You are making a very good point. Currently antibiotic resistance is a serious problem, mostly because we are very slow in discovering new antibiotics. What is very exciting about this research is that it significantly shifts the odds in our favor by allowing very large scale screens for new antibiotics. It will allow us to outpace the rate of resistance development. The probability that a particular infection will be resistant to multiple different antibiotics drops exponentially with the number of antibiotics you have. If you have a tool chest of 5-6 antibiotics sooner or later you will have pathogens that are resistant to a significant proportion of these antibiotics. Make the tool chest 10 times larger, and you will have a lot less to worry about.
Not to mention: antibiotic resistance isn't free. The mutation generally costs something.
A heavily armored bacterium that can barely move or eat may be highly resistant, but not very infectious...
3. Many people, due to age or disability, can't drive.
This is the one I like. My wife has a medical condition that keeps her from driving. Man would she love to just jump in the car and go somewhere when she wants to.
That said, I'm enough of a realist to have some anxiety about where this is going. There are people who would just love to have us limited to perfectly tracked, remotely shut-down-able little eggshells that can only go where they are allowed to go.
In addition all the nice little tax loopholes they used to profit from are rapidly closing so they from a tax perspective have to compete on an even footing with those bricks and mortar stores.
Way to learn the wrong lesson... instead of "huh, high taxes kill businesses, how about that", the lesson is {evil voice}"let no one escape"{/evil voice}?
I jsut don't get why all the people that will make streaming more popular than downloading are ignoring the obvious downsides of streaming vs. local storage:
1) You can't listen to your music when you dont have an active internet connection.
2) You're basically paying regularly/multiple times to hear the same music you could just pay for/download once.
Every time I organize or reorganize or back up my files, I'm paying for it, one way or another.
Time is worth something... space is worth something... mental energy is worth something.
$10/mo to have an impossibly vast music storehouse, maintained, backed up, and cataloged by someone else, is a bargain, in my book.
Eh. I used to buy at least one CD per month. Each CD cost more than I pay now per month for streaming, and I got a couple of good songs and some filler (most of the time) instead of thousands of good songs.
Yes, I could buy used CDs and store and organize them in my basement and digitize them all myself and store and back the digital files up in my own RAID array, and then they'd be mine, all mine my precioousssssss...
Or I can just pay 9.95/mo and not worry about any of that. I'll take option B.
If you work in Omaha Nebraska, you can walk away from a tech job you can't stand and have another job inside a week. At Pizza Hut.
I'm talking about having a group of friends and acquaintances with whom you can maintain face to face contact, who are able to help you out in a job search, which simply doesn't exist, if you're looking for a tech job, but don't live in a tech Mecca.
Huh. I must just be imagining that I live in a medium-sized metro area in flyover country (that nobody would think of as a "tech mecca")? Must be imagining that I've voluntarily changed jobs five times here, without more than a weekend between them. That for my most recent job I was hired (at a new company) by someone I had worked with two jobs ago. That this was over a period of years, that each job was better than the last.
Because that's only possible in tech meccas, right?
There's a strong bias to justify to yourself living in a high cost of living area.
One of the coolest client-side features of most SSH clients (at least OpenSSH and PuTTY support it) is the ability to turn any SSH connection into a SOCKS5 proxy, provided the server will let you.
Yep. I was using that nine or ten years ago, with Cygwin, to tunnel my http traffic from work through my home computer. Worked like a charm.
I was just talking to some people yesterday about the popular trend in offices to build open floor-plans in lieu of the traditional cubicles and dividers.
Actually, it's the open plan offices that are "traditional'. Watch an episode of, say, Barney Miller. Cubicles were this new-fangled innovation, etc.
Now it's coming full circle... meh.
Notice that the bigwigs always had their own offices, either way. With doors even.
Rather than address his shoddy argument, he claims he was 'doxed' instead, ignoring the fact it was his fault for associating his real name with his post in the first place.
Really? That's the problem? That you think he has a shoddy argument, not that he is being hunted and harassed for holding opinions that you and others don't like?
The above doesn't sound like Space X under Elon Musk. Space X is the plucky newcomer disrupting the existing American launch contractor United Launch Alliance (ULA) and its cosy relationship with the US military. If anything, ULA, Lockheed Martin, and Boeing fall under the moniker of "Robber Baron".
Exactly.
And honestly, we could use a few more "robber barons". Why should only the government be able to tax and hobble their competitors?
Banning prayer in school isn't tact by the religious to the non-religious. It's part of the separation of church and state, which became a big thing after two Christian groups had a violent falling out with each other in Europe and a bunch fled to the the US. The idea was that if you kept overt religious practice out of government and public activities (like education) then everybody (all Christians, or at least the more mainstream) could get along.
Several of the states actually had state churches. It was a ban on the federal government having a state church.
