or think they are worse humans. I value all humans equally. Period. :)

      --
      Any sufficiently advanced intelligence is indistinguishable from stupidity.
    14. Re:Nice to see the worst elements of /. are here by Rycross · · Score: 1

      I value all humans equally. Period. :)

      Even Hitler?

      /Godwinned

    15. Re:Nice to see the worst elements of /. are here by Anonymous Coward · · Score: 0

      Dude you tried to write an angry rant cause some random people tagged the story nutjobs? Yeah it's silly but chill out.

    16. Re:Nice to see the worst elements of /. are here by TheLink · · Score: 1

      Personally I haven't seen any human without huge lapses in logic. Even atheists.

      FWIW most people in general are detached from reality[1].

      For example watch the following video and count the total number of times that the people wearing white pass the basketball. Do not count the passes made by the people wearing black:

      http://viscog.beckman.illinois.edu/flashmovie/15.php

      [1] Many wouldn't even see a gorilla in a video waving at them, because they are so busy with more important matters. Go figure.

      --
    17. Re:Nice to see the worst elements of /. are here by Anonymous Coward · · Score: 0

      Or maybe you can grow a pair and learn to act intelligently without doping yourself up on the next miracle med.

    18. Re:Nice to see the worst elements of /. are here by Hurricane78 · · Score: 1

      Yes. Even Hitler. Because I am looking at the whys and hows of his life, and all I can see, is another human with some bad things that made him what he was.

      --
      Any sufficiently advanced intelligence is indistinguishable from stupidity.
    19. Re:Nice to see the worst elements of /. are here by gestalt_n_pepper · · Score: 1

      But at least they pay you.

      --
      Please do not read this sig. Thank you.
    20. Re:Nice to see the worst elements of /. are here by aqk · · Score: 0

      Nice to see the best elements of /. are here
      There- corrected it for ya...

      Hey, ladies- I've had friends and acquaintances die from schizophrenia. (the usual self-administered way)
      And- I suffer from clinical depression.
      And- I am a kid at heart, but chronologically 68 years old.
      Agreed, many of the comments are in "bad" taste, but funny, nevertheless. If you cannot laugh at this shit, then GTF off of slashdot.
      The rest of you guys? Thanx fer cheering me up.
      Try laughing at death sometime. But ladies, you're probably too "mature".

  18. All those making jokes... by Anonymous Coward · · Score: 0

    Schizophrenia is not the same as dissociative identity disorder. It means split mind, not split personality. BUT don't feel too bad, ignorance about mental disorders is normal.

    Also, schizophrenics are less likely to be violent than a person without Schizophrenia, except against themselves. Schizophrenics' suicide rate is 1 in 10.

  19. Re:Need to slow down when reading the article titl by neowolf · · Score: 4, Insightful

    The title is a bit misleading. There is a big difference between Depression and Bipolar/Manic-Depressive disorders.

  20. that's absurd by Anonymous Coward · · Score: 0

    you're just hearing things...

  21. Important findings by Cluster2k1 · · Score: 2, Interesting

    Anything that sheds new light onto Schizophrenia and related disorders is very welcome. It's heart breaking to watch someone close to you go through Schizophrenia symptoms. It's not the funny Hollywood version of split personalities. People suffering the disorder believe they are incredibly important (on a world scale), that they're on a special mission, they're related to Jesus, that others are coming to commit harm. Most of all, they can't tell you who sent them on the 'mission' or why. They sometimes turn on friends and accuse them of literally giving the disease. The paranoia accompanying the illness can reach critical levels. Saddest of all, a person with Schizophrenia does not believe they have a problem. They believe everyone else is either wrong, out to get them, or 'just doesn't understand.' Getting a sufferer to realise anything is wrong, let alone getting them to accept medical treatment is a real trial.

    1. Re:Important findings by linhares · · Score: 1

      So that's religion, in sum?

    2. Re:Important findings by Jellybob · · Score: 1

      So very true, my fiance suffers from manic depression, with occasional paranoia, and it's terrifying when it happens. Obviously not enough to stop me marrying her, but still very scary.

      Usually she's absolutely fine, and you wouldn't be able to tell if you didn't know, but every now and then something completely off the wall will happen. Recently I was going to sleep, when I noticed that she was sitting at the end of the bed crying. Turns out she was trying not to go to sleep, because she needed to stand guard in case anything happened in the night. Thankfully it's very rare, and usually there are other things which trigger it (in this case that we've just moved into a new house), but I'm still incredibly happy to see some progress being made to treating it more effectively.

    3. Re:Important findings by Anonymous Coward · · Score: 0

      and that they invented the iPhone. (And Apple II)

  22. Re:Need to slow down when reading the article titl by geekoid · · Score: 3, Insightful

    Awesome. I have saidf for a while that will be the killer app for future devices. uilt in achievments, as well as achievements that can be added.

    Achievement unlocked! you ahve walked 1,000,000 steps.
    Achievement unlocked! You have run a 10 minute mile! next achievement, 8 minute mile.

    You have listened to your 10000 th minute of music.

    And so on.

    --
    The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
  23. This is what is being done now... by bogaboga · · Score: 2, Informative

    In order to treat these conditions, ECT is the tool of choice these days. It has its own detractors (me inclusive) for I do not see how inducing a seizure helps an individual.

    Worst of all you could lose all your memory. There was a story of a lady who did not remember anything about her clothes and wondered who had put "foreign" clothes in her closet. In another case, a former doctor could not remember who the hell he was after the procedure. Scary indeed.

    1. Re:This is what is being done now... by DocJohn · · Score: 1

      ECT is not the "tool of choice these days" to treat schizophrenia or bipolar disorder. If I had mod points, I'd mod this one down.

      ECT is used -- rarely -- to treat major depression. And in a few years, when ECT manufacturers will be required to submit actual research proof of this technique's safety and efficacy, I imagine ECT may not be an option for clinical depression long.

    2. Re:This is what is being done now... by mcgrew · · Score: 1

      ECT, Electro-Convulsive Therapy, also often called "electrical lobotomy".

    3. Re:This is what is being done now... by Anonymous Coward · · Score: 0

      ECT is a good example of why "psychiatry" is NOT a branch of science, but rather pseudo-science like chiropractic.

      It was discovered that after having a seizure, people became docile and tended to have an upbeat mood.

      So, some psychiatrist got the bright idea of shocking the fuck out of depressed and schizophrenic people. The electrocution produced seizures, and afterwards the patients were docile and had an upbeat mood (just ask 'em! "Do you feel as though you have an upbeat mood, or should I shock the fuck out of you again?").

      The way Psychiatry is pursued is absolutely ridiculous. They're experimenting with people's BRAINS here. They have no business monkeying around in there; they're barely competent to do so. No honest psychiatrist will claim that he really understands how the brain works. Yet they regularly deliberately alter brain chemistry and "see what happens".

      Do you know what "Let's see what happens" means? It means "If this drug doesn't make you act normal, we'll use another one on you, until you're either A) happy, B) a vegetable, or C) A little of A, a little of B".

      The whole thing ought to be stopped.

      As my final, irrefutable condemnation of psychiatry, I would like to point out that in the first half of the 20th century, tens of thousands of patients had their brains' frontal lobes DELIBERATELY DESTROYED WITHOUT ANESTHESIA by psychiatrists who felt it was easier to care for vegetables than active, thinking patients.

      The WHOLE GOAL was to make the psychiatric staff's jobs easier.

      They went straight from lobotomizing monkeys to performing this horrible operation on humans.

      How many good people were destroyed during this period?

      How many eccentrics -- that's YOU, slashdotters -- had their minds destroyed?

      Psychiatry is evil.

    4. Re:This is what is being done now... by jtev · · Score: 1

      ECT is not the "Tool of Choice" to treat anything. It's a very efective too, but it's also the tool of last resort. It is unknown why the seizures correct mental health disorders, only that they do. The fact that there are very bad side effects mean that it is not used except where other treatments have already failed.

      --
      That which is done from love exists beyond good and evil
    5. Re:This is what is being done now... by Have+Brain+Will+Rent · · Score: 1

      I don't know about its use with manic depression or schizophrenia but ECT is not the tool of choice for chronic depression. It is sometimes used in cases of severe depression that are drug and therapy resistant. In those cases it is more or less ECT or depression which may lead to suicide. And apparently it frequently does completely do away with the depression,and produces the negative effects you mention, but only lasts about 6 months and has to be repeated.

      --
      The tyrant will always find a pretext for his tyranny - Aesop
    6. Re:This is what is being done now... by networkconsultant · · Score: 1

      ECT is idoitic moronic and just plain stupid. It's like stating that frying an egg will help it grow into a chick. ECT is good if you are a violent sociopath, then again so is a frontal labodamy. ECT should be illegal in all countries. Your neural tissue was never designed to deal with that kind of shock.

