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Neurons Created Directly From Skin Cells

alx5000 writes "The Times is running a story about a neurologic breakthrough that could revolutionise treatments for conditions such as Parkinson's disease and Alzheimer's: Neurons have been created directly from skin cells for the first time. Quoting neurobiologist Professor Jack Price: 'This suggests that there are no great rules — you can reprogramme anything into anything else.' The article also points out that this method could work around the ethical issues surrounding embryonic stem-cell research."

231 comments

  1. sweet by Dayofswords · · Score: 0

    but where will south park turn to for jokes? skin cells are not that funny

    --
    Someday we'll hit the human carrying capacity. And the band will just play on.
    1. Re:sweet by gestalt_n_pepper · · Score: 4, Funny

      It all depends on where they get the skin, and from whom.

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      Please do not read this sig. Thank you.
    2. Re:sweet by pilgrim23 · · Score: 0

      Q: why is phoning your mom like sluffing skin ? A: one is making a phone call, the other is making a clone fall....

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      - Minutus cantorum, minutus balorum, minutus carborata descendum pantorum.
    3. Re:sweet by Hognoxious · · Score: 1

      Not to mention how.

      --
      Confucius say, "Find worm in apple - bad. Find half a worm - worse."
    4. Re:sweet by Hatta · · Score: 2, Insightful

      I don't get it. That joke in no way implied that my mom was fat or a whore. How is that funny?

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    5. Re:sweet by Anonymous Coward · · Score: 0

      sluffing -> sloughing

    6. Re:sweet by K.+S.+Kyosuke · · Score: 1

      From skinny nerds, obviously. Doubles the effect!

      --
      Ezekiel 23:20
    7. Re:sweet by Chris+Burke · · Score: 1

      One's making a phone call, the other is making a clone fall... to a whore!

      Wait, lemme try that again.

      --

      The enemies of Democracy are
    8. Re:sweet by FatdogHaiku · · Score: 2, Informative

      So, if you need neurons replaced in your forbrain they will make then from foreskin?

      insert dickhead joke here

      --
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  2. So, wait... by Anonymous Coward · · Score: 0

    ...The next time I tell one of my users to get off their ass because they're depriving their brain of oxygen, it'll be more than a snarky, shit-headed remark?

  3. Perfect explanation by srussia · · Score: 2, Funny

    So that's why they cut of the foreskin.

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    Set your phasers on "funky"!
    1. Re:Perfect explanation by Anonymous Coward · · Score: 0

      So that's why they cut of the foreskin.

      You're only at the tip of the iceberg in relation to this mystery. Go down deeper!

    2. Re:Perfect explanation by Ukab+the+Great · · Score: 1, Funny

      If your brain was repaired with foreskin neurons, someone could call you smeghead and it wouldn't be an insult.

    3. Re:Perfect explanation by girlintraining · · Score: 3, Informative

      So that's why they cut of the foreskin.

      Actually, yes. The foreskin contains about 90% of the nerve endings on the penis. It's rather barbaric that this country is one of the few in the western world that routinely mutilates male anatomy -- many parents often not even knowing why it's done, only that everybody else does it. more info. For the very few men that have been circumsized as an adult and had an opportunity to experience sex both ways -- they say that sex is very disappointing after. Some become suicidally depressed.

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    4. Re:Perfect explanation by Anonymous Coward · · Score: 0

      So that's why they cut of the foreskin.

      No one wants to be a dickhead.

    5. Re:Perfect explanation by jgtg32a · · Score: 1

      Right, because the brain of a baby isn't going to repurpose those neurons in the brain for the surrounding area, you know the rest of the penis.
      I don't remember exactly what it's called but it is closely related to phantom limb, it may not work out so well for an adult but in a baby's brain it'll be fine.

    6. Re:Perfect explanation by negRo_slim · · Score: 1, Funny

      It's not only neurons and nerve endings but the very real fact it's going to look like a loose old sock uncut.

      --
      On the Oregon Cost born and raised, On the beach is where I spent most of my days
    7. Re:Perfect explanation by Kozz · · Score: 3, Insightful

      Actually, yes. The foreskin contains about 90% of the nerve endings on the penis. It's rather barbaric that this country is one of the few in the western world that routinely mutilates male anatomy -- many parents often not even knowing why it's done, only that everybody else does it. more info.

      Read, please. "Barbaric" and "mutilate" are highly emotionally charged words. I'm a father. I've got two sons. I was circ'ed as an infant, as were both of my boys. I asked all the questions -- is it necessary, is it recommended, why or why not, etc. I decided to go ahead, and I know exactly why I made that choice based on scientific data. If someone else is informed of the scientific data and chooses against circumcision, I fully respect that and have no problem with it. I can tell you that the child displayed little evidence of pain, as I was right there with the doc as it was done, and it heals quite quickly. And no, not "everybody else" does it. The number of uncircumsized males in the US is increasing, actually. You might find the numbers surprising if you have time to look it up.

      For the very few men that have been circumsized as an adult and had an opportunity to experience sex both ways -- they say that sex is very disappointing after. Some become suicidally depressed.

      Which, by your admission, is a tremendously small number of the male population. And if you become suicidally depressed because you're having disappointing intercourse, I'm guessing it's not just about the intercourse.

      --
      I only post comments when someone on the internet is wrong.
    8. Re:Perfect explanation by Archangel+Michael · · Score: 1

      I wonder if that is the problem Tiger Woods has. He obviously was thinking with the wrong head.

      --
      Agent K: A *person* is smart. People are dumb, stupid, panicky animals, and you know it.
    9. Re:Perfect explanation by K.+S.+Kyosuke · · Score: 1

      Well, this procedure will make you a skinhead regardless of the origin of the skin cells, won't it?

      --
      Ezekiel 23:20
    10. Re:Perfect explanation by DigiShaman · · Score: 0

      It's been said that circumcision reduces the chances of STDs and cancer for both partners. Second, many women prefer cut men because it's "cleaner" when performing fellatio. Third, I've read stories that circumcised men also "last longer" in bed because the feeling isn't as intense for them compared to an uncircumcised man.

      So girl, if it's better for you and him, why do you care if he's cut or not?

      --
      Life is not for the lazy.
    11. Re:Perfect explanation by MartinSchou · · Score: 4, Insightful

      Why not let your sons decide if they want to be circumcised? Why force what is essentially either plastic surgery or an amputation onto an infant?

      I am a firm believer in personal freedom. If adults want to be circumcised, I see no reasons they shouldn't be allowed to be, whether they are male or female. But doing it to an infant ... that's a line I'm very much against.

    12. Re:Perfect explanation by DrGamez · · Score: 2, Insightful

      And your feet look weird, lets shave off that ugly pinky toe. And why do we have earlobes if we aren't going to wear anything there? Snip those as well. You're saying parts of the human body look weird, so we should take them off before the person can say otherwise - got it.

    13. Re:Perfect explanation by Tenek · · Score: 4, Interesting

      I'm a mother. I've got two daughters. I was circ'ed as a girl, as were both of my daughters. I asked all the questions -- is it necessary, is it recommended, why or why not, etc. I decided to go ahead and I know exactly why I made that choice based on scientific data. If someone else is informed of the scientific data and chooses against circumcision, I fully respect that and have no problem with it. I can tell you that the child displayed little evidence of pain, as I was right there with the doc as it was done, and it heals quite quickly. And no, not "everybody else" does it. The number of uncircumcised females in the US is increasing, actually. You might find the numbers surprising if you have time to look it up.

    14. Re:Perfect explanation by misexistentialist · · Score: 1

      Because when the kid is old enough to decide to get circumcised, he will want it to have happened when he was an infant, while if he is circumcised he won't know what he is missing. Choosing to circumcise is thus the easy choice despite its irreversibility; and parents will make many more arbitrary yet momentous decisions for their children.

    15. Re:Perfect explanation by garompeta · · Score: 1

      WTF, Seriously... following your logic you saying that the glans only has 10% of the nerve endings on the penis? So under your supposition, then if I ablate my glans and keep my foreskin I can still achieve orgasms? Are you in elementary school? Or you cheated on the male anatomy exam? (lol)

    16. Re:Perfect explanation by girlintraining · · Score: 1, Offtopic

      can tell you that the child displayed little evidence of pain, as I was right there with the doc as it was done, and it heals quite quickly.

      Liar. It hurts -- a lot. [Warning: Link is to a surgical demonstration video of the circumcision of a male baby.]

      And no, not "everybody else" does it. The number of uncircumsized males in the US is increasing, actually. You might find the numbers surprising if you have time to look it up.

      I did.

      Which, by your admission, is a tremendously small number of the male population. And if you become suicidally depressed because you're having disappointing intercourse, I'm guessing it's not just about the intercourse.

      You wouldn't know... you've never had sex with your foreskin intact.

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    17. Re:Perfect explanation by keeboo · · Score: 1

      It's been said that circumcision reduces the chances of STDs and cancer for both partners.

      Have you heard about... how's that called... ah, "basic hygiene"?
      Water, soap... Wash it at least once a day.

      Now if you're having sex with random women (or men, if that applies) and you do not take the proper precautions, being circumcised won't save you from STDs.

      Second, many women prefer cut men because it's "cleaner" when performing fellatio.

      I've never heard complaints. I admit, though, that circumcision is rather rare where I live.
      Unless the guy is particularly unhygienic, I don't think that women can complain, considering it applies the other way around too.

      Third, I've read stories that circumcised men also "last longer" in bed because the feeling isn't as intense for them compared to an uncircumcised man.

      If you've got severe problems with premature ejaculation it might sound like a good idea.
      As for me, I would rather keep my parts intact and enjoy the moment.

    18. Re:Perfect explanation by girlintraining · · Score: 1

      Choosing to circumcise is thus the easy choice despite its irreversibility; and parents will make many more arbitrary yet momentous decisions for their children.

      It's a lie to perpetuate stereotypes -- just like how we flip coins to determine the sex of intersexed babies. Sometimes the doctor doesn't even tell the parents. And every now and then, we make a mistake -- but we don't want to admit it because it's socially acceptable and to question circumcision is tandamount to questioning the church.

      --
      #fuckbeta #iamslashdot #dicemustdie
    19. Re:Perfect explanation by 0100010001010011 · · Score: 1

      1) Condoms reduce the chance of STDs more. Maybe be a responsible parent and teach your kids about condoms instead of sticking your fingers in your years.
      2) It's the 21st century. I have a shower. I shower first as does my girlfriend before I. I've never heard one complaint about 'preference' or liking it 'the other way'
      3) I've heard stories that they don't. It's circumstantial (no pun) evidence. I last plenty long for my girlfriend.

    20. Re:Perfect explanation by MindlessAutomata · · Score: 1

      There should be no reason we are forcing Jewish/Muslim genital mutilation on children. For one, it tortures the infant. It's a very unnecessary and painful procedure, it's strange that you can't torture children with unneeded electrical shocks or other abuse yet you can slice baby genitals and get away with it under the guise of "cosmetics."

    21. Re:Perfect explanation by sexconker · · Score: 1

      They cut it off so they can sell it to cosmetics manufacturers.

      Yes ladies, your makeup has foreskin in it.

      Rub those cocks all over your faces.

    22. Re:Perfect explanation by tsalmark · · Score: 1, Redundant

      Isn't the number of uncircumcised females in the US almost 100%, at least outside of immigrants?

    23. Re:Perfect explanation by sexconker · · Score: 2, Insightful

      I asked all the questions

      And did you get the real answers?

      is it necessary

      No, it is unnecessary

      is it recommended

      Yes, it is recommended

      why

      Because they can charge you for it, and then sell the foreskin.

      You made the choice based on scientific data?
      Which data? The data showing almost zero correlation between circumcision and reduced health risks?

      It's mutilation. It's wrong. It should be illegal.

    24. Re:Perfect explanation by sexconker · · Score: 1

      The reduced chance of STDs, the improved hygiene, etc is not due to the circumcision.

      It's due to the fact that people (parents) who are more concerned about health will be more likely to circumcise their child (based on the bullshit claims that it's healthier).

      Health-conscious people circumcise their kids, who are also health-conscious people.

      Circumcision does NOT provide any mechanism to improve hygiene. All it provides is a risk for infection or terrible mishap.

      Anyone unhygienic enough to get nasty funk trapped under their foreskin is going to by unhygienic enough to get nasty gunk on the rest of their cock.

      Sex is NOT better for the male, it's worse. It lasts longer because there are millions of nerves lost, and the constantly-exposed head becomes calloused.

