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We May Finally Know What Causes Alzheimer's -- and How To Stop It (newscientist.com)

We may finally have found the long-elusive cause of Alzheimer's disease: Porphyromonas gingivalis, the key bacteria in chronic gum disease. New Scientist: That's bad, as gum disease affects around a third of all people. But the good news is that a drug that blocks the main toxins of P. gingivalis is entering major clinical trials this year, and research published Wednesday shows it might stop and even reverse Alzheimer's. There could even be a vaccine. Alzheimer's is one of the biggest mysteries in medicine. As populations have aged, dementia has skyrocketed to become the fifth biggest cause of death worldwide. Alzheimer's constitutes some 70 per cent of these cases and yet, we don't know what causes it.

34 of 208 comments (clear)

  1. People, Just Floss by moehoward · · Score: 5, Funny

    Just floss people. And don't FORGET to floss. The more you floss, the less you will forget to floss. See how that works?

    --
    "If you want to improve, be content to be thought foolish and stupid." - Epictetus
    1. Re:People, Just Floss by Oswald+McWeany · · Score: 5, Funny

      Just floss people. And don't FORGET to floss. The more you floss, the less you will forget to floss. See how that works?

      I'm really not much of a dancer though.

      --
      "That's the way to do it" - Punch
    2. Re:People, Just Floss by Uteck · · Score: 4, Insightful

      Maybe this will prompt changes to include dental coverage in with medical and not some half covered separate insurance with limited payout.
      Diet is so important to your health, but getting damaged teeth fixed is expensive and mostly out of pocket. So you end up eating pre-processed crap that is bad for your health.

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    3. Re:People, Just Floss by ShanghaiBill · · Score: 2

      That is what I came here to say. Floss your teeth.

      No. Bad advice. Get a Waterpik. Waterpiks are more effective than string flossing at reducing plaque.

      Waterpiks are also faster and easier to use, and people are more likely to use them consistently.

      Add a jigger of fluoride mouthwash to the water, for even better results.

    4. Re:People, Just Floss by ShanghaiBill · · Score: 5, Informative

      I thought the culprit was metal, aluminum specifically from pots, un-coated aluminum cans, etc.,
      that found its way into the brain.

      No. This was debunked long ago.

      Myths about Alzheimers

    5. Re:People, Just Floss by ledow · · Score: 2

      And yet - there are almost no studies I can find where the statistics for Alzheimer's are directly correlative to dental health - literally it's death rate is low in low-health countries only because they die of other things first, but the incidence when that's factored out is the same.

      Even between developed countries with insane dental habits versus those more lax (e.g. Europe etc. it's not neccessarily normal to floss every single day, especially if there's not something stuck), Alzheimer's prevalence is the same.

      It's just not as simple as this summary seems to imply, and you can tell that by literally just comparing like-for-like countries that differ only in general dental habits (or even, say, against recorded instances of dental caries etc).

      Any kind of correlation like that it going to jump out at any Alzheimer's researcher like a sore thumb - they work with these people all the time and record every detail they can to try to track down even the most minor of correlations, even informally.

      P.S. Even the Wiki article on flossing says: "Several reviews, however, have failed to find any clear benefit over toothbrushing alone". It's literally only the US that flosses with any kind of gusto as a normal part of life.

      "In response to an Associated Press investigation, the US government stopped recommending flossing in their 2015 U.S. dietary guidelines, having deliberately changed their focus to food and nutrition, and stated that effects of flossing had never been researched as required."

    6. Re:People, Just Floss by LostMyAccount · · Score: 2

      I always assumed that crappy dental coverage was a byproduct of the fact that a lot of dental problems are preventable if you take care of your teeth.

      I actually think they should provide better coverage for major dental work like crowns and root canals, but worse coverage for fillings.

      Some of the problem may be shady dentists, too. I've run into dentists that are really big on pushing work that is pretty marginal in terms of necessity, and it seems like there's a lot of effort to push expensive products in the dental office (electric toothbrushes at retail+ prices, specialty toothpastes, etc).