    7. Re:This is what is being done now... by Anonymous Coward · · Score: 1, Informative

      From your link:

      "There is considerable variability among practitioners in the frequency with which ECT is used as first-line/primary treatment or is only considered for secondary use after patients have not responded to other interventions.

      The APA 2001 guidelines give the primary indications for ECT among patients with depression as a lack of a response to, or intolerance of, antidepressant medications; a good response to previous ECT; and the need for a rapid and definitive response (e.g. because of psychosis or a risk of suicide)."

      Further:

      "The 2001 APA ECT guidelines say that ECT is rarely used as a first-line treatment for schizophrenia but is considered after unsuccessful treatment with antipsychotic medication, and may also be considered in the treatment of patients with schizoaffective or schizophreniform disorder. The 2003 NICE ECT guidelines do not recommend ECT for Schizophrenia."

      So, basically, yes, ECT is a treatment that is used, but generally only for people who really need treatment (mostly because of suicide risk) and don't respond to the first choices, which are usually anti-depressant / anti-psychotic medications. It's not something most practitioners leap to, unless they're extremely behind the times. Anti-psychiatry groups (like the Church of Scientology) like to grab onto ECT as an example of the horrors of treatment, because it does carry some severe drawbacks, and they tend to inflate ideas about how prevalent it is.

      Side note: One of my best friends growing up had a severe case of treatment-resistant bipolar disorder, and his doctors tried all sorts of things, Lithium, other drugs, but never ECT, even though his other treatments were less than helpful.

      Second side note: IANAP (I Am Not A Psychiatrist), but I am a student about to finish a Bachelor's in Clinical Psychology.

    8. Re:This is what is being done now... by sorak · · Score: 1

      In order to treat these conditions, ECT is the tool of choice these days. It has its own detractors (me inclusive) for I do not see how inducing a seizure helps an individual.

      from your wikipedia link (emphasis mine):

      Today, ECT is most often used as a treatment for severe major depression which has not responded to other treatment,[1] and is also used in the treatment of mania (often in bipolar disorder), catatonia and schizophrenia.

      Also:

      today, an estimated 1 million people worldwide receive ECT every year

      To put that in context, Zoloft has been prescribed 29 million times in 2007. I would not call ECT a "tool of choice", so much as a "last resort".

    9. Re:This is what is being done now... by Anonymous Coward · · Score: 0

      Actually, ECT is not the treatment of choice for Bipolar and Schizophrenia. ECT is the treatment of choice for Major Depressive Disorder (MDD) that has not responded to medication and therapy. Although historically ECT was used for Bipolar and Schizophrenia treatment (and is still in limited use) it has been demonstrated to greatly improve symptoms of MDD.

      As for memory loss with ECT there is evidence that short term (lasting less than 24 hours) memory loss occurs but this memory loss generally associated with the pre/intra and post procedure period.

      "I do not see how inducing a seizure helps an individual"

      There are soooo many things I don't understand, like how string theory helps physicists model matter/energy. With medicine 90% of what the body does is not understood, we are mostly still treating people by changing input and measuring output with very little understood regarding what is going on in vivo.

    10. Re:This is what is being done now... by jcgf · · Score: 1

      I had 8 rounds of ECT a few years back (the big scary bilateral kind too). It helped more and had fewer side effects than any medication that I had tried. I experienced no memory loss and was only mildly disoriented upon waking up from the anesthesia (no more than other times I had surgery). I would go again tomorrow.

    11. Re:This is what is being done now... by Anonymous Coward · · Score: 0

      The only thing moronic and stupid here is your comment. Have you even read a book about ECT and not just gone by what you see on the movies?

    12. Re:This is what is being done now... by jobsagoodun · · Score: 1

      > Psychiatry is evil.

      Would you like to talk about it?

    13. Re:This is what is being done now... by Anonymous Coward · · Score: 0

      In order to treat these conditions, ECT is the tool of choice these days.
      [ ... ]
      Worst of all you could lose all your memory.

      I for one would rather welcome that side effect
      where do I sign up?

    14. Re:This is what is being done now... by Anonymous Coward · · Score: 0

      In order to treat these conditions, ECT is the tool of choice these days. It has its own detractors (me inclusive) for I do not see how inducing a seizure helps an individual.

      Worst of all you could lose all your memory. There was a story of a lady who did not remember anything about her clothes and wondered who had put "foreign" clothes in her closet. In another case, a former doctor could not remember who the hell he was after the procedure. Scary indeed.

      In other words ECT caused this woman symptoms which mimic schizophrenia.

    15. Re:This is what is being done now... by Anonymous Coward · · Score: 0

      If you'd like to hear what a proponent of ECT has to say about the subject, listen to Sherwin Nuland (surgeon and lecturer at the Yale University School of Medicine) tell his own story about how it saved his life.

      http://www.ted.com/talks/sherwin_nuland_on_electroshock_therapy.html

      I challenge you to not be moved to tears by his story.

  24. In perspective by tgibbs · · Score: 4, Informative

    Just to put this in perspective, this is not a gene, but just a region of a chromosome. And the association with any particular locus is weak, so it doesn't look like it is strong enough for diagnosis or prenatal testing. Even when the gene is identified, going from a gene to a treatment tends to be very difficult. We've know of genes for Huntington's Disease and Alzheimer's Disease for years, and while this has inspired a lot of promising research, so far this knowledge has not yet resulting any major improvements with respect to treatment or prevention.

    Moreover, finding that the same genes are involved does not necessarily mean that the diseases are the same, because genes can be "broken" in multiple ways.

    The idea that there is a relationship between schizophrenia and bipolar disorder is not actually new, as there are some people who exhibit characteristics of both disorders, and some people diagnosed with one respond to drugs that are commonly used to treat the other. So this basically adds a bit more evidence to a long-standing suspicion.

    1. Re:In perspective by tgibbs · · Score: 1

      There is still a huge amount of diversity in neurotransmitter receptors due to subunit heterogeneity and splice variants, much of it still untapped in terms of highly selective small-molecule agonists and antagonists. In many cases, specific variants are confined to very small subregions of the brain or specific cell types, and there are also newer strategies such as targeting individual subunits with inhibitory RNAs, so I'm not as pessimistic as you. Nevertheless, there is no reason to imagine that every condition will be treatable by increasing or decreasing the activity of a specific neurotransmitter receptor population.

      Targeting regulatory proteins with small molecule therapeutics is pretty much in its infancy, so it is hard to know how well that will work. Of course, there is also the gene therapeutic approach, which might work well against a regulatory flaw, but delivery and targeting remains a thorny problem.

      We are at a frustrating stage of understanding, in which we are beginning to get an idea of what is going wrong, but our ability to actually fix things is still very limited.

    2. Re:In perspective by tgibbs · · Score: 1

      Nevertheless, pharmacology has been remarkably effective, even if not curative, in treating psychiatric diseases. Despite their side-effects and their limited efficacy against "negative" symptoms, the neuroleptics are miracle drugs with respect to schizophrenia. And the antidepressents are also remarkably effective for some psychiatric conditions. Similarly, benzodiazepines are remarkably effective for anxiety.

      I think that knockouts are a bit misleading here, in that they are so drastic, and also (at least for the older non-inducible knockout technology) are present at a time when the brain is relatively plastic and able to more able to compensate. I agree that behaviors are ultimately dictated by network properties, but such properties can be very sensitive to the behavior of receptors.

    3. Re:In perspective by tgibbs · · Score: 1

      I am too. This has proved to be a very powerful technique in animal models. But establishing safety in the human could be a long process. And in many of these illnesses, it is still unclear what kind of genetic modification would be therapeutic. This will be a hard thing to determine, because the available animal models are of questionable relevance to human psychiatric illness.

    4. Re:In perspective by tgibbs · · Score: 1

      The fact that a drug may be over-prescribed does not mean that it is without efficacy in appropriate conditions. The effectiveness of antidepressants in obsessive-compulsive disorder is clear and often dramatic. Similarly, there is strong evidence for efficacy of a variety of medications in some cases of bipolar disorder. While antidepressants may not be more effective than nonpharmacological therapy for depression on the average, that does not mean that everybody who responds to one will respond equally well to the other. Fears that people treated with stimulants for ADD will find themselves "hopelessly addicted to drugs" have failed to materialize (unless you consider continued treatment with ADD drugs to constitute being hopelessly addicted, in which case diabetics are hopelessly addicted to insulin). Moreover, untreated ADD is by itself a risk factor for drug abuse. I do think that there are valid concerns about the long-term safety and efficacy of stimulants for ADD, as the use of these drugs is based upon relatively brief clinical trials.

