PCP and ketamine were used as anaesthetics until the 60s/70s.
Actually, ketamine is still used occasionally as an anesthetic and for procedural sedations, particularly in children who have fewer side-effects from it. I wasn't in practice in the 60's and 70's, but I don't recall ever hearing about PCP being used as an anesthetic, and it's a doubtful thing considering it has no real value as an anesthetic that I can think of. My experience with PCP is thankfully limited, however.
Morphine is still widely prescribed, and I'm pretty sure the doctors don't know too much about it
Actually the action of morphine on mu opiate receptors in the brain is fairly-well (though not completely) understood.
If I'm wrong, correct me so I don't make the same mistake again.
Therefore the way that tylenol works is that it blocks this one enzyme. Since it seems related to pain let's call it COX-3
It's not nearly as simplistic as you assume. The cyclooxygenase enzymes are very well defined. We know them down to the atom. The myriad actions aren't necesarily understood in all parts of the body, but the mechanism by which they're involved in pain response is fairly well-understood. These researchers did not just pick "COX3" as the name out of blind stupidity. I'm assuming that the cyclooxygenase-3 is chemically very similar in both structure and function to the other two. There are at least hundreds and thousands of other enzymes related to pain response, but we don't name them COX just because they're related to pain.
I was impressed with Felton's use of the word "tinker" when in the/. community, such activity would clearly be known as "hacking." It has the same meaning, but not the same negative connotation to the mainstream. This way he still manages to get the point across without distorting the original intent. If you go through the article and replace the word "tinker" with the word "hack," it doesn't alter the meaning of the article at all. And clearly The Economist is on the "tinkerers" side in going along with the change in terminology.
Also, anecdotally, ask any first-person shooter gamer what the best interface is and most will say that keyb+mouse is the most efficient.
Yes, but any fps gamer (and I'm pretty avid an fps gamer) will tell you that the optimal interface is keyboard and MULTIBUTTON mouse. It's also the faster for regular OS navigation.
The DirectTiVo does a D/A conversion of the signal coming from the receiver, then a A/D conversion to store the picture on the hard disk
Incorrect. The DirectTivo's directly record the DirecTV mpeg2 stream directly to the hard drive. There is no mpeg2 encoder in the Directivo box, which is why you can record cable or OTA broadcasts using the DirectTivo. Get informed before you start spreading misinformation.
there aren't any $2000 imacs out there. Just thought I'd clear that up for ya
A quick trip to the Apple store shows an iMac with Superdrive and 17" LCD for $1,999. Even before adding memory or anything else to it, that comes to well over $2000 after shipping and sales taxes.
A good example of this is cancer. Cancer was uncommon in the 19th. century. By the end of the 20th. century it was the primary killer in Western countries.
Cancer has never been the primary killer in Western countries. Outside of industrial accidents in the early industrial age (I think), coronary artery disease and its relatives have pretty much held the #1 killer slot in the Western world for as long as such statistics have been available. Even today, heart disease is the primary killer by a fairly wide margin.
Think about all of the people who were infected by blood transfusions and whatnot.
In fact, we basically lost a whole generation of hemophiliacs, recently. A large percentage of them require intermittent blood transfusions, and nearly all of them contracted HIV before screening of blood products (overly delayed thanks to the govt). Pretty much all of them are dead now, since they contracted the disease generally before any other group did, and all died before the development of effective medical treatment.
We have probably lost a lot of sickle cell patients to AIDS too, but they generally have a rather limited lifespan for various reasons, though that is starting to change with newer medical treatments and immunizations.
I don't see the need to AC yourself. If they're doing it to you, they're doing it to thousands of job applicants around the country. Add to that the extreme unlikelihood that anybody from Costco's HR department even knows what Slashdot is, and I think you're pretty safe here.
Most doctors with office practices don't keep their patients around long enough to see the immediate effects of their medications. Being an emergency physician, I have the benefit of usually monitoring my patients for a few hours to judge response.
