Wouldn't say commonly, there are many other options for most common infections besides streptomycin, like cephalosporins, aztreonam, or a number of non-beta lactam antibiotics. Streptomycin is used (in the US) for rare stuff like tularemia and plague (Y. pestis).
Source: I am a physician
Let me preface by saying I am a Gastroenterologist; you obviously have discussed the options here, and it sounds like you've developed a fibrostenotic stricture. While retrieving the capsule may give you some peace of mind for a while, it will not address the underlying issue, namely the fibrosis that has developed in this segment of bowel.
First, you need to be on biologic therapy, either an anti-TNF like remicade, humira or cimzia, or one of the newer drugs such as entyvio, or things will, eventually get worse.
Assuming this is already the case, I would proceed with a small bowel resection, performed by an experienced colo-rectal surgeon, preferably one with extensive experience inflammatory bowel disease. If you have not had a recent MR enterography, they can run the small bowel during surgery to evaluate for any other likely strictured or heavily diseased areas. I would not be in favor of stricturoplasty as recommended above, as recurrence rate is higher with stricturoplasty.
I just used the firmware that came on it, which is...fine. More impressed with the hardware than many more expensive pieces I've owned. I think I have had to hard reboot it 3 times in the time I've owned it. Not sure why they're not more popular.
I've sworn off buying their crap after going 3/3 on their routers developing hardware failures. Bought a ubiquity wireless access point 3 years ago and haven't looked back
These people have generally made up their minds despite all the evidence to the contrary, often down the "I don't trust this vaccine" or the "the vaccine will be worse than the disease" or even the whole disproven autism connection. Despite my attempting to explain the benefits and science behind it, these patients rarely change their minds - and I treat adults. The most commonly given vaccines we give to adults are all either protein, polysaccharide or heat killed and have near zero ability to infect or cause anything beyond local irritation or at worst an allergic reaction in egg- allergic patients for the flu shot. I can explain all that and the immunology and science behind it (if I care to run way over the 20 minutes allotted for a patient visit) and hardly anyone changes their minds. (Clearly, I am a physician)
I just doubt much in the way of the content is going to change significantly - the slashvertisements, the bitching and moaning about the relevance of the posts. It'll probably just be business as usual.
That's actually entirely wrong. I am a physician who gives gardasil to young adults routinely - it is approved through age 26 in men and women. The vaccine is a combination of 4 recombinant capsid proteins, one from each of 4 strains of hpv. The only genetic manipulation was inserting the genes for these proteins into yeast for mass production. Injected into the body it works like any other vaccine that doesn't consist of live virus. And finally, the reason it is indicated for young people is to give them protection before encountering the virus. You could give it to a 40 year old virgin with the same effect. The problem is it is so prevalent that most people are exposed by the time they are 30. Let's not forget that hpv is the cause of most anal cancers in men, including straight men, as the virus has been shown to migrate from the scrotal skin up the perineum to the anus where it basically replicates in much the same way as the cervix.
Surprise! Healthcare professionals have ALWAYS been able to (and in fact, are required) to report mentally ill people who express a plan to hurt themselves or others, even if they are not known to have access to firearms. Source: I am a physician, and have taken multiple, mandatory, work related "mandatory reporter" courses
I jerry rigged an intrabdominal pressure sensor by clamping a foley catheter and connecting the sample port to an arterial line transducer, then used it to diagnose abdominal compartment syndrome in a cirrhotic patient.
And helps make sense of the situation is that when a galaxy becomes causally disconnected from us, it's not that the distance between us has expanded so far that light no longer has "time" to reach us, it's that the photons carrying that information have become so redshifted that they have a wavelength equal to or larger than the observable universe and are thus undetectable, although in practice this happens well before reaching a wavelength that large
Actually, given that there's 100-400 billion stars in the galaxy, and 0.001^4 works out to one in a trillion, that gives you about a 10 to 40% chance of there being one intelligent species in the milky way./semantic
But I agree, in general. The odds of earth being the only planet with life at all in the whole galaxy...are pretty astronomical, in my opinion.
C. diff infections are NOT always caused by antibiotic "overdose," which isn't really a thing - there's dose related toxicity for some classes of antibiotics, but not overdose. In the healthcare setting, infections are usually caused by overgrowth in the setting of depleted colonic flora, but symptomatic infections can also happen with contact with a patient already experiencing a C. diff infection - two years ago, a resident at my hospital ended up with such a severe infection she picked up from a patient that she nearly ended up with a total colectomy. In the community setting, about 50% of cases occurred without any prior antibiotic exposure in the past 30-90 days, at least according to a recent meta-analysis [http://www.ncbi.nlm.nih.gov/pubmed/25058469].
These are for patients who have recurrent C. diff, who have already failed PO vancomycin or fidaxomycin (difficid). Those are the only two antibiotics we really have after you fail metronidazole therapy. It's not an issue of strongness; it's penetrating into encysted bacteria which vancomycin does fairly poorly, and fidaxomycin does only moderately better. At that point, options are fecal therapy, another round of vanc or difficid with increasingly diminishing returns, or in severe cases, colectomy.
