Is there any suggestion that the etiology of the failures could be common across events? The Russians do have a fair bit of experience, although I suppose if the infrastructure supporting construction is poor, it doesn't matter how smart your rocket scientists are...
I already do that with my pager, but the topic of this thread was using Faraday cages to prevent signal transmission during movies. That would thwart the efforts of anyone who needs to quietly maintain a connection.
Images are collected in DICOM format (Digital Imaging and Communications in Medicine), which is an ISO standard for Health Informatics.
http://en.wikipedia.org/wiki/DICOM
Genome-wide association study (GWAS) results for Type 2 diabetes suggest a much larger footprint for islet cell dysfunction in T2D than previously thought. While the "insulin resistance" paradigm still works, we've had to adapt our model to include the more disordered insulin secretion indicated by these results. This is why unbiased and hypothesis-free research methods like GWAS are so powerful -- they aren't dependent on our preconceived notions of how things "should" be.
A nice review reference: Herder et al. Eur J Clin Invest. 2011;41(6):679-92.
Totally agree. This is actual news for nerds who are interested in how to effectively manage, and be managed, by other nerds.
Or, we could go back to arguing whether Autism is a fake diagnosis, based on, you know, our skill with Java.
I kid, I kid. Sort of.
They didn't predict anything. They retrospectively reviewed scans and determined a "signature" that correlated with the outcome studied. Without an independent validation cohort, this is interesting but far short of definitive. There are concerns about overfitting with such an analysis technique.
I really think we should come up with a team to figure out how in-home cold fusion reactors can be integrated into the existing power grid. This is a pressing issue, and I know if we work together we can achieve seamless integration.
How's 6pm on Thursday sound?
The term "personalized medicine" is a buzzword. We've been targeting specific environmental things in specific people for a long time now. It turns out it is hard to get people to get in shape, control their blood pressure, and quit their bad habits. Genetics is as personal as it gets, so that has become the new holy grail.
Genetics offers the ability to identify new risk factors and improve understanding of the underlying disease. Many of the identified common and even rare variants in disease don't lead to therapies, but they do tell us about the pathobiology, which may in turn lead to new discoveries and/or therapies.
We would love to study gene-environment interactions, but there are major power issues when trying to do studies like this in sporadic, complex disease like heart disease, hypertension, stroke, and the like. We're still trying to develop large enough sample databases and robust analytic techniques that allow us to study the interplay between millions of genetic variants and the often difficult to quantify or report environmental exposures that may act in concert in additive or even multiplicative ways.
The use of terms for sequence data and expression data are not interchangeable. The U133 microarray is for RNA, yes RNA, expression data. RNA microarrays quantify the fold change difference in expression between different subjects. DNA microarrays identify polymorphisms or repeats or the like. While arrays like the U133 rely on sequence level data to create the array, this is not the same as saying that sequence-level data is contaminated. Bottom line, the fact that this is not the cover article for Nature|Genetics this month tells you a lot of the story. Unless you are some sort of conspiracy theorist, or want to get swept up in the usual slashdot "sky is falling" imperative.
The wars of the future will not be fought on the battlefield or at sea. They will be fought in space, or possibly on top of a very tall mountain. In either case, most of the actual fighting will be done by small robots. And as you go forth today remember always your duty is clear: To build and maintain those robots.
If you just pick 24 random SNPs, they may not be particularly informative for your population (i.e. they may be monomorphic or have very low minor allele frequencies that don't help you discriminate individuals). So you want to pick markers that are bi or even tri-allelic with high MAFs for your population, to make sure they vary enough from person to person to tell them apart.
Sadly, a genotype fingerprint of just 24 well-selected markers is enough to differentiate an individual, with an error rate far lower than 1/ # of people on the planet. So while having names attached to samples is ethically deplorable, in practice it doesn't really even matter. I do genetic research, and the first thing we do is de-identify samples in the database. When we get samples from other sites with names still on them, we get pissed at the site. It's just sloppy, and certainly doesn't help the research.
You need vitamin D, sunlight, and working kidneys in order to render it useful.
You can get all the vitamin D you want in your diet, but without sunlight, it cannot be converted into a usable form by the kidneys. This is why they put northern Swedish and Norwegian kids under sun lamps for a few minutes every day. Thankfully, you really only need a few minutes of direct sunlight to covert enough vitamin D to last a while.
