no one forced him to buy a remote with 52 buttons, altho it is true that for many items you can't buy simple things
the example of an oven (what the hell is a hobb ?) - a very few people, like S Jobs, are willing to try and fail with new things; most manufactureres are scared to death to do anything different, cause it might lead to a downturn in sales I agree, the linear relation of knobs is bad, and every year probably leads to a few burns when the wrong burner gets turned on - so why no improvement maybe, the free market needs some guidance or nudge or push from govt (gasp !!)
people who make stuff are stupid: Sturgeon's rule: the american sci fi writer T Sturgeon was asked why most sci fi writing is so bad, and he said, 99% of everything is BS - in this case, a lot of the people making this stuff are stupid
Consumers put up with it - do you see people rebelling ? major rebellions are rare; i remember the 80s, when the fashion world tried to sell miniskirts for buisness clothing; the fashion industry righlty lost huge sums of money.
Consumers don't like change (/.ers are not normal) - go into any store that sells standard sutff like appliances and anything new will languish, or be a special high priced niche item. there are of course a lot of exceptions, but this is a good general rule.
It is not that easy to just say, try something different - unless you have tried, don't be glib and say something that sounds easy like bring in people who are not trained
it is exspensive to it different; people constantly demand the lowest price, which means you need super high volume of manufacture and you can't spend money to do redesign
you make money by margin (RATIO sales/cost) so there is tremendous pressure to get the consumer to buy higher priced feature laden stuff; I am sure that all/.ers are aware that GM and ford make a LOT more money from large SUVs and luxury cares, on both an absolute and percent basis, then from, say, a malibu or taurus. If you make 5 bucks on a 52 button control, and 1 buck on a 10 button control, what you gonna sell ? of course, you can come up with a million counter examples, but these are some good guides.
sellers make more money by bundling wanted features with unwanted (packages on autos anyone ?)
There is a very, very, very simple solution: just don't buy it It worked with beta/vhs - consumers got one format, and it will probably work with HD/blueray don't like complicated stuff, just don't buy it
I think you have missed several points when you claim there is a funding crisis. First, what is the right amount of money to spend on research, for, say, incurable pancreatic cancer ? Do we measure it by % of GDP, do we measure it by dollars on cancer/dollars on Iraq ? Untill we have some consensus, research will always be "underfunded" Second, the basic structure of NIH funded reasearch ENSURES that there will always be a "funding crisis", because the increase in funding will always lag the increase in scientists - a classic malthusian argument. lets assume Govt funds increase each year at, say 10%, maybe 5% a year after inflation. However, the number of scientists increases exponentially - as follows. Govt grants (R01 in the jargon) are awarded, legally, to a principal investigator at some sort of institution -say a prof at a university. Each PI is on a treadmill: do research to publish papers to get more grants to... The easiest way to do research is graduate students - they are cheap and hardworking. so you hire as many grad students as you can, and although many will drop out or go to industry or other professions, some will become PIs of their own, and start the whole process over. It takes 5-8 years from college graduation to becoming a PI; one PI can train 5 or 6 or even more students at a time. It should be clear to/. readers that under almost any math scenario, the number of PIs will increase faster then the funding, and that this increase has a "doubling time" which means things look fine untill they suddenly crash. OF course, this process requires job slots at universitys - who could cooperate and limit the number of jobs, but since RnD jobs add prestige and salary to univ deans and presidents, univeristy build the max number of buildings they can, so they can fill them ith profs....
Several posters have noted that prior to clinton, we had a funding crisis, and the nih budget was doubled, and all the universitys went and built HUGE new buildings, and greatly increased the number of NIH supported scientists.... untill these structural issues are solved, we will always have a funding crisis. I also believe that good scientists are very rare, and they need and require long term support, another thing that is hard.
