Slashdot Mirror


Salt Linked To Autoimmune Diseases

ananyo writes "The incidence of autoimmune diseases, such as multiple sclerosis and type 1 diabetes, has spiked in developed countries in recent decades. In three studies published today, researchers describe the molecular pathways that can lead to autoimmune disease and identify one possible culprit that has been right under our noses — and on our tables — the entire time: salt. Some forms of autoimmunity have been linked to overproduction of TH17 cells, a type of helper T cell that produces an inflammatory protein called interleukin-17. Now scientists have found sodium chloride turns on the production of these cells (abstract). They also showed that in a mouse model of multiple sclerosis, a high-salt diet accelerated the disease's progression (abstract)."

60 of 308 comments (clear)

  1. Everything good is bad for you by Anonymous Coward · · Score: 5, Funny

    Salt, sugar, ethanol, nicotine, any food that isn't raw and tasteless--in an ideal healthy world, we would all eat a diet of cardboard and water and walk around flagellating ourselves all day.

    Enjoyable = sinful = unhealthy

    1. Re:Everything good is bad for you by Hal_Porter · · Score: 5, Funny

      I take this sort of story with a pinch of salt to be honest.

      --
      echo -e 'global _start\n _start:\n mov eax, 2\n int 80h\n jmp _start' > a.asm; nasm a.asm -f elf; ld a.o -o a;
    2. Re:Everything good is bad for you by HappyHead · · Score: 4, Insightful

      And once we are eating that diet free of salt, sugar, and all the rest of that, we'll all die of malnutrition since most of those things are (or are our primary source of) vital nutrients. The human body is a badly designed, self-destructing patchwork of bits that are perpetually one bad jolt away from a breakdown, so it's not surprising that they've discovered yet again, that excessive quantities of things we need to live will also kill us.

      Even water has an LD50 after all. Too much of it will leach away all of the electrolytes (including sodium chloride) from your body, and kill you.

    3. Re:Everything good is bad for you by Applekid · · Score: 2

      Major exception to your rule: sex. So long as you don't get an infection from it. I have yet to hear any study suggest that sex is bad for you.

      Not so. Sex can exasperate existing conditions and lead to heart attack or stroke. What a way to go, though.

      --
      More Twoson than Cupertino
    4. Re:Everything good is bad for you by denvergeek · · Score: 2

      It's got what plants crave!

    5. Re:Everything good is bad for you by K.+S.+Kyosuke · · Score: 4, Funny

      I have yet to hear any study suggest that sex is bad for you.

      You're not visiting the right churches.

      --
      Ezekiel 23:20
    6. Re:Everything good is bad for you by Dantoo · · Score: 5, Funny

      It would be awful to die all alone like that though........

    7. Re:Everything good is bad for you by hairyfeet · · Score: 5, Insightful

      And at the end of the day what does all this denial get you? Even Jesus didn't get out of here alive folks but let us say, just for the sake of argument they had a new "lets all eat cardboard" diet that made you live to 120....anybody spent any time with someone over 85? That is NOT a good life or a good way to be, most of your family is dead, your friends too, probably your spouse and maybe even a child or two, you're weak, your bones are easily broken, frankly death would probably be a blessing. My grandma lived to 98 and honestly those last 10 years were hell because she lost so many friends as well as her husband and oldest child...why? Why would you want that?

      I mean sure if they could give me a cyborg body so i could do everything I could at 30 at 90 that would be one thing but as it is now they just tack on years at the end, which is when it all goes to shit anyway...no thanks.,Give me an extra 10 years of being 20 or something, don't add years to the end.

      --
      ACs don't waste your time replying, your posts are never seen by me.
    8. Re:Everything good is bad for you by pavon · · Score: 5, Insightful

      The human body is a badly designed, self-destructing patchwork of bits that are perpetually one bad jolt away from a breakdown, so it's not surprising that they've discovered yet again, that excessive quantities of things we need to live will also kill us.

      Actually I draw the opposite conclusion from this. The human body is so amazingly flexible and adaptable, that it can survive on a huge variety of diets, and can compensate for poor diets so well that it can be difficult to realize the long-term effects that these poor diets are having, given the relatively benign short-term symptoms.

