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How Farming Reshaped Our Genomes

sciencehabit writes "The earliest farmers may not have been built for the profession. They may have been unable to digest starch and milk, according to a new ancient DNA study of a nearly 8000-year-old human skeleton from Spain (a hunter-gatherer who had dark skin and blue eyes). But these pioneers did already possess immune defenses against some of the diseases that would later become the scourge of civilization. The findings are helping researchers understand what genetic and biological changes humans went through as they made the transition from hunting and gathering to farming."

40 of 144 comments (clear)

  1. Why is he unkempt? by BobMcD · · Score: 5, Insightful

    http://news.sciencemag.org/sit...

    Who says he let his hair and beard grow long? What evidence from the skeleton would have led to this conclusion?

    1. Re:Why is he unkempt? by ackthpt · · Score: 2

      http://news.sciencemag.org/sit...

      Who says he let his hair and beard grow long? What evidence from the skeleton would have led to this conclusion?

      Good ol' science, the kind where we immediately imagine things in our own image (he types as he strokes his luxuriant beard.)

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    2. Re:Why is he unkempt? by pesho · · Score: 4, Funny

      The five blade flint stone razor blade has not been invented yet.

    3. Re:Why is he unkempt? by Anonymous Coward · · Score: 2, Interesting

      You don't seem to realize a flint edge is actually much sharper than any metal blade -- that's why they use silica tips in atomic force microscopes; the tip is only a few atoms wide.

      People used to be very, very good at chipping flint blades.

      You may think a piece of plastic with one or metal blades will shave better, but you'd be wrong.

    4. Re:Why is he unkempt? by Moheeheeko · · Score: 4, Insightful

      Prehistoric spain was fucking cold, why would he remove a natural head covering?

    5. Re:Why is he unkempt? by bill_mcgonigle · · Score: 2

      Because he had shaggy hair and a beard before it was cool.

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    6. Re:Why is he unkempt? by E++99 · · Score: 5, Informative

      Flynt is sharper than any copper knife.
      Obsidian is sharper than any copper knife.
      Tribal people shave with flint to this day.
      There is archaeological evidence of shaving going back 20,000 years.

    7. Re:Why is he unkempt? by Moheeheeko · · Score: 2

      you try to burn your facial hair off, let me know how that works for you

    8. Re:Why is he unkempt? by Anonymous Coward · · Score: 2, Funny

      http://news.sciencemag.org/sit...

      Who says he let his hair and beard grow long? What evidence from the skeleton would have led to this conclusion?

      Look, they found him with a "Cobal Programming in UNIX for Dummies" book. What more evidence do you need?

    9. Re:Why is he unkempt? by Arker · · Score: 3, Insightful

      There are actually a handful of tribes that had that custom, the Yahi in california come to mind immediately. Plucking is also useful. But as a couple of other posters pointed out, the point about no shaving was specious to begin with. A high quality flint scraper is actually sharper than the best metal razor and yes they work just fine for shaving, if you are inclined to that activity.

      We really have zero evidence as to what the custom was in the time/space coordinates where the skeleton originates, so his personal grooming style and habits are entirely conjectural. Someone just thought he would look good as a hairy wildman so that is how he was painted.

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    10. Re:Why is he unkempt? by jellomizer · · Score: 4, Insightful

      Beards were rather popular in Ancient culture. A sign of manhood and variability. It took Alexander the Great to change that trend, pointing out that a beard could be grabbed in battle, so he ordered his troops to shave them off.
      However, it is a good way to protect your face, while hiding in bushes, and keeps your face warmer in the winter. It makes sense to assume that Hunters (Males) would have beards.

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    11. Re:Why is he unkempt? by BobMcD · · Score: 2

      I still think he may have fashioned/cut his hair and or beard in some way, rather that just letting it go wild.

    12. Re:Why is he unkempt? by xevioso · · Score: 2

      You could do this.

      Or you could grow a beard and a mustache and never have to worry again.

    13. Re:Why is he unkempt? by ignavus · · Score: 2

      http://news.sciencemag.org/sit...

      Who says he let his hair and beard grow long? What evidence from the skeleton would have led to this conclusion?

      They found a selfie on a nearby fossilized cellphone.