this supposedly novel property , which can be obtained with the right sort of weaving
reminds me of a story about a famous mathemetician, who after watching his wife knit, goes and thinks for a while, and comes back and says to her, I have mathematically deduced anothe way of knitting....it's called perling dear.. moral is, I bet lots of weavers have known about this for a long time,
I bet if you go back into "ancient" history, like 1995, you will find similar statemts for every major release from MS Might even be amusing to collect such comments, as an illustration of the famous saying that those who ignore history are condemmed to repeat it In any event, this sort of thing Hasn't seemed to hurt MS
firefox coulda woulda shoulda been the ie killer: i personally have turned, what 20 people onto ff, and routinely used to write letters to the contact us/webmaster link at websites, complaining of poor ff compatibility
No more - all that money from google, they pay their ceo more then they spend on RnD, F*ck fire fox and Mozilla, I won't do a damm thing for em anymore
In the article, they note that rapid prototyping is simpler, more usefull and general tool, but that rapid prototyping machines cause upward of 50K www.desktopfactory.com
these 3D printers - printers that print a layer of plastic, then another layer to make a solid 3 dimensional object - are just like other super high vol hardware: if it costs 5K this year, you will get 2X the performance for half the price next year - in 15 years, kids will come home from school and complain that there is no resin for the 3D pritner for their 5th grade social studies project, cause they need to make a 3D, realistic scaled model of , say an Aztec building (my kids are studying aztecs right now)
whitesides (i think) was the first guy to go cheap by printing masks with consumer level printers, and making cheap masters for pdms molds perhaps someone else can give a good summary and comparision
sounds like there is a business selling physically destructable drives - a drive witha an easy open case, and a method to physcially damage the platter
when i was a kid, an older geek guy told me, with admiration in his voice, about collins radio, and the manual that went with its equpiment for the military. the 1st page of hte manual said something to the effect, if this equipment is about to be captured by the enemey, here is one thing you can do in 1 min to render the equiment unusable....
because religion is, basically, silly - like taking the tooth fairy seriously. So, the religious have resort to arguments that are alogical, like believe or i will kill you, or, since I don't understand it, it must be the majesty of god. So, everytime science gives something an explanation, the argument that god exists cause we dont understand something is reduced a little. That is why the religious are aways against science - cause it always reduces the range of "fantastical" things they can point to as unexlained, and therefore evidence of a diety. (BTW, the fact that someone can believe in silly nonsense (religion) and be a good person or a good scientist just shows that humans are complex, not simple )
your brain in a computer = immortality and any sensation any time Since "you" = "your brain" = electrical and chemical reactions that can be fully modeled in a computer there is no difference between you and your model in the computer (there is a slight difference in that sensory inputs are done electrically, instead of a mix of electric and chemical0 to put it another way, if the hardware fully models your brain, is there any difference to you ? your personality is the same and your sensory inputs can be anythying you want at any time - if your brain is in a computer your eyes are seeing the most gorgeous memeber of the opp sex ever all the time....
This sort of removes the need for medicine
A total totalitatrian state i assume many/.s have seen the movie dune, where on the planet geidi prime the evil ruler, baron harkonnen has a heart plug installed in every one - one quick tug of the string and all your blood pours out If you extrapolate from current technology, you could implant every person with 24/7 gps rfid and sound and maybe even sight so you could know where every single person is, what they hear and what they see 24/7 - you could also implant shockers, so you could shock anyone who utters the words "bush" and "moron" within 5 seconds of each other
Computers smarter then us - an old one, we become their servants - surely someone on/. must have a rough estimate of the computing power of the human brain, and how far from that we are in current hardware/software
how about locking overnight cleaning crews in the store, so they can't get out how about all the sex discrminationn law suits how about no health insurance, while the walton family has close to a 100 billion in stock how about all the mom and pops with small stores who don't have a decent retirement cause wal mart destroyed them how about the damage to our environment due to a car based store model(this is a little to sophisticted for/., you don't have to reply how about...and that is just off the top of my head, without even trying
like any major corporation, walmart is bad because major corporations care only about profit; it is in their dna, they can't help it - any large corporation would bid on zyklon if it was profitable, that iswhy we have goverment, to help protect us from large corporations the 15 scariest words int eh english language - we are a large company, and there is no govt regultor loooking over our sholder
anyone care to calculate the ratio of lead and halogens in intels world output to lead acid car batterys or american's swimming pools ? talk about BS (swimming pools use large amounts of that well known halogen, chlorine)
assuming you are both right on the basic facts, why is there such a large disrepcancy in price ? For instance, the 3M cost - if we don't know what margin GE or Siemens is getting, we don't know how realistic that price is - maybe it only costs GE 500K to actually build the machine, so they could, if they wanted, sell it for 1 M...
