Forgive my naivete but when I was a little boy I thought the sun was hotter due to convection.
Hot things rise and are less dense. Cold things go down.
Except this occurs with steroids on the sun.
I'm wondering how many times the death knell for one or the other sounds.
First it's no-boobs Betamax BluRay (revised I know but yea)
Then it's Warner and the warning to HD-DVD
What next?
Is it just me or did Baylor Medical College just give every coke cartel around a massive simultaneous boner?
Cocaine acts exceedingly fast if I'm not mistaken. I can understand how a "vaccine" may induce immunological opposition to cocaine, but why on Earth bother?
1) Antibody reactions take the course of days. IgM takes days to multiply to any reasonable effect. IgG takes hours. Cocaine acts in milliseconds. It will not stop someone from guy high for a short time
2) A junkie who just took a snort and found that his high doesn't last as long may put it down to increased tolerance, and remembering that the craving persists, they'll just take more
3) Dealers end up selling more cocaine. Suddenly, for the same price, the volume of cocaine they sell may quadruple
4) More crime occurs as more low socioeconomic-status junkies resort to crime just to get more cocaine, to get the same high as before. Some may die, some may rot in jail, very few may actually give up.
This drug is the ???? in the following sequence of events:
1. Deal a drug and hope for society to miraculously increase demand
2. ????
3. Profit!
Sorry to burst your bubble but you're 90% inaccurate.
Cardiac adult stem cells have never been found to divide or do anything significant except in a petri dish. Cardiac tissue does not "regenerate" in the sense of growing new cells (a process called hyperplasia), individual cells of the heart merely expand in size themselves to make up for the deficiency in cells to take up the slack (a process called hypertrophy).
However, the process of cardiac hypertrophy also predisposes a person to heart problems, because the heart can't be supplied with enough nutrients themselves.
Whatever "regeneration" occured in this girl's case is thanks to reduced afterload upon her own heart, resulting in a possible reversal of cardiac remodelling triggered by the requirements of blood pressure. Her enlarged heart, the result of hypertrophy that TFA suggests may have been virally-triggered, would have been relieved of those pressures by the Berlin Heart.
The protein in question here is PKMzeta, which from the name I'd think is a protein kinase. Apparently it's a fragment of the enzyme Protein Kinase C-zeta, and it is crucial for its constituvely active functioning, which means that it will continuously function.
As far as I recall, there's heaps of drugs that are capable of interfering with constitutively active phosphorylation so as to inhibit or enhance function. In the case of cancer, drugs that inhibit constitutive phosphorylation ie. the use of imitanib in chronic myeloid leukaemia, have enormous utility. But what about one that enhances such functions? What about having a drug that is capable of engaging with the active site of the enzyme as a means of enhancing its function and form new memories? It'll be decades before such drugs can have clinical use, but their function as academic drugs is huge. From their use, we can learn about:
1) How long-term memories are formed and destroyed 2) How physiological and pathological processes influence these 3) The neurochemical and neuroanatomical basis of memory formation
And even then, if we wanted to make a useful drug out of this, a drug to remember as opposed to forgetting, it is a matter of molecular pharmacology, which is more up to science than serendipity. Engineering a drug to be an agonist, or antagonist thereof, has some curious applications. I may not be a pharmacologist, but from studying I've found that having a drug that agonizes or antagonizes the enzymatic or receptor machinery is contingent upon having a drug that:
1) Can fit into the active site(s) of the protein 2) Stimulate it or inhibit it thereof by altering the chemistry of the enzyme, hence enhancing function
We have here, a drug that can fit into the active site of this protein. We could quite well re-engineer it to have enhanced activity, or a longer half-life. Heck, if we wanted to, we could synthesize it and inject bucketloads into mice and see if they develop superb long-term memories. Think of the applications as an adjunct therapy for dementia...think about how mutations in this protein could be responsible for the memory savants we see today.
Of course, we're going out of our depth here. PKM-zeta seems to be well studied in mouse models, I haven't found much info on this in humans.
TFA says that the price of the imaging modality will drop in the next few years with economies of scale and so forth. This is good, very good. It means that it'll make its way into the GP's practice soon and not just be in the hands of respiratory physicians and hospitals.