    5. Re:In perspective by Will.Woodhull · · Score: 1

      To put this in perspective, there is some doubt that these "hot spots" are indicative of any genetic differences at all. The article is describing epigenetic phenomena (the still mysterious thing that turns genes on and off, either according to some bootstrap sequence or through sensing environmental changes in some unknown way.) It might be that the schizophrenia and bipolar disorder are products of perfectly normal genes that were activated in an unusual sequence.

      It turns out that mapping the human genome is not going to be enough. When we have that done, we will find that we've only reverse-engineered the subroutine libraries and maybe the API; we still don't have a clue where the high level programming that uses this stuff is located.

      Think about the incredibly detailed and precise processes involved in mitosis. This is definitely not happening under the direct control of genes, since it is the genetic structures themselves that are being acted on. So what are the mechanisms that guide this process, and where is the code for this process, and how can we learn to read that code? I'm guessing that these are central questions that the emerging study of epigenetics is looking at.

      --
      Will
    6. Re:In perspective by ajlisows · · Score: 1

      What seems like a thousand years ago, IWABCFOG (I was a Biochemist Focused on Genetics) so I may have some idea what I'm talking about here but it may very well be that some of my speculation is wildly inaccurate/outdated.

      I'm guessing that many of the well known genetic disorders (I'm pretty sure Huntington's falls in this category...don't know about Alzheimer's) very much is a "One Gene/One Polypeptide" type model. A single dominant allele causes the disorder to manifst itself.

      Depression.....just thinking about the general mechanism of Serotonin uptake yields several possible points of failure. Is there a gene that simply cannot produce enough solid serotonin? Is there a gene that produced defective serotonin binding sites? Is there a gene that requires levels of serotonin concentration much higher or lower than the norm to begin reuptake and/or production processes?

      I have a longstanding theory that I admittedly have not done enough research into trying to find it I am way off base or not...but I firmly believe that all too often the physicatric community is so focused on Serotonin being what causes feelings of depresssion when quite often it could very well be the delicate Dopamine/GABA balancing act. Now, I know a lot of people on SSRI's that fail to try to help themselves and rely completely on the medication while lying to their doctor about raging alcohol/drug problems and the like but I digress. With the Dopamine/GABA idea you throw additional genes into the equation for feelings of depression, compounding the problem of definitively nailing down a specific sequence that causes depression.

      My statements in all are just me using my own thoughts of why we can't pin this down to a specific gene. There are probably too many factors to simplify this to a simple "You have the gene for depression" diagnosis.

      I of course, welcome comments about my ideas but please remember two things - 1. I am not presenting any of this as fact. Just some ideas I have kicked around in my head. 2. I may have once been very strong in terms of Biochemistry and Genetics but I am years removed from it and may have ideas that cannot possibly be consistent with reality. I readily admit that. Please refrain from telling me that I am an idiot, but correct me if I have some scientifically obvious flaws.

    7. Re:In perspective by tgibbs · · Score: 1

      To put this in perspective, there is some doubt that these "hot spots" are indicative of any genetic differences at all. The article is describing epigenetic phenomena (the still mysterious thing that turns genes on and off, either according to some bootstrap sequence or through sensing environmental changes in some unknown way.)

      No, they aren't looking at epigenetic markers like DNA methylation, but standard single nucleotide polymorphisms--variations in DNA sequence. That does not exclude epigenetic mechanisms from playing a role in the disease process, but at this point that is sheer speculation.

      This is definitely not happening under the direct control of genes, since it is the genetic structures themselves that are being acted on.

      This does not really make sense. There is no prohibition of self-modifying code when it comes to molecular genetics. There is nothing at all to prevent genes from altering other genes. An example of DNA-modifying genes that has been widely used to create inducible and/or targeted genetic knockouts is Cre-lox recombination

    8. Re:In perspective by tgibbs · · Score: 2, Interesting

      I have a longstanding theory that I admittedly have not done enough research into trying to find it I am way off base or not...but I firmly believe that all too often the physicatric community is so focused on Serotonin being what causes feelings of depresssion when quite often it could very well be the delicate Dopamine/GABA balancing act.

      A long-standing puzzle is that SSRIs enhance serotonergic transmission pretty much immediately, yet it takes weeks for the effects on mood to emerge. Contrast that with stimulant drugs that enhance dopamine release or inhibit uptake, which enhance mood pretty much immediately (ask anybody who has tried cocaine). This has led to a widespread suspicion that it is not enhanced serotonin transmission per se that relieves depression, but rather some downstream regulatory change that occurs in response

  25. That's awsome! by Anonymous Coward · · Score: 0

    No it's not!

  26. I hope this brings things closer to a treatment. by Anonymous Coward · · Score: 5, Interesting

    I hope this brings things closer to a more reliable form of treatment. I grew up with three (yes, 3) women with schizophrenia, and the drugs only muted the symptoms. I (amazingly) don't have the disease myself. My mom and grandma, who I lived with the first ten years of my life, had noticeable symptoms...I'd get told to do things that didn't make sense to me. I'm a rather geeky and analytical girl, and it is very frustrating when the adults in your life tell you things that *make no sense*, and there's nobody around *without* the disease to talk to. They tried to "protect" me from the "ghosts" on one hand, so I'm sure they cared for me in their own way, but on the other hand my mom would attack my grandma because my grandma (who was a heavy smoker and had issues with her lungs) was "talking under her breath". (She wasn't.) Pretty terrifying to see when you're five years old. I wasn't allowed to go to friends' birthday parties if they were in a certain town that, some hundred years ago, had been the former county seat, because apparantly folks from that town were still pissed off at our town and would try to hurt me (this is the paranoia part of paranoid schizophrenia showing). I wasn't allowed to wear the color red, eat strawberries, or get ice cream from the ice cream man truck. My mom would randomly become enraged at my friends dads simply since they were male, so I'd be cut off from friends randomly. My aunt had less noticeable symptoms, but the disease made her a target for an abusive husband, and of course I was exposed to that when I went to live with them as an 8th grader (my mom went back into the mental hospital, and my grandma had died when I was 10). I finally ran away at 16 and went into the state ward system, which was much, much better since I could make decisions for myself, instead of having to obey people who made no sense.

    Schizophrenia sucks. It sucks for the person having it, since you can't hold down a job, and it sucks for the family that has to put up with it.

  27. Where's kDawson? by Anonymous Coward · · Score: 0

    Doesn't everyone know the difference between depression and bipolar disorder? Mod OP down.

  28. DSM diagnostic criteria: by circletimessquare · · Score: 2, Informative

    poor impulse control, disinhibition, lack of concern for others, overly aggressive emphasis on one's own pleasure

    this is the mental condition known as "internet troll"

    familiarize yourself with the Diagnostic and Statistical Manual of Mental Disorders entry for this particular disorder, and show some sensitivity to those affected

    your anger doesn't help in the care and treatment of the mentally altered. more compassion next time please for these poor suffering souls. thank you

    --
    intellectual property law is philosophically incoherent. it is your moral duty to ignore it or sabotage it
  29. Duh by Areyoukiddingme · · Score: 3, Insightful

    Anybody who has had long association with a manic-depressive already knew this. I'm related to one. The first time, he went completely manic. Didn't sleep for a week, etc. The last time he went around the bend, he DIDN'T go manic-depressive. He went paranoid schizophrenic. I can't believe any competent clinician hadn't already noticed that the same patient can easily exhibit symptoms of both, even at the same time. Given that both are caused by imbalances in brain chemistry, and given that the same patient can be both, how big of a leap is it to notice that they're really just different manifestations of the same problem?

    He's much better now, though he still prefers his own flights of fancy to reality. But at least he's capable of distinguishing the two again. After over a decade of on-again off-again lunacy, he's finally decided to take his meds regularly, and he, his therapist, and his mother have found an effective dosage (of Depacote, for the morbidly curious. The stuff works very well, IF, and I repeat IF the dosage is precisely correct. Too little does nothing. Too much ruins the patient's ability to stay awake, let alone function.) It is perhaps telling that regardless of whether he was manic, depressive, paranoid, or schizophrenic, his therapist wanted him to use Depacote. Practitioners already know that the same drug can treat a patient with any of those symptoms.

    So, at the risk of repeating myself... duh?

    1. Re:Duh by nine-times · · Score: 1

      More interesting to me was the idea that schizophrenia shared a genetic basis with multiple sclerosis. As someone who's seen multiple cases of autoimmune diseases and mental illnesses in the same family, it's intriguing to think that it might all be connected.

    2. Re:Duh by Reziac · · Score: 2, Interesting

      I've been saying for years that they are not separate disorders but rather a continuum, with OCD at one end, bipolar in the middle, and schizo at the other.