      Cleaner when performing fellatio? Seems to me foreskin is pulled back, behind the head. A penis with the foreskin pulled back looks exactly like a circumcised penis, with the notable exception that the head isn't a thick, rough callous.

    25. Re:Perfect explanation by Anonymous Coward · · Score: 0

      As somebody who, because of a medical condition, had to be circumcised at the age of seven, I would have much preferred my parents chose to do it right off the bat.

    26. Re:Perfect explanation by MartinSchou · · Score: 1

      So why not have the doctors remove the spleen, tonsils and appendix from infants as well?

      I'm pretty sure that anyone who had to have had those removed would have preferred having it done to them, at a time of their life they have no way of remembering.

    27. Re:Perfect explanation by studog-slashdot · · Score: 1

      I decided to go ahead, and I know exactly why I made that choice based on scientific data. If someone else is informed of the scientific data and chooses against circumcision, I fully respect that and have no problem with it.

      I am struggling with this decision for my son; can you please provide the scientific data?

      Having viewed the circumcision video posted elsethread, right now I'm thinking no.

      ...Stu

    28. Re:Perfect explanation by Kozz · · Score: 1

      SELL the foreskin? Sounds like a conspiracy theory to me. These procedures took place at a highly accredited hospital by a pediatrician chosen by myself and my wife, under my observation. Not saying it's not possible, but seems extremely unlikely.

      Zero correlation? You must be citing only the studies that support your position.

      Mutilation? That's pretty extreme language. If the procedure were taking place on a different part of the body (but for similarly supported reasons), I suppose you wouldn't object so loudly.

      --
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    29. Re:Perfect explanation by Kozz · · Score: 1

      Fuck... "plastic surgery" suggests my motivation was cosmetic. Not!

      "Amputation"? Seems like yet another charged word.

      --
      I only post comments when someone on the internet is wrong.
    30. Re:Perfect explanation by im_thatoneguy · · Score: 2, Insightful

      The Parent is confusing because it was a bit of lazy satire parodying a post above it which wasn't modded high enough to be visible. The parent replaced "Father" with "Mother" and "Sons" with "Daughters".

    31. Re:Perfect explanation by NiteShaed · · Score: 1

      Gee, didn't take long for this to come out. Do you really see the removal of a girl's clitoris and possibly labia as being analogous to removing the foreskin? I was circumcised, and I can assure you I enjoy sex just fine. Is it possible that it would be even better had I not been circumcised? Maybe, but I have a hard time envisioning how it could be, cause it's pretty frackin' great as-is. I doubt a woman who's had her clitoris removed would have a similar attitude towards sex.

      Please don't trivialize the kind of suffering that those girls are put through. If you find a culture where it's common to remove most of the penis, you may be on to something, but foreskin vs. clitoris and labia seems like no contest.

      Further, I've never heard any "scientific data" supporting female "circumcision", but there is scientific data supporting it for males.

      --
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    32. Re:Perfect explanation by Kozz · · Score: 1

      Liar. It hurts -- a lot

      Re: pain -- they were given anesthesia, mmm-kay?

      I did [cirp.org].

      Quite the unbiased source you've got there.

      You wouldn't know... you've never had sex with your foreskin intact.

      Followed up with an ad hominem. Brilliant.

      --
      I only post comments when someone on the internet is wrong.
    33. Re:Perfect explanation by Kozz · · Score: 1

      If the penis and vagina were indistinguishable in form and function, you might have a point. But reversing the genders of my statement has got to be the most absurd counterpoint in the whole thread.

      --
      I only post comments when someone on the internet is wrong.
    34. Re:Perfect explanation by tsalmark · · Score: 1

      Thanks, I swear I tried to hit "Parent" to make sense of it, must have missed.

    35. Re:Perfect explanation by grcumb · · Score: 1

      I wonder if that is the problem Tiger Woods has. He obviously was thinking with the wrong head.

      Exactly. He used his wood when he really needed a driver.

      --
      Crumb's Corollary: Never bring a knife to a bun fight.
    36. Re:Perfect explanation by interkin3tic · · Score: 1

      The foreskin contains about 90% of the nerve endings on the penis.

      So I'd have more nerves to stimulate down there, and be even less than a one minute man if I hadn't been circumsized? Thanks Mom and Dad!

    37. Re:Perfect explanation by Anonymous Coward · · Score: 0

      You wouldn't know... you've never had sex with your foreskin intact.

      And neither have you, girlintraining, self-proclaimed "dyke".

    38. Re:Perfect explanation by Onymous+Coward · · Score: 1

      Third, I've read stories that circumcised men also "last longer" in bed because the feeling isn't as intense for them compared to an uncircumcised man.

      This is a selling point?

      If you think making your penis less sensitive is best way to last longer in bed...

      I'm afraid to imagine other problems you've got solutions for.

    39. Re:Perfect explanation by phantomcircuit · · Score: 1

      Isn't the number of uncircumcised females in the US almost 100%, at least outside of immigrants?

      Yes because performing a female circumcision in the US is a SERIOUS FEDERAL CRIME.

    40. Re:Perfect explanation by Kozz · · Score: 1

      I decided to go ahead, and I know exactly why I made that choice based on scientific data. If someone else is informed of the scientific data and chooses against circumcision, I fully respect that and have no problem with it.

      I am struggling with this decision for my son; can you please provide the scientific data?

      Having viewed the circumcision video posted elsethread, right now I'm thinking no.

      ...Stu

      The procedure is by no means a pleasant thing to view, but that video is far from the truth I witnessed twice. That video DOES in fact look pretty barbaric. I think I might have throttled that doctor myself if I'd been there. It's no wonder the anti-circ crowd wants to use THAT as their propaganda. You want a run-down of the procedure itself?

      Diaper removal. Doc hands me a small creamer-sized container of sugar water, into which I intermittently dip my (gloved) pinky, and my son happily sucks/drinks the sweetness. Puts him at ease a bit, during which time the pediatrician uses a small needle to administer an anesthetic nerve block on the groin area once on each side of the base of the penis.

      Give a minute or two for the nerve block to do its thing, while giving sugar water. Baby sucks/drinks, but never cries (neither of them did). See the last paragraph of this section:
      http://en.wikipedia.org/wiki/Circumcision#Pain%20and%20pain%20relief
      It describes exactly what procedure my sons received. Maximum pain relief possible. And the procedure my boys had looks a whole LOT more like what you can see here:
      http://newborns.stanford.edu/Gomco.html

      Keep in mind that I had a very experienced pediatrician who's done hundreds in the duration of his practice, and each procedure was less than 10min.

      As for the science, you can ask your pediatrician or doctor about the benefits in terms of infections and STD compared with those of uncircumsized individuals. I can't quote numbers, because it's been 4yrs since I had that discussion with my pediatrician and can't recite the data from memory. For us, it was also a matter of the boys feeling confident in themselves when they know they look "the same as daddy" (I expect all who have never made this decision to balk at the thought).

      I definitely won't tell you what to do. Get a doc that you trust. Ask for his professional input to make your own decision. Whatever you decide, you're the boss, don't forget it. Best of luck to you!

      --
      I only post comments when someone on the internet is wrong.
    41. Re:Perfect explanation by drkim · · Score: 1

      I was going to make a "...right off the bat." joke, but have chosen not to.

      Carry on.

    42. Re:Perfect explanation by the+biologist · · Score: 1

      eh. these days in reasonable societies, intersex babies are allowed to make their own decision after they reach puberty. Why? Because gender isn't just a physical thing dealing with your genitals, but instead also involves specific brain differences.

    43. Re:Perfect explanation by Anonymous Coward · · Score: 0

      that and its not apples to apples and female "circumcisions" aren't circumcisions, and achieve very different results. For a male sex sometimes becomes -too- pleasurable. That's a different ballgame.

    44. Re:Perfect explanation by DigiShaman · · Score: 1

      Heh, think of it as a nice bonus. Extra time for the sport of it ;) It takes two to play....

      --
      Life is not for the lazy.
    45. Re:Perfect explanation by blai · · Score: 1

      > Some become suicidally depressed.

      [citation needed]

      --
      In soviet Russia, God creates you!
    46. Re:Perfect explanation by Anonymous Coward · · Score: 0

      You'll have to forgive girlintraining. She's endlessly fixated upon her own sexuality, and seems to project that fixation wherever she goes.

    47. Re:Perfect explanation by Trogre · · Score: 1

      In this culture of regular hygienic bathing you're absolutely correct. But send your boys off to war, or any other situation where regular washing isn't an option and see how the uncircumcised manage.

      --
      "Nine times out of ten, starting a fire is not the best way to solve the problem." - my wife
    48. Re:Perfect explanation by MindlessAutomata · · Score: 2, Insightful

      Just fine, I imagine, considering humans evolved like that.

    49. Re:Perfect explanation by Fire_Storm82 · · Score: 1

      I'd like to see your source on that.

    50. Re:Perfect explanation by Anonymous Coward · · Score: 0

      So, you are against ear, nose, tongue, and bellybutton piercings as well, then?

    51. Re:Perfect explanation by Anonymous Coward · · Score: 0

      It is barbaric and should be banned. You cannot treat boys with any less humane dignity than their female counterparts. If an adult man wants to be circumcised, that's his business. If it must be done for medical reasons, that's different.

      Your "scientific data," which you claim to know yet don't share, smells like bull.

      Oh, I know some studies claim it'll help against HIV but, FFS, condoms do not require surgical mutilation to prevent HIV transmission. I don't see you advocating breast removal for your daughter because she won't get cancer. Get a grip. Leave your sons INTACT as nature intended.

    52. Re:Perfect explanation by Trogre · · Score: 1

      I'm pretty sure they didn't evolve wearing pants.

      --
      "Nine times out of ten, starting a fire is not the best way to solve the problem." - my wife
    53. Re:Perfect explanation by Anonymous Coward · · Score: 0

      My understanding is that it's about 50/50 on newborn children in the us now. None the less, barbaric maybe too strong a word, but mutilate may not be.

      Main Entry: mutilate
      Pronunciation: \myü-t-lt\
      Function: transitive verb
      Inflected Form(s): mutilated; mutilating
      Etymology: Latin mutilatus, past participle of mutilare, from mutilus truncated, maimed
      Date: 1534

      1 : to cut up or alter radically so as to make imperfect
      2 : to cut off or permanently destroy a limb or essential part of

      #1 would be too easy to argue, but clearly not what you meant.

      What does essential mean?

      apparently it means so important as to be indispensable. When it comes to the sex organs this is extremely subjective. The comparison between female genital mutilation and circumcision isn't without merit. If one views the purpose of sex organs to be reproduction fgm wouldn't be mutilation either. Regardless, the foreskin of the penis does have a function. It simultaneously protects the mucus membrane of the glans, and provides a gliding ability, with effects similar to additional lubrication. The tissue is permanently destroyed and these functions are lost, resulting in a significant loss of sensation in the mucus membrane. The idea that it's ok when a baby is young because they don't know what they are missing and can't remember the pain is somewhat silly, since a similar argument could be made for any operation, including rather severe things like gouging out one eye or amputating a couple fingers.

    54. Re:Perfect explanation by FreakyGreenLeaky · · Score: 1

      bwahahahahahahahahaha

      /comes up for breath...

      bwahahahahahahahahaha

    55. Re:Perfect explanation by VShael · · Score: 1

      You claim there's scientific data supporting male circumcision.
      It's not as clear-cut (no pun intended) as you make out.

      In 1980, after an exhaustive analysis of the extensive "scientific" data supporting circumcision, Edward Wallerstein, in his book, Circumcision: An American Health Fallacy, exposed the flawed research and researcher bias of that data.

      In 1989, because K.J.S. Anand, M.B.B.S., D.Phil., and P.R. Hickey, M.D., studied babies undergoing circumcision and reported that infants do experience pain (New England Journal of Medicine, November 19, 1987). Their subsequent research indicates that babies undergoing excruciatingly painful procedures are at increased risk of death due to the stress of surgery (NEJM January 2, 1992). In the same journal, Mark C. Rogers, M.D.,
      wrote "One hundred fifty years ago, surgery was performed under brutal conditions. Without benefit of anesthesia, patients endured excruciating pain; indeed, the belief was widespread that they could die from the 'shock' of surgery. With the advent of anesthesia, this primitive and inhumane era passed. Adult patients could expect complete relief of pain during surgical procedures. Unfortunately, infants and children continued to receive inadequate relief of pain or even no treatment for pain during surgical procedures, and this is often still the case..." In the case of unnecessary surgery, the appropriate alternative to anesthesia is not operating.

