Gene Therapy Creates Strong Super-Rats
srstoneb writes "The AP is reporting about a
gene therapy study in which muscle tissue in rats is modified to grow at an accelerated rate. The researchers are mainly interested in combating muscular dystrophy, but obviously there are other potential applications, both good and bad, for a treatment which makes you stronger. Athletic ethics are addressed in the article (it's in the sports section, after all), and rec.arts.comics.marvel.universe regular Tom Galloway -- who posted the link there, where I saw it -- made a comparison to the 'super-soldier serum' that created Captain America. Based on the article, a vaguely Wolverine-like healing factor is another benefit as the therapy allows faster recovery from injury. We already had a non-powered superhero
reported last year. Who knows what the future may hold? ^_^" (And that's not the only natural-born superhero.)
Rats with "vaguely Wolverine-like healing factor".
Wonderful.
I can see the pest control guys kitting up with miniguns and RPGs.
In the free world the media isn't government run; the government is media run.
I for one welcome our new mutant rat overlords.
G4 Hackintosh
Progis Riport 1.
Algernon kickd me in th nuts! It is sawr.
Superrat "Mitee Mus" runs for governor of the Democratic Republic of California, winning 63% of the votes. Standing 7'3" tall, weighing 120kg and gifted with an IQ of 192, Mitee Mus told reporters "Now I can get to the real business of building nice warm nests for every Californian". He is married to the cousin of a Kennedy.
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This is the only way we'll be able to compete in hand to hand combat with the robots that we'll assuredly create and be forced to fight against in the near future.
With the rise-and-rise of agribusiness and the permanent pressure they place on our governments, how long before such genetic modifications are made to cows, pigs, etc.?
Bus error in your favour. Collect 200kB
You mean the usenet is still used for things besides spam, porn, and warez??? I can't believe it.
I thought that the concern with steroids was that they posed long-term health risks... not that they made people stronger. The concept of limiting strength to those with naturally good genes is quite elitist.
That's like saying that someone with bad eyesight shouldn't get glasses. If this therapy is as side-effect free as claimed, then why shouldn't people be allowed to use it?
After all, implants and other non-essential plastic surgery is legal...
Reference is to "Flowers for Algernon."
It sounds great in theory, but there are all kinds of potential problems with rapidly and artificially increasing strength that way.
If you increase strength very rapidly without allowing for the corresponding tendons and bone to adapt to the greater muscle mass, you can cause tendon ruptures and stress fractures (already well-known phenomenon in athletes). The body can adapt to all kinds of derangements if you give it enough time, but too much too fast? Bad news. I've seen people come in to the hospital with a hemoglobin level of 5, still walking (slowly) and talking. Now, that's theoretically too low to survive on, but if it happens over a long enough period of time, your body can adapt. If you take a normal person and immediatly bleed them down to a hemoglobin of 5, they'll die.
Plus, if you are turning over too much muscle tissue too fast and don't stay adequately hydrated, you can clog your kidneys and end up in renal failure. This happens periodically when some untrained amateur athelete tries an Ironman without adequate conditioning.
The human body is an amazing machine, but you have to be careful monkeying around with it... athletes may be after performance, but anyone who volunteers to be a guinea pig for this stuff needs his head examined.
Even if a man chops off your hand with a sword, you still have two nice, sharp bones to stick in his eyes.
I wonder if this would also help stop or reduce the breakdown of muscle tissue, when used to combat the effects of genetic conditions like Marfans Syndrome.
Another application might be to solve certain heart related issues. There isn't exactly a huge replacement supply right now.
8==8 Bones 8==8
Great, we have the rat... now we just need some turtles.
Why do you think an american tenderloin beef is larger than a european one? Correct - the US beef is gene modificated. That's why there's a ban on importing beef from the US to Europe. Now, this has been going on for more than a decade. Altering muscles genetically is not news! But using the enlarged muscles for something other than to make larger beefs is. Of course, this has been explored in countless action movies already like Soldier and Drive
I actually have muscular dystrophy, and although it doesn't affect me, it affects my mum, and potentially my children - I'm damn glad that someone has taken the time to research this oft (relatively) overlooked genetic disease.
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I wonder how 'vaguely Wolverine" these healing abilities are.
It's be interesting to see precisely what applications these advancements are seeing in military use. Sure, it's unlikely that any serious or controversal issue gets used right away by mainstream military, but surely there are special military groups that get "advanced tech" quite, in, er, advance of the main military force.
I heard/read somewhere once that the US military's "high end" technology is 12 years more advanced than anything that is actually available for the mainstream military force, and only used by Special Ops.