I own stock in the company conducting the trial (AMEX: CUR), and this phase I study is really more of a formality, as they have finished injections in the cervical and lumbar spine for a phase IIB study using the same stem cells in ALS patients; thus far the safety profile has been excellent (efficacy hasn't been rigorously looked at yet, but the initial results are promising). The results in rat models for spinal cord injury were very impressive, if this stuff translates it'll be a real game changer...I've read most of their published data so far and everything looks legit.
The time period over which pair production-annhilation occurs might be a small part of the correction here, but from my quick reading of TFA, I think the key phrase is "This results in a small correction to the angular frequency of a photon and thus its velocity," where velocity is the key word. Velocity of course is a vector quantity, consisting of both a speed (c) and a direction. The key aspect here is the direction; when the pair recombines, the total energy of the system is slightly different as the positron-electron pair is affected by gravity and thus may pick up a small positive or negative acceleration from the gravitational potential they are traveling through. When they recombine this will be reflected in the new velocity (c d) of the resultant photon, which is not exactly the same as the photon prior to pair production.
At least thats what I got, but I'm the wrong kind of doctor to be an expert in this. Any PhD's wanna weigh in and correct me, please do!
in residency, and yes, from time to time I'll look up something on wikipedia on my phone for a quick overview if its a condition I'm not familiar with, or is outside my specialty, and I'm rounding or otherwise away from a computer. However, I don't use it for treatment or diagnostic purposes; there exist much better, peer reviewed sources for that, which I will happily access from a computer. That being said, I'd say a large amount of the wikipedia articles tend to be pretty decent, and at least sound as if they've been written by someone with some sort of formal medical treatment. They get the quick and dirty job done about 75% of the time for me.
Excellent idea, from my understanding of the process demonstrated above, yes, this could work, as this would be above the neurological level of the lesion in most patients suffering from locked in syndrome. - I am a physician.
I submitted the article. I called it a QC, because if you read TFS, there are a couple of papers linked indicating that there seems to be evidence that the machine is functioning as an adiabatic quantum computer. Of course, these results have been challenged. However, for the purposes of a summary, it seemed in my mind, ok to call it what the manufacturer does, which is an adiabatic quantum computer.
Slashdot Mirror
Wouldn't say commonly, there are many other options for most common infections besides streptomycin, like cephalosporins, aztreonam, or a number of non-beta lactam antibiotics. Streptomycin is used (in the US) for rare stuff like tularemia and plague (Y. pestis). Source: I am a physician
Let me preface by saying I am a Gastroenterologist; you obviously have discussed the options here, and it sounds like you've developed a fibrostenotic stricture. While retrieving the capsule may give you some peace of mind for a while, it will not address the underlying issue, namely the fibrosis that has developed in this segment of bowel. First, you need to be on biologic therapy, either an anti-TNF like remicade, humira or cimzia, or one of the newer drugs such as entyvio, or things will, eventually get worse. Assuming this is already the case, I would proceed with a small bowel resection, performed by an experienced colo-rectal surgeon, preferably one with extensive experience inflammatory bowel disease. If you have not had a recent MR enterography, they can run the small bowel during surgery to evaluate for any other likely strictured or heavily diseased areas. I would not be in favor of stricturoplasty as recommended above, as recurrence rate is higher with stricturoplasty.
I just used the firmware that came on it, which is...fine. More impressed with the hardware than many more expensive pieces I've owned. I think I have had to hard reboot it 3 times in the time I've owned it. Not sure why they're not more popular.
I've sworn off buying their crap after going 3/3 on their routers developing hardware failures. Bought a ubiquity wireless access point 3 years ago and haven't looked back
These people have generally made up their minds despite all the evidence to the contrary, often down the "I don't trust this vaccine" or the "the vaccine will be worse than the disease" or even the whole disproven autism connection. Despite my attempting to explain the benefits and science behind it, these patients rarely change their minds - and I treat adults. The most commonly given vaccines we give to adults are all either protein, polysaccharide or heat killed and have near zero ability to infect or cause anything beyond local irritation or at worst an allergic reaction in egg- allergic patients for the flu shot. I can explain all that and the immunology and science behind it (if I care to run way over the 20 minutes allotted for a patient visit) and hardly anyone changes their minds. (Clearly, I am a physician)
Maybe. That's assuming they don't scale up their operations accordingly
I just doubt much in the way of the content is going to change significantly - the slashvertisements, the bitching and moaning about the relevance of the posts. It'll probably just be business as usual.
same as the old boss
That's actually entirely wrong. I am a physician who gives gardasil to young adults routinely - it is approved through age 26 in men and women. The vaccine is a combination of 4 recombinant capsid proteins, one from each of 4 strains of hpv. The only genetic manipulation was inserting the genes for these proteins into yeast for mass production. Injected into the body it works like any other vaccine that doesn't consist of live virus. And finally, the reason it is indicated for young people is to give them protection before encountering the virus. You could give it to a 40 year old virgin with the same effect. The problem is it is so prevalent that most people are exposed by the time they are 30. Let's not forget that hpv is the cause of most anal cancers in men, including straight men, as the virus has been shown to migrate from the scrotal skin up the perineum to the anus where it basically replicates in much the same way as the cervix.
