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Researchers Create First Genetically Modified Monkeys

Several readers tipped news that U.S. scientists have created 'chimeric' monkeys, made with genetic material from as many as six different genomes (abstract). This is significant because it's the first time researchers have used the technique on a primate. From the article: "Researchers took very early stem cells, called totipotent stem cells, from separate developing embryos and basically glued them together, implanting the mixed embryos into surrogate mother monkeys. The cells — from totally different sources — didn’t fuse, but worked together in harmony, forming fully fledged, normal, healthy animals. ... The key here was the scientists’ use of totipotent cells, so named for their ability to differentiate into the totality of possible cells in an animal. A totipotent cell can give rise to a whole animal. Pluripotent stem cells, the type most frequently used in stem cell research, can differentiate into any cell in the body, but can’t become a whole animal, and can’t make other embryonic tissues like a placenta. Totipotent stem cells are only derived from the very earliest stages of a zygote, mere days after fertilization. In humans, totipotent cells differentiate into pluripotent cells after four days."

134 comments

  1. Totipotent first post! by Anonymous Coward · · Score: 2, Funny

    All subsequent posts are pluripotent and require this fp to proceed.

  2. Sounds very Frankensteinish by sandytaru · · Score: 3, Insightful

    I assume since the immune system is trained up together, there aren't issues with tissue rejection? Since scientists have created a way to turn ordinary skin cells into pluripotent stem cells (via a viral gene therapy process), are there any plans to try to reach this totipotent stage as well?

    --
    Occasionally living proof of the Ballmer peak.
    1. Re:Sounds very Frankensteinish by GameboyRMH · · Score: 3, Informative

      Chimeras occur in nature and AFAIK there are no negative health effects so I don't think tissue rejection is an issue...

      --
      "When information is power, privacy is freedom" - Jah-Wren Ryel
    2. Re:Sounds very Frankensteinish by ByOhTek · · Score: 1

      But, cross-species chimeras? I'm not familiar with that in nature.

      --
      Self proclaimed typo king, and inventor of the bear destroying coffee table (patent not pending).
    3. Re:Sounds very Frankensteinish by kurt555gs · · Score: 0

      The good news is soon they will be able to make better children. The right skin and eye color, smart, well behaved, healthy. And, these GM children will then vote for allowing GM food in every country in the world.

      Hail Monsanto!

      --
      * Carthago Delenda Est *
    4. Re:Sounds very Frankensteinish by Anonymous Coward · · Score: 0

      That's bad news for us, cellar dwellers.. in a world where everyone is perfect.

    5. Re:Sounds very Frankensteinish by GameboyRMH · · Score: 1

      I RTFA'd and still can't find where it says these are cross-species.

      --
      "When information is power, privacy is freedom" - Jah-Wren Ryel
    6. Re:Sounds very Frankensteinish by ZeroExistenZ · · Score: 1

      Go watch the movie Gattica.

      --
      I think we can keep recursing like this until someone returns 1
    7. Re:Sounds very Frankensteinish by AlterEager · · Score: 1

      Duh.

      GATTACA.

      There is no base called "I".

    8. Re:Sounds very Frankensteinish by Sir_Eptishous · · Score: 2

      GADDIKUH

      --
      We play the game with the bravery of being out of range
    9. Re:Sounds very Frankensteinish by shoehornjob · · Score: 2

      Researchers took very early stem cells, called totipotent stem cells, from separate developing embryos and basically glued them together, implanting the mixed embryos into surrogate mother monkeys. The cells â" from totally different sources â" didnâ(TM)t fuse, but worked together in harmony, forming fully fledged, normal, healthy animals.

      I suppose if the stem cells were fused it would be cross species but it's pretty clear they are seperate stem cells developing independant of eachother in the same womb.

      --
      "We are just a war away from Amerikastan. When god vs god the undoing of man." Dave Mustaine
    10. Re:Sounds very Frankensteinish by joocemann · · Score: 1

      The word "chimera" means it is cross species; the chimeric monkey being a mosaic of varied monkey species cells.

    11. Re:Sounds very Frankensteinish by joocemann · · Score: 1

      I = inosine, used as a base tht complements any of the 4 main bases. It isnt in natural nucleic acid, but is found in, for example, degenerate PCR primers where some nucleotides in the target sequences may be varied and whose positons are likely identified as single nucleotide polymorphisms.

      Basically, you can use inosine in place of the known complement, for sequencing or pcr, when the base it complements is unknown.

