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Provigil Extends Your Day?

John Mearns writes "It looks like before long all caffeine junkies will be able to ditch the bottle of Mountain Dew or cup of coffee in favor of pill. Its not a true stimulant so you don't get the "caffeine crash," just countless hours of alert attentiveness. " It's also still in testing so it'll probably make you grow horns or something, and is supposed to only be used for people who are sleepy during the day, but it raises several interesting ethical questions.

169 of 631 comments (clear)

  1. First Post. by QuodEratDemonstratum · · Score: 5, Funny


    Cool, if I take these it will increase my chances of getting a first post.

    Pop pill.
    Reload /.
    Pop pill.
    Reload /.
    Pop pill.
    Reload /.
    Rinse,
    Repeat.

  2. caffene crash is great by Lumpy · · Score: 5, Interesting

    How else do i know it's time to give up and go to bed? when you finally come crashing down in the bathroom as your body is expelling all that water...

    Boom.... now sleep for 12 hours.

    I want something that will reduce my bodies need for sleep... make me feel good and refreshed on 3 or 4 hours of sleep.

    --
    Do not look at laser with remaining good eye.
    1. Re:caffene crash is great by Wonko42 · · Score: 5, Interesting

      Try Uberman's Sleep Cycle. If your schedule allows it, and you're able to adjust to the cycle, you'll end up getting around two to three hours of sleep per day (just not consecutively) and you'll feel better than after a normal eight hours of sleep. Or so people say.

    2. Re:caffene crash is great by Quixote · · Score: 5, Informative
      I saw a news magazine program once which monitored a guy doing this for weeks. They had a camera setup in the bedroom, and this dude was supposed to perform mental tasks (puzzles, memorization, etc.) at periodic intervals.

      He seemed to be getting along just fine, until about day 62 or so, and then he crashed, and crashed hard!

    3. Re:caffene crash is great by SandSpider · · Score: 4, Funny

      Yeah, some kids in my dorm did this. They had heard that DaVinci did it or something. It went for a few days, until they overslept and nothing at all would wake them. They only missed a few classes.

      =Brian

      --
      There is nothing so good that someone, somewhere, will not hate it.
    4. Re:caffene crash is great by Guppy06 · · Score: 3, Informative

      As I've learned the hard way in recent years, you NEED several hours of REM sleep a day. It's not just a matter of feeling "refreshed" in the morning, it's a big factor in mental health.

    5. Re:caffene crash is great by dbretton · · Score: 5, Funny

      That's because he began to deviate from the pattern.

      I've been on the Uberman cycle for about ~95 days now, and I feel great. I've average about 3.5 hours of sleep a day, and I realy feel as refreshed as I used to be after a 10 hour sleep-fest.
      I highly recommend it to anyone who is willing to
      ..Hccchhhh.............zZZZZZzzzzzzzzzzzzzzzzzzzzz zzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzz

    6. Re:caffene crash is great by Wonko42 · · Score: 3, Informative

      With Uberman's cycle, you end up getting more REM sleep every day than you would with 8 hours of consecutive sleep. Your brain learns to drop into REM sleep immediately, so each 20-30 minute nap is entirely REM, which adds up to between 2 and 3 hours of purely REM sleep per day, which is more than enough.

    7. Re:caffene crash is great by lukesl · · Score: 2, Informative

      The Uberman sleep cycle thing is complete bullshit. There have been numerous REM deprivation studies done in animals, and what your brain and body really need is stage 4 sleep, not REM. REM is the lightest part of sleep, and stage 4 is the deepest. I'm a narcoleptic MD/PhD student studying neurophysiology, so I know a little about this stuff. If you want to be more efficient with your sleep, don't sleep more than four hours at a time. EEG studies have shown that four hours is about the optimum length of time for sleep, and it becomes much less efficient after that. So if you can sleep for two four-hour periods per day, you are in very good shape. There are multiple lines of evidence supporting the fact that Homo sapiens in "nature" slept twice a day, including a periodic body temperature changes with a 12 hour period (you're always sleepier when your body temp. is just past its peak, IIRC). Most people get very tired after lunch--this is not a coincidence. Note that in many cultures, this is the sleeping pattern people have (e.g. the Siesta).

      No one really knows for sure why all animals sleep (down to fruit flies and earthworms), especially since one would think it would be strongly selected against, evolutionarily speaking. The fact that we spend 1/3 of our day defenseless shows just how important sleep is (that and the fact that sleep deprivation is fatal in all organisms from humans down to fruit flies). Interestingly, even birds that fly for days on end or whales that have to swim to the surface to breathe still sleep. However, their brains are capable of sleeping one hemisphere at a time! Another interesting/random fact is that hibernation is different than sleep because at least some animals that hibernate wake up out of their hibernation periodically and sleep for a day, then wake up again and hibernate some more. Apparently the hibernation and sleep are distinguishable by EEG (recording "brain waves" by scalp electrode). Most evidence points towards sleep's most important role being in consolidation of memory in cortex (and probably general homeostasis of neurons). People used to think this occurred during REM, but now it sounds more like this is occurring during different stages of sleep, while REM is more like a waking state where information is filtered and organized and prepared for consolidation in deeper stages of sleep. Your conscious perception of these processes occurring is called "dreams," BTW, and contrary to common belief, they do not happen exclusively during REM sleep. The reason why we need "sleep," a period of inactivity, is apparently because there simply isn't a way to perform certain tasks of homestasis, synaptic strength updating, etc. while the network is functional. This makes sense if you think about it, and apparently there's some interesting data supporting. Destexhe and Sejnowski have a book about some of this stuff, and I think they argue that pyramidal cells in cortex receive synchronous excitatory and inhibitory inputs from the intralaminar nuclei and reticular nucleus, respectively. Both of those are parts of the thalamus, a structure in the middle of the brain that sends some projections out to the cortex, or the layers of cells on the surface. Anyway, the excitatory input activates NMDA receptors and voltage-gated calcium channels in the dendrites, while the inhibitory input shunts the depolarization, preventing firing of action potentials. The dendrite therefore fills with calcium, activating various pathways involved in synaptic plasticity, etc.

      But I digress. The point is, sleep is important, and just because there is a drug out there that can fool your brain into thinking it doesn't need sleep, it still does. Forced sleep deprivation, in time, has been shown to cause permanent brain damage and eventually death. Taking a drug like provigil will most likely not prevent these things from happening--it will only prevent you from knowing that these things are happening. Another thing is that some people will say that scientists don't know how provigil works. This is partly true. There was a paper in Cell (I think) a couple years ago demonstrating that provigil (also called modafinil) increases firing in cells expressing a certain receptor for hypocretin/orexin, this short peptide neurotransmitter that regulates various aspects of wakefulness and hunger. The neurons that make that stuff were recently shown to be the ones that mysteriously die in narcoleptic patients. However, we don't know the exact mechanism by which the provigil affects these cells. IIRC, the provigil doesn't interact directly with the receptor, but nonspecifically intercalates into the membranes and does who-knows-what, with one end result being increased firing rate in cells expressing the proper receptors. However, this drug is not some sort of high-specificity compound that was rationally designed or found by interaction with a known target like most of the new drugs coming out on the market. It may have many side effects that are not documented. I took it for several months, and it made me extremely stupid. I became severely depressed and was driven almost to suicide. I would just sit on the floor and cry, babbling that I used to be smart and I didn't know what was happening to me. The disturbing thing was that I somehow didn't realize that it was the drug doing it to me. Once my girlfriend figured this out and got me to stop taking it, I was fine. When I looked into it a little more, I found that there were a few people in narcolepsy support groups who had similar side effects, despite the fact that these were not reported during clinical trials (and therefore, my doctors had a hard time believing that they were real). In summary, stay away from provigil unless you need it. For the people it works for, it's a miracle drug, but it is a very serious drug, not just a caffeine pill.

    8. Re:caffene crash is great by eam · · Score: 2

      > The reason why we need "sleep," a period of
      > inactivity, is apparently because there simply
      > isn't a way to perform certain tasks of
      > homestasis, synaptic strength updating, etc.
      > while the network is functional.

      Sounds like a stand-alone backup under VMS. Reboot standalone, do a backup of the idle system disk, reboot...I wonder if my VAXen enjoyed their dreams.

  3. Seriously by crumbz · · Score: 4, Funny

    What would happen if you took this with an Ambien, a couple of beers, a Tylenol-3 and a grande mocha? I think you would time travel...

    1. Re:Seriously by Indras · · Score: 3, Funny

      I think you would time travel...

      Yeah, in a "whoa, is it really August already?" kind of way.

      --
      The speed of time is one second per second.
    2. Re:Seriously by JZ_Tonka · · Score: 2, Funny

      I'm sure the guys at ThinkGeek.com could find a way to sell that.

    3. Re:Seriously by 56ker · · Score: 2

      And there was me taking you seriously for a while! Really I must cut back on the caffeine!

    4. Re:Seriously by chainsaw1 · · Score: 2, Funny

      I'm more concerned with just being able to sleep at night. I used to be able to say i'm not in the mood, but Viagra kill that one. The only one left was i'm too tired...

      Guess that one's gone too...

      --
      - Sig
    5. Re:Seriously by TheDarkRogue · · Score: 5, Funny

      one glass vodka, $3
      one shot nyquil (The icky green liquid stuff, not Gelcaps), $2
      two tablets nodoze, $3

      not knowing where the fuck you are, what day it is, what time it is, your name, what language your speaking, and then comming too 7 hours later and finding you wrote a web/gopher/ftp/qotd/chargen server that works, priceless

      --
      (Score:0, Interesting)
    6. Re:Seriously by kin_korn_karn · · Score: 2, Funny

      so YOU wrote xinetd?

    7. Re:Seriously by ncc74656 · · Score: 2

      Doesn't the NyQuil tend to cancel out the No-Doz? There's a reason you normally only take NyQuil at night...

      --
      20 January 2017: the End of an Error.
    8. Re:Seriously by curunir · · Score: 3, Informative

      Exstacy can make you depressed

      While it's true that Ecstacy can make you depressed, it's a bit unfair to say that depression is a side effect of the drug since there are steps one can take to prevent it.

      At one point, I considered no longer using the drug because of this very fact. However, I did some research into how the drug works and why it causes depression. Basically, you get depressed because you either have too little seratonin in your brain for it to function normally or you've damaged the seratonin receptors in your brain to the point where you no longer have a sufficient number to support normal serotonin levels.

      So, the goal is to counteract those affects in some way. In order to boost low seratonin levels, my friends and I take 5-HTP (the body's natural precursor to serotonin). This won't ensure high serotonin levels in all cases, but usually does. It's also important to maintain high levels of MAOs (monoamine oxidases IIRC...anti-oxidants...vitamin C, for example). The MAOs help your brain metabolize serotonin that is not recaptured by the receptors. If that serotonin isn't matoblized, it can cause brain damage. This is also why people taking MAOIs (the I is for inhibitors) should never take e.

      So basically, if you're going to be using e anywhere close to regularly, go down to the local pharmacy/GNC and pick up some 5-HTP and some multi-vitamins (or however you feel like loading up on anti-oxidants). I can't offer any scientific evidence that this works, but within my circle of friends (about 30-45...all of whom follow this advice), not one person has complained about depression as a side effect of e.