    7. Re:People, Just Floss by omfglearntoplay · · Score: 2

      So like nobody I know in the US flosses regularly. Well, my dentist and his hygienist claim to. Some people are prone to gum disease, some are not. I almost never floss... never had a gum problem in my many decades of life. Hoping I'm staying in the 2/3 of the world who don't get gum disease. If you get it though, fuck me, go to the dentist, floss... rinse with garlic, eat cat litter, whatever the hell fixes it... because not only is alzheimer's a terrible way to get knocked down, you don't want gum disease breath to be how you get identified by your friends and family.

    8. Re:People, Just Floss by ShanghaiBill · · Score: 2

      Jigger? Could I get that converted into Football fields please?

      I have always used the term informally to mean more than a spoonful but less than a cup. But according to Google, "jigger" actually has a precise definition of 1.5 fluid ounces, or 44.36 ml. It is mostly used when mixing alcoholic drinks, and the device for measuring out precisely one jigger is also called a "jigger".

      A "football field" is an area, not a volume, so no conversion is possible. But the Rose Bowl has a volume of 20,000,000 cubic feet, which is 12,766,753,247 jiggers.

  2. Headline is a LIE, article makes that clear by Anonymous Coward · · Score: 5, Informative

    "Poor oral health is a risk factor for Alzheimer’s disease. What’s not clear is whether gum disease causes the disorder or is merely a result"

    EDITORS, EDIT !

    1. Re:Headline is a LIE, article makes that clear by Anonymous Coward · · Score: 4, Informative

      Did you read the *entire* article, or did you just stop when you got triggered?

      "Some brain samples from people without Alzheimer’s also had P. gingivalis and protein accumulations, but at lower levels. We already know that amyloid and tau can accumulate in the brain for 10 to 20 years before Alzheimer’s symptoms begin. This, says Lynch, shows P. gingivalis is a cause of Alzheimer’s, not a result."

    2. Re:Headline is a LIE, article makes that clear by gweihir · · Score: 2

      Actually, the article specifically discusses indications why the gum disease is likely the cause and not just an effect.

      --
      Most ACs are not even worth the keystrokes to insult them. Be generically insulted by this and ignored otherwise.
  3. Is the bacteria the cause or symptom? by mykepredko · · Score: 3, Insightful

    I remember twenty/thirty plus years ago when researchers found aluminum ions in the brains of Alzheimer's sufferers and there was the suggestion that cooking without aluminum pots and pans would prevent Alzheimer's. It seems that the aluminum ions were a symptom of Alzheimer's and not a cause - but on the plus side it gave steel cookware a good boost.

    If it's true that this bacteria causes Alzheimer's, then it's good news as it should be fairly easy to eradicate.

    1. Re:Is the bacteria the cause or symptom? by Anonymous Coward · · Score: 5, Informative

      Same with the beta-amyloid plaques found in the brain of Alzheimer's sufferers. I worked on a monoclonal antibody treatment about 10 years ago that targeted these clots. The antibodies broke them up good but did not alleviate the condition or prevent the plaques from returning. They were symptomatic rather than causative.

      Fact is, this is just another hypothesis among many. Other areas of interest are increased infection of herpes simplex (mouth sores) in the areas of the brain that are going bad. Antiviral trials are encouraging. Fungal infection has also been suggested since the disease is slow progressing like a fungal infection. Gum disease is just another hypothesis in a long line of em.

    2. Re:Is the bacteria the cause or symptom? by Ungrounded+Lightning · · Score: 3, Interesting

      That study was heavily flawed (as you note). Just to clarify a bit, it was performed on post-mortem brain samples. The aluminum found in Alzheimer's brains came from the solution they had been preserved in. (The Alzheimer's brains had been previously identified, set aside and preserved, while the non-Alzheimer's brains were sampled, uh, fresh.)

      Cue mass panic over soda cans, cooking ware, etc.

