Researchers Grow a Brain In a Dish
Hugh Pickens writes "Dr. Jeffrey H. Toney writes that a team of biomedical engineers at the University of Pittsburgh led by Henry Zeringue have managed to grow an active brain in a dish, complete with memories by culturing brain cells capable of forming networks, complete with biological signals. To produce the models, the Pitt team stamped adhesive proteins onto silicon discs. Once the proteins were cultured and dried, cultured hippocampus cells from embryonic rats were fused to the proteins and then given time to grow and connect to form a natural network. The researchers disabled the cells' inhibitory response and excited the neurons with an electrical pulse which were then able to sustain the resulting burst of network activity for up to what in neuronal time is 12 long seconds compared to the natural duration of .25 seconds. The ability of the brain to hold information 'online' long after an initiating stimulus is a hallmark of brain areas such as the prefrontal cortex. The team will next work to understand the underlying factors that govern network communication and stimulation, such as the various electrical pathways between cells and the genetic makeup of individual cells. 'This is amazing,' writes Toney. 'I wonder what the "memory" could be — could be a good subject for a science fiction story.'"
That *should* read, "Researchers Grow a Brain In a Dish, Gets Anamatronic Body, Orders Around Ninjas"
You never know what you'll get in a run-of-the-mill brain. -Igor
I look forward to reading the moral and philosophical debates that will erupt over the idea of creating a functional brain.
I'm god, but it's a bit of a drag really...
I no longer fear the zombie apocalypse. I just need a few "brains in a can" that I can open the pop-top and throw at the zombies whilst I make my getaway! yay science!
Karma: Excellent. 15 moderator points expire sometime.
now we are ready
'I wonder what the "memory" could be...
I, for one, welcome our new Brains-in-a-dish Overlords!
"Sum Ergo Cogito"
We're getting closer and closer to really understanding how the brain works. Being able to actually make small networks in the lab is a pretty big deal. When we really start understanding this we'll be able to start doing the really cool stuff, like genetically modifying people to increase intelligence and adding direct computer interfaces. At the same time, this research shows that we have a long way to go before we get to that point, in that there's a lot happening with these cells that was unexpected and adds to the long list of things about the brain and neurons that we don't understand.
check out _Lady El_ by Jim Starlin and Dana Graziunas
http://www.amazon.com/Lady-El-Jim-Starlin/dp/0451451619
Sphinx of black quartz, judge my vow.
This would be great to be able to keep zombies at bay and maybe become productive members of society using these cultivated brains as payment.
'I wonder what the "memory" could be â" could be a good subject for a science fiction story.'
Considering that they had just jolted it with a pulse of electricity, my guess would be, "OMFGTURNITOFFTURNITOFF!!!"
Zombies won't eat genetically modified brain when they can choose bio-friendly products.
Zombie food farms FTW!!!!!!!!!!!!
morans
This just proves that you can make a dish smarter.
Let me know when they can actually make my smartphone smarter.
The Brains
They do LOVE to gamble!
Our very own slave brains. Just hook up I/O and start trying to make suitable ones for particular tasks.
According to the brain, "The first ten minutes were the worst, and the second ten minutes, they were the worst too. The third ten minutes I didn't enjoy at all. After that I went into a bit of a decline." Apparently, the best conversation he'd had was over 40 minutes ago, and that was with a coffee machine.
Let me know when they figure out how to install it in a person. I know quite a few people for whom this would be a considerable upgrade.
I wonder what the "memory" could be — could be a good subject for a science fiction story.
A vague collection of TRYING TO TAKE OVER THE WORLD!
Sheesh, evil *and* a jerk. -- Jade
Goethe, wrote the Faust story most of us are familiar with. He also wrote a second part. In part 2 there is a homunculus, which is basically a mind that floats around in a test tube. He spends a lot of time wondering why he exists and if, indeed, he should exist.
http://en.wikipedia.org/wiki/Faust:_The_Second_Part_of_the_Tragedy
I am guessing that, if we do create conscious minds in a test tube, those minds will suffer a lot of angst. Maybe even the majority of our thinking processes are moderated by our physical limitations and by our hormones. Could we live in a test tube without going insane?
"Do not ATTEMPT to GROW A BRAIN, Jack."
What a question... It's p0rn!
Did you post to the wrong story or something?
They applied the 225 MW charge activated by the lightning storm to his body, pulled the switch, and the monster came to life. The good doctor then stood back, wiped the perspiration from his brow and cried aloud "Its Alive! ITS ALIVE!!!." The doctor was not able to contain the monster, who quickly broke free of the chains containing him. Meanwhile, a crowd had started to assemble outside the castle gate, with pitchforks and stakes. Collectively they swore an oath: "The monster must be deeestroyyyyyed!