    56. Re:Perfect explanation by BlueParrot · · Score: 3, Insightful

      I asked all the questions -- is it necessary, is it recommended, why or why not, etc.

      Well here is one you did not consider. About one in every few thousand babies born is transsexual. That is, the neurological gender of their brain does not match the apparent sex of their body. Typically these people will desire surgical "correction" of their genitals latter in life, and availability of skin is one of the key variables that impact the outcome. Now I realize this is a rare occurrence, but it does happen, and since I'm transsexual myself and thus know just how shit it can be, I can only hope that neither of your sons will turn out to be transsexual. Then again, with sufficiently many babies being circ'd it follows that it will happen to some.

      I also imagine it may have an impact on other types of re-constructive surgery, should your sons ever have the misfortune of being hurt in an accident or something.

    57. Re:Perfect explanation by Anonymous Coward · · Score: 0

      :( It is better to have loved and lost than never loves at all.

      so the same could be said...

      It's better to have felt foreskin in action, then never at all....?

      it's an unnecessary, EXPENSIVE, operation. Wasteful. They just throw the foreskin away....

    58. Re:Perfect explanation by olman · · Score: 1

      For the very few men that have been circumsized as an adult and had an opportunity to experience sex both ways -- they say that sex is very disappointing after. Some become suicidally depressed.

      As an male who had his weenie chopped in his 30s, I can say I enjoy sex whole a lot more without the painful splits in the foreskin that take forever to heal and general constriction/pain due to naturally moderately undersized foreskin.

      I only wish public healthcare didn't drag their heels about it for a decade due to general perceptions over here.

    59. Re:Perfect explanation by Anonymous Coward · · Score: 0

      ----------> WHOOSH!

    60. Re:Perfect explanation by xmousex · · Score: 1

      wow that sounds awful. So in the last 50 years, how many thousands of babies do we have on record dying from 'shock' during circumcision?

    61. Re:Perfect explanation by HungryHobo · · Score: 1

      Where did this piece of retardation come from????

      You'd swear that every man with a bit of his dick chopped off thinks that those of us who aren't circumcised have to constantly worry about it rotting off.
      Hygiene has never been an issue for me.
      Ever.

      Not in normal society and not even even when spending weeks hiking cross country without access to easy ways to wash.

      It's a retarded myth.
      A foreskin does not make for hygiene problems.

    62. Re:Perfect explanation by Gorphrim · · Score: 1
      I guess it depends on who you believe.

      from http://www.mayoclinic.com/health/circumcision/PR00040:
      • Decreased risk of urinary tract infections. The risk of urinary tract infections in the first year is low, but these infections may be up to 10 times as common in uncircumcised baby boys. Severe infections early in life can lead to kidney problems later on.
      • Prevention of penile problems. Occasionally, the foreskin on an uncircumcised penis may be difficult or impossible to retract (phimosis). This can also lead to inflammation of the head of the penis.
      • Decreased risk of penile cancer. Although cancer of the penis is rare, it's less common in circumcised men.
      • Decreased risk of sexually transmitted diseases. Safe sexual practices remain essential, but circumcised men may have a slightly lower risk of certain sexually transmitted diseases — including HIV, the virus that causes AIDS.
      --

      Queens of the Stone Age - they rule
    63. Re:Perfect explanation by MartinSchou · · Score: 1

      Are you sure it isn't a very effective way of not only identifying your own fallen, but also ensuring that spies are easily spotted?

      After all, if all the people you fight look like you do, them still having their foreskin makes it pretty easy to tell that they're your enemy.

    64. Re:Perfect explanation by NiteShaed · · Score: 1

      You claim there's scientific data supporting male circumcision.
      It's not as clear-cut (no pun intended) as you make out.

      It's exactly as clear-cut as I say. There is scientific data supporting the beneficial effects of the procedure. You may not find those effects to be worth any risk involved, but that doesn't change the fact that the data is there.

      --
      Some bring out the best in others, some the worst. Some bring out far more.
    65. Re:Perfect explanation by TheLink · · Score: 1
      --
    66. Re:Perfect explanation by sexconker · · Score: 0, Troll

      They sell the foreskin for use in cosmetics.

      There is almost zero correlation. There are just as many studies showing a negative correlation as there are showing a positive one. This is taking ALL studies. Any correlation is MUCH more likely due to the fact that health conscious people are told it's healthier, and therefore choose to do it. Being health-conscious people, their children are less likely to have issues with hygiene, STDs, etc. The converse (less health-conscious people, etc.) is just as true. There is almost zero correlation, correlation does imply causation, but there are much stronger sources of correlation in this case.
      Indeed, the foreskin itself is a natural barrier that protects against damage and disease. It keeps the glands on the corona protected (and alive). The glands secret fluids that clean the head of the penis. A circumcised penis has dead glands and a calloused head. This is to say NOTHING off the risks with the actual procedure itself.

      It is mutilation. It is a permanent, unnecessary procedure. The only person making the decision should be the one who's attached to the penis. I'd object to any similar practice.

    67. Re:Perfect explanation by ringm000 · · Score: 1

      If you could not refute any argument whatsoever by simply refusing to use deductive reasoning because "this is a special case", refusing to use analogies because "this is a special case", and surely refusing to use inductive reasoning because "this is a special case", you might have a point.

    68. Re:Perfect explanation by Kozz · · Score: 1

      wut.

      --
      I only post comments when someone on the internet is wrong.
    69. Re:Perfect explanation by Bengie · · Score: 1

      Technically, the infant can't "feel" pain, it just has knee-jerk reactions to it that increase it's chances of survival. Nothing can really "feel" anything until it becomes self-aware. I don't think your brain develops awareness until sometime after 3 years.

      The other side of it is they have shown benefits of circumcision although usually very minor and more of an issue of lesser clean people.

      Then there's me. I wasn't circumcised until I was 10. Even though I was a clean child, I had reoccuring infections. I don't remember much of when I was young, but I do remember the infections hurting a lot and some times worse than the feeling of a scab getting ripped off my penis while it was healing from the operation.

      At least if I was circumcised as an infant, I would healed several times faster, run MUCH less chance of scare tissue affecting feeling(go go stem cells) and I wouldn't have remembered it at all.

    70. Re:Perfect explanation by negRo_slim · · Score: 1

      What do you consider scarification, tattooing, piercing and whatever the Chinese used to do to women's feet?

      Body Modification

      And when you think about it; I'm not sure I'm the only Slashdotter that wouldn't mind an SD slot integrated unto my cranium.

      So fundamentally what's the difference between that and circumcision? I know a long shot, but then again so is calling it mutilation.

      --
      On the Oregon Cost born and raised, On the beach is where I spent most of my days
    71. Re:Perfect explanation by MartinSchou · · Score: 1

      Fuck... "plastic surgery" suggests my motivation was cosmetic. Not!

      Cosmetic or not, with no real medical reason, you are altering someone's appearance. And as for the idea preventative surgery to remove an unnecessary piece of the body, why not take out his tonsils as well? That can be done without major surgery, which you obviously cannot do with the appendix.

      "Amputation"? Seems like yet another charged word.

      "Amputation is the removal of a body extremity by trauma or surgery"
      [...]
      "The word amputation is derived from the Latin amputare, "to cut away""

      Foreskin certainly looks like an extremity to me. It's not very large, true. And it's attached to an extremity, but if you get the distal phalanges removed, it's still an amputation, and it's an extremity attached to an extremity (the finger), attached to an extremity (the hand), attached to an extremity (the arm).

      But let's look at what the Official Journal of the American Academy of Pediatrics says on the subject:
      Page 4: "and amputation of the foreskin"

      But hey, doctors always use charged words that aren't the proper description of their procedure. That's why they call it baby-murder instead of an abortion.

    72. Re:Perfect explanation by DrGamez · · Score: 1

      If it's with their consent, I call it the same thing as I call circumcision at that point: body modification with consent. When it's done with no consent from the person whom the operation is being performed, then it's done to please others, which should be considered something else, perhaps not mutilation.

    73. Re:Perfect explanation by badkarmadayaccount · · Score: 1

      Secure Digital has DRM support. CF does not, and uses bog standard ATA protocol. Turn in your geek card. Then do it again, because you didn't say CFast, that is based of the SATA spec.

      --
      I know tobacco is bad for you, so I smoke weed with crack.
    74. Re:Perfect explanation by badkarmadayaccount · · Score: 1

      How is this a troll?

      --
      I know tobacco is bad for you, so I smoke weed with crack.
    75. Re:Perfect explanation by Bengie · · Score: 1

      because removing any of those on a child before adolescence could have detrimental affects to their health...? Not so much the appendix, but any operation that involves cutting open runs a much greater chance of death, not to mention how expensive that would be. Circumcision has been done for thousands of years. Thousands of years ago, any removal of organs was a death sentence. The appendix does help maintain healthy bacteria, especially after diarrhea. This could be more important for younger children to.

  4. That's awesome! by stakovahflow · · Score: 3, Insightful

    I'm happy for those with MS & Macular Degeneration...
    There is Hope!

    (Just not the "Obama" kind of hope...)

    I'm curious...

    Is this possibly a cure for Alzheimers, as well?

    --
    Holy happy hippy crap!
    1. Re:That's awesome! by Em+Emalb · · Score: 1

      Dude, did you not even read the summary?

      I'm lazy, so usually I don't before I write some knee-jerk reactionary crap, but I thought I was alone in that.

      (Note I'm saying "I" write that stuff, not you.)

      --
      Sent from your iPad.
    2. Re:That's awesome! by some_guy_88 · · Score: 1

      Does this mean I can consume as much alcohol as I like now and let my doctor in the future grow back my brain cells?

      I'll drink to that.

    3. Re:That's awesome! by wizardforce · · Score: 4, Informative

      Is this possibly a cure for Alzheimers, as well?

      No. The beta-amyloid plaques that damage and ultimately kill bain cells would still be present. The plaques themselves must be destroyed, not just throw billions of new neurons at the problem.

      --
      Sigs are too short to say anything truly profound so read the above post instead.
    4. Re:That's awesome! by Jon+Taylor · · Score: 3, Insightful

      If the beta-amyloid plaques do ultimately kill the brain cells, what could be gained by removing them? AFAIK the only decent route out and away from Alzheimer's is to synthesize replacement brain tissue via new neurons AND new glial cells, and then somehow retrain the brain to use the new nervous tissue to 'route around' the damaged areas. Stroke victims often undergo years of intensive retraining in order to relearn how to walk and talk, etc., which shows that the retraining approach works in principle to fix arbitrary types of brain damage. But, you have to have somewhere for the training to go, which is why the prospect of well-engineered replacement nervous tissue is so important. IMHO, it could in fact very well become part of an Azheimer's cure.

    5. Re:That's awesome! by cytoman · · Score: 1

      I guess...but what about the lost memories?

    6. Re:That's awesome! by Hurricane78 · · Score: 2, Funny

      I’m happy for those with MS & Macular Degeneration...

      Yes. MS is a really ugly disease. You get this colorful “buttons” all over the surface, and it gets harder and harder to to basic stuff. You basically become a dumbed-down zombie after a time, unable to achieve anything. Locked down in your cage of point and click on Playmobil interfaces giving you macular degeneration.
      Thank god for Linux.

      --
      Any sufficiently advanced intelligence is indistinguishable from stupidity.
    7. Re:That's awesome! by rdnetto · · Score: 1

      The plaques themselves must be destroyed, not just throw billions of new neurons at the problem.

      I don't know, most problems could (probably) be solved id billions of new neurons were thrown at them.

      --
      Most human behaviour can be explained in terms of identity.
    8. Re:That's awesome! by badkarmadayaccount · · Score: 1

      Good riddance.

      --
      I know tobacco is bad for you, so I smoke weed with crack.
  5. Cheers! by Anonymous Coward · · Score: 5, Funny

    Neurons have been created directly from skin cells for the first time.

    This research counters all the arguments that people shouldn't do drugs because they kill brain cells. Now that we know how to create new brain cells, there is no excuse for not being stoned. And bike riders can now throw away there helmets. Science brings freedom back to democracy.

    1. Re:Cheers! by Anonymous Coward · · Score: 1, Funny

      "there helmets"? You were trying to be funny or perhaps you need some new brain cells.