      I've also noted a cyclic pattern -- typically a crazed episode, followed by a brief apologetic period, then some unpredictable time of being apparently-normal. If the cycle is not interrupted, or if it is in any way enabled, it trends toward worse with each cycle.

      I also content this: ALL children are schizophrenic, and progress thru bipolar and OCD phases as they mature. NORMAL children eventually leave all of these behaviours behind. We notice people "going wrong" in their teens and twenties not because they are "getting sick" but because they are failing to outgrow these normal childhood behaviours, which don't work so well once you leave the nest.

      --
      ~REZ~ #43301. Who'd fake being me anyway?
    3. Re:Duh by NeutronCowboy · · Score: 1

      Anecdote != Data. You make an interesting point, but without corroborating data points, it's not very useful for the larger population.

      --
      Those who can, do. Those who can't, sue.
    4. Re:Duh by Shadowhawk · · Score: 1

      I'm guessing you never studied the scientific method. One point of data (anecdotal evidence) means nothing, even in a "soft science" like psychology.

      The linked story says that both conditions can linked to "the same chromosomal neighborhoods", which is nowhere near the same thing as equating the two conditions (which the summary incorrectly implies). For my counter-point, my mother had bi-polar disorder. She never had any symptoms of schizophrenia or paranoia (and yes, I understand what those symptoms are), but looking back over my childhood, the manic and depressed periods are easy to recognize.

      --
      My mind works like lightning. One brilliant flash and it is gone.
    5. Re:Duh by Areyoukiddingme · · Score: 1

      I also content this: ALL children are schizophrenic, and progress thru bipolar and OCD phases as they mature. NORMAL children eventually leave all of these behaviours behind.

      I don't believe so. After so many years of exposure to someone with the affliction, it is my belief that there is a qualitative difference between the sane and the insane. It's not merely more of the same. They quite literally "think differently." (And if Apple knew what that really meant, they wouldn't think it such a cute marketing slogan.)

      I've had enough contact with children as an adult, including helping raise one for a while, that I can see many differences. Sane children don't hear voices in their head that they're convinced are someone else. Sane children experience emotional highs and lows that many adults have left behind, but they're neither manic nor chemically depressed. They're just children. Everything is new, everything is a first, so everything feels very powerful to them. But watching them, I can see that it's an emotion, not a chemical oddity. They feel it, quite intensely, but then they move on. They may not always be calm, but they don't depart from reality.

      That really is the sole reliable hallmark of mental illness: departure from reality, in one form or another. The manic thinks he can do anything, that he merely has to wave his hand and great wonders will appear. The depressive thinks that he can do nothing, that simply continuing to draw breath is a terrible burden. The schizophrenic believes that trains of thought in their own brain are not their own thoughts, and identifies them as someone else speaking. The paranoid is perhaps the easiest to understand, believing that everyone is out to get them. As far as I'm concerned, the alleged paranoia isn't actually a symptom with chemical origins. It's a reaction to everyone around them contradicting their world view, 100% of the time. Because their brain is out of balance, they believe reality is other than it is, with a degree of certainty that is difficult to imagine without prolonged contact with the condition. When you believe that you can talk to elves, when you know you can talk to elves, being repeatedly told that you can not talk to elves leads to a reaction. We call that reaction paranoia. It's almost understandable, considering the circumstances.

      Children, when contradicted, accept the correction. They may only accept it provisionally, if they're a child who has had adults lie to them too often, but they'll accept it. Most simply accept it utterly, without question. The insane do not - can not - accept correction. That's a big enough difference that I don't believe there's any overlap.

    6. Re:Duh by TheLink · · Score: 1

      > They are failing to outgrow these normal childhood behaviours, which don't work so well once you leave the nest.

      Leave the nest?

      What's this crazy talk? We're fine here in our mom's basement.

      --
    7. Re:Duh by Areyoukiddingme · · Score: 1

      Yes I know, and you're not the only one to point it out. The anecdote was really the lead-in for the point, which was that clinical practitioners have been using the same drug to treat all of those conditions for years already. Not very many years, since Depakote and other current drugs haven't been around that long, and probably not consistently across many practices, but still. When a professional who see hundreds of crazy people in a month has their various patients try a drug and sees positive results, the obvious conclusion is that the biochemistries of the afflictions are closely related.

    8. Re:Duh by Areyoukiddingme · · Score: 1

      You'd guess wrong, so that was rather snide of you.

      Regardless, see my response to the other post pointing out the same thing more politely.

    9. Re:Duh by Polarism · · Score: 1

      Depacote caused massive weight gain in someone I know who was prescribed it. They're on something else now.. not sure what.

      --
      All your base are belong to Google.
    10. Re:Duh by Areyoukiddingme · · Score: 1

      It caused substantial weight gain in the person I know who uses it. Not massive though. I'm sure that depends on the person, just as much as whether or works at all depends on the person.

    11. Re:Duh by Reziac · · Score: 1

      You just THINK you're still in mom's basement.... ;)

      --
      ~REZ~ #43301. Who'd fake being me anyway?
    12. Re:Duh by Reziac · · Score: 2, Interesting

      I've known a number of schizophrenics who were sufficiently low-key that they would never be diagnosed -- but in some way they don't relate properly. The low-key ones don't necessarily hear voices, but they may have other issues, like "feeling like my skin is crawling" when stressed. Some fake normal so well that you have no idea there is a problem -- til you realise there's a coping mechanism at work, such as rehearsing every action til it's "perfect" to avoid embarrassment... and completely losing it (eg. panic attack) when 'caught' being imperfect.

      Two strong common factors are a black/white mentality (inability to deal with shades of grey) and a need to be the center of attention, while simultaneously never ever being *seen* to do anything 'wrong' or otherwise embarrassing. Being 'caught' at being wrong is the single most reliable trigger for a bad episode, for those that do have episodes (not all seem to).

      I started putting that together with kids when I realised that kids do so many of the same behaviours, but in kids we think it's just -- being kids. And it is NORMAL in kids -- until they outgrow it. You can probably predict which kids will NOT outgrow it by observing which are most intolerant of adults interfering with the way they order their small worlds, those that cannot cope with ordinary embarrassments, etc.

      Ever notice kids ordering all their books or toys just so, and getting terribly upset at someone who disorders them? Disorder something an adult OCD has fixated on and watch the same behaviour erupt. OCD in this form is a need to pigeonhole everything, because grey areas cannot be dealt with.

      Ever notice how almost all teenagers have manic and nadir periods, sometimes with only the most trivial trigger?

      Ever noticed little kids playing with imaginary friends?? How many actually think they hear those 'friends' talking??

      Failure to outgrow all this, lack of the chemical triggers that comprise adult behaviour, is what I'm talking about... and if it isn't outgrown, it gets worse, since it doesn't work in Adult Life, and the automatic defense mechanism is to BE EVEN MORE NUTSO.

      And then yes, there is that disconnect from reality -- in the clinical cases. But I've known enough socially-functional schizos that I now believe the clinical/obvious cases are a minority, and that it is actually about 10x more widespread than that -- but we chalk it up to someone being odd or childish rather than recognising that it is a failure to mature compounded by adult stresses. (The math and programming communities are rife with the behaviours... but note that both professions are fundamentally "pigeonholing the universe" ie. OCD.)

      --
      ~REZ~ #43301. Who'd fake being me anyway?
    13. Re:Duh by Anonymous Coward · · Score: 0

      Because they present very differently and disorders can be comorbid? No! That's right, those guys are stupid and they should have been going by the anecdotal evidence of their patient's relatives! Besides, there is already a diagnosis for people who exhibit both schizophrenia and bi-polar.

    14. Re:Duh by lwsimon · · Score: 2, Informative

      I think you're dead on. I had serious issues coping in college, and these days, I believe I am what you call a "socially-functional" case.

      I have bordered on schizophrenia in the past - I have felt my own thoughts race and become uncontrollable, and turn to topics that didn't seem to follow (as if someone else was in control). In my case, I knew that could not be the case, and held tightly the idea that it was a chemical issue. Over time, and with the help of medication (Lexapro and Abilify, for the curious), I learned to stop those lines of thought before they got out of control.

      I hate being wrong - I've learned to deal with it in a professional capacity largely by disconnecting my internal dialogue and my external presence. I may be raging or crawling under the table inside, but as long as I focus on maintaining a professional composure on the outside, I can simply wait it out.

      When I was very young, I remember getting sheets of stickers and not using them, because I couldn't bear the thought of a full sheet with one missing - so I never used the first one. If I was given a half sheet, there would be stickers all over the house ;)

      I'm willing to talk about it if anyone is interested. I can honestly say that managing this has been the greatest challenge in my life so far. I still live with the financial consequences of my actions when I was not yet in control, so it is a bit of an emotional trigger, but I'm happy to do so if it could help someone else live through the same type of thing.

