From the article, it doesn't look like they've implanted it yet.
You are right about the possible problems with immune reaction though. Macrophages like to eat things that are below the 40-micron range, but once you get really really small, like around the size of a single cell membrane receptor, the macrophages don't seem to react to things that size. So, in actuality, some of these nano-materials have been ok as far as immune reactions, but again, that's not to say that this one will. In fact, with any collagen biomaterial, you get antibody formation in about 39% of humans.
I'll just point out that people have been fooling around with this stuff for years. Second, just because you mimic the structure of bone doesn't mean that the bone in your body gives a damn. Bone will grow over any "osteoconductive" material depending on the architecture of the scaffold that you make out of it. Surface nanostructures have been shown to effect bone cells in petri dishes but in terms of a full-on in vivo test, they are difficult to work with because they are so delicate, as I imagine this would be.
Also, though I didn't look up the article itself, there didn't seem to be any in vivo testing. It just looked like a plain old characterization of a (not-so-)new material.
Examples of things like it on the market: MasterGraft by Medtronic, ViTOSS by Orthovita, and others
Man, wake me up when something interesting comes along. Having a degree in this subject, I'll just point out that people have been fooling around with this stuff for years, and this article doesn't even represent a small advancement.
Second, just because you mimic the structure of bone doesn't mean that the bone in your body gives a damn. Bone will grow over any "osteoconductive" material depending on the architecture of the scaffold that you make out of it. Surface nanostructures have been shown to effect bone cells in petri dishes but in terms of a full-on in vivo test, they are difficult to work with because they are so delicate, as I imagine this would be.
Also, though I didn't look up the article itself, there didn't seem to be any in vivo testing. It just looked like a plain old characterization of a (not-so-)new material, which means it's pretty much worthless for any human use at least for the next two years.
Don't hold your breath for this technology in your case, but there are a LOT of things you can do to tweak your odds.
Don't smoke.
Don't drink.
Don't take any kind of corticosteroids.
Don't take Vioxx or Celebrex for the pain because they inhibit bone healing.
If you are overweight, lose weight so when you can weight-bare again you'll have less of a chance of refracturing.
Get a Pulsed electromagnetic field (PEMF) unit, otherwise known as the EBI Bone Healing System.
http://www.youtube.com/watch?v=U1KuC3sJ6uU
Instead of making a surface where people depress some kind of dynamo, why not just capture vibrations generated from walking on the floor?
That way, you're only using *wasted* energy which is normally dissipated in the form of sound, vibrations, and heat, rather than make people work to walk on a squishy floor.
Wow, do you go to Rutgers, by chance? That sounds exactly like the kind of thing they would do just to screw someone over.... sorta like the time they took away my financial aide AFTER the semester was over.
Sure, Your Honor, please accept my RAM neatly packed in a box full of fluffy software to cushion any impact from shipping. Shall I compile a cover letter with that?
Does this crap actually happen in real companies like Marriott?? I thought that only my fellow marketing and IT people in the biomedical industry were that stupid.
Don't worry. They're fixing the whole foam issue in the next space craft by simply redoing the whole design to go back to the Saturn V rocket of the late 60's/early 70's.
I think the plans for the rocket coming after the new crew exploration vehicle involve some fireworks strapped to a chair.
I couldn't agree more. Look at the moderates of the world to understand the general sense of personal freedom AND responsibility that should be the norm. Conservatives don't understand that having strict views is ok so long as you don't force them on others. "Do what you want, so long as it doesn't scare (or hurt) the neighbors' dog."
Don't even get me started on what the liberals do wrong.
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You are right about the possible problems with immune reaction though. Macrophages like to eat things that are below the 40-micron range, but once you get really really small, like around the size of a single cell membrane receptor, the macrophages don't seem to react to things that size. So, in actuality, some of these nano-materials have been ok as far as immune reactions, but again, that's not to say that this one will. In fact, with any collagen biomaterial, you get antibody formation in about 39% of humans.
I'll just point out that people have been fooling around with this stuff for years. Second, just because you mimic the structure of bone doesn't mean that the bone in your body gives a damn. Bone will grow over any "osteoconductive" material depending on the architecture of the scaffold that you make out of it. Surface nanostructures have been shown to effect bone cells in petri dishes but in terms of a full-on in vivo test, they are difficult to work with because they are so delicate, as I imagine this would be.
Also, though I didn't look up the article itself, there didn't seem to be any in vivo testing. It just looked like a plain old characterization of a (not-so-)new material.
Examples of things like it on the market: MasterGraft by Medtronic, ViTOSS by Orthovita, and others
Man, wake me up when something interesting comes along. Having a degree in this subject, I'll just point out that people have been fooling around with this stuff for years, and this article doesn't even represent a small advancement. Second, just because you mimic the structure of bone doesn't mean that the bone in your body gives a damn. Bone will grow over any "osteoconductive" material depending on the architecture of the scaffold that you make out of it. Surface nanostructures have been shown to effect bone cells in petri dishes but in terms of a full-on in vivo test, they are difficult to work with because they are so delicate, as I imagine this would be. Also, though I didn't look up the article itself, there didn't seem to be any in vivo testing. It just looked like a plain old characterization of a (not-so-)new material, which means it's pretty much worthless for any human use at least for the next two years.
Don't hold your breath for this technology in your case, but there are a LOT of things you can do to tweak your odds. Don't smoke. Don't drink. Don't take any kind of corticosteroids. Don't take Vioxx or Celebrex for the pain because they inhibit bone healing. If you are overweight, lose weight so when you can weight-bare again you'll have less of a chance of refracturing. Get a Pulsed electromagnetic field (PEMF) unit, otherwise known as the EBI Bone Healing System. http://www.youtube.com/watch?v=U1KuC3sJ6uU
Instead of making a surface where people depress some kind of dynamo, why not just capture vibrations generated from walking on the floor? That way, you're only using *wasted* energy which is normally dissipated in the form of sound, vibrations, and heat, rather than make people work to walk on a squishy floor.
All I can think about is how much that 50 quid bounty would be after 1000 years of compounded interest.
Wow, do you go to Rutgers, by chance? That sounds exactly like the kind of thing they would do just to screw someone over.... sorta like the time they took away my financial aide AFTER the semester was over.
Sure, Your Honor, please accept my RAM neatly packed in a box full of fluffy software to cushion any impact from shipping. Shall I compile a cover letter with that?
I've got a bad feeling about this.
...the slutty drunken sorority moon of Jupiter.
You know... a micro-environment. A place with a very small amount of water where you can float very small rocks.
Does this crap actually happen in real companies like Marriott?? I thought that only my fellow marketing and IT people in the biomedical industry were that stupid.
Don't worry. They're fixing the whole foam issue in the next space craft by simply redoing the whole design to go back to the Saturn V rocket of the late 60's/early 70's. I think the plans for the rocket coming after the new crew exploration vehicle involve some fireworks strapped to a chair.
I couldn't agree more. Look at the moderates of the world to understand the general sense of personal freedom AND responsibility that should be the norm. Conservatives don't understand that having strict views is ok so long as you don't force them on others. "Do what you want, so long as it doesn't scare (or hurt) the neighbors' dog." Don't even get me started on what the liberals do wrong.
"Sheister"
Here's a solution: http://www.avlis.org/ Not *massive* multiplayer, but has all the other qualities you talk about.