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  2. Being Hunter Gatherer... by ackthpt · · Score: 4, Interesting

    It means not being too choosy what you om-nom-nom on when the going is lean. Which likely means eating things which may have various parasites, mold spore, other fungi, even partially decomposed. "What luck! A partially decomposed squirrel with red rashes all over its body! Num!" That which didn't kill them, indeed make them stronger (those which survived, that is.)

    In today's scrubby, scrub scrubbed world of clean, inspected and otherwise near perfect world of meat, dairy and produce, we're not challenging our bodies very much. Further, we appear to be adapting to eating sugary, fried or other highly processed food, which means we say "Ewww!" when presented with ethnic foods we haven't seen before, which include the globby or wiggly bits of animals we don't see in the meat case at the market (which traditionally were the best parts, unlike the muscle which was often left behind.)

    Somewhat disconcerting how we haven't turned into beings which are entirely fed by capsule, a la the Jetsons "Oh, dear, I've overcooked the steak and potatoes pill."

    Fortunately, infants keep picking up dead bugs off the carpet and chewing on them, which gives them some bit of a test in developing their immune systems.

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    1. Re:Being Hunter Gatherer... by AMSmith42 · · Score: 2

      ...we appear to be adapting to eating sugary, fried or other highly processed food...

      I wouldn't consider epidemic rates of diabetes, cancer, heart disease and obesity "adaptation".

    2. Re:Being Hunter Gatherer... by operagost · · Score: 2

      Further, we appear to be adapting to eating sugary, fried or other highly processed food, which means we say "Ewww!" when presented with ethnic foods we haven't seen before

      Who is this "we" you are talking about?

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    3. Re:Being Hunter Gatherer... by Oligonicella · · Score: 2

      Those are major now prevalent in our culture because we've basically done away with the things that typically killed you first. Things that killed you more horribly and with greater percentages of the population, by the way.

      It's not epidemic, it's disclosure.

    4. Re:Being Hunter Gatherer... by ackthpt · · Score: 4, Interesting

      Nobody knows what was going on then. Everyone (the Paleo community included) stop saying how you know humans lived so and so many years ago.

      For all we know, they had an organic food paradise. Fresh fruits and vegetables right off the plants and fresh just-slaughtered grass fed meat to eat.

      Rather like you can read the life of a tree by its rings, you can tell a lot about the diets of people by the condition of their teeth at death, build of their bones and some of the elemental composition. Science is more scientific than ever, which is cursed on a regular basis by those who won't credit it.

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    5. Re:Being Hunter Gatherer... by cusco · · Score: 2

      Nobody knows what was going on then.

      We know exactly what they ate and how it was prepared. We have their copralites, their fossilized crap. We have their homes. We have their garbage dumps. We have their skeletons. It's not deep dark mystery, basic scientific analysis of human remains can let us know how far they traveled from their birthplace (isotopic analysis of bone growth), how often they experienced food shortages (bone density), what type of diet they had (trash midden excavation), what intestinal parasites they had (copralite analysis), what the climate was like (pollen analysis), how food was prepared (fire pit excavation, trash midden excavation, copralite analysis), and so on. If you were at all aware of the advances in archeological techniques of the last half century you would realize how incorrect your statement was.

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  3. Handful of genome samples does not a species make. by zooblethorpe · · Score: 4, Interesting

    What is this silliness, that "humans" in the broad, blanket sense could not digest starch? Feh.

    We already know from analysis of Neanderthal remains that they could digest starch, and did in fact eat things like starchy tubers and grains. By 8000 years ago, it's generally accepted that the Neanderthals were no more, at least as a distinct population, and that any remaining Neanderthal-specific genes had been absorbed by the wider Cro Magnon population. (Interestingly, it sounds like the Neanderthal genes might give their descendants, i.e. non-sub-Saharan-Africa humans, extra resistance to viral infection.)

    This study, where evidence from one individual is extrapolated to the entire human population, sounds silly in the extreme. "One Size Fits All!" never really does.

    Cheers,

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  4. Inability to digest milk by kruach+aum · · Score: 2, Interesting

    makes breasts a curious adaptation.

    1. Re:Inability to digest milk by WillAffleckUW · · Score: 2

      You're confusing the milk from other animals with human breast milk.

      Humans can - and have, historically - use that as their sole food source up to 5 years old.

