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Large Genetic Study Finds First Genes Connected With ADHD (arstechnica.com)

A paper published in Nature Genetics this week looked at genetic data from more than 50,000 people, finding 12 different regions of DNA that seemed to play a role in increasing ADHD risk. Ars Technica reports: This evidence comes from a genome-wide association study, or GWAS: a close look at how the DNA of people with ADHD differs from those without. Geneticist Ditte Demontis and her colleagues used data from more than 20,000 people with ADHD, comparing them to a control group of 35,000 people without an ADHD diagnosis. They found 304 points where tiny differences in DNA -- like single letter swaps -- were distributed across their two groups in a statistically telling way. If any of those variants were very close together, the researchers counted them as representing the same stretch of DNA, grouping them together into 12 important regions.

There were correlations between the genetic risk for ADHD and a range of other conditions, including depression and anorexia. That ties in with the idea that genetic variation might be important in a way that plays out system-wide. Some of the genes they identified are also known to be involved in other neurological conditions, including speech and learning disabilities, depression, and schizophrenia.

45 of 117 comments (clear)

  1. Re:Makes sense by jblues · · Score: 3, Funny

    Doh, I was going to make the first post, mentioning this, however I got distracted.

    --
    If it acquires resources on instantiation like a duck, then its a shared_ptr<Duck>
  2. Re:Makes sense by olsmeister · · Score: 1

    Ah, so that explains why Stormy did it. It was for science!

  3. Please leave these alone by Felix+Da+Rat · · Score: 2

    If humanity is to have any hope, it's going to come from the ADHD side of things. Cure all the diseases you want to, but please for the love of god, allow the natural flowering of creativity.

    Don't allow us to make drones and brainiacs - that will snuff out the species faster than any other eugenics program could.

    1. Re:Please leave these alone by rtb61 · · Score: 1, Informative

      Attention deficit hyperactivity disorder, means your environment has a activity deficit resulting in a disorder, it is all in the way you put it. So boring environments play havoc with the moods of some people and variabilities like socio-economic upbringing and diet and exposure to environmental pollutants (sound, radiation, visual, smells as well as consumed toxins), will all impact the condition and alleviate it or make it worse.

      Probably it would help if those who were genetically poorly set up to handle the current version of human society, were given more support and guidance earlier but capitalism demands the children pay the price for their loser parents, shit parents, well suck it the fuck up, the rest of society does not give one shit, unless it becomes life threatening, living poorly is you fault child, get a job or actually just fucking suffer is the answer, if you are dying or about to die then you can ask society for help as a child but up until that time, poor outcomes are just your lot.

      --
      Chaos - everything, everywhere, everywhen
    2. Re:Please leave these alone by Comrade+Ogilvy · · Score: 1

      I agree that there is probably a correlation between ADHD, creativity, and high intelligence.

      If we were to somehow remove the genetic tendencies and risk factors for ADHD from the gene pool, I bet we would lose more than half of our geniuses, more than that from the arts.

    3. Re:Please leave these alone by Anonymous Coward · · Score: 2, Informative

      That might be the case, but I'm not completely convinced. (Going AC because this shit is too personal).

      It's a vague diagnosis to begin with and it almost seems like today some wear it like a badge of honor and think they're somehow smarter than everyone else. Or at least they think maybe the drugs they get make them better students.

      I was diagnosed as "hyperactive" back in the '70s largely due to pressure on my resistant parents from a private school principal. Yes, a doctor did the actual diagnosing, but my parents thought I got into trouble sometimes because I was a bad kid. I never heard the terms ADHD or ADD until years later.

      My parents didn't like me being on Ritalin so after a year or two they switched to the Feingold Diet which seems like complete junk science to me now that I look at it as an adult.

      I can't remember if either had any effect on me at all other than it being a pain in the ass to take pills at first and then later to have to explain to my friends that I wasn't allowed to have a whole bunch of different kinds of foods including a goddamned chocolate bar (with few exceptions. Mounds was okay, but just about anything else was off limits.)

      By middle school we abandoned all that shit and I did reasonably well academically all the way through college when I graduated and became a regular part of the workforce.