    2. Re:Cheers! by Hurricane78 · · Score: 1

      As long as you are OK with forgetting everything you know, and basically becoming a new person...

      Because you sure won’t get back your old dendrites. And if 10% of your brain cells are wrecked beyond repair from drugs, I’ll sign you a statement, saying that the other 90% are at least very close to it too.

      --
      Any sufficiently advanced intelligence is indistinguishable from stupidity.
  6. What to do with neuron cells by HeckRuler · · Score: 1

    So, AWESOME!

    Uh, do we have anyway to implant vat grown neurons into people in some meaningful way? Can we actually attach vat grown neurons to, uh, other neurons?
    This is going to be one of those "wait 5 years" breakthroughs isn't it?

  7. Cost-benefit analysis by handy_vandal · · Score: 0

    ... there is no excuse for not being stoned.

    Oh yes there is: it's too expensive.

    --
    -kgj
    1. Re:Cost-benefit analysis by badkarmadayaccount · · Score: 1

      Legalize it and that won't be a problem either.

      --
      I know tobacco is bad for you, so I smoke weed with crack.
  8. So... how long... by mafian911 · · Score: 5, Funny

    ...until this technology can be used to regrow luscious locks of hair for balding people? Just asking... for a friend... .

    1. Re:So... how long... by interkin3tic · · Score: 2, Funny

      I could be wrong, but I think I remember hearing that male pattern baldness wasn't caused by a loss of hair follicle stem cells, it was caused by a loss of signaling in the niche the hair cells reside in.

      I guess it's possible that induced pluripotent stem cells could be used to make new scalp, including the niches, and then you could put that on, essentially resetting the clock so you'd have 20 or so more years of hair.

      (Disclaimer, I heard a seminar on baldness and stem cells over a year ago, so that could be outdated in addition to partially forgotten. Don't clone yourself, scalp him, and then sue me because you went bald in under a year.)

    2. Re:So... how long... by Anonymous Coward · · Score: 0

      Try Finasteride*. Male pattern baldness is caused by the fair follicules being sensitive to dihydrotestosterone (DHT). Dihydrotestosterone is a metabolite of testosterone (T). Finasteride is a type II 5-alpha reductase inhibitor, which is the ensyme that converts T to DHT.

      The least Finasteride will do for you is prevent further hair loss, and many people have regrowth. I've been taking 2.5mg/day for 1.5 months and I can see regrowth. As a rule of thumb, my physician says that hair lost within the past 5 years will usually regrow, there will be some regrowth of hair lost between 5 years and 10 years ago, and no regrowth of hair lost more than 10 years ago.

      To find the peer reviewed research search google schollar for: finasteride androgenetic alopecia

      You may also want to investigate minoxidil (too messy and too much hassle for me) and Nizoral. There was some research done which showed Nizoral shampoo (2% Ketoconazole) increased the number of anagen phase hair growth in mice. Finasteride however is the only FDA licensed product for the treatment of androgenetic alopecia (Male pattern baldness) at this time.

      *under the care of a competent physician

  9. Re:Fetal Stem Cells Need Not Apply by BobMcD · · Score: 2, Insightful

    If the implications pan out, not much longer.

    I like stem cells, but feel that abortion is the most sensitive of issues and ought to remain free of any profit motive.

    To me this breakthrough seems like a win-win.

  10. And people still bitch... by Anonymous Coward · · Score: 0

    And people still bitch about the ban of embryonic stem cells. If we think of it, the ban actually spurs research to a much better direction.

    1. Re:And people still bitch... by net28573 · · Score: 1

      If we work with what we have when we have it then we can improve upon it while also researching other potential ways to do it. So if embryonic stem cell research hadnt been banned then we could have had our head scientists working on it while the rest of em try and find other ways to do it. either way with the ban we have lost a potential of getting important work done faster with people that know what they are doing rather than work at the slow pace of searching what would seem like grains of sand for the potential answer or alternative (waste of time).

      --
      RIP TRICERATOPS, YOU NEVER EXISTED
  11. clearly scientists know nothing about marketing by rev_sanchez · · Score: 4, Funny

    Sick people don't have money because they spend it all on hospitals and medicine but horny old fat people have tons of money. If Dr. Jack wants some serious grant money he'd better try to turn fat cells in boner cells. He can use some of that cash to help him make Michael J. Fox less shaky and hell, why not give him a giant wang while he's at it.

    He'd be great in a commercial, "Hi, I'm Michael J. Fox. You may have noticed that I'm a lot less shaky these days and I also have a giant wang now. I owe it all to Dr. Jack." Boom! Instant Nobel Prize.

    --
    If you didn't come to party don't bother knocking on my door. Prince '1999'
    1. Re:clearly scientists know nothing about marketing by couchslug · · Score: 2, Funny

      "horny old fat people have tons of money."

      This "money" of which you speak, when do I get it?

      --
      "This post is an artistic work of fiction and falsehood. Only a fool would take anything posted here as fact."
  12. Embryonic stem cells shouldn't be replaced by LockeOnLogic · · Score: 4, Informative

    There are no "workarounds" in the need for embryonic stem cells. Each approach and method of stem cell generation have their respective strengths and weaknesses

    1. Re:Embryonic stem cells shouldn't be replaced by amiga3D · · Score: 3, Interesting

      Really now. If what these guys are saying is true and any cells can be reprogrammed. What's the big benefit of harvesting embryo's?

    2. Re:Embryonic stem cells shouldn't be replaced by jgtg32a · · Score: 3, Insightful

      I'm sorry there was a "need" for embryonic stem cells? Was there a break through that I missed? I was under the impression that embryonic cells would be great because they can be turned into anything, and are ready to go right after they are harvested, but they have a very high rejection rate and have been known to introduce other problems.
       
      That's why all techniques using stem cells use adult stem cells.

    3. Re:Embryonic stem cells shouldn't be replaced by jellomizer · · Score: 1

      Is this because of Real Science concerns or just because there is a group of people who don't like embryonic stem cells for religious reasons.

      If you can get your research done without a bunch of rabid bible thumpers yelling at you... All the better...

      If you are pushing continuing the process because of political reasons or because you just don't want to loose then it isn't science.

      --
      If something is so important that you feel the need to post it on the internet... It probably isn't that important.
    4. Re:Embryonic stem cells shouldn't be replaced by BJ_Covert_Action · · Score: 1

      It encourages an evil science and evil men. Evil men grow nice, dark, slicked mustaches. QED, harvesting babies for their stem cells increases the mustache:nonmustache ratio in the world. Therefore, it benefits mankind.

      =P

    5. Re:Embryonic stem cells shouldn't be replaced by TubeSteak · · Score: 4, Insightful

      Really now. If what these guys are saying is true and any cells can be reprogrammed. What's the big benefit of harvesting embryo's?

      What's the big benefit of incinerating them as medical waste?

      Medical ethics and Religious ethics should remain separate. Point in case:
      Go back a few hundred years and the study of anatomy was called "desecrating a corpse".
      Our monkey curiosity has gotten us this far, lets not be arbitrary about what we keep doing with it.

      --
      [Fuck Beta]
      o0t!
    6. Re:Embryonic stem cells shouldn't be replaced by abigor · · Score: 2, Funny

      Yes, apparently there was a bunch of stuff that you missed. Don't worry about it though.

    7. Re:Embryonic stem cells shouldn't be replaced by TheTyrannyOfForcedRe · · Score: 1

      Really now. If what these guys are saying is true and any cells can be reprogrammed. What's the big benefit of harvesting embryo's?

      They're fun to make and even more fun to "harvest."

      MMMmmmmmmmmmmmm...embryos!

      --
      "Liechtenstein is the world's largest producer of sausage casings, potassium storage units, and false teeth."
    8. Re:Embryonic stem cells shouldn't be replaced by Anonymous Coward · · Score: 0

      Stem cells can be harvested from breast milk and umbilical cord blood. Personally while I don't like the 'moo' factor, breast milk would seem far more easily obtainable than embryos.

    9. Re:Embryonic stem cells shouldn't be replaced by izomiac · · Score: 1

      You're conflating research with clinical practice. In research the embryonic cells are vastly easier to work with, which hastens progress, reduces expense, and eliminates one source of errors. Clinically, adult stem cells are more useful since a person could receive transplants that were immunologically indistinguishable from their own body, thus negating the need for immunosupressants and reducing the need for organ donors.

    10. Re:Embryonic stem cells shouldn't be replaced by cytoman · · Score: 1

      LOL! I loved this response! I'm definitely stealing it for my own use :-).

    11. Re:Embryonic stem cells shouldn't be replaced by Attila+Dimedici · · Score: 1

      There are no "workarounds" in the need for embryonic stem cells. Each approach and method of stem cell generation have their respective strengths and weaknesses

      What "need" for embryonic stem cells? Can you tell me of one successful therapeutic use for embryonic stem cells?

      --
      The truth is that all men having power ought to be mistrusted. James Madison
    12. Re:Embryonic stem cells shouldn't be replaced by interkin3tic · · Score: 1

      What's the big benefit of harvesting embryo's?

      A man's gotta have hobbies.

      That, and they still are good for research. If you want to study human cell biology, like how the embryo makes liver cells initially, this is an easier way.

    13. Re:Embryonic stem cells shouldn't be replaced by Draek · · Score: 3, Insightful

      Except it's not "religious ethics", it's simply ethics of people who have chosen to define the start of a human's life sooner than others.

      --
      No problem is insoluble in all conceivable circumstances.
    14. Re:Embryonic stem cells shouldn't be replaced by chickenarise · · Score: 3, Insightful

      Except we aren't talking about living things, we are talking about dead things. Dead things that would be burned, rather than used for research.

      --
      One convenient locations...in Africa.
    15. Re:Embryonic stem cells shouldn't be replaced by Anonymous Coward · · Score: 1, Insightful

      Predicated on the idea that a clump of cells, with the potential to become a human, already possesses a soul. I call bullshit.

    16. Re:Embryonic stem cells shouldn't be replaced by newhoggy · · Score: 1

      Really now. If what these guys are saying is true and any cells can be reprogrammed. What's the big benefit of harvesting embryo's?

      The original argument against embryonic stem cell research was that is either is potential for life or is life and that killing an embryo is killing life.

      If embryonic stem cells and skin cells are really interchangeable, then perhaps skin cells have the potential for life as well.

      In that case what is the difference if we work on embryonic stem cells or skin cells?

    17. Re:Embryonic stem cells shouldn't be replaced by Draek · · Score: 1

      Same goes for the organs of dead people, yet there's plenty of ethical issues with simply harvesting them without consent.

      --
      No problem is insoluble in all conceivable circumstances.
    18. Re:Embryonic stem cells shouldn't be replaced by maxwell+demon · · Score: 1

      If I understand it correctly, strictly speaking it's not even reprogramming; each cell already contains the genetic program of the complete organism. What they managed is to activate the parts belonging to another cell type instead of the parts belonging to the current cell types, thus changing the cell into another cell type. Think of rebooting a dual-boot computer to the other OS: Both OSs were already on the hard disk; it was just that only one was active.

      --
      The Tao of math: The numbers you can count are not the real numbers.
    19. Re:Embryonic stem cells shouldn't be replaced by maxwell+demon · · Score: 1

      No, we are speaking of living things. Dead stem cells are useless. However we speak of living things which would be killed otherwise.

      --
      The Tao of math: The numbers you can count are not the real numbers.
    20. Re:Embryonic stem cells shouldn't be replaced by maxwell+demon · · Score: 1

      Killing skin cells very definitely is killing life, too. However, killing a fly also is killing life (and very clearly so), yet few people have any ethical problems to do so. The special point with human embryos is that they would normally develop into a complete human if no one interfered. And since most people agree that killing humans is evil, there's the problem of when exactly the collection of cells starts to be a human. Different people give different answers to this. If you consider the embryo as a human, then taking it apart to experiment with its cells is evil. If you consider the embryo as just a collection of human cells, experimenting with embryonic cells isn't any more problematic than experimenting with blood cells or skin cells.

      Another interesting thought: What if the embryonic stem cells wouldn't be taken from aborted embryos, but taken from embryos created with in-vitro fertilization, and the rest of the embryo was then implanted to grow to a full human (and let's assume that there are no negative effects of this for the human grown from the embryo). Would that now be ethical (because, after all, there was no killing of an embryo involved, just taking away a single cell) or not (because the removed cell in principle would have the potential to grow into a twin of the original embryo, even if that twin wouldn't have existed if the cell had been left in the embryo to begin with).