Or maybe india has a second hand, but still fully usable machine (your center -where did your last machine go ?)
I don't know what the cost of 5oK refridgeration is, but i do know that liquid nitrogen is awfully cheap.
from the abstract ( http://www.jbc.org/cgi/content/abstract/282/45/32844 ) On a mouse treadmill, PEPCK-Cmus mice ran up to 6 km at a speed of 20 m/min, whereas controls stopped at 0.2 km. 6 Km vs 0.2 - thats a big difference !! PEPCK-Cmus mice had an enhanced exercise capacity, with a VO2max of 156 ± 8.0 ml/kg/min, a maximal respiratory exchange ratio of 0.91 ± 0.03, and blood lactate of 3.7 ± 1.0 mM after running for 32 min at a 25 grade control animals were 112 ± 21 ml/kg/min, 0.99 ± 0.08, and 8.1 ± 5.0 mM respectively. The PEPCK-Cmus mice ate 60% more than controls but had half the body weight and 10% the body fat as determined by magnetic resonance imaging.
I was recently diagnosed with type 2 I went on a crash diet exercise program; it is hlping, don't know if it will cure me yet, but hoping I talked to my doctor, and he said, you would be amazed at how many 300+ pound people get your diagnosis and ask for a pill
Now if it is true, as pointed out, that type II diabetes is unkown in "poorer" countrys,You could say people in the USA are lazy gluttinous slobs who just want a pill, but people are human: many of us really cna't handle the surfiet of food available in the us
Today I got donuts for the group (friday) at dunkin donuts here in boston you can get 12 dountus - virtually all fat and sugar, enoiugh calorys for a week, for less then 6 bucks !!! Many of us just have a lot of problems with this. If you look around at suff like aircraft, or medical devices, or any industry where safety is thought about, the number 1 rule is design so it can't happen applying this, what is most important is increasing the cost or decreasing the availability of junk food and getting people out of their automobiles and walking
5 gets you 10, there are dozens of posts abouthow gimp doesn't have necessary features in photoshoop. instead of the usual/. flamewars, how about all the people who say gimp must have feature x to compete get together and make a list... naw, that would make to much sense
why are the posters editors so lazy they don't take the 15 seconds it took me to provide decent citation information this sort of lazyness infects the web and it is BAD at least now you have enough info to track this story accurately
Amyloid beta oligomers induce impairment of neuronal insulin receptors Wei-Qin Zhao, Fernanda G. De Felice, Sara Fernandez, Hui Chen, Mary P. Lambert, Michael J. Quon, Grant A. Krafft, and William L. Klein
E-mail contact: wei-qin_zhao@northwestern.edu
Recent studies have indicated an association between Alzheimer's disease (AD) and central nervous system (CNS) insulin resistance. However, the cellular mechanisms underlying the link between these two pathologies have not been elucidated. Here we show that signal transduction by neuronal insulin receptors (IR) is strikingly sensitive to disruption by soluble A{beta} oligomers (also known as ADDLs). ADDLs are known to accumulate in AD brain and have recently been implicated as primary candidates for initiating deterioration of synapse function, composition, and structure. Using mature cultures of hippocampal neurons, a preferred model for studies of synaptic cell biology, we found that ADDLs caused a rapid and substantial loss of neuronal surface IRs specifically on dendrites bound by ADDLs. Removal of dendritic IRs was associated with increased receptor immunoreactivity in the cell body, indicating redistribution of the receptors. The neuronal response to insulin, measured by evoked IR tyrosine autophosphorylation, was greatly inhibited by ADDLs. Inhibition also was seen with added glutamate or potassium-induced depolarization. The effects on IR function were completely blocked by NMDA receptor antagonists, tetrodotoxin, and calcium chelator BAPTA-AM. Downstream from the IR, ADDLs induced a phosphorylation of Akt at serine473, a modification associated with neurodegenerative and insulin resistance diseases. These results identify novel factors that affect neuronal IR signaling and suggest that insulin resistance in AD brain is a response to ADDLs, which disrupt insulin signaling and may cause a brain-specific form of diabetes as part of an overall pathogenic impact on CNS synapses.--Zhao, W. Q., De Felice, F. G., Fernandez, S., Chen, H., Lambert, M. P., Quon, M. J., Krafft, G. A., Klein, W. L. Amyloid beta oligomers induce impairment of neuronal insulin receptors.