    9. Re:Everything good is bad for you by demonlapin · · Score: 2

      Not to be Debbie Downer, but if you think those are bad ways to die you've never seen someone die of metastatic cancer or emphysema.

    10. Re:Everything good is bad for you by rts008 · · Score: 2

      So, Jesus was a zombie?

      --
      Down With Slashdot BETA!!! I've been around the corner and seen the oliphant; you can only abuse me from your perspecti
    11. Re:Everything good is bad for you by s0nicfreak · · Score: 2

      I only know one person that lived over 90, but she was happy. She didn't realize she'd lost people... she thought their younger relatives were them. Then, she forgot they even existed.

      If we figure out how to live to 120, I don't see why we couldn't figure out how to have strong bones at 85. In fact, I think we already know how to do that, there are many healthy, active 85 year olds. It's just that it takes exercise and eating in a way you may not want to, for your whole life.

    12. Re:Everything good is bad for you by xevioso · · Score: 2

      Zombie Jesus day is right around the corner, btw.

    13. Re:Everything good is bad for you by Garridan · · Score: 2

      Cool thing about metastatic cancer: I got to spend an extra 11 months with my dad. No such thing if he'd had a heart attack.

    14. Re:Everything good is bad for you by lloydchristmas759 · · Score: 3, Informative

      I don't want to ruin your illusions, but if fish sauce or soy sauce taste salty, it's because there is a LOT of sodium chloride in them, so there is no benefit for health to use them instead of plain salt.
      Take a look at what's in soy sauce...

      However, some ingredients can be used as a replacement to salt and derivative to increase the taste of food, for instance lemon juice.

      --
      I'd give my right arm to be ambidextrous.
    15. Re:Everything good is bad for you by mpe · · Score: 4, Informative

      And once we are eating that diet free of salt, sugar, and all the rest of that, we'll all die of malnutrition since most of those things are (or are our primary source of) vital nutrients.

      It turns out that there is no such thing as an "essential sugar" in the human diet. Not even amylose or amylopectin...

    16. Re:Everything good is bad for you by SternisheFan · · Score: 2

      Better drink Brawndo It's got electrolytes.

      I prefer Bright-o. Bright-o makes ol' bodies new...

      It's a floor wax... And a dessert topping!

      "Delicious, and just look at that shine!"

      (Apologies to Dan Ackroyd & Gilda Radner)

    17. Re:Everything good is bad for you by Anonymous Coward · · Score: 4, Insightful

      My grandfather is 85. He's a computer geek who lives on microwave dinners. My father had the opposite lifestyle: Lots of exercise, and healthy food. He died from undiagnosed diabetes and high blood pressure at 62. Sometimes there's more to longevity than diet.

    18. Re:Everything good is bad for you by Bonobo_Unknown · · Score: 3, Informative

      You should read the article. No really. Because they mention exactly this. That it's not just a matter of eliminating salt, it is absolutely required, but that we tend to eat too much. Heck here's a copy / paste for you:

      To stay healthy, the human body relies on a careful balance: too little immune function and we succumb to infection, too much activity and the immune system begins to attack healthy tissue, a condition known as autoimmunity. Some forms of autoimmunity have been linked to overproduction of TH17 cells, a type of helper T cell that produces an inflammatory protein called interleukin-17.

      --
      We don't believe in radical loony monotheistic religions from the middle east -- we're Christians.
    19. Re:Everything good is bad for you by gosand · · Score: 2

      The human body is a badly designed, self-destructing patchwork of bits that are perpetually one bad jolt away from a breakdown, so it's not surprising that they've discovered yet again, that excessive quantities of things we need to live will also kill us.

      Actually I draw the opposite conclusion from this. The human body is so amazingly flexible and adaptable, that it can survive on a huge variety of diets, and can compensate for poor diets so well that it can be difficult to realize the long-term effects that these poor diets are having, given the relatively benign short-term symptoms.

      Look at the history of mankind and what we ate in order to evolve to this point. As is pointed out in the documentary "in search of the perfect human diet" if you started at the goal line of a football field and if that was the "dawn of man", and walked all the way to the other goal line, the span of time that we have been eating grains and sugars in large quantities would take up the last 1/2". For 2.5 million years our ancestors were meat-eating primates. The time we have been eating grains (10-20k years ago) is but a blink of an eye. Our bodies evolved eating high-fat diets, so all this low-fat high-carb stuff is literally killing us.