Consider how un-advanced things were during the first desert storm compared to how they are now - and jump ahead another years, and think of an equal amount of differential, if not an exponential differential. Wow.
~/ssh slashdot.org ssh: connect to host slashdot.org port 22: too many beers
Look at TNG, the advance imune system also kills.
Fight Spammers!
For someone with Marfan's syndrome.
Marfan's syndrome is a genetic defect in the gene that codes for Fibrillin, a major component of microfibrils in the body's connective tissues. Much of the pathologic consequences are noted in the eye and the aorta... the former location gets dislocations of the lens, and the latter location develops large (fatal if undiagnosed) aortic aneurysms. Marfanoid patients also tend to be tall, and have a lot of laxity in their joints, primarily because of their weakened connective tissues.
If you have weaker connective tissue than normal, it would probably be counterproductive to have greatly increased muscle mass.
I'm not picking on you, just pointing out that it might not be exactly what a Marfan's patient really needs... It might be useful in some kinds of muscular dystrophies, but the most common kinds have defective myofibrils... creating more non-functional muscle wouldn't appear to help them very much.
Even if a man chops off your hand with a sword, you still have two nice, sharp bones to stick in his eyes.
" ... Eugenics war ... "
That is the least of our worries!!! PRAY that your grandchildren will NOT have a neat little inscription behind their right ear that reads.
"DNA Encoded by Microsoft (c)."
Only to idiots, are orders laws.
-- Henning von Tresckow
I will assmeble the ultimate real-life superhero team to Save the Universe! It will be called the Ultimate Super Hero International Team! The roster is carefully chosen to represent the most gifted and talented real-life adventurers from across the globe!
On it will be the daring leader and Weapons Expert, Angle Grinder Man! (Linked to above.) Also...
Aerospace Expert: Lawn Chair Larry!
Science and Technology Expert: Troy Hurtubise, inventor of the famous Bear Proof Suit! (Tested by real bikers! And bears! It's bear and biker proof!)
Matter Eating Expert: Sonya Thomas, the Black Widow!
Sneaking Across the Country Naked Expert: Steven Gough!
With these mighty heroes, the Ultimate Super Hero International Team, the Universe shall be Saved!
SoupIsGood Food
The stupid thing is that if they were just in it for the prize money, they could have taken up golf and got paid far more for the onerous duty of wearing a particular brand of patterned sweater.
When I am king, you will be first against the wall.
Just wondering if this would be useful for building up muscle mass to combat long periods in low-gravity - such as a manned trip to Mars?
----------------------------------- My Other Sig Is Hilarious -----------------------------------
There exist entire categories of diseases based entirely on immune system problems.
Rheumatoid arthritis, mixed connective tissue disease, Lupus, etc... all are autoimmune, and are a result of the body's immune system attacking itself. These diseases can be devilishly difficult to diagnose and treat... there's a reason why Rheumatology is its own medical specialty. Some of the drugs the rheumatologists use are potentially nasty, and include transplant drugs, and chemotheraputic agents... not stuff for the faint of heart.
By the same token, when you start monkeying around with DNA, you need to be careful what genes you activate or deactivate... Cancer is fundamentally a genetic disease, and a real possibility if you get an unregulated growth gene (or you inadvertantly turn off a suppressor gene). Cancers are funny things; they can even respond to simple hormones... precisely why women with a breast cancer history aren't advised to receive hormone replacement therapy.
Gene therapy has had some successes, but it's really in its infancy... I'd be awfully leery about using it just to bulk up at the gym. On the other hand, if you have a lethal genetic defect, and you're going to die without it, have at it. Forget Hans and Franz... you can find quite a few patients with potentially lethal genetic diseases (Cystic Fibrosis, etc) who'd be much better candidates for gene therapy than some weight-lifter.
It bears repeating... using it for simple body-building is absolutely foolhardy... instead of growing big pectoral muscles, you might inadvertently be growing yourself a big fat tumor... that'll look great at the beach.
Even if a man chops off your hand with a sword, you still have two nice, sharp bones to stick in his eyes.
Darl McBride is a Russian boxer?
I have something in common with Stephen Hawking...
at least they'll have blue eyes then.. or at least occasionally..
No one can understand the truth until he drinks of coffee's frothy goodness.
--Sheikh Abd-Al-Kadir, 1587
That's funny, because I guarantee you, no matter how hard I tried I could not become professionally competitive in likely any athletic event. I don't have the natural genes for it. So it's just luck that the top people got the superior genes (for this task), but it's cheating if I engineer my children so they have them?
