Seven years of college down the DRAIN! -John Belushi
Not really. He would have been recorded as having 16 years of education (12 for high school, 4 for college four-year degree), not 19 years (12 for high school, 7 for actual physical years).
I should point out that most people developing Alzheimers today did, in fact, go to school a long time ago.
Many develop the disease between 55 and 95, so let's take the median, which is 75 (actually, more like 72, since fewer people are 95 than 55), so they went to school from ages 6 to 18 or 6 to 24, which means they went to college in the 1940s or thereabouts.
1. People with more education develop Alzheimers later; and 2. People with more education take longer to deteriorate due to Alzheimer's but progress thru the symptoms faster.
Based on the data (and there is no truth to me having a stack of Alzheimer's patient data and control data on my desk... ok, maybe there is, but I'm NOT a PhD in the field, nor am I an M.D.), we could correctly visualize it this way:
A. If you are highly educated, you may (or may not) have a long way to fall before your symptoms become obvious to others - the tests we have measure your abilities to do various tests, remember things, all kinds of stuff that you may develop strategies to compensate for given higher education (or don't develop strategies).
B. If you start with a high level of ability, you have a longer way to fall before unable to complete tasks, but if the disease affects your neural pathways (and it does, and we do need more brains, so we can study that, got one to spare?) then going from 200 to 150 to 100 to 50 to dead is similar to going from 100 to 75 to 50 to 25 to dead. Same time, sharper fall. However, you may be more capable for a longer time. Note, I did not say IQ, but ability - not the same thing at all.
Again, to get the real answers, you should read the original paper as published in the original scientific journal.
But, in the end, seems the best thing you can do is: a. get some exercise, even if just gardening or walking to the grocery store to buy milk; b. increase your mental abilities, because then if you do start failing, you'll be capable much longer, which is better; c. realize that you have less than a 5 percent risk around 60-70 and a 20 percent risk around 90+ d. you'll probably die from the massive storm caused from Global Warming kicking up the power on your Sunset cruise in the Caribbean when you retire anyway, so this is all moot.
Don't get me wrong; I'm sure it is above board, and from all I see it's good people running the place.
But this is rather like the issue of software licensing. You can have a great group of people doing wonderful work, and you know they will share the work right back with the community.
True, but in the end we come back to the scientific dilemma of sharing code (open source) and information (public research science).
Anyone can file a patent, but it's a lot harder to do so if there's prior art - and when you help an open project like what the Baker Lab does, there's a much greater chance that that will create prior art, and hence not lead to restrictive patents.
David's a nice guy. He runs a good lab, and they do good work that a lot of other good scientists use, but I can't guarantee anything since he's not me.
But, on the other hand, you could just send him an email or phone him, he's in the online directory of staff, students, and faculty. Just look up David Baker and send him an email or click on the entry and get his full mailing address, UW mail stop, and phone/fax - I'm sure he'd be glad to answer questions directly (naturally, since he's the PI of the Lab, and has a teaching load of a Professor as well,...).
Maybe he can clarify it further.
Better stories, conflicting motivations, yes
on
What is Next-Gen?
·
· Score: 1
Bigger worlds, better artificial intelligence, more expansive storylines, more things to do, and better ways to play - these are aspects that will expand the scope of games and bring them into this "next-generation."
I'd agree with the article that better multi-character story plots and reaction gradients from alterable characteristics/reactions would help. Characters being both good-natured and helpful, but willing to sell you out to save their little sister from the gallows or for a lot of the local currency, that would make it more next-gen. Having characters react based on your personal history - and sometimes forget or ignore things - yup.
Not sure about bigger worlds though. Richer, more complex, deeper worlds - sure.
I'd agree. at this point, it's not the graphics, the droplets of water spattering on the ground. instead, it's the feel, the sound, the realistic physics of stubbed toes when my troll kicks the castle wall and his right foot moves a little bit less and jerks from pain.
Or the slower reaction as my character gets tired or wounded. the involuntary camera pitch from the head nod when my sleep meter is almost empty and I haven't moved while I wait in ambush.
The involuntary jerk when the cannonball hits next to me, or the tree almost hits me. The shudder of the ground on my camera view, and the slight tilt from the impact wave.
I can, however, as someone who worked on the same floor as the Baker Labs - they're in J wing, I was in K-wing, and David Baker's been at many Biochem seminars that I've been to, attest that the vast and overwhelming (something like 90+ percent) of Protein Structures developed by Folding Predictions are for other open research, usually funded by NIH, NIAID, and various equivalent groups in places like the UK, where the research is published in Science or Nature or Cell and they're not used for restrictive patents.