      --

      My beliefs do not require that you agree with them.

    20. Re:Everything good is bad for you by Anonymous Coward · · Score: 4, Insightful

      And at the end of the day what does all this denial get you? Even Jesus didn't get out of here alive folks but let us say, just for the sake of argument they had a new "lets all eat cardboard" diet that made you live to 120....anybody spent any time with someone over 85?

      Speak for yourself, you young whippersnapper, because I think life is still grand. I've gone from seeing computers that filled rooms of tubes to ones that fit on a desk to ones you can carry in your hand, each more powerful than the last. Granted, you kids these days have some crazy ideas. And won't stay off my lawn. But if I could live to 120 and still have the quality of life I do now, I'd find something useful to do with all that extra time. If nothing else, books are being written faster than I can read them.

      Eat meat and don't eat sugar or much bread. Walk every day. If the walking gets tough, take a bit of whiskey and walk anyway. I figure I have at least another good decade in me, although my eyes aren't what they used to be. Certainly, it is painful to lose friends and relatives over the years, and it is especially sad to see the children of friends who then became friends die of "old age". But life is still precious, and you kids have no idea how wonderful it is.

      Plus, we old people are keeping some amazing secrets from you. Hurry up with that immortality serum and we might decide to share.

    21. Re:Everything good is bad for you by demonlapin · · Score: 2

      Because obviously, his heart attack would have happened the same day as his death due to cancer.

      Just because you got to spend almost a year saying goodbye doesn't mean it's a good way to die. My wife had a maternal uncle die of pancreatic cancer and a paternal aunt die of (non-smoking-related) lung cancer. Both spent their final weeks - not days, weeks - on home hospice, moaning in pain until the time for another dose of morphine came. Then they drifted into unconsciousness for an hour or two before it all started again. In the end, he tried to kill himself (but his wife found the gun before he could), and she spent her last hours crying, moaning, and screaming for someone to make it stop.

      My father's metastatic cancer would have killed him if he hadn't developed renal failure requiring dialysis - he eventually elected to discontinue dialysis, correctly reasoning that fading away gently from uremia before the little crab crawled into every one of his organs and turned his every hour into a fresh torment of flayed nerve endings.

    22. Re:Everything good is bad for you by Beeftopia · · Score: 4, Insightful

      Actually, different ancient populations ate differently.

      Inuits (Eskimos) eat an extremely high protein, high fat diet. Not much farming in the far north.

      Nordic populations (Finns and Swedes for example) eat a diet different from Spaniards, who eat a diet different from sub-Saharan Africans who eat a diet different from southern Asians.

      It seems to me that there isn't a one-size-fits-all solution to diet. One needs to understand one's genetic ancestry, and then using that as a guide, figure out what's best for that person. What might be too much protein for a vegetarian south Asian farmer might not be enough for a Finn or an Inuit hunter. What might be too much fat or carbohydrate for one population might not be enough for another.

    23. Re:Everything good is bad for you by ozmanjusri · · Score: 3, Funny

      From Urban Dictionary:

      Christianity
      The belief that a cosmic Jewish Zombie who was his own father can make you live forever if you symbolically eat his flesh and telepathically tell him you accept him as your master, so he can remove an evil force from your soul that is present in humanity because a rib-woman was convinced by a talking snake to eat from a magical tree.

      Yeah, christianity makes sense.

      http://www.urbandictionary.com/define.php?term=christianity&page=2

      --
      "I've got more toys than Teruhisa Kitahara."
    24. Re:Everything good is bad for you by Sigg3.net · · Score: 2

      I can vouch for this. I'm Scandinavian and nourish myself by wrapping bacon around my naked body and just let it seep in overnight.

  2. The bottom line.... by Orleron · · Score: 2

    Don't eat or you will die.... oh wait.

  3. Bollocks by TechyImmigrant · · Score: 5, Insightful

    These finding are contradicted by the epidemiological evidence. The hazards of low salt are immediate and deadly. The hazards of high salt are hard to detect. The chances that there are other variables at work are high. Just because you have a pathway, it doesn't mean you've identified all the regulatory mechanisms.
       