this has got to be the best post on/. re linux vs ms in the last two year simple elegant in the real world
it brings up another point: if the software is freee then walmart and best buy make more money rebranding linux with their in house support - if you were CFO of walmart, I bet you would loveyour own linux that you can charge warranty/service for , like geek squad at best buy
thier is just one small problem: for most people linux doesnt work, in the sense of not having codecs, not having wireless etc etc fix that an MS is dead
only to those who own it (Ben Franklin: Freedom of the press belongs only to those who own one)
The obvious , practical solution is for someone to create some sort of "open" community owned ISP. Until that is done, corporations like ATnT will behave according to thier DNA: profits before all else; complaining about that is like complaining that piranhas are vicious
Is their a group that can put together a community open source isp ?, perhpas using some sort of next gen wimax, you need a super router every mile or so ? (just speculating there)
There is something mis leading about the story - how can it take much longer in a lab, other then the transport time ? The lab can, due to its higher volume, have a large, automated system; such systems, at least in clinical diagnostics (roche, abbott, dade behring immunoassays) quicker and more reliable then poc (point of care ) systems.
Re the accuracy, the basic idea is fine, but the devil is in the details - for instance, pcr based systems are notorious for cross contamination; if even a micro micro drop of the post pcr material contaminates anything, you have real problems. The photo in the article shows someone with handheld pipets (the grey thing in the ladys hand) such pipets are notorious for aerosol production, which leads to cross contamination
Slashdot Mirror
no one forced him to buy a remote with 52 buttons, altho it is true that for many items you can't buy simple things
/.ers are aware that GM and ford make a LOT more money from large SUVs and luxury cares, on both an absolute and percent basis, then from, say, a malibu or taurus.
the example of an oven (what the hell is a hobb ?) - a very few people, like S Jobs, are willing to try and fail with new things; most manufactureres are scared to death to do anything different, cause it might lead to a downturn in sales
I agree, the linear relation of knobs is bad, and every year probably leads to a few burns when the wrong burner gets turned on - so why no improvement
maybe, the free market needs some guidance or nudge or push from govt (gasp !!)
people who make stuff are stupid: Sturgeon's rule: the american sci fi writer T Sturgeon was asked why most sci fi writing is so bad, and he said, 99% of everything is BS - in this case, a lot of the people making this stuff are stupid
Consumers put up with it - do you see people rebelling ? major rebellions are rare; i remember the 80s, when the fashion world tried to sell miniskirts for buisness clothing; the fashion industry righlty lost huge sums of money.
Consumers don't like change (/.ers are not normal) - go into any store that sells standard sutff like appliances and anything new will languish, or be a special high priced niche item. there are of course a lot of exceptions, but this is a good general rule.
It is not that easy to just say, try something different - unless you have tried, don't be glib and say something that sounds easy like bring in people who are not trained
it is exspensive to it different; people constantly demand the lowest price, which means you need super high volume of manufacture and you can't spend money to do redesign
you make money by margin (RATIO sales/cost) so there is tremendous pressure to get the consumer to buy higher priced feature laden stuff; I am sure that all
If you make 5 bucks on a 52 button control, and 1 buck on a 10 button control, what you gonna sell ?
of course, you can come up with a million counter examples, but these are some good guides.
sellers make more money by bundling wanted features with unwanted (packages on autos anyone ?)
There is a very, very, very simple solution: just don't buy it
It worked with beta/vhs - consumers got one format, and it will probably work with HD/blueray
don't like complicated stuff, just don't buy it
I think you have missed several points when you claim there is a funding crisis. /. readers that under almost any math scenario, the number of PIs will increase faster then the funding, and that this increase has a "doubling time" which means things look fine untill they suddenly crash.