      Bottom line is: if you're going to do any drug, be educated about it. Read as much as you can about how it affects your body. There is a lot of misinformation on both sides of the issue, so think about the source of the information you read (i.e. trust the government about as much as the buy passed out on the floor with his face in a pool of drool).

      --
      "Don't blame me, I voted for Kodos!"
    9. Re:Seriously by JabberWokky · · Score: 2
      The only drug I know of that is safe from a physiological point of view is pot.

      FWIW, I have always noticed that you can spot a pot smoker, or even someone who used to smoke pot years ago. There are certain mannerisms and facial clues that are common among people who have smoked for awhile.

      That's enough evidence for me that there is *some* sort of effect, and a lasting one, on your body, probably your brain. You can cite all the studies proving or disproving the effect, but you can also spot it in the real world.

      I'm also quite a bit concerned with Extacy for the same reason - everybody I know who has done it about a dozen times seems to have serious depression and memory problems during the day. I can't say with as much certainty, as I've known far more pot smokers, but it's enough for me to avoid it.

      I don't like stuff that mucks with your brain. Seems to me that your body is on a track to peak and then gradually fail over many decades (I'm already on that slow glide, as my back reminds me at times), so the only thing that really remains that is *you* is your mind. And that kinda needs your brain functioning to survive.

      --
      Evan

      --
      "$30 for the One True Ring. $10 each additional ring!" -- JRR "Bob" Tolkien
    10. Re:Seriously by JabberWokky · · Score: 2
      Oh dear me, we are getting a bit boring dont you think?
      Enjoy your life, live it to the max and dont be such a wimp

      You sir, are decidely the first person to have ever told me that. :) Something about being a large man with a full beard that regularly wears lingere with his hair in pigtails, or runs around in the woods in mideval outfits singing bawdy songs, or preaches to the general public about the evils of being a Pink, standing behind a homemade Dobbshead podium... no, I haven't ever been accused of being boring or a wimp. Heh.

      Although people *have* speculated what I'd be like if I did do drugs...

      --
      Evan

      --
      "$30 for the One True Ring. $10 each additional ring!" -- JRR "Bob" Tolkien
    11. Re:Seriously by nettdata · · Score: 3, Insightful

      While it's true that Ecstacy can make you depressed, it's a bit unfair to say that depression is a side effect of the drug since there are steps one can take to prevent it.

      Wow... and I thought taking LEGAL advice from Slashdot was bad!

      --



      $0.02 (CDN)
    12. Re:Seriously by curunir · · Score: 2

      Notice the last paragraph in which I recommended being as informed as possible. No one should take my advice without first questioning what I say and confirming for themselves that it is likely to be true. People on /. are more than capable of doing web research. There's lots of information and disinformation out there.

      Bottom line is there is an inherant danger in introducing a foreign substance into your body without first knowing exactly what it is and how it is likely to affect you. Maybe I didn't make that clear in my first post. Believing everything that I said is just as naive as believing what the DEA says.

      --
      "Don't blame me, I voted for Kodos!"
  4. Wow... by MonkeyBot · · Score: 4, Funny

    If I would have had this during my undergrad career as an engineer, maybe I could have gotten a degree AND had a social life!

    1. Re:Wow... by Indras · · Score: 2

      Get a degree AND have a social life? I would think that would cause a black hole or tear the fabric of space-time or something. That's probably why it's never happened before.

      --
      The speed of time is one second per second.
  5. It won't replace coffee. by Hiro+Antagonist · · Score: 4, Insightful

    There's something incredibly cozy about having a cup of hot coffee or tea to sip on throughout the day, a sort of tangibility that you won't get from popping a pill. It's kind of like the difference between muzak(tm) and Pink Floyd...sure, both are music, but only one is music.

    --

    --
    I Hit the Karma Cap, and All I Got Was This Lousy .sig.
    1. Re:It won't replace coffee. by Bryan+Andersen · · Score: 2

      Do both. One can still have the cup of coffee or tea. This just allows one to choose a better tasing tea without having to select for caffein content. This also opens up a hole slew of other better tasting beverages that are sans caffein.

    2. Re:It won't replace coffee. by Phexro · · Score: 2

      "This just allows one to choose a better tasing tea without having to select for caffein content."

      Might I suggest Good Earth teas? Their Black tea is the strongest, with Green tea in second place. The Green tea tastes better than Black, and still has enough caffiene to get me going. It's also not nearly as hard on my digestive system as coffee.

      It is more expensive, but don't let that fool you. I've saved quite a bit of cash since I switched, since I no longer eat three tins of Altoids a day for my creature-from-the-black-coffee-lagoon breath.

    3. Re:It won't replace coffee. by Xerithane · · Score: 2

      Call me a whore, but I am rather fond of the Starbucks Tazo teas. Their Chai and Black tea (dubbed 'Awake') are really quite good. Since I switched to drinking only tea, and got off caffeine other than when I am craving the taste of the beverage I feel a lot better.

      Drinking tea vs. hyped-up-overcost-insulting-italians-grande-no-foa m-extra-whip-non-fat-soy-coffee will save you a helluva lot of money.

      $5 for the coffee, vs. $1.15 for the tea that you can refill for free till your bag goes dead...

      As for the altoids, have you tried those Listerine strips? W0000...

      --
      Dacels Jewelers can't be trusted.
    4. Re:It won't replace coffee. by edrugtrader · · Score: 3, Funny

      is this one of those advertising bots???

      NO! i don't want starbucks OR listerine strips, now stop posting!!

      --
      MARIJUANA, SHROOMS, X: ONLINE?! - E
    5. Re:It won't replace coffee. by Peyna · · Score: 2

      I wouldn't recommend doing both. Caffeine may interact with the drug in interesting ways, and I wouldn't recommend trying it out unless studies have been done.

      An interesting note along these line, I ran across some articles a couple of weeks about deaths related to 'energy drinks' (high-caffeine, etc.) when taken with alcohol or strenuous exercise.

      --
      What?
    6. Re:It won't replace coffee. by jonbrewer · · Score: 3, Insightful

      RedBull and Vodka is quite a popular drink, though the name of it slips my mind at the moment.

    7. Re:It won't replace coffee. by Pathwalker · · Score: 2

      Hmmm - looks interesting, but all of their tea is bagged.

      Lately I've switched to buying loose lea. I find that it is usually cheaper (less processing) and better quality (it has to be whole leaves so it won't pass through the strainer).

      I've been buying mine from Stash Tea and I've been happy with what I get.
      I usually have some of their Chai Spice with me at work, with a canister of Lapsang Souchong for those high stress moments.

    8. Re:It won't replace coffee. by Peyna · · Score: 2

      I believe that is what it is called at the hospital too.

      --
      What?
    9. Re:It won't replace coffee. by Pathwalker · · Score: 2

      I used to make tea in an espresso maker to make tea all the time when I was in college (a good way to wring everything out of the leaves).

      I've used coffee makers as well but I suspect the the other people on the night shift would be a little upset if I took over the coffee maker.

      Besides, I like the little silver ball I use as an infuser. It's shiny!

      Plus, I just drop it in my mug at the beginning of the 12 hour shift, and top off with hot water throughout the night until my tea no longer tastes like tea. Then I just refill the ball, and repeat...

    10. Re:It won't replace coffee. by spike+hay · · Score: 2

      This does sound like a great drug for many people. But I think I'll stick with caffeine. For people w/o a heart condition it's perfectly safe. And it works astonishingly well. (Unless you chug down a lot of caffeine. That will cause you to be wired for a few hours and then crash)

      One thing I like about caffeine is the delectible means of delivery. A hot cup of coffee or a refreshing iced tea is much more pleasurable than a pill any day.

      Also, caffeine has another benefit, at least for me. It helps me control my depression. Last year, I didn't drink much caffeine, and I had a horrible depression. Caffeine seems to calm my depression somewhat. Whenever I feel depressed, I reach for the coffee or iced tea. About a half an hour later when it takes effect, my depression is reduced.

      This works because caffeine manipulates dopamine production. It produces increased levels of dopamine, your body's happy neurotransmitter. It does the same thing as pot or alcohol, just to a lesser degree. This curbs my depression.

      Of course when you come off of caffeine, it is horrible. When I have gone though withdrawal before, my depression comes back worse than before, I'm tired, and I'm completely pissed off, not to mention getting crushing headache. Of course that is prevented by drinking caffeine every day. I'd rather be addicted to caffeine than go though the hell of depression again.

      I am one of those people who gets up early. I get up at 4:30. I get to sleep somewhere around midnight. So I get about 4 1/2 hours of sleep a night. Much less than the usual 6-9 hours recommended.

      Despite getting little sleep, I function perfectly well with my pleasantly bitter friends: coffee and iced tea. I am a high school sophomore. Even though I get little sleep, this year I am still running with about a 3.9 GPA. All of this is thanks to caffeine.

      In the morning, if it is wintertime, I usualy imbibe two 20 oz. cups of strong black coffee. (I like it black, like my women) In the spring or summer, I drink about two quarts of iced tea. Dammit I love iced tea. I'm drinking a glass right now. Anyway, I've got a C++ programming class first period, and there is no way in hell I would be able to code well at 7:50 A.M. without my caffeine.

      Then, 3rd period, my science teacher gives out coffee. He believes it helps us focus better, which it does. I get recharged from a good 16 OZ. cup in his class.

      By the end of the day, I begin to crash. But then I have toning (gym) class. The physical exercise gets me alert again. Then, I get home, and enjoy another tall glass of strong iced tea.

      As for the health problems of me drinking a lot of caffeine: I don't believe it is causing a big problem. I have a resting heart rate of 58 Beats Per Minute. Most people my age group are around 70 BPM. So I don't have tachycardia or anything. My blood pressure, the last time I checked, is 95/55. I can also run a mile in 5:30, so I am somewhat physically fit. The only reason I could see for someone avoiding caffeine is if they have a heart problem. Then, the higher heart rates and blood pressure brought on by caffeine is not so good.

      Now, an unhealthy way of getting your caffeine is to drink pop. Pop contains quite a few empty calories. It also has an ingredient that depletes your bone density. I stopped drinking pop 2 years ago. I have no desire to start again. Now that I have been off it for a while, I just think pop is sickeningly oversweet. It's easy to kick the pop habit. Just refrain from drinking pop for a month or so and you should have no desire for it anymore. The junk food habit is not too hard to kick either. I don't eat any junk food such as potato chips anymore like I used to.

      --
      If you don't understand any of my sayings, come to me in private and I shall take you in my German mouth.
  6. Sleep and dreams... by Steveftoth · · Score: 5, Interesting

    Since this deprives you of sleep, but somehow keeps you from falling asleep, the long-term side effects of this are compeletly unknown. All the studies show that not sleeping is extreamly bad for you in the long run. Lowers immune systems, increases stress, reduces hapiness, etc.
    One thing they don't mention is if you have to sleep for a 'normal' amount after the drug wares off. So if you are awake for like 36 hours, then how long do you sleep? 8 hours? or 16 hours?