      --
      The Tao of math: The numbers you can count are not the real numbers.
    21. Re:Embryonic stem cells shouldn't be replaced by maxwell+demon · · Score: 1

      It's because of ethical concerns.

      If you think researchers should not care about ethical concerns, you surely wouldn't mind if some researcher uses you for a lethal experiment which advances science, right?

      --
      The Tao of math: The numbers you can count are not the real numbers.
    22. Re:Embryonic stem cells shouldn't be replaced by cparker15 · · Score: 1

      Less work?

      --
      Have you driven a fnord... lately?

      You must wait a little bit before using this resource; please try again later.

    23. Re:Embryonic stem cells shouldn't be replaced by amiga3D · · Score: 1

      Well there's no proof the soul exists. You can call bullshit if you like. Methinks however that without soul there is no real humanity. Just an empty pointless existence. That's pretty bleak, hence why most people believe in some sort of soul...some inner being that exists in us. Whether it exists or not, I believe that for any sort of civilization to exist most people must believe in it to some point. Without a soul I'm just an animal with animal survival instincts and willing to do anything whatsoever that I believe I can get away with. After all....once I'm dead it wont matter anyway. Imagine 6 billion people that believe that way. What kind of society is that?

    24. Re:Embryonic stem cells shouldn't be replaced by badkarmadayaccount · · Score: 1

      A rational one.
      BTW, anybody having to click twice on the Reply button to get it to register under FF 3.6. I'm also getting something like tearing when the comment field expands.

      --
      I know tobacco is bad for you, so I smoke weed with crack.
  13. Re:Fetal Stem Cells Need Not Apply by girlintraining · · Score: 1

    I like stem cells, but feel that abortion is the most sensitive of issues and ought to remain free of any profit motive.

    It's cost us years, possibly as much as a decade, of research time because of religious considerations. In many cases, aborted fetuses wouldn't survive to term anyway, or are a threat to the mother's health -- but many consider that it has to be a baby or nothing at all. It's that kind of black-and-white thinking that has no place in serious discussions of biology -- Nature does not tolerate black and white. It is a very grey and organic process, where few hard lines can be drawn.

    --
    #fuckbeta #iamslashdot #dicemustdie
  14. The Thing by Anonymous Coward · · Score: 0

    Great... its The Thing.

  15. So: sweet by HeckRuler · · Score: 4, Funny

    Fine, fine, I accept the mod. I still say eating babies is funny, but there's no excuse for misspelling "smartest". That's just dum.

    1. Re:So: sweet by net28573 · · Score: 1

      I'm kinda curious as to why you were modded insightfull and not funny. I would assume you were trying to be funny because you mispelled the word dumb. Either you were trying to be funny or... XD (rotflmao).

      --
      RIP TRICERATOPS, YOU NEVER EXISTED
  16. Re:Fetal Stem Cells Need Not Apply by Hatta · · Score: 3, Insightful

    If you never do research with fetal stem cells, you'll never know what they can do. When the alternative to fetal stem cell research is throwing the fetal stem cells in an incinerator, don't we have a moral obligation to get the best use out of them that we can?

    --
    Give me Classic Slashdot or give me death!
  17. I've heard of wearing your heart on your sleeve... by Falstaft · · Score: 3, Funny

    ...but your brain?

  18. Cancer incidence by dreamer.redeemer · · Score: 2, Informative

    Emphasis on directly, we've been able to coax human adult somatic cells to become pluripotent stem cells since 2007. The "ethical issues" are pretty much old news, bringing it up almost feels like troll bait. TFA suggests that these cells are much less prone to cancer than iPSCs, which seems like a rather important bit the summary omitted.

    --
    the most powerful intellect is that unbounded by indubitable preconception
  19. Re:Fetal Stem Cells Need Not Apply by JoshuaZ · · Score: 1

    All of the work with adult cells relies on our deep understanding from the much easier case of fetal cells.

  20. Cell Wars. by Anonymous Coward · · Score: 0

    "The article also points out that this method could work around the ethical issues surrounding embryonic stem-cell research."

    Would we have had this development if there hadn't been any ethical issues with embryonic stem cells?

  21. Religious issue by cytoman · · Score: 3, Insightful

    The article also points out that this method could work around the ethical issues surrounding embryonic stem-cell research.

    This is more a religious issue rather than ethical - much like the pro-choice and anti-choice debate. Same people are anti-stem cell as those who are anti-choice.

    1. Re:Religious issue by jgtg32a · · Score: 2, Interesting

      I'm against abortion and I'm for stem cells, just not the embryonic variety

    2. Re:Religious issue by cytoman · · Score: 1

      This illustrates my point above. Thanks.

    3. Re:Religious issue by jgtg32a · · Score: 1

      No it doesn't you've completely missed my point

    4. Re:Religious issue by cytoman · · Score: 0, Flamebait

      Another example to drive home my point: The same people who are anti choice also distinguish between "embryonic" stem cells and stem cells, and the same people "accept microevolution" but not "macroevolution". Now, there are always exceptions to such generalizations but broadly, religious people are anti-science and anti-progress.

    5. Re:Religious issue by chickenarise · · Score: 1

      Now, there are always exceptions to such generalizations but broadly, religious people are anti-science and anti-progress.

      And as jgtg32a has shown, pro-thick-headedness. I can't believe it took you 3 posts for him to understand your point...

      --
      One convenient locations...in Africa.
    6. Re:Religious issue by The+End+Of+Days · · Score: 1

      Why not just be honest and label the sides pro-abortion and anti-abortion? I get the idea that you have to present your ideas using the most favorable words possible in order to make it seem like you are naturally correct, but we're almost all adults here so let's not play intellectually dishonest games.

    7. Re:Religious issue by cytoman · · Score: 1
      Pro-choice and anti-choice. Nobody is pro-abortion. But the choice should be with the person who is pregnant. If you try to take that choice away, then you are anti-choice.

      I was objecting to the use of the word "ethical" in describing the debate because ethics has nothing to do with it. There is no dishonesty in my posts. I'm being as clear as can be. The only dishonesty seems to be from those who oppose stem cells and those who are anti-choice - incidentally one and the same group.

    8. Re:Religious issue by Anonymous Coward · · Score: 0

      Coincidentally, there are biblical reasons that abortion is no big deal. More compelling than the ones against. Religious reasons are all pretty weak. If I'm going to support a law in either direction I want more.

      Scientifically, I have no trouble with abortion either. It's just cells.

      Ethically, I have trouble with it. The "just cells" argument applies to you and me as well, so there needs to be a better definition of what constitutes a human life. Religion based ones are weak, so let's not even bother with those. Unfortunately, every definition I hear is arbitrary. In mankind's history, we've used arbitrary definitions of what is human to do some pretty terrible things. "Slaves, well, they aren't human." "Jews, well, they aren't human." "Women, well, they aren't as fully human as men." And so on. I'd rather have a broad definition of what is human and be wrong than have a narrow one and be wrong.

      So if the definition is hazy, how about rights? Rights of the woman vs rights of the fetus.

      Right of choice: Unless it was forced sex, the choice was made to risk pregnancy. You smoke, you might get lung cancer. But the difference is that lung cancer most certainly has no rights. Choice after sex is a pretty lame reason.

      Economic/social/population reasons: weird as it seems, I'd buy those reasons. But feel kind of dirty doing it. Bringing a child into a world only to suffer seems wrong. But it would have to be a pretty shitty existence.

      Every child a wanted child: sorry, but the worth of a person should not be predicated on them being wanted.

      Privacy: A good argument only if we can assert that only one person is involved. But we're stuck with not being sure.

      And so on. Overall, I'd say that both sides of the abortion debate use extremely weak reasons to justify what is essentially a gut feeling.

      Why the rant? Because it can be a purely ethical debate about stem cells same as abortion can be a purely ethical debate. And just as murky.
         

    9. Re:Religious issue by Archangel+Michael · · Score: 4, Insightful

      Your choice of words "Choice" and "Anti Choice" give insight into who's choice you give deference to. Last time I checked, the babies weren't given a choice.

      And at what time to you "choose" to stop calling it "fetal tissue" and start calling it a "baby" (human, person or otherwise)??

      How come you didn't call it "Pro-Life" and "Pro-death" ?? By simply choosing your words, you've clearly tried to frame the "choice" into something more palatable to your feelings.

      Here's my challenge to you. Stop calling it "Anti-choice" and calling it by "Pro-Life" for a year. The side hasn't changed, only your words, see if your view on the subject changes. I'm not even suggesting you change it from "Pro-Choice" to "Pro-Death" or "Anti-life". Just stop calling it Anti-life and call it Pro-Life for a year.

      You see, I bet you can't or won't be able to do it. And now you'll make excuses and attack me for even making such a suggestion.

      After all, it is always easier to kill someone if you dehumanize them first. Jews are Pigs. Christians are devils. Muslims are evil doers. Blacks are apes. Women are property. Babies are fetal tissue.

      --
      Agent K: A *person* is smart. People are dumb, stupid, panicky animals, and you know it.
    10. Re:Religious issue by cytoman · · Score: 0

      Either you are being intentionally obtuse or you are really confused here. The choice we are talking about is regarding the adult, not the fetus. I hope that you can think from this new perspective and re-align your thoughts.

    11. Re:Religious issue by Eryq · · Score: 1

      "Pro-choice" and "anti-choice" are perfectly neutral and descriptive ... the issue is whether or not you believe a woman should have the right to choose to abort her pregnancy. Personally, I'm pro-choice.

      And we all know you're not, or you wouldn't have accused the OP of being "intellectually dishonest". So don't pretend.

      The dishonest labels would have been "pro/anti-life" or "pro/anti-abortion". Pro-choicers are not "anti-life" (I just value the life of the mother over the life of a cluster of cells), nor are we "pro-abortion" (I want abortions to be as rare as possible -- but I want them to be legal).

      --
      I'm a bloodsucking fiend! Look at my outfit!
    12. Re:Religious issue by Rostin · · Score: 1

      the choice should be with the person who is pregnant...ethics has nothing to do with it.

      Ah. I guess you must be using the word 'should' in a non-ethical way.

    13. Re:Religious issue by Anonymous Coward · · Score: 0

      Life begins at conception. Over 1/3 of all pregnancies end in miscarriage (medically: spontaneous abortion). Do we outlaw miscarriages?

      Viability begins at 22 weeks. Any fetus cannot survive outside of the womb before then. For me, that's the cut off. Once the fetus can survive on it's own, it is it's own person.

      That said I firmly believe that the rights of the woman supersede any supposed rights of the fetus up to birth. Once the baby is outside it's mother's body it has full rights.

      I believe this way because once we start to define a point where the rights of the fetus supersede the rights of the woman then we have opened a huge can of worms. Recently a woman was forcibly detained at a hospital, and put on bed rest by court order. She was denied a second opinion, she was denied the ability to switch hospitals. Her baby died anyway. But because of the sweeping rights the court granted to the hospital this woman was still given a cesarean section - for a dead baby. A decision that will impact any future pregnancies she may have, may affect her future health, and can even affect her ability to get *health insurance*.

      The woman should always maintain the right to self-determination, and self-sovereignty regardless of the state of her uterus. We already have precedent set by courts that you aren't required to give up your own kidney to save the life of your child - even if you are the only donor. There should be no difference in utero.

    14. Re:Religious issue by Anonymous Coward · · Score: 0

      *whoosh*

    15. Re:Religious issue by Attila+Dimedici · · Score: 4, Interesting

      The article also points out that this method could work around the ethical issues surrounding embryonic stem-cell research.

      This is more a religious issue rather than ethical - much like the pro-choice and anti-choice debate. Same people are anti-stem cell as those who are anti-choice.

      Right, the same people who are in favor of killing unborn babies just because people don't want to have a baby, are in favor of killing unborn babies to harvest stem cells to use for medical research (even though all of the evidence points to those cells being of no medical use).

      --
      The truth is that all men having power ought to be mistrusted. James Madison
    16. Re:Religious issue by mhajicek · · Score: 1

      What's an anti-stem cell?