      I know I'm intelligent (and fairly creative) and it's easy to accept the idea that I'm the smartest person in the room* so why should I try hard? That really did me in during Differential Equations in college. The first few weeks were so easy I started doing crosswords in class and blowing off homework until midterms when I suddenly realized I had a lot of catching up to do.

      And while I'm intelligent and have been reasonably successful in life, I've never done anything great or even noteworthy.

      I'm not sure if I really had ADHD back then or if I still suffer from it today. I know that sometimes I can concentrate for hours on something like software development, but at other times I find myself reading or watching a movie and suddenly realize that while my eyes may have been processing what's on a printed page or a screen, I have no idea what the hell is going on because my mind had wandered off somewhere in the complete opposite direction.

      But that doesn't happen all the time. Maybe it's just that I had things on my mind and that's completely normal.

      And if I do have ADD how is that related to my abuse of alcohol, if at all? Where does my social anxiety fit in? Maybe I'm mildly autistic?

      * - just a footnote. A lot of times I've been pretty sure I was one of the smartest in the room if not the smartest. I actually think I do better and am more comfortable when I know for a fact that I'm not the smartest person in the room or at least feel like I'm among people of similar levels of intelligence.

    4. Re: Please leave these alone by Anonymous Coward · · Score: 3, Informative

      The diagnosis is not really vague. There are specifics.
      If you don't really meet them strongly, you probably don't have it.
      I have a son with it and we knew even when he was a baby that he was different. Turns out he matches the textbook symptoms and it is only with medicine that he can cope with his disability, i.e, participate successfully in society, and he has only a moderate case. None of his other brothers have ADHD.

    5. Re:Please leave these alone by mikael · · Score: 1

      That's very true. I went to a state school with some ADHD kids who had been transferred in from other parts of the country? What triggered them? Boring lessons. History teacher who would make the class spend the entire hour just copying down notes from the blackboard. No discussion, just copy, copy, copy, then go to the next class. If you were lucky you managed to copy everything. If not, too bad. Language lessons would have everyone just stare at an overhead projector screen with pictures of things and their foreign language equivalent. And we'd go through these one after the other.

      Science teachers had a better way. You got laminated work cards that told you exactly what to do. Copy this paragraph, do this experiment, take these measurements, what conclusions can you make? If you didn't get all the work done in time, you took it home with you.

      --
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    6. Re:Please leave these alone by Gilgaron · · Score: 1

      That sounds worse than nuns breaking rulers over your fingers...

    7. Re:Please leave these alone by JMJimmy · · Score: 2

      I have ADHD-Inattentive type - it destroys every aspect of my life and offers no benefits in return. If they had a genetic therapy available, I would take it in a heartbeat.

    8. Re:Please leave these alone by azcoyote · · Score: 1

      Like Comrade Ogilvy, I agree in a general way; ADHD does seem to tend to present itself alongside extraordinary intelligence and creativity. However, just as they didn't find one and only one ADHD gene, it's really not the same for everyone, and not everyone with ADHD is necessarily a genius. It's true then that eliminating ADHD would probably bring about a net loss for human culture and achievement. However, achieving the most from ADHD requires proper treatment that is well-suited to the particular person. There are many, many cases where a person might even have a particular genius but is so unable to focus it that it amounts to nothing. This kind of genetic study is good because it could help us to better understand which treatments work better for which persons.

      --
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    9. Re: Please leave these alone by Anonymous Coward · · Score: 1

      ADHD kids require movement to learn

      https://psychcentral.com/news/2015/04/20/for-kids-with-adhd-movement-enhances-learning/83703.html

      Better to fit the learning environment to them than medicate them to suit school IMO, both being diagnosed myself and with 2 children diagnosed.

      Some of the characteristics that are considered symptoms in school are rewarded in the real world. Others only show up if you let yourself get bored.

      I need to keep active and not take boring jobs. Not much of a disability really, it just made me utterly unsuitable for traditional factory schooling.

    10. Re:Please leave these alone by cascadingstylesheet · · Score: 2

      If humanity is to have any hope, it's going to come from the ADHD side of things. Cure all the diseases you want to, but please for the love of god, allow the natural flowering of creativity.

      Don't allow us to make drones and brainiacs - that will snuff out the species faster than any other eugenics program could.

      ADHD != "the natural flowering of creativity".