      But it was an easy flaw to believe in, as aluminum in the blood DOES cause dementia, as was discovered when the early dialysis machines were made with aluminum containers for the water bath.
      This led to "dialysis dementia syndrome", which limited the time a person with kidney failure could be kept alive on dialysis.

      Once this was figured out (early 1980s) the containers were changed, the dialysate treated to remove aluminum (and the use of aluminum-containing antacids as phosphate-binding agents reduced or discontinued.) Then people could be kept alive and reasonably healthy for long enough on dialysis to make it possible to wait for a transplatable kidney donation.

      --
      Bantam Dominique roosters crow a four-note song. Once you've heard it as "Happy BIRTHday" you can't NOT hear it that way
  4. Re:I already know by Oswald+McWeany · · Score: 4, Funny

    I already know the cause...well I did but I forgot about it. What are we talking about again?

    You were saying how much you loved Elon Musk, Tesla, space colonization, AI, self driving cars, and anything else high tech.

    --
    "That's the way to do it" - Punch
  5. Re:Nonsense by Anonymous Coward · · Score: 3, Insightful

    Aaaaaand we have the perfect slashcomment. Experts say X, someone stops in here, says it's false, provides no links, no proof, just an unflinching assertion.

  6. Best news in a long time by aristofeles · · Score: 2

    My grandma had it. My mother has it know, and it's getting worst.
    While I do believe it's too late for her, and even if it's available I will never have anything near the amount of money this may require, there is hope for me and my 2 brothers in 20 years (statiscally, one of us should have it).

    1. Re:Best news in a long time by laosland · · Score: 2

      I'm in the same boat as you. When my grandmother lived with my parents the last couple years of her life, it was really apparent how bad Alzheimer's really is. I really don't want to go through it, the last stage is a heart breaker.
      I'm really hoping that this research is correct.

  7. Re:Nonsense by MightyYar · · Score: 5, Informative

    Alzheimer's is distinct from vascular dementia. From this study:

    Metabolic syndrome was present in 15.8% of the study participants. The presence of metabolic syndrome increased the risk of incident vascular dementia but not Alzheimer's disease over 4 years, independent of sociodemographic characteristics and the apolipoprotein (apo) E4 allele.

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    W..w..W - Willy Waterloo washes Warren Wiggins who is washing Waldo Woo.
  8. If true... by tomhath · · Score: 3, Insightful

    "If borne out in clinical testing, COR388 could represent a wholly new approach to addressing a disease estimated to affect more than 5.4 million people in the United States." - Business Wire article

    I really hope this turns out to be a breakthrough. But as the debunked Buzzfeed story showed us, something prefixed with "if true" isn't necessarily true.

  9. This is like... by EvilSS · · Score: 2

    This is about the fifth thing in the past year I've seen that has been called out as the cause of Alzheimer. I really wish the media would stop jumping on these initial papers before they have been fully validated and reproduced.

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    I browse on +1 so AC's need not respond, I won't see it.
  10. Re:I dunno... by bobbied · · Score: 2, Insightful

    I thought the president is already suffering from dementia. I am not trying to troll.

    Of course you are trolling. Trump's mental status is not a question here, he's just fine in that regard. I fear some mistake Trump's lack of political sharpness as a mental problem, but it's really not.

    Trump's problem is he's unskilled in political speak, which starts with controlling what comes out of your mouth and the substituting the proper focus group tested catch phrases instead. He just says what comes to mind, which is often something which is ill advised. He's learning to not do this, but his first instincts about what to say are not tempered in the political correctness of the day.

    Also, Trump isn't taking guff off of anybody, politically, personally or otherwise. When he's attacked, he responds. Again, this is lack of political experience and caring for political correctness and is often seen as petty and vindictive. This is unusual behavior for political figures, but it's understandable.

    None of the above reflect on his mental status, but are personality traits. So you are trolling. Trump's mental status is just fine.

    --
    "File to fit, pound to insert, paint to match" - Aircraft Maintenance 101
  11. Re:I dunno... by bobbied · · Score: 2, Insightful

    Political leaders are usually narcissists as are CEO's and executive officers of large successful companies. It kind of runs with the territory.