    Even if this has bad long term effects, this will be very popular, everyone has those nights that they 'have' to stay up and work. Could be the procrationators drug of choice.

    1. Re:Sleep and dreams... by axlrosen · · Score: 3, Insightful

      All the studies show that not sleeping is extreamly bad for you in the long run.

      I don't think that this is true. I read a New Yorker article a few months ago about the same drug. It said that not getting enough sleep will impair your performance at the time, but it doesn't cause any long-term effects. It talked about Randy Gardner who stayed awake for 11 days straight. He didn't experience any real problems during the experiment, and was completely back to normal after sleeping for something like 14 hours after the experiment.

      And the really interesting thing about this new drug is that you can stay awake for long periods of time without any performance impairment, or even any sleepiness. Cool and scary at the same time...

    2. Re:Sleep and Dreams... by Fixer · · Score: 2, Interesting
      And in some situations that could be a blessing in disguise. 40 hour military mission, bloody results, file a report go to sleep and forget about it.

      I could see this as a boon for engaging in scut work that's just complicated enough that I can't let my mind wander, but boring enough so that I wouldn't want to remember it.

      --
      "Avast! Prepare for the rodgering!" THWACK! "Arrr.. me nards.."
    3. Re:Sleep and dreams... by RevAaron · · Score: 2

      Actually, I've read a study or two that suggests that you can have a debt of sleep, that can be repaid, eventually bringing you to a 7.5-8 hour/night pattern.

      --

      Working toward a usable PDA environment in the spirit of Newton OS: Dynapad
    4. Re:Sleep and dreams... by Brigadier · · Score: 3, Funny

      This is true once I took thee vivrin and 4 bottles of caffinated water to finish a project while in school persuing architecture. I started friday and worked through the entire weekend, no sleep. I handed in my project thank God it was a silent crit, went home and slept at 11am, then woke up 9:30 wednesday morning. I would never do it again, but the level of creativity I attained on that project I have never been able to reach again. I guess there is much to be said for vivrin, caffinated water, and marker fumes huh.

    5. Re:Sleep and dreams... by i_am_nitrogen · · Score: 2

      If that's the case I must be WAY overdrawn...

    6. Re:Sleep and dreams... by spike+hay · · Score: 2

      For an animal to risk their lives by shutting down and being almost totally vulnerable for 8 or so hours a day and for sleep to have survived evolution for so long and amoung so many different species of animals means it must be pretty damn important.

      Yeah. I agree. I've heard before that REM sleep is kind of the brain's daily cleaning of unwanted noise and short-term memory. Also, when food is in short supply, sleeping might still be an evolutionary advantage. If not much is going on, sleep makes sense. It conserves valuable calories because your metabolism is reduced quite a bit. That's why lions sleep 20 hours a day.

      --
      If you don't understand any of my sayings, come to me in private and I shall take you in my German mouth.
    7. Re:Sleep and dreams... by spike+hay · · Score: 2

      May I all point you to a study done a few months ago that points to 6 hours a night being optimal.

      This was a study of 1.1 million people over 6 years. It should be accurate. It showed, contrary to popular belief, that those who got 8 or more hours tended to die a little younger than those who got 6 or 7.

      Also, it you get less sleep, in effect you are living longer.If you sleep 6 instead of 8, you get 2 more hours each day. That adds up to several years over your life, in effect.

      I feel very refreshed with 6 hours of sleep. 8 hours makes me feel groggy.

      --
      If you don't understand any of my sayings, come to me in private and I shall take you in my German mouth.
    8. Re:Sleep and dreams... by RevAaron · · Score: 2

      Heh, better pay up foo!

      --

      Working toward a usable PDA environment in the spirit of Newton OS: Dynapad
    9. Re:Sleep and dreams... by Skip666Kent · · Score: 2

      Nope. Sleep deprivation (lack of REM level sleep specifically) leads to hallucinations (NOT the fun kind) and eventual nervous breakdown and death. It wasn't/isn't used as a form of torture because it's pleasant and good for you. If this drug counteracts this somehow I'll be very suprised and very interested...and very skeptical. There's got to be some form of short-term or long-term payback somewhere along the line.

      --
      **>>BELCH
    10. Re:Sleep and dreams... by Kintanon · · Score: 2

      Sleep is incredibly inconvenient. It requires that I spend an unnecessarily long time unconcious when I could be doing other things.

      Kintanon

      --
      Check out JoshJitsu.info for Brazilian Ji
  7. WARNING! No one knows how it works!!! by toupsie · · Score: 4, Insightful
    From the article:
    Provigil was developed in France in the 1970s. Although no one is sure how it works, animal studies show that the medication--unlike other drugs that induce wakefulness--doesn't seem to dramatically increase levels of dopamine, a neurotransmitter associated with arousal and alertness.

    If you want to take a drug that no one knows how it works, go for it. However, I will not be taking a drug that scientists are clueless about.

    The best treatment for sleepiness is SLEEPING!!! If you are engaging in an activity that is depriving you of sleep, STOP!!! There is a reason you get sleepy. Your body and mind needs to rest and recharge and sleepiness is the signal to do so. Medical test after medical test has shown that people that deprive themselves of sleep go insane and lose their ability to perform even the easiest of tasks. That is why sleep deprivation is used so often as a torture device to break down subjects, so they will spill the proverbial beans.

    --
    Strange women lying in ponds distributing swords is no basis for a system of government.
    1. Re:WARNING! No one knows how it works!!! by startled · · Score: 2

      If you want to take a drug that no one knows how it works, go for it. However, I will not be taking a drug that scientists are clueless about.

      Exactly. Now's your chance to get ahead of the curve, while normal people (see above) are worried about "long term effects" and other such nonsense. Once it's certified healthy, we're back to square one with heightened expectations, when everyone's using it. So don't delay-- start using it now, and get 10 years up on everyone else!

    2. Re:WARNING! No one knows how it works!!! by Nilatir · · Score: 2, Informative

      Hate to break it to you but if you check out www.rxlist.com you'll find that doctors and scientists don't really know how a lot of drugs work.

      --

      "We were half way to Rivendell when the drugs began to take hold."
      -- Hunter S. Tolkien
    3. Re:WARNING! No one knows how it works!!! by t0qer · · Score: 5, Funny

      Medical test after medical test has shown that people that deprive themselves of sleep go insane and lose their ability to perform even the easiest of tasks.

      Lol, I got an insanity story to tell...

      When I was 18, I worked construction down in bakersfield. Everyday my boss would give me a little bit of krank to stick in my gums. I honestly didn't know what I was getting into as I had never done it before.

      After a week of no sleep, drinking pint's of whiskey like they were soda pops, and various hallucinations. I decided it would be a *Good Thing* to take on my friends 350lb father with my 150lb kranked out self.

      Lucky for me, all he did was throw me 30 feet to which, I landed on my feet, ran across the street and started yelling, "C'mon you pussy come on this side of the street i'll kick your ass!" After that episode I went home, slept for 28 hours, and vowed never to do that shit again. Haven't touched the stuff since.

    4. Re:WARNING! No one knows how it works!!! by Carmody · · Score: 2

      The best treatment for sleepiness is SLEEPING!!! If you are engaging in an activity that is depriving you of sleep, STOP!!! There is a reason you get sleepy.

      This was modded as "insightful." And I agree.

      But isn't it pathetic and sad we (or at least I) have gotten to the point where a statement like "The best treatment for sleepiness is sleeping" is now insightful.

      Good point, toup. Thank you for the remind.

      --
      God is real unless declared integer
    5. Re:WARNING! No one knows how it works!!! by Macrobat · · Score: 2
      The best treatment for sleepiness is SLEEPING!!! If you are engaging in an activity that is depriving you of sleep, STOP!!! There is a reason you get sleepy.
      Thank you, doctor, but if you will take the time to read the article, it said it is indicated for "diagnosed medical conditions." Feeling sleepy because you have missed sleep is not a medical condition. Feeling perpetually sleepy regardless of diet, exercise, or number of hours slept is. I do not know if this is being tested as a treatment for Chronic Fatigue Syndrome or not, but people who suffer from that can sleep up to 20 hours and still feel wiped out. (And, in anticipation of the geniuses who will respond by saying "oversleep makes you tired, too," people who suffer from CFS also feel exhausted after eight, ten, twelve, or three hours of sleep as well.)

      As to your point about nobody knowing how a drug works, well...too many other people have already rebutted that.

      --
      "Hardly used" will not fetch you a better price for your brain.
    6. Re:WARNING! No one knows how it works!!! by Alien54 · · Score: 2
      It is not unusual for a drug to be approved by the FDA, even when scientists (read: the drug company) does not know its mechanism of action.

      heck, there was a recent Duke university study, where if you looked closely into the results, placebos did better than the standard psych drug for treatments

      This was a study into the effectiveness of St. John's wort and they were using a placebo and a standard med for comparison.

      Drug companies get all kinds of things approved all the time. Doesn't mean that they know what they are doing besides running a profit.

      --
      "It is a greater offense to steal men's labor, than their clothes"
    7. Re:WARNING! No one knows how it works!!! by Tattva · · Score: 2
      There is a reason you get sleepy. Your body and mind needs to rest and recharge and sleepiness is the signal to do so.

      You make this claim as if it were intuitively obvious, but please let me argue that it may be wrong.

      There are other possible reasons we sleep, for example it may be because we are day hunters and we would just be using excessive calories if our bodies were at full burn 24 hrs/day. Sleep may be nothing but a food conservation program built into our evolution. Lions sleep a huge number of hours a day, probably because not burning calories when you aren't hunting for a huge calorie glut of a meal is the best strategy for surviving lean times. Some (all?) bears hibernate, probably for the same reason.

      So while you may be right, I think it is wrong to say sleep is a given and that's the end of it. Pregnancy used to be a given if you had sex, and while there are many people who still believe the only natural motivation and consequence of sex is procreation, many people now separate the two activities. I think Tiredness and Sleep may someday be separated in the same way. Sleep can be fun, but so can other things with which sleep can interfere.

      --
      personal attacks hurt, especially when deserved
    8. Re:WARNING! No one knows how it works!!! by sigwinch · · Score: 3, Insightful
      If you want to take a drug that no one knows how it works, go for it. However, I will not be taking a drug that scientists are clueless about.
      The primary mode of action of many drugs is unknown. (In fact, nobody has been able to explain how a single general anesthetic works!)

      And that's the good part: side effects are almost completely unknown. They're found by administering the drug and seeing what happens. Sometimes there are no side effects, sometimes you get a dry mouth, sometimes your fingernails fall off, sometimes all your mitochondria die, etc. There's a reason drug trials are carefully planned and monitored.

      There is a reason you get sleepy. Your body and mind needs to rest and recharge and sleepiness is the signal to do so.
      Completely wrong. There are some people who *never* sleep, yet do not suffer from bad effects. If the need for sleep where a fundamental characteristic of higher neural activity, they would die in childhood, but they do not.