If you recall the World before the revelations began, though the subject was touched on in movies and forums such as this, it was not recognized as a foregone conclusion by hoopleheads until his information dissemination began.
Like him or not, call him hero or traitor... there is no way 'round observing the sowing of universal mistrust of governments he has instilled in our populace.
Serious question here... what "universal mistrust of governments"?
The same people who lionize Snowden eagerly supported the head of state who's been in charge of the NSA for the last six years. Eagerly supported the massive government takeover of health insurance. Eagerly supported... well, must I go on? This doesn't sound like people who distrust government.
The government that Snowden supporters want and are erecting doesn't really even need to spy on you; it freakin owns you already.
Some conservatives seem to hate him just for being a smart black guy who is associated with science. He's not even really an outspoken liberal or anything. He's just a smart black guy and it drives them CRAZY.
That's some serious projection you've got going on there. Is he "bright and clean" too?
That short Wednesday is baffling. On the longer days mom and dad can maybe stagger their schedule so they can handle it if they've got flexible employers, but that 5-hour day just looks like a gift to the local after-school care programs.
Dang, I thought our school district pioneered it. They certainly are alone in our area doing it.
Yeah, it sucks. Supposedly it is to allow time for meetings, paperwork, administration, etc. That countless school districts everywhere get by without it apparently doesn't matter.
Then there's all the crazy time off... every break is at least a day or three longer than when we were kids. WTH is "mid winter break"? Oh no, it's been a whole month or so since the two weeks off at Christmas. We need another break to get us by until Spring Break. Can't get too worn out before the three months off for summer.
The schools want to have parent level control over the kids, but certainly don't want to actually have to watch them all day, lol.
Slashdot Mirror
You are making a very good point. Currently antibiotic resistance is a serious problem, mostly because we are very slow in discovering new antibiotics. What is very exciting about this research is that it significantly shifts the odds in our favor by allowing very large scale screens for new antibiotics. It will allow us to outpace the rate of resistance development. The probability that a particular infection will be resistant to multiple different antibiotics drops exponentially with the number of antibiotics you have. If you have a tool chest of 5-6 antibiotics sooner or later you will have pathogens that are resistant to a significant proportion of these antibiotics. Make the tool chest 10 times larger, and you will have a lot less to worry about.
Not to mention: antibiotic resistance isn't free. The mutation generally costs something.
A heavily armored bacterium that can barely move or eat may be highly resistant, but not very infectious ...
3. Many people, due to age or disability, can't drive.
This is the one I like. My wife has a medical condition that keeps her from driving. Man would she love to just jump in the car and go somewhere when she wants to.
That said, I'm enough of a realist to have some anxiety about where this is going. There are people who would just love to have us limited to perfectly tracked, remotely shut-down-able little eggshells that can only go where they are allowed to go.
In addition all the nice little tax loopholes they used to profit from are rapidly closing so they from a tax perspective have to compete on an even footing with those bricks and mortar stores.
Way to learn the wrong lesson ... instead of "huh, high taxes kill businesses, how about that", the lesson is {evil voice}"let no one escape"{/evil voice}?
I jsut don't get why all the people that will make streaming more popular than downloading are ignoring the obvious downsides of streaming vs. local storage: 1) You can't listen to your music when you dont have an active internet connection. 2) You're basically paying regularly/multiple times to hear the same music you could just pay for/download once.
Every time I organize or reorganize or back up my files, I'm paying for it, one way or another.
Time is worth something ... space is worth something ... mental energy is worth something.
$10/mo to have an impossibly vast music storehouse, maintained, backed up, and cataloged by someone else, is a bargain, in my book.
I already have enough monthly bills.
Eh. I used to buy at least one CD per month. Each CD cost more than I pay now per month for streaming, and I got a couple of good songs and some filler (most of the time) instead of thousands of good songs.
Yes, I could buy used CDs and store and organize them in my basement and digitize them all myself and store and back the digital files up in my own RAID array, and then they'd be mine, all mine my precioousssssss ...
Or I can just pay 9.95/mo and not worry about any of that. I'll take option B.
If you work in Omaha Nebraska, you can walk away from a tech job you can't stand and have another job inside a week. At Pizza Hut.
I'm talking about having a group of friends and acquaintances with whom you can maintain face to face contact, who are able to help you out in a job search, which simply doesn't exist, if you're looking for a tech job, but don't live in a tech Mecca.
Huh. I must just be imagining that I live in a medium-sized metro area in flyover country (that nobody would think of as a "tech mecca")? Must be imagining that I've voluntarily changed jobs five times here, without more than a weekend between them. That for my most recent job I was hired (at a new company) by someone I had worked with two jobs ago. That this was over a period of years, that each job was better than the last.
Because that's only possible in tech meccas, right?
There's a strong bias to justify to yourself living in a high cost of living area.