For such an interesting result, its a bit surprising that they went for "The Journal of Neural Engineering". Impact factor = 2.7. Only been around since 2004. I don't want to denigrate science that gets published in lower-impact journals (because lots of good stuff ends up there), but the impact here is not congruous with the potential scientific and social ramifications of the results. I think some of the issues raised above might have something to do with it.
I can only hope that this heavy-lift launch system will support a public option with early buy-in and that none of this NASA budget will be appropriated to state-supported abortions. Otherwise, it will apparently have a hard time getting through the senate.
Of note, this is single nucleotide polymorphism (SNP) genotyping, and NOT sequencing. Only 700K common variants will be genotyped. While individuals could certainly be identified in the database by their SNPs (as few as 24), this project does not employ high-throughput sequencing. The title of the summary is misleading.
So I can tell my wife that I cannot cook dinner tonight because the result would be so abhorrent that nature might send an agent back in time to destroy me before I can create it. Ergo, any movement toward making dinner could very well result in my demise...so let that be on her conscience.
I agree with this. While it sounds like mere rationalization to sell more ads, the reality is that ads are everywhere, and if you want realism, you need to replicate everything in the environment, including those pesky advertisements. I notice the fake ads in some games all the time, and it is a little jarring and detracts from the immersive experience.
Mod this guy up. As someone from a field who tries to separate signal from noise and develop predictive models on a daily basis (in supposedly well-controlled conditions) I can say that they have their work cut out for them.
I mean, I use proven methodologies in clear-cut and well-designed experiments and end up with data that is extremely difficult to manipulate (genome wide association studies). These guys/gals are trying to observe millions of humans interacting in indiosyncratic and complex ways with millions of input-points, and they think they can use that data? Talk about multiple-testing correction. Bonferroni is the tip of the iceberg in such a data-set.
The scary thing is, if you set something like this up, you will get "answers". It might be the result of a random walk, but who in the "jury of your peers" is going to understand that defense?
"But your honor, they didn't even define an acceptable false discovery rate!"
Slashdot Mirror
Is there any suggestion that the etiology of the failures could be common across events? The Russians do have a fair bit of experience, although I suppose if the infrastructure supporting construction is poor, it doesn't matter how smart your rocket scientists are...
I already do that with my pager, but the topic of this thread was using Faraday cages to prevent signal transmission during movies. That would thwart the efforts of anyone who needs to quietly maintain a connection.
Great. With your vision, doctors (or anyone else who needs to be pageable 24/7, like a sysadmin) can never go to a movie.
Images are collected in DICOM format (Digital Imaging and Communications in Medicine), which is an ISO standard for Health Informatics. http://en.wikipedia.org/wiki/DICOM
Linux on every desktop.
Genome-wide association study (GWAS) results for Type 2 diabetes suggest a much larger footprint for islet cell dysfunction in T2D than previously thought. While the "insulin resistance" paradigm still works, we've had to adapt our model to include the more disordered insulin secretion indicated by these results. This is why unbiased and hypothesis-free research methods like GWAS are so powerful -- they aren't dependent on our preconceived notions of how things "should" be. A nice review reference: Herder et al. Eur J Clin Invest. 2011;41(6):679-92.
Totally agree. This is actual news for nerds who are interested in how to effectively manage, and be managed, by other nerds. Or, we could go back to arguing whether Autism is a fake diagnosis, based on, you know, our skill with Java. I kid, I kid. Sort of.
They didn't predict anything. They retrospectively reviewed scans and determined a "signature" that correlated with the outcome studied. Without an independent validation cohort, this is interesting but far short of definitive. There are concerns about overfitting with such an analysis technique.
I really think we should come up with a team to figure out how in-home cold fusion reactors can be integrated into the existing power grid. This is a pressing issue, and I know if we work together we can achieve seamless integration. How's 6pm on Thursday sound?
The term "personalized medicine" is a buzzword. We've been targeting specific environmental things in specific people for a long time now. It turns out it is hard to get people to get in shape, control their blood pressure, and quit their bad habits. Genetics is as personal as it gets, so that has become the new holy grail. Genetics offers the ability to identify new risk factors and improve understanding of the underlying disease. Many of the identified common and even rare variants in disease don't lead to therapies, but they do tell us about the pathobiology, which may in turn lead to new discoveries and/or therapies. We would love to study gene-environment interactions, but there are major power issues when trying to do studies like this in sporadic, complex disease like heart disease, hypertension, stroke, and the like. We're still trying to develop large enough sample databases and robust analytic techniques that allow us to study the interplay between millions of genetic variants and the often difficult to quantify or report environmental exposures that may act in concert in additive or even multiplicative ways.