      ADHD actually gets in the way of creativity by making it difficult to focus.

  4. Took long enough! by wolfheart111 · · Score: 4, Funny

    The Researchers kept getting distracted :(

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    [($)]
  5. This is all very interesting, but... by hyades1 · · Score: 1

    I'll be a lot more interested if they manage to locate genes connected with nymphomania...and a simple, anonymous test to find out who has them.

    --
    I've calculated my velocity with such exquisite precision that I have no idea where I am.
    1. Re:This is all very interesting, but... by angel'o'sphere · · Score: 1

      Yeah, but then we need a data breach and a flaw that connects the carriers of those genes with their address or phone number (a picture would be nice, too).

      --
      Cost free eBook I read (by iBook/Kobo/Amazon/ObookO/Gutenberg etc.): "The Green Odyssey" by Philip Jose Farmer.
    2. Re:This is all very interesting, but... by hyades1 · · Score: 1

      I would upgrade the importance of the picture.

      Call me shallow. I won't disagree.

      --
      I've calculated my velocity with such exquisite precision that I have no idea where I am.
  6. ADHD, the disease of not wanting to be confined by Jarwulf · · Score: 3, Informative

    in a four wall box all day long doing meaningless tasks for a giant abstract system or learning to do meaningless tasks for a giant abstract system that normal healthy humans naturally want to do.

    1. Re:ADHD, the disease of not wanting to be confined by AmiMoJo · · Score: 1

      That's like saying depression is the disease of being sad. It's not that they don't want to be confined, it's that unlike most people they can't handle it to the extent that without treatment they can't function in normal society.

      --
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    2. Re:ADHD, the disease of not wanting to be confined by cascadingstylesheet · · Score: 1

      in a four wall box all day long doing meaningless tasks for a giant abstract system or learning to do meaningless tasks for a giant abstract system that normal healthy humans naturally want to do.

      That's not what ADHD is at all. That's like calling clinical depression "being sad".

  7. Re: ADHD, the disease of not wanting to be confine by Anonymous Coward · · Score: 1

    No, ADHD is the disease of not being able to brush your fucking teeth and also figure out where you left your briefcase before you leave for work because you are too fucking distracted to focus and can't remember shit (poor working memory).

    You obviously have no intimate experience with ADHD.

  8. Re: by phantomfive · · Score: 1

    Funny how ADHD is really only a US thing

    It's not.

    --
    "First they came for the slanderers and i said nothing."
  9. Re: ADHD, the disease of not wanting to be confine by Jarwulf · · Score: 2

    Yeah thats every kid diagnosed and strung on Ritalin because their soccer mom can't handle them.

  10. Re: Makes sense by beckett · · Score: 1

    Lets ride bikes!

  11. Re: ADHD, the disease of not wanting to be confine by Anonymous Coward · · Score: 1

    parent: "strung on Ritalin because their soccer mom can't handle them."

    You misspelled frigid divorced single soccer mom whose hysteria is driven by the fact that she can't get her nut off even with the aid of a 15 amp industrial vibrator".

  12. ah yes, the link by slashmydots · · Score: 1

    Yes, shitty parenting that results in insufficient training in self-discipline does tend to be genetic, since they're genetically related to their kids. Very few people have actual ADHD compared to the sheer number with behavioral issues and impulse control.

  13. Re:ADHD what is it ? by mikael · · Score: 1

    France doesn't allow junk food, processed meat, soft drinks in their schools. Parents volunteer to help out at the school.

    --
    Vintage computer adverts: http://www.vintageadbrowser.com/computers-and-software-ads
  14. Text correction by sabbede · · Score: 1

    ADHD is a learning disorder. Thus, the last sentence should read, " including speech and other learning disabilities, depression, and schizophrenia."

    1. Re:Text correction by SinGunner · · Score: 1

      You'll find ADHD-negative people have a learning disorder compared to ADHD-positive people when the subject matter is of interest.

    2. Re:Text correction by Bengie · · Score: 1

      Mmmm hyper-focus. A few cycles of mind wandering and hyper-focus can get someone with ADHD well ahead of the game when it comes to topics of interest. Make everyone else look like they're mentally retarded. The "hyper" in this case refers to the impatiences of the ADHD person having to wait for everyone else.