First, what is the right amount of money to spend on research, for, say, incurable pancreatic cancer ? Do we measure it by % of GDP, do we measure it by dollars on cancer/dollars on Iraq ? Untill we have some consensus, research will always be "underfunded"
Second, the basic structure of NIH funded reasearch ENSURES that there will always be a "funding crisis", because the increase in funding will always lag the increase in scientists - a classic malthusian argument.
lets assume Govt funds increase each year at, say 10%, maybe 5% a year after inflation.
However, the number of scientists increases exponentially - as follows. Govt grants (R01 in the jargon) are awarded, legally, to a principal investigator at some sort of institution -say a prof at a university. Each PI is on a treadmill: do research to publish papers to get more grants to... The easiest way to do research is graduate students - they are cheap and hardworking. so you hire as many grad students as you can, and although many will drop out or go to industry or other professions, some will become PIs of their own, and start the whole process over. It takes 5-8 years from college graduation to becoming a PI; one PI can train 5 or 6 or even more students at a time.
It should be clear to
OF course, this process requires job slots at universitys - who could cooperate and limit the number of jobs, but since RnD jobs add prestige and salary to univ deans and presidents, univeristy build the max number of buildings they can, so they can fill them ith profs....
Several posters have noted that prior to clinton, we had a funding crisis, and the nih budget was doubled, and all the universitys went and built HUGE new buildings, and greatly increased the number of NIH supported scientists....
untill these structural issues are solved, we will always have a funding crisis.
I also believe that good scientists are very rare, and they need and require long term support, another thing that is hard.
would that/. had more like this
this supposedly novel property , which can be obtained with the right sort of weaving
.. moral is, I bet lots of weavers have known about this for a long time,
reminds me of a story about a famous mathemetician, who after watching his wife knit, goes and thinks for a while, and comes back and says to her, I have mathematically deduced anothe way of knitting....it's called perling dear
i really don' understand your comment - can you explain a little more (seriously) I dont get it
I bet if you go back into "ancient" history, like 1995, you will find similar statemts for every major release from MS
Might even be amusing to collect such comments, as an illustration of the famous saying that those who ignore history are condemmed to repeat it
In any event, this sort of thing Hasn't seemed to hurt MS
firefox coulda woulda shoulda been the ie killer: i personally have turned, what 20 people onto ff, and routinely used to write letters to the contact us/webmaster link at websites, complaining of poor ff compatibility
No more - all that money from google, they pay their ceo more then they spend on RnD, F*ck fire fox and Mozilla, I won't do a damm thing for em anymore
In the article, they note that rapid prototyping is simpler, more usefull and general tool, but that rapid prototyping machines cause upward of 50K
www.desktopfactory.com
these 3D printers - printers that print a layer of plastic, then another layer to make a solid 3 dimensional object - are just like other super high vol hardware: if it costs 5K this year, you will get 2X the performance for half the price next year - in 15 years, kids will come home from school and complain that there is no resin for the 3D pritner for their 5th grade social studies project, cause they need to make a 3D, realistic scaled model of , say an Aztec building (my kids are studying aztecs right now)
whitesides (i think) was the first guy to go cheap by printing masks with consumer level printers, and making cheap masters for pdms molds
perhaps someone else can give a good summary and comparision
just 5 seconds on google turned up this http://www.desktopfactory.com/contact_us/
twice the price, but looks like 5x the perfomance
what i was going to post...I am a comcast customer, and could have fios, but I don't care about any thing that is different, so why bother ?
i guess the question is how are you sure - like in bet a months salary sure ?
software methods always leave a doubt
shredding the platter seems sure
sounds like there is a business selling physically destructable drives - a drive witha an easy open case, and a method to physcially damage the platter
when i was a kid, an older geek guy told me, with admiration in his voice, about collins radio, and the manual that went with its equpiment for the military.
the 1st page of hte manual said something to the effect, if this equipment is about to be captured by the enemey, here is one thing you can do in 1 min to render the equiment unusable....
because religion is, basically, silly - like taking the tooth fairy seriously. So, the religious have resort to arguments that are alogical, like believe or i will kill you, or, since I don't understand it, it must be the majesty of god.
So, everytime science gives something an explanation, the argument that god exists cause we dont understand something is reduced a little. That is why the religious are aways against science - cause it always reduces the range of "fantastical" things they can point to as unexlained, and therefore evidence of a diety.