But, honestly, look at things like this: TFA mentions that as far as replacing the stethoscope goes, it removes any sort of interpersonal bias between doctors in diagnosis. While this is just wonderful in respect to some esoteric diagnoses ie. whether you can *hear* a tiny small-cell carcinoma, but for the rest of us, I feel that a stethoscope, a quiet room and a competent doctor will suffice. The sounds of pneumonia, emphysema, pulmonary oedema, tuberculosis, bronchiole asthma etc. are all quite distinctive and as a medical student, I find it somewhat surprising that there can be any significant argument or doubt regarding the diagnosis of such patients. Heck, even if there was doubt, there are other elements of the presenting complaint (risk factors, family history, blood tests and plain old signs & symptoms) that can help doctors reach a definitive diagnosis.
What I'm trying to say is, the old stuff works, its tried and true, and it's not easy to honestly miss pulmonary lesions. So, apart from being a novel visual toy (I know it's an instrument but how much fun is this?!) would it HONESTLY replace a $70 stethoscope and a head full of juicy knowledge brains? Me thinks nah:-p
"Hi, I'm an electric car. I can't go very fast...or very far...and if you drive me, people will think you're gay."
"One of us, one of us"
Don't hit me *guards face*
Also consider that AMD has a massive "enthusiast" fanbase, which like colourful things. Having a row of fans with green LEDs gives it a '1337-halo' effect
Having been a dedicated AMD fanboy for many years running, I'm finding this news exciting. Also, having been a critical character, I just don't like that AMD picked that benchmark and flogging it like a dead horse. Whoop-dee-doo, your triple-Crossfire quadcore can run Vista well.
Honestly, AMD need to buck up and demonstrate, directly or otherwise (ie. by reviews):
1) Server performance
2) Performance of Barcelona/Phenom vs. Kentsfield/Conroe
3) Some monumental overclockability.
The halcyon days of Toledo Opteron overclocking is completely shadowed by Allensdale and Conroe now. Still, Brisbane 65nm shows promise in the overclocking stakes.
And for crying out loud AMDATI, fix your drivers!
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Forgive my naivete but when I was a little boy I thought the sun was hotter due to convection. Hot things rise and are less dense. Cold things go down. Except this occurs with steroids on the sun.
What about bacteria? Oh that's right :-P
I'm wondering how many times the death knell for one or the other sounds. First it's no-boobs Betamax BluRay (revised I know but yea) Then it's Warner and the warning to HD-DVD What next?
Is it just me or did Baylor Medical College just give every coke cartel around a massive simultaneous boner?
Cocaine acts exceedingly fast if I'm not mistaken. I can understand how a "vaccine" may induce immunological opposition to cocaine, but why on Earth bother?
1) Antibody reactions take the course of days. IgM takes days to multiply to any reasonable effect. IgG takes hours. Cocaine acts in milliseconds. It will not stop someone from guy high for a short time 2) A junkie who just took a snort and found that his high doesn't last as long may put it down to increased tolerance, and remembering that the craving persists, they'll just take more 3) Dealers end up selling more cocaine. Suddenly, for the same price, the volume of cocaine they sell may quadruple 4) More crime occurs as more low socioeconomic-status junkies resort to crime just to get more cocaine, to get the same high as before. Some may die, some may rot in jail, very few may actually give up. This drug is the ???? in the following sequence of events:
1. Deal a drug and hope for society to miraculously increase demand 2. ???? 3. Profit!
Sorry to burst your bubble but you're 90% inaccurate.
:-)
Cardiac adult stem cells have never been found to divide or do anything significant except in a petri dish. Cardiac tissue does not "regenerate" in the sense of growing new cells (a process called hyperplasia), individual cells of the heart merely expand in size themselves to make up for the deficiency in cells to take up the slack (a process called hypertrophy).
However, the process of cardiac hypertrophy also predisposes a person to heart problems, because the heart can't be supplied with enough nutrients themselves.
Whatever "regeneration" occured in this girl's case is thanks to reduced afterload upon her own heart, resulting in a possible reversal of cardiac remodelling triggered by the requirements of blood pressure. Her enlarged heart, the result of hypertrophy that TFA suggests may have been virally-triggered, would have been relieved of those pressures by the Berlin Heart.