Is that helpful?
I'm now over by Lake Union, but my girlfriend works one floor down from the Baker Labs at the UW, so I can attest it's pretty above-board.
Will, formerly of Biochemistry, now of Medical Genetics (Dept of Medicine)
or at least, with Nintendo's Satoru Iwata, we should expect to here about something other than Nintendogs: Roaming Wild and Animal Crossing: The Path To World Domination.
Personally, I always enjoy Will Wright. Something about the name just inspires confidence and trust. Yeah, Will, that's a good name...
Plus, I've always wanted to get an Office Foamy the Squirrel edition - that's the one that comes with Java, lots of Java, and instead of Clippy annoying you there's this squirrel who obviously has a caffeine addiction problem and talks a lot.
Of course, the online help is a little squirrely, with suggestions like this:
"Whatcha doin? Oh, not another one of those memo things, are you? Weren't you going to get me some coffee?"
and
"Time for another Foamy rant: What's with all these Saves you keep doing? I mean, do you really need to save the document every time you go to the bathroom? And could you flush next time, it's starting to reek in here. And don't turn off the monitor, I can't see your cat to torment it when you do that."
and, of course, the obligitory Foamy the Squirrel songs when you start typing something really really boring.
Yup, hope they give us the student/staff discount for that one.
While you have a good point, in that it might be used for restrictive medical patents, as a Bioinformatician I've actually used some of their genetic libraries for pattern matching as part of open scientific research funded by NIH, NIAID, and now NIA.
So, since the BBC is just the front for a great scientific college, I'd be ok with that.
You could always help out the Baker Labs here at the University of Washington, folding proteins with your spare CPU cycles. The protein folding is for various projects worldwide, the vast majority of which are all public research, and hence not used for restrictive patents.
You really should get your news from sources other than slashdot sometime.
The "lawyer" in question was Cheney's hunting buddy. He accidentally peppered the guy in the chest and face with bird shot from about 30 yards away. Most of the pellets did not go very deep, but one worked it's way to the heart, eventually causing a heart attack. He's recovering.
Good thing Cheney wasn't drinking again.
He might have tried to install BSD on top of OS/X.
Or were you refering to some nefarious hackers getting it to run on an Intel Mac? They're probably hours away from that already with one of the beta versions of Windows. Heck, I'll bet someone has already submitted it and it's been rejected because we're already had enough excitement for this week (what with Cheney shooting a Lawyer and such.)
Sorry, here's the Baker Lab link, for the Biochemical Structure prediction effort, folding proteins with your home computer. They also have another Beta for a different project as well.
I am concerned about sending my spare CPU time overseas, i mean, they say they are "climate modeling", but could they not just as easily be selling this "distributed" computer network to the black market, or Iran, or doing nuclear weapons simulations?
You could always donate your CPU cycles to help Fold Proteins at the Baker Lab here at the University of Washington.
Then you'd know your CPU cycles were doing good American scientific research.
How do I know that they won't take the work of my processor and only allow people in the UK to view the aggregate results? "I'm sorry, but the final assembly work was paid for by our TV tax, which you don't pay, so go away."
You can always sign up and pretend you're from Leeds - they don't actually check where the account is actually located, provided you use a.uk or.eu or.com site that has service in the UK.
Slashdot Mirror
And I for one will find it hard to keep my hand-cranked game console running without Arabian crude!
Actually, Reagan was useful in that so much of his life - and the progression of the disease - was both publicly documented and observed.
So how exactly is this being measured? From what I can find, all the story mentions is:
"All the patients underwent around four neurological assessments, each of which comprised a dozen separate tests of brain function."
Well, let's see, there's a Physical evaluation, Hachinski Ischemic Scale, UPDRS Motor Exam, Clinical Dementia Rating Scale (CDR), Neuropsychiatric Inventory (NPI), Behavioral Assesment - Geriatric Depression Scale (GDS), Functional Assessment (FAQ), Clinicial Judgement of Symptoms Onset, Neuropsychological Battery ( Digit Span Forward/Backward, Category Fluency, Trail Making Tests, WAIS-R Digit Symbol, Logical Memory IIA, Boston Naming Test), Lawton-Brody PSMS, Mini Mental State Exam. Plus others done by different research centers for their particular study.
Is that useful? If not, check out www.nacc.org for more info.