      --
      Learn about Photography Basics.
    15. Re:Duh by jonaskoelker · · Score: 1

      Given that both are caused by imbalances in brain chemistry, and given that the same patient can be both, how big of a leap is it to notice that they're really just different manifestations of the same problem?

      I figure there's a ton of psychiatric condition which can occur at the same time. At some level, they're all caused by brain chemistry.

      Are you saying that all psychiatric conditions are all the same thing? Because your reasoning in this one particular case, when applied to all other cases, sure makes it sound like it.

    16. Re:Duh by Areyoukiddingme · · Score: 1

      It sounds to me like you're mainly describing two things: autism and stage fright. I call stage fright a social anxiety. It seems very much like a learned behavior, to me. It appears in people who have overly-demanding parents. By that, I mean parents that demand high performance from their children (which isn't bad), but then don't recognize and praise successful high performance (which is bad), and don't forgive performance that falls short (which is really bad). Autism is something different, and I'm not sure how much it overlaps with manic-depression/paranoia/schizophrenia. Autism seems like part of a continuum with OCD, to me, and that continuum has, if anything, the opposite problem. Rather than dwelling in their imagination, they see reality too well. And it's scary as hell. Autistic personalities can descend into OCD in an effort to exert control over the uncontrollable by controlling something that is controllable, to excess.

      As for children that order their toys just so and get upset if you disorder them, I think you've found a budding case of autism. No child I've ever known has ever gotten even mildly upset about an adult disordering toys they're not playing with. Quite the opposite. Most of the ones I've known had to be cajoled into producing any order at all.

      I've never had any contact with a truly OCD personality. The kind that will turn the light switch back on in order to turn it back off again. I've seen finicky and fussy and attentive to detail, but never truly interfering-with-life obsession.

      I haven't had a lot of contact with teenagers since adulthood, so I don't have anything to relate. I only hear about emo kids, without having anything to do with them. I don't think what you're describing falls into either category though. Most teenagers are suffering from hormone rebalancing, rather than disrupted brain chemistry. (An imprecise distinction I know, but perhaps it conveys the idea.)

      I've seen plenty of kids playing with imaginary friends. Ask one of them if the friend is really there. You'll get a funny look, and probably an exasperated, "No, don't be silly," which could easily be translated to, "Thanks for ruining my suspension of disbelief you bastard." I think it's a prerequisite of sapience to have an imagination. Most people are willing to concede that what they imagine is only imaginary. The ones who can't concede that get called insane, except clinicians wince if you use the term, and insist on some more "precise" label. Looks like those labels are getting in the way.

      I agree with you that there are major numbers of undocumented cases out there.

  30. Re:Interesting by Anonymous Coward · · Score: 0

    Score +5, Irony.

  31. Awesome but... by XPeter · · Score: 2, Funny

    Slashdot won't be helped until the secrets of Aspergers Syndrome are "Unlocked"

    --
    "The difference between genius and stupidity is that genius has it's limits" - Albert Einstein
    1. Re:Awesome but... by Anonymous Coward · · Score: 0

      Mmmmm... Assburgers.

  32. Yep. Manic-Depression != Depression by morgan_greywolf · · Score: 1

    Yep. That's why they re-named 'manic-depression' to 'bipolar disorder' in the first place. Bipolar disorder is more closely linked to schizophrenia than it is to depression.

    Also, schizophrenia != multiple personality disorder. A schizophrenic may additionally have multiple personality disorder, but the terms are not synonymous. Schizophrenia is more closely classified as a disorder that causes a "break from reality."

    Full disclaimer: my wife is a psychologist and psychotherapist.

  33. Yeah, Yeah... by Greyfox · · Score: 1

    Problem is science doesn't really go that fast, and we're on a 24 hour news cycle.

    --

    I'm trying to teach myself to set people on fire with my mind... Is it hot in here?

  34. Medications vs. Treatment by StealthEMD · · Score: 0

    I know this is an unrelated disorder but the idea I want to present still holds. My father has Epilepsy (non-genetic) and has been on prescription Phenobarbital, dilatin, and Folic Acid most of my life. Though this helped control the seizures it did not address the primary problem... Damage to the right side of his brain. The bigger problem is the impact of the medication on his ability to operate in the world around him. His reaction time, cognition, and memory are all greatly affected and external stimuli can make a tremendous impact on his life. If not for the medication he would probably qualify as a borderline genius, but he would have 3-4 Gran Mal seizures a day. To try and help him doctors have tried him on multiple medications and are now evaluating him for surgery. This is where I make my point. the medications though helpful do not address the problem: damage to the brain. The solution is to remove the damage. The question is how will this affect the rest of his life. The same is true here: Medications do not solve the underlying cause of Schizophrenia or Bi-Polar Disorder. A lasting treatment needs to be developed to provide this capacity. There are underlying problems (genetic, physical, chemical, all of thee above) that need to be treated in a lasting manner. (I am not just blowing smoke out my ass I too deal with imbalance issues including ADD and hormonal imbalances causing gender dysphoria, it is a chemical problem and I find a way to live my life normally despite the fact but I still wish there was permanent treatment.)

    --
    IT Specialist - Nottawaseppi Huron Band of Potawatomi Indians
  35. Am I really going to be the first. . . by Anonymous Coward · · Score: 0

    . . . to suggest that this is the Secret of NIMH?

    I'm disappointed in you Slashdot. Very Disappointed.

    1. Re:Am I really going to be the first. . . by geminidomino · · Score: 1

      We moved away from Nickel-metal Hydride a long time ago. We use lithium now, you kn...

      Ohhh. I see what you did there...

  36. depression is a rational response to the world by Anonymous Coward · · Score: 0

    - in most cases. And is motivation to improve the human condition.

    Mood-altering medication makes those who want to improve the world too apatheic to cause a fuss.

  37. Schizophrenia by Elwar123 · · Score: 1

    I was kinda caught off guard when I was diagnosed with Schizophrenia. Me too.

  38. Re:I hope this brings things closer to a treatment by mcgrew · · Score: 1

    And it sucks more in the US because you usually can't get treatment because there's no way a person with schotzophrenia (or most other mental illnesses) can hold a job, and without a job you have no insurance, and without insurance you have no medical care.

    My late friend Jim (I knew him since we were teenagers) married a woman with bipolar disorder, and that's hell for the loved ones and especially the kids, too. After the divorce, when it was her turn to get the kids, they'd have to drag their son Todd kicking and screaming (Jim finally got permanent custody of Todd and his sister).

    Todd's in his thirties now, and amazingly he's the sanest person I know.

    There was a bunch of us at another friend's house after Jim died watching the movie "Misery". A while into the movie, Todd exclaimed "Oh shit, that's my MOM!"

    The actress even looked like his mom. I'd much rather have my arthritis than be stricken with a bad mental illness.

  39. Roses are red, by smackenzie · · Score: 1

    Violets are blue.
    I'm schiophrenic,
    And so am I.

    1. Re:Roses are red, by Locke2005 · · Score: 1

      Remember: you're never alone with a schizophrenic.

      (Well, actually you're never alone with someone with multiple personality disorder, but that doesn't roll off the tongue like "schizophrenic" does.

      --
      I've abandoned my search for truth; now I'm just looking for some useful delusions.
    2. Re:Roses are red, by Anonymous Coward · · Score: 0

      How did this get modded 2 when it is easily a -1 submission?

  40. Just a wild guess but... by Anonymous Coward · · Score: 0

    I would believe they first studied the subject for better part of a decade in university, got good enough reputation in their area of expertise that they were awarded large sum of money to research the subject, then spent lots of resources (money, skill and time) to come up with their results...

    Honestly, if there was one or two sentences of explanation to sum all that up in a way that Joe Sixpack would understand it... That would be a lot more dubious.

    To determine how reliable this research is we need to wait for experts to comment on it. I wouldn't trust Internet commenters' analysis of it any more than I would trust a PhD in neurology to code review my work.

  41. Re:Interesting by Anonymous Coward · · Score: 0

    Wow, my eyes have been opened to the Truth!

  42. Achievement Unlocked by djdavetrouble · · Score: 1

    Now that we have unlocked this, it is only a matter of time until someone beats the Final Boss !

    --
    music lover since 1969
    1. Re:Achievement Unlocked by sabernet · · Score: 1

      I dunno. He wields a mighty powerful scythe, that one.

      Looks like a metal fan, though. Maybe run in blaring Vivaldi's Four Seasons?