      It is entirely possible (and I would say likely) that sleep is caused by a clock mechanism that tries to modulate consciousness. It is plausible that the "turn off" signal from the clock becomes hyperactive if it isn't satisfied and wreaks havoc on the rest of the brain, which is perfectly capable of staying online. If you could block or reset this hypothetical clock with a drug, you could stay awake forever.

      --

      --
      Kuro5hin.org: where the good times never end. ;-)

    9. Re:WARNING! No one knows how it works!!! by Shiny+Metal+S. · · Score: 3, Funny

      The best treatment for sleepiness is SLEEPING!!! If you are engaging in an activity that is depriving you of sleep, STOP!!! There is a reason you get sleepy. Your body and mind needs to rest and recharge and sleepiness is the signal to do so.

      This is a Microsoft attitude. Like one Microsoft support guy once said: "Memory is like gasoline - you use it up, then your computer has to fill up the tank again by restarting." This is mostly the same reasoning which you use in your pro-sleep argument, but I think that when you need sleep after so short uptime like 18 hours or so, then it means you have some serious problems with your mind getting unstable very quickly. Remember, rebooting is not an answer. Real hackers fix their systems and don't have to reset them any more. Please, stop listening to that Microsoft anti-GPL FUD propaganda, for God's sake!

      --

      ~shiny
      WILL HACK FOR $$$

    10. Re:WARNING! No one knows how it works!!! by toupsie · · Score: 2

      I am a master of the obvious. It is unfortunate that many in our society are oblivious to the obvious. Thus the need for Lawyers.

      --
      Strange women lying in ponds distributing swords is no basis for a system of government.
    11. Re:WARNING! No one knows how it works!!! by Graspee_Leemoor · · Score: 2

      "heck, there was a recent Duke university study [radiofreenation.net], where if you looked closely into the results, placebos did better than the standard psych drug for treatments"

      That's because the scientists had all been experimenting with different sleeping habits and fallen asleep, so the lemurs took over and ran the experiment for them.

      Unfortunately, lemurs do NOT make good scientists- they tend to be distracted by bright shiny things and stuff that tastes good or moves in an interesting way.

      Basically they got as far as putting on the lab coats (which were absurdly big on them- much amusement all round), then they got so into the clipboards and pencils that they forgot about running the experiment altogether.

      When the scientists woke up, they were a bit confused, saw the lemurs' scribblings on the charts and assumed the experiment had been run and it was all ok.

      Hence the somewhat peculiar results...

      graspee

    12. Re:WARNING! No one knows how it works!!! by toupsie · · Score: 2

      I don't take any drugs for medicinal reasons outside of a multivitamin everyday. I have been blessed with practically a disease and injury free life. My father is a doctor and I have realized that if you stay away from doctor's offices, you stay healthier. All the sick people hang out there.

      --
      Strange women lying in ponds distributing swords is no basis for a system of government.
    13. Re:WARNING! No one knows how it works!!! by jafuser · · Score: 2
      The best treatment for sleepiness is SLEEPING!!!

      Nice oversimplification. There are people who have a much more complicated problem than you assume. I regularly get 10-12 hours of sleep a night, and I still feel like sleeping all day, especially around 2-4 in the afternoon. I have to do everything to keep myself awake: drink coffee, walk around the office, listen to loud music on my headphones, take a break outside in the sunlight, etc. My commute home at the end of the workday is often a battle to stay awake while driving. Then I get home and sleep until about midnight. I spend a couple of hours of free time and finally go back to sleep for another 4-6 hours before going back to work.

      Just what am I supposed to do? If I did what my body is telling me, I'd probably sleep 18 hours of the day. I'd love to give this a try, but I don't really have narcolepsy, as I am able to stay awake, though sometimes the effort to do so is quite substantial. I'm willing to spend whatever it takes to be able to live a normal life like everyone else and feel at least marginally awake for the entire daylight period. I'd like to have more free time and be able to get away with sleeping less, but whenever I do, I wind up in sleep debt, and I usually wind up sleeping all weekend as well...

      PS: I tried looking around online for anyone who sold this, maybe just to try it, but it seems to elude my search capabilities.

      --
      Please consider making an automatic monthly recurring donation to the EFF
    14. Re:WARNING! No one knows how it works!!! by Zathrus · · Score: 2

      Ever heard of narcolepsy? It's a medical disorder where you fall asleep all the time during the day, regardless of how much sleep you've already gotten. Varies from mild (merely drowsy) to severe (sudden, unavoidable episodes of sleep with little or no warning).

      I have it. I'm on Provigil too. I got on it as soon as it was FDA approved. Why? Because the most common prescription for narcolepsy prior to Provigil was Ridalin. Yeah, the same thing they give to treat ADD. It's also a narcotic and addictive.

      Provigil doesn't work perfectly for me - I take a 200 mg pill in the morning and usually wind up sleepy in the afternoon - but it works a helluva lot better than Ridalin, isn't addictive (as best the medical industry can tell), and it lets me actually do work rather than falling asleep constantly. Lets me do things like drive safely too. And I only have "moderate" narcolepsy - I know when I'm getting tired, but I'll go to sleep for 15-30 minutes whenever possible. And without treatment it's impossible for me not to.

      The fact of the matter is, nobody knows exactly why we sleep, what we need it for, or why some people have sleeping problems (narcolepsy and insomnia). Expecting to know why a drug works when you don't know why the symptoms exist is hopeless. At best you can hope that finding a drug that treats the symptoms will let you figure them both out.

    15. Re:WARNING! No one knows how it works!!! by toupsie · · Score: 2
      The fact of the matter is, nobody knows exactly why we sleep, what we need it for, or why some people have sleeping problems (narcolepsy and insomnia). Expecting to know why a drug works when you don't know why the symptoms exist is hopeless. At best you can hope that finding a drug that treats the symptoms will let you figure them both out.

      That is why I said it was fine if you want to take it but I will not. Reread what I said. I never said "DON'T TAKE PROVIGIL!". I said:

      If you want to take a drug that no one knows how it works, go for it. However, I will not be taking a drug that scientists are clueless about.

      Seems that several people only read the last sentence and not the first.

      --
      Strange women lying in ponds distributing swords is no basis for a system of government.
    16. Re:WARNING! No one knows how it works!!! by Zathrus · · Score: 2

      I would suggest that you do have narcolepsy or chronic fatigue syndrome, just a very mild case of it.

      Read some of my other posts on this thread - I have narcolepsy and am on provigil. I can stay awake through some bouts of sleepiness, but not all. And I have what is considered "moderate" narcolepsy.

      Talk to your doctor, get a referral to a sleep clinic. Trust me, it's worth it.

    17. Re:WARNING! No one knows how it works!!! by toupsie · · Score: 2
      Yes, you should know about what medicines you are taking. You should make an informed decision on whether or not that medicine is the best thing for your circumstances. But the blanket statement you made was, well, silly.

      I think you should re-read what I said before making blanket statements about my comments. I said to "go for it" if you wanted to take a medicine that scientists are clueless about. However, I will avoid it. So I don't see how it is silly for me to tell you to make your own decisions and use the drug if you want but I will not be using it. Seems to be a pretty darn reasonable statement.

      Here is the statement:

      If you want to take a drug that no one knows how it works, go for it. However, I will not be taking a drug that scientists are clueless about.

      --
      Strange women lying in ponds distributing swords is no basis for a system of government.
  8. I do cocaine.... by teamhasnoi · · Score: 4, Funny
    so I can work more, so I can make more money, so I can do more coke, so I can work more, so I can make more money, so I can do more coke, so I can work more, so I can make more money, so I can do more coke,so I can work more, so I can make more money, so I can do more coke,so I can work more, so I can make more money, so I can do more coke.....

    ....I'm always chasing rainbows...

  9. or you can do what Edison and Da Vinci did by levl289 · · Score: 3, Funny

    sleep 2 hours a day and feel great

    I'm REALLY curious about trying that new sleep pattern, but oddly enough, I don't have the time to try it!

    --

    Q: What do you think about American Culture?
    A: I think it's a good idea.
    (adapted from Gandhi)

    1. Re:or you can do what Edison and Da Vinci did by geekoid · · Score: 2

      true, but howmany thing do you do that you can't get away from for 20 minutes?
      He talks about a D&D game, but why could he have said, ok, where going to take a 25 minute break, then resume?
      After 4 hours of work, most people get(at least) a 30 minute break.
      not to imply that its easy to do, but his excuses seemed a little lame to me.
      Of course this is the same guy that went out drinking befor trying his new sleep schedule.
      "....you know, morons."

      --
      The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
    2. Re:or you can do what Edison and Da Vinci did by Sc00ter · · Score: 2
      There was a Story on K5 about this exact thing.

      And why was this modded as funny? it's a real sleep pattern that people use.

    3. Re:or you can do what Edison and Da Vinci did by Shaheen · · Score: 2

      My friend did this our freshman year of college right before finals week.

      At one point, he crashed for an entire 4 hour block, and then, he fell asleep DURING our physics final!

      If you're not already accustomed to the schedule, I would doubt it's a good thing to try just before a critical time of your daily life.

      --
      You should never take life too seriously - You'll never get out of it alive.
  10. It's sad... by Lizard_King · · Score: 3, Insightful

    ...to see how people underestimate the value of a good night's sleep to your health. I'd rather get a little less done during the day than deal with the whole laundry list of problems you are opening yourself up to when you are sleep deprived. Ever notice that people who don't get much sleep get sick a lot?

    Sleep is fundamental, period. There are no substitutions.

    --
    "My mother never saw the irony in calling me a son-of-a-bitch." - Jack Nicholson
    1. Re:It's sad... by fishebulb · · Score: 2

      thats the entire purpose of this pill, it may not be fundamental anymore.

      If (big if there), it is doing the chemical equiv of sleep in your body, then it is effectively SLEEP.

      we'll just have to wait and see though

    2. Re:It's sad... by Dixie_Flatline · · Score: 2

      Well, there are also people in the population medically known as 'non-somniacs'. They require sleep as well, but only 2 or 3 hours every couple of days (though, of course, it varies from person to person). They're generally healthy people, they just have a massively reduced need for sleep. And when they sleep, they get up and feel refreshed (or as refreshed as anyone does when they first wake up. :)

      So, sleep isn't as fundamental as all that, I think. We really just don't understand it very well.

      That said, I LIKE sleeping. Humans have done a lot to make sure that sleeping is a pleasurable experience. I have a nice bed, nice sheets, nice blankets and fluffy pillows. I don't think I really want to give that up.

  11. Is this wise? by FurryFeet · · Score: 3, Insightful

    Sleepiness is your body's way of telling you it needs rest (basically, your brain needs rest). Using drugs to avoid it strikes me as foolish, like using analgesics to ignore the pain of a broken bone (as opposed to curing it).
    If you're sleepy, you need to sleep. If you're sleepy during the day, well, maybe you need to go to bed earlier.
    Plus, sleeping is one of the seven capital pleasures of being human. Going to bed when you're sleepy is actually pretty nice. Why give it up?