    12. Re:Sounds very Frankensteinish by kcitren · · Score: 1

      It is an probably an issue, but I'm not a biologist, geneticist, or anything related to medicine. What I do know is that females are far more likely to be chimera than males, and autoimmune disorders are far more prevalent in females than males. It seems likely that there's something going on there.

    13. Re:Sounds very Frankensteinish by GameboyRMH · · Score: 1

      I thought it just meant it was composed of cells with differing DNA.

      http://en.wikipedia.org/wiki/Chimera_(genetics)

      --
      "When information is power, privacy is freedom" - Jah-Wren Ryel
    14. Re:Sounds very Frankensteinish by Anonymous Coward · · Score: 0

      Just like with bone marrow transplants, as I understand it. The recipient's new marrow, though genetically distinct from the patient, grows immune cells which consider both the new marrow and the host as 'self'. I even read years ago (late 80's I think) that researchers had done this with animals prior to giving them organ transplants so that they considered the organs compatible.. would be nice if this got into use with humans ASAP, so kidney/liver/etc. transplants could be done without a need for lifelong drug treatment afterwards.

    15. Re:Sounds very Frankensteinish by Alphadecay27 · · Score: 4, Informative

      The word "chimera" means it is cross species; the chimeric monkey being a mosaic of varied monkey species cells.

      Your vast knowledge of greek literature (or alternately the AD&D monster manual) does not apply here. The term just means the animal has two distinct genetic pools.

      The original article specifies that: The chimeric monkeys were born after the researchers essentially glued cells from separate rhesus monkey embryos together. http://www.eurekalert.org/pub_releases/2012-01/cp-wfc010412.php

    16. Re:Sounds very Frankensteinish by imikem · · Score: 1

      That's Franken-STEEN! Sheesh.

      --
      Perscriptio in manibus tabellariorum est.
    17. Re:Sounds very Frankensteinish by EdIII · · Score: 1

      I figured the movie The Island of Doctor Moreau would be far more appropriate to the article.

      Although I doubt any researcher is going to be as creepy and perverted as Val Kilmer in that movie.

    18. Re:Sounds very Frankensteinish by holmstar · · Score: 1

      To do that, the current immune system needs to be eliminated. Being completely without immune system for any length of time is a very serious risk.

    19. Re:Sounds very Frankensteinish by hitmark · · Score: 1

      I recall reading about kids that had bone marrow transfusions at a early age ended up with a immune system that woulkd accept multiple blood types. I wonder if something similar could apply for tissue rejection...

      --
      comment first, facts later. http://chem.tufts.edu/AnswersInScience/RelativityofWrong.htm
  3. Damn you! Damn you all to hell! by Anonymous Coward · · Score: 0

    Did they name one of them Ceaser?

    1. Re:Damn you! Damn you all to hell! by Anonymous Coward · · Score: 2, Funny

      Who cares? I just want to know of any of them have four asses.

    2. Re:Damn you! Damn you all to hell! by GigG · · Score: 4, Funny

      Come on /. minions. Five whole minutes from the post of the story to the first post referencing Planet of the Apes. That is just sloppy.

      --
      Is buying a Harley Davidson as your first motorcycle since you were 16 at age 49 a midlife crisis issue?
    3. Re:Damn you! Damn you all to hell! by Pezbian · · Score: 1

      Kid stuff. Wake me when they have five asses.

      --
      In a world of the blind, the one-eyed man is king--and the two-eyed man is a heretic.
  4. Human-chimp hybrids coming soon? by yog · · Score: 5, Interesting

    Let's set aside all religious and moral/ethical concerns and look at the practicalities. A chimp with near-human intelligence would be a tremendous asset to both the military and private economy. They are much stronger and faster than humans, so would be incredible soldiers. They can ALREADY use sign language to communicate with humans, so just imagine taking that a step further--being able to type or write messages, maybe able to mimic human spoken language.

    They would make great athletic coaches, especially for gymnastic training and the like. They would be good nannies and playmates for kids, and could defend the kids from nasty people even more effectively than could a dog.

    I guess that leads to the idea of chimeric dogs. Just imagine a dog smart enough to identify someone and testify against him in court. "Yes sir, that's the perpetrator. I can smell him a mile away."

    --
    it's = "it is"; its = possessive. E.g., it's flapping its wings.
    1. Re:Human-chimp hybrids coming soon? by Anonymous Coward · · Score: 0

      Neo chimps, Neo Dolphins, Neo Dogs.... The Uplift Wars saga....

    2. Re:Human-chimp hybrids coming soon? by Anonymous Coward · · Score: 5, Funny

      Consider first, everything that you've ever done in front of your dog, and then ask if you really want them being able to talk.