  43. A return to the pre-Thorazine days by benwaggoner · · Score: 2, Interesting

    Interesting.

    Back before psychopharmaceuticals, schizophrenia and depression were thought to be very similar or even the same thing. It was only once we had Thorazine (first antipsychotic) and then later tricyclics (first antidepressents) that in the clinical settings schizophrenia and depression began to be sorted much more distinctly, essentially based on the kinds of patients that got better with antipsychotics versus those that got better with antidepressants.

    It's pretty common for diagnostic definitions to align with successful treatment methadologies, since "what will help" is the fundamental answer that diagnosis hopes to lead to.

    Sounds like we're now getting back to the perspective of a half-century ago.

    1. Re:A return to the pre-Thorazine days by Calithulu · · Score: 1

      Oh? If this trend continues I look forward to the resurgence of electro-shock therapy.

      Good times.

  44. And here I thought.. by Drathos · · Score: 1

    ..that the Secret of NIMH was super-intelligent, magic using rats..

    --
    End of line..
  45. Re:Need to slow down when reading the article titl by Anonymous Coward · · Score: 0

    How about give them some Medical grade American-Grown skunk Cannabis, and monitor the changes!

  46. Life is so unfair! by Locke2005 · · Score: 1

    You mean, there are people out there with personalities to spare, while us poor slashdotters don't even have a single personality to our name? They really need to spread the wealth around...

    --
    I've abandoned my search for truth; now I'm just looking for some useful delusions.
  47. Worked for Pirsig, he got a best-seller out of it. by Anonymous Coward · · Score: 0

    I guess Hemingway had a minor issue with the treatment, but I think he was able to resolve his situation in the end.

  48. Re:Need to slow down when reading the article titl by networkconsultant · · Score: 1

    Yes and no.

    Bi-polar is episodic (as are most forms Schizophrenia) actually bi-polar is often an off shoot of Schitzo-effective disorder; the only major similarities being the "Rages", "Delusions" and "Hallucinations". Most Psyciatrists use the same Lithium / anti-psychotic / SSRI / NSSRI / MAOI blend to try and treat them but "Bi-polar" is often given to the less severe of the bunch. DSM-IV characteristics have diffrent "Features" where bi-polar is prone to "Impulse"

    MAD (Major Depression) has all the same features of the Lows of Bi-polar but lacks the episodic nature and often features oversleep, neruoepinephrine, dopamine and serotonin insensitivity or underproduction (which could be hereditary in nature or caused by chemical damage to the limbic system i.e; heavy metal poisoning ), the major issues surrounding good diagnosis lie in the fact that to be 100% accurate we have to by-opsy the tissue, in most cases this requires a labodomy.

  49. That's all very well but... by Anonymous Coward · · Score: 0

    What about the slightly grumpy first thing in the morning disorder, or inability to concentrate when the neighbours are shouting at each other syndrome. Perhaps they could concentrate their efforts on the sitting in the basement coding malady.

    Different doesn't mean ill. Psychiatrists suffer from the desire to interpret human characteristics which they aren't keen on as a syndrome. That inclination in itself is probably worthy of further study, and in my opinion should be top of the list. Trouble is we couldn't trust the psychiatrists with it.

  50. As opposed to regular medicine by Anonymous Coward · · Score: 0

    As opposed to regular medicine where you'd only get 9. (Yes I'm bitter.)

  51. Re:I hope this brings things closer to a treatment by SWolf1 · · Score: 1

    And it sucks more in the US because you usually can't get treatment because there's no way a person with schotzophrenia (or most other mental illnesses) can hold a job

    Untrue, there are federal programs for people with mental illness to afford housing and necessary drugs. I know because I have relatives who are schizophrenic.

  52. Not For Everyone by Anonymous Coward · · Score: 0

    I have bipolar disorder. I go through manic phases followed by depressive phases. Sometimes mine are short (i.e. hours) but intense. Other times they last for months. I am obsessed with the problem of P vs NP, and thinking about it too much can lead me into manic phases, where I become convinced that I've solved the problem, and that others (i.e. teachers and friends) are out to steal my ideas. I become paranoid and write my name and the date on everything I write, in case someone claims my notes as their own. I become convinced that I am the reincarnation of Godel, Turing, John Nash, or other mathematicians. I converse with my "former selves" and tell them about my ideas. They respond with fascination and sometimes suggestions of their own. My mind spins and reels, and it feels sometimes like it becomes completely detached from my body.

    It's true that while I'm manic, I can get abnormal amounts of work done. I also speak incredibly quickly, and develop a stutter because my mind moves too fast for my mouth to keep up. I call them 'cache misses' because my brain has to stop and go back to where it was just seconds ago, in order to 'fill in' the missing words. Because I think so quickly while manic, I become frustrated and irritated with anyone and anything that stops me from thinking as quickly as I'd like to. I have trouble sleeping at night, and when I do sleep, I dream of absurd mathematical problems that don't make any sense. Once I was skiing with some friends, and I had a dream wherein each ski route was assigned an integer value. It was up to me to make sure that the sum of the slopes traversed by my group was exactly zero. I had to keep convincing people to do different slopes in order to keep things balanced. When I have those dreams, I have a hard time waking up because I want to solve the problem so badly that I can't get out of bed. Additionally, when I'm manic, I drive more recklessly and take risks that I shouldn't. I'm much more likely to go home from a bar with a girl that I shouldn't. It seems like my sex appeal dramatically increases while I'm manic. This could be because I'm just thinking more highly of myself in general, but it could also be because i'm more aggressive, bold, and confident, all of which are appealing to girls.

    The flip side of the mania is depression. When a manic phase ends, it usually leads to a depressive phase, when I realize i'm not a super genius capable of anything, and that my conversations with past mathematical figures are hallucinations. I think of myself as hopelessly stupid and doomed to live an unhappy life. It's not just being sad. It's a state of total hopelessness and despair. The only thing in the world that is remotely appealing is killing myself, which I dream of constantly. I've attempted suicide three times, each time getting closer to actually finishing the act. The last time I tried, I was standing on the 28th floor of a building in downtown Seattle, trying to work up the courage to jump off the ledge. If it weren't for some people who happened to come up the elevator as I was sitting on the ledge, I probably wouldn't be typing this today. I know that suicide is a terribly selfish thing to do, but until you've experienced the despair and hopelessness associated with bipolar depression, you can't begin to understand how much it makes sense. After my second attempt, I was taken against my will to a mental hospital, where I spent a few days. It was the worst experience of my life. All it impressed upon me was that, if I ever feel like suicide again, I shouldn't tell any medical professionals because they might take me back there. Even when I'm perfectly happy and level(i.e. no longer in a depressive or manic phase) I still occasionally think about killing myself. When I hear a story in the news about a plane crash or a celebrity dying, my first thouhgt is always to be envious of them. Just writing this post is making me want to kill myself.

    As if the hopelessness, despair, and suicidal idealization weren't bad enough, I lose my attentio

  53. Re:Need to slow down when reading the article titl by Muad'Dave · · Score: 1

    ...we have to by-opsy the tissue, in most cases this requires a labodomy.

    I think your spelling meds have worn off - aside from the other obvious typos, those would be "biopsy" and "lobotomy", respectively.

    --
    Tiller's Rule: Never use a word in written form that you've only heard and never read. You will end up looking foolish.
  54. Comment removed by account_deleted · · Score: 1

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  55. Re:Need to slow down when reading the article titl by Lostlander · · Score: 1

    Achievement unlocked! you have watched your 10,000,000 hour of pr0n.

  56. Comment removed by account_deleted · · Score: 1

    Comment removed based on user account deletion

  57. Sure, let's medicate it.. by Seth+Kriticos · · Score: 1

    I always thought this kind of condition would have something to do with people having shitty jobs, financial troubles, dysfunctional families, partners spying on them to see if they are faithful or similar circumstances.

    It's all about genes, what a relief. We just have to takes some more of those funny looking pills, and everything will be alright.

    Now excuse me, I'll go kill myself.. should I bring something on the way back?

    1. Re:Sure, let's medicate it.. by spads · · Score: 1

      Of course this will get modded down, but 5 will get you 10 these "researchers" don't know doodly squat. Huge portions of human behavior (ie. that which is evolutionarily adaptive) are hard-wired, but 99+% of psychopathologies are "nurture" (ie. experiential) as opposed to "nature" (ie. hard-wired).

      There were strivings made for this understanding in the past (eg. Freud/psychoanalysis), and one day they will return again, but for now people will just continue to eat all of the garbage that pharmaceutics industry continue to feed them.