(BTW, the fact that someone can believe in silly nonsense (religion) and be a good person or a good scientist just shows that humans are complex, not simple )
your brain in a computer = immortality and any sensation any time
/.s have seen the movie dune, where on the planet geidi prime the evil ruler, baron harkonnen has a heart plug installed in every one - one quick tug of the string and all your blood pours out
/. must have a rough estimate of the computing power of the human brain, and how far from that we are in current hardware/software
Since "you" = "your brain" = electrical and chemical reactions that can be fully modeled in a computer there is no difference between you and your model in the computer (there is a slight difference in that sensory inputs are done electrically, instead of a mix of electric and chemical0
to put it another way, if the hardware fully models your brain, is there any difference to you ? your personality is the same and your sensory inputs can be anythying you want at any time - if your brain is in a computer your eyes are seeing the most gorgeous memeber of the opp sex ever all the time....
This sort of removes the need for medicine
A total totalitatrian state
i assume many
If you extrapolate from current technology, you could implant every person with 24/7 gps rfid and sound and maybe even sight so you could know where every single person is, what they hear and what they see 24/7 - you could also implant shockers, so you could shock anyone who utters the words "bush" and "moron" within 5 seconds of each other
Computers smarter then us - an old one, we become their servants - surely someone on
how about locking overnight cleaning crews in the store, so they can't get out /., you don't have to reply
how about all the sex discrminationn law suits
how about no health insurance, while the walton family has close to a 100 billion in stock
how about all the mom and pops with small stores who don't have a decent retirement cause wal mart destroyed them
how about the damage to our environment due to a car based store model(this is a little to sophisticted for
how about...and that is just off the top of my head, without even trying
like any major corporation, walmart is bad because major corporations care only about profit; it is in their dna, they can't help it - any large corporation would bid on zyklon if it was profitable, that iswhy we have goverment, to help protect us from large corporations
the 15 scariest words int eh english language - we are a large company, and there is no govt regultor loooking over our sholder
anyone care to calculate the ratio of lead and halogens in intels world output to lead acid car batterys or american's swimming pools ?
talk about BS
(swimming pools use large amounts of that well known halogen, chlorine)
assuming you are both right on the basic facts, why is there such a large disrepcancy in price ?
For instance, the 3M cost - if we don't know what margin GE or Siemens is getting, we don't know how realistic that price is - maybe it only costs GE 500K to actually build the machine, so they could, if they wanted, sell it for 1 M...
Or maybe india has a second hand, but still fully usable machine (your center -where did your last machine go ?)
I don't know what the cost of 5oK refridgeration is, but i do know that liquid nitrogen is awfully cheap.
from the abstract ( http://www.jbc.org/cgi/content/abstract/282/45/32844 )
On a mouse treadmill,
PEPCK-Cmus mice ran up to 6 km at a speed of 20 m/min, whereas controls stopped at 0.2 km.
6 Km vs 0.2 - thats a big difference !!
PEPCK-Cmus mice had an enhanced exercise capacity, with a VO2max of 156 ± 8.0 ml/kg/min, a maximal respiratory exchange ratio of 0.91 ± 0.03, and blood lactate of 3.7 ± 1.0 mM after running for 32 min at a 25 grade
control animals were 112 ± 21 ml/kg/min, 0.99 ± 0.08, and 8.1 ± 5.0 mM respectively.
The PEPCK-Cmus mice ate 60% more than controls but had half the body weight and 10% the body fat as determined by magnetic resonance imaging.
It's easy to understand infinity, just contemplate human stupidity
Variously attributed to Einstein, Pascal, and the suprevisor of stone cutting at the pyramids
I was recently diagnosed with type 2
I went on a crash diet exercise program; it is hlping, don't know if it will cure me yet, but hoping
I talked to my doctor, and he said, you would be amazed at how many 300+ pound people get your diagnosis and ask for a pill
Now if it is true, as pointed out, that type II diabetes is unkown in "poorer" countrys,You could say people in the USA are lazy gluttinous slobs who just want a pill,
but
people are human: many of us really cna't handle the surfiet of food available in the us
Today I got donuts for the group (friday) at dunkin donuts here in boston you can get 12 dountus - virtually all fat and sugar, enoiugh calorys for a week, for less then 6 bucks !!! Many of us just have a lot of problems with this.