    17. Re:Religious issue by Anonymous Coward · · Score: 0

      They can't. For whatever reason (perhaps something personal in their life with a miscarriage, or an abortion they now regret, whatever it may be) they feel the need to deal with an issue like this emotionally rather than intellectually. They are incapable of doing otherwise at this point, and very few in that situation ever change. Someone I used to work with, who was rather bright in most areas, had the same problem with statistics. He couldn't understand them, no matter how much effort I put forward to prove him wrong, not matter how many times I succeeded, he refused to accept them. I pointed out to a co-worker who was fully confused by this that there was a personal reason for it, and he'd eventually tell me. A few weeks later I found out his mother had been treated for breast cancer and told she had X% chance to have a another occurrence (it's been years and I don't recall exactly what it was). She did everything she could to improve those odds. It didn't help. But refusing to understand a segment of mathematics didn't help him cope with it and grow as an adult, either, it just stunted his intellectual growth.

    18. Re:Religious issue by plenTpak · · Score: 1

      I have to disagree that "pro-choice" and "anti-choice" are perfectly neutral and descriptive. "Pro-choice" focuses on the choice part. "Pro-life" focuses on the life part. Those things are what they stand for. Just as "Pro-choice" doesn't stand for death or abortion, "Pro-life" doesn't stand for anti-choice.

      "Pro-choice" / "Pro-life" may not be perfectly neutral and descriptive, but I would have to say that it's more neutral and descriptive of what they stand for than "Pro-choice" / "Anti-choice".

    19. Re:Religious issue by telomerewhythere · · Score: 1

      "anti-choice"?

      While I will never try to legislate your (or anyone's) actions, I think that the choice is made when a female allows a male entrance. There are caveats, true.

      But, if a religious person/couple opposed to abortion fertilizes many eggs, shouldn't they do their best to bring *all* to term? I think it would be hypocrisy to do otherwise.

    20. Re:Religious issue by Draek · · Score: 1

      No it isn't, please inform yourself before speaking any further.

      --
      No problem is insoluble in all conceivable circumstances.
    21. Re:Religious issue by Anonymous Coward · · Score: 1, Funny

      When an anti-stem cell touches a normal stem cell, they both disappear in a violent burst of energy.

    22. Re:Religious issue by Anonymous Coward · · Score: 0

      Using the code word "anti-choice" reveals your eye-rolling bias.

      Further you say "anti-stem cell" which isn't true at all. Pro-life advocates may be opposed specifically to embryonic stem cell research, particularly involving new lines, because it destroys a potentially matured human life. You paint with such a broad brush, even in the follow up as to bely your bias.

      You love abortion. Tens of millions per year. We get it. You have no ethical hang up about destroying human life whether for science, economic convenience or whim. We get it. Sounds to me like you have some deep issues. Maybe you made a gf get an abortion and have guilt issues?

    23. Re:Religious issue by Anonymous Coward · · Score: 0

      You have ignored the other posters.

      Let me spell their point out for you.

      You believe that they are "anti-choice" and that this is not an ethics issue, because it all comes down to an individuals beliefs in when life starts.
      Since you don't believe it starts at conception, anyone who believes it starts earlier is removing your choice.

      They, by your own admission, do not believe the same thing. They believe that life begins at conception. This means that they do not even believe there is a "choice" at all.

      The analogy would be believing you have the "choice" to kill another person, without their knowledge or consent, in order to benefit science.

      This is unethical. This is what they believe you are doing. Since you do not believe you are killing someone, the choice is there for you and you view them as "anti-choice".

      This is why I hate the term "pro-choice". There is no choice in question for those who are "pro-life", just as there is no life in question for those who are "pro-choice".

      Pro life people do not ignore womens rights, many of them are women. They do not want to remove your freedom, they want to protect the freedom of a person you do not believe exists.

      Please realize that by arguing two different points, both sides fail to get anywhere in the argument.

      I suggest you sincerely try to define where you are willing to "draw the line" in regards to potential murder. I am not trying to use emotional language, but that is what we are doing. We are deciding when, as a society, disposing of something that will eventually become a human being is actually killing a human being. When removing this potential life the equivalent of human murder?

    24. Re:Religious issue by Anonymous Coward · · Score: 0

      I am very much pro-abortion.
      Clearly you haven't driven a car in the last 100 years anywhere, if you would have then you would be pro-abortion to.
      IMMore rolling accidents should be murdered before they start to breathe.

    25. Re:Religious issue by Gorphrim · · Score: 1

      Last time I checked, the babies weren't given a choice.

      You're right, we should let babies make more decisions about their lives...

      --

      Queens of the Stone Age - they rule
    26. Re:Religious issue by fedos · · Score: 1

      Cytoman's point is that the anti-choice position is entirely religious and has nothing to do with ethics.

      Nice going with trying to make it look like he said something that he didn't.

    27. Re:Religious issue by Rostin · · Score: 1

      Well, I have to admit that his point is a little hard for me to grasp, since it forces a false dichotomy between religion and ethics.

      It also ignores purely secular arguments that have been made against abortion.

    28. Re:Religious issue by maxwell+demon · · Score: 1

      Life begins at conception. Over 1/3 of all pregnancies end in miscarriage (medically: spontaneous abortion). Do we outlaw miscarriages?

      Quite many humans die from illnesses. So if you outlaw murder, you also have to outlaw illnesses?

      Viability begins at 22 weeks. Any fetus cannot survive outside of the womb before then. For me, that's the cut off. Once the fetus can survive on it's own, it is it's own person.

      What about people in intensive care? They obviously cannot survive on their own. So is it OK to kill them?
      What if a working artificial womb gets invented and built? Then a fetus could survive outside of the womb much earlier; possibly from day one. But how could the existence or nonexistence of an invention determine if a fetus is its own person?

      That said I firmly believe that the rights of the woman supersede any supposed rights of the fetus up to birth. Once the baby is outside it's mother's body it has full rights.

      OK, so you say that after 22 weeks, the fetus is its own person, but still effectively doesn't have any rights. Doesn't seem very consistent. Why should the rights of someone depend on where he currently is?

      The example you gave is a case where a very important right of the woman was affected: Her health. However the rule as you formulated it would apply to any right. Basically you would allow the mother to kill her baby a few days before birth (and yes, at that time it already and very clearly is a baby) just because she feels like that.

      We definitely need a general rule about when a collection of human of cells is to be considered a human. But all your rules are quite arbitrary, and where you gave arguments, they are quite weak.

      One possibility would be to use the brain as criterion. After all, our personality mostly resides in our brain; so one could say it's the brain which makes us human. It's also consistent with the rule that you're dead when your brain has stopped working. And while there are people with damaged or malfunctioning brains, there are no people without any brain, because you cannot live without it. Since embryos don't have a brain, embryonic stem cells would then be without ethical problems.

      --
      The Tao of math: The numbers you can count are not the real numbers.
    29. Re:Religious issue by Archangel+Michael · · Score: 1

      I must be an idiot for not thinking of that! Gee Whiz. Thank you so much for enlightening me.

      Last time I checked, the babies weren't given a choice.

      Oh wait, I clearly make the point that the only one being presented with a "choice" was the adult. BTW, a baby is not a choice, it is a baby. Calling the baby a choice is simply something people do to ease their conscience when they want to kill it.

      Read my point about dehumanizing people in my previous post. Tell me why you feel comfortable dehumanizing a baby so you can kill it.

      re-align your thoughts

      You have given no reason why I should, other than my opinion is different than yours. But thanks for playing along with me.

      I realize you're not capable of my suggestion.

      --
      Agent K: A *person* is smart. People are dumb, stupid, panicky animals, and you know it.
    30. Re:Religious issue by Anonymous Coward · · Score: 0

      Jews are Pigs. Yep, fat in riches because they band together and encourage education. Something people should be proud of.

        Christians are devils. Yep, most violent religion in history. Lots of people died in the name of "Chirst". I'm Christian, gotta know your own history.

        Muslims are evil doers. In the eyes of most Christians. Islam is a very old respectful religion. Again, history. All of the violence of this religion is no where near Christianity, and by violence I mean small sects of extremists.

      Blacks are apes. Again, go go white Christians.

      Women are property. Seems to be a problem around the world

      Babies are fetal tissue. When they're developing

      "And at what time to you "choose" to stop calling it "fetal tissue" and start calling it a "baby" (human, person or otherwise)??"
      Anything with "human" DNA is "human". My skin is "human", a corpse is "human" and living corpse without a brain is "human" but also known as a vegetable. A person does NOT have to be human. All it has to do is be self-aware. A very young child is not self-aware.

      You call it "Pro-Choice" because you can choose. "Pro-Life" just means you have no choice and the child must be allowed to live.

      Life itself has no intrinsic value, if it does, show me the math. The only value is your own life. Logically, the best way to ensure your own life is to be in a society where people protect eachother's lives. Your offspring carry your own DNA, which is effectively you only way to living past your own death. If you do not wish to have an offspring, that is both your's and the partner's choice. Once that offspring is born, you would want laws/rules in place to help protect your offspring since it helps the survival of your DNA.

      Logically, the only reason to make murder illegal is because helping someone else increases your chance of being helped. Protecting other women's reproductive choices helps protect your own partner's reproductive choice and protecting the life of another person's child helps you protect your child, but protecting the life of an unborn child that even the mother does not want does not help you at all.

      This logic also applies to racism. Let say I was a Nazi and I went along with the exterminations. After the genocide was done, what would there be to stop the law from suddenly saying that Germans with freckles like me need to be exterminated? Protecting the Jews would also indirectly protect myself. People who are racist, once they've accomplished their goal, will find something else wrong/different to be racist about. It's an unstable variable.

      In the end, everyone dies. Live and let live.

      I know what I said was dry and had no emotion, but emotion should NEVER be used for important decisions. Emotion is analogous to flipping a coin to see how you "feel" that this moment. Emotion causes people to kill other people and people to love each other for no reason. It's a random variable. Save emotions for minor decisions. Logic is that thing you use when you're emotionally angry at someone but you keep yourself from decking them in the face.

  22. check out the excessively big brain on Brad by Onymous+Coward · · Score: 3, Interesting

    Don't get carried away and be all rash now.

    Some drugs actually promote neurogenesis. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253627/

    You wouldn't want to get stoned all the time and then have this new cell therapy and end up with too many neurons.

    1. Re:check out the excessively big brain on Brad by zach_the_lizard · · Score: 1

      Antidepressants also induce growth in the hippocampus, IIRC.

      --
      SSC
    2. Re:check out the excessively big brain on Brad by Onymous+Coward · · Score: 1

      Yeah, but be careful with SSRIs, they can be very dangerous.

      (aggravated suicidality, serotonin syndrome, sexual dysfunction...)

    3. Re:check out the excessively big brain on Brad by Bengie · · Score: 1

      I get a HUGE buzz from SSRIs. Kind of scary really. Doctor told me I'm sensitive to serotonin. Took 1/4 of the minimum recommended dosage for people starting and I had a 5 hour adrenaline rush with 120 pulse and I left like running to burn off my energy.

      But it was literally like an adrenaline rush because my body felt VERY light, sometimes I over used my muscles, I would grip things too tightly, few times I hit stuff by accident and felt no pain... crazy reaction, never again.

  23. Re:Fetal Stem Cells Need Not Apply by Gerzel · · Score: 2, Insightful

    For a while probably, at least until adult stem cells are actually proven to be as useful as embryonic stem cells and are able to be used interchangeably. Yes there are some uses of adult stem cells that have produced therapeutic results but not every therapy or study can be done with adult cells.

    Furthermore there is not much of an ethical dilemma for using embryonic stem cells as they are not children nor will they ever develop into children. The problem is political and based in the morality of others which doesn't consider very deeply the question. The problem is that people often equate potential life for life, and this is wrong and ultimately produces evil.

    For instance if you really believed that embryos had the same worth as a fetus or a child and a hospital was burning and you could only rescue all the babies in the maternity ward(we'll say 24 of them) or all of the potential babies in the cryogenic freezer then you logically would rescue the freezer as you would save far more lives. I for one would choose the actual babies and save the maternity ward.

  24. Re:Fetal Stem Cells Need Not Apply by Wyatt+Earp · · Score: 2, Informative

    Nature is only organic if it has carbon in it.

  25. Article by interkin3tic · · Score: 4, Informative

    For those of you trying to find the actual nature article, here. I know we hate paywalls, but it should really be required for submission to slashdot that a link to the real paper, not preview, be included.