    3. Re:Human-chimp hybrids coming soon? by ArcherB · · Score: 5, Funny

      Consider first, everything that you've ever done in front of your dog, and then ask if you really want them being able to talk.

      That goes two ways. I've seen my dogs do things they wouldn't want to be public knowledge.

      --
      There is no "I disagree" mod for a reason. Flamebait, Troll, and Overrated are not substitutes.
    4. Re:Human-chimp hybrids coming soon? by ByOhTek · · Score: 2

      Yes, but if they surpass humanity in too many regards... Planet of the Apes... err... chimps.

      --
      Self proclaimed typo king, and inventor of the bear destroying coffee table (patent not pending).
    5. Re:Human-chimp hybrids coming soon? by ae1294 · · Score: 2
    6. Re:Human-chimp hybrids coming soon? by Anonymous Coward · · Score: 1

      "They can ALREADY use sign language to communicate with humans, so just imagine taking that a step further--being able to type or write messages, maybe able to mimic human spoken language."

      They'd be able to write Shakespeare real fast.

    7. Re:Human-chimp hybrids coming soon? by rubycodez · · Score: 5, Informative

      No, Chimps are not great playmates nor nannies. If they get it into their head to attack, for many times unclear reasons, they instinctely follow a pattern of destruction of the enemy primates body. first they will gnaw off your child's fingers. Then they attack your precious little one's face by biting off parts. They then start to dismember, ripping off limbs.

      Chimps are unpredictable and extremely dangerous. Many people have been maimed or killed by their pet chimps.

    8. Re:Human-chimp hybrids coming soon? by Tsingi · · Score: 2

      A chimp with near-human intelligence would be a tremendous asset to both the military and private economy. They are much stronger and faster than humans, so would be incredible soldiers.

      I guess it's time we all watch the Planet of the Apes movie again. Just for a refresher.

    9. Re:Human-chimp hybrids coming soon? by cvtan · · Score: 1

      For the best talking dog story, see "Small" by H. Allen Smith. It's in a book called "How to Write Without Knowing Nothing". Very funny! http://www.amazon.com/How-Write-Without-Knowing-Nothing/dp/B0007DL4DM/ref=sr_1_4?s=books&ie=UTF8&qid=1325866453&sr=1-4

      --
      Sorry, but gray text on gray background is making my eyes bleed.
    10. Re:Human-chimp hybrids coming soon? by interkin3tic · · Score: 3, Funny

      They are much stronger and faster than humans, so would be incredible soldiers.

      I don't see them being worth the investment compared to a predator drone. What good would a chimp do in Iraq? Convince an informant to give up the location of an insurgent by pretending to smoke a cigar in a cute fashion? Throw poop at a IUD until it was deactivated?

    11. Re:Human-chimp hybrids coming soon? by K.+S.+Kyosuke · · Score: 4, Interesting

      Chimps are unpredictable and extremely dangerous. Many people have been maimed or killed by their pet chimps.

      Yeah, under no circumstances google any picture of Charla Nash.

      (Now observe people doing exactly the thing I told them not to do...)

      --
      Ezekiel 23:20
    12. Re:Human-chimp hybrids coming soon? by impaledsunset · · Score: 1

      How about Bonobos?

    13. Re:Human-chimp hybrids coming soon? by LordLimecat · · Score: 4, Insightful

      Let's set aside all religious and moral/ethical concerns and look at the practicalities.

      Now there's a worrying start to a conversation.

    14. Re:Human-chimp hybrids coming soon? by rubycodez · · Score: 2

      197 out of 200 bonobo owners and their family members surveyed couldn't answer, as they were being penetrated in all their orifices by bonobos. The other three were busy spitting out bonobo semen.

    15. Re:Human-chimp hybrids coming soon? by dkleinsc · · Score: 3, Funny

      Truman: Are you planning to make some kind of alien-human hybrid?
      Zoidberg: Are you coming onto me?
      Truman: Hot crackers, I take exception to that!
      Zoidberg: I'm not hearing a "no".

      --
      I am officially gone from /. Long live http://www.soylentnews.com/
    16. Re:Human-chimp hybrids coming soon? by Ragica · · Score: 1

      Nice try, Dr. Zaius, now back to your cage.

    17. Re:Human-chimp hybrids coming soon? by hey! · · Score: 2

      A chimp with near-human intelligence

      .. would not be a chimp. Aside from that, *all* of your ideas are highly impractical. Their strength and aggressiveness would make them *terrible* soldiers, because they'd be impossible to control. A lot of what makes armies effective are things humans are uniquely good at, like working together and suppressing our instinctual reactions.