Care to show any shred of evidence about that?
Surprise! Healthcare professionals have ALWAYS been able to (and in fact, are required) to report mentally ill people who express a plan to hurt themselves or others, even if they are not known to have access to firearms. Source: I am a physician, and have taken multiple, mandatory, work related "mandatory reporter" courses
I jerry rigged an intrabdominal pressure sensor by clamping a foley catheter and connecting the sample port to an arterial line transducer, then used it to diagnose abdominal compartment syndrome in a cirrhotic patient.
People conflate "side effect" with allergy. Urticaria (hives) is an allergy to penicillin. Nausea, diarrhea, and vomiting is a side effect
And helps make sense of the situation is that when a galaxy becomes causally disconnected from us, it's not that the distance between us has expanded so far that light no longer has "time" to reach us, it's that the photons carrying that information have become so redshifted that they have a wavelength equal to or larger than the observable universe and are thus undetectable, although in practice this happens well before reaching a wavelength that large
Actually, given that there's 100-400 billion stars in the galaxy, and 0.001^4 works out to one in a trillion, that gives you about a 10 to 40% chance of there being one intelligent species in the milky way. /semantic
But I agree, in general. The odds of earth being the only planet with life at all in the whole galaxy...are pretty astronomical, in my opinion.
C. diff infections are NOT always caused by antibiotic "overdose," which isn't really a thing - there's dose related toxicity for some classes of antibiotics, but not overdose. In the healthcare setting, infections are usually caused by overgrowth in the setting of depleted colonic flora, but symptomatic infections can also happen with contact with a patient already experiencing a C. diff infection - two years ago, a resident at my hospital ended up with such a severe infection she picked up from a patient that she nearly ended up with a total colectomy. In the community setting, about 50% of cases occurred without any prior antibiotic exposure in the past 30-90 days, at least according to a recent meta-analysis [http://www.ncbi.nlm.nih.gov/pubmed/25058469].
These are for patients who have recurrent C. diff, who have already failed PO vancomycin or fidaxomycin (difficid). Those are the only two antibiotics we really have after you fail metronidazole therapy. It's not an issue of strongness; it's penetrating into encysted bacteria which vancomycin does fairly poorly, and fidaxomycin does only moderately better. At that point, options are fecal therapy, another round of vanc or difficid with increasingly diminishing returns, or in severe cases, colectomy.
I own stock in the company conducting the trial (AMEX: CUR), and this phase I study is really more of a formality, as they have finished injections in the cervical and lumbar spine for a phase IIB study using the same stem cells in ALS patients; thus far the safety profile has been excellent (efficacy hasn't been rigorously looked at yet, but the initial results are promising). The results in rat models for spinal cord injury were very impressive, if this stuff translates it'll be a real game changer...I've read most of their published data so far and everything looks legit.
The time period over which pair production-annhilation occurs might be a small part of the correction here, but from my quick reading of TFA, I think the key phrase is "This results in a small correction to the angular frequency of a photon and thus its velocity," where velocity is the key word. Velocity of course is a vector quantity, consisting of both a speed (c) and a direction. The key aspect here is the direction; when the pair recombines, the total energy of the system is slightly different as the positron-electron pair is affected by gravity and thus may pick up a small positive or negative acceleration from the gravitational potential they are traveling through. When they recombine this will be reflected in the new velocity (c d) of the resultant photon, which is not exactly the same as the photon prior to pair production. At least thats what I got, but I'm the wrong kind of doctor to be an expert in this. Any PhD's wanna weigh in and correct me, please do!
oof. Clearly, I meant training...which totally didn't happen because of any sleep-deprivation, honestly...
in residency, and yes, from time to time I'll look up something on wikipedia on my phone for a quick overview if its a condition I'm not familiar with, or is outside my specialty, and I'm rounding or otherwise away from a computer. However, I don't use it for treatment or diagnostic purposes; there exist much better, peer reviewed sources for that, which I will happily access from a computer. That being said, I'd say a large amount of the wikipedia articles tend to be pretty decent, and at least sound as if they've been written by someone with some sort of formal medical treatment. They get the quick and dirty job done about 75% of the time for me.
Chad Orzel was my college physics professor. Cool dude.
Excellent idea, from my understanding of the process demonstrated above, yes, this could work, as this would be above the neurological level of the lesion in most patients suffering from locked in syndrome. - I am a physician.
I wish. I'm a broke medical intern. But hey, whatever you want to tell yourself.
I submitted the article. I called it a QC, because if you read TFS, there are a couple of papers linked indicating that there seems to be evidence that the machine is functioning as an adiabatic quantum computer. Of course, these results have been challenged. However, for the purposes of a summary, it seemed in my mind, ok to call it what the manufacturer does, which is an adiabatic quantum computer.