    1. Re:Is this wise? by FurryFeet · · Score: 2

      The seven capital pleasures, according to The Rape of the APE , a not really so good, but funny and at times insightful book, are: Eating, Drinking, Peeing, Shitting, Sleeping, Fucking and Playing. That part of the book, at least, made sense to me.
      Sorry for the obscure reference.
      And regarding the dimwit with the bone remark, I know you don't "cure" a broken bone. My point is clear anyway, and you either a) weren't able to understand it, or b) chose to disregard it in order to insult me. Either way, you are, as I stated, a dimwit. With all due respect, and all of that.

  12. Anyone remember the water cooler experiment? by t0qer · · Score: 2

    IIRC there was an experiment where a factory secretly "spiked" the water cooler with pure caffiene goodness. It produced a whopping 15% in productivity amongst the workers.

    I can see the drugs manufactuer now going through trial test.

    Hi we'd like to spike your water coolers with a new drug we've developed

    I think it's against the law to put anything other than water in those things

    This new drug is *Better* than caffiene. It should increase worker production up to 25%!

    That sounds great! Where do we sign up?

    1. Re:Anyone remember the water cooler experiment? by Tattva · · Score: 2
      IIRC there was an experiment where a factory secretly "spiked" the water cooler with pure caffiene goodness.

      That seems unlikely. I've never tasted pure caffeine, but I have read that it is quite bitter. You would think someone would notice that the water tasted a little "off."

      --
      personal attacks hurt, especially when deserved
    2. Re:Anyone remember the water cooler experiment? by t · · Score: 2, Informative

      And what the reply was trying to say is that it would be like adding salt to the water. You would clearly notice the taste since caffiene is quite bitter.

  13. Re:Until Then... by The+Wing+Lover · · Score: 2

    It is somewhat telling that you consider 6 hours to be a good sleep.

    --

    - In Capitalist America, law violates YOU!

  14. As with all good things... by SkyLeach · · Score: 3, Interesting

    This will have horrible side effects. When will people learn that there is simply no substitute for a good night's sleep.

    Even natural stuff like gensing makes you feel like pure total SH*T when it wears off. Does funky things to yer pee to...

    My dad is a hard-line baptist, will not drink ANYTHING with alcohol (or even anything that looks like alcohol, i.e. IBC Root Beer and Welches sparkling grape juice) but drinks up to 5 pots of coffee a day.

    He gets kinds irate when I point out he's addicted, but...

    --
    My $0.02 will always be worth more than your â0.02, so :-p
    1. Re:As with all good things... by Walter+Wart · · Score: 2, Informative

      Several people have already pointed out that "natural" doesn't mean "good for you". Perhaps a little more emphasis is in order.

      Back when I did more botany I discovered that plants produce chemicals that do two basic sorts of things:

      1)Produce more plant tissue by making food, growing, reproducing, or something of the sort

      2)Bug killer. Stuff that makes them poisonous or unpalatable to things that eat them at the macroscopic or microscopic level.

      Our favorite alkaloid - caffeine - is the second sort of chemical. We just happen to find the effects useful or pleasurable. Think about it, a bug that has its appetite suppressed and is jittery is going to eat less of you and eat that less efficiently.

      Other perfectly natural substances like oil of wormwood will eat holes in your brain because that is what makes it worth the metabolic cost to the plant to produce them. Dead bugs don't eat you if you are a plant.

      --
      The man who never alters his opinion is like the stagnant water and breeds Reptiles of the Mind -- William Blake
    2. Re:As with all good things... by Tattva · · Score: 3, Insightful
      Several people have already pointed out that "natural" doesn't mean "good for you".

      And even beyond your points, natural and good for you don't always mean in your best interest. One of the effects of receiving sufficient or excessive nutrition is that cells (and animals) tend to focus on procreating at the expense of their own lifespans. There is a fundamental biological process that kills cells faster when there is an abundance of nutrience. That means, even though malnurishment is "bad" for you, you may live longer on a carefully malnourished diet.

      This makes sense from an evolutionary standpoint because in lean times you are best served by just surviving until better times when you can procreate or help your tribe/etc in other ways. Similarly, if you are stressed and not getting enough sleep, it may mean that you are going through some other kind of negative period in which the body's best bet is simply to extend life until better times roll around. In fact, recent studies suggest that those who sleep about 6-7 hours a night live longer than those who sleep 8-10.

      Go figure.

      --
      personal attacks hurt, especially when deserved
  15. Why not try ephedrine? by teamhasnoi · · Score: 2

    If you're THAT in need of staying awake. You can stay awake for days on that stuff. Sure you feel funny, you may vomit, and there is a chance of death, but the devil you know is better than the one you don't, right? Right?

  16. We have this in the UK. It's called Pro Plus. by wackybrit · · Score: 2

    Pro Plus

    I know a few people who pop those things all the time. I can't see the point though.. they don't work for me. Red Bull all the way baby!

  17. Re:Exercise works better by GTRacer · · Score: 3, Funny
    Yes, but if you're out exercising, you're not WORKING, slacker! Get back to work!

    Signed,

    Your Boss

    GTRacer
    - There's a Dilbert in this somewhere...

    --
    Defending IP by destroying access to it? That makes sense, RIAA/MPAA. Go to the corner until you can play nice!
  18. What "interesting ethical questions"? by stuce · · Score: 5, Insightful

    Where does society get off saying what people can and can't do with their own bodies, given that they are aware of the risks (or at least aware that the risks are not known). These are not questions for the government or society to ask. These are questions for individuals to ask. "Is this a good choice for me and my body?"

    1. Re:What "interesting ethical questions"? by teamhasnoi · · Score: 2
      As long as the current state of politics is allowed to continue, society IS going to decide what you do with your body. See the reaction of the Federal Government to the recent assisted suicide decision in Oregon or the 'virtual porn' decision. Give 'em a few more years and it will be illegal to pick your nose.

      That's the business politicians are in: Manufacture laws to look useful to an apathetic non-voting public. Then they can stay in office forever, and collect a healthy retirement. (Their salary when they were in office, every year until they die.)

      Wow, huh?

    2. Re:What "interesting ethical questions"? by speek · · Score: 2

      What if, before you're allowed to work for a company, they make you take a drug test, and then make you take drugs?

      --
      First, make it work, then make it right, then make it fast, then, make it bloated!
    3. Re:What "interesting ethical questions"? by poot_rootbeer · · Score: 2


      That would be great, if every person lived in isolation, and damage that a person does to one's self doesn't affect anyone else, but that's not the world we live in.

      I don't want some stupid fuck crashing hard after a week-long stimulant binge, falling asleep behind the wheel, and killing me and my family.

    4. Re:What "interesting ethical questions"? by Don+Negro · · Score: 2

      How does the Supreme Court's decision that the government can't outlaw virtual kiddie porn support your argument?

      --

      Don Negro
      Perl 6 will give you the big knob. -- Larry Wall

    5. Re:What "interesting ethical questions"? by TheOnlyCoolTim · · Score: 2

      We allow people to drink alcohol, but we punish them if they are stupid enough to drive when they are drunk.

      Tim

      --
      Omnia vestra castrorum habetur nobis.
  19. Drink Yerba Mate by LetterJ · · Score: 2
    If you're looking for a beverage that contributes to general alertness without the jitters, nervousness, irritation and general ill health that accompanies regular coffee and tea, you should take a look at drinking yerba mate.
    • Yerbamate.com - Information and online order
    • Nativa - manufacturer, online order and general information.
    • Ma-Tea - online ordering
    • Urban Jungle Mate - Online ordering and information.
    • Guayaki - Makers of a really good mint blend and chai spiced blend.
  20. Cool! by Greyfox · · Score: 2
    I was going to get all snotty and say I'd had one of those for years in Vivarin, but this seems to avoid all the nasty side effects (Jitters... irritability... nosebleeds...) The army study had a guy go 40 hours while staying alert on this stuff. I would always crash at around 30-35 at the height of my caffiene abuse, and after about 28 everything would start getting kind of surreal.

    They got to sell this stuff over the counter. I don't care if it makes you grow a damn tail! Gimmee!

    --

    I'm trying to teach myself to set people on fire with my mind... Is it hot in here?

  21. "Beggars in Spain" is a good book about this by 512k · · Score: 2, Interesting

    in the (fictional) book, some children are genetically engineered to not need to sleep. They become superhuman, due to all the extra time they have to live life. But in real life, at what point do we say, enough is enough, we don't have to push ourselves this hard, and if we do, do we recalibrate what society expects of a person. Instead of giving your kids ritalin, give them Provigal.

    --
    ------ Work is so much easier when you don't
    1. Re:"Beggars in Spain" is a good book about this by stripes · · Score: 2
      They become superhuman, due to all the extra time they have to live life

      In the book the "sleepless" also don't age and are super smart to boot. As far as I know this drug doesn't do that... (the book, and it's sequel "Beggars and Choosers" are both really good fiction though)

  22. I've used it. by dietz · · Score: 5, Informative

    I've used it. The longest I've ever stayed up is 40 hours or so. The only noticible side effect was a slight headache, but that could've been caused by any number of things (I get headaches a fair amount because I don't eat very well :/). Headaches are the most common reported side-effect by far.

    Even after 40 hours of being awake, I was still at nearly full mental capactity and able to work, etc. I did not feel the normal symptoms of sleep deprevation at all (I've stayed awake too long many times, and I'm familiar with how it makes you feel). I did not feel high, either. I was just... awake. I also didn't feel many physical problems (sore back, sore legs, etc) like I expected to, but YMMV, of course.

    Afterwards I slept about 9 hours and had a normal next day. By my calculations (figuring you normally sleep .5 hours for each hour of wakefulness), that means I gained 22 hours of wakefulness.

    You can find them on the internet if you look around enough. I am hesitant to mention sites, but there are two in the UK that sell 100mg pills. I have been unable to find the 200mg pills. They sell for about $145 + shipping ($15 or so) for 30 pills. That's $5.33 a pill. During my 40 hours awake, I took four, which works out to about $1 per hour.

    Many people I tell this to think it would be a good idea to take them during finals. I must warn you that it's probably not a good idea because there is a very good chance your sleep schedule will get completely fucked up. For example, you may stay up for 32 hours, decide it's time for sleep, and then sleep through a final. In other words, I would take it a few times beforehand to get used to it before you decide to jump in and potentially fuck up something important.

    1. Re:I've used it. by John+Whitley · · Score: 4, Insightful

      Many people I tell this to think it would be a good idea to take them during finals.

      I never grokked why this stay-up-for-hours mentality became such a powerful meme with college students. I *always* did better by getting a reasonable amount of sleep than by staying up to cram. Give yourself a few extra days lead time for in-depth studying. Get proper sleep sleep for the period just before and during exams. Watch your performance soar.

    2. Re:I've used it. by 3ryon · · Score: 3, Informative
      I never grokked why this stay-up-for-hours mentality became such a powerful meme with college students. I *always* did better by getting a reasonable amount of sleep than by staying up to cram. Give yourself a few extra days lead time for in-depth studying. Get proper sleep sleep for the period just before and during exams. Watch your performance soar.


      There have been several important studies which show the importance of sleep on learning. If you want to do better on tests, get enough sleep.

    3. Re:I've used it. by Graspee_Leemoor · · Score: 2

      The longest I ever stayed up was 48 hours. It was when I first got Internet Access at home, and I had a free 48 hour access thing. (Yes, I knew that the 48 hours didn't have to be continuous, but I had lots of stuff to do).