      As for athletic coaches, the most important thing in a coach is an understanding of individual and group human psychology.

      The idea of using super-chimps as nannies comes from watching too many Tarzan movies, which use cute baby chimps. Next to polar bears, adult chimps are probably the most dangerously aggressive animal in the zoo.

      --
      Post may contain irony: discontinue use if experiencing mood swings, nausea or elevated blood pressure.
    18. Re:Human-chimp hybrids coming soon? by Anonymous Coward · · Score: 0

      Consider first, everything that you've ever done in front of your dog, and then ask if you really want them being able to talk.

      My dog cleans her own vagina 3 times a day. Huge slurping sounds for minutes at a time and occassionally gasps for air before finishing. I don't want to hear what she is saying.

    19. Re:Human-chimp hybrids coming soon? by FatherOfONe · · Score: 1

      Well put. I would say that the only thing that should be added is to also throw out all reason and sanity.

      --
      The more I learn about science, the more my faith in God increases.
    20. Re:Human-chimp hybrids coming soon? by ZombieBraintrust · · Score: 1

      These are not hybrid animals. A chimera is made up multiple dna from the same species. It occurs naturally when the embroys of twins fuse together.

    21. Re:Human-chimp hybrids coming soon? by Anonymous Coward · · Score: 0

      "They would make great athletic coaches, especially for gymnastic training and the like."

      Been done already, our NFL and NBA teams are entirely consisted of apes who are felons and have basic speech ability.

    22. Re:Human-chimp hybrids coming soon? by Patchw0rk+F0g · · Score: 1

      Well put. I would say that the only thing that should be added is to also throw out all reason and sanity.

      And I used up all my mod points before I got to the two of you. Damn it!

      --
      When the going gets weird, the weird turn pro. ~~ Hunter S. Thompson
    23. Re:Human-chimp hybrids coming soon? by interkin3tic · · Score: 1

      ... I think I may have meant IED: improvised explosive device. Throwing poop to inactivate intrauterine device contraceptives in Iraq would be even LESS useful.

    24. Re:Human-chimp hybrids coming soon? by wdef · · Score: 1

      197 out of 200 bonobo owners and their family members surveyed couldn't answer, as they were being penetrated in all their orifices by bonobos. The other three were busy spitting out bonobo semen.

      Some people in Jersey pay well for this service. Snooki, is that you?

    25. Re:Human-chimp hybrids coming soon? by sunwolf · · Score: 1

      Considering the physiological difference between humans and chimps, I doubt their effectiveness as coaches, no matter their intelligence.

      "Why don't you just grab the bar with your feet toes? Oh right, you don't have those."

    26. Re:Human-chimp hybrids coming soon? by Anonymous Coward · · Score: 0

      Is this an "All I want is a gorilla-juice-head" joke?

      Jacob

    27. Re:Human-chimp hybrids coming soon? by Anonymous Coward · · Score: 0

      o/~
      Headed down the hard way
      Concrete Battleground
      Urban monkey warfare
      Sabotage underground camouflage

      Man-monkey
      Monkey-man
      Urban gorilla
      o/~

  5. A picture of the scientists and the monkeys by erroneus · · Score: 1

    http://drexfiles.files.wordpress.com/2009/11/mugato_keeper_2.jpg

    I believe this is a picture of one of the scientists and one of their monkey subjects.

  6. And so begins... by rsmith84 · · Score: 3, Funny

    the Rise of the Planet of the Apes!

    1. Re:And so begins... by jgagnon · · Score: 1

      Led by Frankenmonkey.

      --
      Remember to maintain your supply of /facepalm oil to prevent chafing.
    2. Re:And so begins... by na1led · · Score: 1

      "Take your stinking paws off me you damn dirty ape!"

      --
      -- By all means let's be open-minded, but not so open-minded that our brains drop out.
    3. Re:And so begins... by jellomizer · · Score: 4, Funny

      He can talk?
      He can talk!
      He can talk?!

      I can Sing!!!

      Dr. Zaius, Dr. Zaius,
      Dr. Zaius, Dr. Zaius,
      Dr. Zaius, Dr. Zaius,
      ohhh, Dr. Zaius.

      --
      If something is so important that you feel the need to post it on the internet... It probably isn't that important.
    4. Re:And so begins... by rubycodez · · Score: 2

      Beware the beast Man, for he is the devil's pawn. Alone among God's primates, he kills for sport, or lust, or greed. Yea, he will murder his brother to possess his brother's land. Let him not breed in great numbers, for he will make a desert of his home and yours. Shun him. Drive him back into his jungle lair, for he is the harbinger of death. -- The Sacred Scrolls

    5. Re:And so begins... by ohnocitizen · · Score: 1

      In theory, this therapy can be used to treat a wide range of brain disorders. It's virtually limitless.