      The problem arises from using milk from other creatures.

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    2. Re:Inability to digest milk by alvinrod · · Score: 4, Informative

      The composition of the milks are different. Cow milk contains more protein in general, and some proteins that are not found in human milk. Some people are unable to process those proteins. Also, intolerance to milk of any kind generally occurs later in life. If an individual were not able to digest it in infancy they would die and their genes would not be passed on. Perhaps with modern medical science, they would live, but this would not have been the case thousands of years ago.

    3. Re:Inability to digest milk by Valdrax · · Score: 4, Informative

      Humans, like most mammals, can universally digest lactose in childhood. Also, like most mammals, the gene for producing lactase largely shuts down in adulthood, since in nature, it's largely unneeded and a waste of energy resources. People descended from milk-drinking cultures (mostly Europeans) have variations of a gene that prevent lactase production from turning off in adulthood.

      Of course, this has little to nothing to do with breasts, since humans are the only primates that have visible breasts when not nursing their newborn young, and even then they are much, much smaller than in humans. It's most likely they exist purely for sexual signalling (like a peacock's tail), since their size is mostly irrelevant to their function in child-rearing.

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    4. Re:Inability to digest milk by orient · · Score: 2

      My friend's kid is intolerant to some component in the milk found in North American stores - at least Canada and US. However, he has no issue drinking milk originating from Central and Eastern Europe.

      --
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    5. Re:Inability to digest milk by Your.Master · · Score: 2

      Size definitely does matter for milk production

      Nope. The size (when not breastfeeding) is from the amount of fatty tissue, which is unrelated to the amount of milk-producing glandular tissue. It's possible to have not enough glandular tissue but it's very rare and takes insignificant space (enough glandular tissue to nurse exists in flat chested women).

      Higher fertility wouldn't explain things because 97% of the time, humans have only one child at a time. And humans make enough milk for twins anyway, even conveniently having two breasts for simultaneous feeding.

      I find it harder to gather information on wet nursing (we know that chimpanzees do wet nurse, but can't really give a rate) but let me express extreme skepticism that we had a significant selective pressure toward more milk production due to wet nursing. I can see *less* milk production as a plausible result of wet nursing, since it allows an optimized reallocation of milk resources. But regardless of whether wet nursing may or may not have increased or decreased human milk production, that's unrelated to breast size.

      As for the cultures, that's a very good point but the thing is, non-sexualized breasts doesn't mean they aren't a sexual signal. Men (straight men) are undoubtedly attracted to women's faces, and yet faces are not generally considered sexualized, and (depending on where you live etc.) you can see hundreds or more women's faces every day and think nothing of it. The theory would be that breasts are the same way. Even in cultures that don't hyper-sexualize breasts, and women walk around topless without drawing any stares or raised eyebrows, the men can be attracted.

  5. At the time .... by Anonymous Coward · · Score: 4, Insightful

    At the time, we humans needed a steady food supply. Hunting and foraging is too sporadic - and hence why we developed this ability to gain fat easily and it's a bitch to get rid of it. Feast or famine.

    Agriculture and the the high calorie grains like wheat and corn allowed us to survive and develop a society where we have farmers and other professions.

    Now that model is obsolete in the modern Western World, we are paying the price of our inability to adjust our taste buds.

    High calorie food tastes great! But we're not suffering from food shortages or doing enough physical work to justify those tastes.

    Wheat and corn didn't fuck us - our inability to judge our caloric needs is what screwed us.

    1. Re:At the time .... by jellomizer · · Score: 2

      The issue I am trying figure out about the new problems with getting fat. What is new that happened in the past 20 years?
      We had a lot of the same bad for us foods 20 years ago, and no food shortages either.

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    2. Re:At the time .... by PhxBlue · · Score: 3, Interesting

      Possibly the introduction of high-fructose corn syrup into everything that's artificially sweetened.

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    3. Re:At the time .... by suutar · · Score: 3, Informative

      and a reduction in average physical activity

    4. Re:At the time .... by HiChris! · · Score: 2

      High-fructose corn syrup is a not artificial - it's processed perhaps, but's it's natural. Loads of artificial sweeteners might indeed be an issue, but it's separate for HFCS.