      I remember chatting to people a lot, saying the most inane crap (no change there then).

      Eventually though I started hearing voices, falling asleep for very small amounts of time and waking with a bang, so went to bed.

      I have always had weird sleep cycles though; I stay up for an average of 18 hours a day, so when I get up changes by 2 hours every day. I treat this as normal, (I have been doing it for years), although everyone else thinks I am some sort of freeeeeeeek. My dad, for example, has some Victorian idea that not sleeping regular hours is unnatural and satanic.

      I do enjoy getting up early in the morning and being awake when it's light, but I just can't stay in that pattern. I will always find it difficult to go to bed because I am hacking something, playing Starcraft- whatever. ADSL doesn't help.

      graspee

    4. Re:I've used it. by tswinzig · · Score: 3, Interesting

      I never grokked why this stay-up-for-hours mentality became such a powerful meme with college students. I *always* did better by getting a reasonable amount of sleep than by staying up to cram. Give yourself a few extra days lead time for in-depth studying.

      Maybe you retain knowledge differently than most? If it's a subject that bores me, I do what most people do, I wait until the night before the exam, and cram on the topics most likely to be tested. Perhaps pulling an all-nighter if the class is early the next day.

      Procastination is a common problem. For example, I waited until the last second to post this response.

      --

      "And like that ... he's gone."
  23. You need to mix the stuff up. by MongooseCN · · Score: 4, Funny

    What happens if you mixed a pot of coffee a few liters of mountain dew and a few Provigal pills? Would you become the Kwisatz Haderach ?

  24. Re:Bandwidth by happyclam · · Score: 2

    even worse... it lets all your neighbors also stay on line round the clock

    --
    He looked at me and said, "Kid, we don't like your kind, and we're gonna send your fingerprints off to Washington."
  25. Re:Aspirin.... by evilpaul13 · · Score: 2

    I seem to recall that scientists aren't exactly sure how aspirin works either. I have no problem using it, and I also don't see a reason people can't just go the hell to bed when they are tired.

  26. One step in the right direction by YouAreFatMan · · Score: 5, Funny

    Hmm, now if I can get pills that remove my need for food, air, water, and sex, I will legally qualify as a robot.

    --
    Robotiq.com is heavily tested on animals
  27. Provigal + Viagra by bryans · · Score: 2, Funny

    Provigal extends your day, Viagra extends your performance, Now I can bonk all night long without falling asleep.

  28. looks similar to monofonil (sp?) by AssFace · · Score: 2

    and that stuff claims that you can be up for days and then after 8 hours sleep be fine again.

    yet they always seem to gloss over the fact that rats that were kept on it, if awake long enough without sleep - ALWAYS died of blood infections.

    your body needs sleep.

    --

    There are some odd things afoot now, in the Villa Straylight.
    1. Re:looks similar to monofonil (sp?) by geekoid · · Score: 2

      of course, but how much?
      Everybody seems to be told 8 hours, but there have been several eperments with widely different sleep patterns that work well.
      Can our body lear to deal with 6 hours sleep? 4?
      I saw an interview with a guy who slept for 2 hours 3 times a day, evenly spaced. After the experiment he kept doing it, and had been doing so for years. He claimed it was great.
      there have been people through out history, from Marth Stewart, to Napleon, that only slept 4 hours a night, there entire lives.
      I could use the extra 4 hour, personally.

      --
      The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
  29. Provigil = Bad Experience by Anonymous Coward · · Score: 2, Interesting

    I was on provigil for a few weeks instead of Methelphenadate HCL as treatment for narcolepsy. The Privigil had wierd side effects, It effected my tiniking and kept seeing things out of the corner of my eye but when looked nothing was their. I looked on a news group about provigil and other people had similar side effects. Personally I would rather have a stomach ache or nose bleed as side effects instead of a messed up head/eyes.

    1. Re:Provigil = Bad Experience by Caractacus+Potts · · Score: 2


      After hearing about this stuff a couple days ago on FARK, I scoured the newsgroups for experiences. There was a very broad range of them, from very good to very bad. The range of doses involved was anywhere from 100mg to 1000mg a day. I also hang out in the ADD/ADHD groups and hear similar ranges of experiences for the variety of drugs used for that condition. It seems obvious to me that certain drugs, like Provigil, affect people differently. This is no surprise. It you have a bad reaction to it, stop using it. But, the guy standing next to you might respond to it favorably. I certainly hope that more options become available so that you're chances of leading a wakeful life improve. I'm not narcoleptic, but I know what it's like to be sleepy most of the time.

      Must take nap now...

  30. Try this instead... by loosenut · · Score: 2

    If you want to improve your powers of concentration, try Ginko Biloba. I've been taking it for years, 60 mg every morning. I've noticed that my alertness levels are waaay up. I swear by it.

    Others might agree.

    Note that ginko takes several weeks to build up in your system. Have fun!

  31. I was on this drug for 4 weeks last october... by jjn1056 · · Score: 2, Informative

    I was prescribed the drug by my doctor because a different medication I was on made me very sleepy in the morning. I was so tired it was affecting my ability to get up and go to work. When I was on Provigal I did notice some minor improvements; more alertness in the morning being the #1 effect. The effect was very minor, almost indetectable. I didn't feel wired or anything like what you get from coffee, and there was no 'crash' later in the day.

    I stopped taking it because I thought it was causing me to feel very sick to my stomach, but of course that might have just been because I live in downtown NYC and this was in October.

    Generally this is a drug taken by people with serious sleeping problems, like people that fall asleep while driving all the time, etc. It is also thought to have some affect on depression, although the mechanism by which it accomplishes that is unknown. It might just be that getting a good start on the day helps depressed people!

    Since this drug is not a traditional stimulant, such as caffeine, or cocaine, it can affect people in very different ways. It's more like Prozac, which seemed to help some people a lot, while others were not helped at all.

    --
    Peace, or Not?
  32. Wasn't there an X-Files episode... by ncc74656 · · Score: 2

    ...that dealt with experiments in sleep deprivation? While it's not likely that Provigil (make note of the spelling...if the editors had read the article, they would've gotten it right) is the result of some clandestine project to create soldiers who never sleep, it would appear to open the door to certain possibilities...

    --
    20 January 2017: the End of an Error.
  33. Here is an "interesting ethical question" by kindbud · · Score: 2

    What if your employer asks you to take it so you can be more productive? It's just for this big push to get the new product out by the deadline.

    What if at some future time when this drug is commonplace, you can't get a job in your field unless you agree to take the pill during the work week?

    What if the traditional work week disappears, replaced by 168 non-stop hours of wakeful, productive work?

    People are fond of responding to workplace privacy issues by pointing out that you're being paid for your time, and shouldn't be surfing or getting high or whatever, and so spyware and logging and drug tests are to be expected, and are an employer's right. How is this really any different? You don't have to work at a place that requires 168 hours of wakefulness, but if every employer in your town who has a position in your field is requiring this drug to be taken as a condition of employment, your kinda SOL.

    Is that enough ethical questions for ya?

    --
    Edith Keeler Must Die
  34. What ethical questions? by aminorex · · Score: 2

    I don't think it raises any interesting ethical
    questions at all. Could you suggest one?

    --
    -I like my women like I like my tea: green-
    1. Re:What ethical questions? by geekoid · · Score: 2

      making workers in sweat shops work another 40 hours a week?

      haha, but then, what doesn't raise at least some ethical question to someone?

      --
      The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
    2. Re:What ethical questions? by aminorex · · Score: 2

      's not an ethical question. 's a farfetched
      *hypothetical* question. Boss could do the same
      thing today without drugs, or with meth.

      --
      -I like my women like I like my tea: green-
  35. Re:Bad Idea by Tackhead · · Score: 2
    > The last thing the world needs is thousands of delusional psychopathics geeks!!!

    C'mon, the only hope any of us ever had of being millionaires was the dot-com boom - and what was that, other than what happens when you put thousands of delusional psychopathic geeks in the same room with thousands of delusional psychopathic venture capitalists and offer shares to millions of delusional psychopathic day traders?

    If that was delusional psychopathy, I want it back!

  36. new inventions makes life easier by geekoid · · Score: 2

    Today cavewoman groky invented a device that will make work easier. She does not know exactly how it works, but she calls it the 'wheel'.Hey anything that makes my life easier but it raises several interesting ethical questions.

    Everything raises ethical questions, whether or not there interesting is for people to decide for themselves.

    --
    The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
  37. Da Vinci by reflexreaction · · Score: 2, Insightful

    Like many other people I wanted get more productive hours out my 24 hour day so began studying napping in college and ending up doing my undergrad research project on napping. I ended up doing a fairly lame project but my original idea was to adopt this sleep pattern (awake 4 hours, sleep 15-30 minutes) and do tests on myself. While there have been anecodotes of this sleep schedule, there have been no documented cases and no scientific research. Incidentally, Leonardo da Vinci was supposed to have adopted this sleep schedule. It can certainly help explain the amazing work that he produced.

    The human body has many continuous overlapping cycles. The most prominent is the circadian rythymn, our daily clock. But there are longer cycles (women's monthly cycles) and a shorter one of approximatly 4 hours. Adopting this sleeping pattern would maximize restorative sleep (Stage 4 and REM) while minimizing the less productive sleep stages (Stages 1-3). When you adopt this sleep schedule, you immediately go into deep sleep and then dream within 5 or 10 minutes. The normal delay for dreaming is usually 3-5 hours.
    One last thing that I found in my research. While most people can deal with moderate sleep loss for an extended time 2-3 hours a night, there is a core sleep time of 4-5 hours that the average person must get otherwise they become non-functional.
    I would love to read up more on this drug and to see how the research has changed in the three years that I have left school.

    --

    We had to destroy the sig to save the sig.
  38. Not my Dew! by cetan · · Score: 2

    They'll take away my Dew when they pry it from my cold, dead, still-shaking hands.

    Besides, Mountain Dew reduces your sperm count, so it keeps those bastard children away!

    --
    In Soviet Russia...michael would be rotting in Siberia!
  39. Normal Sleep by phriedom · · Score: 2, Insightful
    Yes they do mention that. Its at the end of the section that explains how it is different from caffiene and other stimulants.
    Caffeine and older prescription stimulants buzz the entire central nervous system, causing jitteriness, insomnia and other unwanted effects. When people who use coffee or amphetamines to stay awake finally doze off, they often remain in bed for much longer than usual, their bodies paralyzed by the need for "rebound sleep." Provigil, meanwhile, seems to target only the part of the brain that keeps us awake. When its effects wear off, the user resumes a normal sleep pattern.
    --
    Don't moderate flamebait as Troll. Know the difference or you will be Meta-moderated.
  40. Stripper's Trilemma by cjsnell · · Score: 2


    I think you were alluding to the Stripper's Trilemma:

    Dance harder -> make more tips -> buy more coke -> dance harder -> etc

    :)

  41. I wonder what you'd get... by Polo · · Score: 2

    So what if you made a combo pill of provigil and viagra? ;)

  42. According to the Pocket PDR by ConceptJunkie · · Score: 2

    It is a stimulant, although it was described to me by a doctor as not being one.