If you look around at suff like aircraft, or medical devices, or any industry where safety is thought about, the number 1 rule is
design so it can't happen
applying this, what is most important is increasing the cost or decreasing the availability of junk food and getting people out of their automobiles and walking
5 gets you 10, there are dozens of posts abouthow gimp doesn't have necessary features in photoshoop. instead of the usual /. flamewars, how about all the people who say gimp must have feature x to compete get together and make a list...
naw, that would make to much sense
why are the posters editors so lazy they don't take the 15 seconds it took me to provide decent citation information this sort of lazyness infects the web and it is
BAD
at least now you have enough info to track this story accurately
Amyloid beta oligomers induce impairment of neuronal insulin receptors
Wei-Qin Zhao, Fernanda G. De Felice, Sara Fernandez, Hui Chen, Mary P. Lambert, Michael J. Quon, Grant A. Krafft, and William L. Klein
E-mail contact: wei-qin_zhao@northwestern.edu
Recent studies have indicated an association between Alzheimer's disease (AD) and central nervous system (CNS) insulin resistance. However, the cellular mechanisms underlying the link between these two pathologies have not been elucidated. Here we show that signal transduction by neuronal insulin receptors (IR) is strikingly sensitive to disruption by soluble A{beta} oligomers (also known as ADDLs). ADDLs are known to accumulate in AD brain and have recently been implicated as primary candidates for initiating deterioration of synapse function, composition, and structure. Using mature cultures of hippocampal neurons, a preferred model for studies of synaptic cell biology, we found that ADDLs caused a rapid and substantial loss of neuronal surface IRs specifically on dendrites bound by ADDLs. Removal of dendritic IRs was associated with increased receptor immunoreactivity in the cell body, indicating redistribution of the receptors. The neuronal response to insulin, measured by evoked IR tyrosine autophosphorylation, was greatly inhibited by ADDLs. Inhibition also was seen with added glutamate or potassium-induced depolarization. The effects on IR function were completely blocked by NMDA receptor antagonists, tetrodotoxin, and calcium chelator BAPTA-AM. Downstream from the IR, ADDLs induced a phosphorylation of Akt at serine473, a modification associated with neurodegenerative and insulin resistance diseases. These results identify novel factors that affect neuronal IR signaling and suggest that insulin resistance in AD brain is a response to ADDLs, which disrupt insulin signaling and may cause a brain-specific form of diabetes as part of an overall pathogenic impact on CNS synapses.--Zhao, W. Q., De Felice, F. G., Fernandez, S., Chen, H., Lambert, M. P., Quon, M. J., Krafft, G. A., Klein, W. L. Amyloid beta oligomers induce impairment of neuronal insulin receptors.
this has got to be the best post on /. re linux vs ms in the last two year
simple
elegant
in the real world
it brings up another point: if the software is freee then walmart and best buy make more money rebranding linux with their in house support - if you were CFO of walmart, I bet you would loveyour own linux that you can charge warranty/service for , like geek squad at best buy
thier is just one small problem: for most people linux doesnt work, in the sense of not having codecs, not having wireless etc etc
fix that an MS is dead
only to those who own it
(Ben Franklin: Freedom of the press belongs only to those who own one)
The obvious , practical solution is for someone to create some sort of "open" community owned ISP. Until that is done, corporations like ATnT will behave according to thier DNA: profits before all else; complaining about that is like complaining that piranhas are vicious
Is their a group that can put together a community open source isp ?, perhpas using some sort of next gen wimax, you need a super router every mile or so ? (just speculating there)
There is something mis leading about the story - how can it take much longer in a lab, other then the transport time ?
The lab can, due to its higher volume, have a large, automated system; such systems, at least in clinical diagnostics (roche, abbott, dade behring immunoassays) quicker and more reliable then poc (point of care ) systems.
Re the accuracy, the basic idea is fine, but the devil is in the details - for instance, pcr based systems are notorious for cross contamination; if even a micro micro drop of the post pcr material contaminates anything, you have real problems.
The photo in the article shows someone with handheld pipets (the grey thing in the ladys hand) such pipets are notorious for aerosol production, which leads to cross contamination