Hot
The protein in question here is PKMzeta, which from the name I'd think is a protein kinase. Apparently it's a fragment of the enzyme Protein Kinase C-zeta, and it is crucial for its constituvely active functioning, which means that it will continuously function.
As far as I recall, there's heaps of drugs that are capable of interfering with constitutively active phosphorylation so as to inhibit or enhance function. In the case of cancer, drugs that inhibit constitutive phosphorylation ie. the use of imitanib in chronic myeloid leukaemia, have enormous utility. But what about one that enhances such functions? What about having a drug that is capable of engaging with the active site of the enzyme as a means of enhancing its function and form new memories? It'll be decades before such drugs can have clinical use, but their function as academic drugs is huge. From their use, we can learn about:
1) How long-term memories are formed and destroyed
2) How physiological and pathological processes influence these
3) The neurochemical and neuroanatomical basis of memory formation
And even then, if we wanted to make a useful drug out of this, a drug to remember as opposed to forgetting, it is a matter of molecular pharmacology, which is more up to science than serendipity. Engineering a drug to be an agonist, or antagonist thereof, has some curious applications. I may not be a pharmacologist, but from studying I've found that having a drug that agonizes or antagonizes the enzymatic or receptor machinery is contingent upon having a drug that:
1) Can fit into the active site(s) of the protein
2) Stimulate it or inhibit it thereof by altering the chemistry of the enzyme, hence enhancing function
We have here, a drug that can fit into the active site of this protein. We could quite well re-engineer it to have enhanced activity, or a longer half-life. Heck, if we wanted to, we could synthesize it and inject bucketloads into mice and see if they develop superb long-term memories. Think of the applications as an adjunct therapy for dementia...think about how mutations in this protein could be responsible for the memory savants we see today.
Of course, we're going out of our depth here. PKM-zeta seems to be well studied in mouse models, I haven't found much info on this in humans.
TFA says that the price of the imaging modality will drop in the next few years with economies of scale and so forth. This is good, very good. It means that it'll make its way into the GP's practice soon and not just be in the hands of respiratory physicians and hospitals. But, honestly, look at things like this: TFA mentions that as far as replacing the stethoscope goes, it removes any sort of interpersonal bias between doctors in diagnosis. While this is just wonderful in respect to some esoteric diagnoses ie. whether you can *hear* a tiny small-cell carcinoma, but for the rest of us, I feel that a stethoscope, a quiet room and a competent doctor will suffice. The sounds of pneumonia, emphysema, pulmonary oedema, tuberculosis, bronchiole asthma etc. are all quite distinctive and as a medical student, I find it somewhat surprising that there can be any significant argument or doubt regarding the diagnosis of such patients. Heck, even if there was doubt, there are other elements of the presenting complaint (risk factors, family history, blood tests and plain old signs & symptoms) that can help doctors reach a definitive diagnosis. What I'm trying to say is, the old stuff works, its tried and true, and it's not easy to honestly miss pulmonary lesions. So, apart from being a novel visual toy (I know it's an instrument but how much fun is this?!) would it HONESTLY replace a $70 stethoscope and a head full of juicy knowledge brains? Me thinks nah :-p
"Hi, I'm an electric car. I can't go very fast...or very far...and if you drive me, people will think you're gay." "One of us, one of us" Don't hit me *guards face*
Also consider that AMD has a massive "enthusiast" fanbase, which like colourful things. Having a row of fans with green LEDs gives it a '1337-halo' effect
Having been a dedicated AMD fanboy for many years running, I'm finding this news exciting. Also, having been a critical character, I just don't like that AMD picked that benchmark and flogging it like a dead horse. Whoop-dee-doo, your triple-Crossfire quadcore can run Vista well. Honestly, AMD need to buck up and demonstrate, directly or otherwise (ie. by reviews): 1) Server performance 2) Performance of Barcelona/Phenom vs. Kentsfield/Conroe 3) Some monumental overclockability. The halcyon days of Toledo Opteron overclocking is completely shadowed by Allensdale and Conroe now. Still, Brisbane 65nm shows promise in the overclocking stakes. And for crying out loud AMDATI, fix your drivers!