One of the coolest client-side features of most SSH clients (at least OpenSSH and PuTTY support it) is the ability to turn any SSH connection into a SOCKS5 proxy, provided the server will let you.
Yep. I was using that nine or ten years ago, with Cygwin, to tunnel my http traffic from work through my home computer. Worked like a charm.
I was just talking to some people yesterday about the popular trend in offices to build open floor-plans in lieu of the traditional cubicles and dividers.
Actually, it's the open plan offices that are "traditional'. Watch an episode of, say, Barney Miller. Cubicles were this new-fangled innovation, etc.
Now it's coming full circle ... meh.
Notice that the bigwigs always had their own offices, either way. With doors even.
... a lot of people don't want it to be English.
It's jargon in active use, used by people precisely because it's not mainstream.
Exactly. It currently carries the scent of newness, youth culture, "in the know" trendiness. To deny that is silly.
Maybe someday it will just be a useful everyday word. Not yet.
It's not a secret that you have body parts. But it's a violation of your privacy to publish photos of them against your will.
Rather than address his shoddy argument, he claims he was 'doxed' instead, ignoring the fact it was his fault for associating his real name with his post in the first place.
Really? That's the problem? That you think he has a shoddy argument, not that he is being hunted and harassed for holding opinions that you and others don't like?
Their reasoning is mostly vindicated, as they keep voting for a government that takes from the imddle class and gives to their voter base.
So, in your country you can "leave your work, focus on your talent, your skill, your passion, your aspirations"?
You sure you aren't talking about the US?
For example, "direct input" officers teach nuclear theory to Navy nuclear field recruits. They don't go through real OCS (nor the Academy).
(Some of them were pretty cute, too ... or looked that way to someone who just got out of boot camp.)
If PUBLIC philanthropy does not achieve its goal, the general population has been looted and received no benefit in return.
And we all know that couldn't happen, as our land of full employment and racial harmony will attest.
The above doesn't sound like Space X under Elon Musk. Space X is the plucky newcomer disrupting the existing American launch contractor United Launch Alliance (ULA) and its cosy relationship with the US military. If anything, ULA, Lockheed Martin, and Boeing fall under the moniker of "Robber Baron".
Exactly.
And honestly, we could use a few more "robber barons". Why should only the government be able to tax and hobble their competitors?
Seife goes on to argue
There's more than one reason that I initially misread that as "selfie" ...
Banning prayer in school isn't tact by the religious to the non-religious. It's part of the separation of church and state, which became a big thing after two Christian groups had a violent falling out with each other in Europe and a bunch fled to the the US. The idea was that if you kept overt religious practice out of government and public activities (like education) then everybody (all Christians, or at least the more mainstream) could get along.
Several of the states actually had state churches. It was a ban on the federal government having a state church.
If you recall the World before the revelations began, though the subject was touched on in movies and forums such as this, it was not recognized as a foregone conclusion by hoopleheads until his information dissemination began.
Like him or not, call him hero or traitor... there is no way 'round observing the sowing of universal mistrust of governments he has instilled in our populace.
Serious question here ... what "universal mistrust of governments"?
The same people who lionize Snowden eagerly supported the head of state who's been in charge of the NSA for the last six years. Eagerly supported the massive government takeover of health insurance. Eagerly supported ... well, must I go on? This doesn't sound like people who distrust government.
The government that Snowden supporters want and are erecting doesn't really even need to spy on you; it freakin owns you already.
That is some seriously cool stuff. My hat is off to you, sir.
Tact is nice, but why does it always have to come from the side of the non-believer ?
Coffee/nose
Right ... gentle, kindly atheists everywhere, just dodging those nasty rampaging Presbyterians. How could I have missed it?
Some conservatives seem to hate him just for being a smart black guy who is associated with science. He's not even really an outspoken liberal or anything. He's just a smart black guy and it drives them CRAZY.
That's some serious projection you've got going on there. Is he "bright and clean" too?
It's lefties who are race-obsessed.
That short Wednesday is baffling. On the longer days mom and dad can maybe stagger their schedule so they can handle it if they've got flexible employers, but that 5-hour day just looks like a gift to the local after-school care programs.
Dang, I thought our school district pioneered it. They certainly are alone in our area doing it.
Yeah, it sucks. Supposedly it is to allow time for meetings, paperwork, administration, etc. That countless school districts everywhere get by without it apparently doesn't matter.
Then there's all the crazy time off ... every break is at least a day or three longer than when we were kids. WTH is "mid winter break"? Oh no, it's been a whole month or so since the two weeks off at Christmas. We need another break to get us by until Spring Break. Can't get too worn out before the three months off for summer.
The schools want to have parent level control over the kids, but certainly don't want to actually have to watch them all day, lol.
So kind of like Zope, but less portable.
so what is the difference if they are sitting in an office here vs. an office in Hyderabad or Bangaluru?
It's not as easy for their children to blow us up or cut off our heads?