This has the potential of being just the nightmare people were trying to avoid with a comany that claims to 'first, do no evil'. While I'm glad that they are resisting the subpoena just on the grounds that it's an invasion of privacy, if google looses this one, there is the potential that entire search histories could be tied back to the user (including the age AND name, in contrast to some of the earlier posts suggesting they would never get any useful demographic information). If you have a gmail account, and you 're signed in, google is keeping tabs on your specific search history.
I actually still hold on to the (perhaps naive) feeling that google's heart is in the right place for the most part, though seeing the billions of dollars in cash might sway things a little. If google loses though, millions of people's search histories, and perhaps, depending on the wording of the subpoena, demographics, if not names along with them.
I think you're missing the point. It's really a matter of symmantics, but genes are the strings of sequences which make a protein (there are other functions, but for the moment, we'll just stick with those). Genes coding for proteins (which is what most people consider the definition of genes, though there are a lot of small regulatory genes which are an entire PhD thesis in and of themselves) for the most part all serve an additive effect. There aren't a lot of genes I would rather not have (a lot are absolutely critical). The diseases you describe aren't caused by 'disease genes', but normal genes which, in the affected people have a mutation or defect causing the gene (which everyone has) to be structurally different or be expressed differently.
Genes are extremely complicated. There's a lot of things that need to go right for a string of DNA to show up, code for a protein, and express (get turned in to RNA, and eventually protein). This really only happens once in a evolutionary blue moon. I believe that what the original poster was trying to explain.
As someone working in the genomics and molecular biology field, I have to say that it's been an amazing ride over the past 6 or 7 years, since the human genome project really kicked in to full gear, the HapMap project took off, the National Cancer Institute's Cancer Genome Project, and comparative sequencing of countless genomes has and will be done.
I have to say though that the HapMap project is only a transient step to where this is all going. The NIH, NSF, and DOE are throwing significant amounts ofmoney incubating technologies to get us to the infamous '1000 dollar genome'. That's where things become really interesting.
The problem with HapMap, and frankly, the whole human genome project is that it's done on average people from diverse populations. Adults from diverse populations. Living Adults. What we all really want to know is what causes disease, and sequencing healthy people isn't going to completely get us there. There is a theory that common diseases are caused by large numbers of common varients or SNPs working in concert. In that respect, you can learn agood amount about things shuch as heart disease, certain psychiatric disorders, and cancers, but again, the SNPs most likely to be uncovered are those which have no deleterious effect.
Additionally, research using SNPs to find regions of interest on chromosomes (association or LD studies) require hundreds of thousands of data points in tens of thousands of people with disease and carefully paired controls. While the technology is there to do such projects now, it certainly isn't cheap. At some point, when technology allows, it will be way easier to just sequence the whole thing and look at the truely causitive SNPs and not the nearby SNPs with no biological relevance (which is what generally happens in association or LD studies- thus the name association, since they're associated, but not neccessarily the cause).
I certainly don't want to diminish the importance of the HapMap, as it is something that we could only dream of 10 years ago, and it will have a massive effect on medicine over the next 10 years, but the future is going to be absolutely incredible. At some point people will have themselves sequenced and have a comprehensive understanding of their suceptibilities for less than the cost of the prenatal screenings currently done on most newborns in the western world currently.
2. Sony will CONTACT YOU to tell you how to circumvent it
3. Sony WILL get bent when this ends up on the internet etc...
4. RIAA lawsuits ensue.
IANAL, but the problem here is that if the content provider tells you intentionally how to break the copy protection, they're inducing you to violate their IP. It's the digital equivalent of a cop approaching you, handing you a joint and saying, "Don't worry. I'm not going to arrest you if you smoke this", then arresting the person. It's essentially entrapment (though it's civil rather than criminal)
I was able to hack my WinXP box to run linux by using a second hard drive. It was actually quite easy.
1. Pull out the hard drive with WinXP (you should probably do this with the power off, but it's more fun with the power on)
2. Plug in a fresh new hard drive
3. Put in your Fedora install CDs and follow the prompts
4. Play homebrew linux apps on your hacked box (Profit!)
The best part is that if you ever need to use WinXP again, all you need to do is turn it off and swap the hard drives.
I realize this is merely a swap hack, but it's a start. Someday, I hope to be able to make it so I don't need to be pulling hard drives, but that could take til like 1995. We'll see
If your home gets compromised, it really doesn't matter all that much whether you have your password written down. Keep in mind that most wireless routers have a reset button which knocks it back to the factory defaults (including password).