      Note: Chronic insomnia is an interesting example of what appears to be a psychopathology (according to the true, not traditional, definition of that term), but which is actually evolutionarily adaptive. Chronic insomnia is actually the selective retention of sleep neurotransmitters, similar to the form of clinical depression which is effectively treated by SSRIs. (Note: there are some good meds out there.) Interestingly, it is evolutionarily adaptive because (counterintuitively) over time it weakens the ~~individual's~~ resolve, turning him towards the comforts of hearth and home. That is, makes him a more willing breeder. Interestingly, too, this (insomnia) can be effectively "treated" with elavil.

      Again, there are some excellent drugs out there, but sadly they are the exception, not the rule. Fortunately, though, the rule is the amazing elasticity and regenerative powers of the psyche when it is medicated with understanding. Understanding filters the world's garbage.

      --
      Bukowski said it. I believe it. That settles it.
    2. Re:Sure, let's medicate it.. by gestalt_n_pepper · · Score: 1

      Freud/psychoanalysis *failed* big time - a fact noticed way back in the 70s when I was getting my psych degree. Psychoactive chemicals *work* even if they do so imperfectly. Moreover, "99%" of psychopathologies are NOT nurture. Depression, Bipolar disorder and Schizophrenia have a huge genetic component, as do personality disorders like Histrionic or borderline personality disorder, et. al. The adaptive explanation is a straw man. MANY behaviors are adaptive, in a given environment. That doesn't mean that they're desirable in *any* environment. Mental illness, as always, is a social, not an absolute definition. The chemicals you define as "garbage" are simply tools to deal with society as it *is* in a current context. Are some of these harmful? You bet! Just like alcohol, opium, Amanita Muscaria, and St. John's Wort can be harmful, to certain people, in certain amounts, in certain situations.

      --
      Please do not read this sig. Thank you.
  58. Comment removed by account_deleted · · Score: 1

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  59. Comment removed by account_deleted · · Score: 2, Informative

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  60. Re:I hope this brings things closer to a treatment by Anonymous Coward · · Score: 0

    There was a bunch of us at another friend's house after Jim died watching the movie "Misery".

    Damn. That must be one lousy movie!

  61. Re:Need to slow down when reading the article titl by MaskedSlacker · · Score: 1

    That's 1141 years of continuous pr0n. I think (I hope?) it's safe to say that there isn't that much pr0n in existence....yet.

  62. Manic Depression vs Clinical Depression by irotsoma · · Score: 1

    Just wanted to point out that this article is talking about Manic Depression (aka bipolar disorder) NOT clinical depression. Manic is when you have lots of ups and downs. Clinical is when you are only down. In fact the article that you linked to on NIMH doesn't even use the word depression at all probably to avoid this confusion, it says bipolar disorder. You may want to change the wording in this post.

  63. Re:Need to slow down when reading the article titl by Anonymous Coward · · Score: 0

    How's this for spelling: Fuck You.

    Glad you're admitting my holiness.

  64. Comment removed by account_deleted · · Score: 1

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  65. Manic depression != Depression by crmarvin42 · · Score: 1

    "According to the US National Institute for Mental Health in Bethesda, Maryland, scientists have discovered a remarkable similarity between the genetic faults behind both schizophrenia and manic depression in a breakthrough that is expected to open the way to new treatments for two of the most common mental illnesses, affecting millions of people. Previously schizophrenia and depression were assumed to be two separate conditions, but the new research shows for the first time that both have a common genetic basis that leads people to develop one or the other of the two illnesses."

    I havn't read the article, so I don't know which one is actually being connected to schizophrenia but I do know that Manic Depression is very different disease from Depression symptomatically.

    Manic depressives have mood swings that include a manic phase in which much of their risk assessment skills go away and they engage in reckless and frequently life threatening behavior. These are usually followed by depressive phases that may be similar to that experienced by a Depressive person. Antidepressants have been shown to be counter productive in Manic Depressives because of the unfortunate interaction between the medication and the Manic phase.

    Besides, I was under the impression that there has always been a belief that manic depression and schizophrenia were related somehow. At least that's what my mother (who works as a psychiatric nurse) told me.

    --
    Bureaucracy expands to meet the needs of the expanding bureaucracy.-Oscar Wilde
  66. Re:Need to slow down when reading the article titl by interkin3tic · · Score: 1

    There is a big difference between Depression and Bipolar/Manic-Depressive disorders.

    In the symptoms, but they can have common genetic factors. DISC1 for example has been implicated in a few cases of schizophrenia and bipolar disorders even though there is a big difference between those two.

    An infected gunshot wound on your arm and being shot in the gut are different injuries with different treatments, but they both were caused by someone shooting you.

  67. Comment removed by account_deleted · · Score: 1

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  68. a /. record for misleading story title by cinnamon+colbert · · Score: 1

    gosh, even the PR from the NIH can't make it sound that exciting: in ONE of the studies, the 2 diseases map IN PART to the same regions of the chromosome...

  69. Not surprising, but very important research by Anonymous Coward · · Score: 0

    As people have commented, yes, clinicians, sufferers etc. have long suspected there is a link between these illnesses, based on similarities between certain symptoms, mutual effectiveness of drug regimens like the atypical anti-psychotics, and so forth. However of course in science it is nice to have empirical evidence for such suspicions.

    To me, while many of the comments were if anything a little above /. standards, it was a bit disappointing to see (Clinical) Depression and Manic Depression / Bipolar Disorder conflated so readily in the OP. While we have good reason to suspect (again, more evidence would be nice) that the two exist on something like a continuous spectrum of mood disorders, nonetheless the distinction between them is a real one. I would know - I was diagnosed with Bipolar Disorder (Type I for those who care to observe the distinction) following a Manic episode which landed me in a psychiatric ward. I certainly found a great deal to empathise there with my fellow patients including several who were presumably Schizophrenic. I must say though I am glad I am not affected by the latter; it is undoubtedly tougher to live with, since at least with Bipolar you get a mixture of less rational periods (both up and down) with periods of relatively "normal" thinking and mood. So you get a mixed perspective of both more and less sane viewpoints, which I find valuable at least.

    OTOH my dad has suffered from Clinical Depression throughout much of his life, which has included a period of severe substance abuse, so of course I have familiarity with that condition as well. Trust me, its really not the same thing. He has never felt inspired to become the prophet of a new religion, for example, or engaged in cryptic metaphorical conversations with other psych patients, or experienced paranoia strong enough to require sleeping at a family's friend's place to avoid a potential murderer. I have (and for what its worth have never touched any non-prescribed mind altering substance stronger than one or two puffs of pot in my entire life.) You only have to experience full blown Mania - or witness it first hand, so my friends and family tell me - to appreciate that Manic Depression is not really the same as plain old Depression.

    So while labels aren't something that concern me a great deal, and I would be just as comfortable to be described with the term Manic Depression, I begin to appreciate why the medical community changed the name of this particular condition to try and reduce the possible confusion surrounding the terminology.

  70. Schizophrenia != Multiple personalities by jonaskoelker · · Score: 1

    Note that schizophrenia and dissociative personality disorder (formerly multiple personality disorder) are two distinct conditions.

    Schizophrenia is characterized by auditory and/or visual hallucinations, plus delusions. See also http://en.wikipedia.org/wiki/Schizophrenia.

    1. Re:Schizophrenia != Multiple personalities by Anonymous Coward · · Score: 0

      so will this be of use to people with the delusion that there is a wage gap whereby women only receive 70 cents to a man's dollar?

  71. But how to rescue it? by jonaskoelker · · Score: 1

    This could be very bad for the tin foil hat industry.

    Clearly this calls for a big government bailout!

  72. Sure, they can fix depression... by VomitInc · · Score: 1

    ... but do you think they'd bother to have a look at the diodes down my left side? Of course not!

  73. Comment removed by account_deleted · · Score: 1

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  74. Re:I hope this brings things closer to a treatment by Anonymous Coward · · Score: 0

    Wow.. I totally understand what you're saying, considering I grew up with both parents having Schizophrenia. It really does suck for both the children being subjected to it and the people who have schizophrenia. My frustration and my mom being put back into a mental institution caused me to move out when I was 16 as well. Its sad because they really do care for us, but have so much trouble controlling their minds. I had to deal with a rough childhood, but its made me thankful of my life because of what my parents have to go through everyday. I hope that your life is going better now, and I'm glad like me you were able to escape the gene continuation.

  75. For Madmen Only by Anonymous Coward · · Score: 0

    I have kind of similar experiences. As a young student, I was always in my head. I didn't care for girls, music, fashion, parties, booze and all the "good stuff". I was the odd one out, and they made pretty sure I knew it. I had one friend who I practically saw every single day, for years, until he commited suicide about five years ago.

    Because I desperately wanted to fit in, I stopped really talking to people, as whenever I'd speak honestly I'd get funny looks. I tried to dumb down and blend in.