    But the question really is if that's a problem for a president to be one? I don't think so.

    I was raised by a narcissist, so I'm quite familiar with their personality traits. Where I don't envy the folks who work for them, they tend to burn folks up with their demands, they can be very effective managers and good leaders at times.

    --
    "File to fit, pound to insert, paint to match" - Aircraft Maintenance 101
  12. sniff test by r2kordmaa · · Score: 2

    They were able to find some cases with Alzheimer, but no bacterial infection, perhaps they should look harder? 94% match in a sample size of 54 is hardly a case closed kind of thing. Good work nevertheless, but one should be a bit more careful before declaring groundbreaking success.

  13. Sugar causes plaque by ArhcAngel · · Score: 3, Insightful

    There's a reason they call Alzheimer's Diabetes 3.

    --
    "A person is smart. People are dumb, panicky dangerous animals and you know it." - K
  14. Six months ago, herpes virus was a possible cause. by DaveH_CO · · Score: 2

    https://www.sciencenews.org/ar... I guess I'm glad to see that they're looking for infections as to the cause...

  15. Re:I dunno... by necro81 · · Score: 2

    I fear some mistake Trump's lack of political sharpness as a mental problem, but it's really not....[C]ontrolling what comes out of your mouth and the substituting the proper focus group tested catch phrases instead. He just says what comes to mind....Also, Trump isn't taking guff off of anybody, politically, personally or otherwise. When he's attacked, he responds.

    I disagree. There is a difference for someone spouting unpopular opinions, not taking any guff off of anybody, etc., and the uninformed, incoherent drivel that comes from Trump's mouth. He seems to lack the ability to speak in complete sentences, goes off on rambling tangents, and refuses to accept contrary information.

    There are plenty of articulate trolls out there - people who can speak and debate eloquently about contrary positions, and insult the hell out of their opponents to boot. Trump, well, he's just like angry Uncle Joe that no one wants at Thanksgiving. It may not be a (clinical, diagnose-able) mental state problem, but it definitely is a mental fitness problem, and not an attribute I want in a President.

  16. Re:Dementia is possible - just unproven by vux984 · · Score: 2, Informative

    I saw an article that noted that Trump's use of language had deteriorated substantially compared to when he was younger.

    https://www.statnews.com/2017/...

  17. Re:Nonsense by lgw · · Score: 2

    Thanks. It's posts like this that keep Slashdot interesting, rather then just armchair experts making shit up.

    --
    Socialism: a lie told by totalitarians and believed by fools.
  18. Re:I dunno... by HiThere · · Score: 2

    The problem with calling it senile dementia is that it's not a recent development. It's not like Reagan, who was personable and vile, but lost his marbles during his term in office. Trump doesn't ever seem to have had any marbles to lose. He's been undependable and unreliable (as well as bigoted) as far back as is recorded. I suspect his grade school teachers would say he's improved "a little bit".

    --

    I think we've pushed this "anyone can grow up to be president" thing too far.
  19. Re:I dunno... by necro81 · · Score: 3, Insightful

    but I don't see how it's a problem that he chooses to say that stuff.

    Even when the things he says are obviously, demonstrably, and repeatedly incorrect? Don't you expect more from your leaders? I sure as hell do.

  20. Re:President is irrelevant by greythax · · Score: 2

    Strangely, I was thinking the opposite. For a while I have been assuming that this will be the presidency that makes us rethink how much power a single man should be invested with. Levying tariffs against Canada for reasons of national defense? The threat of using the US army on american soil for a construction project? While the powers themselves might make sense in genuine emergencies, there doesn't seem to be any mechanism to prevent their misuse, and clearly the senate and congress have been unwilling to provide oversight.

  21. More nonsense to sell pills by lamer01 · · Score: 2

    And, did you notice that they do not defeat the bacteria, just their toxins. So, we would need to be on their pills for the duration. BTW, my mother in law has alzheimers and she has perfect teeth. I know this is anecdotal but definitely proves there are other factors here.