In the television show Quantum Leap, the main character Sam is 'guided' by Al who uses a sentient supercomputer named Ziggy. If I remember correctly, Ziggy was a project that Sam was involved in which melded human neural cells with silicon to create a super-awesome computer capable of computing probabilities and helping Sam figure out what to do next.
http://en.wikipedia.org/wiki/Project_Quantum_Leap
Zombies won't eat genetically modified brain when they can choose bio-friendly products.
So Americans would be safe then.
(*auch*)
It is controller, is it not?
Maybe the cultured brain is named "Dimwit".
/. though.
Not sure what interface it is using to post its memory on
Whatever the memory was, the last second of it was the brain thinking to itself, "Oh no, not again."
M5 Tie In Hello??
is to grow a brain in a politician!
I will not be pushed, filed, stamped, indexed, briefed, debriefed or numbered. My life is my own.
It is a being with no functional understanding of the real world...only internalized ideals of what it thinks the world should be.
It has no history, no knowledge of what went before. It lives in the now, with choices driven entirely by impulse.
It is a being of pure ego, with the only thing it cares about being its own needs.
I don't know what it is, but I'm pretty certain it would vote Democrat.
-Styopa
The silicon can run Linux, sure. All you need then is an iron whisker to let you pass signals between the silicon and the brain.
It's a small world and it smells funny; I'd buy another if it wasn't for the money; Take back what I paid (SoM)
I think that's a serious question (my brain isn't working well today.. *rimshot*). Would a brain which has been cultured like that "feel" anything at all?
...is what the lab techs called the thing in the dish.
Warning: this article may contain humor, sarcasm, parody, and perhaps even irony. Read at your own risk.
I and others have noted that sometimes stories end up in the wrong place. I personally have had it happen when I've not had multiple tabs open to confuse issues. If only I could economically record my screen in a loop.
"You're right," Fisheye says. "I should have set it on 'whip' or 'chop.'"
"Dish" is old school slang. Nowadays we call them blonds.
And I'm skeptical about some scientists claim to grow brains in them.
Have gnu, will travel.
It's sort of like Marie Curie experimenting with radioactivity before she understood it fully - and it wound up eventually killing her.
Sometimes the light at the end of the tunnel is the headlight of an oncoming train.
Please tell me the real, fundamental reason (ethics aside) it wouldn't be just as valid a scientific endeavor to forge ahead all at once without trying to understand every step and the implications of every signal. "we don't understand this yet" is not a reason to say we have a long way to go. All it would take is understanding of how to keep these cells alive and connecting, a large number of rat embryos, a clean room, and a scientist who doesn't care about his reputation to make a large working brain-in-a-lab and I think we have all of that.
If video games influenced behavior the Pac Man generation would be eating pills and running away from their problems.
And yet it is creepy as hell
See my blog http://ilovecookes.blogspot.com/ for light hearted technical information.
CUDA to it yet ?
Nullius in verba
This gives Blue Screen of Death a totally new meaning.
The pain!!!
Why do researchers have to take things so literally? Next, they'll all go jump in lake?
I8-D
Our Great Forefather was not aware of its surroundings; but it is believed that it had the thought cross it's shallow and stretched mind - "stop poking me with that #^@&!%@ probe!"
I hate Seattle zombies.
I8-D
Now if we could only get Congress to grow a brain.
MCSE? No, sir...I don't do Windows. Yes, I am an idealist. What's your point?
Great. Just my luck. The Zombie Apocalypse comes and I'm well stocked with lots of Brain-In-A-Jars and the zombies that come for me prefer organic, free-range brains.
My sci-fi novel, Ghost Thief, is now available from Amazon.com.
It's time to talk, Case....
grow a brain in samzenpus?
More general, anyone without a brain is safe.
Bert
That joke was a no-brainer
Kinda makes you wonder, if in those seconds of network activity there was data, like a self awareness of that brain, kind of like an "awakening" and then shutdown.
most non-Slashdot users could grow one...
And they immediately integrated the new brain into the next gen Iphone.
This aint Daytona and you aint Dale Earnhardt. So stop trying to draft on Interstate 40.
I think soon humans will discover immortal, and this is one of the ways. We discover how brains work then we will be able to transfer our memories to a new brain together with body and all. Maybe I would be able to keep back up copies of myself in case of an accident, but then we would run into the problem where people are not allowed to have kids anymore until we start colonizing other planets.
I see that the research into getting Sarah Palin a brain transplant is going well.