    At the same time I started working on the class clown title. I guess you know enough popular psychology to draw your own conclusions as to why.

    Because teachers felt I needed a more stable environment to develop my "giftedness", social services almost took me away from my family.

    I started self-medicating, first with alcohol, then cannabis, and finally, when my access to that was cut off, heroin. Funny how drug control laws can make it easier to get a gram of heroin than a gram of cannabis. Let me summarize I've had an interesting last ten years.

    I'm 31 now, soon to be 32, and off hard drugs but I still drink and smoke blunts from time to time.

    I'm unemployed and pretty much socially isolated, if mostly by choice, all in spite of having a "brain the size of a planet". I spend my time thinking about the big picture, reading up, "grokking" relationships and systems, and I still can't talk to people about my semi-enlightened thoughts, because it's "too intense" or "too depressing" for most people.

    Welcome to the third millenium Christian time, when all that being "gifted" gets you is a ruined life.

    The funny thing is that they'd probably call be depressed, while I'm certain I'm fine. I just see the world for what it is.

    1. Re:For Madmen Only by alexo · · Score: 1

      I had one friend who I practically saw every single day, for years, until he commited suicide about five years ago.

      Um...
      I'm not sure it came out the way you intended it to.

  76. Re:I hope this brings things closer to a treatment by Anonymous Coward · · Score: 0

    Sending a virtual hug your way....

  77. Re:I hope this brings things closer to a treatment by dagda76 · · Score: 1

    And it sucks more in the US because you usually can't get treatment because there's no way a person with schotzophrenia (or most other mental illnesses) can hold a job

    Untrue, there are federal programs for people with mental illness to afford housing and necessary drugs. I know because I have relatives who are schizophrenic.

    Many people with schizophrenia aren't able to successfully jump through the multitude of hoops required to deal with any government program.

  78. First AIDS, Now mental Illness... by jameskojiro · · Score: 1

    Soon you will say Cancer has been cured as well, are we going to hit the singularity like a brick wall?

    --
    Tsukasa: All I really want, is to be left alone...
  79. This has got to be propaganda. by terbo · · Score: 1

    Until something changes, I have to treat this as more propaganda.
    When the same press release admits to many other factors in these
    "diseases" and even its own "medicine" system to be at fault, this just
    sounds like more dribble.

    --
    If you're interested in facts I'll tell you what they are and I'll give you sources - Chomsky on The Big Idea
  80. Bull Puckey by zaivala · · Score: 1
    They have yet to prove a chemical imbalance (or even test for it, except in cadavers), and their attempts to test for a genetic cause seem to consist of one group claiming they found something and another group saying, no, that's not provable, or we didn't find that in our subjects. Why don't we just wake up and say that depression, bipolar, schizophrenia, or whatever label-of-the-month has an EMOTIONAL cause and DEAL WITH THE EMOTIONS THAT CAUSED IT. Every blog out there by a survivor of bad psychiatry states this clearly, and almost 10% of the psychiatrists themselves (in the US -- much larger percentages in Europe) have admitted it.

    Dr. Peter Breggin was published just Tuesday in The Huffington Post http://www.huffingtonpost.com/dr-peter-breggin/medication-madness-how-ps_b_223922.html about the BS involved, and stated that when we are in crisis we need our entire abilities to help us get out -- and that psychiatric drugs ALL remove some part of these abilities.

    Do you want to lose your ability to program or hack because some doctor slaps a diagnosis on you and poisons you with psych drugs until you can't even sit up without drooling? Psychiatry is flat-out pessimistic about any "treatment" they have. All diagnoses are "permanent" and "not curable but treatable", and are caused by a "chemical imbalance in your brain". Then why is it that, with no treatment or declined treatment, over half of all "psychiatric patients" recover completely? Get your act together, psychiatry is BAD SCIENCE or NONE.

  81. I was going to RTFA... by Samah · · Score: 2

    I was going to RTFA but my other personality was too depressed.
    NO I WASN'T!
    Yes he was!
    Shut up you two!
    I think you ought to know I'm feeling very depressed...

    --
    Homonyms are fun!
    You're driving your car, but they're riding their bikes there.
  82. story by Gar-fonz · · Score: 2, Interesting

    I am not a student of the Psychiatric discipline. I have learned through my experiences and reflection to manage my thoughts. I was 'diagnosed' with Schizophrenia a few years ago, and took Risperdal for about 2 1/2 years. During the first six months of the 2.5 years, my dosage increased from 0.5 mg to 4 mg. I stopped taking the medicine in October, 2008. The voices returned in about 2-4 weeks. "People with schizophrenia have reduced brain receptors for the dopamine messenger. " from: http://www.independent.co.uk/news/science/unlocked-the-secrets-of-schizophrenia-1727987.html I believe that this is inconsistent with 'facts' that my ex-psychiatrist told me ( although I could be remembering wrong, which just creates the need to investigate the facts that scientists have found by means that, well, I do not possess knowledge of). I thought that Schizophrenia is a result of an overproduction of dopamine, oh, oops, now I get it.\ I think the Risperdal is supposed to suppress the production of dopamine, perhaps the surplus of the messenger creates the hallucination. For me, the hallucinations are (attempting mental reconstruction to change the present state of is to past tense) my interpretation of the source of the voices. I used to think that other people's thoughts were being transmitted into my mind. I honestly believed it was, just because the 'hear-think' (that's my term for the voices) always had personal information about me, and well, I was around people that would have facts to produce the analysis (negative at first...). I used to conclude that the voices were not invoked by my volition. Well, yeah, OK, whatever, let's shoot that one down. How do I know that it isn't just my brain using the presence of the those around me, to help me realize new perceptions on past situations in order to affect my future choices in a way that I perceive will increase my self-image. Typing of self-image, maybe my mind/soul/etc is just creating a way to reflect so that my volition doesn't have to be the naysayer. With my mind operating this way, I can now respond to the critique of the voices, as if I am holding a conversation in my mind. Oh yeah, one interesting thing about hear-think is that is seems to be occurring outside of my body, in a variety of locations in space. I hear male and female voices, with classic gender roles intact, with a varying degree of acuity in expression, tone, knowledge, and insight. I think the longest phrase lasted between 1-2 minutes. Another unusual occurrence is how in sync the voices can be with my surroundings, meaning that the voices will match body language of other people, and the hear-think seems to be originating from their bodies. I think that I am just imagining an interpretation. the real struggle for me was learning not to trust the voices by using scientific method, by testing their validity against family and friends. have heart.

  83. Re:Need to slow down when reading the article titl by Anonymous Coward · · Score: 0

    MORE... is being MADE... every DAY.

  84. Another Pharmaceutical Trick? by pendrag · · Score: 1

    Guys, have you wonder if this is just another threat orchestrated by the big pharmaceuticals to keep the population sedated for not so clear clinical reasons? Now, it turns out that the normal states of joy and sadness in any individual are prescribed with bipolarity by psychiatras and psychology experts. Think about it.

  85. Anonymous Coward by Anonymous Coward · · Score: 0

    Does anybody know the name of the Abstract in wich this info. is?

  86. Hold off on the party by sjames · · Score: 1

    Claiming that the secrets are unlocked is WAY premature. What we have is a tantalizing hint and some new information.

    They have found through statistical analysis several hundred genes that seem to contribute to the odds of suffering schizophrenia or depression.

    As for what those genes do? "some of them somehow influence the immune system. That's it, full stop. They do some unknown thing that causes some unknown thing that makes it more likely that you'll suffer from a condition caused by an unknown mechanism.

    So yeah, all we have to do is <handwaving level=extremelyvigorous>some immune system thingy</handwaving> and everybody's cured.

    Not saying the research isn't important and useful, just that it doesn't constitute a cure or treatment nor does it even suggest a mechanism for the disease.

  87. I'm knowledgable in the ways of science by Anonymous Coward · · Score: 0

    Of course there is an objective test. What do we know about schizophrenics? Well, we know they burn, as do logs. What else do logs do? That's right, they float. And what else floats on water? Yes, ducks. If the schizophrenic weighs more than a duck, fill them with mind altering drugs which will obviously help them think clearly.

    Seriously, there is no empirical evidence yet it claims to be a science? Snake oil at its finest. Schizophrenia = resisting brainwashing by the system. Pink Floyd and all that.

  88. Yeah, this is all real funny ... how about this: by Anonymous Coward · · Score: 0

    http://moinuddin-sarker.org/

    Karin Kaufman, who is rich but is in psychosis because she stopped taking her powerful anti-psychotic meds in 2002, created a research laboratory at great expense in 2003 to save the world from âoepoorly-ordered poisonous heavy metalsâ. The name of that laboratory:

    Natural State Research