    6. Re:And so begins... by joocemann · · Score: 1

      The important take home message is that the chimera is formed of cells from different species, and developed relatively fine...

    7. Re:And so begins... by zawarski · · Score: 1

      I hate you all! From chimpan-a to chimpan-z!

  7. Not genetically engineered? by Sockatume · · Score: 2

    It seems to me that the manipulation was entirely mechanical and chemical, and that no modification of the genetic content of the cells happened at all. Which actually makes it all the more striking a result.

    --
    No kidding!!! What do you say at this point?
    1. Re:Not genetically engineered? by Hatta · · Score: 3, Informative

      No, it makes it less striking. Chimeras occur naturally when fraternal twin zygotes fuse at an early stage. The interesting result here isn't the production of the chimeras. There's no technical reason that we would want to create chimeras. The chimera is just proof that the stem cells they used were totipotent.

      --
      Give me Classic Slashdot or give me death!
    2. Re:Not genetically engineered? by Sockatume · · Score: 2

      I think it's interesting that genetically distinct cells will still properly coordinate for normal development, a striking example of the organisational abilities of the developmental process.

      --
      No kidding!!! What do you say at this point?
    3. Re:Not genetically engineered? by Hatta · · Score: 1

      Oh yes it is, but it's not a new result by any means.

      --
      Give me Classic Slashdot or give me death!
    4. Re:Not genetically engineered? by glwtta · · Score: 3, Informative

      There's no technical reason that we would want to create chimeras.

      Sure there is, most genetically engineered mouse models (for example) involve a chimeric step in their creation: stem cells with the desired modification are injected into 'donor' blastocysts and implanted into a host female, producing chimeras which are then bred for several generations to create homozygous offspring.

      --
      sic transit gloria mundi
    5. Re:Not genetically engineered? by interkin3tic · · Score: 1

      You're right, it's not genetically modified. The scientists involved don't seem to have made that claim in the Cell paper, nor does the Popsci article.

      This is actually a setback for making a genetically modified primate if I'm understanding it from the abstract. Genetically modified mice have been made for a while now. The process involves injecting embryonic stem cells which you've modified into the embryo. That makes a chimera (some of the cells are normal, some of the cells are modified). You then mate two such mice and hopefully should get some mice that are have one copy of the gene in every cell.

      Embryonic stem cells are somewhat easy to work with, you can grow as much as you need. Modifying the genes of a cell is not easy, but you only need one success.

      Panel one of the current paper shows that with primates, injecting modified embryonic stem cells doesn't seem to work: the embryos never incorporate those ES cells. They only incorporate todipotent cells, which are capable of making a whole organism (as opposed to ES cells which can make any cell TYPE but won't be able to make a complete animal on their own, as far as I know).

      Much less work has been done on todipotent cells, we have fewer tools for genetically modifying them than we do for ES cells. I've never heard of anyone genetically modifying them (though I don't follow that research closely.)

      So it would appear that making a genetically modified human or monkey will be much more challenging than making a modified mouse, which is already quite expensive and difficult.

    6. Re:Not genetically engineered? by Agent0013 · · Score: 1

      I remember someone here in a previous discusion about chimeras pointing out the male / female chicken chimeras that happen naturally. Check out this for a nice picture of a chicken that is two different colors, split right down the middle. In fact the two halves are different sexes as well. Or search google images for "chicken chimera" for pictures of others.

      --

      -- ssoorrrryy,, dduupplleexx sswwiittcchh oonn.. -Quote found on actual fortune cookie.
  8. Re:I'm very traditional by Anonymous Coward · · Score: 0

    I like entering a vagina with my penis.

    Lies!

    This is /. You're a virgin living in your parents basement.

  9. Great by assertation · · Score: 0

    Great, on top of global warming, nuclear war and overpopulation the establishment has to add the threat of making "The Planet Of The Apes" a reality too.

    Oh well, at least I'm not allergic to nuts.

    1. Re:Great by na1led · · Score: 1

      Come on, help a brother out! We're all part of the same family.

      --
      -- By all means let's be open-minded, but not so open-minded that our brains drop out.
    2. Re:Great by TheDarkMaster · · Score: 1

      You forgot "zumbi apocalipse", "giant meteor strike", "LHC goes wild"... :)

      --
      Religion: The greatest weapon of mass destruction of all time
  10. A Brave New Monkey by Kamiza+Ikioi · · Score: 1

    I can't wait until they can grow the cells upside down and shaking so they can work on the wings of our rocket planes while in flight.