    --
    I should use this sig to advertise my book ISBN-13 : 978-1501515132.
    1. Re:Bollocks by Pino+Grigio · · Score: 2

      I agree with this. My skeptical neurons started firing when I read the phrase "mouse model" in the synopsis.

    2. Re:Bollocks by kamapuaa · · Score: 3, Insightful

      http://www.medpagetoday.com/Cardiology/Hypertension/36248

      In 2011, for example, the Journal of the American Medical Association published a study by Stolarz-Skrzypek et al. that found only a weak correlation between salt and blood pressure

      --
      Slashdot: providing anti-social weirdos a soapbox, since 1997.
    3. Re:Bollocks by Mashiki · · Score: 2

      So please, stop the bullshit about fanciful and widespread health problems because there was no extra iodine added to salt. The problems are quite rare.

      Really. Odd that before the 70's, this was a pandemic level problem wasn't it. Oh I guess you must have been born in the 90's for you "not to see it much of a problem..." I guess this is one of those issues that we've already solved for you. Carry on then.

      --
      Om, nomnomnom...
    4. Re:Bollocks by reverseengineer · · Score: 2

      An issue I've seen with the use of mouse models in several places is that studies in mice (including this one) are based around a disease called EAE which can be readily induced in mice and which has many features similar to human multiple sclerosis. It's of course convenient experimentally to be able to induce what is normally a rare and unpredictable autoimmunity, but how well does that compare to human patients? Induction of EAE involves injecting mice with brain matter and pertussis toxin, in order to generate an inflammatory response to the mouse's own myelin. I wonder if the pathways for that induced imflammation are the same as for genuine autoimmunity, and whether the pathways of EAE really translate to multiple sclerosis, the causes of which are still rather mysterious.

      --
      "FDA staff reviewers expressed concern about the number of patients who were left out of the study because they died."
  4. Eat well and die young by Anonymous Coward · · Score: 5, Funny

    90 years of whole wheat is indistinguishable from death.

  5. yes, we used to die from flu ... by emilper · · Score: 3, Interesting

    yes, people used to die from flu, tooth infections and because of exhaustion when they traveled from Paris to Vienna in autumn by coach, now people live to 80+ until the system shuts down from almost anything ... soon we'll hear oxygen is linked to autoimmune diseases, diabetes and lack of interest in MSM

    it's called living, it is dangerous, and at the end, no matter what you do, you die

  6. Re:most salt is not real salt anyway by oodaloop · · Score: 4, Insightful

    Are you saying "processed" salt doesn't have sodium chloride? Or that natural salt doesn't?

    --
    Tic-Tac-Toe, Global Thermonuclear War, and relationships all have the same winning move.
  7. Sssshh! by JeanCroix · · Score: 3, Funny

    Nobody tell Bloomberg!

  8. Re:Hmm by v1 · · Score: 2

    another thing I love that I can't eat? they're just throwing more salt in my wound!

    --
    I work for the Department of Redundancy Department.
  9. Re:most salt is not real salt anyway by Narcocide · · Score: 2

    He's saying that natural salt doesn't have Bleach, Iodine, and non-binding agents.

  10. Doctors agree that healthy dietary salt intake... by QilessQi · · Score: 3, Funny

    ...is somewhere between 0 and 100kg per day. Now we just need to zero in on the exact number and we'll be all set.

  11. Re:most salt is not real salt anyway by Looker_Device · · Score: 3, Informative

    That iodine has done a LOT of good for public health.

    --
    Your political party doesn't care about your rights and only represents corporate interests.
  12. Re:Whelp by khallow · · Score: 2

    I thought that came from being next to Sweden and Russia.

  13. Mother Nature needs to give us kidneys...oh, wait by Comrade+Ogilvy · · Score: 4, Insightful

    The problem with these guesses about salt is our kidneys are specifically designed for actively and precisely maintaining homeostasis of certain key ions (Na, Cl, K, Ca) in the bloodstream. If it weren't we would simply die within days or sooner. Moderate salt with good hydration is probably not harmful at all -- it is probably good for you as it helps the kidneys filter other bad stuff out. Low salt could easily be bad for you.