    Nevertheless, it is listed a class IV controlled substance, not as bad a Ritalin, but it is supposedly addictive.

    However, it does work as advertised.

    --
    You are in a maze of twisty little passages, all alike.
    1. Re:According to the Pocket PDR by ConceptJunkie · · Score: 2

      I never implied that class IV == addictive and since the info in the PDR tends to be pretty minimal, I don't take it as gospel, I was just relaying what I read.

      Nevertheless, thanks for the info.

      Any chance this stuff will go OTC any time soon?

      --
      You are in a maze of twisty little passages, all alike.
  43. Re:If it works, gimme! by Tattva · · Score: 2
    Think EverQuest 24 hours for 3 days.

    And they call it EverCrack now.

    It's too horrible to contemplate: sleep is the only thing moderating the life cycles of some of hard-core addicts and preventing them from sinking as far as drug addicts can (most addictive drugs are stimulants and keep you up.) Without sleep regulating their addiction the whole lot of them will descend into dementia, not that they aren't far from that now.

    --
    personal attacks hurt, especially when deserved
  44. Am I the only person here... by djocyko · · Score: 2

    that wished he had more time to just sleep?

    or is that one of those things you're not supposed to thnk about...

    1. Re:Am I the only person here... by realdpk · · Score: 2

      I hear ya - plus, I wish I was able to have better sleep. Unfortunately pager duty means I have to get woken up at all hours several times a night in some cases.

      And no, I'm not find another job - there aren't many out there in my field (and region), and other careers wouldn't pay as well (entry level).

  45. Oh, sweet ignorance by dswensen · · Score: 2

    Wha... the... Starbuck's owns Tazo...?

    *stumbles off weeping quietly*

  46. If I take a handful of these... by Junior+J.+Junior+III · · Score: 2

    do I need to buy extra fans to attach to my head, to counter the extra heat that'll be generated from overclocking my brain?

    --
    You see? You see? Your stupid minds! Stupid! Stupid!
  47. Two words: BEE POLLEN by phreakmonkey · · Score: 2, Interesting
    Keeps you wired for hours.. that is, unless you're allergic to bees, in which case it can probably kill you.

    You can find it at most herbal stores, and some drug stores.

  48. Be True to Your Circadian Rhythms by benthesinister · · Score: 2, Interesting

    It is important to remember that Leonardo Da Vinci was a truly strange guy. Interestingly enough, many of the most creative people of all time had unusual sleep habits. Einstein slept up to 14 hours a day. Edison would stay awake for over two days at a time, only to crash and sleep so long that he had to find a newspaper to learn what day it was. Euler was nocturnal. Seeing this, it is probably also important that we strive to live in accordance with out own sleep patterns, rather than try to defy your body with drugs. I personally have Type II Circadian Rhythm sleep disorder, which means basically that I'm nocturnal. As much as possible, I build my schedule to be night-oriented. Not so easy while school is around, but when school isn't a factor, you will see me awake until dawn and asleep until near dusk. When I am obeying what my body is telling me to do, I am happier, healthier, and smarter. Pass on the Provigil and instead take a chance to try out sleeping when your body tells you to.

    1. Re:Be True to Your Circadian Rhythms by arkanes · · Score: 2

      Interesting - absent work and other outside influences, I also gravitate toward being nocturnal. And it's _HARD_ for me to get up in the morning after 8 hours, whereas if I go to sleep around 4 am and sleep till 10, I'm refreshed and alert. I had no idea this was actually studied and classified - do you have any links where I can find out more about this sort of thing?

  49. Sleep and Dreams... by BlackGriffen · · Score: 4, Insightful

    I would advise against using this if you want your memory to function. It's still probably just a theory, but I still remember hearing the most probable explanation for the brain's need to sleep that I've ever heard. Basically, the theory goes that when you enter deep sleep (i.e. non-REM sleep) your brain is literally wiring new connections: shifting memories to long term storage, connections are reinforced with more connections, etc. Your brain then goes in to REM sleep to test those connections, which is why REM sleep seems pretty random, but is often related to what's going on in your life.

    Some evidence for this: there is a specific type of autism (I can't remember the name) that baffled researchers until they started monitoring the EEG's at night. The researchers found out that the people with this type of autism were literally going in to seizures at night, at least they were experiencing the "electrical storm" in their brains that characterize a seizure. The researchers put the patients on anti-epilepsy medication, and it cleared up the symptoms right away. As the theory goes, the brain was using all of it's connections every night, preventing unused/unneeded connections from atrophying. So the patient was literally unable to forget anything, but also didn't have any more room for more connections.

    The moral of the story (considering that only a fool wouldn't realize that these pills won't be more abused than Viagra)? Don't use/abuse these pills if you want to be able to remember/learn anything long-term.

    BlackGriffen

  50. Fantastic! by brooks_talley · · Score: 3, Funny

    It's also still in testing so it'll probably make you grow horns or something

    So I can get more work done in a day, and grow horns? I want in on the clinical trial!

    Cheers
    -b

    Girlfriend sez: "In your case, it would just make the ones you already have visible."

    1. Re:Fantastic! by namespan · · Score: 2

      it'll probably make you grow horns or something

      Or you could become a Mormon, like me.... : )

      --
      Libertarianism is rich wolves and poor sheep playing gambler's ruin for dinner.
  51. Holy Manna!! by Noexit · · Score: 2, Interesting

    As an individual who suffers from both chronic depression and insomnia, something like this would be gold to me. Rather than taking drugs that try to force my body and brain to sleep, this would allow me to take better advantage of the hours that I spend awake. Instead of working at 4 in the morning because I can't sleep and piling up errors, I could work at 4 in the morning because I can't sleep and keep everything accurate and precise.

    --

    Never argue with a man carrying a water buffalo

  52. Remember ASPIRIN! No one knew how it worked!!! by Caractacus+Potts · · Score: 2


    Well, you probably won't remember, but your great-grandparents might have gone through this. When aspirin was first commercially used in the 1870's, no one knew how it worked. It sure was nice that it did work thought, even if an occasional upset stomach occured. It wasn't until the 1970's that it's relation to prostaglandin was discovered. Read this link for more info.

  53. CFIDS: Yeah, I know about it. by MsGeek · · Score: 2
    I do not know if this is being tested as a treatment for Chronic Fatigue Syndrome or not, but people who suffer from that can sleep up to 20 hours and still feel wiped out.

    I can relate. I had CFIDS (Chronic Fatigue Immune Dysfunction Syndrome) and still suffer some aftereffects from it.

    During the acute phase of the illness, I definitely experienced what you are talking about. I got lucky...I have not had an acute period since 1994. However, I still have residual effects which include a permanently impaired stamina, and problems with transferring data from short term to long term memory. I also have the annoying habit of occasionally losing consciousness for a few seconds at a time. I call it a "brown out." Some people call it "brain fog."

    Anyway, what I'm really saying is...lemme at this stuff! I can definitely use it. If it won't affect blood pressure, I want it.

    --
    Knowledge is power. Knowledge shared is power multiplied.
  54. Sleep deprivation is -bad- by Chris+Burke · · Score: 2

    As I know very well from 7-days-on-5-hours-sleep binges during college, staying awake for long periods, even if you feel alert, eventually catches up to you. And as someone suffering from a sleep disorder currently, I know that going long periods without much sleep can be very bad. What makes me worry about this drug is that it may work too well. After a week of sleep deprivation, no amount of coffee will keep you from feeling sleepy. You will fall asleep after a point. But if you can pop this pill and not feel sleepy, you may stay up far past what your body can take.

    --

    The enemies of Democracy are
  55. Re:I've NOT used it, BUT by RobPiano · · Score: 2, Interesting

    My best friend uses it now.

    She's narcoleptic and after the second time she drove her car into a ditch she finally got tested and they put her on Provigil.

    This drug has literally been a life saver! (for everyone else on the road).

    It is really a nice drug with a low occurance of side effects. Its not like she is suddenly restless, but rather she doesn't fall asleep so unexpectedly.

    The only negative things she has to say about it is that because it is metabolized by the liver, you really shouldn't drink alcohol while on it. This is kinda a bummer at parties.

    Word,
    Rob

  56. How long you sleep. by mindstrm · · Score: 2

    How long you will sleep after being awake for 36 hours is not a constant, but what is a constant is that, over time, you average 8 hours a day, period, without variation. IF you miss some, you will make it up, over the next few days, or even weeks.

    Track your sleep for a year, and just see what happens. Don't forget to count nodding off at the desk and sleeping on the bus.

  57. Re:It won't replace coffee. (offtopic) by slickwillie · · Score: 2

    Intellectual Property: Something the average MCSE doesn't have between his ears.

    I saw a book in Borders the other days with the title Windows XP for Dummies, and I thought "It sure is".

  58. Yeah. . . by Fantastic+Lad · · Score: 2
    AND brain damage and/or 'pill' addiction.

    Coffee has been around for ever. We know the positive/negative effects. It is trust worthy.

    In the current corporate/government lobbyist environment I wouldn't touch ANYTHING even vaguely pill shaped which is designed to improve my 'worker drone efficiency'.

    Will it also turn me into a slobbering 'yes sir' zombie?

    Call me paranoid, but they can take that pill and shove it!


    -Fantastic Lad

    1. Re:Yeah. . . by kubrick · · Score: 2

      Call me paranoid, but they can take that pill and shove it!

      If suppositories are the only way of administering it to you, then I'm sure they'll be telling you to bend over any time now. :)

      --
      deus does not exist but if he does
  59. Not the first chemical of this nature by machinegestalt · · Score: 2, Informative

    There is another which has similar effects, called 4-methylaminorex (dl-cis-2-amino-4-methyl-5-phenyl-2-oxazoline) which effects most specifically the the norepinephrine and acetylcholine receptors in the brain, with comparitively minimal/nonexistant effect at the dopamine receptors unlike most standard stimulants.

    Unfortunately this chemical has a rather long active duration when taken by oral administration (which, besides it's potential for abuse, is probably the main reason this chemical has not seen commercial use), however it VERY effective at reducing the effects of sleep deprivation without the anxiety and psychotic effects usually attributed to methamphetamines and other stimulants which are highly active on the dopamine system.

    As for the previously mentioned Uberman sleep schedule, I can see it being effective at producing mental altertness with a minimum of sleep, however I would suspect that it would have an effect on the recuperative capabilities of your body in addition to reducing the immune system. As a weightlifter I've found that additional sleep beyond the eight hours I usually require is very helpful in speeding recovery.

    Machine Gestalt

  60. Re:Whatever happened to good old SPEED? by JohnnyBolla · · Score: 2, Funny

    Hell, that's a plus! Who wants a paranoid psycho to be able to bite them?

    --
    Carpe Deez
  61. Unmentioned Side Effects! by darkstar2a · · Score: 3, Informative
    Other than headaches (50%) and Nausea (13%), there are some issues here.

    Provigal affects Birth Control!