    3. Re:Text correction by SinGunner · · Score: 1

      It worked great for me in Math and Physics because I like those. I'd read ahead while everyone else was learning the lesson because I couldn't stand the pacing. And because those subjects are cumulative, I'd be reading in order. It worked against me in History because I'd read the interesting parts, but I've never been in a class that covered the whole textbook, so I'd often read things that never made it into class and I really couldn't give a fuck the specific date something happened.

    4. Re:Text correction by sabbede · · Score: 1

      Yes, but it's still considered a learning disorder. One I also have.

    5. Re:Text correction by SinGunner · · Score: 1

      And America is considered a democracy or a republic, despite the fact it is clearly an oligarchy. Likewise, faith is not considered insanity. On Slashdot, pedantry is a virtue (as it really should be everywhere else). Dogma is a sin. Hence my correction of your "correction".

  15. Fake News by segedunum · · Score: 1, Informative

    'ADHD' is not a verifiable condition in any way shape or form.

    1. Re:Fake News by Skuld-Chan · · Score: 1
  16. Re:Look on the brighter side of life by Shaitan · · Score: 1

    You also get to think faster, act faster, and generally outperform the muggles who are deluded into thinking the next evolution of humanity is a disease.

  17. Re:Epigenetics? by MrLogic17 · · Score: 1

    Or maybe we're just lately treating people who think a little bit different as having a "disorder".

    Odd & quirky people have always existed. It's only lately that it's fashionable to throw labels and pills at them to get them to act like boring people.

  18. From someone with ADHD by burningcpu · · Score: 1

    Fuck you, die in a fire.

  19. Re:Look on the brighter side of life by Hylandr · · Score: 1

    God Bless you sir THIS !!

    Mod UP !!

    --
    ~ People that think they are better than anyone else for any reason are the cause of all the strife in the world.
  20. What? Were you saying something? by Chas · · Score: 1

    Dammit! Stop interrupting me!

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    Chas - The one, the only.
    THANK GOD!!!
  21. Champions of the Random Access Era by SinGunner · · Score: 1

    In this new era, ADHD is really coming into its own. It forces you to learn to process/simplify data faster, encourages the creation of external systems of organization and enables hyper-focus on areas of interest. These areas of interest may seem tangential at times, but relativity is the law of reality. Or as Dirk Gently might put it, the fundamental interconnectedness of all things.

  22. Re: ADHD is an ASSET by Bengie · · Score: 1

    Depends on what they mean by "ADHD". "ADHD" is many times used as a catch-all for both ADHD and ADD. I have ADD and I definitely could not do what I do without it. I took medication for several months and what I found is while my focus was greatly improved, my ability to creatively solve problems was destroyed while on it. I brought this up to my doctor and he said that a common complaint and actually recommended not taking medication unless I really needed to. He said it is common for people with ADD to have some form of extreme mental compensation, like the ability to hyper-focus when interested. He highly recommended learning to cope and practice using the strengths gained to compensate for the weaknesses.

    I've been learning to cope with ADD for many decades now. I find my best work is when I let my mind wander, which ADD is great at doing. I've learned to mostly be able to direct the wandering. I assume it's the dopamine rush of solving extremely difficult novel problems that no one else seems to be able to, that helps with directing.

  23. Re:Look on the brighter side of life by sexconker · · Score: 1

    You also get to think faster, act faster, and generally outperform the muggles who are deluded into thinking the next evolution of humanity is a disease.

    "I drive better when I'm a little buzzed."

    "I take weed and acid to open my mind. I'm much more lucid and effective when I'm high."

    And the real world sees you spazzing about, wrecking shit.

  24. Can we CRISPR it out of us then? by AbRASiON · · Score: 1

    They can do that kind of stuff now yeah?

    1. Re:Can we CRISPR it out of us then? by Areyoukiddingme · · Score: 1

      Can we CRISPR it out of us then? They can do that kind of stuff now yeah?

      Yes. And that's probably a bad idea. When a condition is so widespread in a species, there's a very good chance it's a species survival trait. Especially something that in an advanced form appears to be anti-survival. Heavily ADHD people have problems relating to people and so have problems reproducing. If the traits of ADHD are so important that an exaggeration of them is anti-survival, yet they're still present, they must matter quite a lot.