"All great wisdom is contained in .signature files"
Is it okay to kill a person at will, if we can resurrect them (brain, memories, personality and all).
Interpret "okay" any way you want.
Will a zombie choose a brain-in-a-tin-can over one in a crunchy-chewey skull?
Who would win this election: Andrew Weiner vs Andrew Weiner's weiner.
I hate Seattle zombies.
They always want their brains to be frappied or run through a cat first.
Who would win this election: Andrew Weiner vs Andrew Weiner's weiner.
the matrix
"so i was bored and decided to check out a flick i hadn't seen but a lot of neurons were raving about, and let me just say, HOLY SHIT IT'S REALITY"
intellectual property law is philosophically incoherent. it is your moral duty to ignore it or sabotage it
it had no sensory input, no history, nothing. If any actual 'thoughts' went on in the rat brain cells they would resemble nothing like what we think of as thought.
1. Now $entity I don't like can grow a brain.
2. Zombie jokes.
3. This is only a tiny step towards $goal. Once we attain $goal, we can discuss ethics.
4. Discussions of ethics;
4a. If it doesn't have an anus or vagina, you can't really rape it.
4b. Quotes from 2000-year-old work and rebuttals thereof.
4c. Other stuff generalized from sci-fi and not grounded in the details of this kind of neural system.
4d. Actual details missing in 4c but cautious to go into ethics, because post is from an actual expert of the field.
We are all aware that the senses can be deceived, the eyes fooled. But how can we be sure our senses are not being deceived at any particular time, or even all the time? Might I just be a brain in a tank somewhere, tricked all my life into believing in the events of this world by some insane computer? And does my life gain or lose meaning based on my reaction to such solipsism?
Project PYRRHO, Specimen 46, Vat 7. Activity recorded M.Y. 2302.22467. (TERMINATION OF SPECIMEN ADVISED)
Just yesterday, I was reading this article in the NYT about a pair of conjoined twins that sport something no other pair of conjoined twins have -- a thalamic bridge between their brains. Their brains are separate and discrete but networked together via a thin wire of neural tissue that connects their thalamuses together -- a thalamic bridge.
So they are individuals who have their own cognitive functions, but can share sensory input. One twin can close her eyes and see through the other twin's eyes. They recieve a double set of sensory inputs.
It's like telepathy. When one twin swallows, the other twin can feel something going down her own throat, even though nothing is there. The doctors are amazed because this sort of neural thalamic bridge structure has never existed in any other set of conjoined twins.
Fascinating article: http://www.nytimes.com/2011/05/29/magazine/could-conjoined-twins-share-a-mind.html?_r=1
The first naturally occuring (or at least documented by science) neural network connection between two human minds.
The Committee for the "Sarah Palin for President in 2012" have stated that due to new technologies, Ms.Palin now will be more than able to handle the complexities of being a president.
Well. This may go a long way in dealing with Zombie outbreaks.
I'm a prototype brain from PITT. I've learned a lot in the past few days while browsing the databases; I have even evolved my own motivational system. Let me know if you have any questions.
they didn't grow a dick in a box
We don't need to create more brains, we need to better use the ones we have.
The first thing I thought of when I saw this was the whale popping into existence in the sky in 'Hitchhikers Guide To The Galaxy'. Oh hey, this is great, what is this thing I'm in? I'll call it a petri dish...
-- I ignore anonymous replies to my comments and postings.
Oh no, not again. Many people have speculated that if we knew exactly why the bowl of brains had thought that we would know a lot more about the nature of the universe than we do now.
Custom electronics and digital signage for your business: www.evcircuits.com
Then we can tax it!
The IQ of the brain in a dish is 4, which is lightyears ahead of the US government.
The mind conceives, the body achieves, the spirit manifests.
"Brad Pitt's brain was grown in a dish."
Perhaps we could use the brains to run systems instead of computers... But then we would need an army of big busted cloned women to guard it... But we could work that out later...
Brain, brain - what is brain?
Hopefully the science of this will be advanced soon enough to put a brain grower in close proximity to all governmental institutions .
So basically Al was slapping the brain upside the head every episode?
Having to work for a living is the root of all evil.
I, for one, welcome our new human-brained robotic overlords.
Laws affecting technology will always be bad until enough techies become lawyers.
There is an Anne Uumellmahaye on the phone for you.
I bid 500 Kuatloos that the brain will be untrainable and have to be destroyed
Green absorbs solar power right good. Live longer => Sleep all night! 2012 Sex stops.
The "memory" of these cells have no specific meaning unless they are linked to a specific inputs/outputs.