In the uneducated, you just can't tell the difference.
Then how do you explain George?
Seven years of college down the DRAIN! -John Belushi
Not really. He would have been recorded as having 16 years of education (12 for high school, 4 for college four-year degree), not 19 years (12 for high school, 7 for actual physical years).
At least for US data measurement standards.
I should point out that most people developing Alzheimers today did, in fact, go to school a long time ago.
Many develop the disease between 55 and 95, so let's take the median, which is 75 (actually, more like 72, since fewer people are 95 than 55), so they went to school from ages 6 to 18 or 6 to 24, which means they went to college in the 1940s or thereabouts.
They said:
... ok, maybe there is, but I'm NOT a PhD in the field, nor am I an M.D.), we could correctly visualize it this way:
1. People with more education develop Alzheimers later; and
2. People with more education take longer to deteriorate due to Alzheimer's but progress thru the symptoms faster.
Based on the data (and there is no truth to me having a stack of Alzheimer's patient data and control data on my desk
A. If you are highly educated, you may (or may not) have a long way to fall before your symptoms become obvious to others - the tests we have measure your abilities to do various tests, remember things, all kinds of stuff that you may develop strategies to compensate for given higher education (or don't develop strategies).
B. If you start with a high level of ability, you have a longer way to fall before unable to complete tasks, but if the disease affects your neural pathways (and it does, and we do need more brains, so we can study that, got one to spare?) then going from 200 to 150 to 100 to 50 to dead is similar to going from 100 to 75 to 50 to 25 to dead. Same time, sharper fall. However, you may be more capable for a longer time. Note, I did not say IQ, but ability - not the same thing at all.
Again, to get the real answers, you should read the original paper as published in the original scientific journal.
But, in the end, seems the best thing you can do is:
a. get some exercise, even if just gardening or walking to the grocery store to buy milk;
b. increase your mental abilities, because then if you do start failing, you'll be capable much longer, which is better;
c. realize that you have less than a 5 percent risk around 60-70 and a 20 percent risk around 90+
d. you'll probably die from the massive storm caused from Global Warming kicking up the power on your Sunset cruise in the Caribbean when you retire anyway, so this is all moot.
your conscious and subconscious mind will merge and integrate.
It's actually quite nice, really, but it also means you don't really remember a lot of your dreams.
And then, you start into Tao, cause Zen is really lacking in a sense of humor, which is the only way to Truly See The World.
Me, I prefer the Tao of Piglet
Don't get me wrong; I'm sure it is above board, and from all I see it's good people running the place.
...).
But this is rather like the issue of software licensing. You can have a great group of people doing wonderful work, and you know they will share the work right back with the community.
True, but in the end we come back to the scientific dilemma of sharing code (open source) and information (public research science).
Anyone can file a patent, but it's a lot harder to do so if there's prior art - and when you help an open project like what the Baker Lab does, there's a much greater chance that that will create prior art, and hence not lead to restrictive patents.
David's a nice guy. He runs a good lab, and they do good work that a lot of other good scientists use, but I can't guarantee anything since he's not me.
But, on the other hand, you could just send him an email or phone him, he's in the online directory of staff, students, and faculty. Just look up David Baker and send him an email or click on the entry and get his full mailing address, UW mail stop, and phone/fax - I'm sure he'd be glad to answer questions directly (naturally, since he's the PI of the Lab, and has a teaching load of a Professor as well,
Maybe he can clarify it further.
Bigger worlds, better artificial intelligence, more expansive storylines, more things to do, and better ways to play - these are aspects that will expand the scope of games and bring them into this "next-generation."
I'd agree with the article that better multi-character story plots and reaction gradients from alterable characteristics/reactions would help. Characters being both good-natured and helpful, but willing to sell you out to save their little sister from the gallows or for a lot of the local currency, that would make it more next-gen. Having characters react based on your personal history - and sometimes forget or ignore things - yup.
Not sure about bigger worlds though. Richer, more complex, deeper worlds - sure.
I'd agree. at this point, it's not the graphics, the droplets of water spattering on the ground. instead, it's the feel, the sound, the realistic physics of stubbed toes when my troll kicks the castle wall and his right foot moves a little bit less and jerks from pain.
Or the slower reaction as my character gets tired or wounded. the involuntary camera pitch from the head nod when my sleep meter is almost empty and I haven't moved while I wait in ambush.
The involuntary jerk when the cannonball hits next to me, or the tree almost hits me. The shudder of the ground on my camera view, and the slight tilt from the impact wave.
now, that's next gen.