The real complaint (and the one I'd support for now) is that any gene therapy that will come around soon will be dangerous. Others have mentioned potential downsides of massively increased muscle production, and most potentially enhancing gene therapies would be best expressed through geneline engineering, where a developing embryo is genetically modified. The ethics of that aren't pretty, and its first uses are going to be therapeutic in nature. When it's safe to actually enhance though, there's going to have to be a new look at the old rulebooks banning genetically altered atheletes.
is a real phenomenon... I've seen people go truly bonkers from high-dose steroids.
It seems to be dose-dependent, and your chance of developing it is independent of whether you've had it in the past (ie. just because you went nuts one time, doesn't mean you'll do it again). Your odds also seem to vary depending on why you're receiving the steroids, suggesting that the initial disease process plays a role.
It's also more common in women than men (no joke intended or implied).
Some people don't like steroids, but I do (having been prescribed them in the past)... they give you lots of energy, all your little aches and pains go away, and you feel good. (there is a certain amount of euphoria with steroids). But there's a downside... a big downside. Check any medical text (or the PDR) for the long-term side effects of steroid use. Go ahead, I'll wait.
Ok, you looking at it? Yeah... that's the list I'm talking about... the one that goes on for several pages (and includes "roid rage")... you don't want to get on the long-term steroid train unless you absolutely have NO alternatives. That said, properly applied in the proper dose and for the proper duration, they're great, helpful, and lifesaving drugs... one of the most useful drug classes in modern medicine's arsenal.
Even if a man chops off your hand with a sword, you still have two nice, sharp bones to stick in his eyes.
Dennis Miller: In response to what its sponsors claim is an idea whose time has come, the first All-Drug Olympics opened today in Bogota, Columbia. Athletes are allowed to take any substance whatsoever before, after, and even during the competition. So far, 115 world records have been shattered! We go now to correspondent Kevin Nealon, live in Bogota for the Weightlifting Finals. Kevin?
Kevin Nealon: Dennis, getting ready to lift now is Sergei Akmudov of the Soviet Union. His trainer has told me that he's taken antibolic steroids, Novacaine, Nyquil, Darvon, and some sort of fish paralyzer. Also, I believe he's had a few cocktails within the last hour or so. All of this is, of course, perfectly legal at the All-Drug Olympics, in fact it's encouraged. Akmudov is getting set now, he's going for a cleaning jerk of over 1500 pounds, which would triple the existing world record. That's an awful lot of weight, Dennis, and here he goes.
[ Kevin steps aside to reveal the steroid-bulked athlete bent over to lift the 1500 lbs. weight. Sergei tightens his grip on the barbells and pulls up, but instead of lifting the weights, his arms are pulled off and blood squirts ferociously out of his pulpy stubs. ]
Kevin Nealon: Oh! He pulled his arms off! He's pulled his arms off, that's gotta be disappointing to the big Russian! [ Sergei's trainer wraps a towel around him ] You know, you hate to see something like this happen, Dennis! He probably doesn't have that much pain right now, but I think tomorrow he's really gonna feel that, Dennis! Back to you!
Dennis Miller: Thank you, Kevin. Very nice form on the Russian. Canada, of course, is leading that competition.
credit
"Sic Semper Tyrannosaurus Rex."
'What do we do tonight, Brain?'
'That's Magneto, damn you! And we do the same thing we do ever night, Pinky.. try to take over the world with our rodent superpowers! And how many times do I have to tell you? Stop licking off that blue body paint!'
Some of us already vote with our wallets, and i'd second the notion that it's how to get the idea out there that we might want to know what's in our food. I hate to bring up the same old song again, but the truth is that there are a lot of reasons for GMO food to be labelled, and some of it has to do with current, known allergies, intolerances, and illnesses. Obviously, this won't matter if a GM rat makes it into the food market- anyone who's eating rat probably isn't watching their diet for such things too closely. But when it comes to cows? It's hard enough to find cows that aren't being fed other cows (mad cow disease, anyone?) Do we know what a prion disease would do in a supercow? would they be more immune, or would they just survive longer as incubators, becoming more infectious once they got turned into feed? (I don't know if they're 100% sure that that's how it spreads, but i think that's what they've decided to go with here in the US.)
What if they just show fewer symptoms?
Granted, the non-organic but anti-growth-hormone folks might like this path (except for me, but i'm a treehugging crazy white chick who has immune and food allergy problems; i have to be careful what i buy in the first place) but i'd like folks to have a lot more time to think about it before it hits the market.
"I'd say 'Have a good time,' but arson is still illegal.
How about this guy? Freaky-low lactic acid production, high lactic-acid clearing, huge heart, VO2 Max (oxygen uptake to blood) more than twice the average person... And he beat cancer when he had about a 20% chance of living through it. Then he went and won the toughest race in the world. Five times. In a row.
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