    --
    I8-D
  11. Different genders? by jpapon · · Score: 1

    What would the outcome be if they mixed Totipotent cells from monkeys of different genders?

    --
    -- Let us endeavor so to live that when we pass even the undertaker shall be sorry. -- M. Twain
    1. Re:Different genders? by taiwanjohn · · Score: 1

      They would win a Nobel prize for discovering the only "niche" porn concept that doesn't yet have its own website.

      --
      XML is like violence. If it doesn't solve your problem, you're not using enough of it. --AC
    2. Re:Different genders? by Remus+Shepherd · · Score: 4, Informative

      Mixed-gender chimeras happen in real life. In general it's not a huge problem for the organism. One part of the animal contains the sex organs, and those organs are appropriate for the genes in that part. The hormones are often wacky, of course. Yes, you can get hermaphrodites this way.

      You may be under the impression that a chimera is a homogenous mix of cells from different gene lines. Actually, the gene lines usually occur in 'clumps' throughout the organism. The right arm might be all one gene line, while the torso is another, and the left arm yet a third. The clump around the lower abdomen will determine which sex organs develop.

      --
      Genocide Man -- Life is funny. Death is funnier. Mass murder can be hilarious.
    3. Re:Different genders? by Anonymous Coward · · Score: 0

      From TFS

      Totipotent stem cells are only derived from the very earliest stages of a zygote, mere days after fertilization. In humans, totipotent cells differentiate into pluripotent cells after four days

      Anything that has a gender does not have totipotent stem cells.

    4. Re:Different genders? by SuricouRaven · · Score: 1

      It shouldn't be that important. The only gene that determines gender is TFT, and all that does is make the testes form... everything else gender-specific is a consequence of the hormone produced there. So long as the gonads are of matching gender, the organisism as a whole should present as one gender anatomically. It's only if the chimeric line happens to run between the gonads that you'd get weird hermaphroditic outcomes.

    5. Re:Different genders? by SuricouRaven · · Score: 3, Informative

      Depends how you define 'gender.' Do you want an organism that is genetically male but anatomically female, or vice versa? That's easily done, certainly in any species that uses the XY chromosome system like humans. If no scientist has done it yet, it is only because there is no reason to. One tiny little genetic change to disable the TDF gene and you get a genetically male female, or one tiny adjustment to hormone levels in utero for a genetically female male. Humans don't start to develop gender-specific features until well into the fetus stage - they all start developing as a female. That is why men have nipples.

    6. Re:Different genders? by SuricouRaven · · Score: 1

      Typo, sorry: Meant to say TDF.

    7. Re:Different genders? by taiwanjohn · · Score: 2

      Well, TDF may be the only gene that determines gender, it's certainly not the only thing that determines how a fetus develops. The hormonal environment in the womb also has a huge effect, and seems to have a significant impact on sexual orientation as well as physiology. IANA biologist, but I suspect that the number of "natural" hermaphrodites resulting from chimeric mergers is vanishingly small.

      --
      XML is like violence. If it doesn't solve your problem, you're not using enough of it. --AC
    8. Re:Different genders? by jpapon · · Score: 1

      Thanks, I was not aware of that. I often find that my education as an Electrical Engineer has left me woefully ignorant regarding biology.

      --
      -- Let us endeavor so to live that when we pass even the undertaker shall be sorry. -- M. Twain
  12. Finally he has done it! by binarylarry · · Score: 5, Funny

    Behold! The six assed monkey!

    --
    Mod me down, my New Earth Global Warmingist friends!
    1. Re:Finally he has done it! by Anonymous Coward · · Score: 1

      Sadly it died out of depression. Too much poo and not enough hands to fling it with.

    2. Re:Finally he has done it! by Anonymous Coward · · Score: 0

      Behold! The six assed monkey!

      I'd be more surprised if they spliced elephant and pig DNA.

    3. Re:Finally he has done it! by Anonymous Coward · · Score: 0

      Don't you remember the song? "Pig and elephant DNA just won't splice!"

    4. Re:Finally he has done it! by Anonymous Coward · · Score: 0

      Fuck. You beat me to it. That's the first thing I thought about when I read this headline. If it has only three asses, it's of no use to me.

  13. The real question is by Anonymous Coward · · Score: 0

    was there 12 monkeys?

  14. Hey! Hey! We're the monkeys! by gestalt_n_pepper · · Score: 1

    I don't know why. I just felt like saying that.