    I am not a stem cell biologist, nor am I a neurobiologist, and I will need to read the paper more carefully when I’m at home, but some of my thoughts:
    There do seem to be some hurdles to using this in humans, but many are trivial in comparison, and the reason the authors didn’t do them yet is because they wanted to get this out there before anyone else did. For one thing, they haven’t shown this in humans yet, but it should work in human cells that’s their stated next step. These cells were grown using dead mouse “feeder cells” which is common in cell culture, but complicates things for human therapy. You don’t want even dead mouse cells or other people’s dead cells in something that is going to go into your brain. People are working on culturing without feeder cells, I’m not sure where they are on that. The method of getting the 3 genes in is also an issue. These guys used lentiviral transfection, which is not something you want for human cells. Earlier work on IPSC got it done by incubating cells with transcription factor –protein- modified to penetrate cells. That might be a good next step here, though it would probably decrease the efficiency.

    A bigger issue to me is what they are transfecting. They’re putting in three transcription factors, Ascl1, Brn2 (also called Pou3f2) and Myt1l. One of them, Ascl1, is found in many cancers (according to wiki anyway) and might be tumorgenic. Especially if they find they can’t get it to work without viral transfection, that could be a concern. The other two though aren’t tumorgenic apparently. Brn2 (also called Pou3f2) and Myt1l are both associated with neuron differentiation, which is interesting.

    They did overcome a big hurdle: these are not pluripotent, which probably means there’s less chance of causing tumors, teratomas. With induced pluripotent cells, that is a concern. If you were to inject IpsC into your brain, you don’t know what you’re going to get. You could get bone cells growing in there, cells which aren’t supposed to be there that could potentially cause tumor formation. This doesn’t seem like that will be an issue here, they apparently get all neurons, neurons which appear not to continue dividing. I do find it a little hard to believe though that these only produce neurons and never glial cells, though I’ll need to reread it a few more times.

    This is also a interesting paradigm shift for developmental biologists: apparently you don’t have to go back to square one to switch cell fates, it will take longer and be less efficient to do so. IpsC take about a month to become pluripotent and then be grown back into neurons, and only about 1% of the cells do that if I recall correctly. These take a week.

    For much of the study, they seem to be using 5 different factors, not the 3 minimal ones. They state that Ascl1 alone was sufficient to make these cells start looking like neurons, but the other two were needed for them to look and behave like mature neurons. Most of the figures were working with a combination of 5 factors. With all 5, they showed a good mix of different types of neurons, but that had less efficient conversion than the minimal 3. I’m wondering if you’d actually be able to get all the different types of mature neurons with just the 3. I’d guess it’s not that they intentionally did it that way, but they wanted to hurry up and publish ASAP, so they skipped doing that characterization for now.

    One problem facing all these therapies eventually, as I understand it, is that you want to get one specific type of neuron for therapy. I have no idea what strategies there are to direct differentiation into specific types of neurons, but this seems like it would be the bigger hurdle.

  26. Using skin cells as a base ingredient by gringer · · Score: 1

    I'm not particularly keen on the idea of using skin cells for this. Sure, they're readily accessible (not very invasive), but skin cells are really close to the surface of the body (or at the surface of the body), and therefore really close to environmental influences. They die frequently (a fair amount of the dust in your house is dead skin cells), and are exposed to many things that can cause genetic mutations, sunlight probably being the biggest thing. If I had to regenerate neurons from other body cells, I'd rather something that was a bit more internal and reasonably far away from damaging sources (liver, for example).

    --
    Ask me about repetitive DNA
    1. Re:Using skin cells as a base ingredient by ChrisMaple · · Score: 3, Funny

      So you want to take your body cells from where the sun doesn't shine.

      --
      Contribute to civilization: ari.aynrand.org/donate
    2. Re:Using skin cells as a base ingredient by Arthur+Grumbine · · Score: 1

      ...and reasonably far away from damaging sources (liver, for example).

      Yeah, but it doesn't help much when we bring those damaging sources to them.

      --
      Now that I think about it, I'm pretty sure everything I just said is completely wrong.
    3. Re:Using skin cells as a base ingredient by maxwell+demon · · Score: 1

      Well, I'd suggest using neurons. As added bonus, turning them into neurons is trivial: Just apply the identity transformation. :-)

      --
      The Tao of math: The numbers you can count are not the real numbers.
  27. Re:Fetal Stem Cells Need Not Apply by Anonymous Coward · · Score: 0

    ah the silicon based organisms in the audience speak up

  28. Is anyone worried about this virus escaping?... by Anonymous Coward · · Score: 0

    Is anyone worried about this virus escaping? We could all end up as a big blog of brain cells sitting on the floor! :D

    1. Re:Is anyone worried about this virus escaping?... by maxwell+demon · · Score: 1

      But think of the brain power you would then have!

      --
      The Tao of math: The numbers you can count are not the real numbers.
  29. I don't know if I'd go as far as that quote by NotSoHeavyD3 · · Score: 2, Informative

    I mean the "This suggests that there are no great rules -- you can reprogramme anything into anything else." quote. From what I remember from bio class tissues in mammals split into 3 different layers early on, the ectodermm the mesoderm and the endoderm. Oddly enough both skin and nerves come from the ectoderm. So what the scientist has demonstrated is he can turn on part of the ectoderm into another. (Not that he could say take endoderm from say the intestines and convert it into skin.)

    --
    Did you know 80 to 90% of the moderators on slashdot wouldn't recognize a troll even if one dragged them under a bridge.
  30. Cell Base + 3-D cell = Immortality!!! by jameskojiro · · Score: 1

    Just print yourself up a new body and replace the brain one hemisphere at a time and you too can live forever!!!!

    No guarantees if you can preserve you "ghost"..... or not....

    --
    Tsukasa: All I really want, is to be left alone...
  31. First Time Eh? by Favonius+Cornelius · · Score: 1

    Not the first time, but the first announced. :}

    --
    "Men willingly believe what they wish." - Julius Caesar
  32. Re:Fetal Stem Cells Need Not Apply by 0100010001010011 · · Score: 4, Insightful

    We also owe a very very large portion of our current medical knowledge to the Nazis. If it wasn't for their 'human experiments' we wouldn't know some of the stuff we know today.

    Where do you think we got the 'how long you can survive without food/water' stats?

    Doesn't mean it was right.

  33. You support ageism? Or hate the mentally ill? by Anonymous Coward · · Score: 0

    > The choice we are talking about is regarding the adult, not the fetus.

    If the fetus isn't human, what species is it? By what right do you deny them a choice?

    And if you're going to tell me that reasoning is "speciesist," please explain why killing a fly for annoying you isn't speciesist, because the only reason people do it is because they regard flies as less valuable than human beings. No one would regard someone as anything but a murderer if they killed a person for the reasons they might kill a fly.

  34. Re:Fetal Stem Cells Need Not Apply by Anonymous Coward · · Score: 0

    If someone punched your wife (or you, depending on your gender) in the groin three to 4 weeks after conception and cause a miscarriage, what would you want them charged with?

  35. Wearable computer! by Baldrson · · Score: 1

    So the obvious next step is to create neurons in situ for a wearable biocomputer powered by your body! Yes the world of the future is a bit like having bees live in your head but, there they are, and like the lady said "I said live it, or live with it!"

  36. No need for stem-cell work-around by Meshuggah24 · · Score: 2, Insightful

    There is no need for a work-around on Stem-cell research. Stem-cells are taken from already dead fetuses. There is no ethical issue. Why do people have so many damn problems with using dead tissue to save lives? Either way the technical feat achieved here is still remarkable. It is a work-around not from an ethical perspective but getting the same results from a more abundant cell.

  37. Re:Fetal Stem Cells Need Not Apply by interkin3tic · · Score: 2, Insightful

    If you never do research with fetal stem cells, you'll never know what they can do.

    To add to that, you know what research started us down this whole avenue, right? There are quite a few genes in the genome, but they only looked at 19

    Reasoning that multiple transcription factors would probably be required to reprogram fibroblasts to a neuronal fate, we cloned a total of 19 genes that are specifically expressed in neural tissues, have important roles in neural development, or have been implicated in epigenetic reprogramming

    How did they come up with that magic 19 instead of like 100,000 in the mouse genome? Other studies that used fetal stem cells, or possibly IPsC cell studies, which themselves were discovered based on knowledge gleaned from studies in fetal stem cells.

    If there had been no research on fetal stem cells we wouldn't have this, induced pluripotent stem cells, OR much knowledge about adult stem cells (which, not for nothing, haven't gotten us to the finish line yet, which is -why- research continues) and very little hope for anyone who has medical conditions like paralysis or parkinson's disease.

    Instead we would have a little more incinerated biomedical waste from fertilization clinics.

    Yeah, we really made the wrong decision there.

  38. Re:Fetal Stem Cells Need Not Apply by Anonymous Coward · · Score: 0

    I am here. Your robotic overlord. You may have heard of my name...Lord Vibrator.

    All your vagina are belong to us.

  39. Re:Fetal Stem Cells Need Not Apply by telomerewhythere · · Score: 1

    if you really believed that embryos had the same worth as a fetus or a child and a hospital was burning and you could only rescue all the babies in the maternity ward(we'll say 24 of them) or all of the potential babies in the cryogenic freezer then you logically would rescue the freezer as you would save far more lives. I for one would choose the actual babies and save the maternity ward.

    False Dichotomy

    Or put another way, same proposition, only one choice, a baby or an old grandmother. Which would you save?

    Or your old grandma or an unknown baby? which? Or your baby and and unknown granny? which?

  40. Re:Fetal Stem Cells Need Not Apply by Draek · · Score: 1

    For instance if you really believed that embryos had the same worth as a fetus or a child and a hospital was burning and you could only rescue all the babies in the maternity ward(we'll say 24 of them) or all of the potential babies in the cryogenic freezer then you logically would rescue the freezer as you would save far more lives. I for one would choose the actual babies and save the maternity ward.

    You would. Others wouldn't, and would see you as evil for making that choice.

    "Ethics" != "my own morality". Learn and understand that.

    --
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  41. Re:Fetal Stem Cells Need Not Apply by the+biologist · · Score: 1

    Which medical advances are you referring to?

    Ones which come to mind:
    Tolerance limit of humans to extreme cold.
    Tolerance limit of humans to extreme sound intensity.
    How to dispose of large quantities of human bodies.

    In the first two examples we didn't need testing to destruction to know the relevant limits.
    The third example was included as something of a jest, as it really was more of an engineering problem.
    In any case, not exactly a "very very large portion" of current medical knowledge.

  42. Re:Fetal Stem Cells Need Not Apply by the+biologist · · Score: 1

    oh, sorry. I didn't address your example.

    "How long can you survive without food/water"?
    We've had lots of data from people getting lost in the wilderness, from well before the Nazi's.

    Why did the Nazi doctors think it was worth testing on human subjects?
    1. Their primary purpose was to kill prisoners.
    2. They were sadistic fucks.
    3. The previous information was not the result of controlled experiments.

  43. Re:Fetal Stem Cells Need Not Apply by 0100010001010011 · · Score: 1

    http://en.wikipedia.org/wiki/Nazi_human_experimentation

    Experiments on twins
    Freezing experiments
    Malaria experiments
    Mustard gas experiments
    Sulfonamide experiments
    Sea water experiments
    Sterilization experiments
    Experiments with poison
    Incendiary bomb experiments
    High altitude experiments

  44. Re:Fetal Stem Cells Need Not Apply by Gerzel · · Score: 1

    Baby, greater potential and actualization.

    It isn't a dichotomy it is more of a trichotomy. There is value in actualization, and greater potential in a baby or fetus that is many months developed than a frozen embryo.

    For one there are not enough whombs in the world to carry all the frozen embryos. Secondly many embryos never develop into babies and many babies don't develop into adults.

    The grandmother has presumably lived a long time and has had a chance to procreate and see her children procreate, where-as the child has only lived a short time but has great potential and developed far beyond the embryonic stage.

    Also both my grandmothers are already with the Lord and I have no need of their corpses. Even if alive I'm sure they would have me make the same choice as they would have more chance of escaping the fire on their own where-as a baby would not.

  45. Re:Fetal Stem Cells Need Not Apply by Gerzel · · Score: 1

    Assault. Three to four weeks isn't very long in development. And while assault on a visibly pregnant woman should carry a stiffer penalty for endangering the life of the unborn child, the development of that child must also be taken into account.

  46. Re:Fetal Stem Cells Need Not Apply by Gerzel · · Score: 1

    Ethics are however equal to a standard of action that is well thought out and thus can be argued and debated between individuals.

  47. Re:Fetal Stem Cells Need Not Apply by gd2shoe · · Score: 1

    You ignore the most frequent cause of abortion: panic. (combined with the inability to take responsibility)

    In many cases, aborted fetuses wouldn't survive to term anyway...