The migraine study didn't exclude "serious headaches." It excluded specifically those with "debilitating" headaches, i.e. those that are so bad that simply walking around is unbearable, who cannot even stand standard level room lights, who have unremitting vomiting, etc. And I agree, for those patients Tylenol alone simply isn't adequate. For many others, it may be enough.
I wouldn't expect Tylenol alone to resolve migraine headaches, but in 11% in the study it was enough to do the job. Personally, I never treat migraines with Tylenol alone, but it serves as a useful adjunct. Tylenol is always one of the drugs I use for migraine sufferers.
Re: the study of 14 people. To reach statistical significance with that small a study you have to get an amazing response to the medication. It may actually speak to the drug's benefit. I agree that it's not a particularly impressive study, though.
I don't know of any studies off-hand re: ordinary otc analgesics, but I'm sure there are plenty. Since they all have different mechanisms of action, they have varying effectiveness depending on the type of pain. The most dramatic example I can think of is pain from kidney stones. Due to its particular mechanism, cyclooxygenase-inhibiting NSAIDS such as ibuprofen (and ketorolac in particular) are far more effective than opioid medications (morphine, demerol, etc.). I've had patients to whom I gave massive doses of morphine (enough to put large animals to sleep), which only served to make them drowsy, but did nothing for their pain. One dose of ketorolac, and the pain was gone in 15 minutes, and they were heading for the door happy as a clam.
So, studies about effectiveness about pain-relievers depends greatly upon exactly what kind of pain you're studying.
And as far as drug company evil-intents goes, I think it's much less of a risk with Tylenol. Though it's widely used, it's patent is also expired, and the margins on acetaminophen can't be very high. Instead, I would be looking at the drug companies hawking newer expensive pain medications who try to downplay the effectiveness of the old standards.
In short, any doctors that have been telling you that acetaminophen is no more effective than placebo have been giving you false information. It is a very effective analgesic for mild to moderate pain. I know from my own experience that my patients often receive very good pain relief from plain old Tylenol, sometimes when other pain medications have failed.
Funny thing is Tylenol is less effective than sugar pills on a headache.
Citation, please? Double-blind studies have long-ago proven that acetaminophen is an effective pain-reliever against placebo. If you have definitive proof to the contrary, I'd be very interested.
Hospitals don't "proscribe" Tylenol for anything except perhaps liver failure patients. You probably meant "prescribe." And actually, hospitals don't prescribe a damn thing. The doctors still do that in my country.
The FSF has taken an interest in this case, and I think for obvious reasons. This is the perfect test case to take to court in order to validate the GPL. You have:
1) a well-documented violation of the license
2) from a well-respected project
3) by a less-than-quadrillian-dollar/year company that
4) openly admitted to the violation.
My guess is that the FSF is advising the XviD folks to take it to court and nail Sigma to the wall with a big iron spike through the heart. They won't get a better chance than this to prove the GPL.
That helps by actually getting money to worthy artists. This isn't all about screwing the RIAA, you know. I still buy CD's from indepedent labels, but at least I know they're more likely to be getting a decent share of the money that way. For those enslaved by RIAA labels, there's always Musiclink, for when you do feel like screwing the RIAA as well as paying the artists.
The RIAA member labels can be found here.
Don't buy music from them. There are plenty of good independent labels with good artists that deserve your money. Don't give it to those RIAA shills.
And became interested in swords, and fencing. In college, there was a fencing class, so a friend I took it. After a while, we considered buying our own swords. Eventually, we decided not to, because odds were that eventually, we'd want to play with them, and one of us would end up badly injured or dead. I think we made the right choice.
Funny, a friend and I had the same impulse in college. Both of us ended up on the fencing team. I eventually ended up as team captain, and we won four straight conference titles.