    --
    Please do not read this sig. Thank you.
  15. The Rise of the Plant of the Apes by whitedsepdivine · · Score: 0

    Caesar has been born!

  16. Engineered chimera by Anonymous Coward · · Score: 0

    So I guess that makes it an engineered chimera, right ?

  17. 2012 GOP Candidate by drumcat · · Score: 1

    Clearly Newt & Santorum hadn't caught the same chimp look in the way W did. http://0.tqn.com/d/politicalhumor/1/0/l/7/bush_chimp.jpg

  18. RIP Troy McClure & Lionel Hutz by Thud457 · · Score: 2

    The best and brightest of a generation cut down by Zoloft.

    --

    the preceding comment is my own and in no way reflects the opinion of the Joint Chiefs of Staff

    1. Re:RIP Troy McClure & Lionel Hutz by Sir_Eptishous · · Score: 1

      Brilliant

      --
      We play the game with the bravery of being out of range
  19. Can they read Shakespeare yet? by Zcar · · Score: 1

    I mean, creating the works is one thing, but reading them...

    1. Re:Can they read Shakespeare yet? by laejoh · · Score: 1

      Writing is easy. One day I'd love to be able to read too!

  20. Planet of the apes by cod3r_ · · Score: 0

    Feel like I've heard this story before.. and it doesn't end well

  21. Why didn't they choose a meat animal? by Sentrion · · Score: 1

    I would have much rather preferred that they fused the cells of a chicken and a pig. I think chork or picken would be well received by the culinary industry. Chicken fused with tuna might even make a bigger splash. Imagine eating Chuna or Ticken straight out of a can of "Chicken of the Sea" brand chicken-tuna. Finally, the brand name for the popular canned meat would make sense. Mmmm!

  22. Re:I'm very traditional by Tsingi · · Score: 1

    I'm very traditional. I like entering a vagina with my penis. So, that high-tech crap the article is about is nothing for me.

    Chimps have Vaginas. Maybe you could get one that looks like Megan Fox.

  23. Hmmm by Anonymous Coward · · Score: 0

    I've seen this movie.

  24. Obligatory by Sir_Eptishous · · Score: 1

    George Taylor: A planet where apes evolved from men? There's got to be an answer. Dr. Zaius: Don't look for it, Taylor. You may not like what you find.

    --
    We play the game with the bravery of being out of range
  25. RoundUp resistant by Anonymous Coward · · Score: 1

    In other news ADM reports that these monkeys are RoundUp resistant, allowing mokey farmers to increase MYPA (monkey yield per acre).

  26. Re:I'm very traditional by K.+S.+Kyosuke · · Score: 1

    I'm very traditional. I like entering a vagina with my penis.

    I usually enter a door, but then again, I'm almost six feet tall... (And obviously, I don't leave my penis on the street most of the time.)

    --
    Ezekiel 23:20
  27. Chromosome 6? by Anonymous Coward · · Score: 1

    Did anyone read the book Chromosome 6 by Robin Cook? How much can we genetically alter apes / chimps before they become people? By replacing a simple chromosome in bonobos, those animals developed human-like traits -- including the ability to create and control fire.

  28. GNU breed? by macraig · · Score: 2

    'Cause, ya know, if they're not open source it'll make rooting 'em to turn 'em into Android monkeys just that much harder.

    1. Re:GNU breed? by joocemann · · Score: 1

      they absolutely are open source, coded in DNA, the language of life.

    2. Re:GNU breed? by macraig · · Score: 1

      Are you volunteering to lawyer that pitch for the next farmer Monsanto sues? Good luck!

    3. Re:GNU breed? by joocemann · · Score: 1

      I wish.

  29. Welcome, Chimeric Monkey Overlords by Anonymous Coward · · Score: 0

    I, for one, welcome our new Chimeric Monkey Overlords.

  30. Best line in the article by Anonymous Coward · · Score: 0

    "Nobody would ever create a chimeric human"

    WHEW!! Well, great, i'm glad to hear that. Let's list all the other things that 'Nobody' would ever do. The author clearly needs to read more science fiction...

    1. Re:Best line in the article by ZombieBraintrust · · Score: 1

      Well no one except your parents that is. Chimeric humans happen in nature.

  31. Throw poop at a IUD until it was deactivated? by wiredog · · Score: 1

    I think I saw that video on vchan.org/hc

  32. So what? by Anonymous Coward · · Score: 0

    Does this mean we're actually headed toward planet of the apes or will I finally be able to have my cat-girl soon? (link should be SFW)

  33. Oh Great by Anonymous Coward · · Score: 0

    Now 12 monkeys can infect 72 different species at the same time.