A significant number of companies have pulled such manuvers. On paper all it takes is some cash and some serious balls. The problem is if you manage to pull off a leveraged buyout, you end up with a ton of debt.
According to yahoo finance, SUNW has about 3.15 billion in cash (some of those other assets in the 7.5billion mentioned above are going to be hard to sell. They may be decent collatoral for a loan, but they don't, in and of themselves, free up cash), and 1.12b in long term debt. If they buy at 5.50 (which is probably as low as they could possibly pull it off for) the price would be 18.5b. This would leave them with 16 or so billion in debt.
Interest on this alone would be about 800 million per year, wiping out all of this year's real (not EBITDA) earnings.
The only way to solve that issue is to sell assets, cut costs (including labor) and cross your fingers. Sun would definitely be a miserable place to work for some time to come.
For anyone that's interested, the book 'Barbarians at the Gate' is a great read on the subject, following all of the players in the leveraged buyout of RJ Reynolds in the late 80s.
The only thing I would point out is that you mentioned that 99% of the people who BUY the DVD and would need to break the encoding have legit uses in mind.
There's a ton of people out there who never buy the content to begin with, because they download it themselves.
There's a huge difference. I know that the Betamax defense is the obvious counterargument, but that was way before one could make indefinite copies without massive quality loss. The idea that one would make really good copies available to a massive amouont of people wasn't covered in that case.
Best thing from that page is the video where they place 4 lbs of thermite on top of a disk drive and ignite it. 3000 degrees does wonders to a hard drive.
The link is mid page on the right. I think it's video part 2
I can't understand why they would only launch in 40 cities instead of nationwide (or worldwide). I've got vonage, and when I signed up, I got to pick phone numbers from essentially anywhere in N. America, so really, where the customer is located doesn't matter.
For what it's worth, my vonage line is my home office line, so I've even been known to travel with it when I want to work from my college friend's house. Just plug it in to their cable modem, then plug it in to a phone. Ultimate portability.
Sweet. I hope this is a trend. I'm going to sit at my computer all day tomorrow and tick off the seconds until I get a shot at being the first to make some witty comment about Bill Gates' Lexus, maybe crap on the cost of Mac upgrades, and maybe, just maybe, I can be quick enough to get first post on day 3 of the XM / Sirius merger rumor.
I can understand wanting to encourage competition, but DirecTV and Dish already have some stiff competition from Cable. I really don't see this fundamentally changing that landscape. What does change though is that you would only have one provider of sattelite radio. In the end, I think there's a net negative effect on competition if this were to go through.
The one thing that I think would be really cool, but I'm not sure of the feasability of, would be to eliminate the need for a perfectly aimed dish for sattelite TV. I live in an area where it's impossible to get good line of sight for DirecTV. Does anyone know whether Sirius / XM could alleviate this problem, since apparently the radios can be used indoors? I know radio is a lot less bandwith, but I'm not sure whether that is the issue, or perhaps they use different frequencies, or possibly just have stronger signal strength.
I wonder whether this will be branded as an Apple phone or as a Motorola phone. Seeing as Motorola's marketing gusto seemed to die with the Star-Tac, I'm personally rooting for an Apple phone.
Slashdot Mirror
I actually still hold on to the (perhaps naive) feeling that google's heart is in the right place for the most part, though seeing the billions of dollars in cash might sway things a little. If google loses though, millions of people's search histories, and perhaps, depending on the wording of the subpoena, demographics, if not names along with them.
Genes are extremely complicated. There's a lot of things that need to go right for a string of DNA to show up, code for a protein, and express (get turned in to RNA, and eventually protein). This really only happens once in a evolutionary blue moon. I believe that what the original poster was trying to explain.
I have to say though that the HapMap project is only a transient step to where this is all going. The NIH, NSF, and DOE are throwing significant amounts ofmoney incubating technologies to get us to the infamous '1000 dollar genome'. That's where things become really interesting.
The problem with HapMap, and frankly, the whole human genome project is that it's done on average people from diverse populations. Adults from diverse populations. Living Adults. What we all really want to know is what causes disease, and sequencing healthy people isn't going to completely get us there. There is a theory that common diseases are caused by large numbers of common varients or SNPs working in concert. In that respect, you can learn agood amount about things shuch as heart disease, certain psychiatric disorders, and cancers, but again, the SNPs most likely to be uncovered are those which have no deleterious effect.
Additionally, research using SNPs to find regions of interest on chromosomes (association or LD studies) require hundreds of thousands of data points in tens of thousands of people with disease and carefully paired controls. While the technology is there to do such projects now, it certainly isn't cheap. At some point, when technology allows, it will be way easier to just sequence the whole thing and look at the truely causitive SNPs and not the nearby SNPs with no biological relevance (which is what generally happens in association or LD studies- thus the name association, since they're associated, but not neccessarily the cause).