    5. Re:At the time .... by drinkypoo · · Score: 5, Interesting

      Possibly the introduction of high-fructose corn syrup into everything that's artificially sweetened.

      No, and also no. It's the rise of processed foods, which come without the enzymes which break them down and thus help regulate blood sugar, and then the substitution of vegetable oil with HFCS, not simply its inclusion. Using HFCS instead of sugar is barely different. Using HFCS+Citric Acid instead of vegetable oil packs food with unnecessary sugar instead of the fats which give long-term energy. Thus, HFCS is used to do evil, but it's not really inherently evil in its own right. Like a gun, or a bomb.

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    6. Re:At the time .... by DuckDodgers · · Score: 2

      Keep in mind that, despite all the headlines built to grab ad revenue, the obesity epidemic in the US reached its peak in the late 1990s and obesity rates have been high but stable (not increasing further) since then. So the real question is what changed in food, plastics, personal eating habits, and social patterns from 1980 to 2000 but then stopped getting worse from 2000 until now.

      The other interesting thing to note is that much of the rest of the world - except the parts where people are starving - is experiencing its own growth in obesity rates.

  6. Lack of milk digestion seems dubious by goombah99 · · Score: 3, Informative

    All mammals are, by definition, born with the ability to digest milk, therefore they have the genes to do that. It can happen that those genes are epi-genitically turned off in adults that are not exposed to milk. However, the genes would be still there.

    Thus I'm extremely doubtful that any genetic studies could have revealed the lack of milk digesting genes. And since I don't see how they could assess any epi-genetic state of a long dead individual I really wonder about how they arrived at that conclusion.

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    1. Re:Lack of milk digestion seems dubious by Baloroth · · Score: 5, Insightful

      All mammals are, by definition, born with the ability to digest milk, therefore they have the genes to do that. It can happen that those genes are epi-genitically turned off in adults that are not exposed to milk. However, the genes would be still there.

      The genes for digestion are still there, yes, but they shut off after childhood unless you have a specific genetic mutation that allows lifelong production of lactase. Source 1, source 2.

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  7. Re:Wheat and corn fucked over the human race by jellomizer · · Score: 2

    In a Adam and Eve type of story, yes.
    Wheat and Corn, allowed for civilizations to grow and prosper.
    One of the premises in Jared Diamond "Gun Germ and Steel", is that the ability for a civilization to really grow we needed grain, otherwise the culture will stay in more of a hunter gather type of living. Major Civilizations, Mayans, and Aztecs had Maize/Corn type of grains, Middle East and Europe had Wheat, East Asia had Rice. This is because they were a rather High protein food, that can be easily dried and stored, so average guy didn't need to spend most of his life gathering food, and had time, to think and create and improve.

    So if you are living in a society you also get extra baggage, that often makes you think you want to long for the good old hunter gather days, forgetting about things such as illness, starvation, dehydration... So other then worry about if I will survive the next day, you worry about things like, how am I doing compared to the next guy, I am working too hard and I am not getting a fair pay from it.... While I am not trying to make these issues unimportant, they are an improvement over the problems that existed before. But they are some unnatural side effects such as self imposed stress, and a diet that may not be optimal...

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  8. Re:Wheat and corn fucked over the human race by cheesybagel · · Score: 4, Informative

    Incas had potatoes. It does not need to be a grain. But starchy foods are usually more effective in useful energy generated per acre.

    In the Pacific breadfruit was the staple. However it was so easy to grow there that there wasn't a lot of work 'farming' anything.

  9. Prehistoric Lactose-Intolerant Celiac by Irate+Engineer · · Score: 3, Funny

    Remains have been found of the first known lactose-intolerant celiac! Research is continuing, but he may have died of starvation as he had to send all his restaurant dishes back to the kitchen for including allergens. A compounding factor was all of his friends wouldn't eat out with him anymore because it was such a picky eater.

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  10. Re:Wheat and corn fucked over the human race by xevioso · · Score: 2

    One of the differences Diamond points out in his book is the difficulty in storing foodstuffs in certain climates. It's not too hard to store many grains that are commonly available in Europe and northern Asia, but go south and it becomes much more difficult to store foodstuffs like tubers and breadfruit for any period of time. This is significant because it allowed for people to do things rather than have to hunt for food all the time.