The use of terms for sequence data and expression data are not interchangeable. The U133 microarray is for RNA, yes RNA, expression data. RNA microarrays quantify the fold change difference in expression between different subjects. DNA microarrays identify polymorphisms or repeats or the like. While arrays like the U133 rely on sequence level data to create the array, this is not the same as saying that sequence-level data is contaminated. Bottom line, the fact that this is not the cover article for Nature|Genetics this month tells you a lot of the story. Unless you are some sort of conspiracy theorist, or want to get swept up in the usual slashdot "sky is falling" imperative.
The wars of the future will not be fought on the battlefield or at sea. They will be fought in space, or possibly on top of a very tall mountain. In either case, most of the actual fighting will be done by small robots. And as you go forth today remember always your duty is clear: To build and maintain those robots.
So we can't stop our poor dumb natural immune systems from attacking our own bodies, and we're just a few short years away from telling it what to do?
If you just pick 24 random SNPs, they may not be particularly informative for your population (i.e. they may be monomorphic or have very low minor allele frequencies that don't help you discriminate individuals). So you want to pick markers that are bi or even tri-allelic with high MAFs for your population, to make sure they vary enough from person to person to tell them apart.
Sadly, a genotype fingerprint of just 24 well-selected markers is enough to differentiate an individual, with an error rate far lower than 1/ # of people on the planet. So while having names attached to samples is ethically deplorable, in practice it doesn't really even matter. I do genetic research, and the first thing we do is de-identify samples in the database. When we get samples from other sites with names still on them, we get pissed at the site. It's just sloppy, and certainly doesn't help the research.
So is this 30x higher than the 100x higher that was reported here on Slashdot a few months ago? http://science.slashdot.org/story/09/10/06/1641232/Universe-Has-100x-More-Entropy-Than-We-Thought
You need vitamin D, sunlight, and working kidneys in order to render it useful. You can get all the vitamin D you want in your diet, but without sunlight, it cannot be converted into a usable form by the kidneys. This is why they put northern Swedish and Norwegian kids under sun lamps for a few minutes every day. Thankfully, you really only need a few minutes of direct sunlight to covert enough vitamin D to last a while.
For such an interesting result, its a bit surprising that they went for "The Journal of Neural Engineering". Impact factor = 2.7. Only been around since 2004. I don't want to denigrate science that gets published in lower-impact journals (because lots of good stuff ends up there), but the impact here is not congruous with the potential scientific and social ramifications of the results. I think some of the issues raised above might have something to do with it.
I can only hope that this heavy-lift launch system will support a public option with early buy-in and that none of this NASA budget will be appropriated to state-supported abortions. Otherwise, it will apparently have a hard time getting through the senate.
LIDAR; bred for its skills and magic.
So basically this is not permanent at all, just subject to the whims of yet another overlord.
Of note, this is single nucleotide polymorphism (SNP) genotyping, and NOT sequencing. Only 700K common variants will be genotyped. While individuals could certainly be identified in the database by their SNPs (as few as 24), this project does not employ high-throughput sequencing. The title of the summary is misleading.
So I can tell my wife that I cannot cook dinner tonight because the result would be so abhorrent that nature might send an agent back in time to destroy me before I can create it. Ergo, any movement toward making dinner could very well result in my demise...so let that be on her conscience.
I agree with this. While it sounds like mere rationalization to sell more ads, the reality is that ads are everywhere, and if you want realism, you need to replicate everything in the environment, including those pesky advertisements. I notice the fake ads in some games all the time, and it is a little jarring and detracts from the immersive experience.
Mod this guy up. As someone from a field who tries to separate signal from noise and develop predictive models on a daily basis (in supposedly well-controlled conditions) I can say that they have their work cut out for them. I mean, I use proven methodologies in clear-cut and well-designed experiments and end up with data that is extremely difficult to manipulate (genome wide association studies). These guys/gals are trying to observe millions of humans interacting in indiosyncratic and complex ways with millions of input-points, and they think they can use that data? Talk about multiple-testing correction. Bonferroni is the tip of the iceberg in such a data-set. The scary thing is, if you set something like this up, you will get "answers". It might be the result of a random walk, but who in the "jury of your peers" is going to understand that defense? "But your honor, they didn't even define an acceptable false discovery rate!"