I certainly don't want to diminish the importance of the HapMap, as it is something that we could only dream of 10 years ago, and it will have a massive effect on medicine over the next 10 years, but the future is going to be absolutely incredible. At some point people will have themselves sequenced and have a comprehensive understanding of their suceptibilities for less than the cost of the prenatal screenings currently done on most newborns in the western world currently.
2. Sony will CONTACT YOU to tell you how to circumvent it
3. Sony WILL get bent when this ends up on the internet etc...
4. RIAA lawsuits ensue.
IANAL, but the problem here is that if the content provider tells you intentionally how to break the copy protection, they're inducing you to violate their IP. It's the digital equivalent of a cop approaching you, handing you a joint and saying, "Don't worry. I'm not going to arrest you if you smoke this", then arresting the person. It's essentially entrapment (though it's civil rather than criminal)
1. Pull out the hard drive with WinXP (you should probably do this with the power off, but it's more fun with the power on)
2. Plug in a fresh new hard drive
3. Put in your Fedora install CDs and follow the prompts
4. Play homebrew linux apps on your hacked box (Profit!)
The best part is that if you ever need to use WinXP again, all you need to do is turn it off and swap the hard drives.
I realize this is merely a swap hack, but it's a start. Someday, I hope to be able to make it so I don't need to be pulling hard drives, but that could take til like 1995. We'll see
I wouldn't bank on it unless Steve Jobs issues the tsunami warning himself.
And to think I thought Marx generators only transferred energy from the bourgeoisie to the proletariat...
This put's the Flux Capacitor to shame. No where did I park that Delorean?
If your home gets compromised, it really doesn't matter all that much whether you have your password written down. Keep in mind that most wireless routers have a reset button which knocks it back to the factory defaults (including password).
According to yahoo finance, SUNW has about 3.15 billion in cash (some of those other assets in the 7.5billion mentioned above are going to be hard to sell. They may be decent collatoral for a loan, but they don't, in and of themselves, free up cash), and 1.12b in long term debt. If they buy at 5.50 (which is probably as low as they could possibly pull it off for) the price would be 18.5b. This would leave them with 16 or so billion in debt.
Interest on this alone would be about 800 million per year, wiping out all of this year's real (not EBITDA) earnings.
The only way to solve that issue is to sell assets, cut costs (including labor) and cross your fingers. Sun would definitely be a miserable place to work for some time to come.
For anyone that's interested, the book 'Barbarians at the Gate' is a great read on the subject, following all of the players in the leveraged buyout of RJ Reynolds in the late 80s.
There's a ton of people out there who never buy the content to begin with, because they download it themselves.
There's a huge difference. I know that the Betamax defense is the obvious counterargument, but that was way before one could make indefinite copies without massive quality loss. The idea that one would make really good copies available to a massive amouont of people wasn't covered in that case.
The link is mid page on the right. I think it's video part 2
For what it's worth, my vonage line is my home office line, so I've even been known to travel with it when I want to work from my college friend's house. Just plug it in to their cable modem, then plug it in to a phone. Ultimate portability.
Are still wating for the 12 sided die...Oh, wait...
FYI the top 500 supercomputers list is maintained at http://www.top500.org/.
My rule is if they can't beat me in a sales call, I won't even consider it.
No more mucking around trying to get that gas stove to just the right temperature!
After all Cocaine wants to be free too.
Sit Ubu sit... Good dog.
Pedro offers you his protection
Sweet. I hope this is a trend. I'm going to sit at my computer all day tomorrow and tick off the seconds until I get a shot at being the first to make some witty comment about Bill Gates' Lexus, maybe crap on the cost of Mac upgrades, and maybe, just maybe, I can be quick enough to get first post on day 3 of the XM / Sirius merger rumor.
The one thing that I think would be really cool, but I'm not sure of the feasability of, would be to eliminate the need for a perfectly aimed dish for sattelite TV. I live in an area where it's impossible to get good line of sight for DirecTV. Does anyone know whether Sirius / XM could alleviate this problem, since apparently the radios can be used indoors? I know radio is a lot less bandwith, but I'm not sure whether that is the issue, or perhaps they use different frequencies, or possibly just have stronger signal strength.
imagine a beowolf cluster of these
Hmmm.... iTones maybe?
I wonder whether this will be branded as an Apple phone or as a Motorola phone. Seeing as Motorola's marketing gusto seemed to die with the Star-Tac, I'm personally rooting for an Apple phone.