It keeps getting worse and worse. NT5 had an estimated 65000 bugs, if I recall correctly, but at a few grams per bug (when they don't fly), nobody cared about such a tiny mass. But now NT7 would be large enough for continental scale devastation? Wow. That must be a serious number of bugs.
Asimov did not coin the term "robot." He did however coin the term "robotics" to describe the study and creation of robots. Asimov goes into the etymology of the word "robot" somewhere in one of his bazillion books' forwards, I think.
Unless the UT system has done some purchases I've not heard about since I graduated from it (twice), UNT is not part of the Univ of Texas System. It is a separate institution, one especially well known for its jazz music program.
What would be really remarkable for UTD is if they could score Carmack to teach a class since he's also in the Dallas area, though a somewhat longer drive from the Mesquite offices of id Software. There isn't any question which class would be in higher demand, is there?
Lucas also reportedly told E! Online that the reason droids C-3P0 and R2-D2 have no memory of Anakin Skywalker/Darth Vader is because their memories have been wiped prior to the beginning of Episode IV, the original Star Wars movie.
I just finished watching ANH recently, and something odd occurred to me. I can buy Lucas' contention that the 'droids' memories were wiped prior to ANH, but that doesn't account for the fact that Ben Kenobi seems not to recognize the droids at all when they find him in the Tatooine desert. This is despite the fact that he spent some very pivotal moments in galactic history with those two. Is Lucas going to alter Episode IV to make up for this apparent gaffe as well?
I agree that you can't get a decent image from the tv out of most video cards. However, most of us who are using htpc's primarily aren't using the crappy composite or s-video outputs. Personallly I'm using the vga output from the card to drive a front projection tv, which delivers an excellent picture. A visit over to the htpc forums at avsforums will find lots of people doing the same or similar.
Slashdot Mirror
I was impressed with Felton's use of the word "tinker" when in the /. community, such activity would clearly be known as "hacking." It has the same meaning, but not the same negative connotation to the mainstream. This way he still manages to get the point across without distorting the original intent. If you go through the article and replace the word "tinker" with the word "hack," it doesn't alter the meaning of the article at all. And clearly The Economist is on the "tinkerers" side in going along with the change in terminology.
Cancer has never been the primary killer in Western countries. Outside of industrial accidents in the early industrial age (I think), coronary artery disease and its relatives have pretty much held the #1 killer slot in the Western world for as long as such statistics have been available. Even today, heart disease is the primary killer by a fairly wide margin.
In fact, we basically lost a whole generation of hemophiliacs, recently. A large percentage of them require intermittent blood transfusions, and nearly all of them contracted HIV before screening of blood products (overly delayed thanks to the govt). Pretty much all of them are dead now, since they contracted the disease generally before any other group did, and all died before the development of effective medical treatment.
We have probably lost a lot of sickle cell patients to AIDS too, but they generally have a rather limited lifespan for various reasons, though that is starting to change with newer medical treatments and immunizations.
I don't see the need to AC yourself. If they're doing it to you, they're doing it to thousands of job applicants around the country. Add to that the extreme unlikelihood that anybody from Costco's HR department even knows what Slashdot is, and I think you're pretty safe here.
I wouldn't expect Tylenol alone to resolve migraine headaches, but in 11% in the study it was enough to do the job. Personally, I never treat migraines with Tylenol alone, but it serves as a useful adjunct. Tylenol is always one of the drugs I use for migraine sufferers.
Re: the study of 14 people. To reach statistical significance with that small a study you have to get an amazing response to the medication. It may actually speak to the drug's benefit. I agree that it's not a particularly impressive study, though.
I don't know of any studies off-hand re: ordinary otc analgesics, but I'm sure there are plenty. Since they all have different mechanisms of action, they have varying effectiveness depending on the type of pain. The most dramatic example I can think of is pain from kidney stones. Due to its particular mechanism, cyclooxygenase-inhibiting NSAIDS such as ibuprofen (and ketorolac in particular) are far more effective than opioid medications (morphine, demerol, etc.). I've had patients to whom I gave massive doses of morphine (enough to put large animals to sleep), which only served to make them drowsy, but did nothing for their pain. One dose of ketorolac, and the pain was gone in 15 minutes, and they were heading for the door happy as a clam.