    High salt plus low hydration might be bad. But where exactly is the line where moderate salt becomes high? Guessing based on what we eat is for witch doctors.

    So I would like to see an actual study showing how adding/subtracting a little salt changes anything measurable at all about the long term serum average, otherwise I am inclined to believe that this guess is baloney. We are not walking petri dishes.

    (There are specific diseases where controlling salts are very important, but that is a separate issue.)

  14. Don't believe everything you read. by TeknoHog · · Score: 4, Funny

    You should always take news like this with 64.79891 mg of NaCl.

    --
    Escher was the first MC and Giger invented the HR department.
  15. Too much salt by miltonw · · Score: 5, Insightful

    It isn't salt, it's too much salt. No one needs the huge levels of sodium chloride that is now added to most processed foods. It is there because it "tastes good" while making you want to eat more and more.

    I had to give up salt completely some years ago and it took months before I regained my ability to taste unsalted food. Now, food without salt actually tastes much better that the over-salted crap served to us everywhere.

    Yes, the body requires some sodium chloride but the amount is very small. What most people ingest is far, far beyond that. As with just about anything, too much will harm you.

    1. Re:Too much salt by miltonw · · Score: 2

      *sigh*

      There is far, far, far enough naturally occurring salt in food to supply all the salt that a body needs without having to add any. Perhaps, to be clearer for those who take things too literally, I needed to avoid all foods with any salt added to whatever naturally was there to start with.

  16. Re:most salt is not real salt anyway by h4rr4r · · Score: 2, Funny

    Because those folks are dying of diseases we already cured here. Stop the noble savage BS already.

  17. Re:Skeptical. by DragonWriter · · Score: 2

    Everyone has been eating low fat and low sodium for twenty years now, and look where we're at.

    Well, experts have been advising it. Everyone actually been eating that way? If they were, the entire fast-food industry would have collapsed.

  18. Re:most salt is not real salt anyway by Darkness404 · · Score: 2

    Correlation != causation.

    Why is it that developed nations lead in X disease and Y disease? A lot of it has to do with the fact that we screen for and treat these diseases rather than letting them go by unnoticed as they do in most of the less-developed world. Prior to modern medicine, a lot of now easily curable or treatable illnesses were fatal. Just look through a history book and you can see that a decent amount of children died not long after birth. Because of this, you've got people who are predisposed to getting sick living relatively normal, healthy lives in the west but in less developed nations these people would have died during childhood. Because of this we get this "skewed" idea that less developed nations are "healthier" which is not correct, it just is that those who aren't healthy have already died.

    --
    Taxation is legalized theft, no more, no less.
  19. Re:Didn't they mean... by Anonymous Coward · · Score: 2, Insightful

    Salt consumption declined at the start of the 20th century with the spread of refrigeration. Then through the 20th century it rose again as consumption of processed food grew.

  20. Re:most salt is not real salt anyway by Anonymous Coward · · Score: 5, Informative

    Been an engineer for a salt company for 20 years, the processing of salt is to take out the few impurities there are, we do not really add anything at all. There is no bleach, you do not clean 316SS that way when working with salt, salt kills bacteria as well as bleach could. You can easily get non iodine salt, the only additive is a inert agent to help it keep flowing in high moisture... (think of the rice in shakers, yeah its like that). "Natural" salt and Sea Salt, which we do make, is basically less clean, kinda nasty... but the crystal size and organization is different so it gives a different taste, quite nice on some things. But it is still nasty compared to good ole processed table salt, 99.9% pure and the last 0.1 is mostly encapsulated sand and our flow agent. Salt is CHEAP, we used to joke when crackpots (sorry valued customers) sent us complaints we were "cutting" the salt with something because it tasted less salty.... we looked it up, sand is much more expensive, not sure what we could cut it with that is cheaper! Oh and while we are at it, if anyone ever throws out salt due to a best buy date I will find them and smack them, we are forec to put those on, most of the US salt is at least 10k years old, it is not gonna bad anytime soon.

  21. Re:most salt is not real salt anyway by Narcocide · · Score: 5, Informative

    You know, when you are asking for a Citation like a smart-ass, maybe you should first make sure there isn't one to be found by searching the very site you're posting on.