    Patients should be advised to notify their physician if they become pregnant or intend to become pregnant during therapy. Patients should be cautioned regarding the potential increased risk of pregnancy when using steroidal contraceptives (including depot or implantable contraceptives) with PROVIGIL tablets and for one month after discontinuation of therapy
    I found a few references to possible birth defects as well, however not seriously sightable statements. Even the official website states that dosage during pregnancy should seriously consider the benefits to outweigh the risks.

    The strangest issue is that for a drug that has been around since the 70's there is very little data about interaction with other drugs and they just recommend you don't use alot of different types. Brings up something I remember hearing about a company in the past that found negative results and decided that they just "hadn't performed those tests". Who knows.

    Buyer Beware.

    I'm male though, so where do I order my emergency supply! :)

    Garth/Darkstar

  62. Lembas by wdr1 · · Score: 3, Funny

    ...Provigil, whose name is shorthand for "promotes vigilance."

    *sigh*

    Lembas would have been such a better name.

    -Bill

    --
    SlashSig Karma: Excellent (mostly affected by moderatio
  63. Oh yeah ... this sounds healthy... by telstar · · Score: 2

    Every night before leaving for work, Jaegers takes two small tablets--she calls them "magic pills."

  64. Exercise is making a huge difference for me by mikosullivan · · Score: 5, Insightful

    I've had a problem with getting sleep during the day for years. It has nothing to with how interested in my projects I am or how much sleep I get: I would always get sleepy right at 10 am and about 2pm. Lately I've taken to walking to work each morning (about five miles) and it's made a huge difference. It took me a week to realize that most of my sleepiness problems had disappeared. Now, a month later, there's no mistaking the difference: if I walk to work I feel alert. If I don't, I get sleepy. I usually hate exercise but I enjoy the walk.

    --
    Miko O'Sullivan
  65. Re:Sleepiness by EllF · · Score: 2

    Have you tried exercising briskly every day? A regimine that hurts - I personally do 3 sets of 50 crunches, 25 diamond pushups, 25 regular pushups, 25 curls (at 25lbs.), and 25 hammer curls - but doesn't leave you unable to move could do wonders for you energy level.

    Another thing to look at is diet; incorporating more greens and less fat into your food intake (especially at lunch) can have serious and positive effects on how alert you feel during the day.

    Finally, are you sleeping a consistent 8 hours every night? Variances in how much sleep you get is apt to make you feel fuzzy; more than 8 hours invited sluggishness. A solid schedule, combined with good exercise and a healthy diet, could eliminate that "constantly sleepy" feeling.

    --
    We who were living are now dying
    With a little patience
  66. I have too. by onjay · · Score: 3, Informative
    As someone who literally can fall asleep in two minutes and someone who has to pull 24-28 hour shifts requiring intense attention on a monthly basis (and still make it home), I did reach beyond the caffeine to the antinarcoleptic Provigil. I am not impressed, and will stick to coffee. YMMV, and FWIW I do keep one tab on me in case I absolutely absolutely had to stay awake into the 40-50 hour range for a road trip.

    My test drive opinions, negatives first:

    - headaches - Very distracting and not fixed with OTC remedies. I consider this a killer side effect. I saw this at both 100mg and 200mg.

    - da jitters - well, if you are going all Cornholio, it is going to cut into your productivity. I went from juggling 5 different things at once to dropping three and fucking up one of the remaining two. Maybe you can train yourself to keep it all together.

    - elevated blood pressure - This may have something to do with the headaches, but that feeling of impending aneurysm does not rock.

    - dehydration - I fly through the water, and all of my piss smells really rank and chemical-like. There is a productivity hit to this I suppose, and it seems like more than that imposed by chugging coffee.

    - rebound - the crash can be hard, and the duration of sleep is not really predictable. I tended to be irritable the day after, as well.

    positive: you are slightly more alert. 100mg and I can still sleep no problem. in my chair. . .not good. 200mg and you are are awake, but more side effect manifestation.

    DO NOT take 4 per shift like the guy up there. You are going to get prescription info from Slashdot?

    Don't be a dumbass: check out the info on ANY drug before you take it. Know the maximum dose. Know the interactions. Know the side effects. Know if it is excreted by the liver or kidney if you have problems with one of them. If you are going to take the doctor out of the loop, who is going to look out for your sorry ass?

  67. Re:Hallusinations (sp?) by Hard_Code · · Score: 2

    "carpet would start to crawl - literally moving backwards and forwards"

    Same here...happens to walls and ceilings also etc. You can sometimes fool your mind into doing it when you are not sleepy...or perhaps you've had to have this experience first, dunno.

    When I get really tired I start thinking I see spiders scurry and flies whiz past, when in fact its just a dot or shadow or something.

    --

    It's 10 PM. Do you know if you're un-American?
  68. Re:keep clinging to that by Graspee_Leemoor · · Score: 3, Funny

    " if a drug was discoverd tomorrow that got you high for 1 hour, had no side effects and made you glow neon orange so every cop could know you were on it, it would still be illegal in the u.s. if it were fun."

    Fuck the drug effect, I wanna glow neon orange! Bzzzzzz! Think how cool I would look, and how the chix (tm) would be impressed with my glowing goodness.

    glowing graspee

  69. Re:Whatever happened to good old SPEED? by Graspee_Leemoor · · Score: 3, Interesting

    Speed is physically addictive. It fucks your heart up. Many people end up injecting it. You never know what you're getting. You're paying people (dealers) you'd rather not have to be in the same universe with.

    I have made it through many tough projects without using illegal drugs.

    I know loads of people are now going to slap me down, disagree and generally piss all over me, but I don't want anyone to risk using speed after reading your post.

    graspee

  70. What about the LGMs? by supabeast! · · Score: 3, Insightful

    A lot of people seem to think this is a pretty cool idea for those long binges of coding/system administration/photoshopping/etc.. Sure it keeps you awake, but what about one of the really nasty downsides to sleep deprivation that I am sure most /. readers have experienced: hallucinations. I can honestly say that I have on numerous occasions been up all night playing EverQuest/Final Fantasy and then gone straight to work with little if any sleep (And help from my friends at Starbucks.); resulting in aural and visual hallucinations. About that time I pass out, but I have a friend who can go for 36+ hours without crashing, and experiences what he calls "LGMs," short for little green men. What happens when the geeks of the world can stay up for days at a time- do we go into hallucinatory overdrive? Or does Provigil deal with the LGMs? Anybody know?

    1. Re:What about the LGMs? by Zathrus · · Score: 2

      Provigil keeps you awake. Period. They've done tests and there are NO negative side effects that anyone's found out to at least 72 hours.

      I take it as prescribed, for narcolepsy. I can't personally attest to the above, since 200 mg pills don't even keep me awake for 12 hours, much less 72.

  71. Ethics? by DickBreath · · Score: 2

    Just ask Dr. Franklin from B5 about overuse of stims.

    --

    I'll see your senator, and I'll raise you two judges.
  72. Well I'm glad.... by crumbz · · Score: 2

    ...that this discussion has deteriorated into illicit drug use.

    Then again, that is what /. is for!

  73. Towards a brave new world... by Nagash · · Score: 2

    So when do I get my damn soma?

    Woz

  74. Re:Hallusinations (sp?) by TheOnlyCoolTim · · Score: 2

    Often when I find myself napping outside the bed I have dream images that are the exact same image I would be seeing if my eyes were open. So say my head is in my arms on a desk, I will see my arms and the desk in my dream...

    Sometimes it happens when I'm still mostly awake and I know my eyes are closed but I'm still seeing. It is really weird...

    Tim

    --
    Omnia vestra castrorum habetur nobis.
  75. Some background by Da_Monk · · Score: 2

    here is some more info:

    scientists are still not sure how it interacts with known neuro-chemicals.

    it was developed for the french army.

    the hype about it is way overrated, you will still feel fatigue.

    It did not do well in placebo tests, not well at all.

  76. Correlation != causation by wowbagger · · Score: 2

    Your interpretation of the study you cite is flawed.

    All the study said was "we took a bunch of people, sorted them by the time the slept, and noticed that the people who slept less live longer".

    I could also say that heart disease causes smoking, since I could take a bunch of people, sort them by the health of their hearts, and notice that the sicker folk tend to smoke.

    What if, in the set of people who slept longer, there was a disproportionate number of sick individuals (sleep apnea, chronic allergies, whatever). They might be sleeping more because they are sick, and have shorter lifespans because they are sick.

    The way you would prove the hypothesis that "less sleep is good for you" would be to take a set of people selected to be of the same level of general health, measure their natural sleep patterns, then take half that group and reduce their sleep time by 20%. Then wait and measure the effect on their lifespans. That way, you factor out the effects of the health of the individuals.

  77. Used to read 'til 4AM every day... by crovira · · Score: 2

    and get up and go to work at 07:30. I never knew there was a name for it.

    But it catches up with you.

    My idea of geting up late on Saturday morning was 04:00 Sunday morning.

    That really fucks up you biorythms.

    --
    MSBPodcast.com The opinions expressed here are my own. If you don't like 'em... Think up your own stuff.
  78. First responders... by Shoten · · Score: 2

    I'm on an incident response team, and I would love to be able to have these on hand. There have been times when I've already been sleep-deprived, only to have to jump on a plane and do 100 hours of high-pressure work over the next 5 days. I typically go through two entire tins of Warp mints during this...I'd really like something that doesn't feel quite so rough!

    --

    For your security, this post has been encrypted with ROT-13, twice.
  79. Several points. by mindstrm · · Score: 2

    1) Caffeine is addictive. People don't just drink caffeine to stay awake, caffeine junkies drink it because if they don't, they hurt.

    2) This is probably a great alternative to cns stimulants. IT probably IS much, much easier on your body and hence safer.

    3) #2 does not mean that you still don't need sleep, it just means you don't have to deal with the jittery side effects of most CNS stimulants when you need to avert nature and stay awake. You STILL need to (and invariably will) catch up on lost sleep.

  80. Re:Caffeine by mindstrm · · Score: 2

    Uhh.. mountain dew and coffee taste good the same way cocaine smells good.

    It's the positive response of your body to the caffeine that makes your mind decide "This flavor is a good flavor."

  81. Buffer Overrun... by Skip666Kent · · Score: 2

    My pet (rat?) theory is that the brain, while awake, is in 'recieve' mode, regardless of how much or little we are actively 'thinking' at any given time. REM level sleep is when the input effectively stops (except for a few low-level threads to detect breaks in the sound/environmental impression patterns that have been proven over time to imply a 'safe/uneventful' night's sleep - until your child cries or a thief breaks a window in the basement) and our cpu can sift through the data, keeping some bits, tossing others, and making all sorts of connections and projections with our existing 'database' of knowledge, impressions and experiences. When deprived of REM level sleep, our brains never get to relax and assimilate what they have recieved, but try to anyways, leading to the hallucinations and such.

    The deprivation is as frustrating and alarming to our system (over a longer term) as being deprived of air or water. The body/mind goes into Panic mode eventually in the effort to extricate itself from whatever situation is causing the deprivation. All these factors stack up and grow worse over time with extended deprivation.

    Sleep and Dreams, essentially, are when our brains get to breathe.

    --
    **>>BELCH