I agree, there is no guarantee.
I can, however, as someone who worked on the same floor as the Baker Labs - they're in J wing, I was in K-wing, and David Baker's been at many Biochem seminars that I've been to, attest that the vast and overwhelming (something like 90+ percent) of Protein Structures developed by Folding Predictions are for other open research, usually funded by NIH, NIAID, and various equivalent groups in places like the UK, where the research is published in Science or Nature or Cell and they're not used for restrictive patents.
Is that helpful?
I'm now over by Lake Union, but my girlfriend works one floor down from the Baker Labs at the UW, so I can attest it's pretty above-board.
Will, formerly of Biochemistry, now of Medical Genetics (Dept of Medicine)
nah, Will has Free Will turned off when he's at work.
He only turns on Free Will when he's not working.
or at least, with Nintendo's Satoru Iwata, we should expect to here about something other than Nintendogs: Roaming Wild and Animal Crossing: The Path To World Domination.
...
Personally, I always enjoy Will Wright. Something about the name just inspires confidence and trust. Yeah, Will, that's a good name
We need a new biotech wing here at the UW.
Plus, I've always wanted to get an Office Foamy the Squirrel edition - that's the one that comes with Java, lots of Java, and instead of Clippy annoying you there's this squirrel who obviously has a caffeine addiction problem and talks a lot.
Of course, the online help is a little squirrely, with suggestions like this:
"Whatcha doin? Oh, not another one of those memo things, are you? Weren't you going to get me some coffee?"
and
"Time for another Foamy rant: What's with all these Saves you keep doing? I mean, do you really need to save the document every time you go to the bathroom? And could you flush next time, it's starting to reek in here. And don't turn off the monitor, I can't see your cat to torment it when you do that."
and, of course, the obligitory Foamy the Squirrel songs when you start typing something really really boring.
Yup, hope they give us the student/staff discount for that one.
all of the new formats?
Or do we have to download it from a European site to get around the software "patents" they probably "included"?
That's all I want to know about Office 12 um 2007 um 2008 um 2009 um bugfix coming real soon now please don't replace us.
but $2,276 seems like a lot for a computer these days.
Yes, it is. My current laptop cost me $500, for a much more powerful CPU (also an AMD), with more RAM, and better wireless.
While you have a good point, in that it might be used for restrictive medical patents, as a Bioinformatician I've actually used some of their genetic libraries for pattern matching as part of open scientific research funded by NIH, NIAID, and now NIA.
So, since the BBC is just the front for a great scientific college, I'd be ok with that.
You could always help out the Baker Labs here at the University of Washington, folding proteins with your spare CPU cycles. The protein folding is for various projects worldwide, the vast majority of which are all public research, and hence not used for restrictive patents.
You really should get your news from sources other than slashdot sometime.
The "lawyer" in question was Cheney's hunting buddy. He accidentally peppered the guy in the chest and face with bird shot from about 30 yards away. Most of the pellets did not go very deep, but one worked it's way to the heart, eventually causing a heart attack. He's recovering.
Good thing Cheney wasn't drinking again.
He might have tried to install BSD on top of OS/X.
Or were you refering to some nefarious hackers getting it to run on an Intel Mac? They're probably hours away from that already with one of the beta versions of Windows. Heck, I'll bet someone has already submitted it and it's been rejected because we're already had enough excitement for this week (what with Cheney shooting a Lawyer and such.)
Cheney shot a lawyer?
My, I need to keep on current events more.
So, when's the trial?
Sorry, here's the Baker Lab link, for the Biochemical Structure prediction effort, folding proteins with your home computer. They also have another Beta for a different project as well.
I am concerned about sending my spare CPU time overseas, i mean, they say they are "climate modeling", but could they not just as easily be selling this "distributed" computer network to the black market, or Iran, or doing nuclear weapons simulations?
You could always donate your CPU cycles to help Fold Proteins at the Baker Lab here at the University of Washington.
Then you'd know your CPU cycles were doing good American scientific research.
And Prof. Baker is a neat guy, very slashdot.
thanks for the link!
expect to see it in, oh, maybe five years.
How do I know that they won't take the work of my processor and only allow people in the UK to view the aggregate results? "I'm sorry, but the final assembly work was paid for by our TV tax, which you don't pay, so go away."
.uk or .eu or .com site that has service in the UK.
You can always sign up and pretend you're from Leeds - they don't actually check where the account is actually located, provided you use a