  22. Re:Doctors agree that healthy dietary salt intake. by hedwards · · Score: 2

    The problem with salt is that it can be too low or too high. And, despite what doctors might say, it's not that hard to run low.

    Bottom line, is that it's how much you have in your brain and blood stream that ultimately matters more than your consumption does. If you're eating 2x the recommended amount, but sweating 3x as much as a normal person would, you will get sick eventually.

  23. Re:Mother Nature needs to give us kidneys...oh, wa by hedwards · · Score: 3, Insightful

    Moderate salt intake is mandatory, if you're not consuming any you'll eventually run low and wind up dead or brain damaged. And, that's not as hard as people think, all it takes is a few days of unseasonable weather if you've been low balling your consumption to get seriously ill. As in wind up in the ICU of the local hospital with life threatening brain damage.

    Yes, that's rather unlikely as most people consume so much salt that it would take weeks or more to run low, but it can and does happen.

  24. Re:Ignores Homeostasis by hedwards · · Score: 2

    Citation please. If that's really true, then why do so many people see their blood pressure improve by taken blood pressure medication that causes the excretion of sodium?

  25. Re:The bottom line... by c0lo · · Score: 2

    Multiple Sclerosis is a horrible disease that leaves you incapable of doing anything but sitting around waiting to die

    You're doing it wrong. Double the amount of salt in your diet, throw in some other pleasurable and unhealthy things in your lifestyle and I guarantee you'll never linger in this world until you get bored.

    --
    Questions raise, answers kill. Raise questions to stay alive.
  26. Hmm by Frankie70 · · Score: 4, Informative

    Taubes on Salt - http://www.nytimes.com/2012/06/03/opinion/sunday/we-only-think-we-know-the-truth-about-salt.html?pagewanted=all&_r=0

    While, back then, the evidence merely failed to demonstrate that salt was harmful, the evidence from studies published over the past two years actually suggests that restricting how much salt we eat can increase our likelihood of dying prematurely. Put simply, the possibility has been raised that if we were to eat as little salt as the U.S.D.A. and the C.D.C. recommend, weâ(TM)d be harming rather than helping ourselves.

  27. Re:The bottom line... by funwithBSD · · Score: 3, Funny

    Sin and salt and ruthless efficiency!

    --
    Never answer an anonymous letter. - Yogi Berra
  28. Re:Doctors agree that healthy dietary salt intake. by QilessQi · · Score: 2

    I do agree. Electrolytes are vital to a healthy body, and all it takes to put you in the "too low" category is a 24-hour GI bug accompanied by a half-dozen bouts of screaming into the porcelain microphone.

    And did you ever notice that sports drinks with electrolytes (like Gatorade) taste great when you're sweating and salt-deprived, and positively horrible when you're not?

  29. Actually, they DO consume MASSIVE amounts of salt. by denzacar · · Score: 3, Informative

    Also, butter. They make tea from it.

    They tend to eat or drink on average more than 20 grams of salt per day.
    They also tend to live 4900 meters above sea level. On average.

    --
    Mit der Dummheit kämpfen Götter selbst vergebens
  30. Sorry... there is no nutritional value in sugar... by gosand · · Score: 2

    I've been doing a lot of reading on dietary topics, and it is quite amazing how many opinions about our dietary needs are based on nothing but opinion or the opinions of other people. Even the scientific results can be mis-interpreted or looked at in so many ways that you can seemingly show whatever you want from these studies.
    There's a ton of stuff out there, like the book "Good Calories Bad Calories" that covers it in depth, but watch this video by Dr Peter Attia. I think it sums it up pretty well. The limits of scientific evidence and the ethics of dietary guidelines -- 60 years of ambiguity

    I've been following the Primal Blueprint lifestyle for a few months, and the effects have been pretty amazing.

    --

    My beliefs do not require that you agree with them.

  31. Re:most salt is not real salt anyway by deimtee · · Score: 2

    The major acid in your stomach is HCl. Any ionic* sodium you ingest is effectively immediately turned into salt. The "salt equivalent" measure is actually more useful than a straight NaCl measure for monitoring salt intake.

    *If you are ingesting non-ionic sodium, you should video it for medical purposes (and youtube).

    --
    I'm guessing that wasn't on their radar screen...