So, studies about effectiveness about pain-relievers depends greatly upon exactly what kind of pain you're studying.
And as far as drug company evil-intents goes, I think it's much less of a risk with Tylenol. Though it's widely used, it's patent is also expired, and the margins on acetaminophen can't be very high. Instead, I would be looking at the drug companies hawking newer expensive pain medications who try to downplay the effectiveness of the old standards.
Here's one for migraine sufferers.
And one in combination with morphine
How about one for cold-induced pain?
And this one for post-operative pain.
In short, any doctors that have been telling you that acetaminophen is no more effective than placebo have been giving you false information. It is a very effective analgesic for mild to moderate pain. I know from my own experience that my patients often receive very good pain relief from plain old Tylenol, sometimes when other pain medications have failed.
Citation, please? Double-blind studies have long-ago proven that acetaminophen is an effective pain-reliever against placebo. If you have definitive proof to the contrary, I'd be very interested.
Hospitals don't "proscribe" Tylenol for anything except perhaps liver failure patients. You probably meant "prescribe." And actually, hospitals don't prescribe a damn thing. The doctors still do that in my country.
1) a well-documented violation of the license
2) from a well-respected project
3) by a less-than-quadrillian-dollar/year company that
4) openly admitted to the violation.
My guess is that the FSF is advising the XviD folks to take it to court and nail Sigma to the wall with a big iron spike through the heart. They won't get a better chance than this to prove the GPL.
That helps by actually getting money to worthy artists. This isn't all about screwing the RIAA, you know. I still buy CD's from indepedent labels, but at least I know they're more likely to be getting a decent share of the money that way. For those enslaved by RIAA labels, there's always Musiclink, for when you do feel like screwing the RIAA as well as paying the artists.
The RIAA member labels can be found here. Don't buy music from them. There are plenty of good independent labels with good artists that deserve your money. Don't give it to those RIAA shills.
Screw having a talking dog, I want a superintelligent, telepathic dog that can help me get chicks...
Somebody mod the parent up as "funny."
Funny, a friend and I had the same impulse in college. Both of us ended up on the fencing team. I eventually ended up as team captain, and we won four straight conference titles.
Oh, crap. Let's see:
1) it's from Microsoft,
2) it's got literally tons and tons of bugs.
Obvious conclusion:
We're all dead because it's bound to crash!
Asimov did not coin the term "robot." He did however coin the term "robotics" to describe the study and creation of robots. Asimov goes into the etymology of the word "robot" somewhere in one of his bazillion books' forwards, I think.
IIRC, Cage of Freedom was not done by Adam Ant, but by Jon Anderson, long-time lead singer for Yes.
What would be really remarkable for UTD is if they could score Carmack to teach a class since he's also in the Dallas area, though a somewhat longer drive from the Mesquite offices of id Software. There isn't any question which class would be in higher demand, is there?
I just finished watching ANH recently, and something odd occurred to me. I can buy Lucas' contention that the 'droids' memories were wiped prior to ANH, but that doesn't account for the fact that Ben Kenobi seems not to recognize the droids at all when they find him in the Tatooine desert. This is despite the fact that he spent some very pivotal moments in galactic history with those two. Is Lucas going to alter Episode IV to make up for this apparent gaffe as well?
I agree that you can't get a decent image from the tv out of most video cards. However, most of us who are using htpc's primarily aren't using the crappy composite or s-video outputs. Personallly I'm using the vga output from the card to drive a front projection tv, which delivers an excellent picture. A visit over to the htpc forums at avsforums will find lots of people doing the same or similar.