    Very few of the abortions performed are specifically because the child will not make it. However, abortions related to the chance of abnormality (such as autism) will climb as it becomes increasingly feasible.

    or are a threat to the mother's health...

    Rare, but real. (I've heard people claim that this never happens, but that's not true. It's just unusual.)

    It's cost us years, possibly as much as a decade, of research time because of religious considerations.

    It's not just moral (religious) reasons, but also ethical ones.

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  48. Re:Fetal Stem Cells Need Not Apply by gd2shoe · · Score: 1

    Besides, hES don't come from aborted fetuses, but from in vitro fertilized embryos that never get implanted. (similar moral/ethical issues but very different legal debates)

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  49. Re:Fetal Stem Cells Need Not Apply by Artifakt · · Score: 1

    That makes a certain amount of logical sense. The way you have phrased it, it also sounds like common sense, which may or may not actually matter - good rhetoric does not always make a good argument.
          But logical and scientific principles are not exactly the same things here.
          There's a number of reasons within the scientific method for thinking that stem cell research on fetal sources would give society valuable tools for fighting various diseases - but those reasons rise only to hypothetical status - that is they individually deserve to be called hypothetical, but don't have nearly enough supporting facts to deserve to be called theoretical. Part of the problem here is that the pro-fetal stem cell research side has talked about it as though there's strong, well established theoretical underpinnings for it producing really significant results of tremendous value to society, which we can't get from other sources such as umbilical cord tissues or adult stem cells. There have been too many claims that fetal research will eventually cure all cancers and other methods simply won't, or will, at the very least, take many times as long to get the same results.
          To make such claims justifiably, we would have to know a lot of things we just surmise, such as that certain hypothetical models of the effects of lengthened telomere accumulation were better than other models, all coming from established scientists with solid reputations.
          There's probably some real negative costs to society in being asked to decide whose science is better, ahead of normal processes of peer review and reproducing experiments or devising the new ones needed to settle which models have better predictive power.

    --
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  50. Possible bad uses of this? by Anonymous Coward · · Score: 0

    From the article:

    A further question is why, if cells retain an underlying versatility, they don’t switch between cell types throughout our life

    No answer to that. Freaky. Try to figure all nasty corners such technologies could bring the mankind to.

    When will living people's skin cells start turning into neurons then?

  51. Re:Fetal Stem Cells Need Not Apply by Anonymous Coward · · Score: 0

    This is a straw man since we do not know how many of the embryos in cryogenic freeze will survive after implantation.

    These are not the same question.

    The question would be do you save 12 babies or 24 magical embryos in jars that are guaranteed to become adults in 9 months.

    In any case, you are also incorrect in saying that equating potential life with life is evil. What does this even mean?

    They are not equating anything, they merely draw the imaginary line earlier than you.

    To follow with a bad analogy, say you are on price is right, but you are the only contestant. What do you bid?

    If you answer anything but 1, you are being illogical. You may not be close to the right price, but you will be sure to win the prize if you bid under the correct price.

    Now imagine that instead of bidding on a car, you are bidding on a box that may contain a man. You are not sure if it does. If you overbid, the man dies. You spend up to nine months jail if you underbid. What do you bid?

    It now becomes a risk assessment involving the following factors:

    What is probability that there is a man in the box?
    How much do you value the life of a stranger?
    How much do you value your own freedom?

    It is not an easy task to come up with a number, but you must admit that if the mans life is the most important thing, even if you are not sure that he is there, you will still bid one dollar, and risk spending a good deal of your time in jail.

    If you do not believe the man is there, for whatever reason, you may bid a very high number indeed, because you don't want to risk jail time.

    The real question is, what information are you basing you assumption on? Why do you believe, or not believe, in the man in the box?

  52. Re:Fetal Stem Cells Need Not Apply by Hatta · · Score: 1

    Really? A very very large portion? How many people are alive today because of knowledge gained from nazi medical experiments? You are engaging in hyperbole.

    Besides, the situation is completely different. Even if you assume that the subjects of nazi experiments were going to die anyway, the experiments caused excess suffering. Stem cell research causes no suffering.

    If we ripped fetuses out of women for the sole purpose of doing experiments on them, then you would have some cause to compare it to the nazis. This however is pure trolling.

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  53. Re:Fetal Stem Cells Need Not Apply by MobyDisk · · Score: 1

    Where do you think we got the 'how long you can survive without food/water' stats?

    Haiti.

  54. Cold Fusion? by Anonymous Coward · · Score: 0

    Oh, neurons are different than neutrons?

  55. Re:Fetal Stem Cells Need Not Apply by Gerzel · · Score: 1

    It is not a straw man as I am arguing that the actualized baby life is worth more than the sum of all the potential life in the embryo freezer. Also while many do die a freezer could easily hold more than enough embryos to have a very good chance of forming 24 babies if carried by a healthy mother.

  56. Re:Fetal Stem Cells Need Not Apply by Danse · · Score: 1

    You ignore the most frequent cause of abortion: panic. (combined with the inability to take responsibility)

    Not sure that's a defensible claim there. Why not say that the most frequent cause is the desire to not have a child because they're not ready or are unable to properly support one, or any of a bunch of other reasons? What evidence is there that panic is the most common cause? You know, aside from made for TV movies on Lifetime...

    --
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  57. Re:Fetal Stem Cells Need Not Apply by gd2shoe · · Score: 1

    the desire to not have a child because they're not ready or are unable to properly support one, or any of a bunch of other reasons

    ==> "the inability to take responsibility"

    You're argument isn't inaccurate in any way, just disingenuous.

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  58. Re:Fetal Stem Cells Need Not Apply by Danse · · Score: 1

    Your phrasing makes it sound as if it's a foregone conclusion that having a child is always the best option though, and only a deficiency in the parents is responsible for their choice to have an abortion.

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    It's not enough to bash in heads, you've got to bash in minds. - Captain Hammer
  59. Re:Fetal Stem Cells Need Not Apply by gd2shoe · · Score: 1

    I can see why you might think that. "Always" is too strong. "Almost always" is closer to reality.

    In turn, your phrasing makes it sound like abortion is a valid option in the general case, and any deficiency in the parents is a valid excuse to destroy the fetal tissue.

    The only supportable "pro-choice" position I see is to defend a woman's right to choose when to have sex. If she does, she has made her choice. Sex organs are not fun organs, they're reproductive organs. You use them when you want to reproduce. I understand the strong pull, but if you don't resist it, you're responsible for the outcome. It really is that simple in the general case.

    I've heard people argue that fetal tissue is not alive, or is part of the mother. That's an outright lie to defend an indefensible position. The real question is: when do human rights begin? At birth, or before? From a religious standpoint it's obvious. From an ethical one, some people think this line is still fuzzy.

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  60. Re:Fetal Stem Cells Need Not Apply by Danse · · Score: 1

    The only supportable "pro-choice" position I see is to defend a woman's right to choose when to have sex. If she does, she has made her choice. Sex organs are not fun organs, they're reproductive organs.

    I recognize that this position of "sex is for reproduction" is held by some groups. I find it to be rather shallow and naive. There is more to sex than simply fun and reproduction too. Even if it is done just for fun, I don't see that that is a commitment to bear or raise a child. I think the whole "life begins at conception" line of thinking to be ridiculously oversimplified. Ultimately our bodies are our own and we should have the right to make these decisions for ourselves. I definitely fall on the pro-choice side, but I would be willing to accept some limit on late-term (assuming that it is defined in a way I consider reasonable) abortions as long as exceptions are made for the health of the mother. Whether this would make any real impact, I don't know, but that's as far as I'd be willing to compromise.

    --
    It's not enough to bash in heads, you've got to bash in minds. - Captain Hammer
  61. Re:Fetal Stem Cells Need Not Apply by gd2shoe · · Score: 1

    I feel that our conversation has only been superficial. As such I understand why it may seem "shallow". You may also want to consider that I, in turn, see your position as naive. (fair is fair)

    Even if it is done just for fun, I don't see that that is a commitment to bear or raise a child.

    Your biology disagrees. It is almost as if you wish there were a second condition to getting pregnant, and abortion is getting shoe-horned to serve your fantasy. It's as if you're saying that you only really get pregnant if you have sex and choose not to abort.

    Ultimately our bodies are our own and we should have the right to make these decisions for ourselves

    It's ironic that I feel this way too. The problem is, I feel this way about the unborn as well as the adult. Quite unlike child abuse or neglect, though, the state cannot defend human rights by stepping in and separating an abusive parent from child* until after birth. That is the crux of the whole dilemma.

    (*always a tragedy, but sometimes a necessity.)

    Rights lead to choices. Choices lead to consequences. Consequences give us the chance to be responsible or irresponsible.

    Of the things that we do have rights to, we can't always pick the consequences. I can say that I have a right to skydive without a parachute. The consequence for that is well known and fixed. Yes, I can come up with all kinds of bad examples, but it get's the point across. Every action has one or more consequences. You choose those based on your actions, not your wishes. That's life.

    ...as long as exceptions are made for the health of the mother...

    Here, at least, is a point we can agree on. There should be accountability for these decisions, but medical need should not be withheld, even if that means choosing the life of the mother over the life of the child. I believe that in such situations it is reasonable and healthy to mourn such a loss.

    I think the whole "life begins at conception" line of thinking to be ridiculously oversimplified.

    Ok, if it's oversimplified, then why don't you elaborate. When do you believe life starts (and human rights) and why? Defend your position. Give me an argument that I can respect, even if I disagree with it.

    There are many different aspects to this topic. Religious (which I am setting aside for the time being), ethical, biological, psychological, social, legal, historic, philosophical -- the list just goes on and on...

    The only thing I've heard from you so far is that you think (meaning feel or wish) that society should be one way. You're frustrated that there are people that feel differently, but you haven't promoted a rational with which you can express yourself. I'm just waiting to see what you're underlying beliefs are. What brought you to your conclusions?

    (If you care to share. If you don't, that's fine too.)

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  62. Re:Fetal Stem Cells Need Not Apply by Bengie · · Score: 1

    In one of my college classes, my teacher sparked an interesting debate on abortion. It turned into a 2 day discussion, it was quite interesting. But the most interesting part was how the teacher ended the discussion.

    He showed average crime rate per state and showed when abortion was legalized. Seemed after the same amount of years after abortion was legalized, each state showed a minor decline in crime. It was consistent across every state and every state legalized abortion at a different time. They could not say as to why this happened, but they figured reducing the amount of "unwanted" children or children born to families that could not support the child was the most probable cause.

    But really, a fetus is by all definitions, parasitic. Heck, it even releases a chemical that is IDENTICAL to another human host parasite.

    Personally, I believe the best fix is better education and people who learn to control themselves better.

    Since one person's rights may no take over another person's rights, what happens when a woman decides she wants to get wasted and sit in a hot tub? What if she feels like wrestling? What if she feels like UFC? No one may stop her, but sucks to be leeching off of someone and they decide to do something that may negatively affect the leecher.

  63. Re:Fetal Stem Cells Need Not Apply by gd2shoe · · Score: 1

    Interesting. Anecdotal, but interesting.

    Did he say what type of crime was down? That could make a major difference. (I assume the number of illegal abortions dropped when abortions were legalized, but what else? Child neglect? Violent crime, incl spouse abuse? Drug crime? Petty theft? There's just not enough here to come to any conclusions.)

    But really, a fetus is by all definitions, parasitic. Heck, it even releases a chemical that is IDENTICAL to another human host parasite.

    I think you have that backwards. There exists a parasite that releases a chemical identical to a fetus (or more likely, the placenta). Superficially, it sounds like the Endocrine System functioning properly.

    Personally, I believe the best fix is better education and people who learn to control themselves better.

    Same here. Unfortunately, there will always be people who don't (even if lectured-- um, "educated"). Hence, this issue will still be a legal debate for a long time.

    You bring up a good point that abortion isn't the only issue at play here (it's the one that's most widely discussed). (By the way, you missed teratogens such as alcohol and tobacco.) I guess the biggest difference is that the later is negligent, and the former is willful. I'm not sure just where to stand legally on the larger issue. That is a real conundrum.

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  64. Re:Fetal Stem Cells Need Not Apply by VeNoM0619 · · Score: 1

    Unit 731 Which was Japan, apparently conducted the starvation experiments. Apparently Germany and Japan were equally doing terrible experiments during the war.

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