  34. name? by Anonymous Coward · · Score: 0

    Was his name Caesar?

  35. Science, morality and ethics by Dcnjoe60 · · Score: 2

    Let's set aside all religious and moral/ethical concerns and look at the practicalities.

    I can set aside religious concerns, but are you really proposing setting aside moral/ethical concerns? Would it be okay to create such a creature and have them fight our wars (whether for real or on the field)? One of the reasons people get concerned about technology and unbridled science is that all too often, moral/ethical concerns are left out of the discussion.

    For example, the technology to split an atom is, in and of itself, a neutral thing. Using the technology to provide a power source versus creating a weapon of mass destruction is a moral/ethical decision. Just like the Nazis couldn't get by saying "I was only following orders," scientists can't get by ignoring the moral/ethical considerations, either (of course I do realize that statement is a moral/ethical one).

    The moral/ethical implications of science and technology should not be left up to the scientist, but to society itself.

    1. Re:Science, morality and ethics by ifrag · · Score: 1

      scientists can't get by ignoring the moral/ethical considerations

      Actually, if you look into it, that's exactly what J. Robert Oppenheimer actually did. This paper provides some compelling reasoning to back it up: The Gita of J. Robert Oppenheimer.

      --
      Fear is the mind killer.
    2. Re:Science, morality and ethics by Dcnjoe60 · · Score: 1

      scientists can't get by ignoring the moral/ethical considerations

      Actually, if you look into it, that's exactly what J. Robert Oppenheimer actually did. This paper provides some compelling reasoning to back it up: The Gita of J. Robert Oppenheimer.

      From the link you gave:
      He believed that he had a job to do; that he should do it only because it was his job and not because he was intent on obtaining any particular result; and that following these principles would bring a saving measure of serenity into his profoundly discontented existence.

      The fact that he had to concoct such a rationalization to complete his work speaks volumes about what he, himself, knew about the moral/ethical implications of that work. The further fact that he was able to dismiss his own concerns, whether easily or not, is why the moral/ethical implications should not be left up to the scientist or team and should at a minimum have a higher review.

      Again, with the quote, I'm sure the guards involved with the Holocaust had a similar thought process.

  36. This can't be the first! by roman_mir · · Score: 1

    W

  37. human mouse chimeric cells by Anonymous Coward · · Score: 0

    have been used forever to do genetic studies and to harvest monoclonal humanized antibodies.

  38. How can nobody have made this joke yet? by LrdDimwit · · Score: 1

    It worked on the silkworms, so obviously Dr. Doom's sinister radioactive-spider genetic engineering scheme has been a success. It won't be long now before we see ...

    Spider monkey, spider monkey. Doing whatever a spider can.
    Look out! Here comes the spider monkey.
    Can he swing from a thread?
    Take a look overhead.
    Spider monkey!

  39. But this isn't serious... by rgbatduke · · Score: 1

    ... It's just monkeying around. If they wanted to do something serious, they'd try to e.g. intercalate human DNA associated with e.g. language or speech centers into chimpanzee or dog DNA. My dog's English sucks, and he's a mostly border-collie and speaks better English than most dogs. Why can't they try something useful for a change?

    --
    Even when the experts all agree, they may well be mistaken. --- Bertrand Russell.
  40. Welcome by Anonymous Coward · · Score: 0

    I for one welcome our new ape overlords!

  41. boiling the frog by Anonymous Coward · · Score: 0

    this is just a tip of the iceberg unveiling to soften us up for when the REAL clone army is released to the public. first it will appear more in movies so it will soften the blow, of it will be actual aliens either revived through DNA manipulation or ones present but in hiding. perhaps the LHC has something to do with this and what revelation book talks about in finding the "key to the pit" pit = black hole opening us up to another dimension where aliens abide.

  42. 3In1Monkey-Genes = {Hear,See,Speak}NoEvil+ by wdef · · Score: 1

    It's easy, only one line of code.

  43. Re:I'm very traditional by wdef · · Score: 1

    Poster did not specify the host species of the vagina he likes to penetrate. There is no reason to expect a /.'er living in a basement to prefer primate vaginas over, say, the more readily accessible canine vaginas, or - if you live in New Zealand or Wales - the vaginas of fluffy even-toed ungulates.

  44. and Scotland by Anonymous Coward · · Score: 0

    which is why they use kilts, so the fluffy even-toed ungulates won't hear a zipper

  45. Literary acumen by dewexdewex · · Score: 1

    Exactly how much faster can these "super monkeys" type?